Share This:
https://ntp.niehs.nih.gov/go/1305

TR 399 Rat Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                       TITANOCENE DICHLORIDE


NTP Experiment-Test: 05047-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/06/94
Route: GAVAGE                                                                                                     Time: 21:43:31




       Facility:  TSI Mason Research

       Chemical CAS #:  1271-19-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05047-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 09/06/94  
Route: GAVAGE                                                                                                     Time: 21:43:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      0.025 G/     0.05 G/K                                               
                                                   79 VF        KG 79 LF     G 79 HF                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          80           80           80                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          19           25           21                                                  
    Dead                                               4            5            7                                                  
    Accident                                                        1                                                               
    Moribund Sacrifice                                                           1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           30           31                                                  
    Moribund                                           1                                                                            
  Aborted                                             10            9           10                                                  
  Animals Examined Microscopically                    60           61           60                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (59)         (57)         (56)                                                
      Leiomyosarcoma                                                             1 (2%)                                             
   Liver                                              (60)         (61)         (60)                                                
      Hepatocellular Adenoma                                                     2 (3%)                                             
      Neoplastic Nodule                                             1 (2%)                                                          
   Mesentery                                          (3)          (9)          (10)                                                
   Pancreas                                           (60)         (61)         (59)                                                
      Acinus, Adenoma                                  1 (2%)       1 (2%)       1 (2%)                                             
   Pharynx                                                                      (1)                                                 
      Palate, Squamous Cell Papilloma                                            1 (100%)                                           
   Salivary Glands                                    (60)         (61)         (60)                                                
   Stomach, Forestomach                               (60)         (60)         (60)                                                
      Squamous Cell Papilloma                                       1 (2%)       2 (3%)                                             
   Stomach, Glandular                                 (60)         (60)         (60)                                                
   Tooth                                              (1)                                                                           
      Pulp, Fibroma                                    1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (61)         (60)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05047-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 09/06/94  
Route: GAVAGE                                                                                                     Time: 21:43:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      0.025 G/     0.05 G/K                                               
                                                   79 VF        KG 79 LF     G 79 HF                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (59)         (61)         (60)                                                
   Adrenal Gland, Medulla                             (58)         (60)         (59)                                                
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Benign                          6 (10%)      6 (10%)      4 (7%)                                             
      Bilateral, Pheochromocytoma Benign                            1 (2%)       2 (3%)                                             
   Islets, Pancreatic                                 (59)         (61)         (59)                                                
      Adenoma                                          2 (3%)                                                                       
      Adenoma, Multiple                                             1 (2%)                                                          
   Pituitary Gland                                    (59)         (59)         (60)                                                
      Pars Distalis, Adenoma                          26 (44%)     22 (37%)     16 (27%)                                            
      Pars Distalis, Adenoma, Multiple                 3 (5%)       1 (2%)                                                          
   Thyroid Gland                                      (60)         (57)         (59)                                                
      Bilateral, C-Cell, Adenoma                                    1 (2%)                                                          
      Bilateral, C-Cell, Carcinoma                                  2 (4%)                                                          
      C-Cell, Adenoma                                  9 (15%)      7 (12%)      7 (12%)                                            
      C-Cell, Carcinoma                                1 (2%)       1 (2%)                                                          
      Follicular Cell, Adenoma, Multiple                                         1 (2%)                                             
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                   (1)                                                 
      Sarcoma                                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (56)         (55)         (56)                                                
      Adenoma                                          9 (16%)      8 (15%)      2 (4%)                                             
      Carcinoma                                        1 (2%)       1 (2%)                                                          
      Bilateral, Adenoma                               3 (5%)                                                                       
   Ovary                                              (58)         (61)         (60)                                                
   Uterus                                             (60)         (61)         (60)                                                
      Adenoma                                          1 (2%)                                                                       
      Polyp Stromal                                   11 (18%)     10 (16%)     14 (23%)                                            
      Bilateral, Polyp Stromal                                                   2 (3%)                                             
      Cervix, Sarcoma                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (2)                                                                           
   Bone Marrow                                        (59)         (61)         (59)                                                
   Lymph Node                                         (60)         (61)         (60)                                                
   Lymph Node, Mandibular                             (56)         (59)         (60)                                                
                                                             Page   3                                                               
NTP Experiment-Test: 05047-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 09/06/94  
Route: GAVAGE                                                                                                     Time: 21:43:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      0.025 G/     0.05 G/K                                               
                                                   79 VF        KG 79 LF     G 79 HF                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Lymph Node, Mesenteric                             (60)         (61)         (60)                                                
   Spleen                                             (60)         (60)         (60)                                                
      Sarcoma                                                       1 (2%)       1 (2%)                                             
   Thymus                                             (55)         (56)         (58)                                                
      Epithelial Cell, Thymoma Benign                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (56)         (56)         (49)                                                
