National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/40986

P09 - Non-Neoplastic Lesions by Individual Animal (Rats)

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03

Route: GAVAGE                                                                                                     Time: 09:15:18



                                                           FINAL/RATS



       Facility:  Battelle Columbus Laboratory



       Chemical CAS #:  140-67-0



       Lock Date:  09/03/02



       Cage Range:  All



       Reasons For Removal:    All



       Removal Date Range:     All



       Treatment Groups:       Include All









































































                                                              Page   1





NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    0 MG/KG                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |

                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Hepatodiaphragmatic Nodule           | X        X                                                               |      2     |

      Inflammation, Chronic                |       1     1     1        1                                             |      4  1.0|

                                           |__________________________________________________________________________|____________|

   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Myocardium, Infiltration Cellular,   |                                                                          |            |

           Mononuclear Cell                |       1        1                                                         |      2  1.0|

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page   2                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    0 MG/KG                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |

                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ENDOCRINE SYSTEM                          |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Endometrium, Hyperplasia, Cystic     |       1  2        2                                                      |      3  1.7|

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Hyperplasia                          |             1                                                            |      1  1.0|

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M                                             |            |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page   3                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    0 MG/KG                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |

                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |

   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Inflammation, Chronic                |    1  1     1  1        1                                                |      5  1.0|

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Eye                                     | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page   4                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    0 MG/KG                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |

                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 URINARY SYSTEM - cont                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Cortex, Renal Tubule, Mineralization |                   1     1                                                |      2  1.0|

      Papilla, Renal Tubule, Mineralization| 1                 1     1                                                |      3  1.0|

      Renal Tubule, Regeneration           |       1                                                                  |      1  1.0|

                                           |__________________________________________________________________________|____________|

   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page   5                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    37.5                                   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Hepatodiaphragmatic Nodule           |                   X     X                                                |      2     |

      Inflammation, Chronic                | 1     1                 1  1                                             |      4  1.0|

      Bile Duct, Hyperplasia               | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

      Oval Cell, Hyperplasia               | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

      Periportal, Inflammation, Chronic    |    1        1  1     1     1                                             |      5  1.0|

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Necrosis, Focal                      | 1                                                                        |      1  1.0|

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page   6                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    37.5                                   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 NERVOUS SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Inflammation, Chronic                | 1  1     1     1  1        1                                             |      6  1.0|

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Cortex, Renal Tubule, Mineralization |       1                                                                  |      1  1.0|

      Papilla, Renal Tubule, Mineralization|          1  1        1  1                                                |      4  1.0|

      Renal Tubule, Regeneration           |                1        1                                                |      2  1.0|

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page   7                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    75                                     | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Basophilic Focus                     |       X  X              X                                                |      3     |

      Hepatodiaphragmatic Nodule           |       X                 X                                                |      2     |

      Inflammation, Chronic                |    1     1  1     1     1                                                |      5  1.0|

      Mixed Cell Focus                     | X                                                                        |      1     |

      Bile Duct, Hyperplasia               | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

      Oval Cell, Hyperplasia               | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

      Periportal, Inflammation, Chronic    | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Submandibular Gland, Cytoplasmic     |                                                                          |            |

          Alteration                       | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page   8                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    75                                     | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Inflammation, Chronic                |          1        1  1                                                   |      3  1.0|

      Bronchiole, Bronchus, Hyperplasia,   |                                                                          |            |

           Lymphoid                        |          2                                                               |      1  2.0|

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Olfactory Epithelium, Degeneration   |                         1                                                |      1  1.0|

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Cortex, Renal Tubule, Mineralization |             1  1  1     1                                                |      4  1.0|

      Papilla, Renal Tubule, Mineralization|    1  1  1  1  1        1                                                |      6  1.0|

      Renal Tubule, Regeneration           |                1                                                         |      1  1.0|

      Renal Tubule, Epithelium,            |                                                                          |            |

          Regeneration                     |                            1                                             |      1  1.0|

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page   9                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      A     |

    150                                    | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Basophilic Focus                     | X  X        X  X     X  X                                                |      6     |

