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TDMS Study 96006-06 Pathology Tables

NTP Experiment-Test: 96006-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: SUBCHRON 90-DAY                          WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/11/02
Route: GAVAGE                                 DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC)                   Time: 14:10:00

                                                         Final #1/Mice




       Facility:  BIORELIANCE

       Chemical CAS #:  5407-04-5

       Lock Date:  07/20/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

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NTP Experiment-Test: 96006-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 90-DAY                          WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/11/02    
Route: GAVAGE                                 DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC)                   Time: 14:10:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           VEHICLE      6.25         12.5         25 MG/KG     50 MG/KG     100          
                                                      CONTROL      MG/KG        MG/KG                                  MG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Natural Death                                                                                                       2           
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10            7           
    Natural Death                                                                                                       1           
                                                                                                                                    
  Animals Examined Microscopically                    10            1            1                                     10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Salivary Glands                                    (10)                                                             (8)          
      Infiltration Cellular, Focal, Lymphocyte         1 [1.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)                                                             (7)          
      Subcapsular, Hyperplasia, Focal                 10 [1.0]                                                          7 [1.0]     
   Thyroid Gland                                      (10)                                                             (8)          
      Ectopic Thymus                                   2 [1.0]                                                          1 [1.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Uterus                                             (10)                                                             (8)          
      Endometrium, Hyperplasia, Cystic                 1 [1.0]                                                          1 [1.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
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NTP Experiment-Test: 96006-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 90-DAY                          WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/11/02    
Route: GAVAGE                                 DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC)                   Time: 14:10:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           VEHICLE      6.25         12.5         25 MG/KG     50 MG/KG     100          
                                                      CONTROL      MG/KG        MG/KG                                  MG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Spleen                                             (10)                                                             (7)          
      Hematopoietic Cell Proliferation                 3 [1.0]                                                          1 [1.0]     
   Thymus                                             (10)                                                             (7)          
      Atrophy                                                                                                           1 [1.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)                                                             (8)          
      Hydronephrosis                                   1 [4.0]                                                                      
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96006-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 90-DAY                          WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/11/02    
Route: GAVAGE                                 DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC)                   Time: 14:10:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             VEHICLE      6.25         12.5         25 MG/KG     50 MG/KG     100          
                                                      CONTROL      MG/KG        MG/KG                                  MG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10           10           
                                                                                                                                    
  Animals Examined Microscopically                    10                                                               10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Stomach, Forestomach                               (10)                                                             (10)         
      Epithelium, Hyperplasia, Diffuse                                                                                  1 [1.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)                                                             (10)         
      Subcapsular, Hyperplasia, Focal                  1 [1.0]                                                          1 [1.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (10)                                                             (10)         
      Hematopoietic Cell Proliferation                                                                                  1 [1.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96006-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 90-DAY                          WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/11/02    
Route: GAVAGE                                 DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC)                   Time: 14:10:00    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             VEHICLE      6.25         12.5         25 MG/KG     50 MG/KG     100          
                                                      CONTROL      MG/KG        MG/KG                                  MG/KG        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)                                                             (10)         
      Renal Tubule, Vacuolization Cytoplasmic,                                                                                      
           Focal                                       9 [2.0]                                                          8 [1.9]     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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