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E03 - Initial and Current Body Weight (Mice)

NTP  EXP/TEST: 60946-02                                    ESTRAGOLE                                              PAGE: 1

TEST TYPE: SUBCHRON 90-DAY                      INITIAL AND CURRENT BODY WEIGHT                                   DATE: 10/08/03

ROUTE: GAVAGE                                                                                                     TIME: 07:55:03



                                                         EIS REPORT 03

                                                           FINAL/MICE





       FACILITY:  Battelle Columbus Laboratory



       NTP C#:  C60946



       CONTRACT NUMBER:  NO1-ES-15460



       CAS NUMBER:  140-67-0



       ANIMAL SUPPLIER:  TACONIC FARMS



       CAGE RANGE:  ALL



       DATE RANGE: ALL



       REASONS FOR REMOVAL:    ALL



       REMOVAL DATE RANGE:     ALL



       TREATMENT GROUPS:       INCLUDE ALL



NTP  EXP/TEST: 60946-02                                    ESTRAGOLE                                              PAGE: 2

TEST TYPE: SUBCHRON 90-DAY                      INITIAL AND CURRENT BODY WEIGHT                                   DATE: 10/08/03

ROUTE: GAVAGE                                               EISRPT03                                              TIME: 07:55:03

----------------------------------------------------------------------------------------------------------------------------------

 SPECIES-STRAIN: B6C3F1-MICE                SEX: FEMALE      WEEK ON DOSE: 14     FIRST DOSE: 09/12/01

----------------------------------------------------------------------------------------------------------------------------------

                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------

TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD



 0 MG/KG            10     18.3    0.6        10     29.8    2.0                     10     11.5    1.6



 37.5    MG/KG      10     18.1    0.8        10     28.7    2.4        96.3         10     10.7    2.3



 75      MG/KG      10     18.0    0.8        10     26.6    2.2        89.2         10      8.6    1.8



 150     MG/KG      10     18.2    0.6        10     25.7    0.9        86.2         10      7.5    0.9



 300     MG/KG      10     18.2    0.6        10     24.3    1.1        81.5         10      6.1    1.2



 600     MG/KG      10     18.5    0.6         0      0.0    0.0                      0      0.0    0.0









----------------------------------------------------------------------------------------------------------------------------------

 SPECIES-STRAIN: B6C3F1-MICE                SEX: MALE        WEEK ON DOSE: 14     FIRST DOSE: 09/13/01

----------------------------------------------------------------------------------------------------------------------------------

                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------

TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD



 0 MG/KG            10     22.2    1.0        10     36.1    3.2                     10     13.8    2.6



 37.5    MG/KG      10     22.5    0.8        10     36.3    3.0       100.5         10     13.9    2.6



 75      MG/KG      10     22.2    0.9        10     37.2    4.1       103.0         10     15.0    3.6



 150     MG/KG      10     22.5    0.8        10     34.5    1.6        95.5         10     12.0    1.3



 300     MG/KG      10     22.5    1.2        10     30.6    2.6        84.7         10      8.1    1.7



 600     MG/KG      10     22.4    1.2         9     28.4    1.4        78.6          9      6.0    1.4



                                               -----------------------------------

                                               ---------- END-OF-REPORT ----------

                                               -----------------------------------