National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1309

TR 399 Rat Pathology Tables

NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97
Route: GAVAGE                                                                                                     Time: 10:11:19




       Facility:  TSI Mason Research

       Chemical CAS #:  1271-19-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 4| 7| 4| 7| 7| 7| 7| 7| 5| 3| 7| 7| 6| 5| 4|             
                             DAY ON TEST   | 4| 4| 4| 4| 9| 5| 4| 0| 4| 0| 6| 5| 6| 5| 0| 5| 5| 4| 7| 8| 5| 5| 2| 7| 1|             
                                           | 3| 3| 9| 3| 4| 0| 4| 0| 9| 4| 4| 0| 3| 0| 2| 0| 0| 4| 4| 4| 0| 0| 2| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    79 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +     +  +  M  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Parasite                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Basophilic Focus                     | X  X  X     X  X  X     X        X     X  X  X  X  X              X      |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Fatty Change, Diffuse                |          2           2                                         2         |             
      Fatty Change, Focal                  |             2                                   2                 1     2|             
      Hepatodiaphragmatic Nodule           |                            X                       X                     |             
      Inflammation, Granulomatous          |                                                    2                     |             
      Mixed Cell Focus                     |       X                                                                  |             
      Necrosis                             | 1                    2                                                   |             
      Pigmentation                         | 2              2                                                         |             
      Thrombosis                           |                      1                                                   |             
      Bile Duct, Hyperplasia               | 2  2  2           2              2                                2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Acinus, Hyperplasia                  |                         2        2     2  2                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Acanthosis                           |          2        3  2                                         2         |             
      Hyperkeratosis                       |          1        2  3                                         2         |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis                             |          2        1                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Erosion                              |                                                                2         |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Bacterium                            |                      1                                                   |             
      Cardiomyopathy                       |    2     1        2  2  2        2           3     2           2        2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 4| 7| 4| 7| 7| 7| 7| 7| 5| 3| 7| 7| 6| 5| 4|             
                             DAY ON TEST   | 4| 4| 4| 4| 9| 5| 4| 0| 4| 0| 6| 5| 6| 5| 0| 5| 5| 4| 7| 8| 5| 5| 2| 7| 1|             
                                           | 3| 3| 9| 3| 4| 0| 4| 0| 9| 4| 4| 0| 3| 0| 2| 0| 0| 4| 4| 4| 0| 0| 2| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    79 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  M  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  M  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  M  +  +  +  +  M  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Hyperplasia                          |    1           1                             1                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  M  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M     +     +  +  +  M  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Cyst                                 |    X                                                                     |             
      Pars Distalis, Angiectasis           |          2     2        2        3     3     3  2  2        2            |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           | 2        2        2                                2        2     2      |             
      Pars Distalis, Pigmentation          |                                                                          |             
      Pars Intermedia, Cyst                |                                                                          |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      C-Cell, Hyperplasia                  | 2           1                                                     1      |             
      Follicle, Cyst                       |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  M  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Necrosis                             |             3                                                            |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Cyst                                 |    X        X                                                            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Cervix, Hemorrhage                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Mediastinal, Angiectasis             |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |       2  2  2                                                            |             
      Mediastinal, Pigmentation            |       2                                                                  |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |          2                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Infiltration Cellular, Histiocyte    |    1                    1                       2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Degeneration, Cystic                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 4| 7| 4| 7| 7| 7| 7| 7| 5| 3| 7| 7| 6| 5| 4|             
                             DAY ON TEST   | 4| 4| 4| 4| 9| 5| 4| 0| 4| 0| 6| 5| 6| 5| 0| 5| 5| 4| 7| 8| 5| 5| 2| 7| 1|             
                                           | 3| 3| 9| 3| 4| 0| 4| 0| 9| 4| 4| 0| 3| 0| 2| 0| 0| 4| 4| 4| 0| 0| 2| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    79 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 2  1  2  2           2  2                          2        2     2      |             
      Pigmentation                         | 2                                                                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Depletion Lymphoid                   |                                           2                              |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |    1  1        2     3     2     3     2  2  2     2     3     2         |             
      Infiltration Cellular, Histiocyte    | 2  2  3  1  3           2              2  2     2  3        3            |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            | 2  2  2     2  2                                                        3|             
      Pigmentation                         |                                                                          |             
      Capsule, Hemorrhage                  |                                                                          |             
      Capsule, Necrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M     +     +  +  +  +  +     +  +  +  +     M|             
      Cyst                                 |             X                                                            |             
      Depletion Lymphoid                   |                                                                          |             
      Pigmentation                         |                                                                1         |             
      Epithelial Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +     +     +  M  +  M  +     M  +  +  +     +|             
      Galactocele                          |                   X                    X                    X            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Abscess                              |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Atelectasis                          | 1                                                                        |             
      Bacterium                            |                      2                                                   |             
      Congestion                           |                                              3              2            |             
      Edema                                |                            2                 1                           |             
      Hemorrhage                           |                            2                                             |             
      Infiltration Cellular, Histiocyte    | 1     1  1              2              1  3                 1           1|             
      Inflammation, Acute                  |                                           2                              |             
      Metaplasia, Osseous                  |                                                                          |             
      Pigmentation                         |          1                                                               |             
      Alveolar Epithelium, Hyperplasia     |             2                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Fungus                               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 4| 7| 4| 7| 7| 7| 7| 7| 5| 3| 7| 7| 6| 5| 4|             
                             DAY ON TEST   | 4| 4| 4| 4| 9| 5| 4| 0| 4| 0| 6| 5| 6| 5| 0| 5| 5| 4| 7| 8| 5| 5| 2| 7| 1|             
                                           | 3| 3| 9| 3| 4| 0| 4| 0| 9| 4| 4| 0| 3| 0| 2| 0| 0| 4| 4| 4| 0| 0| 2| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    79 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                            1     1                                       |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Synechia                             |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Bacterium                            |                      3                                                   |             
      Inflammation, Chronic Active         |                      2                                                   |             
      Nephropathy                          |       1  1  1  3        1        1     1  2     1  2        2            |             
      Cortex, Mineralization               |                            1                       1                     |             
      Papilla, Mineralization              |                   1              1                                       |             
      Pelvis, Mineralization               |                                                                          |             
      Renal Tubule, Pigmentation           | 2  1  2  2  2  2  2                    2        1           1  3         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +|             
      Hemorrhage                           |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 5| 5| 3| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 4| 4| 7| 5| 5| 7| 6| 6| 6| 5|             
                             DAY ON TEST   | 9| 6| 7| 7| 4| 5| 5| 5| 4| 9| 4| 4| 5| 7| 7| 6| 6| 5| 7| 4| 0| 8| 5| 1| 7|             
                                           | 5| 3| 4| 4| 2| 0| 0| 0| 3| 3| 5| 4| 1| 4| 4| 3| 4| 0| 4| 9| 9| 8| 2| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    VEHICLE                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    79 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +           +  +  +  +  +  +  M  +  +              +     +  +  +  +  M   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +           +  +  +  +  +  +  +  +  +              +     +  A  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Parasite                             |                2                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +           +  +  +  +  +  +  +  +  +              +     +  A  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +           +  +  +  +  +  +  +  +  +              +     +  A  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +           +  +  +  +  +  +  +  +  +              +     +  A  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Basophilic Focus                     | X              X  X  X  X  X     X                 X     X  X  X     X   |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                1                                                         |             
      Fatty Change, Diffuse                |                            2  2                                          |             
      Fatty Change, Focal                  |             1                       1                             2  2   |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                                                2         |             
      Pigmentation                         |                                  1                                       |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               |                2  2                                2              2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Acanthosis                           |                               3                                2         |             
      Hyperkeratosis                       |                               2                                          |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Erosion                              |                               2                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Bacterium                            |                                                                          |             
      Cardiomyopathy                       |                2     2        2  2                 2        2  2         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 5| 5| 3| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 4| 4| 7| 5| 5| 7| 6| 6| 6| 5|             
                             DAY ON TEST   | 9| 6| 7| 7| 4| 5| 5| 5| 4| 9| 4| 4| 5| 7| 7| 6| 6| 5| 7| 4| 0| 8| 5| 1| 7|             
                                           | 5| 3| 4| 4| 2| 0| 0| 0| 3| 3| 5| 4| 1| 4| 4| 3| 4| 0| 4| 9| 9| 8| 2| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    VEHICLE                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    79 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Hyperplasia                          |                         2                                2               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Hyperplasia                          |                   1              3                       2               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +           +  +  +  +  +  +  M  +  +              +     +  +  +  +  M   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +           +  +  +  +  +  +  +  +  +              +     +  M  +  +  +   |             
      Cyst                                 |                                                                          |             
      Pars Distalis, Angiectasis           | 3                 3     2        2                 2     3     2     3   |             
      Pars Distalis, Cyst                  |                X        X                                                |             
      Pars Distalis, Hyperplasia           |                      2              2              2                     |             
      Pars Distalis, Pigmentation          |                                                                          |             
      Pars Intermedia, Cyst                |                      X                                                   |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      C-Cell, Hyperplasia                  |                            1                                   1         |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +           +  +  +  +  +  +  +  +  +              +     +  +  M  +  +   |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Cyst                                 | X                                                                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Cervix, Hemorrhage                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Mediastinal, Angiectasis             |                                                                2         |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                2                                   2           2         |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                    2                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Infiltration Cellular, Histiocyte    |                1        1                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Degeneration, Cystic                 |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 5| 5| 3| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 4| 4| 7| 5| 5| 7| 6| 6| 6| 5|             
                             DAY ON TEST   | 9| 6| 7| 7| 4| 5| 5| 5| 4| 9| 4| 4| 5| 7| 7| 6| 6| 5| 7| 4| 0| 8| 5| 1| 7|             
                                           | 5| 3| 4| 4| 2| 0| 0| 0| 3| 3| 5| 4| 1| 4| 4| 3| 4| 0| 4| 9| 9| 8| 2| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    VEHICLE                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    79 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                2  2  2  2        2                 2                     |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Depletion Lymphoid                   |                                                    2                     |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |             3     2  2  2                          2     3     3  1  2   |             
      Infiltration Cellular, Histiocyte    | 3              3     2     2     3                       2  2        2   |             
      Necrosis                             |                            2                                      3      |             
      Pigmentation, Hemosiderin            | 3                                1                       2               |             
      Pigmentation                         |                2                                                         |             
      Capsule, Hemorrhage                  |                                                                          |             
      Capsule, Necrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M           +  +  +  +  +  +  +  +  +              +     +  M  +  +  +   |             
      Cyst                                 |                                                                          |             
      Depletion Lymphoid                   |                                                                          |             
      Pigmentation                         |                1                 1                       1               |             
      Epithelial Cell, Hyperplasia         |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Galactocele                          | X                 X     X  X     X  X                                X   |             
                                            __________________________________________________________________________|             
   Skin                                    | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Atelectasis                          |                                  2                                       |             
      Bacterium                            |                                                                          |             
      Congestion                           |                                                                          |             
      Edema                                |                                                          2               |             
      Hemorrhage                           |                                                          2               |             
      Infiltration Cellular, Histiocyte    | 1                 1  1           1                       2  2  1         |             
      Inflammation, Acute                  |                                                          2               |             
      Metaplasia, Osseous                  |                                                             2            |             
      Pigmentation                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Fungus                               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 5| 5| 3| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 4| 4| 7| 5| 5| 7| 6| 6| 6| 5|             
                             DAY ON TEST   | 9| 6| 7| 7| 4| 5| 5| 5| 4| 9| 4| 4| 5| 7| 7| 6| 6| 5| 7| 4| 0| 8| 5| 1| 7|             
                                           | 5| 3| 4| 4| 2| 0| 0| 0| 3| 3| 5| 4| 1| 4| 4| 3| 4| 0| 4| 9| 9| 8| 2| 1| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    VEHICLE                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    79 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                                             2            |             
      Inflammation, Acute                  |                   1           1                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +                                          |             
      Synechia                             |                               2                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                               2                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Bacterium                            |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Nephropathy                          | 1              1     1  1  1     1                 1     2           2   |             
      Cortex, Mineralization               |             1                                                            |             
      Papilla, Mineralization              |                                                                1         |             
      Pelvis, Mineralization               |                                                          2               |             
      Renal Tubule, Pigmentation           |                2     1  2     1  1  1              1           1  2      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +           +  +  +  +  +  +  +  +  +              +     +  +  +  +  +   |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4| 4| 7| 7| 6| 5|             
                             DAY ON TEST   | 5| 5| 5| 4| 6| 6| 4| 5| 6| 5| 5| 1| 2| 1| 7| 5| 5| 5| 3| 6| 6| 5| 5| 2| 9|             
                                           | 0| 0| 0| 3| 4| 4| 4| 0| 3| 0| 0| 5| 4| 5| 4| 0| 0| 0| 9| 4| 3| 0| 0| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    79 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +        +  +     +  +  +  +  A     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +        +  +     +  +  +  +  +     M  +  +  M        +  +  +  +|             
      Parasite                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +        +  +     +  +  +  +  A     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +        +  +     +  +  +  +  A     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Basophilic Focus                     | X  X  X  X        X  X     X  X  X           X  X  X           X  X  X   |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Fatty Change, Diffuse                | 2                                   2  2              2              2  2|             
      Fatty Change, Focal                  |       1  2        1           1  2                             1         |             
      Hepatodiaphragmatic Nodule           |          X                                      X                        |             
      Inflammation, Granulomatous          |                      3                          2  2                     |             
      Mixed Cell Focus                     |                            X                                             |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                                                                          |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               |    2                                2  2     2        2        2         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
      Fat, Necrosis                        |                                                                   2      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Acinus, Hyperplasia                  |    3                 2                                                   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Acanthosis                           | 3        2                       2     1                             3   |             
      Hyperkeratosis                       | 2        2                       2     1                             2   |             
      Inflammation, Acute                  | 2                                                                        |             
      Necrosis                             |          3                       2     1                             2   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Erosion                              |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Bacterium                            |                                                                          |             
      Cardiomyopathy                       | 2                    2           2  2              2  2                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4| 4| 7| 7| 6| 5|             
                             DAY ON TEST   | 5| 5| 5| 4| 6| 6| 4| 5| 6| 5| 5| 1| 2| 1| 7| 5| 5| 5| 3| 6| 6| 5| 5| 2| 9|             
                                           | 0| 0| 0| 3| 4| 4| 4| 0| 3| 0| 0| 5| 4| 5| 4| 0| 0| 0| 9| 4| 3| 0| 0| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    79 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Hyperplasia                          |                                        1                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Hyperplasia                          | 1  2                          2  1     1              1                 1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Angiectasis           | 2  2     3           2     2     3  2        2     2                 3   |             
      Pars Distalis, Cyst                  |                                     X                                    |             
      Pars Distalis, Hyperplasia           |    1                                         2     2                     |             
      Pars Distalis, Pigmentation          |                                                                          |             
      Pars Intermedia, Cyst                |                                                                          |             
      Pars Intermedia, Hyperplasia         |       2                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      C-Cell, Hyperplasia                  |                            1                                      1     2|             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +        +  M     +  M  +  +  +     +  +  +  +        +  +  +  +|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Cervix, Hemorrhage                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                     +                 +                  |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Mediastinal, Angiectasis             |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |          2        2           2              1     2           1         |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                              2                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        M  +  M  +|             
      Infiltration Cellular, Histiocyte    |                   1           1                 1                 1      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4| 4| 7| 7| 6| 5|             
                             DAY ON TEST   | 5| 5| 5| 4| 6| 6| 4| 5| 6| 5| 5| 1| 2| 1| 7| 5| 5| 5| 3| 6| 6| 5| 5| 2| 9|             
                                           | 0| 0| 0| 3| 4| 4| 4| 0| 3| 0| 0| 5| 4| 5| 4| 0| 0| 0| 9| 4| 3| 0| 0| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    79 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |       2  2        2  2     2  1              2  2  2           2  2  2   |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis                             |                                        1                                 |             
      Hematopoietic Cell Proliferation     | 2  2  2              2     2  1              2  2     2                 2|             
      Infiltration Cellular, Histiocyte    | 2     2  3        3  1     2  1              2  2  2           2  2  2   |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Pigmentation                         |                                                                          |             
      Capsule, Hemorrhage                  |                                     2                                    |             
      Capsule, Necrosis                    |                                     3                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +        M  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Cyst                                 |                                                                          |             
      Depletion Lymphoid                   |                                     2                                    |             
      Pigmentation                         |                                                                1         |             
      Epithelial Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Galactocele                          | X  X  X  X        X  X     X  X                    X              X  X   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Atelectasis                          |                                                                   1      |             
      Bacterium                            |                                                                          |             
      Congestion                           |                            2                                             |             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |    2              1           2                    1  2           1      |             
      Inflammation, Acute                  |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Pigmentation                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Fungus                               |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 4| 4| 7| 7| 6| 5|             
                             DAY ON TEST   | 5| 5| 5| 4| 6| 6| 4| 5| 6| 5| 5| 1| 2| 1| 7| 5| 5| 5| 3| 6| 6| 5| 5| 2| 9|             
                                           | 0| 0| 0| 3| 4| 4| 4| 0| 3| 0| 0| 5| 4| 5| 4| 0| 0| 0| 9| 4| 3| 0| 0| 4| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    79 VF                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                              2  1                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +  +                    +                  |             
      Synechia                             |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                  2                                       |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +  +                    +                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Bacterium                            |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Nephropathy                          | 2  1     2           1     1  2     2           2     1        1     3   |             
      Cortex, Mineralization               |                   1                                                      |             
      Papilla, Mineralization              |                   1  1                                                   |             
      Pelvis, Mineralization               |                                     1                                    |             
      Renal Tubule, Pigmentation           | 1  1  2           2  1     1  2     2           2  1           1        2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +        +  +     +  +  +  +  +     +  +  +  +        +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5|                                                           |            |
                             DAY ON TEST   | 5| 5| 4| 0| 7|                                                           |            |
                                           | 0| 0| 4| 7| 4|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6|                                                           |      A     |
    VEHICLE                                | 4| 4| 4| 4| 4|                                                           |      L     |
    79 VF                                  | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +                                                               |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +                                                               |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +                                                               |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +                                                               |  57        |
      Parasite                             |       1                                                                  |      2  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +                                                               |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +                                                               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +                                                               |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +                                                               |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +                                                               |  58        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +                                                               |  60        |
      Basophilic Focus                     | X  X  X  X                                                               |     45     |
      Clear Cell Focus                     |       X                                                                  |      1     |
      Degeneration, Cystic                 |                                                                          |      1  1.0|
      Fatty Change, Diffuse                |                                                                          |     11  2.0|
      Fatty Change, Focal                  |          2                                                               |     15  1.5|
      Hepatodiaphragmatic Nodule           |                                                                          |      4     |
      Inflammation, Granulomatous          |    1  2                                                                  |      6  2.0|
      Mixed Cell Focus                     |                                                                          |      2     |
      Necrosis                             |                                                                          |      3  1.7|
      Pigmentation                         |                                                                          |      3  1.7|
      Thrombosis                           |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               |          2                                                               |     17  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Fat, Necrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +                                                               |  60        |
      Acinus, Hyperplasia                  |                                                                          |      6  2.2|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +                                                               |  60        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +                                                               |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +                                                               |  60        |
      Acanthosis                           |                                                                          |     11  2.3|
      Hyperkeratosis                       |                                                                          |     10  1.9|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      6  1.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +                                                               |  60        |
      Erosion                              |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5|                                                           |            |
                             DAY ON TEST   | 5| 5| 4| 0| 7|                                                           |            |
                                           | 0| 0| 4| 7| 4|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6|                                                           |      A     |
    VEHICLE                                | 4| 4| 4| 4| 4|                                                           |      L     |
    79 VF                                  | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +                                                               |  60        |
      Bacterium                            |                                                                          |      1  1.0|
      Cardiomyopathy                       |                                                                          |     23  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +                                                               |  59        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +                                                               |  59        |
      Hyperplasia                          |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +                                                               |  58        |
      Hyperplasia                          |                                                                          |     13  1.4|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +                                                               |  59        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M                                                               |  55        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +                                                               |  59        |
      Cyst                                 |                                                                          |      1     |
      Pars Distalis, Angiectasis           |                                                                          |     27  2.4|
      Pars Distalis, Cyst                  |       X                                                                  |      4     |
      Pars Distalis, Hyperplasia           |          2                                                               |     13  1.9|
      Pars Distalis, Pigmentation          |          2                                                               |      1  2.0|
      Pars Intermedia, Cyst                |                                                                          |      1     |
      Pars Intermedia, Hyperplasia         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +                                                               |  60        |
      C-Cell, Hyperplasia                  |                                                                          |      8  1.3|
      Follicle, Cyst                       |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +                                                               |  56        |
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  M                                                               |  58        |
      Cyst                                 |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +                                                               |  60        |
      Cervix, Hemorrhage                   |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +                                                               |  59        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +                                                               |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5|                                                           |            |
                             DAY ON TEST   | 5| 5| 4| 0| 7|                                                           |            |
                                           | 0| 0| 4| 7| 4|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6|                                                           |      A     |
    VEHICLE                                | 4| 4| 4| 4| 4|                                                           |      L     |
    79 VF                                  | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Angiectasis             |                                                                          |      1  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                                          |     12  1.8|
      Mediastinal, Pigmentation            |                                                                          |      1  2.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  M                                                               |  56        |
      Infiltration Cellular, Histiocyte    |                                                                          |      9  1.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +                                                               |  60        |
      Degeneration, Cystic                 |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    |                                                                          |     27  1.9|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +                                                               |  60        |
      Depletion Lymphoid                   |                                                                          |      2  2.0|
      Fibrosis                             |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     | 2  2                                                                     |     33  2.1|
      Infiltration Cellular, Histiocyte    |    2  2                                                                  |     34  2.2|
      Necrosis                             |                                                                          |      2  2.5|
      Pigmentation, Hemosiderin            |                                                                          |      9  2.1|
      Pigmentation                         |                                                                          |      1  2.0|
      Capsule, Hemorrhage                  |                                                                          |      1  2.0|
      Capsule, Necrosis                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +                                                               |  55        |
      Cyst                                 |                                                                          |      1     |
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      5  1.0|
      Epithelial Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +                                                               |  56        |
      Galactocele                          |                                                                          |     21     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +                                                               |  60        |
      Abscess                              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +                                                               |  60        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +                                                               |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5|                                                           |            |
                             DAY ON TEST   | 5| 5| 4| 0| 7|                                                           |            |
                                           | 0| 0| 4| 7| 4|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6|                                                           |      A     |
    VEHICLE                                | 4| 4| 4| 4| 4|                                                           |      L     |
    79 VF                                  | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +                                                               |  60        |
      Atelectasis                          |                                                                          |      3  1.3|
      Bacterium                            |                                                                          |      1  2.0|
      Congestion                           |                                                                          |      3  2.3|
      Edema                                |                                                                          |      3  1.7|