      Hepatodiaphragmatic Nodule           |                   X                                                      |      1     |

      Inflammation, Chronic                | 1  1  1  1        1     1                                                |      6  1.0|

      Mixed Cell Focus                     |             X  X  X  X  X  X                                             |      6     |

      Bile Duct, Hyperplasia               | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

      Hepatocyte, Hypertrophy              | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

      Oval Cell, Hyperplasia               | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

      Periportal, Infiltration Cellular,   |                                                                          |            |

           Histiocyte                      | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

      Periportal, Inflammation, Chronic    | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

                                           |__________________________________________________________________________|____________|

   Mesentery                               | +                                                                        |   1        |

      Accessory Spleen                     | 1                                                                        |      1  1.0|

      Fat, Necrosis                        | 1                                                                        |      1  1.0|

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Submandibular Gland, Cytoplasmic     |                                                                          |            |

          Alteration                       | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Mineralization                       |          1                                                               |      1  1.0|

      Epithelium, Glands, Atrophy          | 1  1  1     1  1  1  1  1                                                |      8  1.0|

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  10                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      A     |

    150                                    | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Infiltration Cellular, Histiocyte    |             1                                                            |      1  1.0|

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Brain                                   |          +                                                               |   1        |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Inflammation, Chronic                | 1  1  1              1                                                   |      4  1.0|

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Olfactory Epithelium, Degeneration   | 1                       1                                                |      2  1.0|

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Cortex, Renal Tubule, Mineralization | 1  1     1           1                                                   |      4  1.0|

      Papilla, Renal Tubule, Mineralization| 1  1  1  1  1  1  1                                                      |      7  1.0|

      Renal Tubule, Regeneration           |       1                                                                  |      1  1.0|

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  11                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |

    300                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X                                             |     10     |

      Hepatodiaphragmatic Nodule           |             X              X                                             |      2     |

      Inflammation, Chronic                | 1  1     1                                                               |      3  1.0|

      Mixed Cell Focus                     | X  X  X  X  X  X  X  X  X  X                                             |     10     |

      Bile Duct, Hyperplasia               | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|

      Hepatocyte, Hypertrophy              | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|

      Oval Cell, Hyperplasia               | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|

      Periportal, Infiltration Cellular,   |                                                                          |            |

           Histiocyte                      | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|

      Periportal, Inflammation, Chronic    | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Submandibular Gland, Cytoplasmic     |                                                                          |            |

          Alteration                       | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Mineralization                       |                1  1                                                      |      2  1.0|

      Epithelium, Glands, Atrophy          | 1  1  1  2  2  1  1  2  1  1                                             |     10  1.3|

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  12                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |

    300                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Inflammation, Chronic                |    1     1  1  1  1  1  1  1                                             |      8  1.0|

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Olfactory Epithelium, Degeneration   | 2  1  2  2  1  2  1  2  1  2                                             |     10  1.6|

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Infiltration Cellular, Lymphocyte    |    1                                                                     |      1  1.0|

      Cortex, Renal Tubule, Mineralization |    1                                                                     |      1  1.0|

      Medulla, Renal Tubule, Mineralization|                            1                                             |      1  1.0|

      Papilla, Renal Tubule, Mineralization| 1  1  1  1  1  1  1  1  1                                                |      9  1.0|

      Renal Tubule, Regeneration           | 1  1                       1                                             |      3  1.0|

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  13                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |

    600                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X                                             |     10     |

      Cholangiofibrosis                    |                   2                                                      |      1  2.0|

      Clear Cell Focus                     |                      X                                                   |      1     |

      Eosinophilic Focus                   | X  X  X  X  X  X  X  X  X  X                                             |     10     |

      Mixed Cell Focus                     | X  X  X  X  X  X  X  X  X  X                                             |     10     |

      Bile Duct, Hyperplasia               | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|

      Hepatocyte, Hypertrophy              | 4  4  4  4  4  4  4  4  4  4                                             |     10  4.0|

      Oval Cell, Hyperplasia               | 3  3  3  3  3  3  3  3  3  3                                             |     10  3.0|