      Adenocarcinoma                                   2 (4%)       1 (2%)                                                          
      Adenocarcinoma, Multiple                         1 (2%)                                                                       
      Adenoma                                          1 (2%)       1 (2%)                                                          
      Fibroadenoma                                    17 (30%)     17 (30%)     15 (31%)                                            
      Fibroadenoma, Multiple                           9 (16%)      7 (13%)      3 (6%)                                             
   Skin                                               (60)         (61)         (58)                                                
      Basal Cell Carcinoma                             1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                                  1 (2%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                                  1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (61)         (60)                                                
      Astrocytoma Malignant                            1 (2%)                                                                       
      Granular Cell Tumor Benign                       1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (61)         (60)                                                
      Alveolar/Bronchiolar Adenoma                     1 (2%)       1 (2%)       1 (2%)                                             
      Alveolar/Bronchiolar Adenoma, Multiple                                     1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)       1 (2%)                                                          
      Carcinoma, Metastatic, Zymbal's Gland                                      1 (2%)                                             
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (2%)                                                                       
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                1 (2%)                                                                       
      Pleura, Alveolar/Bronchiolar Carcinoma,                                                                                       
                                                             Page   4                                                               
NTP Experiment-Test: 05047-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 09/06/94  
Route: GAVAGE                                                                                                     Time: 21:43:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      0.025 G/     0.05 G/K                                               
                                                   79 VF        KG 79 LF     G 79 HF                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
          Metastatic                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (5)          (11)         (18)                                                
   Zymbal's Gland                                                               (1)                                                 
      Carcinoma                                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (61)         (60)                                                
      Renal Tubule, Adenoma                                         1 (2%)                                                          
   Urinary Bladder                                    (60)         (58)         (60)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(61)        *(60)                                                
      Leukemia Mononuclear                            21 (35%)     20 (33%)     15 (25%)                                            
      Lymphoma Malignant Lymphocytic                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05047-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 09/06/94  
Route: GAVAGE                                                                                                     Time: 21:43:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      0.025 G/     0.05 G/K                                               
                                                   79 VF        KG 79 LF     G 79 HF                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            55          53          46                                                   
     Total Primary Neoplasms                          135         115          96                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 46          50          40                                                   
     Total Benign Neoplasms                           102          88          75                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              29          25          18                                                   
     Total Malignant Neoplasms                         33          27          21                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           1           1                                                   
     Total Metastatic Neoplasm                          5           1           1                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05047-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 09/06/94  
Route: GAVAGE                                                                                                     Time: 21:43:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0.025 G/     0.05 G/K                                               
                                                   79VM         KG 79 LM     G 79 HM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          80           80           80                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Dead                                              11           15           17                                                  
    Moribund                                           8           14           17                                                  
    Accident                                                        1            2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                41           30           24                                                  
  Aborted                                             10           10           10                                                  
  Animals Examined Microscopically                    60           60           60                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (56)         (54)         (57)                                                
   Intestine Small, Ileum                             (55)         (52)         (57)                                                
   Liver                                              (60)         (59)         (60)                                                
      Hepatocellular Carcinoma                                                   1 (2%)                                             
      Hepatocellular Adenoma                           4 (7%)       2 (3%)       6 (10%)                                            
      Hepatocellular Adenoma, Multiple                              1 (2%)       1 (2%)                                             
   Mesentery                                          (6)          (4)          (5)                                                 
   Pancreas                                           (59)         (56)         (59)                                                
      Acinus, Adenoma                                               4 (7%)                                                          
   Pharynx                                                                      (1)                                                 
      Palate, Squamous Cell Papilloma                                            1 (100%)                                           
   Stomach, Forestomach                               (57)         (59)         (59)                                                
      Basosquamous Tumor Benign                                                  1 (2%)                                             
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Squamous Cell Papilloma                                       4 (7%)       1 (2%)                                             
   Stomach, Glandular                                 (58)         (59)         (58)                                                
      Lipoma                                                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05047-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 09/06/94  
Route: GAVAGE                                                                                                     Time: 21:43:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0.025 G/     0.05 G/K                                               
                                                   79VM         KG 79 LM     G 79 HM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (60)         (60)                                                
      Adenoma                                                       1 (2%)                                                          
   Adrenal Gland, Medulla                             (60)         (60)         (59)                                                
      Pheochromocytoma Malignant                       3 (5%)       1 (2%)       1 (2%)                                             
      Pheochromocytoma Benign                         15 (25%)     13 (22%)      8 (14%)                                            
      Bilateral, Pheochromocytoma Benign               5 (8%)       8 (13%)      9 (15%)                                            
