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P17 - Neoplasms by Individual Animal (systemic lesions abridged) (Rats)

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03

Route: GAVAGE                                                                                                     Time: 09:16:57



                                                           FINAL/RATS









       Facility:  Battelle Columbus Laboratory



       Chemical CAS #:  140-67-0



       Lock Date:  09/03/02



       Cage Range:  All



       Reasons For Removal:    All



       Removal Date Range:     All



       Treatment Groups:       Include All






Note:  Animals arranged according to days on test



                                                              Page   1





NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |

    0 MG/KG                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |     L      |

                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

                                           |__________________________________________________________________________|____________|

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page   2                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |

    0 MG/KG                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |     L      |

                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ENDOCRINE SYSTEM - cont                   |                                                                          |            |

                                           |                                                                          |            |

   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M                                             |            |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page   3                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |

    0 MG/KG                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |     L      |

                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |

                                           |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Eye                                     | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page   4                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |

    0 MG/KG                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |     L      |

                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 URINARY SYSTEM - cont                     |                                                                          |            |

                                           |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|

   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page   5                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |

    37.5                                   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     L      |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page   6                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |

    37.5                                   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     L      |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 RESPIRATORY SYSTEM - cont                 |                                                                          |            |

                                           |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|

   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page   7                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |

    75                                     | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                            |     L      |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page   8                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |

    75                                     | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                            |     L      |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 RESPIRATORY SYSTEM - cont                 |                                                                          |            |

                                           |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|

   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page   9                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |     A      |

    150                                    | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |     L      |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Mesentery                               | +                                                                        |   1        |

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  10                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |     A      |

    150                                    | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |     L      |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 NERVOUS SYSTEM - cont                     |                                                                          |            |

                                           |                                                                          |            |

   Brain                                   |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|

   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  11                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |

    300                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |     L      |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  12                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |

    300                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |     L      |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 RESPIRATORY SYSTEM - cont                 |                                                                          |            |

                                           |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|

   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  13                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |

    600                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

                                           |__________________________________________________________________________|____________|

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  14                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |

    600                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ENDOCRINE SYSTEM - cont                   |                                                                          |            |

                                           |                                                                          |            |

   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Lymph Node                              |       +           +     +  +                                             |   4        |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M                                             |            |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  15                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |

    600                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |

                                           |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Eye                                     | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  16                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |

    600                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|

   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  17                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |

    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |     L      |

                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

                                           |__________________________________________________________________________|____________|

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  18                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |

    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |     L      |

                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ENDOCRINE SYSTEM - cont                   |                                                                          |            |

                                           |                                                                          |            |

   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M                                             |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  19                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |

    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |     L      |

                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |

                                           |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Eye                                     | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  20                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |

    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |     L      |

                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |

                                           |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|

   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  21                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |

    37.5                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                             Page  22                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |

    37.5                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 NERVOUS SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Hamartoma                            |                            X                                             |          1 |

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|

   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  23                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |

    75                                     | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |     L      |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                             Page  24                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |

    75                                     | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |     L      |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 NERVOUS SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|

   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  25                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |

    150                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |     L      |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Mesentery                               | +                                                                        |   1        |

                                           |__________________________________________________________________________|____________|

   Oral Mucosa                             |    +                                                                     |   1        |

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  26                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |

    150                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |     L      |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|

   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  27                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |

    300                                    | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |     L      |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Lymph Node                              |    +  +     +                                                            |   3        |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +        +     +  +  +  +  +                                             |   7        |

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  28                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |

    300                                    | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |     L      |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|

   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  29                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |

    600                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     L      |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Cholangiocarcinoma, Multiple         |             X  X                                                         |          2 |

      Hepatocellular Adenoma               | X                                                                        |          1 |

                                           |__________________________________________________________________________|____________|

   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  30                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |

    600                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     L      |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ENDOCRINE SYSTEM                          |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Preputial Gland                         | +  +  +  +  +  M  +  +  +  +                                             |   9        |

                                           |__________________________________________________________________________|____________|

   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Lymph Node                              | +     +                 +                                                |   3        |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  31                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |

    600                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     L      |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |

                                           |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M                                             |            |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  32                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:16:57    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |

    600                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     L      |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |

                                           |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Eye                                     | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|

   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    


                                                                                                                                    

                                                             Page  33                                                               

                                                                                                                                   

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                                  ----------              END OF REPORT             ----------                                      

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