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TR 399 Rat Pathology Tables

NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97
Route: GAVAGE                                                                                                     Time: 08:50:31




       Facility:  TSI Mason Research

       Chemical CAS #:  1271-19-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 4| 7| 4| 7| 7| 7| 7| 7| 5| 3| 7| 7| 6| 5| 4|             
                             DAY ON TEST   | 4| 4| 4| 4| 9| 5| 4| 0| 4| 0| 6| 5| 6| 5| 0| 5| 5| 4| 7| 8| 5| 5| 2| 7| 1|             
                                           | 3| 3| 9| 3| 4| 0| 4| 0| 9| 4| 4| 0| 3| 0| 2| 0| 0| 4| 4| 4| 0| 0| 2| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    79 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +     +  +  M  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Leukemia Mononuclear                 |          X        X                          X  X              X  X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Acinus, Adenoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Pulp, Fibroma                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Leukemia Mononuclear                 |                                                                X         |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  M  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  M  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  M  +  +  +  +  M  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                X  X      |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              | X                       X                 X                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  M  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Adenoma                              |                                        X                                 |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M     +     +  +  +  M  +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 4| 7| 4| 7| 7| 7| 7| 7| 5| 3| 7| 7| 6| 5| 4|             
                             DAY ON TEST   | 4| 4| 4| 4| 9| 5| 4| 0| 4| 0| 6| 5| 6| 5| 0| 5| 5| 4| 7| 8| 5| 5| 2| 7| 1|             
                                           | 3| 3| 9| 3| 4| 0| 4| 0| 9| 4| 4| 0| 3| 0| 2| 0| 0| 4| 4| 4| 0| 0| 2| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    79 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Leukemia Mononuclear                 |                   X                                                      |             
      Pars Distalis, Adenoma               |             X  X  X     X        X     X  X  X  X           X            |             
      Pars Distalis, Adenoma, Multiple     |       X                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      C-Cell, Adenoma                      |                                        X  X        X              X      |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  M  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Adenoma                              |          X     X                                                         |             
      Carcinoma                            |                                                                          |             
      Bilateral, Adenoma                   |                                  X     X                 X               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Adenoma                              |                         X                                                |             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        |                      X  X        X     X     X           X               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Leukemia Mononuclear                 |          X        X                          X  X              X  X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M     +     +  +  +  +  +     +  +  +  +     M|             
      Leukemia Mononuclear                 |                                                                X  X      |             
      Epithelial Cell, Thymoma Benign      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 4| 7| 4| 7| 7| 7| 7| 7| 5| 3| 7| 7| 6| 5| 4|             
                             DAY ON TEST   | 4| 4| 4| 4| 9| 5| 4| 0| 4| 0| 6| 5| 6| 5| 0| 5| 5| 4| 7| 8| 5| 5| 2| 7| 1|             
                                           | 3| 3| 9| 3| 4| 0| 4| 0| 9| 4| 4| 0| 3| 0| 2| 0| 0| 4| 4| 4| 0| 0| 2| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    79 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +     +     +  M  +  M  +     M  +  +  +     +|             
      Adenocarcinoma                       |                                                                          |             
      Adenocarcinoma, Multiple             |                                        X                                 |             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         |    X        X           X        X     X     X                           |             
      Fibroadenoma, Multiple               |                   X  X                                      X            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Basal Cell Carcinoma                 |                X                                                         |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Astrocytoma Malignant                |                                                                          |             
      Granular Cell Tumor Benign           |                                                                          |             
      Leukemia Mononuclear                 |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Leukemia Mononuclear                 |          X                                                     X  X      |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                X                                                         |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic, Adrenal Gland        |                                                                          |             
      Pleura, Alveolar/Bronchiolar         |                                                                          |             
          Carcinoma, Metastatic            |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Leukemia Mononuclear                 |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 4| 7| 4| 7| 7| 7| 7| 7| 5| 3| 7| 7| 6| 5| 4|             
                             DAY ON TEST   | 4| 4| 4| 4| 9| 5| 4| 0| 4| 0| 6| 5| 6| 5| 0| 5| 5| 4| 7| 8| 5| 5| 2| 7| 1|             
                                           | 3| 3| 9| 3| 4| 0| 4| 0| 9| 4| 4| 0| 3| 0| 2| 0| 0| 4| 4| 4| 0| 0| 2| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    79 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Leukemia Mononuclear                 |          X        X                          X  X              X  X      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 5| 5| 3| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 4| 4| 7| 5| 5| 7| 6| 6| 6| 5|             
                             DAY ON TEST   | 9| 6| 7| 7| 4| 5| 5| 5| 4| 9| 4| 4| 5| 7| 7| 6| 6| 5| 7| 4| 0| 8| 5| 1| 7|             
                                           | 5| 3| 4| 4| 2| 0| 0| 0| 3| 3| 5| 4| 1| 4| 4| 3| 4| 0| 4| 9| 9| 8| 2| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    VEHICLE                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    79 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +           +  +  +  +  +  +  M  +  +              +     +  +  +  +  M   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +           +  +  +  +  +  +  +  +  +              +     +  A  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +           +  +  +  +  +  +  +  +  +              +     +  A  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +           +  +  +  +  +  +  +  +  +              +     +  A  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +           +  +  +  +  +  +  +  +  +              +     +  A  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Leukemia Mononuclear                 |                X  X        X  X     X                             X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                                          |             
      Leukemia Mononuclear                 |                               X                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                     X                             X      |             
      Acinus, Adenoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Leukemia Mononuclear                 |                               X                                   X      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Pulp, Fibroma                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                             X            |             
      Leukemia Mononuclear                 |                            X  X     X                             X      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Leukemia Mononuclear                 |                            X  X     X                                    |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Leukemia Mononuclear                 |                            X  X     X                                    |             
      Pheochromocytoma Malignant           |                      X                                                   |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +           +  +  +  +  +  +  M  +  +              +     +  +  +  +  M   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 5| 5| 3| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 4| 4| 7| 5| 5| 7| 6| 6| 6| 5|             
                             DAY ON TEST   | 9| 6| 7| 7| 4| 5| 5| 5| 4| 9| 4| 4| 5| 7| 7| 6| 6| 5| 7| 4| 0| 8| 5| 1| 7|             
                                           | 5| 3| 4| 4| 2| 0| 0| 0| 3| 3| 5| 4| 1| 4| 4| 3| 4| 0| 4| 9| 9| 8| 2| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    VEHICLE                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    79 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +           +  +  +  +  +  +  +  +  +              +     +  M  +  +  +   |             
      Leukemia Mononuclear                 |                               X                                   X      |             
      Pars Distalis, Adenoma               | X                 X        X     X                 X     X     X     X   |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      C-Cell, Adenoma                      |                                  X                                       |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Carcinoma           |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +           +  +  +  +  +  +  +  +  +              +     +  +  M  +  +   |             
      Adenoma                              |                   X     X        X                 X                 X   |             
      Carcinoma                            |                                                                          |             
      Bilateral, Adenoma                   |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Leukemia Mononuclear                 |                               X     X                             X      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                               X                                   X      |             
      Polyp Stromal                        |                   X                                            X         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Axillary, Leukemia Mononuclear       |                                                                   X      |             
      Deep Cervical, Leukemia Mononuclear  |                                     X                                    |             
      Mediastinal, Leukemia Mononuclear    |                            X  X     X                             X      |             
      Pancreatic, Leukemia Mononuclear     |                            X                                      X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Leukemia Mononuclear                 |                            X  X     X                             X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Leukemia Mononuclear                 |                            X  X     X                             X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Leukemia Mononuclear                 |                X  X        X  X     X                             X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | M           +  +  +  +  +  +  +  +  +              +     +  M  +  +  +   |             
      Leukemia Mononuclear                 |                            X  X     X                             X      |             
      Epithelial Cell, Thymoma Benign      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 5| 5| 3| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 4| 4| 7| 5| 5| 7| 6| 6| 6| 5|             
                             DAY ON TEST   | 9| 6| 7| 7| 4| 5| 5| 5| 4| 9| 4| 4| 5| 7| 7| 6| 6| 5| 7| 4| 0| 8| 5| 1| 7|             
                                           | 5| 3| 4| 4| 2| 0| 0| 0| 3| 3| 5| 4| 1| 4| 4| 3| 4| 0| 4| 9| 9| 8| 2| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    VEHICLE                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    79 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Adenocarcinoma                       |             X                                                            |             
      Adenocarcinoma, Multiple             |                                                                          |             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         | X                    X              X                                    |             
      Fibroadenoma, Multiple               |                   X              X                                       |             
                                            __________________________________________________________________________|             
   Skin                                    | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Basal Cell Carcinoma                 |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Astrocytoma Malignant                |                                                                          |             
      Granular Cell Tumor Benign           |                                                                          |             
      Leukemia Mononuclear                 |                            X  X                                   X      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Leukemia Mononuclear                 |                X           X  X     X                             X      |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                          |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic, Adrenal Gland        |                      X                                                   |             
      Pleura, Alveolar/Bronchiolar         |                                                                          |             
          Carcinoma, Metastatic            |                                                             X            |             
                                            __________________________________________________________________________|             
   Nose                                    | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Leukemia Mononuclear                 |                            X  X     X                             X      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 5| 5| 3| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 4| 4| 7| 5| 5| 7| 6| 6| 6| 5|             
                             DAY ON TEST   | 9| 6| 7| 7| 4| 5| 5| 5| 4| 9| 4| 4| 5| 7| 7| 6| 6| 5| 7| 4| 0| 8| 5| 1| 7|             
                                           | 5| 3| 4| 4| 2| 0| 0| 0| 3| 3| 5| 4| 1| 4| 4| 3| 4| 0| 4| 9| 9| 8| 2| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    VEHICLE                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    79 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Leukemia Mononuclear                 |                X  X        X  X     X                             X      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4| 4| 7| 7| 6| 5|             
                             DAY ON TEST   | 5| 5| 5| 4| 6| 6| 4| 5| 6| 5| 5| 1| 2| 1| 7| 5| 5| 5| 3| 6| 6| 5| 5| 2| 9|             
                                           | 0| 0| 0| 3| 4| 4| 4| 0| 3| 0| 0| 5| 4| 5| 4| 0| 0| 0| 9| 4| 3| 0| 0| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    79 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +        +  +     +  +  +  +  A     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +        +  +     +  +  +  +  +     M  +  +  M        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +        +  +     +  +  +  +  A     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +        +  +     +  +  +  +  A     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                      X        X  X  X  X              X                 X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Acinus, Adenoma                      |                                                 X                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Tooth                                   |       +                                                                  |             
      Pulp, Fibroma                        |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Leukemia Mononuclear                 |                                  X  X                                   X|             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                 X                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                 X                  |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |    X                                               X                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Adenoma                              |                      X                                                   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4| 4| 7| 7| 6| 5|             
                             DAY ON TEST   | 5| 5| 5| 4| 6| 6| 4| 5| 6| 5| 5| 1| 2| 1| 7| 5| 5| 5| 3| 6| 6| 5| 5| 2| 9|             
                                           | 0| 0| 0| 3| 4| 4| 4| 0| 3| 0| 0| 5| 4| 5| 4| 0| 0| 0| 9| 4| 3| 0| 0| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    79 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Pars Distalis, Adenoma               | X     X  X        X  X           X                                   X   |             
      Pars Distalis, Adenoma, Multiple     |                            X  X                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      C-Cell, Adenoma                      | X        X                    X                                          |             
      C-Cell, Carcinoma                    |                                                                         X|             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +        +  M     +  M  +  +  +     +  +  +  +        +  +  +  +|             
      Adenoma                              |    X  X                                                                  |             
      Carcinoma                            |                                                                          |             
      Bilateral, Adenoma                   |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                                        X              X                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                        X              X                  |             
      Polyp Stromal                        |                            X                                   X        X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                     +                 +                  |             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                  X                    X                 X|             
      Pancreatic, Leukemia Mononuclear     |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        M  +  M  +|             
      Leukemia Mononuclear                 |                                  X     X              X                 X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                                  X     X              X                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                      X        X  X  X  X              X                 X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +        M  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                    X                 X|             
      Epithelial Cell, Thymoma Benign      |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4| 4| 7| 7| 6| 5|             
                             DAY ON TEST   | 5| 5| 5| 4| 6| 6| 4| 5| 6| 5| 5| 1| 2| 1| 7| 5| 5| 5| 3| 6| 6| 5| 5| 2| 9|             
                                           | 0| 0| 0| 3| 4| 4| 4| 0| 3| 0| 0| 5| 4| 5| 4| 0| 0| 0| 9| 4| 3| 0| 0| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    79 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Adenocarcinoma                       |                               X                                          |             
      Adenocarcinoma, Multiple             |                                                                          |             
      Adenoma                              |                   X                                                      |             
      Fibroadenoma                         | X     X  X        X           X                    X  X           X      |             
      Fibroadenoma, Multiple               |    X                 X                          X                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Basal Cell Carcinoma                 |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Astrocytoma Malignant                |                            X                                             |             
      Granular Cell Tumor Benign           |    X                                                                     |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                               X                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                         X|             
      Leukemia Mononuclear                 |                                  X  X  X              X                 X|             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                          |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic, Adrenal Gland        |                                                                          |             
      Pleura, Alveolar/Bronchiolar         |                                                                          |             
          Carcinoma, Metastatic            |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +  +                    +                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +  +                    +                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                    X                 X|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4| 4| 7| 7| 6| 5|             
                             DAY ON TEST   | 5| 5| 5| 4| 6| 6| 4| 5| 6| 5| 5| 1| 2| 1| 7| 5| 5| 5| 3| 6| 6| 5| 5| 2| 9|             
                                           | 0| 0| 0| 3| 4| 4| 4| 0| 3| 0| 0| 5| 4| 5| 4| 0| 0| 0| 9| 4| 3| 0| 0| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    79 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                      X        X  X  X  X              X                 X|             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5|                                                           |            |
                             DAY ON TEST   | 5| 5| 4| 0| 7|                                                           |            |
                                           | 0| 0| 4| 7| 4|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6|                                                           |     A      |
    VEHICLE                                | 4| 4| 4| 4| 4|                                                           |     L      |
    79 VF                                  | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +                                                               |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +                                                               |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +                                                               |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +                                                               |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +                                                               |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +                                                               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +                                                               |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +                                                               |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +                                                               |  58        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +                                                               |  60        |
