TDMS Study 20114-02 Pathology Tables
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: Southern Research Inst SODIUM DICHROMATE DIHYDRATE (VI) DATE: 07/27/04
EXPERIMENT: 20114 TEST: 02 TIME: 09:30:43
PAGE: 1
TEST TYPE: SUBCHRON 90-DAY ROUTE: DOSED WATER NTP: C20114
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: SOUTHERN RESEARCH INSTITUTE SODIUM DICHROMATE DIHYDRATE (VI) DATE: 07/27/04
EXPERIMENT: 20114 TEST: 02 TIME: 9:35:25
TEST TYPE: SUBCHRONIC (90-DAY) ROUTE: DOSED WATER NTP: C20114
CONT: N01-ES-15463 CAS: 7789-12-0
WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE
SUBCHRONIC (90-DAY) DOSED WATER STUDY OF SODIUM DICHROMATE DIHYDRATE (VI)
==================================================================================================================================
0 MG/L 62.5 MG/L 125 MG/L 250 MG/L
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
WATER/ WEIGHT WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
1 4.3 20.4 4.4 21.3 1.02 13 3.0 21.6 0.70 17 3.0 21.1 0.70 36
2 4.2 23.1 4.0 23.4 0.95 11 3.3 23.4 0.79 18 2.9 23.3 0.69 31
3 3.9 25.0 3.4 24.9 0.87 9 3.3 24.9 0.85 17 2.8 24.5 0.72 28
4 3.9 25.7 3.8 24.3 0.97 10 3.2 25.1 0.82 16 2.7 25.0 0.69 27
5 4.0 27.1 4.2 25.9 1.05 10 3.3 26.5 0.83 16 2.8 25.9 0.70 27
6 3.7 28.9 3.7 27.3 1.00 9 3.4 27.4 0.92 16 2.7 27.0 0.73 25
7 4.0 30.2 4.2 28.2 1.05 9 3.6 28.2 0.90 16 2.8 27.8 0.70 25
8 4.1 32.2 3.9 30.1 0.95 8 3.7 30.0 0.90 15 3.2 28.9 0.78 27
9 3.8 33.1 4.5 30.6 1.18 9 3.6 30.4 0.95 15 2.9 29.5 0.76 25
10 3.5 34.7 4.0 32.2 1.14 8 3.5 32.2 1.00 14 3.0 30.8 0.86 24
11 3.2 35.6 3.8 33.7 1.19 7 3.3 33.3 1.03 12 2.7 31.0 0.84 22
12 3.8 36.1 3.6 34.5 0.95 7 3.3 33.8 0.87 12 2.5 31.9 0.66 19
13 3.8 37.9 4.5 35.6 1.18 8 4.2 34.2 1.11 15 3.3 32.6 0.87 25
1 TO 13 WEEKS
----------------
MEAN 3.9 30.0 4.0 28.6 1.04 9 3.4 28.5 0.90 15 2.9 27.6 0.75 26
SD(D) 0.3 0.3 0.11 2 0.3 0.11 2 0.2 0.07 4
CV(E) 7.4 8.2 10.1 18.2 8.6 12.1 10.7 7.9 9.5 15.4
==================================================================================================================================
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE
SUBCHRONIC (90-DAY) DOSED WATER STUDY OF SODIUM DICHROMATE DIHYDRATE (VI)
=============================================================================
500 MG/L 1000 MG/L
--------------------------------- ---------------------------------
DOSE/ DOSE/
GRAMS BODY CONTROL GRAMS BODY CONTROL
WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/
WEEK DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
=============================================================================
1 2.3 20.7 0.53 55 2.4 21.4 0.56 114
2 2.3 22.3 0.55 52 2.1 22.4 0.50 93
3 2.1 23.6 0.54 44 1.8 23.4 0.46 75
4 2.2 24.0 0.56 46 2.1 23.8 0.54 87
5 2.2 25.1 0.55 44 2.1 25.4 0.53 82
6 2.4 25.8 0.65 47 2.4 25.9 0.65 94
7 2.4 26.3 0.60 46 2.2 26.8 0.55 84