      Hemorrhage                           |                                                                          |      2  2.0|
      Infiltration Cellular, Histiocyte    |    3                                                                     |     22  1.5|
      Inflammation, Acute                  |                                                                          |      2  2.0|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +                                                               |  60        |
      Fungus                               |                                                                          |      1  2.0|
      Hemorrhage                           |    2                                                                     |      2  2.0|
      Inflammation, Acute                  |       1                                                                  |      7  1.1|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +                                                               |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                                               |   5        |
      Synechia                             |          2                                                               |      2  2.0|
      Lens, Cataract                       |          2                                                               |      1  2.0|
      Retina, Atrophy                      |          2                                                               |      3  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +                                                               |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +                                                               |  60        |
      Bacterium                            |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Nephropathy                          |    1                                                                     |     32  1.4|
      Cortex, Mineralization               |                                                                          |      4  1.0|
      Papilla, Mineralization              |                                                                          |      5  1.0|
      Pelvis, Mineralization               |                                                                          |      2  1.5|
      Renal Tubule, Pigmentation           | 1  1  2                                                                  |     35  1.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +                                                               |  60        |
      Hemorrhage                           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 1| 7| 7| 7| 5| 5| 7| 7| 7| 4| 6| 7| 4| 7| 7| 5| 7| 4| 7| 6| 5|             
                             DAY ON TEST   | 4| 4| 4| 7| 7| 4| 4| 4| 9| 7| 4| 4| 2| 6| 3| 4| 6| 4| 0| 4| 4| 6| 4| 4| 7|             
                                           | 9| 9| 3| 4| 7| 9| 9| 9| 0| 4| 9| 9| 1| 4| 9| 9| 4| 4| 7| 9| 9| 4| 9| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.025 G/                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    KG 79 LF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +     +  +  +     +  M     +  +  +  +     +  +   |             
      Erosion                              |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     A  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     A  +  +  +  +     +  +  +     +  +     +  +  A  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     A  +  +  +  +     +  +  +     +  +     +  +  A  +     +  +   |             
      Hyperplasia, Adenomatous             |                                     2                                    |             
      Pigmentation                         | 1              1  1  1        1  1  1     1  1     1  1              1   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     A  +  +  +  +     +  +  +     +  +     +  +  A  +     +  +   |             
      Fibrosis                             |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     A  +  +  +  +     +  +  +     +  +     +  +  A  +     +  +   |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Angiectasis                          |                                                             1            |             
      Basophilic Focus                     |    X  X        X  X  X        X  X           X     X  X     X     X  X   |             
      Clear Cell Focus                     |    X  X                                                                  |             
      Degeneration, Cystic                 |                                                                          |             
      Fatty Change, Diffuse                |                         2           3                                    |             
      Fatty Change, Focal                  |                                           2              2           1   |             
      Hepatodiaphragmatic Nodule           |    X                                X        X                           |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Granulomatous          |                1  3  2        1  1        1  2                    3  2   |             
      Mixed Cell Focus                     |                                  X           X                           |             
      Necrosis                             |                                           1                              |             
      Pigmentation                         | 1  1  1        1  2  1        2  1  1     1  2     1  1  1  1     2  1   |             
      Bile Duct, Hyperplasia               | 2                                2                 2                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +                           |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
      Fat, Necrosis                        |                                              2                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Acinus, Atrophy                      |                                     3                                    |             
      Acinus, Hyperplasia                  |                2                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Fat, Proliferation                   |                         1        1  1     1           1                  |             
      Polyp Adenomatous, Inflammation      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Acanthosis                           |    2              2                                   2              2   |             
      Hyperkeratosis                       |    2        2     2     1                 2           2              2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 1| 7| 7| 7| 5| 5| 7| 7| 7| 4| 6| 7| 4| 7| 7| 5| 7| 4| 7| 6| 5|             
                             DAY ON TEST   | 4| 4| 4| 7| 7| 4| 4| 4| 9| 7| 4| 4| 2| 6| 3| 4| 6| 4| 0| 4| 4| 6| 4| 4| 7|             
                                           | 9| 9| 3| 4| 7| 9| 9| 9| 0| 4| 9| 9| 1| 4| 9| 9| 4| 4| 7| 9| 9| 4| 9| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.025 G/                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    KG 79 LF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Erosion                              |                         1           1                       1            |             
      Fibrosis                             |    1  1        2     1  2        2  2     2           2  2           2   |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                1        2        1  2     2           1              1   |             
      Hyperplasia, Adenomatous             |                                                             2            |             
      Inflammation, Acute                  |                                                                      1   |             
      Metaplasia                           |                1     1  1        1  2     2           1  2           1   |             
      Mineralization                       |                   2                                                      |             
      Pigmentation                         |       1              1  1        1  1     1           1                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Cardiomyopathy                       |    2  2        2  2  2           2           2     2                     |             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Degeneration, Cystic                 | 3                                                                        |             
      Degeneration                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |    2                                               2                     |             
      Necrosis                             |                                                                          |             
      Pigmentation, Ceroid                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Hyperplasia                          |                                              2     2                 1   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +     M  +  +  +  +     +  +  +     +  +     +  +  M  +     M  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +  M     +  +  +     +  +     +  +  +  +     +  +   |             
      Pars Distalis, Angiectasis           | 2  2  2           2  2        2  2  2     3           1              3   |             
      Pars Distalis, Cyst                  |                                  X                                       |             
      Pars Distalis, Hyperplasia           |                                  2           2              2            |             
      Pars Intermedia, Cyst                |                                                                          |             
      Pars Nervosa, Cyst                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     A  +  +  +  +     +  +  +     +  +     +  +  A  +     +  +   |             
      C-Cell, Hyperplasia                  | 1  2                    1           2     1           1     1        1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +     +  +  +  +  +     +  +  +     +  +     +  M  +  +     +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 1| 7| 7| 7| 5| 5| 7| 7| 7| 4| 6| 7| 4| 7| 7| 5| 7| 4| 7| 6| 5|             
                             DAY ON TEST   | 4| 4| 4| 7| 7| 4| 4| 4| 9| 7| 4| 4| 2| 6| 3| 4| 6| 4| 0| 4| 4| 6| 4| 4| 7|             
                                           | 9| 9| 3| 4| 7| 9| 9| 9| 0| 4| 9| 9| 1| 4| 9| 9| 4| 4| 7| 9| 9| 4| 9| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.025 G/                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    KG 79 LF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Cyst                                 |                               X                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia, Tubular                 |                2                                                         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Hemorrhage                           |                                                                          |             
      Endometrium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Pigmentation                         | 1                                         1                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Mediastinal, Hemorrhage              |                                                          2               |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |       1        2        2     2           1  1                    1      |             
      Mediastinal, Pigmentation            |       1        1              2     2     1  1                    1      |             
      Pancreatic, Angiectasis              |                                                                   3      |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                2              2                                          |             
      Pancreatic, Pigmentation             | 2     2        3              3                                   2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  M   |             
      Infiltration Cellular, Histiocyte    |                      2  1                                1               |             
      Pigmentation                         |    1  1           1           2     2     1  2        1     1     1      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Depletion Lymphoid                   |                                           3                              |             
      Infiltration Cellular, Histiocyte    | 2  2  2        2  2  2  1     2  2  2        2        2  2               |             
      Pigmentation                         | 2  2  3        2  2  2  2     2  2  2     3  2        2     2     2  2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |       2        3  2  2        2     2     2  2        2     2     2      |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |       1              2  1     1           2  2           2  2            |             
      Pigmentation, Hemosiderin            |       1           2  2        2           2  2              2        2   |             
      Pigmentation                         |    2  2        1  2  2        2     2     2  2        2     2     2  2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Cyst                                 |                                                             X            |             
      Depletion Lymphoid                   |                                                                          |             
      Pigmentation                         | 1  1  1        2  1  1        1     1     1  1     1  1  1  1            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 1| 7| 7| 7| 5| 5| 7| 7| 7| 4| 6| 7| 4| 7| 7| 5| 7| 4| 7| 6| 5|             
                             DAY ON TEST   | 4| 4| 4| 7| 7| 4| 4| 4| 9| 7| 4| 4| 2| 6| 3| 4| 6| 4| 0| 4| 4| 6| 4| 4| 7|             
                                           | 9| 9| 3| 4| 7| 9| 9| 9| 0| 4| 9| 9| 1| 4| 9| 9| 4| 4| 7| 9| 9| 4| 9| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.025 G/                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    KG 79 LF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     M  +  +  +  +     +  +  +     +  +     +  +  +  M     +  +   |             
      Galactocele                          |    X  X           X                       X                              |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Atelectasis                          |                                              2                       1   |             
      Congestion                           |             3                                2                           |             
      Edema                                |                                                          3               |             
      Hemorrhage                           |                                           1                              |             
      Infiltration Cellular, Histiocyte    | 2  1  1        1  2  2  1     1  1  1     1  1     1  1     2     2  2   |             
      Inflammation, Acute                  |                                                          3               |             
      Inflammation, Granulomatous          |                                                                      1   |             
      Pigmentation                         | 1                 1  1                       1           2           2   |             
      Alveolar Epithelium, Hyperplasia     |                               2                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Fungus                               |                                                                          |             
      Inflammation, Acute                  |                      1        1                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  A  +     +  +   |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                           +                              |             
      Canal, Abscess                       |                                           4                              |             
                                            __________________________________________________________________________|             
   Eye                                     |                                     +     +                              |             
      Inflammation, Acute                  |                                                                          |             
      Synechia                             |                                                                          |             
      Lens, Cataract                       |                                     2     2                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                     +     +                              |             
      Pigmentation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
      Cyst                                 |    X                                                                     |             
      Nephropathy                          | 1     1           2  1        1  2  1     2  1     1        2            |             
      Cortex, Mineralization               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 1| 7| 7| 7| 5| 5| 7| 7| 7| 4| 6| 7| 4| 7| 7| 5| 7| 4| 7| 6| 5|             
                             DAY ON TEST   | 4| 4| 4| 7| 7| 4| 4| 4| 9| 7| 4| 4| 2| 6| 3| 4| 6| 4| 0| 4| 4| 6| 4| 4| 7|             
                                           | 9| 9| 3| 4| 7| 9| 9| 9| 0| 4| 9| 9| 1| 4| 9| 9| 4| 4| 7| 9| 9| 4| 9| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.025 G/                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    KG 79 LF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Papilla, Mineralization              |                   1              1        1                 1            |             
      Renal Tubule, Pigmentation           | 1  1  1        1  2  2  1     1              1     1  1           1      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +  +     +  +  +     +  +     +  +  +  +     +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 5| 5| 7| 6| 4| 6| 4| 7| 6| 5| 5| 4| 7| 7| 4| 6| 5| 7| 4| 7| 7| 5|             
                             DAY ON TEST   | 9| 9| 6| 9| 7| 2| 8| 6| 3| 5| 4| 1| 7| 7| 6| 4| 4| 6| 0| 1| 4| 6| 4| 4| 7|             
                                           | 4| 2| 0| 5| 0| 1| 8| 3| 1| 1| 9| 0| 4| 4| 4| 9| 9| 3| 8| 0| 9| 3| 9| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.025 G/                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    KG 79 LF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +     +  A  +  +        +  +  +     +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +     +  A  +  +        +  +  +     A  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +     +  A  +  +        +  +  +     +  +  +     +  +   |             
      Erosion                              |                2                                                         |             
      Inflammation, Acute                  |                3                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +     +  A  +  +        +  +  +     +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  A  +  +     +  A  +  +        +  +  +     +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +     +  A  +  +        +  +  +     +  +  +     +  +   |             
      Hyperplasia, Adenomatous             |                                                                          |             
      Pigmentation                         |    1  1        1                                1                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +     +  A  +  +        +  +  +     A  +  +     +  +   |             
      Fibrosis                             |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +     +  A  +  +        +  +  +     A  +  +     +  +   |             
      Pigmentation                         |                   1                                                      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Angiectasis                          |                1                                                         |             
      Basophilic Focus                     |    X  X        X              X           X  X  X     X  X  X     X  X   |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                                                             1            |             
      Fatty Change, Diffuse                |             2           4        2                                       |             
      Fatty Change, Focal                  | 2              2                                            1            |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Granulomatous          |                               2              2  1           2     2  2   |             
      Mixed Cell Focus                     |          X                    X              X                           |             
      Necrosis                             |                   2              2                                       |             
      Pigmentation                         | 2  1  1        2  1           2              2  1           2     2  1   |             
      Bile Duct, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                      +                           |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
      Fat, Necrosis                        |       2                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Hyperplasia                  |                                                                      2   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +     +  A  +  +        +  +  +     +  +  +     +  +   |             
      Fat, Proliferation                   |       1  1              1                                                |             
      Polyp Adenomatous, Inflammation      |                   2                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +     +  A  +  +        +  +  +     +  +  +     +  +   |             
      Acanthosis                           |       2                       2              2              2     2  2   |             
      Hyperkeratosis                       |       2                 2                             2              2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 5| 5| 7| 6| 4| 6| 4| 7| 6| 5| 5| 4| 7| 7| 4| 6| 5| 7| 4| 7| 7| 5|             
                             DAY ON TEST   | 9| 9| 6| 9| 7| 2| 8| 6| 3| 5| 4| 1| 7| 7| 6| 4| 4| 6| 0| 1| 4| 6| 4| 4| 7|             
                                           | 4| 2| 0| 5| 0| 1| 8| 3| 1| 1| 9| 0| 4| 4| 4| 9| 9| 3| 8| 0| 9| 3| 9| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.025 G/                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    KG 79 LF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +     +  A  +  +        +  +  +     +  +  +     +  +   |             
      Erosion                              |                   2     2                 2                              |             
      Fibrosis                             |    2  2  2  1  1  4     3                             2  2  1     2  2   |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |    1  1  2     1        1                                1           1   |             
      Hyperplasia, Adenomatous             |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Metaplasia                           |    2  2  1     1        1     1                          1           2   |             
      Mineralization                       | 2  2     2        2                                               1      |             
      Pigmentation                         |    1           1              1                             1     1  1   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Cardiomyopathy                       |    2        2                                   2                 2      |             
      Mineralization                       |    2                                                                     |             
      Thrombosis                           |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Degeneration, Cystic                 |                                                                          |             
      Degeneration                         |          3                                                               |             
      Hemorrhage                           |                                           2                              |             
      Hyperplasia                          |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation, Ceroid                 |          2                                                               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +     +  +  +  M        +  +  +     +  +  +     +  +   |             
      Hyperplasia                          |                   2                       2                 2            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +     +  +  M  +        +  +  +     +  +  +     +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Pars Distalis, Angiectasis           | 2        2              3     2              2                           |             
      Pars Distalis, Cyst                  |                                  X                                X      |             
      Pars Distalis, Hyperplasia           | 3           2  3                 2           2              2            |             
      Pars Intermedia, Cyst                |                                                                          |             
      Pars Nervosa, Cyst                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +     +  A  +  +        +  +  +     A  +  +     +  +   |             
      C-Cell, Hyperplasia                  | 1              1        2                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 5| 5| 7| 6| 4| 6| 4| 7| 6| 5| 5| 4| 7| 7| 4| 6| 5| 7| 4| 7| 7| 5|             
                             DAY ON TEST   | 9| 9| 6| 9| 7| 2| 8| 6| 3| 5| 4| 1| 7| 7| 6| 4| 4| 6| 0| 1| 4| 6| 4| 4| 7|             
                                           | 4| 2| 0| 5| 0| 1| 8| 3| 1| 1| 9| 0| 4| 4| 4| 9| 9| 3| 8| 0| 9| 3| 9| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.025 G/                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    KG 79 LF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Cyst                                 |    X           X                                                         |             
      Degeneration, Cystic                 |                   2                                                      |             
      Hyperplasia, Tubular                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Hemorrhage                           |                   3                                                      |             
      Endometrium, Hyperplasia             |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Pigmentation                         |                1                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |    1     2        2                          1  1                    1   |             
      Mediastinal, Pigmentation            | 1  2           2  2                          1  2                    1   |             
      Pancreatic, Angiectasis              |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                                          |             
      Pancreatic, Pigmentation             |                2                                2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +     +  +  M  +        +  +  +     +  +  +     +  +   |             
      Infiltration Cellular, Histiocyte    |                                           1                              |             
      Pigmentation                         |       2        2  2                          1  2     1     1     1  1   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Depletion Lymphoid                   |                                                                          |             
      Infiltration Cellular, Histiocyte    | 2  2  2  2        2     2  2  2  2        2     2        2        3  2   |             
      Pigmentation                         | 2  2  2  2     2  2           2              2  2     2     2     3  2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +     +  +  +  +        +  +  +     M  +  +     +  +   |             
      Depletion Lymphoid                   |    2                                                                     |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |    2  2  3  2     3     2     2           2  2  2        2  2     2  2   |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                         2     2           2  1  2           2     1  2   |             
      Pigmentation, Hemosiderin            |                1              2              1  2           2     2  2   |             
      Pigmentation                         | 2  2  2        2              2              2  2           2     2  2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +     +  +  +  +        +  M  +     +  +  +     +  +   |             
      Cyst                                 |                                                                          |             
      Depletion Lymphoid                   |                   2                                                      |             
      Pigmentation                         | 1  1     1     1  1              1                    1     1        1   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 5| 5| 7| 6| 4| 6| 4| 7| 6| 5| 5| 4| 7| 7| 4| 6| 5| 7| 4| 7| 7| 5|             
                             DAY ON TEST   | 9| 9| 6| 9| 7| 2| 8| 6| 3| 5| 4| 1| 7| 7| 6| 4| 4| 6| 0| 1| 4| 6| 4| 4| 7|             
                                           | 4| 2| 0| 5| 0| 1| 8| 3| 1| 1| 9| 0| 4| 4| 4| 9| 9| 3| 8| 0| 9| 3| 9| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.025 G/                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    KG 79 LF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +     +  +  +  +        +  +  M     +  +  +     +  +   |             
      Galactocele                          | X                       X        X           X              X            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Hemorrhage                           | 1                                                                        |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Atelectasis                          |          2                                2                              |             
      Congestion                           |                                                       3                  |             
      Edema                                |                                                       2                  |             
      Hemorrhage                           |                         2  3                          2                  |             
      Infiltration Cellular, Histiocyte    | 1  2  1        1  1     1     2           1  1  2           1        2   |             
      Inflammation, Acute                  |                                           1                              |             
      Inflammation, Granulomatous          |                                                                          |             
      Pigmentation                         |    2  1  2     1                             1                       1   |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Fungus                               |                                                                          |             
      Inflammation, Acute                  |    2  1     3           2                                                |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +     +  +  +  +        +  +  +     A  +  +     +  +   |             
      Inflammation, Acute                  |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Canal, Abscess                       |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                            |             
      Inflammation, Acute                  |                                                                          |             
      Synechia                             |                                                                          |             
      Lens, Cataract                       |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Pigmentation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +     +  +  +  +        +  +  +     +  +  +     +  +   |             
      Cyst                                 |                                                                          |             
      Nephropathy                          |    2     1              2     2              1  2           1     1  1   |             
      Cortex, Mineralization               |    2              2                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 5| 5| 7| 6| 4| 6| 4| 7| 6| 5| 5| 4| 7| 7| 4| 6| 5| 7| 4| 7| 7| 5|             
                             DAY ON TEST   | 9| 9| 6| 9| 7| 2| 8| 6| 3| 5| 4| 1| 7| 7| 6| 4| 4| 6| 0| 1| 4| 6| 4| 4| 7|             
                                           | 4| 2| 0| 5| 0| 1| 8| 3| 1| 1| 9| 0| 4| 4| 4| 9| 9| 3| 8| 0| 9| 3| 9| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.025 G/                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    KG 79 LF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Papilla, Mineralization              | 2                                                                    1   |             
      Renal Tubule, Pigmentation           | 1        1     1  2     1                 1  1              1            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +     +  A  +  +        +     +     A  +  +     +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 7| 6| 7| 4| 6| 5| 3| 4| 7| 6| 5| 5| 7| 7| 6| 5| 4| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 6| 4| 6| 1| 4| 4| 6| 6| 7| 5| 6| 4| 4| 7| 0| 4| 4| 4| 7| 3| 4| 4| 4| 8| 4|             
                                           | 3| 4| 3| 5| 3| 3| 3| 1| 4| 0| 3| 3| 5| 4| 4| 9| 9| 5| 4| 0| 4| 9| 3| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.025 G/                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    KG 79 LF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Adenomatous             |                                                                          |             
      Pigmentation                         |    1     1           1           1           1  1           1  1         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                  2                                       |             
      Inflammation, Acute                  |    3                             2                                       |             
      Pigmentation                         |                                  1                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |    X           X     X     X     X  X     X  X  X  X  X     X  X  X  X  X|             
      Clear Cell Focus                     |                                                                         X|             
      Degeneration, Cystic                 |                                                                          |             
      Fatty Change, Diffuse                |          2                                                               |             
      Fatty Change, Focal                  |             1              1              2  2     1                     |             
      Hepatodiaphragmatic Nodule           |                                                 X                 X  X   |             
      Hyperplasia                          |                                              2                           |             
      Inflammation, Granulomatous          |    2           2     2           3                          1  2        1|             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                                 1  2                     |             
      Pigmentation                         |    2        1  2     1           1  1        1  1  1        2  1  1  1  1|             
      Bile Duct, Hyperplasia               |             2                                                            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +     +     +     +                  |             
      Fat, Inflammation, Chronic Active    |                                                       2                  |             
      Fat, Necrosis                        |                                     2     4     2     2                  |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Hyperplasia                  |                                           2     2                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Fat, Proliferation                   |                1                 1  1        1        1           1      |             
      Polyp Adenomatous, Inflammation      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |    2     2  2        2                       2     2        3           2|             
      Hyperkeratosis                       |          2  2        2              2     2  2     3  2     3           2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 7| 6| 7| 4| 6| 5| 3| 4| 7| 6| 5| 5| 7| 7| 6| 5| 4| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 6| 4| 6| 1| 4| 4| 6| 6| 7| 5| 6| 4| 4| 7| 0| 4| 4| 4| 7| 3| 4| 4| 4| 8| 4|             
                                           | 3| 4| 3| 5| 3| 3| 3| 1| 4| 0| 3| 3| 5| 4| 4| 9| 9| 5| 4| 0| 4| 9| 3| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.025 G/                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    KG 79 LF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |          1  1                             1           1     2            |             
      Fibrosis                             |    2     1  2  2     2           2  2        2  1  2  2  2  2     2      |             
      Hemorrhage                           |                                           2           1  1               |             
      Hyperplasia                          |    1     1  2        1     1                 1     1  1  2  3            |             
      Hyperplasia, Adenomatous             |                                                                          |             
      Inflammation, Acute                  |             2                             2           1                  |             
      Metaplasia                           |    1     1  1  2     2     1     1  2        1  1  2  2  1  1     1     1|             
      Mineralization                       |                                                                      2   |             
      Pigmentation                         |    1           2                          1        1  1                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2     2     2                    2     2  2        2           2      |             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Degeneration                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Necrosis                             |                                                    2                     |             
      Pigmentation, Ceroid                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            1                                             |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +     +  +  +     +     +     M  +     +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |             2        2              2           2     2                  |             
      Pars Distalis, Cyst                  |                                           X                              |             
      Pars Distalis, Hyperplasia           |    2     2     2                             2  2           2  2  2  3   |             
      Pars Intermedia, Cyst                |                                                                          |             
      Pars Nervosa, Cyst                   |                                           X                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                              1  1  1        2     2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +     +  +  +     M     +     +  +     +  +  +  M  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 7| 6| 7| 4| 6| 5| 3| 4| 7| 6| 5| 5| 7| 7| 6| 5| 4| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 6| 4| 6| 1| 4| 4| 6| 6| 7| 5| 6| 4| 4| 7| 0| 4| 4| 4| 7| 3| 4| 4| 4| 8| 4|             
                                           | 3| 4| 3| 5| 3| 3| 3| 1| 4| 0| 3| 3| 5| 4| 4| 9| 9| 5| 4| 0| 4| 9| 3| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.025 G/                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    KG 79 LF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |          3                                                               |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             X  X                             X                           |             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia, Tubular                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                     3                                    |             
      Endometrium, Hyperplasia             |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |                1     1                                      1        1  1|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |    2                                                                     |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |    1     1                       1  1           2  2                 1   |             
      Mediastinal, Pigmentation            |    2     1                       1  2           2  2                 2   |             
      Pancreatic, Angiectasis              |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |    2        2                                                            |             
      Pancreatic, Pigmentation             |             2  3                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                                          1               |             
      Pigmentation                         |    1     1  1  2     1           1  1              1        1  1     2  1|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Infiltration Cellular, Histiocyte    |          2  2        2           2  2     3     2  2  3  2     2  2  2  2|             
      Pigmentation                         |    2     2  2  2     2           2  2           2  2  2     2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Spleen                                  |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                  1                                       |             
      Fibrosis                             |    2                                                                     |             
      Hematopoietic Cell Proliferation     |    2     3     1     1     3     2  2     1     3  2  1  2  2     3     2|             
      Hemorrhage                           |                2                                                         |             
      Infiltration Cellular, Histiocyte    |                      1              1     2        2  2  2  1  2        1|             
      Pigmentation, Hemosiderin            |                1     1           1  2              2        2  2        2|             
      Pigmentation                         |    2                             1  2           1  2        2  2        2|             
                                            __________________________________________________________________________|             
   Thymus                                  |    +     +  +  +     M     +     +  +     +  +  +  M  +  +  +  +  +  +  M|             
      Cyst                                 |                                                                          |             
      Depletion Lymphoid                   |                                                                          |             
      Pigmentation                         |    1     1  1                    1  1           1           1  1  1  1   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 7| 6| 7| 4| 6| 5| 3| 4| 7| 6| 5| 5| 7| 7| 6| 5| 4| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 6| 4| 6| 1| 4| 4| 6| 6| 7| 5| 6| 4| 4| 7| 0| 4| 4| 4| 7| 3| 4| 4| 4| 8| 4|             
                                           | 3| 4| 3| 5| 3| 3| 3| 1| 4| 0| 3| 3| 5| 4| 4| 9| 9| 5| 4| 0| 4| 9| 3| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.025 G/                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    KG 79 LF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  M  +  +  +|             
      Galactocele                          |                                              X                       X   |             
                                            __________________________________________________________________________|             
   Skin                                    |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Atelectasis                          |                                                                          |             
      Congestion                           |                                                          2               |             
      Edema                                |                                                       2                  |             
      Hemorrhage                           |                      1           1                                       |             
      Infiltration Cellular, Histiocyte    |    2     1  1  2     1           2  1        1  1  1  1     1  2  1     2|             
      Inflammation, Acute                  |                            1                          1                  |             
      Inflammation, Granulomatous          |          1                       1                                       |             