      Leukemia Mononuclear                 | X        X                                                               |         21 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +                                                               |  60        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Acinus, Adenoma                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +                                                               |  60        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +                                                               |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +                                                               |  60        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +                                                               |  60        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Pulp, Fibroma                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +                                                               |  60        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Leukemia Mononuclear                 |          X                                                               |          9 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +                                                               |  59        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +                                                               |  59        |
      Leukemia Mononuclear                 |                                                                          |          6 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +                                                               |  58        |
      Leukemia Mononuclear                 |                                                                          |          7 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  14                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5|                                                           |            |
                             DAY ON TEST   | 5| 5| 4| 0| 7|                                                           |            |
                                           | 0| 0| 4| 7| 4|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6|                                                           |     A      |
    VEHICLE                                | 4| 4| 4| 4| 4|                                                           |     L      |
    79 VF                                  | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              | X                                                                        |          6 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +                                                               |  59        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M                                                               |  55        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +                                                               |  59        |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Pars Distalis, Adenoma               | X                                                                        |         26 |
      Pars Distalis, Adenoma, Multiple     |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +                                                               |  60        |
      C-Cell, Adenoma                      | X                                                                        |          9 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +                                                               |  56        |
      Adenoma                              |                                                                          |          9 |
      Carcinoma                            | X                                                                        |          1 |
      Bilateral, Adenoma                   |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  M                                                               |  58        |
      Leukemia Mononuclear                 |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +                                                               |  60        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Polyp Stromal                        |                                                                          |         11 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   2        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +                                                               |  59        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +                                                               |  60        |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          7 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  15                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5|                                                           |            |
                             DAY ON TEST   | 5| 5| 4| 0| 7|                                                           |            |
                                           | 0| 0| 4| 7| 4|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6|                                                           |     A      |
    VEHICLE                                | 4| 4| 4| 4| 4|                                                           |     L      |
    79 VF                                  | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  M                                                               |  56        |
      Leukemia Mononuclear                 |                                                                          |          8 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +                                                               |  60        |
      Leukemia Mononuclear                 |          X                                                               |          9 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +                                                               |  60        |
      Leukemia Mononuclear                 | X        X                                                               |         21 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +                                                               |  55        |
      Leukemia Mononuclear                 |                                                                          |          9 |
      Epithelial Cell, Thymoma Benign      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +                                                               |  56        |
      Adenocarcinoma                       |                                                                          |          2 |
      Adenocarcinoma, Multiple             |                                                                          |          1 |
      Adenoma                              |                                                                          |          1 |
      Fibroadenoma                         |                                                                          |         17 |
      Fibroadenoma, Multiple               | X                                                                        |          9 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +                                                               |  60        |
      Basal Cell Carcinoma                 |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +                                                               |  60        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +                                                               |  60        |
      Astrocytoma Malignant                |                                                                          |          1 |
      Granular Cell Tumor Benign           |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +                                                               |  60        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |    X                                                                     |          1 |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
      Leukemia Mononuclear                 | X        X                                                               |         15 |
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
      Pheochromocytoma Malignant,          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  16                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5|                                                           |            |
                             DAY ON TEST   | 5| 5| 4| 0| 7|                                                           |            |
                                           | 0| 0| 4| 7| 4|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6|                                                           |     A      |
    VEHICLE                                | 4| 4| 4| 4| 4|                                                           |     L      |
    79 VF                                  | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
          Metastatic, Adrenal Gland        |                                                                          |          1 |
      Pleura, Alveolar/Bronchiolar         |                                                                          |            |
          Carcinoma, Metastatic            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +                                                               |  60        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +                                                               |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                                               |   5        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +                                                               |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +                                                               |  60        |
      Leukemia Mononuclear                 |                                                                          |          8 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +                                                               |  60        |
      Leukemia Mononuclear                 |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +                                                               |  60        |
      Leukemia Mononuclear                 | X        X                                                               |         21 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  17                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 1| 7| 7| 7| 5| 5| 7| 7| 7| 4| 6| 7| 4| 7| 7| 5| 7| 4| 7| 6| 5|             
                             DAY ON TEST   | 4| 4| 4| 7| 7| 4| 4| 4| 9| 7| 4| 4| 2| 6| 3| 4| 6| 4| 0| 4| 4| 6| 4| 4| 7|             
                                           | 9| 9| 3| 4| 7| 9| 9| 9| 0| 4| 9| 9| 1| 4| 9| 9| 4| 4| 7| 9| 9| 4| 9| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.025 G/                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    KG 79 LF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +     +  +  +     +  M     +  +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     A  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     A  +  +  +  +     +  +  +     +  +     +  +  A  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     A  +  +  +  +     +  +  +     +  +     +  +  A  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     A  +  +  +  +     +  +  +     +  +     +  +  A  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     A  +  +  +  +     +  +  +     +  +     +  +  A  +     +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Leukemia Mononuclear                 | X  X                    X        X  X              X  X              X   |             
      Neoplastic Nodule                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Leukemia Mononuclear                 |                         X           X                                    |             
      Acinus, Adenoma                      |       X                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Squamous Cell Papilloma              |    X                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Leukemia Mononuclear                 |                                     X              X                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Leukemia Mononuclear                 |                         X           X              X                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Leukemia Mononuclear                 |                         X           X              X                     |             
      Pheochromocytoma Benign              |                                     X        X     X                     |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Adenoma, Multiple                    |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +     M  +  +  +  +     +  +  +     +  +     +  +  M  +     M  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +  M     +  +  +     +  +     +  +  +  +     +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               | X  X  X        X  X  X        X           X        X              X  X   |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     A  +  +  +  +     +  +  +     +  +     +  +  A  +     +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 1| 7| 7| 7| 5| 5| 7| 7| 7| 4| 6| 7| 4| 7| 7| 5| 7| 4| 7| 6| 5|             
                             DAY ON TEST   | 4| 4| 4| 7| 7| 4| 4| 4| 9| 7| 4| 4| 2| 6| 3| 4| 6| 4| 0| 4| 4| 6| 4| 4| 7|             
                                           | 9| 9| 3| 4| 7| 9| 9| 9| 0| 4| 9| 9| 1| 4| 9| 9| 4| 4| 7| 9| 9| 4| 9| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.025 G/                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    KG 79 LF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      Bilateral, C-Cell, Carcinoma         |                                                                   X      |             
      C-Cell, Adenoma                      |                                     X              X                     |             
      C-Cell, Carcinoma                    |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +     +  +  +  +  +     +  +  +     +  +     +  M  +  +     +  +   |             
      Adenoma                              |                X        X                                                |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Leukemia Mononuclear                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        |                X              X                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                         X                          X                     |             
      Pancreatic, Leukemia Mononuclear     | X                                                                    X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  M   |             
      Leukemia Mononuclear                 |                         X                          X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Leukemia Mononuclear                 |                         X                          X                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Leukemia Mononuclear                 | X  X                    X        X  X              X  X              X   |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Leukemia Mononuclear                 | X                       X                          X                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     M  +  +  +  +     +  +  +     +  +     +  +  +  M     +  +   |             
      Adenocarcinoma                       |                                                                          |             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         | X  X  X           X                       X        X                     |             
      Fibroadenoma, Multiple               |                                  X                                       |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Subcutaneous Tissue, Fibroma         |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 1| 7| 7| 7| 5| 5| 7| 7| 7| 4| 6| 7| 4| 7| 7| 5| 7| 4| 7| 6| 5|             
                             DAY ON TEST   | 4| 4| 4| 7| 7| 4| 4| 4| 9| 7| 4| 4| 2| 6| 3| 4| 6| 4| 0| 4| 4| 6| 4| 4| 7|             
                                           | 9| 9| 3| 4| 7| 9| 9| 9| 0| 4| 9| 9| 1| 4| 9| 9| 4| 4| 7| 9| 9| 4| 9| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.025 G/                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    KG 79 LF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Leukemia Mononuclear                 |    X                    X        X  X              X  X                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  A  +     +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                           +                              |             
                                            __________________________________________________________________________|             
   Eye                                     |                                     +     +                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                     +     +                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Leukemia Mononuclear                 |                                                    X                     |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Leukemia Mononuclear                 |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Leukemia Mononuclear                 | X  X                    X        X  X              X  X              X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 5| 5| 7| 6| 4| 6| 4| 7| 6| 5| 5| 4| 7| 7| 4| 6| 5| 7| 4| 7| 7| 5|             
                             DAY ON TEST   | 9| 9| 6| 9| 7| 2| 8| 6| 3| 5| 4| 1| 7| 7| 6| 4| 4| 6| 0| 1| 4| 6| 4| 4| 7|             
                                           | 4| 2| 0| 5| 0| 1| 8| 3| 1| 1| 9| 0| 4| 4| 4| 9| 9| 3| 8| 0| 9| 3| 9| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.025 G/                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    KG 79 LF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +     +  A  +  +        +  +  +     +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +     +  A  +  +        +  +  +     A  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +     +  A  +  +        +  +  +     +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +     +  A  +  +        +  +  +     +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  A  +  +     +  A  +  +        +  +  +     +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +     +  A  +  +        +  +  +     +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +     +  A  +  +        +  +  +     A  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +     +  A  +  +        +  +  +     A  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Leukemia Mononuclear                 | X  X  X     X  X                 X                                       |             
      Neoplastic Nodule                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                      +                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Leukemia Mononuclear                 | X                                                                        |             
      Acinus, Adenoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Leukemia Mononuclear                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +     +  A  +  +        +  +  +     +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +     +  A  +  +        +  +  +     +  +  +     +  +   |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +     +  A  +  +        +  +  +     +  +  +     +  +   |             
      Leukemia Mononuclear                 | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Leukemia Mononuclear                 | X           X  X                 X                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Leukemia Mononuclear                 |       X     X                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +     +  +  +  M        +  +  +     +  +  +     +  +   |             
      Leukemia Mononuclear                 |       X     X                                                            |             
      Pheochromocytoma Benign              |                X                                            X            |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Adenoma, Multiple                    |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +     +  +  M  +        +  +  +     +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Leukemia Mononuclear                 | X                                                                        |             
      Pars Distalis, Adenoma               |          X              X     X                 X     X              X   |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +     +  A  +  +        +  +  +     A  +  +     +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 5| 5| 7| 6| 4| 6| 4| 7| 6| 5| 5| 4| 7| 7| 4| 6| 5| 7| 4| 7| 7| 5|             
                             DAY ON TEST   | 9| 9| 6| 9| 7| 2| 8| 6| 3| 5| 4| 1| 7| 7| 6| 4| 4| 6| 0| 1| 4| 6| 4| 4| 7|             
                                           | 4| 2| 0| 5| 0| 1| 8| 3| 1| 1| 9| 0| 4| 4| 4| 9| 9| 3| 8| 0| 9| 3| 9| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.025 G/                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    KG 79 LF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 | X                                                                        |             
      Bilateral, C-Cell, Adenoma           |                                                 X                        |             
      Bilateral, C-Cell, Carcinoma         |                               X                                          |             
      C-Cell, Adenoma                      |                         X                                                |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Adenoma                              |          X                                               X               |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Leukemia Mononuclear                 | X           X  X                                                         |             
      Polyp Stromal                        |          X  X  X                             X              X            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                X                 X                                       |             
      Pancreatic, Leukemia Mononuclear     |             X  X                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +     +  +  M  +        +  +  +     +  +  +     +  +   |             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Leukemia Mononuclear                 |             X                    X                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +     +  +  +  +        +  +  +     M  +  +     +  +   |             
      Leukemia Mononuclear                 | X  X  X     X  X                 X                                       |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +     +  +  +  +        +  M  +     +  +  +     +  +   |             
      Leukemia Mononuclear                 | X           X                    X                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +     +  +  +  +        +  +  M     +  +  +     +  +   |             
      Adenocarcinoma                       |                                                                          |             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         | X     X        X              X              X                           |             
      Fibroadenoma, Multiple               |                         X                                   X            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 5| 5| 7| 6| 4| 6| 4| 7| 6| 5| 5| 4| 7| 7| 4| 6| 5| 7| 4| 7| 7| 5|             
                             DAY ON TEST   | 9| 9| 6| 9| 7| 2| 8| 6| 3| 5| 4| 1| 7| 7| 6| 4| 4| 6| 0| 1| 4| 6| 4| 4| 7|             