8 2.6 27.9 0.63 47 2.9 28.1 0.71 103
9 2.6 28.2 0.68 46 2.3 28.2 0.61 80
10 2.1 29.3 0.60 36 2.4 29.1 0.69 83
11 2.1 29.4 0.66 36 1.8 29.2 0.56 63
12 2.2 29.6 0.58 37 2.0 29.6 0.53 67
13 3.2 30.5 0.84 52 2.8 30.5 0.74 91
1 TO 13 WEEKS
----------------
MEAN 2.4 26.4 0.61 45 2.3 26.4 0.59 86
SD(D) 0.3 0.08 6 0.3 0.09 14
CV(E) 12.4 13.7 13.1 14.8 14.5 16.0
=============================================================================
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
SUBCHRONIC (90-DAY) DOSED WATER STUDY OF SODIUM DICHROMATE DIHYDRATE (VI)
==================================================================================================================================
0 MG/L 62.5 MG/L 125 MG/L 250 MG/L
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
WATER/ WEIGHT WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
1 3.0 17.9 3.1 18.7 1.03 10 2.0 18.7 0.67 13 2.1 18.3 0.70 28
2 3.2 19.9 3.3 19.7 1.03 10 2.5 19.5 0.78 16 2.3 19.8 0.72 29
3 3.8 21.2 3.2 21.2 0.84 10 2.4 21.2 0.63 14 2.2 21.1 0.58 26
4 3.3 21.3 4.1 21.8 1.24 12 2.8 21.0 0.85 17 3.0 21.9 0.91 34
5 3.0 22.7 3.0 22.3 1.00 8 2.7 22.2 0.90 15 2.4 22.6 0.80 26
6 2.9 23.3 3.0 22.8 1.03 8 2.6 23.0 0.90 14 3.3 23.5 1.14 35
7 3.9 21.5 3.4 24.1 0.87 9 2.8 23.1 0.72 15 2.7 22.3 0.69 30
8 3.2 24.4 4.6 24.4 1.44 12 2.8 23.4 0.88 15 2.4 24.1 0.75 25
9 2.9 25.0 3.3 25.2 1.14 8 3.0 25.1 1.03 15 2.2 24.8 0.76 23
10 3.4 25.7 3.4 25.3 1.00 8 2.9 24.8 0.85 15 3.1 25.0 0.91 31
11 3.4 26.7 3.1 26.4 0.91 7 2.8 25.0 0.82 14 2.3 25.4 0.68 23
12 3.1 28.2 3.7 26.5 1.19 9 2.6 25.7 0.84 13 2.2 24.6 0.71 22
13 3.3 27.7 2.9 28.0 0.88 6 2.6 25.5 0.79 13 2.4 25.5 0.73 23
1 TO 13 WEEKS
----------------
MEAN 3.3 23.5 3.4 23.6 1.05 9 2.7 22.9 0.82 15 2.5 23.0 0.77 27
SD(D) 0.3 0.5 0.17 2 0.3 0.11 1 0.4 0.14 4
CV(E) 9.4 14.7 16.2 17.8 9.9 13.0 7.7 15.7 18.3 15.9
==================================================================================================================================
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
SUBCHRONIC (90-DAY) DOSED WATER STUDY OF SODIUM DICHROMATE DIHYDRATE (VI)
=============================================================================
500 MG/L 1000 MG/L
--------------------------------- ---------------------------------
DOSE/ DOSE/
GRAMS BODY CONTROL GRAMS BODY CONTROL
WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/
WEEK DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
=============================================================================
1 1.5 18.1 0.50 43 1.1 18.8 0.37 56
2 1.8 18.7 0.56 47 1.5 18.2 0.47 83
3 1.8 20.9 0.47 42 1.8 19.7 0.47 90
4 1.8 20.2 0.55 45 1.6 20.2 0.48 81
5 1.9 21.4 0.63 44 1.5 20.4 0.50 74
6 2.7 22.4 0.93 60 1.8 21.8 0.62 81
7 1.8 22.3 0.46 41 1.8 21.9 0.46 81
8 1.9 22.6 0.59 43 1.7 22.7 0.53 76
9 2.1 23.6 0.72 45 1.8 22.7 0.62 79
10 2.0 24.1 0.59 41 1.6 23.7 0.47 68
11 2.2 24.2 0.65 45 1.8 23.2 0.53 76
