National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/41006

P09 - Non-Neoplastic Lesions by Individual Animal (Mice)

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03

Route: GAVAGE                                                                                                     Time: 08:01:36



                                                           FINAL/MICE









       Facility:  Battelle Columbus Laboratory



       Chemical CAS #:  140-67-0



       Lock Date:  05/28/02



       Cage Range:  All



       Reasons For Removal:    All



       Removal Date Range:     All



       Treatment Groups:       Include All









































































                                                              Page   1





NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    0 MG/KG                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |

                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Inflammation, Chronic Active         | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

      Pigmentation, Hemosiderin            |                   1                                                      |      1  1.0|

                                           |__________________________________________________________________________|____________|

   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page   2                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    0 MG/KG                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |

                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ENDOCRINE SYSTEM                          |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Subcapsular, Hyperplasia             | 2  2  2  2  2  1  1  2  1  2                                             |     10  1.7|

                                           |__________________________________________________________________________|____________|

   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Parathyroid Gland                       | +  +  +  +  M  M  +  M  +  +                                             |   7        |

      Cyst                                 |                   1                                                      |      1  1.0|

                                           |__________________________________________________________________________|____________|

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M                                             |   9        |

                                           |__________________________________________________________________________|____________|

   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Endometrium, Hyperplasia, Cystic     |    1                                                                     |      1  1.0|

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page   3                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    0 MG/KG                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |

                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Hematopoietic Cell Proliferation     | 1  1  1  1  1  1  2  1  1  1                                             |     10  1.1|

                                           |__________________________________________________________________________|____________|

   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Eye                                     | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                                                                                                    

                                                             Page   4                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    0 MG/KG                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |

                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Nephropathy                          |    1  1           1     1  1                                             |      5  1.0|

                                           |__________________________________________________________________________|____________|

   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page   5                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    37.5                                   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Inflammation, Chronic Active         | 1  1  1     1  1  2  1  1  1                                             |      9  1.1|

      Hepatocyte, Degeneration             |       1                                                                  |      1  1.0|

      Oval Cell, Hyperplasia               |          1                                                               |      1  1.0|

                                           |__________________________________________________________________________|____________|

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M                                             |   9        |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Hematopoietic Cell Proliferation     | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page   6                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    37.5                                   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 NERVOUS SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +     +  +  +                                             |   9        |

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page   7                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    75                                     | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Inflammation, Chronic Active         | 1  1  1  1  1  1  2  1  1  1                                             |     10  1.1|

      Hepatocyte, Degeneration             |       1        1           1                                             |      3  1.0|

      Hepatocyte, Hypertrophy              |       1  1     1                                                         |      3  1.0|

      Oval Cell, Hyperplasia               | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

                                           |__________________________________________________________________________|____________|

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +                                             |   9        |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Hematopoietic Cell Proliferation     | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page   8                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    75                                     | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +     +  +  +  +  +  +                                             |   9        |

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page   9                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      A     |

    150                                    | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Inflammation, Chronic Active         | 2  1  1  1  1  2  1  2  2  1                                             |     10  1.4|

      Mixed Cell Focus                     |                      X                                                   |      1     |

      Bile Duct, Hyperplasia               |       1                                                                  |      1  1.0|

      Hepatocyte, Degeneration             | 1  2  1  1  1  2  2  2  1  2                                             |     10  1.5|

      Hepatocyte, Hypertrophy              | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|

      Oval Cell, Hyperplasia               | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|

                                           |__________________________________________________________________________|____________|

   Stomach, Forestomach                    | +  +  +  +  +  +  +     +  +                                             |   9        |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Mineralization                       |          1                                                               |      1  1.0|

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Clitoral Gland                          |                +                                                         |   1        |

      Pigmentation, Melanin                |                2                                                         |      1  2.0|

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  10                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      A     |

    150                                    | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |

   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Hematopoietic Cell Proliferation     | 1  1  1  1  1  1  1  1  1  2                                             |     10  1.1|

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Olfactory Epithelium, Degeneration   |                1  1                                                      |      2  1.0|

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  11                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |

    300                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Muscularis, Degeneration             | 1                                                                        |      1  1.0|

                                           |__________________________________________________________________________|____________|

   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Goblet Cell, Hyperplasia             |                      1                                                   |      1  1.0|

                                           |__________________________________________________________________________|____________|

   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Basophilic Focus                     |          X                                                               |      1     |

      Eosinophilic Focus                   |          X                                                               |      1     |

      Inflammation, Chronic Active         | 1  1  1  1  1  1  2  2  1  2                                             |     10  1.3|

      Bile Duct, Hyperplasia               |       1        1                                                         |      2  1.0|

      Hepatocyte, Degeneration             | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|

      Hepatocyte, Hypertrophy              | 3  3  2  3  3  3  3  3  3  3                                             |     10  2.9|