      Periportal, Infiltration Cellular,   |                                                                          |            |

           Histiocyte                      | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|

      Periportal, Inflammation, Chronic    | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|

                                           |__________________________________________________________________________|____________|

   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Submandibular Gland, Cytoplasmic     |                                                                          |            |

          Alteration                       | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|

                                           |__________________________________________________________________________|____________|

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  14                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |

    600                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM - cont                  |                                                                          |            |

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Epithelium, Glands, Atrophy          | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Infiltration Cellular, Mononuclear   |                                                                          |            |

          Cell                             |                            1                                             |      1  1.0|

      Myocardium, Infiltration Cellular,   |                                                                          |            |

           Mononuclear Cell                |    1     1                                                               |      2  1.0|

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  15                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |

    600                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 GENITAL SYSTEM - cont                     |                                                                          |            |

   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Lymph Node                              |       +           +     +  +                                             |   4        |

      Pancreatic, Hyperplasia, Lymphoid    |       1           3     2  2                                             |      4  2.0|

      Pancreatic, Infiltration Cellular,   |                                                                          |            |

           Histiocyte                      |       2           2     2  3                                             |      4  2.3|

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M                                             |            |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Hyperplasia, Lymphoid                |       1  2     2                                                         |      3  1.7|

      Infiltration Cellular, Histiocyte    |                2                                                         |      1  2.0|

                                           |__________________________________________________________________________|____________|

   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  16                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |

    600                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 NERVOUS SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Inflammation, Chronic                | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Olfactory Epithelium, Degeneration   | 3  2  2  2  2  2  2  2  2  2                                             |     10  2.1|

                                           |__________________________________________________________________________|____________|

   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Eye                                     | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Hyperplasia, Focal                   | 1                                                                        |      1  1.0|

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Infiltration Cellular, Lymphocyte    |          1        1     1                                                |      3  1.0|

      Cortex, Renal Tubule, Mineralization |                            1                                             |      1  1.0|

      Papilla, Renal Tubule, Mineralization|    1  1     1  1     1  1  1                                             |      7  1.0|

      Renal Tubule, Regeneration           |    1     1     1  1  1  1                                                |      6  1.0|

                                           |__________________________________________________________________________|____________|

   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  17                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |

                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Parasite Metazoan                    |                            X                                             |      1     |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Hepatodiaphragmatic Nodule           |                            X                                             |      1     |

      Inflammation, Chronic                |                         1                                                |      1  1.0|

      Centrilobular, Vacuolization         |                                                                          |            |

          Cytoplasmic                      |       1                                                                  |      1  1.0|

                                           |__________________________________________________________________________|____________|

   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  18                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |

                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |

   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Infiltration Cellular, Mononuclear   |                                                                          |            |

          Cell                             |    1           1                                                         |      2  1.0|

      Myocardium, Infiltration Cellular,   |                                                                          |            |

           Mononuclear Cell                |       1  1  1     1     1  1                                             |      6  1.0|

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Hypospermia                          |                         4                                                |      1  4.0|

                                           |__________________________________________________________________________|____________|

   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  19                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |

                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 GENITAL SYSTEM - cont                     |                                                                          |            |

   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Germinal Epithelium, Degeneration    |                         4                                                |      1  4.0|

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M                                             |            |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Inflammation, Chronic                |    1              1  1  1  1                                             |      5  1.0|

                                           |__________________________________________________________________________|____________|

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  20                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |

                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 RESPIRATORY SYSTEM - cont                 |                                                                          |            |

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Eye                                     | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Infiltration Cellular, Lymphocyte    |                      1                                                   |      1  1.0|

      Papilla, Renal Tubule, Mineralization| 1              1     1     1                                             |      4  1.0|

      Renal Tubule, Regeneration           | 1  1     1     1     1  1  1                                             |      7  1.0|

                                           |__________________________________________________________________________|____________|

   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  21                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    37.5                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Hepatodiaphragmatic Nodule           |             X           X  X                                             |      3     |