12 1.9 24.4 0.61 39 1.5 23.7 0.48 65
13 2.0 24.8 0.61 40 1.5 24.1 0.45 62
1 TO 13 WEEKS
----------------
MEAN 2.0 22.1 0.61 44 1.6 21.6 0.50 75
SD(D) 0.3 0.12 5 0.2 0.07 10
CV(E) 14.1 20.1 11.9 12.7 13.6 12.8
=============================================================================
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
DIAGNOSTIC TRAILER REPORT
WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE
SUBCHRONIC (90-DAY) DOSED WATER STUDY OF SODIUM DICHROMATE DIHYDRATE (VI)
==================================================================================================================================
0 MG/L 62.5 MG/L 125 MG/L 250 MG/L 500 MG/L
---------------------- ---------------------- ---------------------- ---------------------- ----------------------
DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM
WEEK WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS
===================================================================================================================================
B 20.4 10 21.3 10 21.6 10 21.1 10 20.7 10
1 4.3 1306 20.4 10 4.4 1332 21.3 10 3.0 1382 21.6 10 3.0 1122 21.1 10 2.3 1021 20.7 10
2 4.2 1484 23.1 10 4.0 1506 23.4 10 3.3 1599 23.4 10 2.9 1650 23.3 10 2.3 1460 22.3 10
3 3.9 1623 25.0 10 3.4 1623 24.9 10 3.3 1503 24.9 10 2.8 1594 24.5 10 2.1 1620 23.6 10
4 3.9 1505 25.7 10 3.8 1560 24.3 10 3.2 1643 25.1 10 2.7 1572 25.0 10 2.2 1407 24.0 10
5 4.0 1530 27.1 10 4.2 1614 25.9 10 3.3 1470 26.5 10 2.8 1564 25.9 10 2.2 1660 25.1 10
6 3.7 1559 28.9 10 3.7 1538 27.3 10 3.4 1599 27.4 10 2.7 1652 27.0 10 2.4 1559 25.8 10
7 4.0 1557 30.2 10 4.2 1629 28.2 10 3.6 1535 28.2 10 2.8 1680 27.8 10 2.4 1680 26.3 10
8 4.1 1435 32.2 10 3.9 1560 30.1 10 3.7 1610 30.0 10 3.2 1587 28.9 10 2.6 1654 27.9 10
9 3.8 1606 33.1 10 4.5 1337 30.6 10 3.6 1437 30.4 10 2.9 1642 29.5 10 2.6 1524 28.2 10
10 3.5 1649 34.7 10 4.0 1603 32.2 10 3.5 1413 32.2 10 3.0 1632 30.8 10 2.1 1519 29.3 10
11 3.2 1443 35.6 10 3.8 1593 33.7 10 3.3 1466 33.3 10 2.7 1341 31.0 10 2.1 1556 29.4 10
12 3.8 1616 36.1 10 3.6 1700 34.5 10 3.3 1545 33.8 10 2.5 1673 31.9 10 2.2 1629 29.6 10
13 3.8 635 37.9 10 4.5 660 35.6 10 4.2 635 34.2 10 3.3 660 32.6 10 3.2 660 30.5 10
MEAN BODY WGT FOR WEEKS
1 TO 13 30.0 28.6 28.5 27.6 26.4
==================================================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
DIAGNOSTIC TRAILER REPORT
WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE
SUBCHRONIC (90-DAY) DOSED WATER STUDY OF SODIUM DICHROMATE DIHYDRATE (VI)
==============================
1000 MG/L
----------------------
DAILY WATER BODY NUM
WEEK WATER HOURS WGT WGTS
===============================
B 21.4 10
1 2.4 1278 21.4 10
2 2.1 1600 22.4 10
3 1.8 1645 23.4 10
4 2.1 1501 23.8 10
5 2.1 1616 25.4 10
6 2.4 1587 25.9 10
7 2.2 1558 26.8 10
8 2.9 1535 28.1 10
9 2.3 1646 28.2 10
10 2.4 1559 29.1 10