      Oval Cell, Hyperplasia               | 3  3  3  2  2  2  3  3  3  3                                             |     10  2.7|

                                           |__________________________________________________________________________|____________|

   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  12                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |

    300                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM - cont                  |                                                                          |            |

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Atrophy                              |    1                                                                     |      1  1.0|

      Infiltration Cellular,               |                                                                          |            |

          Polymorphonuclear                |                1                                                         |      1  1.0|

      Mineralization                       |    1     1                                                               |      2  1.0|

      Epithelium, Glands, Degeneration     |                         1                                                |      1  1.0|

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Subcapsular, Hyperplasia             | 2  1  1  1  2  1  2  2  2  2                                             |     10  1.6|

                                           |__________________________________________________________________________|____________|

   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Parathyroid Gland                       | +  +  +  +  M  +  +  +  M  +                                             |   8        |

                                           |__________________________________________________________________________|____________|

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Infiltration Cellular, Lymphocyte    |             2                                                            |      1  2.0|

      Follicle, Cyst                       |             1                                                            |      1  1.0|

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  13                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |

    300                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 GENITAL SYSTEM - cont                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Endometrium, Hyperplasia, Cystic     |    1                                                                     |      1  1.0|

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +                                             |   9        |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Hematopoietic Cell Proliferation     | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

                                           |__________________________________________________________________________|____________|

   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  14                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |

    300                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Olfactory Epithelium, Degeneration   | 2  1  1  1  1  1  1  1  1  1                                             |     10  1.1|

                                           |__________________________________________________________________________|____________|

   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Eye                                     | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Nephropathy                          | 1                                                                        |      1  1.0|

      Papilla, Mineralization              |                         1                                                |      1  1.0|

                                           |__________________________________________________________________________|____________|

   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Infiltration Cellular, Mononuclear   |                                                                          |            |

          Cell                             |                      1                                                   |      1  1.0|

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  15                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                                           | 4| 4| 4| 4| 4| 4| 4| 4| 5| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |

    600                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Inflammation                         |                   1                                                      |      1  1.0|

                                           |__________________________________________________________________________|____________|

   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Inflammation                         |                            2                                             |      1  2.0|

                                           |__________________________________________________________________________|____________|

   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Inflammation                         |                            2                                             |      1  2.0|

                                           |__________________________________________________________________________|____________|

   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Fatty Change, Diffuse                |       1     1     1     3  2                                             |      5  1.6|

      Inflammation, Chronic Active         |                         2  2                                             |      2  2.0|

      Necrosis                             | 3  4  4  3  4  4  4  4  2  2                                             |     10  3.4|

      Oval Cell, Hyperplasia               | 1     1  2              2  1                                             |      5  1.4|

                                           |__________________________________________________________________________|____________|

   Mesentery                               |    +  +                                                                  |   2        |

      Fat, Inflammation                    |    3                                                                     |      1  3.0|

      Fat, Necrosis                        |       1                                                                  |      1  1.0|

                                           |__________________________________________________________________________|____________|

   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Cytoplasmic Alteration               | 2  3  2  2  2  2  2  2  3  3                                             |     10  2.3|

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  16                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                                           | 4| 4| 4| 4| 4| 4| 4| 4| 5| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |

    600                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM - cont                  |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Hyperplasia, Squamous                |    2     1  1     2  1  2                                                |      6  1.5|

      Mineralization                       |    3  1           1  1  3  2                                             |      6  1.8|

      Ulcer                                |    3  1  1  2     2     3                                                |      6  2.0|

      Epithelium, Necrosis                 |          2                                                               |      1  2.0|

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Epithelium, Glands, Degeneration     | 1        1     2        2  2                                             |      5  1.6|

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Subcapsular, Hyperplasia             | 1     1        1     1  1  1                                             |      6  1.0|

                                           |__________________________________________________________________________|____________|

   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Parathyroid Gland                       | +  M  +  +  +  +  +  +  M  +                                             |   8        |

                                           |__________________________________________________________________________|____________|

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                                                                                                    

                                                             Page  17                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                                           | 4| 4| 4| 4| 4| 4| 4| 4| 5| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |

    600                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 GENITAL SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Lymph Node                              |          +  +  +                                                         |   3        |

      Mediastinal, Atrophy                 |                2                                                         |      1  2.0|

      Mediastinal, Infiltration Cellular,  |                                                                          |            |

           Histiocyte                      |          1                                                               |      1  1.0|

      Pancreatic, Atrophy                  |             3                                                            |      1  3.0|

      Renal, Atrophy                       |          4                                                               |      1  4.0|

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mandibular                  | M  M  +  +  +  +  +  +  +  +                                             |   8        |

      Atrophy                              |       2  2  2  3     2  2  1                                             |      7  2.0|

