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E41 - Mean Body Weights and Survival Table (Mice)

                                                                                                                                   

NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  

LAB: Battelle Columbus                                     ESTRAGOLE                                                DATE: 10/20/03  

EXPERIMENT: 60946 TEST: 02                                                                                        TIME: 10:21:23    

                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        

TEST TYPE: SUBCHRON 90-DAY                          ROUTE: GAVAGE                                                 NTP:  C60946      

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               REASONS FOR REMOVAL:    ALL                                                                                          

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

               REMOVAL DATE RANGE:     ALL                                                                                          

                                                                                                                                    

               TREATMENT GROUPS:       INCLUDE ALL                                                                                  

                                                                                                                                   

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  

LAB: BATTELLE COLUMBUS                                ESTRAGOLE                                                   DATE: 10/20/03    

EXPERIMENT: 60946 TEST: 02                                                                                        TIME: 10:23:22    

SPECIES: MICE, B6C3F1                                                                                                               

TEST TYPE: SUBCHRONIC (90-DAY)                      ROUTE: ORAL GAVAGE                                            NTP:  C60946      

CONT: NO1-ES-15460                                                                                                CAS: 140-67-0     

                                                                                                                                   

                                                                                                                                    

                                   MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE                                               

                                   SUBCHRONIC (90-DAY) ORAL GAVAGE STUDY OF ESTRAGOLE                                               

==========================================================================================================================          

WEEK     0 MG/KG                37.5    MG/KG            75      MG/KG            150     MG/KG            300     MG/KG            

         ----------------       ----------------         ----------------         ----------------         ----------------         

          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.      

         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)     

==================================================================================================================================  

  B        22.2       10        22.5    101.4    10      22.2    100.0    10      22.5    101.4    10      22.5    101.4    10      

  1        22.2       10        22.5    101.4    10      22.2    100.0    10      22.5    101.4    10      22.5    101.4    10      

  2        23.3       10        23.6    101.3    10      23.1     99.1    10      23.9    102.6    10      23.5    100.9    10      

  3        24.3       10        24.4    100.4    10      24.7    101.6    10      24.5    100.8    10      24.6    101.2    10      

  4        25.9       10        26.2    101.2    10      26.5    102.3    10      26.1    100.8    10      25.9    100.0    10      

  5        27.2       10        27.6    101.5    10      27.9    102.6    10      27.7    101.8    10      27.4    100.7    10      

  6        28.2       10        28.9    102.5    10      29.2    103.5    10      28.2    100.0    10      27.8     98.6    10      

  7        28.8       10        30.0    104.2    10      29.7    103.1    10      29.7    103.1    10      28.7     99.7    10      

  8        30.1       10        30.9    102.7    10      30.9    102.7    10      29.9     99.3    10      27.5     91.4    10      

  9        30.9       10        31.3    101.3    10      31.7    102.6    10      30.6     99.0    10      28.3     91.6    10      

 10        32.1       10        32.6    101.6    10      32.4    100.9    10      31.6     98.4    10      28.6     89.1    10      

 11        33.0       10        33.2    100.6    10      33.7    102.1    10      32.2     97.6    10      28.6     86.7    10      

 12        34.7       10        35.6    102.6    10      36.1    104.0    10      33.8     97.4    10      29.4     84.7    10      

 13        36.1       10        36.3    100.6    10      37.2    103.0    10      34.5     95.6    10      30.6     84.8    10      

TERM. SAC.            10                         10                       10                       10                       10      

==========================================================================================================================          

    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   

        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        

    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              

    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    

    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 

         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              

                                                                                                                                   

                                                                                                                                    

MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE                                                                                  

SUBCHRONIC (90-DAY) ORAL GAVAGE STUDY OF ESTRAGOLE                                                                                  

===============================                                                                                                     

     600     MG/KG                                                                                                                  

WEEK ----------------                                                                                                               

      AV.WT.  PERCENT  NO.                                                                                                          

     (GRAMS)  OF CNTL  (A)                                                                                                          

