Share This:
https://ntp.niehs.nih.gov/go/40981

E03 - Initial and Current Body Weight (Rats)

NTP  EXP/TEST: 60946-01                                    ESTRAGOLE                                              PAGE: 1

TEST TYPE: SUBCHRON 90-DAY                      INITIAL AND CURRENT BODY WEIGHT                                   DATE: 10/08/03

ROUTE: GAVAGE                                                                                                     TIME: 09:08:25



                                                         EIS REPORT 03

                                                           FINAL/RATS





       FACILITY:  Battelle Columbus Laboratory



       NTP C#:  C60946



       CONTRACT NUMBER:  NO1-ES-15460



       CAS NUMBER:  140-67-0



       ANIMAL SUPPLIER:  TACONIC FARMS



       CAGE RANGE:  ALL



       DATE RANGE: ALL



       REASONS FOR REMOVAL:    ALL



       REMOVAL DATE RANGE:     ALL



       TREATMENT GROUPS:       INCLUDE ALL



NTP  EXP/TEST: 60946-01                                    ESTRAGOLE                                              PAGE: 2

TEST TYPE: SUBCHRON 90-DAY                      INITIAL AND CURRENT BODY WEIGHT                                   DATE: 10/08/03

ROUTE: GAVAGE                                               EISRPT03                                              TIME: 09:08:25

----------------------------------------------------------------------------------------------------------------------------------

 SPECIES-STRAIN: F 344-RATS                 SEX: FEMALE      WEEK ON DOSE: 14     FIRST DOSE: 09/11/01

----------------------------------------------------------------------------------------------------------------------------------

                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------

TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD



 0 MG/KG            10     81.7    5.7        10    192.6   12.0                     10    110.9   11.2



 37.5    MG/KG      10     82.4    6.6        10    192.9   11.4       100.1         10    110.6    8.3



 75      MG/KG      10     82.7    6.6        10    191.0    9.1        99.1         10    108.4    9.2



 150     MG/KG      10     83.1    6.2        10    186.2    5.3        96.6         10    103.1    6.2



 300     MG/KG      10     82.9    5.3        10    177.3    8.3        92.0         10     94.3    8.1



 600     MG/KG      10     83.0    6.7        10    168.1   10.5        87.2         10     85.1    7.2









----------------------------------------------------------------------------------------------------------------------------------

 SPECIES-STRAIN: F 344-RATS                 SEX: MALE        WEEK ON DOSE: 14     FIRST DOSE: 09/10/01

----------------------------------------------------------------------------------------------------------------------------------

                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------

TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD



 0 MG/KG            10     89.6    6.7        10    327.0   16.2                     10    237.4   15.0



 37.5    MG/KG      10     89.7    7.4        10    332.5   14.1       101.6         10    242.7   10.5



 75      MG/KG      10     89.2    6.8        10    329.4   10.8       100.7         10    240.2   11.3



 150     MG/KG      10     89.3    6.7        10    315.9   13.0        96.6         10    226.6   10.7



 300     MG/KG      10     88.1    8.1        10    277.6   13.4        84.8         10    189.5   12.5



 600     MG/KG      10     89.1    6.5        10    238.1   10.5        72.8         10    149.0   10.1



                                               -----------------------------------

                                               ---------- END-OF-REPORT ----------

                                               -----------------------------------