                                           | 4| 2| 0| 5| 0| 1| 8| 3| 1| 1| 9| 0| 4| 4| 4| 9| 9| 3| 8| 0| 9| 3| 9| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.025 G/                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    KG 79 LF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Carcinoma, Metastatic, Thyroid Gland |                               X                                          |             
      Leukemia Mononuclear                 | X     X     X  X                 X                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +     +  +  +  +        +  +  +     A  +  +     +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Leukemia Mononuclear                 |       X     X                    X                                       |             
      Renal Tubule, Adenoma                |    X                                                                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +     +  A  +  +        +     +     A  +  +     +  +   |             
      Leukemia Mononuclear                 |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Leukemia Mononuclear                 | X  X  X     X  X                 X                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 7| 6| 7| 4| 6| 5| 3| 4| 7| 6| 5| 5| 7| 7| 6| 5| 4| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 6| 4| 6| 1| 4| 4| 6| 6| 7| 5| 6| 4| 4| 7| 0| 4| 4| 4| 7| 3| 4| 4| 4| 8| 4|             
                                           | 3| 4| 3| 5| 3| 3| 3| 1| 4| 0| 3| 3| 5| 4| 4| 9| 9| 5| 4| 0| 4| 9| 3| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.025 G/                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    KG 79 LF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X                                X                       X   |             
      Neoplastic Nodule                    |                                                                X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +     +     +     +                  |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Acinus, Adenoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                           X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                X                           |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                X                           |             
      Pheochromocytoma Benign              |                                                                         X|             
      Bilateral, Pheochromocytoma Benign   |                                                                   X      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma, Multiple                    |                                              X                           |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +     +  +  +     +     +     M  +     +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
      Pars Distalis, Adenoma               |             X                       X                 X                  |             
      Pars Distalis, Adenoma, Multiple     |                                  X                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 7| 6| 7| 4| 6| 5| 3| 4| 7| 6| 5| 5| 7| 7| 6| 5| 4| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 6| 4| 6| 1| 4| 4| 6| 6| 7| 5| 6| 4| 4| 7| 0| 4| 4| 4| 7| 3| 4| 4| 4| 8| 4|             
                                           | 3| 4| 3| 5| 3| 3| 3| 1| 4| 0| 3| 3| 5| 4| 4| 9| 9| 5| 4| 0| 4| 9| 3| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.025 G/                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    KG 79 LF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      Bilateral, C-Cell, Carcinoma         |                                                                          |             
      C-Cell, Adenoma                      |          X                                                  X     X  X   |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +     +  +  +     M     +     +  +     +  +  +  M  +  +  +  +  +  M  +|             
      Adenoma                              |          X                                      X                        |             
      Carcinoma                            |                                                                   X      |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        |    X                                               X                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                              X                           |             
      Mediastinal, Leukemia Mononuclear    |                                              X                           |             
      Pancreatic, Leukemia Mononuclear     |                                              X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X                                X  X                    X   |             
      Sarcoma                              |                X                                                         |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +     +  +  +     M     +     +  +     +  +  +  M  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  M  +  +  +|             
      Adenocarcinoma                       |                            X                                             |             
      Adenoma                              |                                                       X                  |             
      Fibroadenoma                         |    X                                X     X        X                 X   |             
      Fibroadenoma, Multiple               |                      X                       X                    X      |             
                                            __________________________________________________________________________|             
   Skin                                    |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 7| 6| 7| 4| 6| 5| 3| 4| 7| 6| 5| 5| 7| 7| 6| 5| 4| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 6| 4| 6| 1| 4| 4| 6| 6| 7| 5| 6| 4| 4| 7| 0| 4| 4| 4| 7| 3| 4| 4| 4| 8| 4|             
                                           | 3| 4| 3| 5| 3| 3| 3| 1| 4| 0| 3| 3| 5| 4| 4| 9| 9| 5| 4| 0| 4| 9| 3| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.025 G/                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    KG 79 LF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                  X                                       |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Leukemia Mononuclear                 |          X  X                                X                       X   |             
                                            __________________________________________________________________________|             
   Nose                                    |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +        +     +                       +     +  +  +     +   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +        +                             +     +  +  +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                   X                           |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X                                X  X                    X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5|                                                           |            |
                             DAY ON TEST   | 4| 4| 4| 3| 7|                                                           |            |
                                           | 4| 4| 9| 9| 4|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8|                                                           |     A      |
    0.025 G/                               | 0| 0| 0| 0| 0|                                                           |     L      |
    KG 79 LF                               | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +                                                               |  61        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +                                                               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +                                                               |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +                                                               |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +                                                               |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +                                                               |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +                                                               |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +                                                               |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +                                                               |  56        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +                                                               |  61        |
      Leukemia Mononuclear                 |    X                                                                     |         19 |
      Neoplastic Nodule                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +        +                                                               |   9        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +                                                               |  61        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Acinus, Adenoma                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +                                                               |  61        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +                                                               |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +                                                               |  60        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +                                                               |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +                                                               |  61        |
      Leukemia Mononuclear                 |                                                                          |          8 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +                                                               |  61        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +                                                               |  61        |
      Leukemia Mononuclear                 |                                                                          |          7 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +                                                               |  60        |
      Leukemia Mononuclear                 |                                                                          |          7 |
      Pheochromocytoma Benign              |                                                                          |          6 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +                                                               |  61        |
      Adenoma, Multiple                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M                                                               |  53        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  27                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5|                                                           |            |
                             DAY ON TEST   | 4| 4| 4| 3| 7|                                                           |            |
                                           | 4| 4| 9| 9| 4|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8|                                                           |     A      |
    0.025 G/                               | 0| 0| 0| 0| 0|                                                           |     L      |
    KG 79 LF                               | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +                                                               |  59        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Pars Distalis, Adenoma               | X     X                                                                  |         22 |
      Pars Distalis, Adenoma, Multiple     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +                                                               |  57        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Bilateral, C-Cell, Adenoma           |                                                                          |          1 |
      Bilateral, C-Cell, Carcinoma         |                                                                          |          2 |
      C-Cell, Adenoma                      |                                                                          |          7 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  M                                                               |  55        |
      Adenoma                              | X  X                                                                     |          8 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +                                                               |  61        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +                                                               |  61        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Polyp Stromal                        |          X                                                               |         10 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +                                                               |  61        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +                                                               |  61        |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          5 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +                                                               |  59        |
      Leukemia Mononuclear                 |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +                                                               |  61        |
      Leukemia Mononuclear                 |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +                                                               |  60        |
      Leukemia Mononuclear                 |    X                                                                     |         20 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +                                                               |  56        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  28                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5|                                                           |            |
                             DAY ON TEST   | 4| 4| 4| 3| 7|                                                           |            |
                                           | 4| 4| 9| 9| 4|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8|                                                           |     A      |
    0.025 G/                               | 0| 0| 0| 0| 0|                                                           |     L      |
    KG 79 LF                               | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |    X                                                                     |          8 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +                                                               |  56        |
      Adenocarcinoma                       |                                                                          |          1 |
      Adenoma                              |                                                                          |          1 |
      Fibroadenoma                         |          X                                                               |         17 |
      Fibroadenoma, Multiple               |       X                                                                  |          7 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +                                                               |  61        |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +                                                               |  61        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +                                                               |  61        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +                                                               |  61        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
      Leukemia Mononuclear                 |    X                                                                     |         16 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +                                                               |  61        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +                                                               |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |  11        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   8        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +                                                               |  61        |
      Leukemia Mononuclear                 |                                                                          |          6 |
      Renal Tubule, Adenoma                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +                                                               |  58        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +                                                               |  61        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  29                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5|                                                           |            |
                             DAY ON TEST   | 4| 4| 4| 3| 7|                                                           |            |
                                           | 4| 4| 9| 9| 4|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8|                                                           |     A      |
    0.025 G/                               | 0| 0| 0| 0| 0|                                                           |     L      |
    KG 79 LF                               | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |    X                                                                     |         20 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  30                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 5| 4| 3| 2| 7| 7| 5| 4| 5| 7| 7| 5| 4| 4| 7| 7| 5| 4| 3|             
                             DAY ON TEST   | 4| 4| 4| 6| 7| 4| 7| 6| 3| 3| 4| 4| 7| 5| 7| 4| 4| 7| 6| 9| 4| 4| 7| 5| 0|             
                                           | 8| 8| 2| 5| 4| 4| 4| 3| 8| 4| 8| 8| 4| 7| 4| 8| 8| 4| 4| 3| 8| 8| 5| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.05 G/K                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G 79 HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  A  +  +|             
      Leiomyosarcoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 | X        X                                                     X         |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                               +              +     +   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Acinus, Adenoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Palate, Squamous Cell Papilloma      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
      Squamous Cell Papilloma              |    X                                                           X         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                     X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                     X         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                     X         |             
      Pheochromocytoma Benign              |                                                                          |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +     +        +  +  +  +     +     M  +        +  +  +  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 5| 4| 3| 2| 7| 7| 5| 4| 5| 7| 7| 5| 4| 4| 7| 7| 5| 4| 3|             
                             DAY ON TEST   | 4| 4| 4| 6| 7| 4| 7| 6| 3| 3| 4| 4| 7| 5| 7| 4| 4| 7| 6| 9| 4| 4| 7| 5| 0|             
                                           | 8| 8| 2| 5| 4| 4| 4| 3| 8| 4| 8| 8| 4| 7| 4| 8| 8| 4| 4| 3| 8| 8| 5| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.05 G/K                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G 79 HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma               |                                              X  X                 X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  M|             
      C-Cell, Adenoma                      |                                                                          |             
      Follicular Cell, Adenoma, Multiple   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                   +      |             
      Sarcoma                              |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  M|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                     X         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Polyp Stromal                        |    X  X                                      X  X                        |             
      Bilateral, Polyp Stromal             |                                                                          |             
      Cervix, Sarcoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |          X                                                     X         |             
      Pancreatic, Leukemia Mononuclear     |          X                                                     X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                     X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                     X         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X        X                                                     X         |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     +        +  M  +  +     +     +  +        +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                     X         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +     +        +  +  M  +     M     M  +        +  +  +  M  M  M|             
      Fibroadenoma                         | X                                X              X                        |             
      Fibroadenoma, Multiple               |                                                                X         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  M|             
      Subcutaneous Tissue, Sarcoma         |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 5| 4| 3| 2| 7| 7| 5| 4| 5| 7| 7| 5| 4| 4| 7| 7| 5| 4| 3|             
                             DAY ON TEST   | 4| 4| 4| 6| 7| 4| 7| 6| 3| 3| 4| 4| 7| 5| 7| 4| 4| 7| 6| 9| 4| 4| 7| 5| 0|             
                                           | 8| 8| 2| 5| 4| 4| 4| 3| 8| 4| 8| 8| 4| 7| 4| 8| 8| 4| 4| 3| 8| 8| 5| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.05 G/K                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G 79 HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Granular Cell Tumor Benign           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |             
      Leukemia Mononuclear                 |          X                                                     X         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +                    +           +                                 |             
                                            __________________________________________________________________________|             
   Eye                                     |       +  +              +  +                 +  +        +  +            |             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +  +              +                       +        +  +            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                     X         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X        X                                                     X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 6| 2| 7| 7| 7| 6| 4| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 4| 7| 7| 6| 3|             
                             DAY ON TEST   | 6| 6| 4| 1| 3| 4| 4| 4| 6| 9| 4| 8| 7| 5| 2| 4| 4| 4| 7| 7| 6| 4| 4| 9| 4|             
                                           | 3| 4| 8| 7| 2| 3| 9| 9| 5| 3| 4| 3| 3| 3| 1| 4| 9| 9| 4| 4| 4| 8| 8| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    0.05 G/K                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    G 79 HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +        +  +  +  +|             
      Leiomyosarcoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Hepatocellular Adenoma               |                X                                                  X      |             