      Inflammation, Chronic                |       1                 1                                                |      2  1.0|

      Bile Duct, Hyperplasia               | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

      Oval Cell, Hyperplasia               | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

      Periportal, Infiltration Cellular,   |                                                                          |            |

           Histiocyte                      | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

      Periportal, Inflammation, Chronic    | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  22                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    37.5                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Hyperplasia, Lymphoid                |          1                                                               |      1  1.0|

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Inflammation, Chronic                |                1     1  1                                                |      3  1.0|

      Inflammation, Granulomatous          |                            1                                             |      1  1.0|

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Papilla, Renal Tubule, Mineralization|             1              1                                             |      2  1.0|

      Renal Tubule, Regeneration           | 1  1  1  1  1           1  1                                             |      7  1.0|

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  23                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    75                                     | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Inflammation, Chronic                | 1                                                                        |      1  1.0|

      Mixed Cell Focus                     |                   X                                                      |      1     |

      Bile Duct, Hyperplasia               | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

      Hepatocyte, Hypertrophy              | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

      Oval Cell, Hyperplasia               | 1  1  1  1  1  2  1  1  1  1                                             |     10  1.1|

      Periportal, Infiltration Cellular,   |                                                                          |            |

           Histiocyte                      | 1  1  1  1  1  2  1  1  1  1                                             |     10  1.1|

      Periportal, Inflammation, Chronic    | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Submandibular Gland, Cytoplasmic     |                                                                          |            |

          Alteration                       | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Epithelium, Glands, Atrophy          |                         1  1                                             |      2  1.0|

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  24                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    75                                     | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Hyperplasia                          |    1        1  1     1                                                   |      4  1.0|

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Inflammation, Chronic                |       1     1     1  1  1  1                                             |      6  1.0|

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Infiltration Cellular, Lymphocyte    |                            1                                             |      1  1.0|

      Medulla, Renal Tubule, Mineralization|          1                                                               |      1  1.0|

      Papilla, Renal Tubule, Mineralization|    1           1                                                         |      2  1.0|

      Renal Tubule, Cyst                   |          1                                                               |      1  1.0|

      Renal Tubule, Regeneration           | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                                                                                                    

                                                             Page  25                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    150                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Basophilic Focus                     | X           X  X  X  X  X                                                |      6     |

      Clear Cell Focus                     | X        X                 X                                             |      3     |

      Eosinophilic Focus                   |                   X                                                      |      1     |

      Hepatodiaphragmatic Nodule           | X                                                                        |      1     |

      Inflammation, Chronic                | 1                                                                        |      1  1.0|

      Mixed Cell Focus                     |    X  X  X  X  X  X  X  X  X                                             |      9     |

      Bile Duct, Hyperplasia               | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

      Hepatocyte, Hypertrophy              | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|

      Oval Cell, Hyperplasia               | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|

      Periportal, Infiltration Cellular,   |                                                                          |            |

           Histiocyte                      | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|

      Periportal, Inflammation, Chronic    | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|

                                           |__________________________________________________________________________|____________|

   Mesentery                               | +                                                                        |   1        |

                                           |__________________________________________________________________________|____________|

   Oral Mucosa                             |    +                                                                     |   1        |

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Submandibular Gland, Cytoplasmic     |                                                                          |            |

          Alteration                       | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Mineralization                       |                1                                                         |      1  1.0|

      Epithelium, Glands, Atrophy          | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  26                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    150                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 GENITAL SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Germinal Epithelium, Degeneration    |    4  1                                                                  |      2  2.5|

      Germinal Epithelium, Mineralization  |                   1                                                      |      1  1.0|

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Hyperplasia                          |             1     1  1                                                   |      3  1.0|

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Infiltration Cellular, Histiocyte    |       1                                                                  |      1  1.0|

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Inflammation, Chronic                | 1     1  1  1        1  1  1                                             |      7  1.0|

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Inflammation, Chronic                |       1              1                                                   |      2  1.0|

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  27                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    150                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Infiltration Cellular, Lymphocyte    | 1              1                                                         |      2  1.0|