      Pigmentation                         |    1     1  1                    1              1           1  1  1      |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |    2                                                                     |             
      Inflammation, Acute                  |    2                       2                    1        1        2      |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Canal, Abscess                       |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +        +     +                       +     +  +  +     +   |             
      Inflammation, Acute                  |                                                          2               |             
      Synechia                             |                            2                                             |             
      Lens, Cataract                       |                      3                             2                 2   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +        +                             +     +  +  +         |             
      Pigmentation                         |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy                          |                                  1              1           1     1     2|             
      Cortex, Mineralization               |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 7| 6| 7| 4| 6| 5| 3| 4| 7| 6| 5| 5| 7| 7| 6| 5| 4| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 6| 4| 6| 1| 4| 4| 6| 6| 7| 5| 6| 4| 4| 7| 0| 4| 4| 4| 7| 3| 4| 4| 4| 8| 4|             
                                           | 3| 4| 3| 5| 3| 3| 3| 1| 4| 0| 3| 3| 5| 4| 4| 9| 9| 5| 4| 0| 4| 9| 3| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.025 G/                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    KG 79 LF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Papilla, Mineralization              |                      1           1                                      1|             
      Renal Tubule, Pigmentation           |    1                             2        2  1  2  1           1  1     1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +     +  +  +     +     +     +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5|                                                           |            |
                             DAY ON TEST   | 4| 4| 4| 3| 7|                                                           |            |
                                           | 4| 4| 9| 9| 4|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8|                                                           |      A     |
    0.025 G/                               | 0| 0| 0| 0| 0|                                                           |      L     |
    KG 79 LF                               | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +                                                               |  61        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +                                                               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +                                                               |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +                                                               |  59        |
      Erosion                              |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +                                                               |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +                                                               |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +                                                               |  57        |
      Hyperplasia, Adenomatous             |                                                                          |      1  2.0|
      Pigmentation                         |    1                                                                     |     25  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +                                                               |  56        |
      Fibrosis                             |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      2  2.5|
      Pigmentation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +                                                               |  56        |
      Pigmentation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +                                                               |  61        |
      Angiectasis                          |                                                                          |      2  1.0|
      Basophilic Focus                     | X  X  X  X                                                               |     45     |
      Clear Cell Focus                     |                                                                          |      3     |
      Degeneration, Cystic                 |                                                                          |      1  1.0|
      Fatty Change, Diffuse                |                                                                          |      6  2.5|
      Fatty Change, Focal                  |                                                                          |     11  1.5|
      Hepatodiaphragmatic Nodule           |                                                                          |      6     |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Granulomatous          | 2     2                                                                  |     24  1.8|
      Mixed Cell Focus                     |                                                                          |      5     |
      Necrosis                             |    1                                                                     |      6  1.5|
      Pigmentation                         | 1  1  1                                                                  |     45  1.3|
      Bile Duct, Hyperplasia               |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +        +                                                               |   9        |
      Fat, Inflammation, Chronic Active    | 2                                                                        |      2  2.0|
      Fat, Necrosis                        |          4                                                               |      7  2.6|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +                                                               |  61        |
      Acinus, Atrophy                      |                                                                          |      1  3.0|
      Acinus, Hyperplasia                  |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +                                                               |  61        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +                                                               |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5|                                                           |            |
                             DAY ON TEST   | 4| 4| 4| 3| 7|                                                           |            |
                                           | 4| 4| 9| 9| 4|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8|                                                           |      A     |
    0.025 G/                               | 0| 0| 0| 0| 0|                                                           |      L     |
    KG 79 LF                               | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Fat, Proliferation                   |       1                                                                  |     15  1.0|
      Polyp Adenomatous, Inflammation      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +                                                               |  60        |
      Acanthosis                           |    2     3                                                               |     20  2.1|
      Hyperkeratosis                       |    2     2                                                               |     23  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +                                                               |  60        |
      Erosion                              |                                                                          |     11  1.4|
      Fibrosis                             |    2  2                                                                  |     39  1.9|
      Hemorrhage                           |                                                                          |      3  1.3|
      Hyperplasia                          |                                                                          |     24  1.3|
      Hyperplasia, Adenomatous             |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      4  1.5|
      Metaplasia                           |    2  1  1                                                               |     36  1.3|
      Mineralization                       |                                                                          |      7  1.9|
      Pigmentation                         |       2                                                                  |     19  1.1|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +                                                               |  61        |
      Cardiomyopathy                       | 2  2  2                                                                  |     23  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +                                                               |  61        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +                                                               |  61        |
      Degeneration, Cystic                 |                                                                          |      1  3.0|
      Degeneration                         |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      2  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Pigmentation, Ceroid                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +                                                               |  60        |
      Hyperplasia                          | 1                                                                        |      8  1.6|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +                                                               |  61        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M                                                               |  53        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +                                                               |  59        |
      Pars Distalis, Angiectasis           |                                                                          |     21  2.1|
      Pars Distalis, Cyst                  |                                                                          |      4     |
      Pars Distalis, Hyperplasia           |                                                                          |     18  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5|                                                           |            |
                             DAY ON TEST   | 4| 4| 4| 3| 7|                                                           |            |
                                           | 4| 4| 9| 9| 4|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8|                                                           |      A     |
    0.025 G/                               | 0| 0| 0| 0| 0|                                                           |      L     |
    KG 79 LF                               | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Intermedia, Cyst                |    X                                                                     |      1     |
      Pars Nervosa, Cyst                   |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +                                                               |  57        |
      C-Cell, Hyperplasia                  | 1                                                                        |     17  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  M                                                               |  55        |
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +                                                               |  61        |
      Cyst                                 |                                                                          |      6     |
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Hyperplasia, Tubular                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +                                                               |  61        |
      Hemorrhage                           |                                                                          |      2  3.0|
      Endometrium, Hyperplasia             |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +                                                               |  61        |
      Pigmentation                         |                                                                          |      8  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +                                                               |  61        |
      Mediastinal, Hemorrhage              |                                                                          |      1  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |       1                                                                  |     21  1.3|
      Mediastinal, Pigmentation            |    1  1                                                                  |     23  1.5|
      Pancreatic, Angiectasis              |                                                                          |      1  3.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |       2                                                                  |      5  2.0|
      Pancreatic, Pigmentation             |       3                                                                  |     10  2.4|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +                                                               |  59        |
      Infiltration Cellular, Histiocyte    |          1                                                               |      6  1.2|
      Pigmentation                         | 2  2  1                                                                  |     34  1.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +                                                               |  61        |
      Depletion Lymphoid                   |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    | 2  2  2  3                                                               |     45  2.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5|                                                           |            |
                             DAY ON TEST   | 4| 4| 4| 3| 7|                                                           |            |
                                           | 4| 4| 9| 9| 4|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8|                                                           |      A     |
    0.025 G/                               | 0| 0| 0| 0| 0|                                                           |      L     |
    KG 79 LF                               | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pigmentation                         | 2  3  2                                                                  |     47  2.1|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +                                                               |  60        |
      Depletion Lymphoid                   |    2                                                                     |      3  1.7|
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     | 2     2  2                                                               |     43  2.1|
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    | 2     2  1                                                               |     28  1.6|
      Pigmentation, Hemosiderin            | 2     2                                                                  |     25  1.8|
      Pigmentation                         | 2  2  2                                                                  |     34  1.9|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +                                                               |  56        |
      Cyst                                 |                                                                          |      1     |
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Pigmentation                         | 1                                                                        |     34  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +                                                               |  56        |
      Galactocele                          |       X                                                                  |     12     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +                                                               |  61        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +                                                               |  61        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +                                                               |  61        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Necrosis                             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +                                                               |  61        |
      Atelectasis                          |          2                                                               |      5  1.8|
      Congestion                           |                                                                          |      4  2.5|
      Edema                                |    3     2                                                               |      5  2.4|
      Hemorrhage                           | 1                                                                        |      7  1.6|
      Infiltration Cellular, Histiocyte    | 2  3  1  2                                                               |     48  1.4|
      Inflammation, Acute                  |                                                                          |      4  1.5|
      Inflammation, Granulomatous          |                                                                          |      3  1.0|
      Pigmentation                         | 1  1     2                                                               |     23  1.2|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +                                                               |  61        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 5|                                                           |            |
                             DAY ON TEST   | 4| 4| 4| 3| 7|                                                           |            |
                                           | 4| 4| 9| 9| 4|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8|                                                           |      A     |
    0.025 G/                               | 0| 0| 0| 0| 0|                                                           |      L     |
    KG 79 LF                               | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Fungus                               |    2                                                                     |      2  2.0|
      Inflammation, Acute                  |    2  1                                                                  |     13  1.6|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +                                                               |  59        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      Canal, Abscess                       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |  11        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Synechia                             |                                                                          |      1  2.0|
      Lens, Cataract                       |                                                                          |      5  2.2|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   8        |
      Pigmentation                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +                                                               |  61        |
      Cyst                                 |                                                                          |      1     |
      Nephropathy                          |       2                                                                  |     26  1.4|
      Cortex, Mineralization               |    1                                                                     |      4  1.5|
      Papilla, Mineralization              | 1                                                                        |     10  1.1|
      Renal Tubule, Pigmentation           | 1     1  1                                                               |     32  1.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +                                                               |  58        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 5| 4| 3| 2| 7| 7| 5| 4| 5| 7| 7| 5| 4| 4| 7| 7| 5| 4| 3|             
                             DAY ON TEST   | 4| 4| 4| 6| 7| 4| 7| 6| 3| 3| 4| 4| 7| 5| 7| 4| 4| 7| 6| 9| 4| 4| 7| 5| 0|             
                                           | 8| 8| 2| 5| 4| 4| 4| 3| 8| 4| 8| 8| 4| 7| 4| 8| 8| 4| 4| 3| 8| 8| 5| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.05 G/K                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G 79 HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  A  +  +|             
      Parasite                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  A  +  +|             
      Pigmentation                         |    1     1     1        1     1  1     2     1                 1        1|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  A  +  +|             
      Pigmentation                         |       1                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  A  +  +|             
      Pigmentation                         |    1                             1           1                          1|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Angiectasis                          | 1                                                                        |             
      Basophilic Focus                     | X  X  X        X              X  X     X     X  X        X  X     X  X   |             
      Clear Cell Focus                     | X              X              X  X           X              X            |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change, Diffuse                |       1  2                             1                          2      |             
      Fatty Change, Focal                  | 1              1                                                         |             
      Hepatodiaphragmatic Nodule           |                                                 X           X            |             
      Inflammation, Granulomatous          | 2  2           1           1  2  1           1  1                    1   |             
      Mixed Cell Focus                     |                                                 X                        |             
      Necrosis                             |                                                                   2      |             
      Pigmentation                         | 1  1  2  1     1           1  2  1     1     1  1           2  1     1  1|             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                               +              +     +   |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
      Fat, Necrosis                        | 3                                               2                    1   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Hyperplasia                  |                                  2           2  1                        |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Fat, Proliferation                   |    3  4  2     4              2  2     1                 3     3  2  2   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Acanthosis                           | 2        2     2        2     1  2                       1     3         |             
      Hyperkeratosis                       |    3     2     2        2        1                             2         |             
      Inflammation, Acute                  |                                        1                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Erosion                              |          2                             1                 2           1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 5| 4| 3| 2| 7| 7| 5| 4| 5| 7| 7| 5| 4| 4| 7| 7| 5| 4| 3|             
                             DAY ON TEST   | 4| 4| 4| 6| 7| 4| 7| 6| 3| 3| 4| 4| 7| 5| 7| 4| 4| 7| 6| 9| 4| 4| 7| 5| 0|             
                                           | 8| 8| 2| 5| 4| 4| 4| 3| 8| 4| 8| 8| 4| 7| 4| 8| 8| 4| 4| 3| 8| 8| 5| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.05 G/K                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G 79 HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             | 2  2  2  2     2        2  1  2  2     2     1  1        2  1  2  2  2   |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |       1        2                 1     1                 2     1     1   |             
      Inflammation, Acute                  |                                                                      2   |             
      Metaplasia                           | 1  1  1  1     2        1  1  2  1     1                 2  1  1  1  1  1|             
      Mineralization                       |                                                                          |             
      Pigmentation                         |    2  2        1              1  1           1           1  1  1         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Cardiomyopathy                       |       2                 1  1                 2  2           2  2         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Hyperplasia                          |                                  2                                       |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Hyperplasia                          |       1                                         1                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +     +        +  +  +  +     +     M  +        +  +  +  M  +  M|             
      Hyperplasia                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |          2                       2           2  2        2        3      |             
      Pars Distalis, Cyst                  |                X                                                         |             
      Pars Distalis, Hyperplasia           | 2              2              2  1                             2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  M|             
      C-Cell, Hyperplasia                  |    1           2              1                 2                        |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                   +      |             
      Hemorrhage                           |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  M|             
      Inflammation, Acute                  |                                                 3                        |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Cyst                                 |                               X                                          |             
      Decidual Reaction                    |                                                                          |             
      Hemorrhage                           |    3                                                                     |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 5| 4| 3| 2| 7| 7| 5| 4| 5| 7| 7| 5| 4| 4| 7| 7| 5| 4| 3|             
                             DAY ON TEST   | 4| 4| 4| 6| 7| 4| 7| 6| 3| 3| 4| 4| 7| 5| 7| 4| 4| 7| 6| 9| 4| 4| 7| 5| 0|             
                                           | 8| 8| 2| 5| 4| 4| 4| 3| 8| 4| 8| 8| 4| 7| 4| 8| 8| 4| 4| 3| 8| 8| 5| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.05 G/K                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G 79 HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                                                          2               |             
      Prolapse                             |                                                          X               |             
      Thrombosis                           |                                                                          |             
      Cervix, Inflammation, Acute          |                                                                          |             
      Endometrium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Pigmentation                         |       1  1     1        1     1  1           1  1                    1  2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Lumbar, Degeneration, Cystic         |                                                                          |             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      | 1  2  2        1        1        2              1        2  2     2     1|             
      Mediastinal, Pigmentation            |    1  1        1        2        2              2           2        1  1|             
      Pancreatic, Angiectasis              |                                                                          |             
      Pancreatic, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |    3           2                                2           2  2  2      |             
      Pancreatic, Pigmentation             |    3           2                                3           3  2     2  2|             
      Renal, Angiectasis                   |                                                                          |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 1  1  2        1              2  2     1                          1      |             
      Pigmentation                         |                         1     2                 2                    1  1|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Infiltration Cellular, Histiocyte    | 3  2  3        2              2  3     3     2  2        3  2     2      |             
      Pigmentation                         | 2  2  3        2        2     3  3     2     2  2           2  2     2  2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Depletion Lymphoid                   |                                                                         2|             
      Hematopoietic Cell Proliferation     | 2  2  2        2        2  2  2  1     2     1  2        3        2  2   |             
      Infiltration Cellular, Histiocyte    | 2  2  2        2              1  2     2     2  1           1            |             
      Inflammation, Granulomatous          |    2                                                                     |             
      Pigmentation, Hemosiderin            | 2  2  2        2        2     2  2           2  2           2           2|             
      Pigmentation                         | 1  2  1        2              1  2           2  2           2            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     +        +  M  +  +     +     +  +        +  +  +  +  +  +|             
      Pigmentation                         | 1  1  1  1     1        1     1  1     1     1  1              1     1   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +     +        +  +  M  +     M     M  +        +  +  +  M  M  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 5| 4| 3| 2| 7| 7| 5| 4| 5| 7| 7| 5| 4| 4| 7| 7| 5| 4| 3|             
                             DAY ON TEST   | 4| 4| 4| 6| 7| 4| 7| 6| 3| 3| 4| 4| 7| 5| 7| 4| 4| 7| 6| 9| 4| 4| 7| 5| 0|             
                                           | 8| 8| 2| 5| 4| 4| 4| 3| 8| 4| 8| 8| 4| 7| 4| 8| 8| 4| 4| 3| 8| 8| 5| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.05 G/K                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G 79 HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Galactocele                          |                                                                          |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Atelectasis                          |                                                 2        2               |             
      Congestion                           |                                                                      1   |             
      Edema                                |                                        2                                3|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1  1  1        1        2  1  2  2     1     1  2        1  1  1        2|             
      Inflammation, Acute                  |                         3                       1        2              2|             
      Inflammation, Granulomatous          |                                  1           2  1                        |             
      Pigmentation                         |    1           1              1  1     1     1  2        2  1  1         |             
      Pigmentation, Cholesterol            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                               1              1                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Fungus                               |                                                                          |             
      Inflammation, Acute                  |       1        2                       2                                 |             
      Submucosa, Glands, Hyperplasia       |                                              2                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Squamous                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +                    +           +                                 |             
      Inflammation, Acute                  |                                                                          |             
      Canal, Abscess                       |       4                                                                  |             
                                            __________________________________________________________________________|             
   Eye                                     |       +  +              +  +                 +  +        +  +            |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Synechia                             |          2              1                                                |             
      Lens, Cataract                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 5| 4| 3| 2| 7| 7| 5| 4| 5| 7| 7| 5| 4| 4| 7| 7| 5| 4| 3|             
                             DAY ON TEST   | 4| 4| 4| 6| 7| 4| 7| 6| 3| 3| 4| 4| 7| 5| 7| 4| 4| 7| 6| 9| 4| 4| 7| 5| 0|             
                                           | 8| 8| 2| 5| 4| 4| 4| 3| 8| 4| 8| 8| 4| 7| 4| 8| 8| 4| 4| 3| 8| 8| 5| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.05 G/K                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G 79 HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Retina, Atrophy                      |          2                                   2                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +  +              +                       +        +  +            |             
      Pigmentation                         |       3  2                                                               |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
      Nephropathy                          | 1  1  1        2              2  1           2  3           1  1         |             
      Cortex, Mineralization               |                                                                          |             
      Papilla, Mineralization              |                         1                                            1   |             
      Renal Tubule, Hyperplasia            |                                                                      1   |             
      Renal Tubule, Pigmentation           | 1  1  2  1     1                 1     1                 1  1  2  1  1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +        +  +  +  +     +     +  +        +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 6| 2| 7| 7| 7| 6| 4| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 4| 7| 7| 6| 3|             
                             DAY ON TEST   | 6| 6| 4| 1| 3| 4| 4| 4| 6| 9| 4| 8| 7| 5| 2| 4| 4| 4| 7| 7| 6| 4| 4| 9| 4|             
                                           | 3| 4| 8| 7| 2| 3| 9| 9| 5| 3| 4| 3| 3| 3| 1| 4| 9| 9| 4| 4| 4| 8| 8| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    0.05 G/K                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    G 79 HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Parasite                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +        +  +  +  +|             
      Pigmentation                         |             1  1     1              1        1  1     1           1  1  1|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +        +  +  +  +|             
      Pigmentation                         |                                     1                                1   |             
                                            __________________________________________________________________________|             
   Liver                                   |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Abscess                              |                            3                                             |             
      Angiectasis                          |                                                       2                  |             
      Basophilic Focus                     |       X  X  X  X  X  X  X     X  X  X  X  X  X  X  X           X  X  X  X|             
      Clear Cell Focus                     |                                              X  X                        |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change, Diffuse                |                                     1     2                       2      |             
      Fatty Change, Focal                  |          1        1           1  2                    2        1     2   |             
      Hepatodiaphragmatic Nodule           |                         X                             X           X      |             
      Inflammation, Granulomatous          |       2           1  2        1     1        1  2  2           1  1  1  1|             
      Mixed Cell Focus                     |       X                                                                  |             
      Necrosis                             |          1              1     1                       1                  |             
      Pigmentation                         |       2     1  1  2  2  2     2  2  1  1     1  1  2  1        1  1  1  1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                            +     +   |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
      Fat, Necrosis                        |                   4                                            3         |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +        +  +  +  +|             
      Fibrosis                             |                                  2                                       |             
      Inflammation, Chronic Active         |                                  3                                       |             
      Acinus, Hyperplasia                  |          2                                      2              2  2      |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Inflammation, Chronic Active         |                               2                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Fat, Proliferation                   |       3        4  4  3  3  2  1  4  3     2  2     3           2  2  1   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Acanthosis                           |       2           2  2  2     2  2  2           3                 1      |             
      Hyperkeratosis                       |                   2     2     2  2  2        2  2                 3      |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Erosion                              |                            1     1                                   1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 6| 2| 7| 7| 7| 6| 4| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 4| 7| 7| 6| 3|             
                             DAY ON TEST   | 6| 6| 4| 1| 3| 4| 4| 4| 6| 9| 4| 8| 7| 5| 2| 4| 4| 4| 7| 7| 6| 4| 4| 9| 4|             
                                           | 3| 4| 8| 7| 2| 3| 9| 9| 5| 3| 4| 3| 3| 3| 1| 4| 9| 9| 4| 4| 4| 8| 8| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    0.05 G/K                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    G 79 HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |       2  1     3  2  2  2  2  2     2  2  3  2                 2  2  2   |             
      Hemorrhage                           |                                  1                                       |             
      Hyperplasia                          |                      1  1  2  2  1        2  2                       2   |             
      Inflammation, Acute                  |                            1              1                              |             
      Metaplasia                           |       1        2  1  1  1  1  1  2  2     1  1  1  1           1  1  1  1|             
      Mineralization                       |                                                                      1   |             
      Pigmentation                         |       1                    1  1  1              1                 1  1  1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Cardiomyopathy                       |                2  2                    2           2           2  2      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Hyperplasia                          |                                                       1           1      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Pars Distalis, Angiectasis           |                2        3  2        3  2  2  2  2     2        2  2  3   |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |          2  1           3  2           2  2  2        2        2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      C-Cell, Hyperplasia                  |                               1  1  2        2  1                        |             
      Follicular Cell, Hyperplasia         |                                  1                                   2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |       +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Cyst                                 |                                                                          |             
      Decidual Reaction                    |                                                                          |             
      Hemorrhage                           |                   3           4                                          |             
      Inflammation, Acute                  |                   4                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 6| 2| 7| 7| 7| 6| 4| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 4| 7| 7| 6| 3|             
                             DAY ON TEST   | 6| 6| 4| 1| 3| 4| 4| 4| 6| 9| 4| 8| 7| 5| 2| 4| 4| 4| 7| 7| 6| 4| 4| 9| 4|             
                                           | 3| 4| 8| 7| 2| 3| 9| 9| 5| 3| 4| 3| 3| 3| 1| 4| 9| 9| 4| 4| 4| 8| 8| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    0.05 G/K                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    G 79 HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                                                                          |             
      Prolapse                             |                                                                          |             
      Thrombosis                           |                               3                                          |             
      Cervix, Inflammation, Acute          |                                           2                              |             
      Endometrium, Hyperplasia             |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +        +  +  +  +|             
      Pigmentation                         |                      1                       1     1           1     1   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Lumbar, Degeneration, Cystic         |                                                                          |             
      Mediastinal, Congestion              |             2                                                            |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |       2           2     2        2  1        1     1           1        1|             
      Mediastinal, Pigmentation            |       1           1     2        1  1        1     1           1        1|             
      Pancreatic, Angiectasis              |                         2                                                |             
      Pancreatic, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                2  1     2                                      2  2      |             
      Pancreatic, Pigmentation             |                2  1     2                                      3  3      |             
      Renal, Angiectasis                   |                                                                          |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                   1  1     1        2  1           2           1         |             