      Leukemia Mononuclear                 |                X              X  X                    X                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                            +     +   |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                X                                      X                  |             
      Acinus, Adenoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Palate, Squamous Cell Papilloma      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                X                                      X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                X                                      X                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Pheochromocytoma Benign              |                                                                      X   |             
      Bilateral, Pheochromocytoma Benign   |                                                       X                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 6| 2| 7| 7| 7| 6| 4| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 4| 7| 7| 6| 3|             
                             DAY ON TEST   | 6| 6| 4| 1| 3| 4| 4| 4| 6| 9| 4| 8| 7| 5| 2| 4| 4| 4| 7| 7| 6| 4| 4| 9| 4|             
                                           | 3| 4| 8| 7| 2| 3| 9| 9| 5| 3| 4| 3| 3| 3| 1| 4| 9| 9| 4| 4| 4| 8| 8| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    0.05 G/K                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    G 79 HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma               |                X              X     X        X  X  X              X  X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      C-Cell, Adenoma                      |                               X        X     X     X              X      |             
      Follicular Cell, Adenoma, Multiple   |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |       +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Adenoma                              |                                                    X                     |             
                                            __________________________________________________________________________|             
   Ovary                                   |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Polyp Stromal                        |                   X  X     X           X           X           X         |             
      Bilateral, Polyp Stromal             |                                                                   X      |             
      Cervix, Sarcoma                      |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                                       X                  |             
      Mediastinal, Leukemia Mononuclear    |                                                       X                  |             
      Pancreatic, Leukemia Mononuclear     |                X                                      X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                X                                      X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                X              X  X                    X        X         |             
      Sarcoma                              |                         X                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                X                                      X                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Fibroadenoma                         |       X  X     X                                X                 X      |             
      Fibroadenoma, Multiple               |                         X                                                |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 6| 2| 7| 7| 7| 6| 4| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 4| 7| 7| 6| 3|             
                             DAY ON TEST   | 6| 6| 4| 1| 3| 4| 4| 4| 6| 9| 4| 8| 7| 5| 2| 4| 4| 4| 7| 7| 6| 4| 4| 9| 4|             
                                           | 3| 4| 8| 7| 2| 3| 9| 9| 5| 3| 4| 3| 3| 3| 1| 4| 9| 9| 4| 4| 4| 8| 8| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    0.05 G/K                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    G 79 HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Granular Cell Tumor Benign           |                                                                      X   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                              X                           |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                   X      |             
      Carcinoma, Metastatic, Zymbal's Gland|                               X                                          |             
      Leukemia Mononuclear                 |                X                                      X                  |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                               +           +                              |             
                                            __________________________________________________________________________|             
   Eye                                     |                +              +  +  +                                +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +              +  +                                   +   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                               +                                          |             
      Carcinoma                            |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Leukemia Mononuclear                 |                X              X  X                    X        X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 4| 7| 5| 5| 6| 6| 6| 4| 4| 4| 7| 7| 7| 7| 7| 7| 5| 4| 4|             
                             DAY ON TEST   | 4| 4| 4| 4| 9| 4| 6| 4| 7| 7| 9| 4| 3| 6| 1| 6| 4| 4| 4| 4| 4| 4| 7| 8| 7|             
                                           | 3| 9| 4| 3| 6| 9| 4| 3| 4| 4| 4| 3| 9| 4| 5| 4| 9| 9| 8| 4| 8| 3| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.05 G/K                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G 79 HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  A|             
      Leiomyosarcoma                       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  M  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 |                X     X                          X  X  X     X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +  +                                                     +         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                 X                        |             
      Acinus, Adenoma                      |                      X                                                   |             
                                            __________________________________________________________________________|             
   Pharynx                                 |       +                                                                  |             
      Palate, Squamous Cell Papilloma      |       X                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                 X     X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                 X     X                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +     +        +  +  +     +     +  +  M  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                 X                        |             
      Pheochromocytoma Benign              |          X           X                                   X               |             
      Bilateral, Pheochromocytoma Benign   |                                                    X                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                X                                      X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 4| 7| 5| 5| 6| 6| 6| 4| 4| 4| 7| 7| 7| 7| 7| 7| 5| 4| 4|             
                             DAY ON TEST   | 4| 4| 4| 4| 9| 4| 6| 4| 7| 7| 9| 4| 3| 6| 1| 6| 4| 4| 4| 4| 4| 4| 7| 8| 7|             
                                           | 3| 9| 4| 3| 6| 9| 4| 3| 4| 4| 4| 3| 9| 4| 5| 4| 9| 9| 8| 4| 8| 3| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.05 G/K                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G 79 HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma               |       X                       X  X  X                       X            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      C-Cell, Adenoma                      |    X                                                  X                  |             
      Follicular Cell, Adenoma, Multiple   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  M  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Adenoma                              |                                                                      X   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Polyp Stromal                        |                                  X  X              X  X                  |             
      Bilateral, Polyp Stromal             |                                                                X         |             
      Cervix, Sarcoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                                 X                        |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                X                                X     X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                X                                X                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                X     X                          X  X  X     X            |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M     +        +  +  +     +     +  +  +  M  +  M     M  +|             
      Fibroadenoma                         | X  X        X        X        X                    X        X            |             
      Fibroadenoma, Multiple               |       X                                                                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  M  +     +  +|             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 4| 7| 5| 5| 6| 6| 6| 4| 4| 4| 7| 7| 7| 7| 7| 7| 5| 4| 4|             
                             DAY ON TEST   | 4| 4| 4| 4| 9| 4| 6| 4| 7| 7| 9| 4| 3| 6| 1| 6| 4| 4| 4| 4| 4| 4| 7| 8| 7|             
                                           | 3| 9| 4| 3| 6| 9| 4| 3| 4| 4| 4| 3| 9| 4| 5| 4| 9| 9| 8| 4| 8| 3| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.05 G/K                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G 79 HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Granular Cell Tumor Benign           |                                                                          |             
      Leukemia Mononuclear                 |                X                                      X                  |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |             
      Leukemia Mononuclear                 |                X                                X     X                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                     +                                    |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                    +                    +  +        +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                    +                    +  +            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                 X     X                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |                X     X                          X  X  X     X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 4| 3| 2|                                                           |            |
                             DAY ON TEST   | 7| 6| 6| 4| 4|                                                           |            |
                                           | 4| 4| 3| 4| 7|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9|                                                           |     A      |
    0.05 G/K                               | 6| 6| 6| 6| 6|                                                           |     L      |
    G 79 HF                                | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +  +                                                            |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +  +                                                            |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +  +                                                            |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +  +                                                            |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +  +                                                            |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |          +  +                                                            |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +  +                                                            |  56        |
      Leiomyosarcoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +  +                                                            |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +  +                                                            |  56        |
                                            __________________________________________________________________________|____________|
   Liver                                   |          +  +                                                            |  60        |
      Hepatocellular Adenoma               |                                                                          |          2 |
      Leukemia Mononuclear                 |          X                                                               |         14 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |  10        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |          +  +                                                            |  59        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Acinus, Adenoma                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Palate, Squamous Cell Papilloma      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +  +                                                            |  60        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 |          +  +                                                            |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +  +                                                            |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +  +                                                            |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +  +                                                            |  60        |
      Leukemia Mononuclear                 |          X                                                               |          7 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |          +  +                                                            |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |          +  +                                                            |  60        |
      Leukemia Mononuclear                 |                                                                          |          6 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |          +  +                                                            |  59        |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Pheochromocytoma Benign              |                                                                          |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  40                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 4| 3| 2|                                                           |            |
                             DAY ON TEST   | 7| 6| 6| 4| 4|                                                           |            |
                                           | 4| 4| 3| 4| 7|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9|                                                           |     A      |
    0.05 G/K                               | 6| 6| 6| 6| 6|                                                           |     L      |
    G 79 HF                                | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +  +                                                            |  59        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          M  M                                                            |  51        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          +  +                                                            |  60        |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Pars Distalis, Adenoma               |                                                                          |         16 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +  +                                                            |  59        |
      C-Cell, Adenoma                      |                                                                          |          7 |
      Follicular Cell, Adenoma, Multiple   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Sarcoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |          +  +                                                            |  56        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Ovary                                   |          +  +                                                            |  60        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |          +  +                                                            |  60        |
      Polyp Stromal                        |                                                                          |         14 |
      Bilateral, Polyp Stromal             |                                                                          |          2 |
      Cervix, Sarcoma                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +  +                                                            |  59        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +  +                                                            |  60        |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          4 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +  +                                                            |  60        |
      Leukemia Mononuclear                 |                                                                          |          7 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +  +                                                            |  60        |
      Leukemia Mononuclear                 |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |          +  +                                                            |  60        |
      Leukemia Mononuclear                 |          X                                                               |         15 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +  +                                                            |  58        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  41                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 4| 3| 2|                                                           |            |
                             DAY ON TEST   | 7| 6| 6| 4| 4|                                                           |            |
                                           | 4| 4| 3| 4| 7|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9|                                                           |     A      |
    0.05 G/K                               | 6| 6| 6| 6| 6|                                                           |     L      |
    G 79 HF                                | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                          |          5 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          +  +                                                            |  49        |
      Fibroadenoma                         |                                                                          |         15 |
      Fibroadenoma, Multiple               |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Skin                                    |          +  +                                                            |  58        |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +  +                                                            |  60        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +  +                                                            |  60        |
      Granular Cell Tumor Benign           |                                                                          |          1 |
      Leukemia Mononuclear                 |          X                                                               |          3 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |          +  +                                                            |  60        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |          1 |
      Leukemia Mononuclear                 |          X                                                               |          8 |
                                            __________________________________________________________________________|____________|
   Nose                                    |          +  +                                                            |  60        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +  +                                                            |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   6        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |  18        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |  14        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |          +  +                                                            |  60        |
      Leukemia Mononuclear                 |          X                                                               |          6 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  42                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 4| 3| 2|                                                           |            |
                             DAY ON TEST   | 7| 6| 6| 4| 4|                                                           |            |
                                           | 4| 4| 3| 4| 7|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9|                                                           |     A      |
    0.05 G/K                               | 6| 6| 6| 6| 6|                                                           |     L      |
    G 79 HF                                | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +  +                                                            |  60        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |          +  +                                                            |  60        |
      Leukemia Mononuclear                 |          X                                                               |         15 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  43                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 5| 7| 7| 7| 7| 5| 7| 4| 6| 4| 5| 7| 7| 7| 5| 5| 4| 7| 7| 6| 5|             
                             DAY ON TEST   | 4| 4| 2| 5| 5| 4| 4| 3| 3| 7| 3| 5| 5| 5| 7| 4| 4| 4| 7| 7| 5| 4| 1| 4| 7|             
                                           | 4| 4| 2| 8| 0| 5| 5| 9| 8| 6| 8| 8| 9| 7| 8| 5| 5| 5| 7| 6| 7| 4| 7| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    79VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +  +  +     +     A     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     A  +  +  +  +     +     A     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +     +     A     +  +  +  +  +        +  +  +   |             
      Lymphoid Tissue, Leukemia Mononuclear|                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     A  +  +  +  +     +     A     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     A  +  +  +  +     +     A     +  +  +  +  +        +  +  +   |             
      Lymphoid Tissue, Leukemia Mononuclear|                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     A  +  +  +  +     +     A     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 |                X  X                       X                       X  X   |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +                                                                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  M  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Leukemia Mononuclear                 |                                                                   X  X   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     A  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Leukemia Mononuclear                 |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Leukemia Mononuclear                 |                X  X                       X                       X      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Leukemia Mononuclear                 |                X  X                       X                       X      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Leukemia Mononuclear                 |                X  X                       X                       X      |             
