TDMS Study 96006-06 Pathology Tables
NTP Experiment-Test: 96006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 03/11/02 Route: GAVAGE DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Time: 14:10:00 Final #1/Mice Facility: BIORELIANCE Chemical CAS #: 5407-04-5 Lock Date: 07/20/01 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 1 NTP Experiment-Test: 96006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 03/11/02 Route: GAVAGE DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Time: 14:10:00 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE 6.25 12.5 25 MG/KG 50 MG/KG 100 CONTROL MG/KG MG/KG MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 10 10 10 10 10 Early Deaths Natural Death 2 Survivors Terminal Sacrifice 10 10 10 10 10 7 Natural Death 1 Animals Examined Microscopically 10 1 1 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Salivary Glands (10) (8) Infiltration Cellular, Focal, Lymphocyte 1 [1.0] ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (10) (7) Subcapsular, Hyperplasia, Focal 10 [1.0] 7 [1.0] Thyroid Gland (10) (8) Ectopic Thymus 2 [1.0] 1 [1.0] ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Uterus (10) (8) Endometrium, Hyperplasia, Cystic 1 [1.0] 1 [1.0] ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 2 NTP Experiment-Test: 96006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 03/11/02 Route: GAVAGE DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Time: 14:10:00 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE 6.25 12.5 25 MG/KG 50 MG/KG 100 CONTROL MG/KG MG/KG MG/KG ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Spleen (10) (7) Hematopoietic Cell Proliferation 3 [1.0] 1 [1.0] Thymus (10) (7) Atrophy 1 [1.0] ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM None ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (8) Hydronephrosis 1 [4.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 3 NTP Experiment-Test: 96006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 03/11/02 Route: GAVAGE DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Time: 14:10:00 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE 6.25 12.5 25 MG/KG 50 MG/KG 100 CONTROL MG/KG MG/KG MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 10 10 10 10 10 Early Deaths Survivors Terminal Sacrifice 10 10 10 10 10 10 Animals Examined Microscopically 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Stomach, Forestomach (10) (10) Epithelium, Hyperplasia, Diffuse 1 [1.0] ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (10) (10) Subcapsular, Hyperplasia, Focal 1 [1.0] 1 [1.0] ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM None ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Spleen (10) (10) Hematopoietic Cell Proliferation 1 [1.0] ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 4 NTP Experiment-Test: 96006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 03/11/02 Route: GAVAGE DIMETHYLAMINOPROPYLCHLORIDE, HYDROCHLORIDE (DMPC) Time: 14:10:00 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE 6.25 12.5 25 MG/KG 50 MG/KG 100 CONTROL MG/KG MG/KG MG/KG ____________________________________________________________________________________________________________________________________ None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM None ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) Renal Tubule, Vacuolization Cytoplasmic, Focal 9 [2.0] 8 [1.9] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 5 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------