11 1.8 1580 29.2 10
12 2.0 1644 29.6 10
13 2.8 660 30.5 10
MEAN BODY WGT FOR WEEKS
1 TO 13 26.4
==============================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
DIAGNOSTIC TRAILER REPORT
WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
SUBCHRONIC (90-DAY) DOSED WATER STUDY OF SODIUM DICHROMATE DIHYDRATE (VI)
==================================================================================================================================
0 MG/L 62.5 MG/L 125 MG/L 250 MG/L 500 MG/L
---------------------- ---------------------- ---------------------- ---------------------- ----------------------
DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM
WEEK WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS
===================================================================================================================================
B 17.9 10 18.7 10 18.7 10 18.3 10 18.1 10
1 3.0 1070 17.9 10 3.1 1198 18.7 10 2.0 1194 18.7 10 2.1 1090 18.3 10 1.5 1202 18.1 10
2 3.2 1650 19.9 10 3.3 1650 19.7 10 2.5 1650 19.5 10 2.3 1525 19.8 10 1.8 1648 18.7 10
3 3.8 1457 21.2 10 3.2 1712 21.2 10 2.4 1714 21.2 10 2.2 1590 21.1 10 1.8 1714 20.9 10
4 3.3 1277 21.3 10 4.1 1414 21.8 10 2.8 1654 21.0 10 3.0 1654 21.9 10 1.8 1297 20.2 10
5 3.0 1676 22.7 10 3.0 1676 22.3 10 2.7 1676 22.2 10 2.4 1560 22.6 10 1.9 1677 21.4 10
6 2.9 1435 23.3 10 3.0 1309 22.8 10 2.6 1680 23.0 10 3.3 1175 23.5 10 2.7 1556 22.4 10
7 3.9 1680 21.5 10 3.4 1543 24.1 10 2.8 1676 23.1 10 2.7 1549 22.3 10 1.8 1547 22.3 10
8 3.2 1712 24.4 10 4.6 1712 24.4 10 2.8 1572 23.4 10 2.4 1714 24.1 10 1.9 1588 22.6 10
9 2.9 1652 25.0 10 3.3 1531 25.2 10 3.0 1531 25.1 10 2.2 1388 24.8 10 2.1 1531 23.6 10
10 3.4 1678 25.7 10 3.4 1680 25.3 10 2.9 1682 24.8 10 3.1 1577 25.0 10 2.0 1684 24.1 10
11 3.4 1682 26.7 10 3.1 1680 26.4 10 2.8 1678 25.0 10 2.3 1678 25.4 10 2.2 1676 24.2 10
12 3.1 1684 28.2 10 3.7 1684 26.5 10 2.6 1684 25.7 10 2.2 1684 24.6 10 1.9 1684 24.4 10
13 3.3 682 27.7 10 2.9 682 28.0 10 2.6 682 25.5 10 2.4 682 25.5 10 2.0 682 24.8 10
MEAN BODY WGT FOR WEEKS
1 TO 13 23.5 23.6 22.9 23.0 22.1
==================================================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
DIAGNOSTIC TRAILER REPORT
WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
SUBCHRONIC (90-DAY) DOSED WATER STUDY OF SODIUM DICHROMATE DIHYDRATE (VI)
==============================
1000 MG/L
----------------------
DAILY WATER BODY NUM
WEEK WATER HOURS WGT WGTS
===============================
B 18.8 10
1 1.1 1202 18.8 10
2 1.5 1186 18.2 10
3 1.8 1714 19.7 10
4 1.6 1525 20.2 10
5 1.5 1678 20.4 10
6 1.8 1682 21.8 10
7 1.8 1553 21.9 10
8 1.7 1325 22.7 10
9 1.8 1531 22.7 10
10 1.6 1686 23.7 10
11 1.8 1674 23.2 10
12 1.5 1684 23.7 10
13 1.5 682 24.1 10
MEAN BODY WGT FOR WEEKS
1 TO 13 21.6
==============================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.