      Pigmentation                         |       2           1  1        1  1  2  1           2           1     1   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Angiectasis                          |                         2                                         3      |             
      Infiltration Cellular, Histiocyte    |       2        2  2  2  2  2  2  2  2  2  2  2  3  3           2     2   |             
      Pigmentation                         |       2     2  2  2  2  2  2  2  2  3  2  2  2  3  3           2  1  2  2|             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Angiectasis                          |                                  2                    2                  |             
      Depletion Lymphoid                   |                                                                   2      |             
      Hematopoietic Cell Proliferation     |       2     2     3  1  2  2  3  3        2  2  2  3  2        1  3  2  2|             
      Infiltration Cellular, Histiocyte    |       2              1  2  2        2  2  2  1  1  1           1     2   |             
      Inflammation, Granulomatous          |                                                                          |             
      Pigmentation, Hemosiderin            |       2     1        2  2     2     2  2     2  2  2  1        2     2  2|             
      Pigmentation                         |       2              2  2     1     2  2     2  2  2  1        2     2   |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Pigmentation                         |       1        1  1  1  1     1  1  1  1     1  1  1           1  1  1  1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 6| 2| 7| 7| 7| 6| 4| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 4| 7| 7| 6| 3|             
                             DAY ON TEST   | 6| 6| 4| 1| 3| 4| 4| 4| 6| 9| 4| 8| 7| 5| 2| 4| 4| 4| 7| 7| 6| 4| 4| 9| 4|             
                                           | 3| 4| 8| 7| 2| 3| 9| 9| 5| 3| 4| 3| 3| 3| 1| 4| 9| 9| 4| 4| 4| 8| 8| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    0.05 G/K                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    G 79 HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Galactocele                          |                         X                       X                 X  X   |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Hyperplasia                          |                                           2                              |             
      Necrosis                             |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Atelectasis                          |                                                                         2|             
      Congestion                           |                                                                          |             
      Edema                                |             2                    2                                      2|             
      Hemorrhage                           |                3                 1                                       |             
      Infiltration Cellular, Histiocyte    |       2  1  2  2  1  1  1     2     1     1  1  1     1        1  1  2  2|             
      Inflammation, Acute                  |                               3  3              2              1         |             
      Inflammation, Granulomatous          |       2     1                                                           1|             
      Pigmentation                         |                1  1  1        1     1  1     1  1              1  1     2|             
      Pigmentation, Cholesterol            |                                                                1         |             
      Alveolar Epithelium, Hyperplasia     |          2        2                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Fungus                               |                                                                          |             
      Inflammation, Acute                  |                1                 3     2           2  2              1   |             
      Submucosa, Glands, Hyperplasia       |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Erosion                              |                                  1                                       |             
      Inflammation, Acute                  |                                  2                                       |             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Squamous                 |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                               +           +                              |             
      Inflammation, Acute                  |                                           3                              |             
      Canal, Abscess                       |                               4                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +              +  +  +                                +   |             
      Hemorrhage                           |                                     3                                    |             
      Inflammation, Acute                  |                               4                                          |             
      Synechia                             |                                  2                                       |             
      Lens, Cataract                       |                                     3                                2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 6| 2| 7| 7| 7| 6| 4| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 4| 7| 7| 6| 3|             
                             DAY ON TEST   | 6| 6| 4| 1| 3| 4| 4| 4| 6| 9| 4| 8| 7| 5| 2| 4| 4| 4| 7| 7| 6| 4| 4| 9| 4|             
                                           | 3| 4| 8| 7| 2| 3| 9| 9| 5| 3| 4| 3| 3| 3| 1| 4| 9| 9| 4| 4| 4| 8| 8| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    0.05 G/K                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    G 79 HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +              +  +                                   +   |             
      Pigmentation                         |                               2  2                                       |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
      Nephropathy                          |       2        1                    1  2  1  2  2  1           1  3  3   |             
      Cortex, Mineralization               |                                  1           1                           |             
      Papilla, Mineralization              |                               1                       1                  |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Pigmentation           |       2        2  1     2  1  1     1     1  1  1  2  2        2     1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 4| 7| 5| 5| 6| 6| 6| 4| 4| 4| 7| 7| 7| 7| 7| 7| 5| 4| 4|             
                             DAY ON TEST   | 4| 4| 4| 4| 9| 4| 6| 4| 7| 7| 9| 4| 3| 6| 1| 6| 4| 4| 4| 4| 4| 4| 7| 8| 7|             
                                           | 3| 9| 4| 3| 6| 9| 4| 3| 4| 4| 4| 3| 9| 4| 5| 4| 9| 9| 8| 4| 8| 3| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.05 G/K                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G 79 HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Parasite                             |                                                                         1|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  A|             
      Pigmentation                         | 1  1  1        1     1        1  1              1  1  1  1  1  1         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  M  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  A|             
      Pigmentation                         |    1  1                          1                                       |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Abscess                              |                                                                          |             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X  X  X  X  X        X        X  X  X           X  X  X  X  X  X     X   |             
      Clear Cell Focus                     | X                                                        X               |             
      Eosinophilic Focus                   |    X                 X                                                   |             
      Fatty Change, Diffuse                |                2              2  2                                       |             
      Fatty Change, Focal                  |                                     2              1  1     1            |             
      Hepatodiaphragmatic Nodule           |    X  X              X           X                 X                     |             
      Inflammation, Granulomatous          | 1  1  1  2     1     1        1  2                 1     1  1  2         |             
      Mixed Cell Focus                     |    X                                                                     |             
      Necrosis                             |             1        1                                                   |             
      Pigmentation                         | 1  1  1  2     1     1        1  2        1     1  2  1  1  1  1         |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +  +                                                     +         |             
      Fat, Inflammation, Chronic Active    |          2                                                     2         |             
      Fat, Necrosis                        |       3                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Hyperplasia                  |                                                                2         |             
                                            __________________________________________________________________________|             
   Pharynx                                 |       +                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Fat, Proliferation                   | 3  3  2  3     4              1     1     3     2  3  3  3  2  2         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Acanthosis                           |    2           2     2           2              2  2  2        2     1   |             
      Hyperkeratosis                       |    2           2                 1                 2           2     1   |             
      Inflammation, Acute                  |                2                    2     2                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Erosion                              |                1                 1        1                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 4| 7| 5| 5| 6| 6| 6| 4| 4| 4| 7| 7| 7| 7| 7| 7| 5| 4| 4|             
                             DAY ON TEST   | 4| 4| 4| 4| 9| 4| 6| 4| 7| 7| 9| 4| 3| 6| 1| 6| 4| 4| 4| 4| 4| 4| 7| 8| 7|             
                                           | 3| 9| 4| 3| 6| 9| 4| 3| 4| 4| 4| 3| 9| 4| 5| 4| 9| 9| 8| 4| 8| 3| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.05 G/K                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G 79 HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             | 2  2  2  2  1  2     1        1     1     2     2  2  1  2  2  2     2  1|             
      Hemorrhage                           |                                           1                              |             
      Hyperplasia                          |          1     2                 1        1        1     1           2   |             
      Inflammation, Acute                  |                                     1                                    |             
      Metaplasia                           | 2  1  1  2  1  2     1        1     1     1     2  1  1  2  2  1     2   |             
      Mineralization                       | 1                                                                        |             
      Pigmentation                         | 1                    1        1  1                       1  1  1         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Cardiomyopathy                       |          2     2     2        2           1           2  2     2     2   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Hyperplasia                          |                                                                          |             
      Necrosis                             |                                           2                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +     +        +  +  +     +     +  +  M  +  +  +     +  +|             
      Hyperplasia                          |                      1                          2                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Pars Distalis, Angiectasis           |       2                       2  3  3                       3            |             
      Pars Distalis, Cyst                  |                                                    X                     |             
      Pars Distalis, Hyperplasia           | 1  2     2  1        2                             2  2  1  2  2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      C-Cell, Hyperplasia                  |          1           1           2  2                                    |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  M  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Cyst                                 |                                                                X         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Cyst                                 |                                                                      X   |             
      Decidual Reaction                    |                                                                      1   |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 4| 7| 5| 5| 6| 6| 6| 4| 4| 4| 7| 7| 7| 7| 7| 7| 5| 4| 4|             
                             DAY ON TEST   | 4| 4| 4| 4| 9| 4| 6| 4| 7| 7| 9| 4| 3| 6| 1| 6| 4| 4| 4| 4| 4| 4| 7| 8| 7|             
                                           | 3| 9| 4| 3| 6| 9| 4| 3| 4| 4| 4| 3| 9| 4| 5| 4| 9| 9| 8| 4| 8| 3| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.05 G/K                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G 79 HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                                                                          |             
      Prolapse                             |                                                                          |             
      Thrombosis                           |                                                                          |             
      Cervix, Inflammation, Acute          |                                                    3                     |             
      Endometrium, Hyperplasia             |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Pigmentation                         | 2  1  1  1           1           1                 1  1     1  1         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Lumbar, Degeneration, Cystic         |                                                                      2   |             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                  1        2        2           2     2  2|             
      Mediastinal, Pigmentation            |                                  1        1        2           2     1   |             
      Pancreatic, Angiectasis              |                                                                          |             
      Pancreatic, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                      2   |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |       2  2           2                             3        3        2   |             
      Pancreatic, Pigmentation             |       3  3           2                             3        3  2         |             
      Renal, Angiectasis                   |                                                                      2   |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                                                      2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Infiltration Cellular, Histiocyte    | 2  1        1        1        1     1     1                              |             
      Pigmentation                         | 2  1  2  1           2        2  1                       1  1  1         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Angiectasis                          |                                                                          |             
      Infiltration Cellular, Histiocyte    | 2  2  2  2  3        2        2  1  3     2     2  2  2  2  1  2     2  2|             
      Pigmentation                         | 2  2  3  2           3        3  1  2           2  2  2  2  2  2     2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Angiectasis                          |                                                             2            |             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     |    2  2  2  2                 2  2  2              2  2     2        3   |             
      Infiltration Cellular, Histiocyte    | 2  2  2  2                    2  2  2     3        2     1     2        3|             
      Inflammation, Granulomatous          |                                                                          |             
      Pigmentation, Hemosiderin            | 2  2  2  2                    2  2                 2     2  2  2         |             
      Pigmentation                         | 2  2  2  2                    2  2        2        2     2  1  2         |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Pigmentation                         |    1  1  1     1     1        1  1                 1  1  2     2         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M     +        +  +  +     +     +  +  +  M  +  M     M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 4| 7| 5| 5| 6| 6| 6| 4| 4| 4| 7| 7| 7| 7| 7| 7| 5| 4| 4|             
                             DAY ON TEST   | 4| 4| 4| 4| 9| 4| 6| 4| 7| 7| 9| 4| 3| 6| 1| 6| 4| 4| 4| 4| 4| 4| 7| 8| 7|             
                                           | 3| 9| 4| 3| 6| 9| 4| 3| 4| 4| 4| 3| 9| 4| 5| 4| 9| 9| 8| 4| 8| 3| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.05 G/K                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G 79 HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Galactocele                          |    X                 X        X                                          |             
      Acinus, Hyperplasia                  |                                  2                                       |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  M  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Hyperplasia                          |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Atelectasis                          |                      2              2                                    |             
      Congestion                           |                                           3                              |             
      Edema                                |                                                                          |             
      Hemorrhage                           |                               1                                          |             
      Infiltration Cellular, Histiocyte    | 1  1  2  2  1  1     2        1  1                 1     2  1  1         |             
      Inflammation, Acute                  |                                                          1               |             
      Inflammation, Granulomatous          |                      1                                                   |             
      Pigmentation                         | 1  1  1  1     1     1        1  1  2              1     1  1  1         |             
      Pigmentation, Cholesterol            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Fungus                               |                               2                                          |             
      Inflammation, Acute                  |       2                       2  2        3        2        3            |             
      Submucosa, Glands, Hyperplasia       |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                          2               |             
      Metaplasia, Squamous                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                     +                                    |             
      Inflammation, Acute                  |                                                                          |             
      Canal, Abscess                       |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                    +                    +  +        +   |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Synechia                             |                                                                          |             
      Lens, Cataract                       |                2                                         2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 4| 7| 5| 5| 6| 6| 6| 4| 4| 4| 7| 7| 7| 7| 7| 7| 5| 4| 4|             
                             DAY ON TEST   | 4| 4| 4| 4| 9| 4| 6| 4| 7| 7| 9| 4| 3| 6| 1| 6| 4| 4| 4| 4| 4| 4| 7| 8| 7|             
                                           | 3| 9| 4| 3| 6| 9| 4| 3| 4| 4| 4| 3| 9| 4| 5| 4| 9| 9| 8| 4| 8| 3| 4| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.05 G/K                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    G 79 HF                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                    +                    +  +            |             
      Pigmentation                         |                                                          1               |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
      Nephropathy                          | 2  1  2  1     1     1        1  1  2              3  1  2  1  1         |             
      Cortex, Mineralization               |                                                                          |             
      Papilla, Mineralization              |                               1  1                                       |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Pigmentation           | 2  2  1  2     2     2        1  1  2     1           1  1  1  2         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +     +        +  +  +     +     +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 4| 3| 2|                                                           |            |
                             DAY ON TEST   | 7| 6| 6| 4| 4|                                                           |            |
                                           | 4| 4| 3| 4| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9|                                                           |      A     |
    0.05 G/K                               | 6| 6| 6| 6| 6|                                                           |      L     |
    G 79 HF                                | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +  +                                                            |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +  +                                                            |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +  +                                                            |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +  +                                                            |  59        |
      Parasite                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +  +                                                            |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |          +  +                                                            |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +  +                                                            |  56        |
      Pigmentation                         |          1                                                               |     34  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +  +                                                            |  58        |
      Pigmentation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +  +                                                            |  56        |
      Pigmentation                         |                                                                          |      9  1.0|
                                            __________________________________________________________________________|____________|
   Liver                                   |          +  +                                                            |  60        |
      Abscess                              |                                                                          |      1  3.0|
      Angiectasis                          |                                                                          |      2  1.5|
      Basophilic Focus                     |                                                                          |     48     |
      Clear Cell Focus                     |                                                                          |     10     |
      Eosinophilic Focus                   |                                                                          |      2     |
      Fatty Change, Diffuse                |                                                                          |     10  1.7|
      Fatty Change, Focal                  |          1                                                               |     14  1.3|
      Hepatodiaphragmatic Nodule           |                                                                          |     10     |
      Inflammation, Granulomatous          |                                                                          |     33  1.3|
      Mixed Cell Focus                     |                                                                          |      3     |
      Necrosis                             |                                                                          |      7  1.1|
      Pigmentation                         |          1  1                                                            |     50  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |  10        |
      Fat, Inflammation, Chronic Active    |                                                                          |      2  2.0|
      Fat, Necrosis                        |                                                                          |      6  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                |          +  +                                                            |  59        |
      Fibrosis                             |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Acinus, Hyperplasia                  |                                                                          |      8  1.9|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +  +                                                            |  60        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |          +  +                                                            |  60        |
      Fat, Proliferation                   |          2                                                               |     41  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +  +                                                            |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 4| 3| 2|                                                           |            |
                             DAY ON TEST   | 7| 6| 6| 4| 4|                                                           |            |
                                           | 4| 4| 3| 4| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9|                                                           |      A     |
    0.05 G/K                               | 6| 6| 6| 6| 6|                                                           |      L     |
    G 79 HF                                | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Acanthosis                           |          1                                                               |     27  1.9|
      Hyperkeratosis                       |          2                                                               |     21  2.0|
      Inflammation, Acute                  |                                                                          |      4  1.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +  +                                                            |  60        |
      Erosion                              |                                                                          |     10  1.2|
      Fibrosis                             |          2                                                               |     51  1.8|
      Hemorrhage                           |                                                                          |      2  1.0|
      Hyperplasia                          |          1                                                               |     23  1.4|
      Inflammation, Acute                  |          2                                                               |      5  1.4|
      Metaplasia                           |          1                                                               |     51  1.3|
      Mineralization                       |                                                                          |      2  1.0|
      Pigmentation                         |                                                                          |     24  1.1|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +  +                                                            |  60        |
      Cardiomyopathy                       |             2                                                            |     23  1.9|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |          +  +                                                            |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |          +  +                                                            |  60        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |          +  +                                                            |  59        |
      Hyperplasia                          |                                                                          |      6  1.2|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +  +                                                            |  59        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          M  M                                                            |  51        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          +  +                                                            |  60        |
      Pars Distalis, Angiectasis           |                                                                          |     23  2.3|
      Pars Distalis, Cyst                  |                                                                          |      2     |
      Pars Distalis, Hyperplasia           |                                                                          |     24  1.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +  +                                                            |  59        |
      C-Cell, Hyperplasia                  |                                                                          |     13  1.5|
      Follicular Cell, Hyperplasia         |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 4| 3| 2|                                                           |            |
                             DAY ON TEST   | 7| 6| 6| 4| 4|                                                           |            |
                                           | 4| 4| 3| 4| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9|                                                           |      A     |
    0.05 G/K                               | 6| 6| 6| 6| 6|                                                           |      L     |
    G 79 HF                                | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |          +  +                                                            |  56        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |          +  +                                                            |  60        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  |          +  +                                                            |  60        |
      Cyst                                 |                                                                          |      2     |
      Decidual Reaction                    |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      3  3.3|
      Inflammation, Acute                  |                                                                          |      2  3.0|
      Necrosis                             |                                                                          |      1  2.0|
      Prolapse                             |                                                                          |      1     |
      Thrombosis                           |                                                                          |      1  3.0|
      Cervix, Inflammation, Acute          |                                                                          |      2  2.5|
      Endometrium, Hyperplasia             |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +  +                                                            |  59        |
      Pigmentation                         |          1                                                               |     26  1.1|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +  +                                                            |  60        |
      Lumbar, Degeneration, Cystic         |                                                                          |      1  2.0|
      Mediastinal, Congestion              |                                                                          |      1  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |          1                                                               |     27  1.6|
      Mediastinal, Pigmentation            |          1  1                                                            |     25  1.3|
      Pancreatic, Angiectasis              |                                                                          |      1  2.0|
      Pancreatic, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                                          |      1  2.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |     17  2.1|
      Pancreatic, Pigmentation             |                                                                          |     18  2.4|
      Renal, Angiectasis                   |                                                                          |      1  2.0|
      Renal, Infiltration Cellular,        |                                                                          |            |
          Histiocyte                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +  +                                                            |  60        |
      Infiltration Cellular, Histiocyte    |                                                                          |     22  1.3|
      Pigmentation                         |          1                                                               |     26  1.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +  +                                                            |  60        |
      Angiectasis                          |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 4| 3| 2|                                                           |            |
                             DAY ON TEST   | 7| 6| 6| 4| 4|                                                           |            |
                                           | 4| 4| 3| 4| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9|                                                           |      A     |
    0.05 G/K                               | 6| 6| 6| 6| 6|                                                           |      L     |
    G 79 HF                                | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Infiltration Cellular, Histiocyte    |             2                                                            |     47  2.1|
      Pigmentation                         |          2                                                               |     49  2.1|
                                            __________________________________________________________________________|____________|
   Spleen                                  |          +  +                                                            |  60        |
      Angiectasis                          |                                                                          |      3  2.0|
      Depletion Lymphoid                   |                                                                          |      2  2.0|
      Hematopoietic Cell Proliferation     |             2                                                            |     43  2.1|
      Infiltration Cellular, Histiocyte    |                                                                          |     34  1.8|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |             2                                                            |     36  1.9|
      Pigmentation                         |             1                                                            |     33  1.8|
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +  +                                                            |  58        |
      Pigmentation                         |          1                                                               |     41  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          +  +                                                            |  49        |
      Galactocele                          |                                                                          |      7     |
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |          +  +                                                            |  58        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +  +                                                            |  60        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +  +                                                            |  60        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |          +  +                                                            |  60        |
      Atelectasis                          |                                                                          |      5  2.0|
      Congestion                           |             3                                                            |      3  2.3|
      Edema                                |             2                                                            |      6  2.2|
      Hemorrhage                           |                                                                          |      3  1.7|
      Infiltration Cellular, Histiocyte    |             2                                                            |     46  1.3|
      Inflammation, Acute                  |                                                                          |      9  2.0|
      Inflammation, Granulomatous          |             2                                                            |      8  1.4|
      Pigmentation                         |             2                                                            |     35  1.1|
      Pigmentation, Cholesterol            |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 4| 3| 2|                                                           |            |
                             DAY ON TEST   | 7| 6| 6| 4| 4|                                                           |            |
                                           | 4| 4| 3| 4| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9|                                                           |      A     |
    0.05 G/K                               | 6| 6| 6| 6| 6|                                                           |      L     |
    G 79 HF                                | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      4  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    |          +  +                                                            |  60        |
      Fungus                               |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |     15  2.0|
      Submucosa, Glands, Hyperplasia       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +  +                                                            |  60        |
      Erosion                              |                                                                          |      1  1.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Metaplasia, Squamous                 |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   6        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Canal, Abscess                       |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |  18        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Synechia                             |                                                                          |      3  1.7|
      Lens, Cataract                       |                                                                          |      4  2.3|
      Retina, Atrophy                      |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |  14        |
      Pigmentation                         |                                                                          |      5  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |          +  +                                                            |  60        |
      Nephropathy                          |                                                                          |     35  1.5|
      Cortex, Mineralization               |                                                                          |      2  1.0|
      Papilla, Mineralization              |                                                                          |      6  1.0|
      Renal Tubule, Hyperplasia            |                                                                          |      1  1.0|
      Renal Tubule, Pigmentation           |                                                                          |     40  1.4|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +  +                                                            |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 5| 7| 7| 7| 7| 5| 7| 4| 6| 4| 5| 7| 7| 7| 5| 5| 4| 7| 7| 6| 5|             
                             DAY ON TEST   | 4| 4| 2| 5| 5| 4| 4| 3| 3| 7| 3| 5| 5| 5| 7| 4| 4| 4| 7| 7| 5| 4| 1| 4| 7|             
                                           | 4| 4| 2| 8| 0| 5| 5| 9| 8| 6| 8| 8| 9| 7| 8| 5| 5| 5| 7| 6| 7| 4| 7| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    79VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +  +  +     +     A     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     A  +  +  +  +     +     A     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +     +     A     +  +  +  +  +        +  +  +   |             
      Parasite                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     A  +  +  +  +     +     A     +  +  +  +  +        +  +  +   |             
      Parasite                             |                                              1                 2         |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     A  +  +  +  +     +     A     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     A  +  +  +  +     +     A     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Basophilic Focus                     | X  X  X              X  X     X              X  X  X  X        X         |             
      Clear Cell Focus                     |    X                 X        X              X                           |             
      Cyst                                 |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change, Diffuse                |                                                                      2   |             
      Fatty Change, Focal                  |             3                                         1        1  1      |             
      Fibrosis                             |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Infarct                              |                                                                          |             
      Mixed Cell Focus                     | X                                                                        |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                                                                          |             
      Bile Duct, Hyperplasia               | 2  2  2        2  3  2        2           2        2  2           2  2   |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +                                                                     |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
      Fat, Inflammation, Chronic Active    | 1                                                                        |             
      Fat, Mineralization                  |                                                                          |             
      Fat, Necrosis                        |    2                                                                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  M  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Hyperplasia                          |                                                                          |             
      Acinus, Focal Cellular Change        |                                                                          |             
      Acinus, Hyperplasia                  |       3              2                                                   |             