==============================                                                                                                      

  B    22.4    100.9    10                                                                                                          

  1    22.4    100.9    10                                                                                                          

  2    22.1     94.8    10                                                                                                          

  3    23.1     95.1    10                                                                                                          

  4    23.7     91.5    10                                                                                                          

  5    23.9     87.9    10                                                                                                          

  6    25.1     89.0    10                                                                                                          

  7    25.0     86.8    10                                                                                                          

  8    25.5     84.7    10                                                                                                          

  9    25.9     83.8    10                                                                                                          

 10    26.9     83.8     9                                                                                                          

 11    27.1     82.1     9                                                                                                          

 12    27.8     80.1     9                                                                                                          

 13    28.4     78.7     9                                                                                                          

TERM. SAC.               9                                                                                                          

===============================                                                                                                     

    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   

        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        

    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              

    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    

    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 

         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              

                                                                                                                                   

                                                                                                                                    

                                   MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE                                             

                                   SUBCHRONIC (90-DAY) ORAL GAVAGE STUDY OF ESTRAGOLE                                               

==========================================================================================================================          

WEEK     0 MG/KG                37.5    MG/KG            75      MG/KG            150     MG/KG            300     MG/KG            

         ----------------       ----------------         ----------------         ----------------         ----------------         

          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.      

         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)     

==================================================================================================================================  

  B        18.3       10        18.1     98.9    10      18.0     98.4    10      18.2     99.5    10      18.2     99.5    10      

  1        18.3       10        18.1     98.9    10      18.0     98.4    10      18.2     99.5    10      18.2     99.5    10      

  2        18.5       10        19.2    103.8    10      18.8    101.6    10      18.8    101.6    10      18.2     98.4    10      

  3        19.7       10        20.0    101.5    10      19.7    100.0    10      19.9    101.0    10      18.8     95.4    10      

  4        21.0       10        21.0    100.0    10      21.1    100.5    10      20.7     98.6    10      19.4     92.4    10      

  5        21.7       10        21.9    100.9    10      21.9    100.9    10      21.7    100.0    10      20.4     94.0    10      

  6        23.1       10        22.8     98.7    10      22.8     98.7    10      22.3     96.5    10      20.9     90.5    10      

  7        24.1       10        23.6     97.9    10      23.8     98.8    10      22.5     93.4    10      21.4     88.8    10      

  8        24.4       10        23.8     97.5    10      23.6     96.7    10      22.9     93.9    10      21.1     86.5    10      

  9        25.0       10        25.2    100.8    10      24.7     98.8    10      23.1     92.4    10      21.2     84.8    10      

 10        26.0       10        25.8     99.2    10      25.3     97.3    10      24.1     92.7    10      21.2     81.5    10      

 11        27.3       10        25.9     94.9    10      25.3     92.7    10      24.0     87.9    10      21.9     80.2    10      

 12        27.9       10        27.8     99.6    10      26.6     95.3    10      25.3     90.7    10      22.9     82.1    10      

 13        29.8       10        28.7     96.3    10      26.6     89.3    10      25.7     86.2    10      24.3     81.5    10      

TERM. SAC.            10                         10                       10                       10                       10      

==========================================================================================================================          

    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   

        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        

    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              

    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    

    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 

         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              

                                                                                                                                   

                                                                                                                                    

MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE                                                                                

SUBCHRONIC (90-DAY) ORAL GAVAGE STUDY OF ESTRAGOLE                                                                                  

===============================                                                                                                     

     600     MG/KG                                                                                                                  

WEEK ----------------                                                                                                               

      AV.WT.  PERCENT  NO.                                                                                                          

     (GRAMS)  OF CNTL  (A)                                                                                                          

==============================                                                                                                      

  B    18.5    101.1    10                                                                                                          

  1    18.5    101.1    10                                                                                                          

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 13                                                                                                                                 

TERM. SAC.               0                                                                                                          

===============================                                                                                                     

    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   

        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        

    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              

    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    

    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 

         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.