      Pheochromocytoma Malignant           |                   X                                                      |             
      Pheochromocytoma Benign              |                X                                X  X                     |             
      Bilateral, Pheochromocytoma Benign   | X                                                                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  M  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Adenoma                              |    X                                                  X           X      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +  +     +     +     +  +  +  +  M        +  M  +   |             
      Leukemia Mononuclear                 |                X                                                         |             
      Pars Distalis, Adenoma               | X                       X                       X                    X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Leukemia Mononuclear                 |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 5| 7| 7| 7| 7| 5| 7| 4| 6| 4| 5| 7| 7| 7| 5| 5| 4| 7| 7| 6| 5|             
                             DAY ON TEST   | 4| 4| 2| 5| 5| 4| 4| 3| 3| 7| 3| 5| 5| 5| 7| 4| 4| 4| 7| 7| 5| 4| 1| 4| 7|             
                                           | 4| 4| 2| 8| 0| 5| 5| 9| 8| 6| 8| 8| 9| 7| 8| 5| 5| 5| 7| 6| 7| 4| 7| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    79VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Adenoma                      |                   X     X                    X  X              X         |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenoma             |                                                                      X   |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
      Bilateral, Adenoma                   |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma| X  X  X     X     X  X        X     X        X  X     X        X  X      |             
      Interstitial Cell, Adenoma           |                X                          X        X                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Leukemia Monocytic                   |                   X                                                      |             
      Leukemia Mononuclear                 |                                                                   X  X   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Axillary, Leukemia Mononuclear       |                                                                   X      |             
      Mediastinal, Leukemia Mononuclear    |                X  X                       X                       X  X   |             
      Pancreatic, Leukemia Mononuclear     |                                                                   X  X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Leukemia Mononuclear                 |                X  X                                               X  X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Leukemia Mononuclear                 |                X  X                                               X  X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Leukemia Mononuclear                 |                X  X                       X                       X  X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  M  +  +  +     +     +     +  +  M  +  +        +  +  +   |             
      Leukemia Mononuclear                 |                   X                                               X  X   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +  +  M  +  +     +     M     +  +  +  +  +        +  +  +   |             
      Fibroadenoma                         |                               X                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Carcinoma, Metastatic, Zymbal's Gland|                                                 X                        |             
      Keratoacanthoma                      |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 5| 7| 7| 7| 7| 5| 7| 4| 6| 4| 5| 7| 7| 7| 5| 5| 4| 7| 7| 6| 5|             
                             DAY ON TEST   | 4| 4| 2| 5| 5| 4| 4| 3| 3| 7| 3| 5| 5| 5| 7| 4| 4| 4| 7| 7| 5| 4| 1| 4| 7|             
                                           | 4| 4| 2| 8| 0| 5| 5| 9| 8| 6| 8| 8| 9| 7| 8| 5| 5| 5| 7| 6| 7| 4| 7| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    79VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |    X  X                                                                  |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Fibrous         |                                                                          |             
          Histiocytoma                     |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Osteosarcoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Granular Cell Tumor Benign           |                                                                          |             
      Leukemia Mononuclear                 |                   X                       X                              |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |             
      Carcinoma Adenosquamous              |                                                       X                  |             
      Leukemia Mononuclear                 |                X  X                       X                       X  X   |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                           +                              |             
                                            __________________________________________________________________________|             
   Eye                                     |                                     +                                    |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                     +                                    |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                 +  +                     |             
      Carcinoma                            |                                                 X  X                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Leukemia Mononuclear                 |                X  X                       X                       X      |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Leukemia Monocytic                   |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 5| 7| 7| 7| 7| 5| 7| 4| 6| 4| 5| 7| 7| 7| 5| 5| 4| 7| 7| 6| 5|             
                             DAY ON TEST   | 4| 4| 2| 5| 5| 4| 4| 3| 3| 7| 3| 5| 5| 5| 7| 4| 4| 4| 7| 7| 5| 4| 1| 4| 7|             
                                           | 4| 4| 2| 8| 0| 5| 5| 9| 8| 6| 8| 8| 9| 7| 8| 5| 5| 5| 7| 6| 7| 4| 7| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    79VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                X  X                       X                       X  X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 4| 7| 7| 6| 5| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 4| 4| 4| 3| 7| 5| 4| 4| 0| 7| 4| 4| 3| 7| 7| 4| 4| 3| 7| 7| 4| 4| 5| 3| 5|             
                                           | 4| 4| 4| 9| 6| 8| 5| 5| 5| 6| 6| 6| 8| 9| 6| 6| 6| 8| 6| 6| 5| 4| 8| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    79VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Lymphoid Tissue, Leukemia Mononuclear|                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Lymphoid Tissue, Leukemia Mononuclear|                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Hepatocellular Adenoma               |                   X                          X                           |             
      Leukemia Mononuclear                 | X                 X  X                                      X        X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +        +  +  +     +  +  M  +     +  +  +        +  +     +   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Leukemia Mononuclear                 |                   X                                                  X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Leukemia Mononuclear                 |                   X                                                      |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                                              X  X  X                     |             
      Bilateral, Pheochromocytoma Benign   |                                  X                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Adenoma                              |                                              X                           |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +        +  +  +     +  M  +  +     +  +  +        +  +     +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +        +  +  +     +  +  M  +     +  +  +        +  +     M   |             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               | X  X                 X                 X           X        X            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 4| 7| 7| 6| 5| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 4| 4| 4| 3| 7| 5| 4| 4| 0| 7| 4| 4| 3| 7| 7| 4| 4| 3| 7| 7| 4| 4| 5| 3| 5|             
                                           | 4| 4| 4| 9| 6| 8| 5| 5| 5| 6| 6| 6| 8| 9| 6| 6| 6| 8| 6| 6| 5| 4| 8| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    79VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Adenoma                      | X                    X           X  X                                    |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenoma             |                                                                          |             
      Follicular Cell, Carcinoma           |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +        M  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Adenoma                              | X                    X                                                   |             
      Carcinoma                            |                                                                          |             
      Bilateral, Adenoma                   |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Leukemia Mononuclear                 |                   X                                                      |             
      Bilateral, Interstitial Cell, Adenoma|       X  X        X  X        X  X  X        X  X  X        X  X         |             
      Interstitial Cell, Adenoma           | X  X                                                                 X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Leukemia Monocytic                   |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                   X  X                                                   |             
      Pancreatic, Leukemia Mononuclear     |                   X                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +        +  M  +     +  +  +  +     +  +  +        +  +     +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +        +  +  M     +  +  +  +     +  +  +        +  +     +   |             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  M        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Leukemia Mononuclear                 | X                 X  X                                      X        X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +        M  M  +     +  +  +  +     +  +  +        +  +     +   |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M        +  +  +     +  +  M  +     +  +  +        +  M     +   |             
      Fibroadenoma                         |    X                                         X                           |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |             
      Keratoacanthoma                      |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 4| 7| 7| 6| 5| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 4| 4| 4| 3| 7| 5| 4| 4| 0| 7| 4| 4| 3| 7| 7| 4| 4| 3| 7| 7| 4| 4| 5| 3| 5|             
                                           | 4| 4| 4| 9| 6| 8| 5| 5| 5| 6| 6| 6| 8| 9| 6| 6| 6| 8| 6| 6| 5| 4| 8| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    79VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Squamous Cell Papilloma              |                                  X                                       |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    | X                                                                        |             
      Subcutaneous Tissue, Fibrous         |                                                                          |             
          Histiocytoma                     |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Osteosarcoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Granular Cell Tumor Benign           |                                              X                           |             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Alveolar/Bronchiolar Adenoma         |                                              X                           |             
      Alveolar/Bronchiolar Carcinoma       |                         X                                                |             
      Carcinoma, Metastatic, Zymbal's Gland|                         X                                                |             
      Carcinoma Adenosquamous              |                                                                          |             
      Leukemia Mononuclear                 |                   X  X                                               X   |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +        +  +  +     +  +  M  +     +  +  +        +  +     +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                +         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                +         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                         +                                                |             
      Carcinoma                            |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Leukemia Mononuclear                 |                   X                                                  X   |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Leukemia Monocytic                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 4| 7| 7| 6| 5| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 4| 4| 4| 3| 7| 5| 4| 4| 0| 7| 4| 4| 3| 7| 7| 4| 4| 3| 7| 7| 4| 4| 5| 3| 5|             
                                           | 4| 4| 4| 9| 6| 8| 5| 5| 5| 6| 6| 6| 8| 9| 6| 6| 6| 8| 6| 6| 5| 4| 8| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    79VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 | X                 X  X                                      X        X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 5| 7| 7| 4| 6| 4| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 4| 3| 1| 5| 2| 4| 4| 5| 7| 7| 5| 3| 3| 7| 7| 4| 4| 9| 8| 4| 4| 4| 4| 2| 3|             
                                           | 4| 9| 6| 7| 0| 7| 4| 7| 0| 4| 0| 9| 8| 6| 6| 7| 7| 0| 1| 7| 7| 6| 4| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    79VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +     A  +  +  +  +        +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +     A  +  +  +  +        +  +  +  A  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +     A  +  +  +  +        +  +  +  +  A  +  +  +  +  A|             
      Lymphoid Tissue, Leukemia Mononuclear|                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +     A  M  +  +  +        +  +  +  A  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  +     A  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +  +     +  +  +  +  +        +  +  +  A  A  +  +  +  +  A|             
      Lymphoid Tissue, Leukemia Mononuclear|                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A     +  +  +     A  +  +  +  +        +  +  +  A  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                 X                        |             
      Leukemia Mononuclear                 |       X                    X                          X        X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +  +                       +|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  A  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  A  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                    X                          X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Pheochromocytoma Malignant           |       X                                                  X               |             
      Pheochromocytoma Benign              | X     X           X     X        X  X        X                    X      |             
      Bilateral, Pheochromocytoma Benign   |                               X                                X         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +     +  +  M  +  +        +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                         X                                                |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +     +  M  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |    X           X        X     X  X           X  X  X  X  X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 5| 7| 7| 4| 6| 4| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 4| 3| 1| 5| 2| 4| 4| 5| 7| 7| 5| 3| 3| 7| 7| 4| 4| 9| 8| 4| 4| 4| 4| 2| 3|             
                                           | 4| 9| 6| 7| 0| 7| 4| 7| 0| 4| 0| 9| 8| 6| 6| 7| 7| 0| 1| 7| 7| 6| 4| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    79VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Adenoma                      |                                  X              X                 X      |             
      C-Cell, Carcinoma                    | X                                                                        |             
      Follicular Cell, Adenoma             |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +     +  +  M     +  +  +  +  +        M  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                X                                                         |             
      Carcinoma                            |       X                                                                  |             
      Bilateral, Adenoma                   |                                                             X            |             
                                            __________________________________________________________________________|             
   Prostate                                | M  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma| X  X           X  X     X     X  X  X                 X     X  X  X  X  X|             
      Interstitial Cell, Adenoma           |       X     X              X                 X  X                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +     +  +     +  +        +  +  +  +  +  +  +  +  +  +|             
      Leukemia Monocytic                   |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |       X                    X                                             |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                    X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                    X                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  A  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                    X                          X        X         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  M  +  +  +|             
      Leukemia Mononuclear                 |       X                    X                          X                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  M     +  +  M     +  M  +  +  +        M     +  +  M  M  M  +  M  M|             
      Fibroadenoma                         |                               X                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +     +  M  +  +  +        M  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |             
      Keratoacanthoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 5| 7| 7| 4| 6| 4| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 4| 3| 1| 5| 2| 4| 4| 5| 7| 7| 5| 3| 3| 7| 7| 4| 4| 9| 8| 4| 4| 4| 4| 2| 3|             
                                           | 4| 9| 6| 7| 0| 7| 4| 7| 0| 4| 0| 9| 8| 6| 6| 7| 7| 0| 1| 7| 7| 6| 4| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    79VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                  X                             X         |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Fibrous         |                                                                          |             
          Histiocytoma                     |                                                                      X   |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                         X                                                |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Granular Cell Tumor Benign           |                                                                          |             
      Leukemia Mononuclear                 |       X                    X                          X                  |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                    X  X                  |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |             
      Carcinoma Adenosquamous              |                                                                          |             
      Leukemia Mononuclear                 |       X                    X                          X                  |             
      Osteosarcoma, Metastatic, Bone       |                         X                                                |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +     +                          +  +      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +     +                          +  +      |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                    X                                             |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Leukemia Monocytic                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 5| 7| 7| 4| 6| 4| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 4| 3| 1| 5| 2| 4| 4| 5| 7| 7| 5| 3| 3| 7| 7| 4| 4| 9| 8| 4| 4| 4| 4| 2| 3|             
                                           | 4| 9| 6| 7| 0| 7| 4| 7| 0| 4| 0| 9| 8| 6| 6| 7| 7| 0| 1| 7| 7| 6| 4| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    79VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |       X                    X                          X        X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4|                                                           |            |
                             DAY ON TEST   | 5| 5| 4| 4| 9|                                                           |            |
                                           | 0| 7| 7| 7| 9|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1|                                                           |     A      |
    VEHICLE                                | 6| 6| 6| 6| 6|                                                           |     L      |
    79VM                                   | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +  +  +                                                            |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +  +  +                                                            |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +  +  +                                                            |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +  +  +                                                            |  56        |
      Lymphoid Tissue, Leukemia Mononuclear|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +  +  +                                                            |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +  +  +                                                            |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +  +  +                                                            |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +  +  +                                                            |  55        |
      Lymphoid Tissue, Leukemia Mononuclear|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +  +  +                                                            |  53        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +  +  +                                                            |  60        |
      Hepatocellular Adenoma               |       X                                                                  |          4 |
