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TDMS Study 91005-07 Pathology Tables

NTP  EXP/TEST: 91005-07                            METHYLENE BLUE TRIHYDRATE                                      PAGE: 1
TEST TYPE: CHRONIC                              INITIAL AND CURRENT BODY WEIGHT                                   DATE: 03/25/05
ROUTE: GAVAGE                                                                                                     TIME: 09:58:29

                                                         EIS REPORT 03


       FACILITY:  Southern Research Institute

       NTP C#:  91005C

       CONTRACT NUMBER:  N01-ES-05451

       CAS NUMBER:  7220-79-3

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 91005-07                            METHYLENE BLUE TRIHYDRATE                                      PAGE: 2
TEST TYPE: CHRONIC                              INITIAL AND CURRENT BODY WEIGHT                                   DATE: 03/25/05
ROUTE: GAVAGE                                               EISRPT03                                              TIME: 09:58:29
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 SPECIES-STRAIN: F 344-RATS                 SEX: FEMALE      WEEK ON DOSE: 106    FIRST DOSE: 06/26/00
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                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0 MG/KG            50     95.6    6.5        35    334.6   30.5                     35    238.9   30.4

 5 MG/KG            50     96.2    6.7        32    339.9   30.3       101.5         32    243.0   30.5

 25 MG/KG           50     97.3    7.7        34    304.8   26.0        91.0         34    206.7   25.0

 50 MG/KG           50     96.2    6.9        35    294.4   24.2        87.9         35    197.1   23.2




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 SPECIES-STRAIN: F 344-RATS                 SEX: MALE        WEEK ON DOSE: 106    FIRST DOSE: 06/26/00
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                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0 MG/KG            50    110.5    9.2        29    500.1   49.5                     29    387.5   49.6

 5 MG/KG            50    109.4    8.0        33    504.1   33.2       100.7         33    394.6   30.9

 25 MG/KG           50    108.9    8.0        39    456.2   35.3        91.2         39    347.7   32.5

 50 MG/KG           50    109.8    7.9        30    440.1   38.3        88.0         30    329.3   36.1

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