      Cortex, Renal Tubule, Pigmentation   | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

      Papilla, Renal Tubule, Mineralization| 1  1  1  1  1  1        1  1                                             |      8  1.0|

      Renal Tubule, Regeneration           | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  28                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    300                                    | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Angiectasis, Focal                   |    2  1                                                                  |      2  1.5|

      Basophilic Focus                     | X     X  X  X  X  X  X  X  X                                             |      9     |

      Clear Cell Focus                     |                X                                                         |      1     |

      Eosinophilic Focus                   | X  X  X  X  X  X  X  X  X  X                                             |     10     |

      Hepatodiaphragmatic Nodule           | X  X        X                                                            |      3     |

      Inflammation, Chronic                |    1        1              1                                             |      3  1.0|

      Mixed Cell Focus                     | X  X  X  X  X  X  X  X  X  X                                             |     10     |

      Bile Duct, Hyperplasia               | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|

      Hepatocyte, Hypertrophy              | 3  3  3  3  3  3  3  3  3  3                                             |     10  3.0|

      Oval Cell, Hyperplasia               | 3  3  3  3  3  3  3  3  3  3                                             |     10  3.0|

      Periportal, Infiltration Cellular,   |                                                                          |            |

           Histiocyte                      | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|

      Periportal, Inflammation, Chronic    | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Submandibular Gland, Cytoplasmic     |                                                                          |            |

          Alteration                       | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Epithelium, Glands, Atrophy          | 2  2  2  2  2  2  1  1  1  2                                             |     10  1.7|

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Pars Distalis, Chromophobe Cell,     |                                                                          |            |

           Hypertrophy                     | 2  2  2  2  2  1  2  2  2  1                                             |     10  1.8|

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  29                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    300                                    | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 GENITAL SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Bilateral, Hypospermia               | 4  4  4  3  2  4  3  3  4  3                                             |     10  3.4|

                                           |__________________________________________________________________________|____________|

   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Bilateral, Germinal Epithelium,      |                                                                          |            |

          Degeneration                     | 4  4  4  4  4  4  4  4  4  3                                             |     10  3.9|

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Hyperplasia                          | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

                                           |__________________________________________________________________________|____________|

   Lymph Node                              |    +  +     +                                                            |   3        |

      Pancreatic, Hyperplasia, Lymphoid    |    2  2                                                                  |      2  2.0|

      Pancreatic, Infiltration Cellular,   |                                                                          |            |

           Histiocyte                      |    3  3     2                                                            |      3  2.7|

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +        +     +  +  +  +  +                                             |   7        |

      Hyperplasia, Lymphoid                |          3           1                                                   |      2  2.0|

      Infiltration Cellular, Histiocyte    |          3                                                               |      1  3.0|

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  30                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    300                                    | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 RESPIRATORY SYSTEM - cont                 |                                                                          |            |

      Inflammation, Chronic                | 1  1           1  1     1  1                                             |      6  1.0|

      Inflammation, Granulomatous          |       2  1  1  1                                                         |      4  1.3|

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Olfactory Epithelium, Degeneration   | 2  2  1  1  1  1  2     1  1                                             |      9  1.3|

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Infiltration Cellular, Lymphocyte    |          1  1  1  1  1  1  1                                             |      7  1.0|

      Cortex, Renal Tubule, Pigmentation   | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

      Papilla, Renal Tubule, Mineralization| 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

      Renal Tubule, Regeneration           | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  31                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    600                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Inflammation, Chronic                |                      1                                                   |      1  1.0|

                                           |__________________________________________________________________________|____________|

   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Basophilic Focus                     | X  X  X              X  X  X                                             |      6     |

      Cholangiofibrosis                    | 1  4  1  2  3  4  2  4  1  4                                             |     10  2.6|

      Clear Cell Focus                     |                         X                                                |      1     |

      Eosinophilic Focus                   | X  X  X  X  X  X  X  X  X  X                                             |     10     |

      Mixed Cell Focus                     | X     X  X     X  X  X  X  X                                             |      8     |

      Bile Duct, Hyperplasia               | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|