      Leukemia Mononuclear                 |          X                                                               |         15 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   6        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +  +  +                                                            |  59        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +  +  +                                                            |  60        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +     +  +  +                                                            |  59        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +  +  +                                                            |  57        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +  +  +                                                            |  58        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +  +  +                                                            |  60        |
      Leukemia Mononuclear                 |          X                                                               |         10 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +  +  +                                                            |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +  +  +                                                            |  60        |
      Leukemia Mononuclear                 |          X                                                               |          7 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +     +  +  +                                                            |  60        |
      Leukemia Mononuclear                 |          X                                                               |          7 |
      Pheochromocytoma Malignant           |                                                                          |          3 |
      Pheochromocytoma Benign              |       X                                                                  |         15 |
      Bilateral, Pheochromocytoma Benign   | X                                                                        |          5 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +  +  +                                                            |  58        |
      Adenoma                              |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     +  +  +                                                            |  56        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  56                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4|                                                           |            |
                             DAY ON TEST   | 5| 5| 4| 4| 9|                                                           |            |
                                           | 0| 7| 7| 7| 9|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1|                                                           |     A      |
    VEHICLE                                | 6| 6| 6| 6| 6|                                                           |     L      |
    79VM                                   | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +  +                                                            |  56        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pars Distalis, Adenoma               | X     X  X                                                               |         23 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +  +  +                                                            |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      C-Cell, Adenoma                      |                                                                          |         12 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +     +  +  +                                                            |  60        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +     +  M  +                                                            |  56        |
      Adenoma                              |                                                                          |          3 |
      Carcinoma                            |                                                                          |          1 |
      Bilateral, Adenoma                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +     +  +  +                                                            |  59        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +     +  +  +                                                            |  60        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +     +  +  +                                                            |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Bilateral, Interstitial Cell, Adenoma|             X                                                            |         40 |
      Interstitial Cell, Adenoma           |                                                                          |         11 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +  +  +                                                            |  59        |
      Leukemia Monocytic                   |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +  +  +                                                            |  60        |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          9 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +  +  +                                                            |  58        |
      Leukemia Mononuclear                 |                                                                          |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +  +  +                                                            |  59        |
      Leukemia Mononuclear                 |                                                                          |          7 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +  +                                                            |  58        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  57                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4|                                                           |            |
                             DAY ON TEST   | 5| 5| 4| 4| 9|                                                           |            |
                                           | 0| 7| 7| 7| 9|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1|                                                           |     A      |
    VEHICLE                                | 6| 6| 6| 6| 6|                                                           |     L      |
    79VM                                   | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |          X                                                               |         15 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +  +  +                                                            |  55        |
      Leukemia Mononuclear                 |          X                                                               |          7 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     M  M  +                                                            |  42        |
      Fibroadenoma                         |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +  +                                                            |  58        |
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |          1 |
      Keratoacanthoma                      |                                                                          |          2 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |             X                                                            |          5 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
      Subcutaneous Tissue, Fibrous         |                                                                          |            |
          Histiocytoma                     |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma         |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +  +  +                                                            |  60        |
      Osteosarcoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +  +  +                                                            |  60        |
      Granular Cell Tumor Benign           |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          6 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +  +  +                                                            |  60        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          3 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |          1 |
      Carcinoma Adenosquamous              |                                                                          |          1 |
      Leukemia Mononuclear                 |          X                                                               |         12 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +  +  +                                                            |  59        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +  +  +                                                            |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  58                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4|                                                           |            |
                             DAY ON TEST   | 5| 5| 4| 4| 9|                                                           |            |
                                           | 0| 7| 7| 7| 9|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1|                                                           |     A      |
    VEHICLE                                | 6| 6| 6| 6| 6|                                                           |     L      |
    79VM                                   | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   6        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   6        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   3        |
      Carcinoma                            |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +  +  +                                                            |  60        |
      Leukemia Mononuclear                 |                                                                          |          8 |
      Renal Tubule, Adenoma                | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +  +  +                                                            |  60        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +     +  +  +                                                            |  60        |
      Leukemia Monocytic                   |                                                                          |          1 |
      Leukemia Mononuclear                 |          X                                                               |         15 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  59                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 4| 7| 5| 4| 4| 7| 7| 5| 2| 6| 5| 7| 3| 5| 4| 7| 6| 5| 5|             
                             DAY ON TEST   | 3| 3| 5| 7| 5| 4| 5| 3| 7| 5| 5| 4| 4| 7| 5| 6| 7| 4| 7| 3| 5| 4| 5| 7| 7|             
                                           | 9| 9| 3| 6| 7| 3| 8| 9| 6| 8| 8| 3| 3| 6| 3| 7| 6| 3| 0| 6| 8| 3| 9| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.025 G/                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    KG 79 LM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +        +     +           +  +     +  +     +  A  +     +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +        +     +           +  +     +  +     +  A  +     +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +        +     +           +  +     +  +     +  A  +     +  +      |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +        +     +           +  +     +  A     +  A  +     +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +        +     +           +  +     +  +     +  A  +     +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +        +     +           +  +     +  +     +  A  +     +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +        +     +           +  +     +  A     +  A  +     +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +        +     +           +  +     +  A     +  A  +     +  +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +        +     +           +  +     +  +     +  A  +     +  +      |             
      Hepatocellular Adenoma               |    X                                               X                     |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Leukemia Mononuclear                 |    X  X        X     X           X  X              X                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +        +     +           +  +     +  +     +  A  +     +  +      |             
      Leukemia Mononuclear                 |                                     X                                    |             
      Mesothelioma Malignant               |                                                                          |             
      Acinus, Adenoma                      |    X                                                                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +        +     +           +  +     +  +     +  A  +     +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +        +     +           +  +     +  +     +  A  +     +  +      |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +        +     +           +  +     +  +     +  A  +     +  +      |             
      Lipoma                               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
      Leukemia Mononuclear                 |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
      Leukemia Mononuclear                 |                                     X                                    |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |    X                                X                    X     X         |             
      Bilateral, Pheochromocytoma Benign   |                X                                   X                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +        +     +           +  +     +  +     +  A  +     +  +      |             
      Adenoma                              | X                    X                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 4| 7| 5| 4| 4| 7| 7| 5| 2| 6| 5| 7| 3| 5| 4| 7| 6| 5| 5|             
                             DAY ON TEST   | 3| 3| 5| 7| 5| 4| 5| 3| 7| 5| 5| 4| 4| 7| 5| 6| 7| 4| 7| 3| 5| 4| 5| 7| 7|             
                                           | 9| 9| 3| 6| 7| 3| 8| 9| 6| 8| 8| 3| 3| 6| 3| 7| 6| 3| 0| 6| 8| 3| 9| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.025 G/                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    KG 79 LM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +        +     +           +  +     +  M     +  M  +     +  +      |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
      Leukemia Mononuclear                 |                                     X                                    |             
      Pars Distalis, Adenoma               |                X     X                             X              X      |             
      Pars Distalis, Adenoma, Multiple     | X                                                                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +        +     +           +  +     +  +     +  A  +     +  +      |             
      C-Cell, Adenoma                      |       X                                      X     X                     |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +        +     +           +  +        +     +  +  +     +  +      |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +        +     +           +  M        +     +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +        +     +           +  +        +     +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
      Mesothelioma Malignant               |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma| X  X  X        X     X           X  X        X           X     X         |             
      Interstitial Cell, Adenoma           |                                                                   X      |             
      Tunic, Mesothelioma Malignant        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
      Mediastinal, Leukemia Mononuclear    |                X                    X                                    |             
      Pancreatic, Leukemia Mononuclear     |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M        +     +           +  +     +  +     +  +  +     +  +      |             
      Leukemia Mononuclear                 |                X                    X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +        +     +           +  +     +  M     +  +  +     +  +      |             
      Leukemia Mononuclear                 |                X                    X                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +        +     +           +  +     +  M     +  A  +     +  +      |             
      Leukemia Mononuclear                 |       X        X     X           X  X              X                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +        M     M           +  +     +  M     +  +  +     +  +      |             
      Leukemia Mononuclear                 |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M        +     +           +  M     +  M     M  M  +     M  +      |             
      Fibroadenoma                         |                      X           X                                       |             
      Fibroadenoma, Multiple               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 4| 7| 5| 4| 4| 7| 7| 5| 2| 6| 5| 7| 3| 5| 4| 7| 6| 5| 5|             
                             DAY ON TEST   | 3| 3| 5| 7| 5| 4| 5| 3| 7| 5| 5| 4| 4| 7| 5| 6| 7| 4| 7| 3| 5| 4| 5| 7| 7|             
                                           | 9| 9| 3| 6| 7| 3| 8| 9| 6| 8| 8| 3| 3| 6| 3| 7| 6| 3| 0| 6| 8| 3| 9| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.025 G/                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    KG 79 LM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
      Sebaceous Gland, Adenoma             |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
      Osteoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
      Neoplasm NOS                         |                X                                                         |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
      Alveolar/Bronchiolar Adenoma         |                X                                                         |             
      Leukemia Mononuclear                 |                                     X                                    |             
      Osteosarcoma, Metastatic             |       X                                                                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
      Schwannoma Benign                    |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                    +           +                 +                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                    +           +                 +              +      |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
      Leukemia Mononuclear                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +        +     +           +  +     +  +     +  A  +     +  +      |             
      Leukemia Mononuclear                 |                                     X                                    |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
      Leukemia Mononuclear                 |    X  X        X     X           X  X              X                     |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 0| 7| 7| 7| 6| 5| 7| 4| 7| 7| 6| 4| 7| 7| 6| 5| 7| 5| 5| 4| 4|             
                             DAY ON TEST   | 4| 4| 5| 3| 5| 4| 4| 1| 2| 7| 4| 5| 4| 0| 0| 5| 4| 3| 9| 7| 4| 8| 7| 5| 0|             
                                           | 3| 0| 7| 8| 4| 0| 4| 7| 8| 6| 0| 7| 0| 1| 3| 8| 3| 9| 7| 6| 4| 3| 6| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.025 G/                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    KG 79 LM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +  +  +  +  +  +     +     +  A  +     +  +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  M  +  +  +  +     +     +  A  A     +  +  +     +  +        A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | M  +     +  +  +  +  +  +     +     +  A  +     +  +  +     +  +        A|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +  +  +  +  +     +     +  A  +     +  +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +  A  +  +  +  +     +     +  A  +     +  +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  A  +  +  +  +     +     +  A  +     +  +  +     +  +        A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     M  A  +  +  +  +     +     +  A  +     +  +  +     +  +        A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  A  +  +  +  +     +     +  A  +     +  +  +     +  +        A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Hepatocellular Adenoma               |                                                                          |             
      Hepatocellular Adenoma, Multiple     | X                                                                        |             
      Leukemia Mononuclear                 |          X     X              X                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                +         |             
      Mesothelioma Malignant               |                                                                X         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  A  +  +  +  +     +     +  A  +     +  +  +     +  +        +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                X         |             
      Acinus, Adenoma                      |                                     X                       X            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Squamous Cell Carcinoma              |          X                                                               |             
      Squamous Cell Papilloma              |          X                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Lipoma                               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Malignant           |                                           X                              |             
      Pheochromocytoma Benign              | X  X     X                    X     X  X                                 |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  A  +  +  +  +     +     +  A  +     +  +  +     +  +        +|             
      Adenoma                              |                X                    X                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 0| 7| 7| 7| 6| 5| 7| 4| 7| 7| 6| 4| 7| 7| 6| 5| 7| 5| 5| 4| 4|             
                             DAY ON TEST   | 4| 4| 5| 3| 5| 4| 4| 1| 2| 7| 4| 5| 4| 0| 0| 5| 4| 3| 9| 7| 4| 8| 7| 5| 0|             
                                           | 3| 0| 7| 8| 4| 0| 4| 7| 8| 6| 0| 7| 0| 1| 3| 8| 3| 9| 7| 6| 4| 3| 6| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.025 G/                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    KG 79 LM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  M  +  +  +  M     +     +  +  +     +  +  +     +  +        M|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |                   X  X        X     X                 X     X            |             
      Pars Distalis, Adenoma, Multiple     |                                                 X                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  A  +  +  +  +     +     +  A  +     +  +  +     +  +        A|             
      C-Cell, Adenoma                      |    X                 X                                                   |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +  +  +  +  +  +     +     +  A  +     +  +  +     +  +        +|             
      Mesothelioma Malignant               |                                                                X         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +     M  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Mesothelioma Malignant               |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma| X  X     X     X  X  X  X     X     X  X  X     X  X        X  X         |             
      Interstitial Cell, Adenoma           |                                                                          |             
      Tunic, Mesothelioma Malignant        |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +  +  +  +     +     +  A  +     +  +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     M  +        +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  +  +  +  +     +     +  A  +     +  +  +     +  M        M|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +  +  +  +     +     +  A  +     +  +  +     +  +        +|             
