National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/27983

TDMS Study 93022-03 Pathology Tables

NTP Experiment-Test: 93022-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                   2,4-DECADIENAL                                      Date: 09/08/99
Route: GAVAGE                                                                                                     Time: 13:48:41

                                                       13 WEEK SUBCHRONIC




       Facility:  Southern Research Institute

       Chemical CAS #:  25152-84-5

       Lock Date:  07/30/97

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 93022-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                   2,4-DECADIENAL                                      Date: 09/08/99  
Route: GAVAGE                                                                                                     Time: 13:48:41  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0            50           100          200          400          800             
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY        
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10           10           

  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)                                                             (10)         
      Hepatodiaphragmatic Nodule                       4 (40%)                                                                      
      Infiltration Cellular, Mixed Cell                1 (10%)                                                                      
   Mesentery                                          (1)                                    (1)                                    
      Fat, Necrosis                                    1 (100%)                               1 (100%)                              
   Stomach, Forestomach                               (10)         (10)         (9)          (10)         (10)         (10)         
      Edema                                                                                                1 (10%)      1 (10%)     
      Inflammation, Chronic Active                                  1 (10%)                                2 (20%)      9 (90%)     
      Epithelium, Degeneration                                                                             2 (20%)     10 (100%)    
      Epithelium, Hyperplasia                                                                              6 (60%)     10 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)                                                             (10)         
      Accessory Adrenal Cortical Nodule                                                                                 1 (10%)     
   Pituitary Gland                                    (10)                                                             (10)         
      Pars Distalis, Cyst                              1 (10%)                                                                      
   Thyroid Gland                                      (10)                                                             (10)         
      Ultimobranchial Cyst                                                                                              1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 93022-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                   2,4-DECADIENAL                                      Date: 09/08/99  
Route: GAVAGE                                                                                                     Time: 13:48:41  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0            50           100          200          400          800             
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)                                   (1)          (1)          (10)         
      Cyst                                             1 (10%)                                1 (100%)     1 (100%)                 
   Uterus                                             (10)                                   (3)                       (10)         
      Hydrometra                                       4 (40%)                                3 (100%)                  2 (20%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (9)                                                              (9)          
      Hemorrhage                                       2 (22%)                                                          1 (11%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Nose                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Exudate                                                                                              1 (10%)      1 (10%)     
      Olfactory Epithelium, Atrophy                                                                                     1 (10%)     
      Olfactory Epithelium, Necrosis                                                          1 (10%)                               
      Respiratory Epithelium, Inflammation                                       1 (10%)                                            
      Respiratory Epithelium, Metaplasia, Squamous                                                         1 (10%)                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 93022-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                   2,4-DECADIENAL                                      Date: 09/08/99  
Route: GAVAGE                                                                                                     Time: 13:48:41  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0            50           100          200          400          800             
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 93022-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                   2,4-DECADIENAL                                      Date: 09/08/99  
Route: GAVAGE                                                                                                     Time: 13:48:41  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0            50           100          200          400          800             
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY        
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10           10           

  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (10)                                                             (10)         
      Erosion, Focal                                                                                                    1 (10%)     
      Inflammation, Chronic Active                                                                                      1 (10%)     
   Liver                                              (10)                                                             (10)         
      Hepatodiaphragmatic Nodule                       1 (10%)                                                                      
      Infiltration Cellular, Mixed Cell                1 (10%)                                                          1 (10%)     
   Stomach, Forestomach                               (10)         (10)         (10)         (10)         (10)         (10)         
      Edema                                                                                                2 (20%)                  
      Inflammation, Chronic Active                                                                         2 (20%)      2 (20%)     
      Epithelium, Degeneration                                                                             1 (10%)      5 (50%)     
      Epithelium, Hyperplasia                                                                              4 (40%)      6 (60%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)                                                             (10)         
      Cardiomyopathy                                   3 (30%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)                                                             (10)         
      Accessory Adrenal Cortical Nodule                1 (10%)                                                                      
   Pituitary Gland                                    (10)                                                             (10)         
      Pars Distalis, Cyst                              1 (10%)                                                                      
   Thyroid Gland                                      (10)                                                             (10)         
      Ultimobranchial Cyst                                                                                              1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 93022-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                   2,4-DECADIENAL                                      Date: 09/08/99  
Route: GAVAGE                                                                                                     Time: 13:48:41  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0            50           100          200          400          800             
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (10)                                                             (10)         
      Hemorrhage                                       7 (70%)                                                          4 (40%)     
   Lymph Node, Mesenteric                             (10)                                                             (10)         
      Hemorrhage                                       1 (10%)                                                                      
   Thymus                                             (10)                                                (1)          (9)          
      Hemorrhage                                                                                           1 (100%)     2 (22%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (10)                                                (1)          (10)         
      Inflammation, Chronic                                                                                1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)                                                             (10)         
      Hemorrhage                                       4 (40%)                                                          3 (30%)     
      Infiltration Cellular, Histiocyte                1 (10%)                                                                      
      Metaplasia, Osseous                                                                                               1 (10%)     
   Nose                                               (10)         (10)         (10)         (9)          (10)         (10)         
      Exudate                                                                                              2 (20%)      6 (60%)     
      Inflammation, Chronic                            1 (10%)                                                          1 (10%)     
      Olfactory Epithelium, Atrophy                                                           1 (11%)      1 (10%)      4 (40%)     
      Olfactory Epithelium, Necrosis                                                          1 (11%)                               
      Respiratory Epithelium, Hyperplasia                                                                               1 (10%)     
      Sinus, Exudate                                                                          1 (11%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 93022-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                   2,4-DECADIENAL                                      Date: 09/08/99  
Route: GAVAGE                                                                                                     Time: 13:48:41  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0            50           100          200          400          800             
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Turbinate, Osteofibrosis                                                                1 (11%)      1 (10%)      3 (30%)     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             
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