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Atrophy                              | 2  4  4  4  4  4     3  4  2                                             |      9  3.4|

      Infiltration Cellular,               |                                                                          |            |

          Polymorphonuclear                |                         2                                                |      1  2.0|

                                           |__________________________________________________________________________|____________|

   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Hematopoietic Cell Proliferation     |    1        1                                                            |      2  1.0|

      Lymphoid Follicle, Atrophy           | 3  2  3  2  3  3  2  3  3  1                                             |     10  2.5|

      Red Pulp, Depletion Cellular         | 2  2  2  1  2  3  3  2  1                                                |      9  2.0|

                                           |__________________________________________________________________________|____________|

   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Necrosis, Lymphoid                   | 4  4  4  4  4  4  4  4  4  4                                             |     10  4.0|

 _____________________________________________________________________________________________________________________|            |

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                                                                                                    

                                                             Page  18                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                                           | 4| 4| 4| 4| 4| 4| 4| 4| 5| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |

    600                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Congestion                           |                         2                                                |      1  2.0|

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Olfactory Epithelium, Degeneration   | 4  3  4  4  4  3  3  3  3  3                                             |     10  3.4|

                                           |__________________________________________________________________________|____________|

   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Eye                                     | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Nephropathy                          |             1                                                            |      1  1.0|

                                           |__________________________________________________________________________|____________|

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  19                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                                           | 4| 4| 4| 4| 4| 4| 4| 4| 5| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |

    600                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 URINARY SYSTEM - cont                     |                                                                          |            |

   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  20                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |

                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Infiltration Cellular, Mixed Cell    |          1                                                               |      1  1.0|

                                           |__________________________________________________________________________|____________|

   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Hematopoietic Cell Proliferation     |       1                                                                  |      1  1.0|

      Inflammation, Chronic Active         |    1     1                                                               |      2  1.0|

                                           |__________________________________________________________________________|____________|

   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Mineralization                       |          1                                                               |      1  1.0|

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Infiltration Cellular,               |                                                                          |            |

          Polymorphonuclear                | 2  1           1                                                         |      3  1.3|

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  21                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |

                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Subcapsular, Hyperplasia             |       1        1  1     1  1                                             |      5  1.0|

                                           |__________________________________________________________________________|____________|

   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Epididymis                              | +  +  +  +  +  +  +  +     +                                             |   9        |

                                           |__________________________________________________________________________|____________|

   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Ectasia                              |                2                                                         |      1  2.0|

                                           |__________________________________________________________________________|____________|

   Prostate                                | M  +  +  +  +  +  +  +  +  +                                             |   9        |

                                           |__________________________________________________________________________|____________|

   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  22                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |

                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 GENITAL SYSTEM - cont                     |                                                                          |            |

   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Hematopoietic Cell Proliferation     | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

                                           |__________________________________________________________________________|____________|

   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M                                             |            |

                                           |__________________________________________________________________________|____________|

   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  23                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |

                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 RESPIRATORY SYSTEM - cont                 |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Inflammation                         |    1                                                                     |      1  1.0|

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Eye                                     | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Nephropathy                          | 1              1        1                                                |      3  1.0|

      Papilla, Mineralization              |                            1                                             |      1  1.0|

      Renal Tubule, Vacuolization          |                                                                          |            |

          Cytoplasmic                      | 1  1  1  2  1  2  1     1  1                                             |      9  1.2|

                                           |__________________________________________________________________________|____________|

   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Inflammation                         |             1                                                            |      1  1.0|

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  24                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    37.5                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Inflammation, Chronic Active         |                1     1                                                   |      2  1.0|

                                           |__________________________________________________________________________|____________|

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Dilatation                           | 1                                                                        |      1  1.0|

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Hematopoietic Cell Proliferation     | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  25                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    37.5                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 NERVOUS SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Nephropathy                          | 1  1  1           1        1                                             |      5  1.0|

      Renal Tubule, Vacuolization          |                                                                          |            |

          Cytoplasmic                      |    1  1  1  1  1  1  1  1  1                                             |      9  1.0|

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  26                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    75                                     | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Inflammation, Chronic Active         |    1        1  1           1                                             |      4  1.0|

                                           |__________________________________________________________________________|____________|

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Hematopoietic Cell Proliferation     | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  27                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    75                                     | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 NERVOUS SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Olfactory Epithelium, Degeneration   |    2                                                                     |      1  2.0|

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Nephropathy                          |    1                    1                                                |      2  1.0|

      Papilla, Mineralization              |                   1                                                      |      1  1.0|

      Renal Tubule, Vacuolization          |                                                                          |            |

          Cytoplasmic                      |             1        1                                                   |      2  1.0|

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  28                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    150                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Inflammation, Chronic Active         | 1              1  1  1                                                   |      4  1.0|

                                           |__________________________________________________________________________|____________|

