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TDMS Study 91005-08 Pathology Tables

NTP  EXP/TEST: 91005-08                            METHYLENE BLUE TRIHYDRATE                                      PAGE: 1
TEST TYPE: CHRONIC                              INITIAL AND CURRENT BODY WEIGHT                                   DATE: 04/26/05
ROUTE: GAVAGE                                                                                                     TIME: 09:41:25

                                                         EIS REPORT 03


       FACILITY:  Southern Research Institute

       NTP C#:  91005C

       CONTRACT NUMBER:  N01-ES-05451

       CAS NUMBER:  7220-79-3

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 91005-08                            METHYLENE BLUE TRIHYDRATE                                      PAGE: 2
TEST TYPE: CHRONIC                              INITIAL AND CURRENT BODY WEIGHT                                   DATE: 04/26/05
ROUTE: GAVAGE                                               EISRPT03                                              TIME: 09:41:25
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: B6C3F1-MICE                SEX: FEMALE      WEEK ON DOSE: 106    FIRST DOSE: 07/10/00
----------------------------------------------------------------------------------------------------------------------------------
                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0 MG/KG            50     18.5    0.7        29     57.0    8.8                     29     38.5    8.8

 2.5     MG/KG      50     18.5    0.8        40     62.9    4.8       110.3         40     44.4    4.7

 12.5    MG/KG      50     18.7    0.7        41     61.8    7.4       108.4         41     43.1    7.4

 25      MG/KG      50     18.7    0.8        41     59.0    6.9       103.5         41     40.4    7.0




----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: B6C3F1-MICE                SEX: MALE        WEEK ON DOSE: 106    FIRST DOSE: 07/10/00
----------------------------------------------------------------------------------------------------------------------------------
                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0 MG/KG            50     22.5    0.8        35     52.6    5.7                     35     30.2    5.6

 2.5     MG/KG      50     22.5    0.7        38     51.6    7.1        98.0         38     29.2    7.2

 12.5    MG/KG      50     22.5    0.7        38     50.9    8.0        96.7         38     28.4    8.2

 25      MG/KG      50     22.6    0.8        41     53.8    7.5       102.2         41     31.2    7.4

                                               -----------------------------------
                                               ---------- END-OF-REPORT ----------
                                               -----------------------------------