National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/40988

P11 - Statistical Analysis of Survival Data (Rats)

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     

LAB: Battelle Columbus                                         ESTRAGOLE                                       DATE: 10/08/03       

EXPERIMENT: 60946 TEST: 01                                                                                     TIME: 09:16:31       

TEST TYPE:  SUBCHRON 90-DAY                     CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        

CONT: NO1-ES-15460                              ROUTE: GAVAGE                                                  NTP C#: C60946       

PATHOLOGIST: MISSING                                                                                           CAS: 140-67-0        

------------------------------------------------------------------------------------------------------------------------------------

                                                                                                                                    

                                                             FINAL/RATS                                                             

                                                                                                                                    

                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

               REMOVAL DATE RANGE:     ALL                                                                                          

                                                                                                                                    

               TREATMENT GROUPS:       INCLUDE ALL                                                                                  

                                                                                                                                   

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     

LAB: Battelle Columbus                                         ESTRAGOLE                                       DATE: 10/08/03       

EXPERIMENT: 60946 TEST: 01                                                                                     TIME: 09:16:31       

TEST TYPE:  SUBCHRON 90-DAY                     CAGES FROM 0000 TO LAST CAGE                                                        

CONT: NO1-ES-15460                              ROUTE: GAVAGE                                                  NTP C#: C60946       

PATHOLOGIST: MISSING                                                                                           CAS: 140-67-0        

                                                                                                                                   

                                     ESTRAGOLE                                                                                      

                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        

                                     MALE RATS                                                                                      

                       FIRST TERMINAL SACRIFICE AT 93 DAYS                                                                          

                                                                                                                                    

                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          

 ==================================================================================                                                 

 |                                DOSE = 0 MG/KG                                  |                                                 

 |                             ---------------------                              |                                                 

 |                                                                                |                                                 

 |  TOTAL 10     UNCENSORED DEATHS 0      CENSORED DEATHS 0    TERMINAL 10        |                                                 

 |                                                                                |                                                 

 |  UNCENSORED DEATHS                                                             |                                                 

 |     NONE                                                                       |                                                 

 |  CENSORED DEATHS                                                               |                                                 

 |      NONE                                                                      |                                                 

 |                                                                                |                                                 

 |--------------------------------------------------------------------------------|                                                 

 |                          DOSE = 37.5    MG/KG                                  |                                                 

 |                       ----------------------------                             |                                                 

 |                                                                                |                                                 

 |  TOTAL 10     UNCENSORED DEATHS 0      CENSORED DEATHS 0    TERMINAL 10        |                                                 

 |                                                                                |                                                 

 |  UNCENSORED DEATHS                                                             |                                                 

 |     NONE                                                                       |                                                 

 |  CENSORED DEATHS                                                               |                                                 

 |      NONE                                                                      |                                                 

 |                                                                                |                                                 

 |--------------------------------------------------------------------------------|                                                 

 |                          DOSE = 75      MG/KG                                  |                                                 

 |                       ----------------------------                             |                                                 

 |                                                                                |                                                 

 |  TOTAL 10     UNCENSORED DEATHS 0      CENSORED DEATHS 0    TERMINAL 10        |                                                 

 |                                                                                |                                                 

 |  UNCENSORED DEATHS                                                             |                                                 

 |     NONE                                                                       |                                                 

 |  CENSORED DEATHS                                                               |                                                 

 |      NONE                                                                      |                                                 

 |                                                                                |                                                 

 ==================================================================================                                                 

                                                                                                                                   

                                     ESTRAGOLE                                                                                      

                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        

                                     MALE RATS                                                                                      

                       FIRST TERMINAL SACRIFICE AT 93 DAYS                                                                          

                                                                                                                                    