      Leukemia Mononuclear                 |          X     X              X                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +     +  +  +  M  +  +     M     +  +  +     +  +  +     +  +        +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M     +  M  M  +  +  +     M     +  +  +     +  +  +     +  M        +|             
      Fibroadenoma                         |                   X  X                             X                     |             
      Fibroadenoma, Multiple               |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 0| 7| 7| 7| 6| 5| 7| 4| 7| 7| 6| 4| 7| 7| 6| 5| 7| 5| 5| 4| 4|             
                             DAY ON TEST   | 4| 4| 5| 3| 5| 4| 4| 1| 2| 7| 4| 5| 4| 0| 0| 5| 4| 3| 9| 7| 4| 8| 7| 5| 0|             
                                           | 3| 0| 7| 8| 4| 0| 4| 7| 8| 6| 0| 7| 0| 1| 3| 8| 3| 9| 7| 6| 4| 3| 6| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.025 G/                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    KG 79 LM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Sebaceous Gland, Adenoma             |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Osteoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Neoplasm NOS                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Osteosarcoma, Metastatic             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Schwannoma Benign                    |                         X                                                |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        A|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +           +  +           +                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +           +  +                                                      |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +  +  +  +     +     +  A  +     +  +  +     +  +        A|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Leukemia Mononuclear                 |          X     X              X                                          |             
      Mesothelioma Malignant               |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 7| 5| 4| 3| 7| 7| 7| 7| 5| 7| 4| 7| 5| 5| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 1| 3| 7| 0| 4| 3| 5| 8| 0| 4| 3| 3| 3| 8| 4| 5| 4| 6| 2| 4| 4| 3| 3| 3|             
                                           | 8| 8| 4| 6| 0| 3| 8| 3| 4| 6| 3| 9| 8| 8| 2| 3| 7| 3| 7| 6| 3| 3| 2| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.025 G/                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    KG 79 LM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  M  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Leukemia Mononuclear                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +                       +         |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  M  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
      Acinus, Adenoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                     X        X                 X         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Lipoma                               |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Adenoma                              |    X                                                                     |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              | X                                   X                       X            |             
      Bilateral, Pheochromocytoma Benign   |                                  X     X     X     X           X         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +  +  +  +|             
      Adenoma                              |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 7| 5| 4| 3| 7| 7| 7| 7| 5| 7| 4| 7| 5| 5| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 1| 3| 7| 0| 4| 3| 5| 8| 0| 4| 3| 3| 3| 8| 4| 5| 4| 6| 2| 4| 4| 3| 3| 3|             
                                           | 8| 8| 4| 6| 0| 3| 8| 3| 4| 6| 3| 9| 8| 8| 2| 3| 7| 3| 7| 6| 3| 3| 2| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.025 G/                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    KG 79 LM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Adenoma                              |                               X                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               | X           X                    X  X     X              X     X         |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                     X     X  X                           |             
      Follicular Cell, Adenoma             |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                             X            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +     +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                         X|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                             X            |             
      Bilateral, Interstitial Cell, Adenoma| X  X  X        X  X  X        X  X     X           X  X  X  X        X   |             
      Interstitial Cell, Adenoma           |                         X           X     X                    X  X     X|             
      Tunic, Mesothelioma Malignant        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +  +  +  +  +  M  +  +  M  +  +  +     +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +  M  +  +  +  +  +  +     +  A  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +     +  +  +  +  +  +  +  +  M  +  +  +     +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +     M  +  M  M  M  +  +  +  M  +  +  M     +     +  M  +  +  M  +|             
      Fibroadenoma                         |                                                                          |             
      Fibroadenoma, Multiple               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 7| 5| 4| 3| 7| 7| 7| 7| 5| 7| 4| 7| 5| 5| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 1| 3| 7| 0| 4| 3| 5| 8| 0| 4| 3| 3| 3| 8| 4| 5| 4| 6| 2| 4| 4| 3| 3| 3|             
                                           | 8| 8| 4| 6| 0| 3| 8| 3| 4| 6| 3| 9| 8| 8| 2| 3| 7| 3| 7| 6| 3| 3| 2| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.025 G/                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    KG 79 LM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Sebaceous Gland, Adenoma             |                                                                      X   |             
      Subcutaneous Tissue, Fibroma         |                      X                                                   |             
      Subcutaneous Tissue, Fibrosarcoma    |                X           X                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Osteoma                              |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  M  +  +  +  +  +|             
      Neoplasm NOS                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                X         |             
      Leukemia Mononuclear                 |                                                                          |             
      Osteosarcoma, Metastatic             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Schwannoma Benign                    |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                     +     +  +                           |             
                                            __________________________________________________________________________|             
   Eye                                     |                +  +     +                                +               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +                                                      |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                         +                    +                           |             
      Carcinoma                            |                         X                    X                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
      Mesothelioma Malignant               |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 4|                                                           |            |
                             DAY ON TEST   | 4| 5| 1| 0| 7|                                                           |            |
                                           | 3| 0| 1| 9| 4|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3|                                                           |     A      |
    0.025 G/                               | 2| 2| 2| 2| 2|                                                           |     L      |
    KG 79 LM                               | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  A  +  +  +                                                            |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +                                                            |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  A  +  +  +                                                            |  54        |
      Mesothelioma Malignant               | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +  +                                                            |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  A  +  +  +                                                            |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  +                                                            |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +                                                            |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +                                                            |  53        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |  59        |
      Hepatocellular Adenoma               |                                                                          |          2 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Leukemia Mononuclear                 |             X                                                            |         12 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |  56        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
      Acinus, Adenoma                      |       X                                                                  |          4 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |  59        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +                                                            |  59        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |  59        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |  59        |
      Lipoma                               |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +                                                            |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +                                                            |  60        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +                                                            |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  69                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 4|                                                           |            |
                             DAY ON TEST   | 4| 5| 1| 0| 7|                                                           |            |
                                           | 3| 0| 1| 9| 4|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3|                                                           |     A      |
    0.025 G/                               | 2| 2| 2| 2| 2|                                                           |     L      |
    KG 79 LM                               | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                          |         13 |
      Bilateral, Pheochromocytoma Benign   | X                                                                        |          8 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |  56        |
      Adenoma                              |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +                                                            |  54        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |  59        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pars Distalis, Adenoma               |       X                                                                  |         18 |
      Pars Distalis, Adenoma, Multiple     |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |  55        |
      C-Cell, Adenoma                      |          X                                                               |          9 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +                                                            |  58        |
      Mesothelioma Malignant               | X                                                                        |          3 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +                                                            |  59        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +                                                            |  57        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +                                                            |  59        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +                                                            |  60        |
      Mesothelioma Malignant               |                                                                          |          1 |
      Bilateral, Interstitial Cell, Adenoma| X     X                                                                  |         41 |
      Interstitial Cell, Adenoma           |    X        X                                                            |          9 |
      Tunic, Mesothelioma Malignant        | X                                                                        |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |  58        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +                                                            |  59        |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          2 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |  56        |
      Leukemia Mononuclear                 |             X                                                            |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |  54        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  70                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 4|                                                           |            |
                             DAY ON TEST   | 4| 5| 1| 0| 7|                                                           |            |
                                           | 3| 0| 1| 9| 4|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3|                                                           |     A      |
    0.025 G/                               | 2| 2| 2| 2| 2|                                                           |     L      |
    KG 79 LM                               | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |             X                                                            |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |  56        |
      Leukemia Mononuclear                 |             X                                                            |         11 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +                                                            |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +                                                            |  36        |
      Fibroadenoma                         |                                                                          |          5 |
      Fibroadenoma, Multiple               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |  60        |
      Sebaceous Gland, Adenoma             |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         | X                                                                        |          2 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |  60        |
      Osteoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |  59        |
      Neoplasm NOS                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |  60        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Leukemia Mononuclear                 |             X                                                            |          2 |
      Osteosarcoma, Metastatic             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |  60        |
      Schwannoma Benign                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |  58        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                                            |  13        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +                                                            |  10        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
      Carcinoma                            |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  71                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 4|                                                           |            |
                             DAY ON TEST   | 4| 5| 1| 0| 7|                                                           |            |
                                           | 3| 0| 1| 9| 4|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3|                                                           |     A      |
    0.025 G/                               | 2| 2| 2| 2| 2|                                                           |     L      |
    KG 79 LM                               | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  A  +  +  +                                                            |  55        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +                                                            |  60        |
      Leukemia Mononuclear                 |             X                                                            |         12 |
      Mesothelioma Malignant               | X                                                                        |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  72                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 3| 7| 6| 5| 4| 2| 7| 4| 7| 4| 7| 7| 7| 5| 5| 3| 7| 6| 5| 3| 2|             
                             DAY ON TEST   | 3| 3| 3| 7| 8| 3| 2| 7| 5| 5| 3| 5| 3| 5| 3| 3| 3| 7| 7| 3| 3| 9| 7| 1| 6|             
                                           | 8| 9| 9| 6| 3| 4| 0| 6| 7| 4| 8| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 0| 6| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.05 G/K                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    G 79 HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  A     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  A     +  +  +        +  +     +     +  +  +        +  +  +     +  M|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  A     +  +  +        +  +     +     +  +  +        A  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A     +  +  +        +  +     +     +  +  M        A  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A     +  +  +        +  +     +     +  +  +        A  +  +     +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A     +  +  +        +  +     +     +  +  +        A  +  +     A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               | X                                   X     X     X                        |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +  +                                                         |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +        +  +     +     +  +  M        +  +  +     +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Palate, Squamous Cell Papilloma      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Basosquamous Tumor Benign            |                                                             X            |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  A     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Malignant           |                   X                                                      |             
      Pheochromocytoma Benign              | X                                         X  X              X            |             
      Bilateral, Pheochromocytoma Benign   |                X              X     X           X                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +        +  +     +     +  +  M        +  +  +     +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +     +  +  M        M  +     M     +  +  +        +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 3| 7| 6| 5| 4| 2| 7| 4| 7| 4| 7| 7| 7| 5| 5| 3| 7| 6| 5| 3| 2|             
                             DAY ON TEST   | 3| 3| 3| 7| 8| 3| 2| 7| 5| 5| 3| 5| 3| 5| 3| 3| 3| 7| 7| 3| 3| 9| 7| 1| 6|             
                                           | 8| 9| 9| 6| 3| 4| 0| 6| 7| 4| 8| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 0| 6| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.05 G/K                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    G 79 HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  M|             
      Pars Distalis, Adenoma               | X  X  X                                         X           X  X         |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  A     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      C-Cell, Adenoma                      |                X                                               X         |             
      C-Cell, Carcinoma                    |                                                                X         |             
      Follicular Cell, Carcinoma           |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                X         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma| X     X        X  X           X     X     X  X  X           X  X         |             
      Interstitial Cell, Adenoma           |    X                                                                     |             
      Tunic, Mesothelioma Malignant        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +  +        +  +     +     +  +  +        M  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  +  +        +  +     +     +  +  +        +  M  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +     +  +  M        +  +     +     +  +  +        M  +  +     +  +|             
      Fibroadenoma                         |                                                 X                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 3| 7| 6| 5| 4| 2| 7| 4| 7| 4| 7| 7| 7| 5| 5| 3| 7| 6| 5| 3| 2|             
                             DAY ON TEST   | 3| 3| 3| 7| 8| 3| 2| 7| 5| 5| 3| 5| 3| 5| 3| 3| 3| 7| 7| 3| 3| 9| 7| 1| 6|             
                                           | 8| 9| 9| 6| 3| 4| 0| 6| 7| 4| 8| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 0| 6| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.05 G/K                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    G 79 HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Keratoacanthoma                      |                                                             X            |             
      Squamous Cell Papilloma              |                                                             X            |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Alveolar/Bronchiolar Adenoma         |                                              X                           |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Fibrosarcoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +              +        +   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                              +              +        +   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  A     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 5| 4| 6| 6| 5| 5| 4| 7| 7| 7| 5| 2| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 9| 1| 5| 7| 0| 7| 1| 4| 1| 5| 3| 3| 2| 8| 6| 3| 1| 1| 0| 1| 3| 3| 3| 5| 3|             
                                           | 0| 7| 7| 6| 1| 5| 2| 0| 5| 7| 8| 8| 2| 6| 1| 8| 1| 4| 9| 8| 8| 9| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.05 G/K                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    G 79 HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  M     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +        +  +  +  +  A     +  +  +  +  +  +  A  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A        A  +  +  +  A     +  +  +  +  +  +  A  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +        +  +  +  +  A     +  +  +  +  +  +  A  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  A        A  +  +  +  A     +  +  +  +  +  +  A  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A        A  +  +  +  M     +  +  +  +  +  +  A  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +        +  +  +  +  A     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Mesothelioma Malignant               |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A        A  +  +  +  A     +  +  M  +  +  +  A  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hepatocellular Carcinoma             |                   X                                                      |             