      Artery, Inflammation, Chronic Active |                                              3  1                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Acanthosis                           |                3                                      2                  |             
      Hemorrhage                           |                                                                          |             
      Hyperkeratosis                       |                2                                      2                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 5| 7| 7| 7| 7| 5| 7| 4| 6| 4| 5| 7| 7| 7| 5| 5| 4| 7| 7| 6| 5|             
                             DAY ON TEST   | 4| 4| 2| 5| 5| 4| 4| 3| 3| 7| 3| 5| 5| 5| 7| 4| 4| 4| 7| 7| 5| 4| 1| 4| 7|             
                                           | 4| 4| 2| 8| 0| 5| 5| 9| 8| 6| 8| 8| 9| 7| 8| 5| 5| 5| 7| 6| 7| 4| 7| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    79VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     A  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Erosion                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Cardiomyopathy                       | 2  2  2     2  2  2     3     2     3     2  2  3  2           2     2   |             
      Artery, Necrosis, Fibrinoid          |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Hyperplasia                          |                2                                                         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Hyperplasia                          |    2           2  1                       2     2                 1  1   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  M  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +  +     +     +     +  +  +  +  M        +  M  +   |             
      Cyst                                 |                                                                          |             
      Pars Distalis, Angiectasis           | 2                       2                       2              1     3   |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |       2        3     2                             1           1         |             
      Pars Distalis, Pigmentation          |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      C-Cell, Hyperplasia                  |                1        1                                                |             
      Follicular Cell, Cyst                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Spermatocele                         |                                                                X         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Abscess                              |                                                                          |             
      Epithelium, Hyperplasia              |       1        2                             2                           |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Interstitial Cell, Hyperplasia       |                1                             1  2     2        2  2      |             
      Seminiferous Tubule, Atrophy         |    2           3  2  2        2              2  2              2  2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 5| 7| 7| 7| 7| 5| 7| 4| 6| 4| 5| 7| 7| 7| 5| 5| 4| 7| 7| 6| 5|             
                             DAY ON TEST   | 4| 4| 2| 5| 5| 4| 4| 3| 3| 7| 3| 5| 5| 5| 7| 4| 4| 4| 7| 7| 5| 4| 1| 4| 7|             
                                           | 4| 4| 2| 8| 0| 5| 5| 9| 8| 6| 8| 8| 9| 7| 8| 5| 5| 5| 7| 6| 7| 4| 7| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    79VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Mediastinal, Degeneration, Cystic    |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |       1                 1                          1                     |             
      Mediastinal, Pigmentation            |       1                 1                          1                     |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Degeneration, Cystic                 |                                                 2  2                     |             
      Degeneration                         |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                                 2                        |             
      Infiltration Cellular, Histiocyte    | 1                                                     2                  |             
      Pigmentation                         | 1                    1                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Infiltration Cellular, Mast Cell     |                                                                          |             
      Infiltration Cellular, Histiocyte    |    1        2        2  1     1           2        2  1        2         |             
      Pigmentation                         |    1                 2  1     1                       1        2         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis                             |                                                                   2      |             
      Hematopoietic Cell Proliferation     |       2                 2                    2  2  2           2         |             
      Hemorrhage                           |       2                                                                  |             
      Infiltration Cellular, Histiocyte    | 1  1  2              1        1                    2  2        2         |             
      Pigmentation, Hemosiderin            | 2  2  2              2  2     1                    2  1        2         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  M  +  +  +     +     +     +  +  M  +  +        +  +  +   |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +  +  M  +  +     +     M     +  +  +  +  +        +  +  +   |             
      Galactocele                          |                                                                      X   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperplasia, Squamous                |                                                    2                     |             
      Inflammation, Chronic Active         |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 5| 7| 7| 7| 7| 5| 7| 4| 6| 4| 5| 7| 7| 7| 5| 5| 4| 7| 7| 6| 5|             
                             DAY ON TEST   | 4| 4| 2| 5| 5| 4| 4| 3| 3| 7| 3| 5| 5| 5| 7| 4| 4| 4| 7| 7| 5| 4| 1| 4| 7|             
                                           | 4| 4| 2| 8| 0| 5| 5| 9| 8| 6| 8| 8| 9| 7| 8| 5| 5| 5| 7| 6| 7| 4| 7| 7| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    79VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Congestion                           |             3                       4                                    |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 2                                                              1     1   |             
      Inflammation, Acute                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Fungus                               |                                                                          |             
      Inflammation, Acute                  |                      1                                                   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                           +                              |             
                                            __________________________________________________________________________|             
   Eye                                     |                                     +                                    |             
      Lens, Cataract                       |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                     +                                    |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                 +  +                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
      Nephropathy                          | 3  2  2        2  2  2  3     1           1  2  2  2  2        2  2  2   |             
      Artery, Necrosis, Fibrinoid          |                      2                                                   |             
      Cortex, Mineralization               |                                                                          |             
      Papilla, Mineralization              |                                                 1                        |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Pigmentation           |                      1        1                 1  1  1              2   |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +  +     +     +     +  +  +  +  +        +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 4| 7| 7| 6| 5| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 4| 4| 4| 3| 7| 5| 4| 4| 0| 7| 4| 4| 3| 7| 7| 4| 4| 3| 7| 7| 4| 4| 5| 3| 5|             
                                           | 4| 4| 4| 9| 6| 8| 5| 5| 5| 6| 6| 6| 8| 9| 6| 6| 6| 8| 6| 6| 5| 4| 8| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    79VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Parasite                             | 1  1                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Parasite                             |                               2                 X                        |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Basophilic Focus                     | X  X  X  X           X  X        X  X        X  X  X        X  X     X   |             
      Clear Cell Focus                     |       X  X                          X              X        X  X     X   |             
      Cyst                                 |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                               X                 X  X                     |             
      Fatty Change, Diffuse                |                         2              3                                 |             
      Fatty Change, Focal                  |                                                             1  1         |             
      Fibrosis                             |                                                                          |             
      Hepatodiaphragmatic Nodule           |    X  X                                                                  |             
      Infarct                              |                   4                                                      |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                                                                          |             
      Bile Duct, Hyperplasia               | 2                 2  2        2  2  2                          2     2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                                    |             
      Artery, Necrosis, Fibrinoid          |                                     2                                    |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
      Fat, Mineralization                  |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Hyperplasia                          |                                                                          |             
      Acinus, Focal Cellular Change        |                                                                          |             
      Acinus, Hyperplasia                  |       2  3        2  3                          2  2           2     2   |             
      Artery, Inflammation, Chronic Active |                                  1                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +        +  +  +     +  +  M  +     +  +  +        +  +     +   |             
      Acanthosis                           |                         2                                                |             
      Hemorrhage                           |                                                                          |             
      Hyperkeratosis                       |                         2                                                |             
      Inflammation, Chronic Active         |                         3                                                |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 4| 7| 7| 6| 5| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 4| 4| 4| 3| 7| 5| 4| 4| 0| 7| 4| 4| 3| 7| 7| 4| 4| 3| 7| 7| 4| 4| 5| 3| 5|             
                                           | 4| 4| 4| 9| 6| 8| 5| 5| 5| 6| 6| 6| 8| 9| 6| 6| 6| 8| 6| 6| 5| 4| 8| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    79VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Erosion                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Cardiomyopathy                       | 2  2  2  2              2     2  2  2  2     2  2  2        2  2     2   |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Hyperplasia                          | 1  2  1           1     2     2     1                                    |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Hyperplasia                          |                                                                2         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +        +  +  +     +  M  +  +     +  +  +        +  +     +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +        +  +  +     +  +  M  +     +  +  +        +  +     M   |             
      Cyst                                 |       X                                                                  |             
      Pars Distalis, Angiectasis           |    3                                   3           2        3            |             
      Pars Distalis, Cyst                  |                                                 X                        |             
      Pars Distalis, Hyperplasia           |                   1           2                                2         |             
      Pars Distalis, Pigmentation          |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      C-Cell, Hyperplasia                  | 1                       2                    2                           |             
      Follicular Cell, Cyst                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Spermatocele                         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +        M  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Inflammation, Chronic Active         |                                  2                          2            |             
      Necrosis                             |                                              2     2                     |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Abscess                              |                                                                          |             
      Epithelium, Hyperplasia              |    2                             3                 2                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Interstitial Cell, Hyperplasia       |    2  2              1  2           2        1  1  2        1        2   |             
      Seminiferous Tubule, Atrophy         |    2  2  2           2        2     2        2  2  2        2        3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 4| 7| 7| 6| 5| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 4| 4| 4| 3| 7| 5| 4| 4| 0| 7| 4| 4| 3| 7| 7| 4| 4| 3| 7| 7| 4| 4| 5| 3| 5|             
                                           | 4| 4| 4| 9| 6| 8| 5| 5| 5| 6| 6| 6| 8| 9| 6| 6| 6| 8| 6| 6| 5| 4| 8| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    79VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Mediastinal, Degeneration, Cystic    |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      | 1     1                                      2                           |             
      Mediastinal, Pigmentation            | 1     1                                      1                           |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     |    2                                                                     |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      | 2                                                           2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +        +  M  +     +  +  +  +     +  +  +        +  +     +   |             
      Degeneration, Cystic                 |                                  2                                   2   |             
      Degeneration                         |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +        +  +  M     +  +  +  +     +  +  +        +  +     +   |             
      Infiltration Cellular, Mast Cell     |                                                                          |             
      Infiltration Cellular, Histiocyte    | 2     2  2                    2     2  2           2        2  2         |             
      Pigmentation                         | 1     1                       2                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  M        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis                             |    3                                                                     |             
      Hematopoietic Cell Proliferation     |    2  2                 2     2  2  2  2     2     2           2         |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 2  2                    2                                                |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +        M  M  +     +  +  +  +     +  +  +        +  +     +   |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M        +  +  +     +  +  M  +     +  +  +        +  M     +   |             
      Galactocele                          |    X                                                                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Cyst Epithelial Inclusion            |    X                                                                     |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 4| 7| 7| 6| 5| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 4| 4| 4| 3| 7| 5| 4| 4| 0| 7| 4| 4| 3| 7| 7| 4| 4| 3| 7| 7| 4| 4| 5| 3| 5|             
                                           | 4| 4| 4| 9| 6| 8| 5| 5| 5| 6| 6| 6| 8| 9| 6| 6| 6| 8| 6| 6| 5| 4| 8| 9| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    79VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Congestion                           |    3                                         2                           |             
      Hemorrhage                           |                   1                 1                                    |             
      Infiltration Cellular, Histiocyte    |                                     1                       1            |             
      Inflammation, Acute                  |                         2                                                |             
      Alveolar Epithelium, Hyperplasia     | 1                                               1           2            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +        +  +  +     +  +  M  +     +  +  +        +  +     +   |             
      Fungus                               |                                                                          |             
      Inflammation, Acute                  |                                  3           2                       2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                +         |             
      Lens, Cataract                       |                                                                2         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                +         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
      Nephropathy                          | 2  2  2  2        2  2  2     1  3  2  2     3  2  3        2  2     2   |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
      Cortex, Mineralization               |                         2                                                |             
      Papilla, Mineralization              |                         2                                      2     1   |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Pigmentation           |    1  2  1              1     1     1           1  1           1     1   |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +        +  +  +     +  +  +  +     +  +  +        +  +     +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 5| 7| 7| 4| 6| 4| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 4| 3| 1| 5| 2| 4| 4| 5| 7| 7| 5| 3| 3| 7| 7| 4| 4| 9| 8| 4| 4| 4| 4| 2| 3|             
                                           | 4| 9| 6| 7| 0| 7| 4| 7| 0| 4| 0| 9| 8| 6| 6| 7| 7| 0| 1| 7| 7| 6| 4| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    79VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +     A  +  +  +  +        +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +     A  +  +  +  +        +  +  +  A  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +     A  +  +  +  +        +  +  +  +  A  +  +  +  +  A|             
      Parasite                             |                                                 2                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +     A  M  +  +  +        +  +  +  A  A  +  +  +  +  +|             
      Parasite                             |                                                                2         |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  +     A  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +  +     +  +  +  +  +        +  +  +  A  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A     +  +  +     A  +  +  +  +        +  +  +  A  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X           X  X     X     X  X  X        X  X  X     X  X  X  X  X  X|             
      Clear Cell Focus                     |    X                          X  X                          X     X      |             
      Cyst                                 |                                                 X                        |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                                              X                           |             
      Fatty Change, Diffuse                |             1                                            2               |             
      Fatty Change, Focal                  |                            2                                            1|             
      Fibrosis                             |                                  2                                       |             
      Hepatodiaphragmatic Nodule           |                X              X                                          |             
      Infarct                              |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                         3                                            2   |             
      Pigmentation                         |                                  2                                       |             
      Bile Duct, Hyperplasia               | 2           2                 2  3           2              2  2  2     2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +  +                       +|             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
      Fat, Mineralization                  |                                                 2                        |             
      Fat, Necrosis                        |                                                 3                       3|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                 3                        |             
      Acinus, Focal Cellular Change        |                                                                         1|             
      Acinus, Hyperplasia                  |                   3              2                                2      |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  A  +  +  M  +  +|             
      Acanthosis                           |       2           2        1                                         1   |             
      Hemorrhage                           |                            1                                             |             
      Hyperkeratosis                       |       2                                                                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 5| 7| 7| 4| 6| 4| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 4| 3| 1| 5| 2| 4| 4| 5| 7| 7| 5| 3| 3| 7| 7| 4| 4| 9| 8| 4| 4| 4| 4| 2| 3|             
                                           | 4| 9| 6| 7| 0| 7| 4| 7| 0| 4| 0| 9| 8| 6| 6| 7| 7| 0| 1| 7| 7| 6| 4| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    79VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  A  +  +  +  +  +|             
      Erosion                              |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2  2     2  2  2     3     2  2  2        2  2     2  2     2     2  2|             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               2                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  2              2                             1  1        2     2     2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +     +  +  M  +  +        +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +     +  M  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Angiectasis           |    2           2  2     3        3                       2              3|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           | 2  2              2           2     2                                1   |             
      Pars Distalis, Pigmentation          |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1                                                                     |             
      Follicular Cell, Cyst                |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Spermatocele                         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +     +  +  M     +  +  +  +  +        M  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |    2                                                              3      |             
                                            __________________________________________________________________________|             
   Prostate                                | M  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Epithelium, Hyperplasia              |    2           2                             2              2     2      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |             2                 1  1  1           1  1        2     2     2|             
      Seminiferous Tubule, Atrophy         | 2  2                          2  2  2                       2  2  2  2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 5| 7| 7| 4| 6| 4| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 4| 3| 1| 5| 2| 4| 4| 5| 7| 7| 5| 3| 3| 7| 7| 4| 4| 9| 8| 4| 4| 4| 4| 2| 3|             
                                           | 4| 9| 6| 7| 0| 7| 4| 7| 0| 4| 0| 9| 8| 6| 6| 7| 7| 0| 1| 7| 7| 6| 4| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    79VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +     +  +     +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Degeneration, Cystic    |                2                                                         |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                  2                                       |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                    2                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Degeneration                         |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mast Cell     |                2                                                         |             
      Infiltration Cellular, Histiocyte    | 2              2                 2           2              2        2   |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  A  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                 2                       2|             
      Fibrosis                             |    2                                                                     |             
      Hematopoietic Cell Proliferation     | 2                 2              2  2              2              2  3   |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                   2                             2  2                     |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  M  +  +  +|             
      Cyst                                 |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  M     +  +  M     +  M  +  +  +        M     +  +  M  M  M  +  M  M|             
      Galactocele                          |                                  X                                       |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +     +  M  +  +  +        M  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 5| 7| 7| 4| 6| 4| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 4| 3| 1| 5| 2| 4| 4| 5| 7| 7| 5| 3| 3| 7| 7| 4| 4| 9| 8| 4| 4| 4| 4| 2| 3|             
                                           | 4| 9| 6| 7| 0| 7| 4| 7| 0| 4| 0| 9| 8| 6| 6| 7| 7| 0| 1| 7| 7| 6| 4| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    79VM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 3                                                                        |             
      Hemorrhage                           |             3                                                           2|             
      Infiltration Cellular, Histiocyte    | 1  1                    3        1                                       |             
      Inflammation, Acute                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                      1   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                         2                                                |             
      Inflammation, Acute                  |                         2                                   2        3   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +     +                          +  +      |             
      Lens, Cataract                       |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +     +                          +  +      |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 3  2  2     2  2  3        1  2  2  1        2  3  2     1  2  2  2  3  2|             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
      Cortex, Mineralization               |                                                                          |             
      Papilla, Mineralization              |                                                                1         |             
      Renal Tubule, Hyperplasia            |                   1                                                      |             
      Renal Tubule, Pigmentation           |    2              2              2  1        1              1     1      |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +     +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4|                                                           |            |
                             DAY ON TEST   | 5| 5| 4| 4| 9|                                                           |            |
                                           | 0| 7| 7| 7| 9|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1|                                                           |      A     |
    VEHICLE                                | 6| 6| 6| 6| 6|                                                           |      L     |
    79VM                                   | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +  +  +                                                            |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +  +  +                                                            |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +  +  +                                                            |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +  +  +                                                            |  56        |
      Parasite                             |       X                                                                  |      4  1.3|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +  +  +                                                            |  54        |
      Parasite                             |                                                                          |      5  1.8|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +  +  +                                                            |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +  +  +                                                            |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +  +  +                                                            |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +  +  +                                                            |  53        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +  +  +                                                            |  60        |
      Basophilic Focus                     | X     X  X  X                                                            |     46     |
      Clear Cell Focus                     |                                                                          |     16     |
      Cyst                                 |                                                                          |      1     |
      Degeneration, Cystic                 |          1                                                               |      1  1.0|
      Eosinophilic Focus                   |                                                                          |      4     |
      Fatty Change, Diffuse                |                                                                          |      5  2.0|
      Fatty Change, Focal                  |             2                                                            |      9  1.4|
      Fibrosis                             |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      4     |
      Infarct                              |                                                                          |      1  4.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis                             |                                                                          |      2  2.5|
      Pigmentation                         |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               | 2                                                                        |     30  2.1|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   6        |
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  2.0|
      Fat, Inflammation, Chronic Active    |                                                                          |      1  1.0|
      Fat, Mineralization                  |                                                                          |      1  2.0|
      Fat, Necrosis                        |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +  +  +                                                            |  59        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Acinus, Focal Cellular Change        |                                                                          |      1  1.0|
      Acinus, Hyperplasia                  | 2                                                                        |     14  2.3|
      Artery, Inflammation, Chronic Active |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +  +  +                                                            |  60        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +     +  +  +                                                            |  59        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +  +  +                                                            |  57        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4|                                                           |            |
                             DAY ON TEST   | 5| 5| 4| 4| 9|                                                           |            |
                                           | 0| 7| 7| 7| 9|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1|                                                           |      A     |
    VEHICLE                                | 6| 6| 6| 6| 6|                                                           |      L     |
    79VM                                   | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Acanthosis                           |       2                                                                  |      8  1.9|
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperkeratosis                       |       2                                                                  |      5  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Necrosis                             |          2                                                               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +  +  +                                                            |  58        |
      Erosion                              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +  +  +                                                            |  60        |
      Cardiomyopathy                       | 2     2  2  2                                                            |     50  2.1|
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +  +  +                                                            |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +  +  +                                                            |  60        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +     +  +  +                                                            |  60        |
      Hyperplasia                          | 2     2  1                                                               |     25  1.6|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +  +  +                                                            |  58        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     +  +  +                                                            |  56        |
      Hyperplasia                          | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +  +                                                            |  56        |
      Cyst                                 |                                                                          |      1     |
      Pars Distalis, Angiectasis           |       3  2                                                               |     18  2.4|
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |                                                                          |     14  1.8|
      Pars Distalis, Pigmentation          | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +  +  +                                                            |  60        |
      C-Cell, Hyperplasia                  |                                                                          |      6  1.3|
      Follicular Cell, Cyst                |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +     +  +  +                                                            |  60        |
      Spermatocele                         |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4|                                                           |            |
                             DAY ON TEST   | 5| 5| 4| 4| 9|                                                           |            |
                                           | 0| 7| 7| 7| 9|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1|                                                           |      A     |
    VEHICLE                                | 6| 6| 6| 6| 6|                                                           |      L     |
    79VM                                   | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +     +  M  +                                                            |  56        |
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
      Necrosis                             |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +     +  +  +                                                            |  59        |
      Abscess                              |          4                                                               |      1  4.0|
      Epithelium, Hyperplasia              | 1                                                                        |     12  1.9|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +     +  +  +                                                            |  60        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +     +  +  +                                                            |  60        |
      Interstitial Cell, Hyperplasia       |             2                                                            |     26  1.6|
      Seminiferous Tubule, Atrophy         |                                                                          |     29  2.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +  +  +                                                            |  59        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +  +  +                                                            |  60        |
      Mediastinal, Degeneration, Cystic    |                                                                          |      1  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |             2                                                            |      8  1.4|
      Mediastinal, Pigmentation            |                                                                          |      6  1.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  2.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +  +  +                                                            |  58        |
      Degeneration, Cystic                 |       2                                                                  |      5  2.0|
      Degeneration                         | 2                                                                        |      1  2.0|
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      2  1.5|
      Pigmentation                         |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +  +  +                                                            |  59        |
      Infiltration Cellular, Mast Cell     |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |          2  2                                                            |     26  1.8|
      Pigmentation                         |                                                                          |      9  1.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +  +                                                            |  58        |
      Depletion Lymphoid                   |                                                                          |      2  2.0|
      Fibrosis                             |                                                                          |      3  2.3|
      Hematopoietic Cell Proliferation     |       2                                                                  |     24  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |       2                                                                  |     15  1.7|
      Pigmentation, Hemosiderin            |                                                                          |      9  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4|                                                           |            |
                             DAY ON TEST   | 5| 5| 4| 4| 9|                                                           |            |
                                           | 0| 7| 7| 7| 9|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1|                                                           |      A     |
    VEHICLE                                | 6| 6| 6| 6| 6|                                                           |      L     |
    79VM                                   | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +  +  +                                                            |  55        |
      Cyst                                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     M  M  +                                                            |  42        |
      Galactocele                          | X                                                                        |      4     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +  +                                                            |  58        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +  +  +                                                            |  60        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +  +  +                                                            |  60        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +  +  +                                                            |  60        |
      Congestion                           | 2                                                                        |      6  2.8|
      Hemorrhage                           |                                                                          |      4  1.8|
      Infiltration Cellular, Histiocyte    |                                                                          |      9  1.3|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      4  1.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +  +  +                                                            |  59        |
      Fungus                               |                                                                          |      1  2.0|
      Inflammation, Acute                  | 2                                                                        |      8  2.1|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +  +  +                                                            |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   6        |
      Lens, Cataract                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   6        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4|                                                           |            |
                             DAY ON TEST   | 5| 5| 4| 4| 9|                                                           |            |
                                           | 0| 7| 7| 7| 9|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1|                                                           |      A     |
