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TDMS Study 91005-07 Pathology Tables

                                                                                                                                   
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: Southern Research Inst                         METHYLENE BLUE TRIHYDRATE                                       DATE: 03/25/05  
EXPERIMENT: 91005 TEST: 07                                                                                        TIME: 10:00:56    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: GAVAGE                                                 NTP:  C91005C     
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: SOUTHERN RESEARCH INSTITUTE                      METHYLENE BLUE TRIHYDRATE                                   DATE: 03/25/05    
EXPERIMENT: 91005 TEST: 07                                                                                        TIME: 10:11:43    
SPECIES: RATS, FISCHER 344                                                                                                          
TEST TYPE: TWO YEAR                                 ROUTE: ORAL GAVAGE                                            NTP:  91005C      
CONT: N01-ES-05451                                                                                                CAS: 7220-79-3    
                                                                                                                                   
                                                                                                                                    
                             MEAN BODY WEIGHTS AND SURVIVAL OF MALE RATS IN THE                                                     
                          TWO YEAR ORAL GAVAGE STUDY OF METHYLENE BLUE TRIHYDRATE                                                   
==========================================================================================================                          
WEEK     0 MG/KG                5 MG/KG                  25 MG/KG                 50 MG/KG                                          
         ----------------       ----------------         ----------------         ----------------                                  
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.                               
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)                              
=========================================================================================================                           
  B       110.5       50       109.4     99.0    50     108.9     98.6    50     109.8     99.4    50                               
  1       110.5       50       109.4     99.0    50     108.9     98.6    50     109.8     99.4    50                               
  2       150.1       50       149.7     99.7    50     150.0     99.9    50     150.9    100.5    50                               
  3       181.0       50       181.3    100.2    50     179.4     99.1    50     184.5    101.9    50                               
  4       205.5       50       205.3     99.9    50     204.3     99.4    50     211.7    103.0    50                               
  5       229.6       50       227.4     99.0    50     224.6     97.8    50     232.7    101.4    50                               
  6       248.5       50       245.8     98.9    50     242.7     97.7    50     252.4    101.6    50                               
  7       264.4       50       259.7     98.2    50     258.2     97.7    50     267.0    101.0    50                               
  8       279.6       50       274.1     98.0    50     271.7     97.2    50     280.2    100.2    50                               
  9       292.8       50       287.3     98.1    50     284.2     97.1    50     291.3     99.5    50                               
 10       306.0       50       300.2     98.1    50     296.8     97.0    50     302.8     99.0    50                               
 11       317.2       50       312.3     98.5    50     308.9     97.4    50     313.9     99.0    50                               
 12       328.1       50       324.3     98.8    50     319.5     97.4    50     324.4     98.9    50                               
 13       337.9       50       333.9     98.8    50     327.7     97.0    50     331.8     98.2    50                               
 17       368.3       50       363.4     98.7    50     355.5     96.5    50     353.4     96.0    50                               
 21       390.6       50       386.7     99.0    50     379.0     97.0    50     369.6     94.6    50                               
 25       406.9       50       404.2     99.3    50     390.5     96.0    50     381.3     93.7    50                               
 29       423.8       50       418.4     98.7    50     403.6     95.2    50     396.4     93.5    49                               
 33       441.3       50       431.4     97.8    50     413.2     93.6    50     406.0     92.0    49                               
 37       453.8       50       444.2     97.9    50     424.8     93.6    50     413.6     91.1    49                               
 41       468.0       50       458.6     98.0    50     437.4     93.5    50     421.4     90.0    49                               
 45       476.5       50       468.6     98.3    50     445.8     93.6    50     430.3     90.3    49                               
 49       489.2       50       482.6     98.7    50     460.4     94.1    50     441.4     90.2    49                               
 53       494.8       50       487.3     98.5    50     461.3     93.2    50     445.2     90.0    49                               
 57       502.9       50       495.4     98.5    50     470.6     93.6    50     448.3     89.1    49                               
 61       499.0       50       504.6    101.1    50     470.3     94.2    50     441.7     88.5    48                               
 65       509.2       50       503.3     98.8    50     461.8     90.7    50     444.9     87.4    48                               
 69       514.2       49       504.6     98.1    49     474.3     92.2    50     452.5     88.0    47                               
 73       518.6       49       501.6     96.7    49     472.3     91.1    49     454.2     87.6    45                               
 77       518.5       49       509.5     98.3    49     475.1     91.6    49     453.1     87.4    44                               
 81       520.6       47       511.9     98.3    46     474.8     91.2    49     454.5     87.3    43                               
 85       512.1       45       505.0     98.6    42     478.0     93.3    48     451.9     88.2    42                               
 89       513.8       44       510.1     99.3    42     473.2     92.1    46     453.3     88.2    41                               
 93       506.0       40       502.9     99.4    42     473.3     93.5    45     451.5     89.2    39                               
 97       506.7       36       506.7    100.0    38     470.0     92.8    44     447.6     88.3    36                               
101       499.6       32       497.4     99.6    37     454.7     91.0    42     435.5     87.2    33                               
TERM. SAC.            31                         33                       39                       31                               
==========================================================================================================                          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
                             MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE                                                   
                          TWO YEAR ORAL GAVAGE STUDY OF METHYLENE BLUE TRIHYDRATE                                                   
==========================================================================================================                          
WEEK     0 MG/KG                5 MG/KG                  25 MG/KG                 50 MG/KG                                          
         ----------------       ----------------         ----------------         ----------------                                  
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.                               