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Hematopoietic Cell Proliferation     | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  29                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    150                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 NERVOUS SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Olfactory Epithelium, Degeneration   |          1                 1                                             |      2  1.0|

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Nephropathy                          | 1           1     1  1                                                   |      4  1.0|

      Renal Tubule, Vacuolization          |                                                                          |            |

          Cytoplasmic                      |                      1                                                   |      1  1.0|

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  30                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    300                                    | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Inflammation, Chronic Active         |    1  1     1  1  1     1  1                                             |      7  1.0|

      Hepatocyte, Degeneration             |       1  1     1     1  1                                                |      5  1.0|

      Hepatocyte, Hypertrophy              | 1  1  1  1  1  2  1  1                                                   |      8  1.1|

      Oval Cell, Hyperplasia               | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Mineralization                       | 2                                                                        |      1  2.0|

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Hematopoietic Cell Proliferation     | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                                                                                                    

                                                             Page  31                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    300                                    | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Olfactory Epithelium, Degeneration   | 1  1  1  1  2  1  1  1  2  1                                             |     10  1.2|

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Nephropathy                          | 1        1     1        1                                                |      4  1.0|

      Papilla, Mineralization              |                   1                                                      |      1  1.0|

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  32                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 6| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 1| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    600                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Eosinophilic Focus                   |                      X                                                   |      1     |

      Inflammation, Chronic Active         | 1  1     1     1  1     1  1                                             |      7  1.0|

      Hepatocyte, Degeneration             | 2  1  1  2  2  1  2  2  2  1                                             |     10  1.6|

      Hepatocyte, Hypertrophy              | 3  2  2  3  3  2  3  3  3  3                                             |     10  2.7|

      Oval Cell, Hyperplasia               | 4  1     3  3  1  2  3  3  1                                             |      9  2.3|

                                           |__________________________________________________________________________|____________|

   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Cytoplasmic Alteration               |                      2                                                   |      1  2.0|

                                           |__________________________________________________________________________|____________|

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Hyperplasia, Squamous                |       3                                                                  |      1  3.0|

      Inflammation                         |       1                                                                  |      1  1.0|

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  33                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 6| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 1| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    600                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM - cont                  |                                                                          |            |

      Epithelium, Glands, Atrophy          |                      2                                                   |      1  2.0|

      Epithelium, Glands, Degeneration     |                      2                                                   |      1  2.0|

      Glands, Ectasia                      |                      1                                                   |      1  1.0|

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Subcapsular, Hyperplasia             | 1  1  1  1  1     1                                                      |      6  1.0|

                                           |__________________________________________________________________________|____________|

   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  M                                             |   8        |

      Cyst                                 |    X                                                                     |      1     |

                                           |__________________________________________________________________________|____________|

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  34                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 6| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 1| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    600                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 GENITAL SYSTEM - cont                     |                                                                          |            |

      Atrophy                              |                      2                                                   |      1  2.0|

                                           |__________________________________________________________________________|____________|

   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Atrophy                              |                      3                                                   |      1  3.0|

                                           |__________________________________________________________________________|____________|

   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Atrophy                              |                      2                                                   |      1  2.0|

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Atrophy                              |                      4                                                   |      1  4.0|

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Atrophy                              |                      4                                                   |      1  4.0|

                                           |__________________________________________________________________________|____________|

   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Hematopoietic Cell Proliferation     | 1  1     1  1  1  1     1  1                                             |      8  1.0|

      Lymphoid Follicle, Atrophy           |                      3                                                   |      1  3.0|

                                           |__________________________________________________________________________|____________|

   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Atrophy                              |                      4                                                   |      1  4.0|

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M                                             |            |

                                           |__________________________________________________________________________|____________|

   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  35                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 6| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 1| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    600                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Venule, Infiltration Cellular, Mixed |                                                                          |            |

          Cell                             |                1                                                         |      1  1.0|

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Congestion, Diffuse                  |                      2                                                   |      1  2.0|

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Inflammation                         |       2                                                                  |      1  2.0|

      Olfactory Epithelium, Degeneration   | 2  2  3  2  1  1  1  2  1  1                                             |     10  1.6|

                                           |__________________________________________________________________________|____________|

   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Eye                                     | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Infiltration Cellular, Mononuclear   |                                                                          |            |

          Cell                             |                         1                                                |      1  1.0|

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Nephropathy                          |             1  1                                                         |      2  1.0|

                                           |__________________________________________________________________________|____________|

   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  36                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 08:01:36    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 6| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 1| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    600                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 URINARY SYSTEM - cont                     |                                                                          |            |

      Infiltration Cellular, Mononuclear   |                                                                          |            |

          Cell                             |                   1                                                      |      1  1.0|

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  37                                                               

                                                                                                                                   

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                             ----------              END OF REPORT             ----------                                           

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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.