    VEHICLE                                | 6| 6| 6| 6| 6|                                                           |      L     |
    79VM                                   | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +  +  +                                                            |  60        |
      Nephropathy                          | 4     3  3  1                                                            |     56  2.1|
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  2.0|
      Cortex, Mineralization               |                                                                          |      1  2.0|
      Papilla, Mineralization              | 1                                                                        |      6  1.3|
      Renal Tubule, Hyperplasia            |                                                                          |      1  1.0|
      Renal Tubule, Pigmentation           |             1                                                            |     24  1.2|
      Transitional Epithelium, Hyperplasia |       1                                                                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +  +  +                                                            |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 4| 7| 5| 4| 4| 7| 7| 5| 2| 6| 5| 7| 3| 5| 4| 7| 6| 5| 5|             
                             DAY ON TEST   | 3| 3| 5| 7| 5| 4| 5| 3| 7| 5| 5| 4| 4| 7| 5| 6| 7| 4| 7| 3| 5| 4| 5| 7| 7|             
                                           | 9| 9| 3| 6| 7| 3| 8| 9| 6| 8| 8| 3| 3| 6| 3| 7| 6| 3| 0| 6| 8| 3| 9| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.025 G/                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    KG 79 LM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +        +     +           +  +     +  +     +  A  +     +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +        +     +           +  +     +  +     +  A  +     +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +        +     +           +  +     +  +     +  A  +     +  +      |             
      Parasite                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +        +     +           +  +     +  A     +  A  +     +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +        +     +           +  +     +  +     +  A  +     +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +        +     +           +  +     +  +     +  A  +     +  +      |             
      Pigmentation                         |    1  1                             1                             1      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +        +     +           +  +     +  A     +  A  +     +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +        +     +           +  +     +  A     +  A  +     +  +      |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +        +     +           +  +     +  +     +  A  +     +  +      |             
      Basophilic Focus                     | X     X                          X  X        X     X     X        X      |             
      Clear Cell Focus                     | X                                   X              X           X         |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |    X                                                                     |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Focal                  |       2                          2  1     2              2     1         |             
      Hepatodiaphragmatic Nodule           |                                     X     X                              |             
      Infarct                              |                                                                          |             
      Inflammation, Granulomatous          | 1  2  1                          1                             1         |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation                         | 1  1  2        1     1           1  1        1                 1  2      |             
      Bile Duct, Hyperplasia               |                      2                       2     2                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
      Fibrosis                             |                                                                          |             
      Fat, Inflammation, Chronic Active    |                                  2                                       |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +        +     +           +  +     +  +     +  A  +     +  +      |             
      Acinus, Hyperplasia                  | 2  3           2     1                                                   |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +        +     +           +  +     +  +     +  A  +     +  +      |             
      Fat, Proliferation                   |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +        +     +           +  +     +  +     +  A  +     +  +      |             
      Acanthosis                           | 2                                                  3     1     2         |             
      Fibrosis                             |                                                                          |             
      Hyperkeratosis                       |                                           2        2                     |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                    2              2      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +        +     +           +  +     +  +     +  A  +     +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 4| 7| 5| 4| 4| 7| 7| 5| 2| 6| 5| 7| 3| 5| 4| 7| 6| 5| 5|             
                             DAY ON TEST   | 3| 3| 5| 7| 5| 4| 5| 3| 7| 5| 5| 4| 4| 7| 5| 6| 7| 4| 7| 3| 5| 4| 5| 7| 7|             
                                           | 9| 9| 3| 6| 7| 3| 8| 9| 6| 8| 8| 3| 3| 6| 3| 7| 6| 3| 0| 6| 8| 3| 9| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.025 G/                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    KG 79 LM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion                              |       2                                                  1               |             
      Fibrosis                             |                1                 2           2     2           3         |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                                                1         |             
      Hyperplasia, Adenomatous             |                                                                          |             
      Inflammation, Acute                  |       2                                                                  |             
      Metaplasia                           |                                  2           1                 2         |             
      Mineralization                       |                                                                   2      |             
      Pigmentation                         |       1                                      1                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
      Cardiomyopathy                       | 2  2  2        2     2           2  3        2     2  2  2     2  2      |             
      Mineralization                       |                                                                   3      |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
      Hyperplasia                          |                                  1  1                          2         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +        +     +           +  +     +  +     +  A  +     +  +      |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +        +     +           +  +     +  M     +  M  +     +  +      |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
      Pars Distalis, Angiectasis           |                2     3                                            3      |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |       2                             2                                    |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
      Rathke's Cleft, Cyst                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +        +     +           +  +     +  +     +  A  +     +  +      |             
      C-Cell, Hyperplasia                  |                      1                                                   |             
      Follicular Cell, Cyst                |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +        +     +           +  +        +     +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +        +     +           +  M        +     +  +  +     +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 4| 7| 5| 4| 4| 7| 7| 5| 2| 6| 5| 7| 3| 5| 4| 7| 6| 5| 5|             
                             DAY ON TEST   | 3| 3| 5| 7| 5| 4| 5| 3| 7| 5| 5| 4| 4| 7| 5| 6| 7| 4| 7| 3| 5| 4| 5| 7| 7|             
                                           | 9| 9| 3| 6| 7| 3| 8| 9| 6| 8| 8| 3| 3| 6| 3| 7| 6| 3| 0| 6| 8| 3| 9| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.025 G/                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    KG 79 LM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Epithelium, Hyperplasia              | 2                    2                                                   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +        +     +           +  +        +     +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
      Atrophy                              |                                                                          |             
      Interstitial Cell, Hyperplasia       |    2           2                    1                    2               |             
      Seminiferous Tubule, Atrophy         | 2  2  2        2                    2     2                    3         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
      Pigmentation                         |                1     1           1           1                 1         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                                          |             
      Mediastinal, Pigmentation            | 2  2                             2           2     2                     |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |    2                                                                     |             
      Pancreatic, Pigmentation             |    2                                         1                           |             
      Renal, Angiectasis                   |                                                                          |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                                                          |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M        +     +           +  +     +  +     +  +  +     +  +      |             
      Degeneration, Cystic                 |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Pigmentation                         | 1                                            1     1  1        1  1      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +        +     +           +  +     +  M     +  +  +     +  +      |             
      Infiltration Cellular, Mast Cell     |                                                                          |             
      Infiltration Cellular, Histiocyte    | 2  2  2              2           2                 2     1     2         |             
      Pigmentation                         | 2  2  2              2           3                 2  1        2  2      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +        +     +           +  +     +  M     +  A  +     +  +      |             
      Angiectasis                          |                                                                          |             
      Depletion Lymphoid                   |                                                                   2      |             
      Fibrosis                             |                                     2                                    |             
      Hematopoietic Cell Proliferation     |    2  2              3           2                 2           2  2      |             
      Infiltration Cellular, Histiocyte    |       1                          1                                2      |             
      Pigmentation, Hemosiderin            | 2  2  1                          2  2     2                    2  3      |             
      Pigmentation                         | 2     1        2                 2  1                          2  1      |             
      Capsule, Cyst                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +        M     M           +  +     +  M     +  +  +     +  +      |             
      Depletion Lymphoid                   |                                                                   2      |             
      Hemorrhage                           |                                           2                              |             
      Pigmentation                         | 1     1                          1  1              1           1  2      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 4| 7| 5| 4| 4| 7| 7| 5| 2| 6| 5| 7| 3| 5| 4| 7| 6| 5| 5|             
                             DAY ON TEST   | 3| 3| 5| 7| 5| 4| 5| 3| 7| 5| 5| 4| 4| 7| 5| 6| 7| 4| 7| 3| 5| 4| 5| 7| 7|             
                                           | 9| 9| 3| 6| 7| 3| 8| 9| 6| 8| 8| 3| 3| 6| 3| 7| 6| 3| 0| 6| 8| 3| 9| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.025 G/                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    KG 79 LM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M        +     +           +  M     +  M     M  M  +     M  +      |             
      Galactocele                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
      Hyperkeratosis                       |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
      Costochondral Junction, Fibrosis     |                                                                          |             
      Costochondral Junction, Inflammation,|                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
      Atelectasis                          |                                     2                          1         |             
      Congestion                           |                                                       2                  |             
      Edema                                |                                           2              1        1      |             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |       1                                   2                              |             
      Infiltration Cellular, Histiocyte    | 1  1  1        2     2           2  2     2  2     1           2  2      |             
      Inflammation, Acute                  |                                              3                    1      |             
      Inflammation, Granulomatous          |                                     1     2           1        1         |             
      Mineralization                       |                                     2                                    |             
      Pigmentation                         |    1  1                             2     2  1        1  1     2  2      |             
      Pigmentation, Cholesterol            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Bronchiole, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
      Fungus                               | 2                                                              2         |             
      Inflammation, Acute                  | 3                                                  1           2  2      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
      Erosion                              |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Canal, Inflammation, Acute           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                    +           +                 +                     |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 4| 7| 5| 4| 4| 7| 7| 5| 2| 6| 5| 7| 3| 5| 4| 7| 6| 5| 5|             
                             DAY ON TEST   | 3| 3| 5| 7| 5| 4| 5| 3| 7| 5| 5| 4| 4| 7| 5| 6| 7| 4| 7| 3| 5| 4| 5| 7| 7|             
                                           | 9| 9| 3| 6| 7| 3| 8| 9| 6| 8| 8| 3| 3| 6| 3| 7| 6| 3| 0| 6| 8| 3| 9| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.025 G/                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    KG 79 LM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  | 2                                                                        |             
      Lens, Cataract                       |                                  2                 2                     |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                    +           +                 +              +      |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +        +     +           +  +     +  +     +  +  +     +  +      |             
      Nephropathy                          | 2  2  1        2     2              2              2     1     2  2      |             
      Pigmentation                         |                                     1                                    |             
      Cortex, Mineralization               |                                                                   3      |             
      Papilla, Mineralization              |    1  1        1                                   1                     |             
      Renal Tubule, Hyperplasia            |                                     1                                    |             
      Renal Tubule, Pigmentation           | 1  1  1                          1                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +        +     +           +  +     +  +     +  A  +     +  +      |             
      Calculus Gross Observation           |                                                    X                     |             
      Calculus Micro Observation Only      |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 0| 7| 7| 7| 6| 5| 7| 4| 7| 7| 6| 4| 7| 7| 6| 5| 7| 5| 5| 4| 4|             
                             DAY ON TEST   | 4| 4| 5| 3| 5| 4| 4| 1| 2| 7| 4| 5| 4| 0| 0| 5| 4| 3| 9| 7| 4| 8| 7| 5| 0|             
                                           | 3| 0| 7| 8| 4| 0| 4| 7| 8| 6| 0| 7| 0| 1| 3| 8| 3| 9| 7| 6| 4| 3| 6| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.025 G/                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    KG 79 LM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +  +  +  +  +  +     +     +  A  +     +  +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  M  +  +  +  +     +     +  A  A     +  +  +     +  +        A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | M  +     +  +  +  +  +  +     +     +  A  +     +  +  +     +  +        A|             
      Parasite                             |                         2                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +  +  +  +  +     +     +  A  +     +  +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +  A  +  +  +  +     +     +  A  +     +  +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  A  +  +  +  +     +     +  A  +     +  +  +     +  +        A|             
      Pigmentation                         | 1  1     1           1        1     1     1     1  1        1            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     M  A  +  +  +  +     +     +  A  +     +  +  +     +  +        A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  A  +  +  +  +     +     +  A  +     +  +  +     +  +        A|             
      Pigmentation                         |          1                                                               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Basophilic Focus                     | X  X     X     X  X  X  X           X     X     X  X  X     X  X         |             
      Clear Cell Focus                     |          X     X  X                 X     X                 X            |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                      X  X     X                 X                        |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Focal                  | 1                    2  1                 1                             2|             
      Hepatodiaphragmatic Nodule           |                   X                                                      |             
      Infarct                              |                                                                          |             
      Inflammation, Granulomatous          |          1        1                 1           2                        |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation                         | 1  1     2     1  1  1        2     2     1     2  1  1     1            |             
      Bile Duct, Hyperplasia               |          2     2              2           2                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                +         |             
      Fibrosis                             |                                                                          |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  A  +  +  +  +     +     +  A  +     +  +  +     +  +        +|             
      Acinus, Hyperplasia                  | 2                       2     2           2     2  2  2     2            |             
      Artery, Inflammation, Chronic Active |                                                             2            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Fat, Proliferation                   |                                     1           1                        |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Acanthosis                           | 1        3     2     2  1                             1     2           1|             
      Fibrosis                             |                                                                          |             
      Hyperkeratosis                       | 2        2  3                          2                    2            |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 0| 7| 7| 7| 6| 5| 7| 4| 7| 7| 6| 4| 7| 7| 6| 5| 7| 5| 5| 4| 4|             
                             DAY ON TEST   | 4| 4| 5| 3| 5| 4| 4| 1| 2| 7| 4| 5| 4| 0| 0| 5| 4| 3| 9| 7| 4| 8| 7| 5| 0|             
                                           | 3| 0| 7| 8| 4| 0| 4| 7| 8| 6| 0| 7| 0| 1| 3| 8| 3| 9| 7| 6| 4| 3| 6| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.025 G/                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    KG 79 LM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion                              |                      1                                                   |             
      Fibrosis                             |    2                 1  1           2     1     2     2     2           2|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                                       1        2         |             
      Hyperplasia, Adenomatous             |    2                                                                     |             
      Inflammation, Acute                  |    2                                                                     |             
      Metaplasia                           |    2                                2     1     1     1     1  1         |             
      Mineralization                       |                                                                          |             
      Pigmentation                         |                         1     1                 2                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Cardiomyopathy                       | 2  2     2  1  2  2  2  2     2     3  2  2     2  3  2     3  2        3|             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Hyperplasia                          |                      2        2                             2            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Hyperplasia                          |                   2  2        2                       2        1         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  A  +  +  +  +     +     +  A  +     +  +  +     +  +        +|             
      Hyperplasia                          |    2                                               2                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  M  +  +  +  M     +     +  +  +     +  +  +     +  +        M|             
      Hyperplasia                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Pars Distalis, Angiectasis           |                   2  2        3     3           2     2                  |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |    3                    2                                      2         |             
      Pars Intermedia, Hyperplasia         |                                                                2         |             
      Rathke's Cleft, Cyst                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  A  +  +  +  +     +     +  A  +     +  +  +     +  +        A|             
      C-Cell, Hyperplasia                  |                               2                                          |             
      Follicular Cell, Cyst                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +  +  +  +  +  +     +     +  A  +     +  +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Inflammation, Chronic Active         |                      3                                                   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +     M  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 0| 7| 7| 7| 6| 5| 7| 4| 7| 7| 6| 4| 7| 7| 6| 5| 7| 5| 5| 4| 4|             
                             DAY ON TEST   | 4| 4| 5| 3| 5| 4| 4| 1| 2| 7| 4| 5| 4| 0| 0| 5| 4| 3| 9| 7| 4| 8| 7| 5| 0|             
                                           | 3| 0| 7| 8| 4| 0| 4| 7| 8| 6| 0| 7| 0| 1| 3| 8| 3| 9| 7| 6| 4| 3| 6| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.025 G/                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    KG 79 LM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Atrophy                              |                                                                          |             
      Interstitial Cell, Hyperplasia       | 2                 1     1     2     2     2           1                  |             
      Seminiferous Tubule, Atrophy         | 2  2           2  2  4  2           2     2     2  2        2  2         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +  +  +  +     +     +  A  +     +  +  +     +  +        +|             
      Pigmentation                         | 1  1           2  1                       1     1  2  1     1            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                         1                                      2         |             
      Mediastinal, Pigmentation            | 2  2     2     2     2        2                 2     2     2            |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |    2                                            2                        |             
      Pancreatic, Pigmentation             |    2                                            2                        |             
      Renal, Angiectasis                   |                                                                          |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                                                          |             
      Renal, Pigmentation                  |                2                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     M  +        +|             
      Degeneration, Cystic                 |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Pigmentation                         | 2  1     1           1  1     1                 1  1  1                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  +  +  +  +     +     +  A  +     +  +  +     +  M        M|             
      Infiltration Cellular, Mast Cell     |                                                                          |             
      Infiltration Cellular, Histiocyte    | 2  2     2     2  2  2  1     2           2     2  2  2     2            |             
      Pigmentation                         | 2  2     2     2  2  2        2     2     1     2  2  2     2            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +  +  +  +     +     +  A  +     +  +  +     +  +        +|             
      Angiectasis                          |                               2                                          |             
      Depletion Lymphoid                   |          1                          2                                    |             
      Fibrosis                             |                2              3                                          |             
      Hematopoietic Cell Proliferation     | 2  2     2     2  2  3              2           2  2  2     2            |             
      Infiltration Cellular, Histiocyte    | 2        1        1  2              1           2  1                     |             
      Pigmentation, Hemosiderin            | 2  1     1     2  2  2        2     2           2  2  2     2            |             
      Pigmentation                         | 2  2           2  1  2        2     2           2  2  2     2            |             
      Capsule, Cyst                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +     +  +  +  M  +  +     M     +  +  +     +  +  +     +  +        +|             
      Depletion Lymphoid                   |                                     2                       2            |             
      Hemorrhage                           |                                                                          |             
      Pigmentation                         |          1     1     1              1  1           1  1     1            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 0| 7| 7| 7| 6| 5| 7| 4| 7| 7| 6| 4| 7| 7| 6| 5| 7| 5| 5| 4| 4|             
                             DAY ON TEST   | 4| 4| 5| 3| 5| 4| 4| 1| 2| 7| 4| 5| 4| 0| 0| 5| 4| 3| 9| 7| 4| 8| 7| 5| 0|             
                                           | 3| 0| 7| 8| 4| 0| 4| 7| 8| 6| 0| 7| 0| 1| 3| 8| 3| 9| 7| 6| 4| 3| 6| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.025 G/                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    KG 79 LM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M     +  M  M  +  +  +     M     +  +  +     +  +  +     +  M        +|             
      Galactocele                          |                                                       X                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Hyperkeratosis                       |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Costochondral Junction, Fibrosis     |                                                                          |             
      Costochondral Junction, Inflammation,|                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Atelectasis                          |          1        1                    1                    2            |             
      Congestion                           | 2           3                             3                              |             
      Edema                                |                         2              2                                 |             
      Fibrosis                             |                                        1                                 |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 3  2     2     2  2  1        2     2  2  1     2  2  2     2  2         |             
      Inflammation, Acute                  |                                           2                              |             
      Inflammation, Granulomatous          |                   1     1           1                                    |             
      Mineralization                       |                                                                          |             
      Pigmentation                         |    1     1     1  1     2     1     1  1        2     1     2            |             
      Pigmentation, Cholesterol            |                   2                 2                                    |             
      Alveolar Epithelium, Hyperplasia     | 2  2                 1                                                   |             
      Bronchiole, Hyperplasia              |                                                                1         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Fungus                               |                               2     2           3           3            |             
      Inflammation, Acute                  |                               2     2           2  2        3  3         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        A|             
      Erosion                              |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Canal, Inflammation, Acute           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +           +  +           +                                          |             
      Hemorrhage                           |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 0| 7| 7| 7| 6| 5| 7| 4| 7| 7| 6| 4| 7| 7| 6| 5| 7| 5| 5| 4| 4|             
                             DAY ON TEST   | 4| 4| 5| 3| 5| 4| 4| 1| 2| 7| 4| 5| 4| 0| 0| 5| 4| 3| 9| 7| 4| 8| 7| 5| 0|             
                                           | 3| 0| 7| 8| 4| 0| 4| 7| 8| 6| 0| 7| 0| 1| 3| 8| 3| 9| 7| 6| 4| 3| 6| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.025 G/                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    KG 79 LM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Lens, Cataract                       |                3              2                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +           +  +                                                      |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +  +  +     +     +  +  +     +  +  +     +  +        +|             
      Nephropathy                          | 2  1     2     1  2     1     2     3           2     2     2            |             
      Pigmentation                         |                                                                          |             
      Cortex, Mineralization               |                                                                          |             
      Papilla, Mineralization              |          1     2              1     1  1           1                     |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Pigmentation           |    1     2              1     1           1                    3         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +  +  +  +     +     +  A  +     +  +  +     +  +        A|             
      Calculus Gross Observation           |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 7| 5| 4| 3| 7| 7| 7| 7| 5| 7| 4| 7| 5| 5| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 1| 3| 7| 0| 4| 3| 5| 8| 0| 4| 3| 3| 3| 8| 4| 5| 4| 6| 2| 4| 4| 3| 3| 3|             
                                           | 8| 8| 4| 6| 0| 3| 8| 3| 4| 6| 3| 9| 8| 8| 2| 3| 7| 3| 7| 6| 3| 3| 2| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.025 G/                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    KG 79 LM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  M  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +  +  +  +|             
      Parasite                             |                   2                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +  +  +  +|             
      Pigmentation                         |    1              1  1              1  1     1              1     1  1   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +  +  +  +|             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X              X  X  X           X  X  X     X     X        X  X  X  X   |             
      Clear Cell Focus                     | X                                X     X           X                     |             
      Degeneration, Cystic                 |       1        2                       1                                 |             
      Eosinophilic Focus                   |                   X                                         X            |             
      Fatty Change, Diffuse                |                2           2              4           2              1   |             
      Fatty Change, Focal                  |       1           1  1                                   1        1     1|             
      Hepatodiaphragmatic Nodule           |                X                                            X            |             
      Infarct                              |                                                                      3   |             
      Inflammation, Granulomatous          |                   1              2  1        2     2        2     2      |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |    2                                                                     |             
      Pigmentation                         | 1              2  1  1        1  2  2  2     2     1        2  1  2  1   |             
      Bile Duct, Hyperplasia               |             1  2  2              2  2        2     2           1         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +                       +         |             
      Fibrosis                             |                                                                3         |             
      Fat, Inflammation, Chronic Active    |                                                                3         |             
      Fat, Necrosis                        |                                        3                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  M  +  +  +  +  +  +|             
      Acinus, Hyperplasia                  | 2                    2        2              2                 2  2     2|             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                       3                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Fat, Proliferation                   |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Acanthosis                           |       2        2  2                          2     1        2  2  2  1   |             
      Fibrosis                             |                                                                4         |             
      Hyperkeratosis                       |       2                 2                    2                           |             
      Inflammation, Chronic                |                                                                4         |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 7| 5| 4| 3| 7| 7| 7| 7| 5| 7| 4| 7| 5| 5| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 1| 3| 7| 0| 4| 3| 5| 8| 0| 4| 3| 3| 3| 8| 4| 5| 4| 6| 2| 4| 4| 3| 3| 3|             
                                           | 8| 8| 4| 6| 0| 3| 8| 3| 4| 6| 3| 9| 8| 8| 2| 3| 7| 3| 7| 6| 3| 3| 2| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.025 G/                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    KG 79 LM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion                              |       1              1  2                 1                              |             
      Fibrosis                             | 1     2              2  2  2  1     1        2     2     2     2  2  2  2|             
      Hemorrhage                           |       1                                                                  |             
      Hyperplasia                          |                      2  1  2              2                       2     2|             
      Hyperplasia, Adenomatous             |                               2                                          |             
      Inflammation, Acute                  |                               1           1                       2     1|             
      Metaplasia                           | 1     1        1     1  2  2        2     1  2     1     2     1  2  1  1|             
      Mineralization                       |                                        2                                 |             
      Pigmentation                         |             1                                               1            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  2     2  2  3  2     1  2  2  2     2  2     2  2     2     2  2   |             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2              2  1  2           3           2     2        2            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 3                 1  2              2                    3               |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                         2     2              2                          2|             
      Pars Intermedia, Hyperplasia         |                                                                          |             
      Rathke's Cleft, Cyst                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                           1                       1      |             
      Follicular Cell, Cyst                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +     +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 7| 5| 4| 3| 7| 7| 7| 7| 5| 7| 4| 7| 5| 5| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 1| 3| 7| 0| 4| 3| 5| 8| 0| 4| 3| 3| 3| 8| 4| 5| 4| 6| 2| 4| 4| 3| 3| 3|             
                                           | 8| 8| 4| 6| 0| 3| 8| 3| 4| 6| 3| 9| 8| 8| 2| 3| 7| 3| 7| 6| 3| 3| 2| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.025 G/                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    KG 79 LM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Epithelium, Hyperplasia              |                               2                    2                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Atrophy                              |                            3                                             |             
      Interstitial Cell, Hyperplasia       |             2     1  2  2  1  2  2                    2  2     2        2|             
      Seminiferous Tubule, Atrophy         | 2     2        2  2  2        2  2        3        2        2  3  2      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +  +  +  +|             
      Pigmentation                         |                               1     2  1     1              1  1         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |       2                                                                  |             
      Mediastinal, Pigmentation            | 1              2                             2     2                     |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                         3              2                       2         |             
      Pancreatic, Pigmentation             |                2                       2                       2         |             
      Renal, Angiectasis                   |                         2                                                |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                         2                                                |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +  +  +  +  +  M  +  +  M  +  +  +     +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                   2      |             
      Infiltration Cellular, Plasma Cell   |                                              3                           |             
      Infiltration Cellular, Histiocyte    |                      1                    2                             1|             
      Pigmentation                         | 1  1        2  1  1           2  2     1           1        1     1  1   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +  M  +  +  +  +  +  +     +  A  +  +  +  +  +  +|             
      Infiltration Cellular, Mast Cell     |                                                                         2|             
      Infiltration Cellular, Histiocyte    | 2  1  2           2  2  2     3     2  2  2  2     2     2     2        2|             
      Pigmentation                         | 2  2        2  2  2  2        3  2  2  2     3     3        2  2  1  2  2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Depletion Lymphoid                   |                   2                                                      |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     | 2  3           3     3     2  2  2     2  2  2     2     2  2  2     3   |             
      Infiltration Cellular, Histiocyte    | 1                 1  2     2  2  1  1  1                       1  2  2  1|             
      Pigmentation, Hemosiderin            | 2           2  1  2           2  1  2  1     2     2        2  2  2  2   |             
      Pigmentation                         | 2              2  1           2  2  2  2     2     2        2  2  2  2   |             
      Capsule, Cyst                        |                   X                                                      |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +     +  +  +  +  +  +  +  +  M  +  +  +     +     +  +  +  +  +  +|             
      Depletion Lymphoid                   |                               2                                          |             
      Hemorrhage                           |                                                                          |             
      Pigmentation                         |                1     1                 1     1              1  1  2  1  1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 7| 5| 4| 3| 7| 7| 7| 7| 5| 7| 4| 7| 5| 5| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 1| 3| 7| 0| 4| 3| 5| 8| 0| 4| 3| 3| 3| 8| 4| 5| 4| 6| 2| 4| 4| 3| 3| 3|             
                                           | 8| 8| 4| 6| 0| 3| 8| 3| 4| 6| 3| 9| 8| 8| 2| 3| 7| 3| 7| 6| 3| 3| 2| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.025 G/                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    KG 79 LM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +     M  +  M  M  M  +  +  +  M  +  +  M     +     +  M  +  +  M  +|             
