https://ntp.niehs.nih.gov/go/20977

TDMS Study 91005-08 Pathology Tables

NTP  EXP/TEST: 91005-08                            METHYLENE BLUE TRIHYDRATE                                      PAGE: 1
TEST TYPE: CHRONIC                              INITIAL AND CURRENT BODY WEIGHT                                   DATE: 04/26/05
ROUTE: GAVAGE                                                                                                     TIME: 09:41:25
                                                         EIS REPORT 03
       FACILITY:  Southern Research Institute
       NTP C#:  91005C
       CONTRACT NUMBER:  N01-ES-05451
       CAS NUMBER:  7220-79-3
       ANIMAL SUPPLIER:  TACONIC FARMS
       CAGE RANGE:  ALL
       DATE RANGE: ALL
       REASONS FOR REMOVAL:    ALL
       REMOVAL DATE RANGE:     ALL
       TREATMENT GROUPS:       INCLUDE ALL
NTP  EXP/TEST: 91005-08                            METHYLENE BLUE TRIHYDRATE                                      PAGE: 2
TEST TYPE: CHRONIC                              INITIAL AND CURRENT BODY WEIGHT                                   DATE: 04/26/05
ROUTE: GAVAGE                                               EISRPT03                                              TIME: 09:41:25
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 SPECIES-STRAIN: B6C3F1-MICE                SEX: FEMALE      WEEK ON DOSE: 106    FIRST DOSE: 07/10/00
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                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD
 0 MG/KG            50     18.5    0.7        29     57.0    8.8                     29     38.5    8.8
 2.5     MG/KG      50     18.5    0.8        40     62.9    4.8       110.3         40     44.4    4.7
 12.5    MG/KG      50     18.7    0.7        41     61.8    7.4       108.4         41     43.1    7.4
 25      MG/KG      50     18.7    0.8        41     59.0    6.9       103.5         41     40.4    7.0
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 SPECIES-STRAIN: B6C3F1-MICE                SEX: MALE        WEEK ON DOSE: 106    FIRST DOSE: 07/10/00
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                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD
 0 MG/KG            50     22.5    0.8        35     52.6    5.7                     35     30.2    5.6
 2.5     MG/KG      50     22.5    0.7        38     51.6    7.1        98.0         38     29.2    7.2
 12.5    MG/KG      50     22.5    0.7        38     50.9    8.0        96.7         38     28.4    8.2
 25      MG/KG      50     22.6    0.8        41     53.8    7.5       102.2         41     31.2    7.4
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