      Hepatocellular Adenoma               |                                                       X                  |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Leukemia Mononuclear                 | X              X                    X           X     X        X  X      |             
                                            __________________________________________________________________________|             
   Mesentery                               | +              +                                                         |             
      Mesothelioma Malignant               |                X                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Mesothelioma Malignant               |                X                                                         |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Palate, Squamous Cell Papilloma      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +        +  +  +  +  A     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Basosquamous Tumor Benign            |                                                                          |             
      Squamous Cell Papilloma              |                                                                   X      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  M        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 | X                                               X     X        X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                X         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                X         |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                               X                 X           X            |             
      Bilateral, Pheochromocytoma Benign   |                                  X                    X           X      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 5| 4| 6| 6| 5| 5| 4| 7| 7| 7| 5| 2| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 9| 1| 5| 7| 0| 7| 1| 4| 1| 5| 3| 3| 2| 8| 6| 3| 1| 1| 0| 1| 3| 3| 3| 5| 3|             
                                           | 0| 7| 7| 6| 1| 5| 2| 0| 5| 7| 8| 8| 2| 6| 1| 8| 1| 4| 9| 8| 8| 9| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.05 G/K                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    G 79 HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +        +  M  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Pars Distalis, Adenoma               |                         X                          X                     |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +        +  +  A  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      C-Cell, Adenoma                      |                                     X        X                           |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Mesothelioma Malignant               |                X                                         X               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +        +  +  +  M  +     +  +  +  M  +  +  +  +  +  +  +  +  +     +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                 X                        |             
      Mesothelioma Malignant               |                X                                                         |             
      Bilateral, Interstitial Cell, Adenoma| X  X              X  X  X     X  X  X  X     X  X     X  X  X  X  X     X|             
      Interstitial Cell, Adenoma           |                X                                                         |             
      Tunic, Mesothelioma Malignant        |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Mediastinal, Leukemia Mononuclear    | X                                               X     X                  |             
      Pancreatic, Leukemia Mononuclear     |                                                 X     X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M        +  +  +  M  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 | X                                               X     X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +        +  +  +  +  A     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                 X     X                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +        +  +  +  +  +     +  +  +  +  +  +  A  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 | X              X                    X                 X        X  X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +        M  M  +  +  +     +  +  +  +  M  M  M  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +        +  M  M  M  +     M  M  M  +  +  M  +  +  +  M  M  +  +     M|             
      Fibroadenoma                         |                                                                X         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +        +  +  +  M  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 5| 4| 6| 6| 5| 5| 4| 7| 7| 7| 5| 2| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 9| 1| 5| 7| 0| 7| 1| 4| 1| 5| 3| 3| 2| 8| 6| 3| 1| 1| 0| 1| 3| 3| 3| 5| 3|             
                                           | 0| 7| 7| 6| 1| 5| 2| 0| 5| 7| 8| 8| 2| 6| 1| 8| 1| 4| 9| 8| 8| 9| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.05 G/K                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    G 79 HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Keratoacanthoma                      |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                X                                               X         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Alveolar/Bronchiolar Adenoma         |                                  X                                       |             
      Leukemia Mononuclear                 | X              X                                X     X        X  X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +        M  M  M  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Fibrosarcoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                             +           +                 +            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                             +                             +            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                  +                                       |             
      Carcinoma                            |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 | X                                               X     X                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +        +  +  +  +  A     +  +  +  +  +  +  A  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 | X                                                                        |             
      Mesothelioma Malignant               |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 | X              X                    X           X     X        X  X      |             
      Mesothelioma Malignant               |                X                                         X              X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 4| 4| 7| 7| 7| 6| 4| 7| 7| 6| 2| 2| 7| 6| 5| 2| 2| 4| 4| 7| 6| 0|             
                             DAY ON TEST   | 3| 3| 7| 6| 0| 3| 3| 0| 6| 5| 3| 3| 1| 6| 4| 4| 1| 7| 2| 5| 5| 5| 3| 4| 6|             
                                           | 9| 8| 6| 5| 5| 9| 9| 8| 2| 8| 9| 9| 2| 4| 8| 0| 2| 6| 9| 1| 8| 8| 9| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.05 G/K                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    G 79 HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  M        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +  +  +  +  +     +  +  +  +  A  +  +     +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                      X                                                   |             
      Hepatocellular Adenoma, Multiple     |                                  X                                       |             
      Leukemia Mononuclear                 | X                 X              X  X                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                       +                  |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                   +      |             
      Palate, Squamous Cell Papilloma      |                                                                   X      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Basosquamous Tumor Benign            |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Leukemia Mononuclear                 |                   X                 X                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Leukemia Mononuclear                 |                   X                 X                                    |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +  +  +  +  +  +     +  +  +  +  +  +  M     +  +        +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                      X                                                   |             
      Bilateral, Pheochromocytoma Benign   |    X                    X                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Adenoma                              | X                                                                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  +  +  M  +     +  +  +  M  M  +  +     M  M        +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 4| 4| 7| 7| 7| 6| 4| 7| 7| 6| 2| 2| 7| 6| 5| 2| 2| 4| 4| 7| 6| 0|             
                             DAY ON TEST   | 3| 3| 7| 6| 0| 3| 3| 0| 6| 5| 3| 3| 1| 6| 4| 4| 1| 7| 2| 5| 5| 5| 3| 4| 6|             
                                           | 9| 8| 6| 5| 5| 9| 9| 8| 2| 8| 9| 9| 2| 4| 8| 0| 2| 6| 9| 1| 8| 8| 9| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.05 G/K                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    G 79 HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  +  +  M     +  +  +  M  +  +  +     +  +        +  +  +|             
      Pars Distalis, Adenoma               |    X     X           X                          X                    X   |             
      Pars Distalis, Adenoma, Multiple     |                                              X                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      C-Cell, Adenoma                      |                         X           X           X                    X   |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +     M  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  M|             
      Adenoma                              |                X        X        X                                       |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma| X  X        X  X  X  X  X     X  X  X        X  X                 X  X   |             
      Interstitial Cell, Adenoma           |                                                                          |             
      Tunic, Mesothelioma Malignant        |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Mediastinal, Leukemia Mononuclear    |                                     X                                    |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  M        +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Leukemia Mononuclear                 | X                 X              X  X                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  M  +  +  +  +     +  +  M  +  +  +  +     +  +        +  +  +|             
      Leukemia Mononuclear                 |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +  +  +  +  M     +  +  M  +  +  +  M     +  +        M  M  M|             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 4| 4| 7| 7| 7| 6| 4| 7| 7| 6| 2| 2| 7| 6| 5| 2| 2| 4| 4| 7| 6| 0|             
                             DAY ON TEST   | 3| 3| 7| 6| 0| 3| 3| 0| 6| 5| 3| 3| 1| 6| 4| 4| 1| 7| 2| 5| 5| 5| 3| 4| 6|             
                                           | 9| 8| 6| 5| 5| 9| 9| 8| 2| 8| 9| 9| 2| 4| 8| 0| 2| 6| 9| 1| 8| 8| 9| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.05 G/K                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    G 79 HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Keratoacanthoma                      |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Alveolar/Bronchiolar Adenoma         |    X                          X              X                           |             
      Leukemia Mononuclear                 |                   X              X  X                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  M|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |    +                                                                     |             
      Fibrosarcoma                         |    X                                                                     |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +                    +                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                  +                                       |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Leukemia Mononuclear                 |                   X                 X                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +  +  +  M     +  +  +  +  +  +  +     +  +        +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Leukemia Mononuclear                 | X                 X              X  X                                    |             
      Mesothelioma Malignant               |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 5| 5| 4|                                                           |            |
                             DAY ON TEST   | 3| 5| 7| 7| 6|                                                           |            |
                                           | 9| 8| 6| 6| 7|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4|                                                           |     A      |
    0.05 G/K                               | 8| 8| 8| 8| 8|                                                           |     L      |
    G 79 HM                                | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +           +                                                            |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +           +                                                            |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +           +                                                            |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +           +                                                            |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +           +                                                            |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +           +                                                            |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +           +                                                            |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +           +                                                            |  57        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +           +                                                            |  51        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +           +                                                            |  60        |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |          6 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |         11 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +           +                                                            |  59        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Palate, Squamous Cell Papilloma      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | M           +                                                            |  59        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +           +                                                            |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +           +                                                            |  59        |
      Basosquamous Tumor Benign            |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +           +                                                            |  58        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +           +                                                            |  60        |
      Leukemia Mononuclear                 |                                                                          |          6 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +           +                                                            |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +           +                                                            |  60        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +           +                                                            |  59        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  82                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 5| 5| 4|                                                           |            |
                             DAY ON TEST   | 3| 5| 7| 7| 6|                                                           |            |
                                           | 9| 8| 6| 6| 7|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4|                                                           |     A      |
    0.05 G/K                               | 8| 8| 8| 8| 8|                                                           |     L      |
    G 79 HM                                | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pheochromocytoma Benign              |                                                                          |          8 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          9 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +           +                                                            |  59        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +           +                                                            |  51        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +           +                                                            |  56        |
      Pars Distalis, Adenoma               |                                                                          |         13 |
      Pars Distalis, Adenoma, Multiple     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +           +                                                            |  58        |
      C-Cell, Adenoma                      | X                                                                        |          9 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +           +                                                            |  60        |
      Mesothelioma Malignant               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +           +                                                            |  56        |
      Adenoma                              |                                                                          |          3 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +           +                                                            |  60        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +           +                                                            |  60        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +           +                                                            |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
      Bilateral, Interstitial Cell, Adenoma| X           X                                                            |         44 |
      Interstitial Cell, Adenoma           |                                                                          |          2 |
      Tunic, Mesothelioma Malignant        |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +           +                                                            |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +           +                                                            |  60        |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          4 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M           +                                                            |  56        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +           +                                                            |  58        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  83                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 5| 5| 4|                                                           |            |
                             DAY ON TEST   | 3| 5| 7| 7| 6|                                                           |            |
                                           | 9| 8| 6| 6| 7|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4|                                                           |     A      |
    0.05 G/K                               | 8| 8| 8| 8| 8|                                                           |     L      |
    G 79 HM                                | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +           +                                                            |  59        |
      Leukemia Mononuclear                 |                                                                          |         10 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +           +                                                            |  52        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +           +                                                            |  41        |
      Fibroadenoma                         |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +           +                                                            |  59        |
      Keratoacanthoma                      |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +           +                                                            |  60        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +           +                                                            |  60        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +           +                                                            |  60        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          5 |
      Leukemia Mononuclear                 |                                                                          |          9 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +           +                                                            |  56        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +           +                                                            |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      Fibrosarcoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   9        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   7        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +           +                                                            |  60        |
      Leukemia Mononuclear                 |                                                                          |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  84                                                               
NTP Experiment-Test: 05047-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 08:50:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 5| 5| 4|                                                           |            |
                             DAY ON TEST   | 3| 5| 7| 7| 6|                                                           |            |
                                           | 9| 8| 6| 6| 7|                                                           |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0|                                                           |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4|                                                           |     A      |
    0.05 G/K                               | 8| 8| 8| 8| 8|                                                           |     L      |
    G 79 HM                                | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +           +                                                            |  56        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +           +                                                            |  60        |
      Leukemia Mononuclear                 |                                                                          |         11 |
      Mesothelioma Malignant               |                                                                          |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  85                                                               
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