      Galactocele                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                      2   |             
      Metaplasia, Osseous                  |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Costochondral Junction, Fibrosis     |                                                                          |             
      Costochondral Junction, Inflammation,|                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Atelectasis                          |                   1           1        2                          2      |             
      Congestion                           |             3                                                            |             
      Edema                                |       3                                               3  1               |             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |                                           2                              |             
      Infiltration Cellular, Histiocyte    | 1  2           2  2  1  1  1  2  2  3  2     1     1     1  2  2  2     1|             
      Inflammation, Acute                  |    2  3        1     1                                3              2  1|             
      Inflammation, Granulomatous          |                   2           1        1                                 |             
      Mineralization                       |       1           1                                                      |             
      Pigmentation                         |    2  2        1  2  1        2     1                    1     1  1     2|             
      Pigmentation, Cholesterol            |                                        1                                 |             
      Alveolar Epithelium, Hyperplasia     |                                                    2        2            |             
      Bronchiole, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Fungus                               |                                                                          |             
      Inflammation, Acute                  |       2              3        2  2                    3              2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +  +  +  +|             
      Erosion                              |                                                                      2   |             
      Inflammation, Acute                  |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                     +     +  +                           |             
      Canal, Inflammation, Acute           |                                     2        4                           |             
                                            __________________________________________________________________________|             
   Eye                                     |                +  +     +                                +               |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 4| 7| 7| 5| 4| 3| 7| 7| 7| 7| 5| 7| 4| 7| 5| 5| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 1| 3| 7| 0| 4| 3| 5| 8| 0| 4| 3| 3| 3| 8| 4| 5| 4| 6| 2| 4| 4| 3| 3| 3|             
                                           | 8| 8| 4| 6| 0| 3| 8| 3| 4| 6| 3| 9| 8| 8| 2| 3| 7| 3| 7| 6| 3| 3| 2| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.025 G/                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    KG 79 LM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Lens, Cataract                       |                                                          2               |             
      Retina, Atrophy                      |                2                                                         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +                                                      |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                         +                    +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Nephropathy                          | 3  2  2     1  2  2           1  1  2  2     2     2        1  2  1  1   |             
      Pigmentation                         |                                  1                                       |             
      Cortex, Mineralization               |                                     1              1                     |             
      Papilla, Mineralization              |    1                 1                                1           1      |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Pigmentation           |                1     1                 1  1  1              1        1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  A  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                                          |             
      Calculus Micro Observation Only      |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 4|                                                           |            |
                             DAY ON TEST   | 4| 5| 1| 0| 7|                                                           |            |
                                           | 3| 0| 1| 9| 4|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3|                                                           |      A     |
    0.025 G/                               | 2| 2| 2| 2| 2|                                                           |      L     |
    KG 79 LM                               | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  A  +  +  +                                                            |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +                                                            |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  A  +  +  +                                                            |  54        |
      Parasite                             |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +  +                                                            |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  A  +  +  +                                                            |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  +                                                            |  54        |
      Pigmentation                         |                                                                          |     23  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +                                                            |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +                                                            |  53        |
      Pigmentation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |  59        |
      Basophilic Focus                     | X                                                                        |     36     |
      Clear Cell Focus                     |                                                                          |     14     |
      Degeneration, Cystic                 |                                                                          |      3  1.3|
      Eosinophilic Focus                   |                                                                          |      7     |
      Fatty Change, Diffuse                |       2                                                                  |      6  2.2|
      Fatty Change, Focal                  |          2  1                                                            |     19  1.4|
      Hepatodiaphragmatic Nodule           |                                                                          |      5     |
      Infarct                              |                                                                          |      1  3.0|
      Inflammation, Granulomatous          |                                                                          |     16  1.4|
      Mixed Cell Focus                     | X                                                                        |      1     |
      Necrosis                             |                                                                          |      1  2.0|
      Pigmentation                         | 1  1                                                                     |     39  1.3|
      Bile Duct, Hyperplasia               |                                                                          |     15  1.9|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Fibrosis                             |                                                                          |      1  3.0|
      Fat, Inflammation, Chronic Active    |                                                                          |      2  2.5|
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |  56        |
      Acinus, Hyperplasia                  | 1                                                                        |     20  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |  59        |
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +                                                            |  59        |
      Fat, Proliferation                   |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |  59        |
      Acanthosis                           |    1  1  1  2                                                            |     25  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  90                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 4|                                                           |            |
                             DAY ON TEST   | 4| 5| 1| 0| 7|                                                           |            |
                                           | 3| 0| 1| 9| 4|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3|                                                           |      A     |
    0.025 G/                               | 2| 2| 2| 2| 2|                                                           |      L     |
    KG 79 LM                               | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis                             |                                                                          |      1  4.0|
      Hyperkeratosis                       |    2     2  2                                                            |     13  2.1|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |  59        |
      Erosion                              |          1  3                                                            |      9  1.4|
      Fibrosis                             |    1        1                                                            |     30  1.7|
      Hemorrhage                           |          1                                                               |      2  1.0|
      Hyperplasia                          |          2                                                               |     10  1.7|
      Hyperplasia, Adenomatous             |                                                                          |      2  2.0|
      Inflammation, Acute                  |       2  2  3                                                            |      9  1.8|
      Metaplasia                           |          1                                                               |     26  1.4|
      Mineralization                       |                                                                          |      2  2.0|
      Pigmentation                         |          1                                                               |      8  1.1|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |  60        |
      Cardiomyopathy                       | 2  2  2                                                                  |     52  2.1|
      Mineralization                       |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +                                                            |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +                                                            |  60        |
      Hyperplasia                          |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +                                                            |  60        |
      Hyperplasia                          |    2  3                                                                  |     18  1.9|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |  56        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +                                                            |  54        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |  59        |
      Pars Distalis, Angiectasis           |       3                                                                  |     15  2.4|
      Pars Distalis, Cyst                  |             X                                                            |      1     |
      Pars Distalis, Hyperplasia           | 2        2                                                               |     11  2.1|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  2.0|
      Rathke's Cleft, Cyst                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |  55        |
      C-Cell, Hyperplasia                  |       2                                                                  |      5  1.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  91                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 4|                                                           |            |
                             DAY ON TEST   | 4| 5| 1| 0| 7|                                                           |            |
                                           | 3| 0| 1| 9| 4|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3|                                                           |      A     |
    0.025 G/                               | 2| 2| 2| 2| 2|                                                           |      L     |
    KG 79 LM                               | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicular Cell, Cyst                |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +                                                            |  58        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +                                                            |  59        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +                                                            |  57        |
      Epithelium, Hyperplasia              |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +                                                            |  59        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +                                                            |  60        |
      Atrophy                              |                                                                          |      1  3.0|
      Interstitial Cell, Hyperplasia       | 2     2  2  2                                                            |     26  1.8|
      Seminiferous Tubule, Atrophy         | 2  4  2                                                                  |     34  2.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |  58        |
      Pigmentation                         |                                                                          |     20  1.2|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +                                                            |  59        |
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      | 2     1                                                                  |      5  1.6|
      Mediastinal, Pigmentation            | 2  2                                                                     |     20  2.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |      6  2.2|
      Pancreatic, Pigmentation             |                                                                          |      7  1.9|
      Renal, Angiectasis                   |                                                                          |      1  2.0|
      Renal, Infiltration Cellular,        |                                                                          |            |
          Histiocyte                       |                                                                          |      1  2.0|
      Renal, Pigmentation                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |  56        |
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      3  1.3|
      Pigmentation                         | 1                                                                        |     28  1.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |  54        |
      Infiltration Cellular, Mast Cell     |       2                                                                  |      2  2.0|
      Infiltration Cellular, Histiocyte    | 2     3  3  2                                                            |     40  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  92                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 4|                                                           |            |
                             DAY ON TEST   | 4| 5| 1| 0| 7|                                                           |            |
                                           | 3| 0| 1| 9| 4|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3|                                                           |      A     |
    0.025 G/                               | 2| 2| 2| 2| 2|                                                           |      L     |
    KG 79 LM                               | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pigmentation                         | 2  3  1                                                                  |     42  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |  56        |
      Angiectasis                          |                                                                          |      1  2.0|
      Depletion Lymphoid                   |    2                                                                     |      5  1.8|
      Fibrosis                             |                                                                          |      3  2.3|
      Hematopoietic Cell Proliferation     | 2     2                                                                  |     35  2.2|
      Infiltration Cellular, Histiocyte    | 1     2                                                                  |     24  1.4|
      Pigmentation, Hemosiderin            | 2                                                                        |     35  1.9|
      Pigmentation                         | 2     2                                                                  |     33  1.8|
      Capsule, Cyst                        |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +                                                            |  50        |
      Depletion Lymphoid                   |       3                                                                  |      5  2.2|
      Hemorrhage                           |                                                                          |      1  2.0|
      Pigmentation                         |       1                                                                  |     25  1.1|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +                                                            |  36        |
      Galactocele                          |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |  60        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Metaplasia, Osseous                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |  60        |
      Costochondral Junction, Fibrosis     | 2                                                                        |      1  2.0|
      Costochondral Junction, Inflammation,|                                                                          |            |
           Chronic Active                  | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |  59        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |  60        |
      Atelectasis                          |                                                                          |     10  1.4|
      Congestion                           |                                                                          |      5  2.6|
      Edema                                |    3                                                                     |      9  2.0|
      Fibrosis                             |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      3  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  93                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 4|                                                           |            |
                             DAY ON TEST   | 4| 5| 1| 0| 7|                                                           |            |
                                           | 3| 0| 1| 9| 4|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3|                                                           |      A     |
    0.025 G/                               | 2| 2| 2| 2| 2|                                                           |      L     |
    KG 79 LM                               | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Infiltration Cellular, Histiocyte    |       2                                                                  |     46  1.7|
      Inflammation, Acute                  | 1  3     1                                                               |     13  1.8|
      Inflammation, Granulomatous          |                                                                          |     10  1.2|
      Mineralization                       |                                                                          |      3  1.3|
      Pigmentation                         | 1  1     2                                                               |     34  1.4|
      Pigmentation, Cholesterol            |                                                                          |      3  1.7|
      Alveolar Epithelium, Hyperplasia     | 1                                                                        |      6  1.7|
      Bronchiole, Hyperplasia              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |  60        |
      Fungus                               |                                                                          |      6  2.3|
      Inflammation, Acute                  |    2  1                                                                  |     18  2.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |  58        |
      Erosion                              |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   3        |
      Canal, Inflammation, Acute           |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                                            |  13        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Lens, Cataract                       |             2                                                            |      6  2.2|
      Retina, Atrophy                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +                                                            |  10        |
      Pigmentation                         |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |  60        |
      Nephropathy                          | 1     1                                                                  |     39  1.7|
      Pigmentation                         |                                                                          |      2  1.0|
      Cortex, Mineralization               |                                                                          |      3  1.7|
      Papilla, Mineralization              |             1                                                            |     15  1.1|
      Renal Tubule, Hyperplasia            |                                                                          |      1  1.0|
      Renal Tubule, Pigmentation           | 1     1                                                                  |     20  1.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  A  +  +  +                                                            |  55        |
      Calculus Gross Observation           |                                                                          |      1     |
      Calculus Micro Observation Only      |                                                                          |      2     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  94                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 3| 7| 6| 5| 4| 2| 7| 4| 7| 4| 7| 7| 7| 5| 5| 3| 7| 6| 5| 3| 2|             
                             DAY ON TEST   | 3| 3| 3| 7| 8| 3| 2| 7| 5| 5| 3| 5| 3| 5| 3| 3| 3| 7| 7| 3| 3| 9| 7| 1| 6|             
                                           | 8| 9| 9| 6| 3| 4| 0| 6| 7| 4| 8| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 0| 6| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.05 G/K                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    G 79 HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  A     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Parasite                             |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  A     +  +  +        +  +     +     +  +  +        +  +  +     +  M|             
      Parasite                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  A     +  +  +        +  +     +     +  +  +        A  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A     +  +  +        +  +     +     +  +  M        A  +  +     +  +|             
      Pigmentation                         | 1  1        1  2           1  1     1     1  1              1  1         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A     +  +  +        +  +     +     +  +  +        A  +  +     +  +|             
      Pigmentation                         | 1                                                           1  1         |             
      Lymphoid Tissue, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A     +  +  +        +  +     +     +  +  +        A  +  +     A  +|             
      Pigmentation                         | 1  1        1                 1           1     1                        |             
      Lymphoid Tissue, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Angiectasis                          |                2                                                         |             
      Basophilic Focus                     | X  X        X  X  X                 X     X  X           X     X     X   |             
      Clear Cell Focus                     | X                             X     X        X                           |             
      Congestion                           |                                                                          |             
      Degeneration, Cystic                 |                                                             2            |             
      Eosinophilic Focus                   | X                                   X                       X  X         |             
      Fatty Change, Focal                  |                1  1        1                                2            |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Granulomatous          |    1                          1     1        2  1           1            |             
      Mixed Cell Focus                     |                               X           X     X           X            |             
      Necrosis                             |                                                                2         |             
      Pigmentation                         | 1  2        1  2              2     2     2  2  2           2  1        1|             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               |    2              2                          2                          2|             
                                            __________________________________________________________________________|             
   Mesentery                               |             +  +                                                         |             
      Artery, Necrosis, Fibrinoid          |             3                                                            |             
      Fat, Hemorrhage                      |                                                                          |             
      Fat, Necrosis                        |                4                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +        +  +     +     +  +  M        +  +  +     +  +|             
      Hyperplasia                          |                                                                          |             
      Acinus, Hyperplasia                  | 2              3  2           2     2     2                              |             
      Artery, Necrosis, Fibrinoid          |             3                                                            |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 3| 7| 6| 5| 4| 2| 7| 4| 7| 4| 7| 7| 7| 5| 5| 3| 7| 6| 5| 3| 2|             
                             DAY ON TEST   | 3| 3| 3| 7| 8| 3| 2| 7| 5| 5| 3| 5| 3| 5| 3| 3| 3| 7| 7| 3| 3| 9| 7| 1| 6|             
                                           | 8| 9| 9| 6| 3| 4| 0| 6| 7| 4| 8| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 0| 6| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.05 G/K                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    G 79 HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Artery, Necrosis, Fibrinoid          |             2                                                            |             
      Fat, Proliferation                   |                                     1     2  2  1           1            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Acanthosis                           | 2                 2        1        2     2     1              2     1   |             
      Hyperkeratosis                       | 3                          2                                             |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  A     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Erosion                              |                                                                1         |             
      Fibrosis                             | 2  2        2     2           1     2     2  2  2           2  2        1|             
      Hemorrhage                           |                   1        2                                             |             
      Hyperplasia                          |             1                             1     2           2  2        2|             
      Inflammation, Acute                  |             2              1                                            1|             
      Metaplasia                           | 1  1        2     1                 1     1  2  1           2  1        2|             
      Mineralization                       | 1                                                                        |             
      Pigmentation                         |                1              1     2     1  1                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Bacterium                            |                                                                          |             
      Cardiomyopathy                       |    2  2        3  2           2     2     2  2  2           2  2        2|             
      Pigmentation                         |                                              1                           |             
      Artery, Necrosis, Fibrinoid          |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Hyperplasia                          |                                                                          |             
      Infarct                              |                                                                4         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Hyperplasia                          |                                              1              2            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +        +  +     +     +  +  M        +  +  +     +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +     +  +  M        M  +     M     +  +  +        +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  M|             
      Pars Distalis, Angiectasis           |    2                                            2           2            |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                2                          2  2                           |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  A     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      C-Cell, Hyperplasia                  |                                                 2              2         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 3| 7| 6| 5| 4| 2| 7| 4| 7| 4| 7| 7| 7| 5| 5| 3| 7| 6| 5| 3| 2|             
                             DAY ON TEST   | 3| 3| 3| 7| 8| 3| 2| 7| 5| 5| 3| 5| 3| 5| 3| 3| 3| 7| 7| 3| 3| 9| 7| 1| 6|             
                                           | 8| 9| 9| 6| 3| 4| 0| 6| 7| 4| 8| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 0| 6| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.05 G/K                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    G 79 HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Necrosis                             |                2                                            2            |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Epithelium, Hyperplasia              |                                              2                           |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Infarct                              |                                                                          |             
      Interstitial Cell, Hyperplasia       |       2     1     2        2  1              2                 2     1   |             
      Seminiferous Tubule, Atrophy         | 2  4           2  2           2     2     2     2              2         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Pigmentation                         | 2  1           1              2     1     1  2              1  1         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Axillary, Angiectasis                |                                                                          |             
      Axillary, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Histiocyte                       |                                                                          |             
      Lumbar, Pigmentation                 |                                                                          |             
      Mediastinal, Angiectasis             |                                                                          |             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
          Proliferation                    |                                           2                              |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      | 2  1           2              2     2     1  2              2            |             
      Mediastinal, Pigmentation            | 1  2        1  2              1     1     1  1              1            |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                                          |             
      Pancreatic, Pigmentation             |             2                                                           1|             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                                                          |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Bacterium                            |                                                                          |             
      Degeneration, Cystic                 |    2                                                                     |             
      Infiltration Cellular, Histiocyte    |                2              2     1     1  2                           |             
      Pigmentation                         |    1        1  1              2           1  1                       1   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +  +        +  +     +     +  +  +        M  +  +     +  +|             
      Bacterium                            |                                                                          |             
      Infiltration Cellular, Mast Cell     |                                                             2            |             
      Infiltration Cellular, Histiocyte    | 3  2           3  3           3     3     3  3  2           3  3        2|             
      Mineralization                       |                                     2     1                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  97                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 3| 7| 6| 5| 4| 2| 7| 4| 7| 4| 7| 7| 7| 5| 5| 3| 7| 6| 5| 3| 2|             
                             DAY ON TEST   | 3| 3| 3| 7| 8| 3| 2| 7| 5| 5| 3| 5| 3| 5| 3| 3| 3| 7| 7| 3| 3| 9| 7| 1| 6|             
                                           | 8| 9| 9| 6| 3| 4| 0| 6| 7| 4| 8| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 0| 6| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.05 G/K                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    G 79 HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         | 2  2        2  2              2     2     2  2  2           2  2     1   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Depletion Lymphoid                   |                            2                                             |             
      Fibrosis                             |                                                             2            |             
      Hematopoietic Cell Proliferation     |    2           2  2           2     2     2  2  2           2  3        2|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 2  2           2  2           2     1     2  2  2           2            |             
      Inflammation, Granulomatous          |                                                                          |             
      Necrosis                             |             3                                                            |             
      Pigmentation, Hemosiderin            | 1  2        2  2           2  2     1     2  2  2        2  2           2|             
      Pigmentation                         | 1  1           2              2     1     2  2  2           2           1|             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  +  +        +  +     +     +  +  +        +  M  +     +  +|             
      Depletion Lymphoid                   |             2  2                                                         |             
      Ectopic Parathyroid Gland            |                                                                          |             
      Pigmentation                         | 1  1           1           1  1     1     1  1  1        1     1        1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +     +  +  M        +  +     +     +  +  +        M  +  +     +  +|             
      Galactocele                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Hemorrhage                           |                2                                                         |             
      Hyperkeratosis                       |                                                             3            |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Bacterium                            |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Atelectasis                          |                            2  2                                         2|             
      Bacterium                            |                                                                          |             
      Congestion                           |                            1                             3           2   |             
      Edema                                |                   2                                                      |             
      Hemorrhage                           |       1        1                                                         |             
      Infiltration Cellular, Histiocyte    | 2  2  1        2  2           2     2     2  2  2        2  2  1     2  2|             
      Inflammation, Acute                  |                   3        3  2                 2                        |             
      Inflammation, Granulomatous          | 1  1           2                    2                    1           1   |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  98                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 3| 7| 6| 5| 4| 2| 7| 4| 7| 4| 7| 7| 7| 5| 5| 3| 7| 6| 5| 3| 2|             
                             DAY ON TEST   | 3| 3| 3| 7| 8| 3| 2| 7| 5| 5| 3| 5| 3| 5| 3| 3| 3| 7| 7| 3| 3| 9| 7| 1| 6|             
                                           | 8| 9| 9| 6| 3| 4| 0| 6| 7| 4| 8| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 0| 6| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.05 G/K                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    G 79 HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         | 1  1  2        2  2        3  2              1  2        2  1  2     1  2|             
      Pigmentation, Cholesterol            |                                     2                                    |             
      Alveolar Epithelium, Hyperplasia     | 1                                         2                              |             
      Artery, Mediastinum, Necrosis,       |                                                                          |             
          Fibrinoid                        |             2                                                            |             
      Bronchiole, Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                          2               |             
      Bronchus, Inflammation, Chronic      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Erosion                              |                                                                          |             
      Fungus                               |    2                                                        3            |             
      Inflammation, Acute                  |    3        3  3  2                                         3            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Acute                  |                   2                                                      |             
      Metaplasia, Squamous                 |                   1                                                      |             
      Pigmentation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +              +        +   |             
      Lens, Cataract                       |                                                                      2   |             
      Retina, Atrophy                      |                                                             2            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                              +              +        +   |             
      Inflammation, Chronic Active         |                                                             2            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Abscess                              |                                                                          |             
      Bacterium                            |                                                                          |             
      Cyst                                 |                                                                          |             
      Nephropathy                          | 2  2           2  2           2     2     2  2  2           2  2         |             
      Cortex, Mineralization               |                                                                          |             
      Papilla, Mineralization              |    1                                         1                          1|             
      Renal Tubule, Pigmentation           | 1  2                          1     1     1  1                 1        1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  A     +  +  +        +  +     +     +  +  +        +  +  +     +  +|             
      Calculus Gross Observation           |                                                                          |             
      Calculus Micro Observation Only      |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  99                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 5| 4| 6| 6| 5| 5| 4| 7| 7| 7| 5| 2| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 9| 1| 5| 7| 0| 7| 1| 4| 1| 5| 3| 3| 2| 8| 6| 3| 1| 1| 0| 1| 3| 3| 3| 5| 3|             
                                           | 0| 7| 7| 6| 1| 5| 2| 0| 5| 7| 8| 8| 2| 6| 1| 8| 1| 4| 9| 8| 8| 9| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.05 G/K                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    G 79 HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  M     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +        +  +  +  +  A     +  +  +  +  +  +  A  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A        A  +  +  +  A     +  +  +  +  +  +  A  +  +  +  +  +  +     +|             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +        +  +  +  +  A     +  +  +  +  +  +  A  +  +  +  +  +  +     +|             
      Parasite                             | 1                             2                                         2|             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  A        A  +  +  +  A     +  +  +  +  +  +  A  +  +  +  +  +  +     +|             
      Parasite                             |                                                                   1      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A        A  +  +  +  M     +  +  +  +  +  +  A  +  +  +  +  +  +     +|             
      Pigmentation                         | 1              1     1        1  1        1  1        1     1  1  1     1|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +        +  +  +  +  A     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Pigmentation                         |                                                                          |             