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)                              
=========================================================================================================                           
  B        95.6       50        96.2    100.6    50      97.3    101.8    50      96.2    100.6    50                               
  1        95.6       50        96.2    100.6    50      97.3    101.8    50      96.2    100.6    50                               
  2       117.6       50       118.1    100.4    50     120.2    102.2    50     120.0    102.0    50                               
  3       130.7       50       132.1    101.1    50     134.1    102.6    50     135.3    103.5    50                               
  4       140.8       50       143.2    101.7    50     143.2    101.7    50     145.2    103.1    50                               
  5       151.2       50       154.0    101.9    50     153.7    101.7    50     153.8    101.7    50                               
  6       159.6       50       160.6    100.6    50     162.2    101.6    50     163.0    102.1    50                               
  7       166.4       50       166.4    100.0    50     168.9    101.5    50     167.9    100.9    50                               
  8       169.5       50       172.3    101.7    50     174.5    102.9    50     173.7    102.5    50                               
  9       174.1       50       175.2    100.6    50     178.2    102.4    50     177.9    102.2    50                               
 10       177.2       50       180.1    101.6    50     182.3    102.9    50     180.8    102.0    50                               
 11       182.4       50       183.6    100.7    50     186.3    102.1    50     186.2    102.1    50                               
 12       184.1       50       187.0    101.6    50     190.4    103.4    50     188.8    102.6    50                               
 13       187.1       50       189.0    101.0    50     193.9    103.6    50     191.8    102.5    50                               
 17       196.8       50       199.4    101.3    50     202.0    102.6    50     198.7    101.0    50                               
 21       209.1       50       212.3    101.5    49     212.5    101.6    50     207.7     99.3    50                               
 25       211.1       50       215.2    101.9    49     217.1    102.8    50     210.8     99.9    50                               
 29       215.3       50       221.5    102.9    49     222.1    103.2    50     218.4    101.4    50                               
 33       226.4       50       229.0    101.1    49     226.6    100.1    50     222.6     98.3    49                               
 37       234.4       50       236.8    101.0    49     233.7     99.7    50     227.6     97.1    48                               
 41       244.0       50       246.0    100.8    49     240.2     98.4    50     233.6     95.7    47                               
 45       249.7       50       252.3    101.0    49     245.7     98.4    50     237.5     95.1    46                               
 49       257.6       50       259.5    100.7    49     252.8     98.1    50     246.1     95.5    46                               
 53       265.6       49       271.9    102.4    49     259.2     97.6    50     254.0     95.6    45                               
 57       277.9       49       282.4    101.6    48     268.8     96.7    50     261.7     94.2    45                               
 61       287.9       49       292.7    101.7    48     273.0     94.8    50     264.4     91.8    45                               
 65       293.7       49       301.3    102.6    48     281.2     95.7    50     272.9     92.9    45                               
 69       302.6       49       306.7    101.4    48     286.6     94.7    50     279.1     92.2    44                               
 73       309.4       49       314.5    101.6    48     292.3     94.5    49     283.0     91.5    44                               
 77       317.7       48       322.1    101.4    48     293.4     92.4    48     289.0     91.0    42                               
 81       321.4       47       325.3    101.2    48     300.8     93.6    44     292.4     91.0    41                               
 85       328.2       46       328.1    100.0    45     302.5     92.2    43     293.9     89.5    39                               
 89       330.8       46       333.1    100.7    44     303.8     91.8    41     291.3     88.1    39                               
 93       334.6       42       336.3    100.5    40     303.5     90.7    40     295.2     88.2    39                               
 97       335.9       37       340.1    101.3    39     307.2     91.5    39     296.5     88.3    37                               
101       335.9       36       341.7    101.7    33     305.2     90.9    37     294.1     87.6    36                               
TERM. SAC.            35                         32                       36                       35                               
==========================================================================================================                          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.