      Hepatocyte, Hypertrophy              | 4  4  4  4  4  4  4  4  4  4                                             |     10  4.0|

      Oval Cell, Hyperplasia               | 3  3  3  3  3  3  3  3  3  3                                             |     10  3.0|

      Periportal, Infiltration Cellular,   |                                                                          |            |

           Histiocyte                      | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|

      Periportal, Inflammation, Chronic    | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|

                                           |__________________________________________________________________________|____________|

   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Acinus, Atrophy                      |                1                                                         |      1  1.0|

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Submandibular Gland, Cytoplasmic     |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  32                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    600                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM - cont                  |                                                                          |            |

          Alteration                       | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|

                                           |__________________________________________________________________________|____________|

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Epithelium, Glands, Atrophy          | 2  2  2  2  3  2  2  2  2  3                                             |     10  2.2|

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Infiltration Cellular, Mononuclear   |                                                                          |            |

          Cell                             | 1     1     1                                                            |      3  1.0|

      Myocardium, Infiltration Cellular,   |                                                                          |            |

           Mononuclear Cell                |          1           1     1                                             |      3  1.0|

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Pars Distalis, Chromophobe Cell,     |                                                                          |            |

           Hypertrophy                     | 2  2  1  2  1  1  2  2  1  2                                             |     10  1.6|

                                           |__________________________________________________________________________|____________|

   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  33                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    600                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 GENITAL SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Bilateral, Hypospermia               | 4  4  4  4  4  4  4  4  4  4                                             |     10  4.0|

                                           |__________________________________________________________________________|____________|

   Preputial Gland                         | +  +  +  +  +  M  +  +  +  +                                             |   9        |

                                           |__________________________________________________________________________|____________|

   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Bilateral, Germinal Epithelium,      |                                                                          |            |

          Degeneration                     | 4  4  4  4  4  4  4  4  4  4                                             |     10  4.0|

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Hyperplasia                          | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|

                                           |__________________________________________________________________________|____________|

   Lymph Node                              | +     +                 +                                                |   3        |

      Pancreatic, Hyperplasia, Lymphoid    | 3     2                 2                                                |      3  2.3|

      Pancreatic, Infiltration Cellular,   |                                                                          |            |

           Histiocyte                      | 3     2                 3                                                |      3  2.7|

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M                                             |            |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Hyperplasia, Lymphoid                |             2     2                                                      |      2  2.0|

      Infiltration Cellular, Histiocyte    |             3                                                            |      1  3.0|

                                           |__________________________________________________________________________|____________|

   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                                                                                                    

                                                             Page  34                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    600                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Inflammation, Chronic                | 1  1  1  1  1  1  1     1                                                |      8  1.0|

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Olfactory Epithelium, Degeneration   | 2  2  2  2  2  2  2  2  3  2                                             |     10  2.1|

                                           |__________________________________________________________________________|____________|

   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Eye                                     | +  +  +  +  +  +  +  +  +  +                                             |  10        |

                                           |__________________________________________________________________________|____________|

   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |

      Cortex, Renal Tubule, Pigmentation   | 2  2  2  2  2  2  2  2  2  2                                             |     10  2.0|

      Papilla, Renal Tubule, Mineralization| 2  2  1  2  2  2  2  2  2  2                                             |     10  1.9|

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                             Page  35                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03    

Route: GAVAGE                                                                                                     Time: 09:15:18    

 __________________________________________________________________________________________________________________________________ 

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |

                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |

 __________________________________________|__________________________________________________________________________|      T (*) |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |

    600                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |

    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |

 _____________________________________________________________________________________________________________________|____________|

 URINARY SYSTEM - cont                     |                                                                          |            |

      Renal Tubule, Regeneration           | 1  1  2     1  1  1  1  1                                                |      8  1.1|

                                           |__________________________________________________________________________|____________|

   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         

  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           

  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      

  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  36                                                               

                                                                                                                                   

                             ------------------------------------------------------------                                           

                             ----------              END OF REPORT             ----------                                           

                             ------------------------------------------------------------                                           


NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.