      Lymphoid Tissue, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A        A  +  +  +  A     +  +  M  +  +  +  A  +  +  +  +  +  +     +|             
      Pigmentation                         |                      1        1              1        1                  |             
      Lymphoid Tissue, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |    X        X  X  X  X  X     X  X  X  X     X           X  X     X     X|             
      Clear Cell Focus                     |                      X        X  X                                       |             
      Congestion                           |                                                                          |             
      Degeneration, Cystic                 |                2                             2                           |             
      Eosinophilic Focus                   |                                     X        X                    X      |             
      Fatty Change, Focal                  |    1        1        2           1     1  1     2     1  1               |             
      Hemorrhage                           |                                                    4                     |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Granulomatous          |                               1              1              2            |             
      Mixed Cell Focus                     |                               X                                          |             
      Necrosis                             |                1                                                         |             
      Pigmentation                         | 1              1     1        2  2  1  1     1  1     1     2  1  1     1|             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               |                      2        2     2                 2  2        2      |             
                                            __________________________________________________________________________|             
   Mesentery                               | +              +                                                         |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
      Fat, Hemorrhage                      | 3                                                                        |             
      Fat, Necrosis                        | 2                                                                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia                          |                                                             2            |             
      Acinus, Hyperplasia                  |    2                             2     2     1                           |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 100                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 5| 4| 6| 6| 5| 5| 4| 7| 7| 7| 5| 2| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 9| 1| 5| 7| 0| 7| 1| 4| 1| 5| 3| 3| 2| 8| 6| 3| 1| 1| 0| 1| 3| 3| 3| 5| 3|             
                                           | 0| 7| 7| 6| 1| 5| 2| 0| 5| 7| 8| 8| 2| 6| 1| 8| 1| 4| 9| 8| 8| 9| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.05 G/K                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    G 79 HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
      Fat, Proliferation                   |                               1        1                                 |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +        +  +  +  +  A     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Acanthosis                           | 2  2                 2        1        2     2  2                        |             
      Hyperkeratosis                       | 2  2                 2                 2     2  3                 3      |             
      Inflammation, Chronic Active         |                                           1                              |             
      Necrosis                             |                                           1                              |             
      Pigmentation                         |                                                                1         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  M        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Erosion                              | 2                                   1  1  1           1                  |             
      Fibrosis                             | 2           1  2     2  1     1        2     2  2     1     1  1  2      |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          | 2                    2        1        2              1           1      |             
      Inflammation, Acute                  |                                        2  2           2                  |             
      Metaplasia                           | 2           1  2     2        1        1  1  1        1        1  1      |             
      Mineralization                       |                                                                          |             
      Pigmentation                         | 1                    1        1              1        1        1         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Bacterium                            |                                                 3                        |             
      Cardiomyopathy                       | 2  2           2  2  2  2        2  2        2  2     2     1  2  2     2|             
      Pigmentation                         |                                                                   1      |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia                          |                                                                          |             
      Infarct                              |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia                          |                   1           1     2              2        1            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +        +  M  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Pars Distalis, Angiectasis           |                                  2              3  2  2     1  3         |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           | 2                             2  2     2              2        2         |             
      Pars Intermedia, Cyst                |                                  X                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +        +  +  A  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      C-Cell, Hyperplasia                  |                1     1        1                    1                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 101                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 5| 4| 6| 6| 5| 5| 4| 7| 7| 7| 5| 2| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 9| 1| 5| 7| 0| 7| 1| 4| 1| 5| 3| 3| 2| 8| 6| 3| 1| 1| 0| 1| 3| 3| 3| 5| 3|             
                                           | 0| 7| 7| 6| 1| 5| 2| 0| 5| 7| 8| 8| 2| 6| 1| 8| 1| 4| 9| 8| 8| 9| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.05 G/K                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    G 79 HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +        +  +  +  M  +     +  +  +  M  +  +  +  +  +  +  +  +  +     +|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Epithelium, Hyperplasia              | 2                 1              1  2  1                                 |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Infarct                              |                   4                                                      |             
      Interstitial Cell, Hyperplasia       | 1  2        1  1  2  2        1     1                 2  2               |             
      Seminiferous Tubule, Atrophy         | 2              4  2  3        2  2  2        2        2  2  2  2  2     2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Pigmentation                         | 1              1     1        1  1  1        1  2     1     1  1  1     1|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Axillary, Angiectasis                |                                                                          |             
      Axillary, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Histiocyte                       |                                                                          |             
      Lumbar, Pigmentation                 |                                                                          |             
      Mediastinal, Angiectasis             |                                     2                                    |             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
          Proliferation                    |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                3  1  2        1     2  2              1  2  2  2  2     3|             
      Mediastinal, Pigmentation            | 1              2  1  1              2                       1  1  1     2|             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |    3                                2                             1      |             
      Pancreatic, Pigmentation             |                                                                          |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                                                          |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M        +  +  +  M  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Bacterium                            |                                                 1                        |             
      Degeneration, Cystic                 |                                                                          |             
      Infiltration Cellular, Histiocyte    |                2  2           1              2              1     2     1|             
      Pigmentation                         |                   1                          1                    1      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +        +  +  +  +  A     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Bacterium                            |                                                 1                        |             
      Infiltration Cellular, Mast Cell     |                      2                                                   |             
      Infiltration Cellular, Histiocyte    | 2  2        2  2  1  2        3  3  2  2     3  2  1  2     3  3        2|             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 102                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 5| 4| 6| 6| 5| 5| 4| 7| 7| 7| 5| 2| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 9| 1| 5| 7| 0| 7| 1| 4| 1| 5| 3| 3| 2| 8| 6| 3| 1| 1| 0| 1| 3| 3| 3| 5| 3|             
                                           | 0| 7| 7| 6| 1| 5| 2| 0| 5| 7| 8| 8| 2| 6| 1| 8| 1| 4| 9| 8| 8| 9| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.05 G/K                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    G 79 HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         | 2  2           2     1        2  2  2  2  2  2  1     1     2  2        2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +        +  +  +  +  +     +  +  +  +  +  +  A  +  +  +  +  +  +     +|             
      Depletion Lymphoid                   |    2                                                                     |             
      Fibrosis                             | 2                                                                        |             
      Hematopoietic Cell Proliferation     | 2  2                 2        2  2        2        2              2     2|             
      Hemorrhage                           |                                     3                                    |             
      Infiltration Cellular, Histiocyte    |    2                 2        2  1  2  1     2     2  1     2  2  1     2|             
      Inflammation, Granulomatous          |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            | 1              1     2        2  2  2     2  2              2  1  1     2|             
      Pigmentation                         |                1     2        2  1  2        2        1     1  2  1     2|             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +        M  M  +  +  +     +  +  +  +  M  M  M  +  +  +  +  +  +     +|             
      Depletion Lymphoid                   |                                  2                    2                  |             
      Ectopic Parathyroid Gland            |                                        2                                 |             
      Pigmentation                         | 1                                1                    2     1  1  1     1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +        +  M  M  M  +     M  M  M  +  +  M  +  +  +  M  M  +  +     M|             
      Galactocele                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +        +  +  +  M  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hemorrhage                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Necrosis                             |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Bacterium                            |                                                 2                        |             
      Metaplasia, Osseous                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Atelectasis                          | 2              1                    3     2                       2     2|             
      Bacterium                            |                                                                          |             
      Congestion                           |                                                                          |             
      Edema                                |    2              2                                                      |             
      Hemorrhage                           |             2                                         2                  |             
      Infiltration Cellular, Histiocyte    | 1  1        1  1  2           2  2  2  1  2  2  2     2  2  1     2     2|             
      Inflammation, Acute                  |    4              3                                3                     |             
      Inflammation, Granulomatous          |                                     1     1           1                  |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 103                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 4| 5| 4| 6| 6| 5| 5| 4| 7| 7| 7| 5| 2| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 9| 1| 5| 7| 0| 7| 1| 4| 1| 5| 3| 3| 2| 8| 6| 3| 1| 1| 0| 1| 3| 3| 3| 5| 3|             
                                           | 0| 7| 7| 6| 1| 5| 2| 0| 5| 7| 8| 8| 2| 6| 1| 8| 1| 4| 9| 8| 8| 9| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.05 G/K                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    G 79 HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         |    2              1  2  2     1  2  3  2  2  2  1     2  2  1  1  1     2|             
      Pigmentation, Cholesterol            |                   1              1                                       |             
      Alveolar Epithelium, Hyperplasia     |                                  2     2                                 |             
      Artery, Mediastinum, Necrosis,       |                                                                          |             
          Fibrinoid                        |                                                                          |             
      Bronchiole, Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
      Bronchus, Inflammation, Chronic      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +        M  M  M  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Erosion                              |                                                                          |             
      Fungus                               |                               2  2                             3        2|             
      Inflammation, Acute                  |    2                          2  2                 4     2  1  3  3     3|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Erosion                              |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Metaplasia, Squamous                 |    1                                                                     |             
      Pigmentation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                             +           +                 +            |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                             +                             +            |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +        +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Abscess                              |                                                 2                        |             
      Bacterium                            |                                                 2                        |             
      Cyst                                 |             X                                                            |             
      Nephropathy                          | 3              1  2           2  2  2        1        1     2  1  1      |             
      Cortex, Mineralization               |                                           2                              |             
      Papilla, Mineralization              |                   1                                      1               |             
      Renal Tubule, Pigmentation           |                2  1           1  1           1           1  1  2  1     1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +        +  +  +  +  A     +  +  +  +  +  +  A  +  +  +  +  +  +     +|             
      Calculus Gross Observation           |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 104                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 4| 4| 7| 7| 7| 6| 4| 7| 7| 6| 2| 2| 7| 6| 5| 2| 2| 4| 4| 7| 6| 0|             
                             DAY ON TEST   | 3| 3| 7| 6| 0| 3| 3| 0| 6| 5| 3| 3| 1| 6| 4| 4| 1| 7| 2| 5| 5| 5| 3| 4| 6|             
                                           | 9| 8| 6| 5| 5| 9| 9| 8| 2| 8| 9| 9| 2| 4| 8| 0| 2| 6| 9| 1| 8| 8| 9| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.05 G/K                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    G 79 HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  M        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Pigmentation                         |                                                                   1      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Parasite                             |    2                                                                     |             
      Pigmentation                         |                                                                   1      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Parasite                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Pigmentation                         | 1  1        1  1     1  1     1  1  1        1  1                    1   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Pigmentation                         |                                                                          |             
      Lymphoid Tissue, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +  +  +  +  +     +  +  +  +  A  +  +     +  +        +  +  +|             
      Pigmentation                         | 1  1                                1                                1   |             
      Lymphoid Tissue, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X  X     X     X  X  X  X     X              X  X                 X  X   |             
      Clear Cell Focus                     | X        X  X  X        X     X              X                           |             
      Congestion                           |                                           2                              |             
      Degeneration, Cystic                 |                   2                                                      |             
      Eosinophilic Focus                   |    X                    X        X        X                       X  X   |             
      Fatty Change, Focal                  |                2     1  2           2           2                        |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |                      X                                                   |             
      Inflammation, Granulomatous          |    2                          3                 2                 2      |             
      Mixed Cell Focus                     | X                                            X  X                        |             
      Necrosis                             |                         1     1                                   1      |             
      Pigmentation                         | 1  2        1  1  1  1  1     2  1           1  1        1        2  1   |             
      Thrombosis                           |                                  2                                       |             
      Bile Duct, Hyperplasia               | 1                                                                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                       +                  |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
      Fat, Hemorrhage                      |                                                                          |             
      Fat, Necrosis                        |                                                       2                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Hyperplasia                          |                                                                          |             
      Acinus, Hyperplasia                  |                3        2     3  2  2                                    |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                   +      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 105                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 4| 4| 7| 7| 7| 6| 4| 7| 7| 6| 2| 2| 7| 6| 5| 2| 2| 4| 4| 7| 6| 0|             
                             DAY ON TEST   | 3| 3| 7| 6| 0| 3| 3| 0| 6| 5| 3| 3| 1| 6| 4| 4| 1| 7| 2| 5| 5| 5| 3| 4| 6|             
                                           | 9| 8| 6| 5| 5| 9| 9| 8| 2| 8| 9| 9| 2| 4| 8| 0| 2| 6| 9| 1| 8| 8| 9| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.05 G/K                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    G 79 HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
      Fat, Proliferation                   |                2  3                 1        2                    1  1   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Acanthosis                           |                3  2  2  1     2     2        2  2                 2  1   |             
      Hyperkeratosis                       |                2     2  3     3              3  1                        |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Erosion                              |                      2  1        2  1           2     2              1   |             
      Fibrosis                             |    1        2  2  2  2  2     2  2           2  2                 2      |             
      Hemorrhage                           |                                                 2     1                 1|             
      Hyperplasia                          |    1     2  2  1  2  2  1        2  2        1  2                    1   |             
      Inflammation, Acute                  |    1        1                       1                 2                  |             
      Metaplasia                           |    1     1  1  2  2  1  1     1     1           2                 1  1   |             
      Mineralization                       |                                                                          |             
      Pigmentation                         | 1  1           2     1              1                             1  1   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Bacterium                            |                                                                          |             
      Cardiomyopathy                       | 2  2     2  2  2  2  2        2  2        2  2  2     2  1           2   |             
      Pigmentation                         |                                                                          |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Hyperplasia                          |                         2        1           2                           |             
      Infarct                              |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +  +  +  +  +  +     +  +  +  +  +  +  M     +  +        +  +  +|             
      Hyperplasia                          |                   2  2  2        2  2        2                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  +  +  M  +     +  +  +  M  M  +  +     M  M        +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  +  +  M     +  +  +  M  +  +  +     +  +        +  +  +|             
      Pars Distalis, Angiectasis           |    2                 3                                                   |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |             2                    2                                3      |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      C-Cell, Hyperplasia                  |    2              1                                               1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 106                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 4| 4| 7| 7| 7| 6| 4| 7| 7| 6| 2| 2| 7| 6| 5| 2| 2| 4| 4| 7| 6| 0|             
                             DAY ON TEST   | 3| 3| 7| 6| 0| 3| 3| 0| 6| 5| 3| 3| 1| 6| 4| 4| 1| 7| 2| 5| 5| 5| 3| 4| 6|             
                                           | 9| 8| 6| 5| 5| 9| 9| 8| 2| 8| 9| 9| 2| 4| 8| 0| 2| 6| 9| 1| 8| 8| 9| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.05 G/K                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    G 79 HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +     M  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  M|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Epithelium, Hyperplasia              |                                  2                                       |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Infarct                              |                                                                          |             
      Interstitial Cell, Hyperplasia       | 2  2     1  2  1     1  1     2  2           1  2                 2      |             
      Seminiferous Tubule, Atrophy         | 2              2  3  2  2     2  3  2        2  2                 2  2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Pigmentation                         | 2  1        1  1  1  1  1     1  1  1        1  1                 1  1   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Axillary, Angiectasis                |                2                                                         |             
      Axillary, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                2                                                         |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Histiocyte                       |                                  3                                       |             
      Lumbar, Pigmentation                 |                                  2                                       |             
      Mediastinal, Angiectasis             |                                                                          |             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
          Proliferation                    |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |    1     1     1  1     2     1  2           2  1                 1      |             
      Mediastinal, Pigmentation            |    1           1  1     1        1           1                    1      |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                   1                                                      |             
      Pancreatic, Pigmentation             |                                                                          |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       | 3                                                                        |             
      Renal, Pigmentation                  | 2                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  M        +  +  +|             
      Bacterium                            |                                                                          |             
      Degeneration, Cystic                 |                                  2              3                        |             
      Infiltration Cellular, Histiocyte    | 2              2  1  1  1        1           2                       1   |             
      Pigmentation                         | 1              2  1  1  1                    1                       1   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Bacterium                            |                                                                          |             
      Infiltration Cellular, Mast Cell     |                                                 2                        |             
      Infiltration Cellular, Histiocyte    | 3  2     2     3  3  3  3     3  2  3        3  3                 3  2   |             
      Mineralization                       | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 107                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 4| 4| 7| 7| 7| 6| 4| 7| 7| 6| 2| 2| 7| 6| 5| 2| 2| 4| 4| 7| 6| 0|             
                             DAY ON TEST   | 3| 3| 7| 6| 0| 3| 3| 0| 6| 5| 3| 3| 1| 6| 4| 4| 1| 7| 2| 5| 5| 5| 3| 4| 6|             
                                           | 9| 8| 6| 5| 5| 9| 9| 8| 2| 8| 9| 9| 2| 4| 8| 0| 2| 6| 9| 1| 8| 8| 9| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.05 G/K                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    G 79 HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         | 2  1        2  2  2  2  2     2     2  2  2  2  2        2        2  2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Depletion Lymphoid                   |                      2                                2  2              2|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |    2     2  2        3  3     2                 1                    2   |             
      Hemorrhage                           |                                  2                                       |             
      Infiltration Cellular, Histiocyte    |    2           2     2  1     2              2  2                 2  2   |             
      Inflammation, Granulomatous          |    1                                                                     |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |    2        2  2     2  2     2           2  2           2        2  2   |             
      Pigmentation                         |    2        2  2     2  2     2              2  1                 2  2   |             
      Thrombosis                           |                                  4                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  M  +  +  +  +     +  +  M  +  +  +  +     +  +        +  +  +|             
      Depletion Lymphoid                   |                      3           3           2                           |             
      Ectopic Parathyroid Gland            |                                                                          |             
      Pigmentation                         | 1  1           1  1  1  1        2           1  1        1        1      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +  +  +  +  M     +  +  M  +  +  +  M     +  +        M  M  M|             
      Galactocele                          |                      X                                                   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Bacterium                            |                                                                          |             
      Metaplasia, Osseous                  |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Atelectasis                          | 2  1                    2           2     2                              |             
      Bacterium                            |                      2                                                   |             
      Congestion                           |                                                       3  3              3|             
      Edema                                |             1                       2  2  2           2  2              2|             
      Hemorrhage                           |                                        2  2                          2  2|             
      Infiltration Cellular, Histiocyte    | 3  2           2     2  3     2  2  2  2  2  2  2     2  2        2  1   |             
      Inflammation, Acute                  |                      4                                   1           3   |             
      Inflammation, Granulomatous          | 1           1           2     1        2  2  1  2     2  2              1|             
      Necrosis                             |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 108                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 4| 4| 7| 7| 7| 6| 4| 7| 7| 6| 2| 2| 7| 6| 5| 2| 2| 4| 4| 7| 6| 0|             
                             DAY ON TEST   | 3| 3| 7| 6| 0| 3| 3| 0| 6| 5| 3| 3| 1| 6| 4| 4| 1| 7| 2| 5| 5| 5| 3| 4| 6|             
                                           | 9| 8| 6| 5| 5| 9| 9| 8| 2| 8| 9| 9| 2| 4| 8| 0| 2| 6| 9| 1| 8| 8| 9| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.05 G/K                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    G 79 HM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         | 2  1        1  1        2     1  1  2  2  2  1  1     2  2        1  1  1|             
      Pigmentation, Cholesterol            | 2                    1                                                   |             
      Alveolar Epithelium, Hyperplasia     |                                              2                           |             
      Artery, Mediastinum, Necrosis,       |                                                                          |             
          Fibrinoid                        |                                                                          |             
      Bronchiole, Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
      Bronchus, Inflammation, Chronic      |                                        3                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  M|             
      Erosion                              |                                                 1                        |             
      Fungus                               |    2                                                                     |             
      Inflammation, Acute                  |    2                 2        2  2  2           3                    4   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Erosion                              |                                                                      2   |             
      Inflammation, Acute                  |                      1                                               2   |             
      Metaplasia, Squamous                 |                                                                      1   |             
      Pigmentation                         |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |    +                                                                     |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +                    +                  |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                  +                                       |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +        +  +  +|             
      Abscess                              |                                                                          |             
      Bacterium                            |                                                                          |             
      Cyst                                 |                                                                          |             
      Nephropathy                          | 2  2           2  1  2        2  1           2  1                 2  1   |             
      Cortex, Mineralization               |                                                                          |             
      Papilla, Mineralization              |                1              1                 1        1               |             
      Renal Tubule, Pigmentation           | 2  1           2  2  2           1  1        1  1                 2      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +  +  +  M     +  +  +  +  +  +  +     +  +        +  +  +|             
      Calculus Gross Observation           |                                                                         X|             
      Calculus Micro Observation Only      |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 109                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 5| 5| 4|                                                           |            |
                             DAY ON TEST   | 3| 5| 7| 7| 6|                                                           |            |
                                           | 9| 8| 6| 6| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4|                                                           |      A     |
    0.05 G/K                               | 8| 8| 8| 8| 8|                                                           |      L     |
    G 79 HM                                | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +           +                                                            |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +           +                                                            |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +           +                                                            |  55        |
      Pigmentation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +           +                                                            |  57        |
      Parasite                             |                                                                          |      4  1.8|
      Pigmentation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +           +                                                            |  54        |
      Parasite                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +           +                                                            |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +           +                                                            |  53        |
      Pigmentation                         | 1                                                                        |     36  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +           +                                                            |  57        |
      Pigmentation                         |                                                                          |      3  1.0|
      Lymphoid Tissue, Hyperplasia         |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +           +                                                            |  51        |
      Pigmentation                         |                                                                          |     14  1.0|
      Lymphoid Tissue, Hyperplasia         |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +           +                                                            |  60        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     | X           X                                                            |     40     |
      Clear Cell Focus                     |                                                                          |     14     |
      Congestion                           |                                                                          |      1  2.0|
      Degeneration, Cystic                 |                                                                          |      4  2.0|
      Eosinophilic Focus                   | X                                                                        |     14     |
      Fatty Change, Focal                  |             1                                                            |     19  1.4|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hepatodiaphragmatic Nodule           |             X                                                            |      2     |
      Inflammation, Granulomatous          | 2                                                                        |     14  1.6|
      Mixed Cell Focus                     |                                                                          |      8     |
      Necrosis                             |                                                                          |      5  1.2|
      Pigmentation                         | 1                                                                        |     41  1.3|
      Thrombosis                           |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |                                                                          |     11  1.9|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  3.0|
      Fat, Hemorrhage                      |                                                                          |      1  3.0|
      Fat, Necrosis                        |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +           +                                                            |  59        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 110                                                               
NTP Experiment-Test: 05047-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       TITANOCENE DICHLORIDE                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 10:11:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 5| 5| 4|                                                           |            |
                             DAY ON TEST   | 3| 5| 7| 7| 6|                                                           |            |
                                           | 9| 8| 6| 6| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4|                                                           |      A     |
    0.05 G/K                               | 8| 8| 8| 8| 8|                                                           |      L     |
    G 79 HM                                | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      1  2.0|
      Acinus, Hyperplasia                  | 2                                                                        |     16  2.1|
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | M           +                                                            |  59        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +           +                                                            |  60        |
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  2.0|
      Fat, Proliferation                   | 1                                                                        |     14  1.4|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +           +                                                            |  59        |
      Acanthosis                           |             2                                                            |     26  1.8|
      Hyperkeratosis                       | 2           2                                                            |     17  2.3|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Necrosis                             |                                                                          |      1  1.0|
      Pigmentation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +           +                                                            |  58        |
      Erosion                              |                                                                          |     13  1.4|
      Fibrosis                             | 2                                                                        |     37  1.8|
      Hemorrhage                           |                                                                          |      5  1.4|
      Hyperplasia                          |                                                                          |     24  1.6|
      Inflammation, Acute                  |                                                                          |     10  1.5|
      Metaplasia                           | 2           1                                                            |     36  1.3|
      Mineralization                       |                                                                          |      1  1.0|
      Pigmentation                         | 1                                                                        |     19  1.1|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +           +                                                            |  60        |
      Bacterium                            |                                                                          |      1  3.0|
      Cardiomyopathy                       | 2                                                                        |     43  2.0|
      Pigmentation                         |                                                                          |      2  1.0|
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +           +                                                            |  60        |
                                            ______________