   Islets, Pancreatic                                 (58)         (56)         (59)                                                
      Adenoma                                          5 (9%)       5 (9%)       1 (2%)                                             
   Parathyroid Gland                                  (56)         (54)         (51)                                                
      Adenoma                                                       1 (2%)                                                          
   Pituitary Gland                                    (56)         (59)         (56)                                                
      Pars Distalis, Adenoma                          23 (41%)     18 (31%)     13 (23%)                                            
      Pars Distalis, Adenoma, Multiple                              2 (3%)       1 (2%)                                             
   Thyroid Gland                                      (60)         (55)         (58)                                                
      C-Cell, Adenoma                                 12 (20%)      9 (16%)      9 (16%)                                            
      C-Cell, Carcinoma                                1 (2%)                    1 (2%)                                             
      Follicular Cell, Adenoma                         1 (2%)       1 (2%)                                                          
      Follicular Cell, Carcinoma                       1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (58)         (60)                                                
   Preputial Gland                                    (56)         (59)         (56)                                                
      Adenoma                                          3 (5%)       1 (2%)       3 (5%)                                             
      Carcinoma                                        1 (2%)                    1 (2%)                                             
      Bilateral, Adenoma                               1 (2%)                                                                       
   Testes                                             (60)         (60)         (60)                                                
      Bilateral, Interstitial Cell, Adenoma           40 (67%)     41 (68%)     44 (73%)                                            
      Interstitial Cell, Adenoma                      11 (18%)      9 (15%)      2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (58)         (60)                                                
   Lymph Node                                         (60)         (59)         (60)                                                
   Lymph Node, Mandibular                             (58)         (56)         (56)                                                
   Lymph Node, Mesenteric                             (59)         (54)         (58)                                                
   Spleen                                             (58)         (56)         (59)                                                
   Thymus                                             (55)         (50)         (52)                                                
____________________________________________________________________________________________________________________________________
                                                             Page   8                                                               
NTP Experiment-Test: 05047-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 09/06/94  
Route: GAVAGE                                                                                                     Time: 21:43:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0.025 G/     0.05 G/K                                               
                                                   79VM         KG 79 LM     G 79 HM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (42)         (36)         (41)                                                
      Fibroadenoma                                     4 (10%)      5 (14%)      2 (5%)                                             
      Fibroadenoma, Multiple                                        1 (3%)                                                          
   Skin                                               (58)         (60)         (59)                                                
      Carcinoma, Metastatic, Zymbal's Gland            1 (2%)                                                                       
      Keratoacanthoma                                  2 (3%)                    1 (2%)                                             
      Squamous Cell Papilloma                          1 (2%)                    1 (2%)                                             
      Sebaceous Gland, Adenoma                                      1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     5 (9%)       2 (3%)       3 (5%)                                             
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       2 (3%)                                                          
      Subcutaneous Tissue, Fibrous Histiocytoma        1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)                                                
      Osteoma                                                       1 (2%)                                                          
      Osteosarcoma                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (59)         (60)                                                
      Granular Cell Tumor Benign                       1 (2%)                                                                       
      Neoplasm NOS                                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)                                                
      Alveolar/Bronchiolar Adenoma                     3 (5%)       2 (3%)       5 (8%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Carcinoma, Metastatic, Zymbal's Gland            1 (2%)                                                                       
      Carcinoma Adenosquamous                          1 (2%)                                                                       
      Osteosarcoma, Metastatic                                      1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
   Nose                                               (59)         (60)         (56)                                                
      Schwannoma Benign                                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05047-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 09/06/94  
Route: GAVAGE                                                                                                     Time: 21:43:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0.025 G/     0.05 G/K                                               
                                                   79VM         KG 79 LM     G 79 HM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (3)          (1)                                                 
      Fibrosarcoma                                                               1 (100%)                                           
   Zymbal's Gland                                     (3)          (2)          (1)                                                 
      Carcinoma                                        3 (100%)     2 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)                                                
      Renal Tubule, Adenoma                            1 (2%)                                                                       
   Urinary Bladder                                    (60)         (55)         (56)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)                                                
      Leukemia Monocytic                               1 (2%)                                                                       
      Leukemia Mononuclear                            15 (25%)     12 (20%)     11 (18%)                                            
      Mesothelioma Malignant                                        3 (5%)       4 (7%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05047-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 09/06/94  
Route: GAVAGE                                                                                                     Time: 21:43:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      0.025 G/     0.05 G/K                                               
                                                   79VM         KG 79 LM     G 79 HM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            60          56          48                                                   
     Total Primary Neoplasms                          168         156         134                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 59          55          48                                                   
     Total Benign Neoplasms                           137         134         112                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              24          19          19                                                   
     Total Malignant Neoplasms                         31          21          22                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           1                                                               
     Total Metastatic Neoplasm                          3           1                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1                                                               
     Total Uncertain Neoplasms                                      1                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           

--multipart-boundary
Content-type: text/plain
Range: bytes 63525-63525/63525


--multipart-boundary--