                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          

 ==================================================================================                                                 

 |                          DOSE = 150     MG/KG                                  |                                                 

 |                       ----------------------------                             |                                                 

 |                                                                                |                                                 

 |  TOTAL 10     UNCENSORED DEATHS 0      CENSORED DEATHS 0    TERMINAL 10        |                                                 

 |                                                                                |                                                 

 |  UNCENSORED DEATHS                                                             |                                                 

 |     NONE                                                                       |                                                 

 |  CENSORED DEATHS                                                               |                                                 

 |      NONE                                                                      |                                                 

 |                                                                                |                                                 

 |--------------------------------------------------------------------------------|                                                 

 |                          DOSE = 300     MG/KG                                  |                                                 

 |                       ----------------------------                             |                                                 

 |                                                                                |                                                 

 |  TOTAL 10     UNCENSORED DEATHS 0      CENSORED DEATHS 0    TERMINAL 10        |                                                 

 |                                                                                |                                                 

 |  UNCENSORED DEATHS                                                             |                                                 

 |     NONE                                                                       |                                                 

 |  CENSORED DEATHS                                                               |                                                 

 |      NONE                                                                      |                                                 

 |                                                                                |                                                 

 |--------------------------------------------------------------------------------|                                                 

 |                          DOSE = 600     MG/KG                                  |                                                 

 |                       ----------------------------                             |                                                 

 |                                                                                |                                                 

 |  TOTAL 10     UNCENSORED DEATHS 0      CENSORED DEATHS 0    TERMINAL 10        |                                                 

 |                                                                                |                                                 

 |  UNCENSORED DEATHS                                                             |                                                 

 |     NONE                                                                       |                                                 

 |  CENSORED DEATHS                                                               |                                                 

 |      NONE                                                                      |                                                 

 |                                                                                |                                                 

 ==================================================================================                                                 

                                                                                                                                   

                                     ESTRAGOLE                                                                                      

                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        

                                     MALE RATS                                                                                      

                       FIRST TERMINAL SACRIFICE AT 93 DAYS                                                                          

 ==================================================================================                                                 

 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |                                                 

 |                                                                                |                                                 

 |--------------------------------------------------------------------------------|                                                 

 |    DOSE                               TIME (DAYS)                              |                                                 

 |                 10    20    30    40    50    60    70    80    90    93 (A)   |                                                 

 |                                                                                |                                                 

 |--------------------------------------------------------------------------------|                                                 

 |           |                                                                    |                                                 

 |0 MG/KG    |   100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0      |                                                 

 |           |                                                                    |                                                 

 |           |                                                                    |                                                 

 |37.5       |   100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0      |                                                 

 |MG/KG      |                                                                    |                                                 

 |           |                                                                    |                                                 

 |75         |   100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0      |                                                 

 |MG/KG      |                                                                    |                                                 

 |           |                                                                    |                                                 

 |150        |   100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0      |                                                 

 |MG/KG      |                                                                    |                                                 

 |           |                                                                    |                                                 

 |300        |   100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0      |                                                 

 |MG/KG      |                                                                    |                                                 

 |           |                                                                    |                                                 

 |600        |   100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0      |                                                 

 |MG/KG      |                                                                    |                                                 

 |           |                                                                    |                                                 

 ==================================================================================                                                 

                                                                                                                                   

                                     ESTRAGOLE                                                                                      

                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        

                                     MALE RATS                                                                                      

                       FIRST TERMINAL SACRIFICE AT 93 DAYS                                                                          

 ===============================================================================================================================    

 |                                               SURVIVAL SUMMARY STATISTICS                                                   |    

 |                                                                                                                             |    

 |                                                                                                                             |    

 |-----------------------------------------------------------------------------------------------------------------------------|    

 |                                                                          DOSE                                               |    

 |                                                                                                                             |    

 |                                0 MG/KG         37.5            75              150             300             600          |    

 |                                                MG/KG           MG/KG           MG/KG           MG/KG           MG/KG        |    

 |-----------------------------------------------------------------------------------------------------------------------------|    

 |SURVIVAL AT END OF STUDY|      100.0%          100.0%          100.0%          100.0%          100.0%          100.0%        |    

 |(KAPLAN-MEIER)          |                                                                                                    |    

 |                        |                                                                                                    |    

 |SIGNIFICANCE (B)        |        -----           -----           -----           -----           -----           -----       |    

 |(LIFE TABLE)            |                                                                                                    |    

 |                        |                                                                                                    |    

 |MEAN DAY OF             |          .               .               .               .               .               .         |    

 |NATURAL DEATHS (C)      |       (  . )          (  . )          (  . )          (  . )          (  . )          (  . )       |    

 |(STANDARD ERROR)        |                                                                                                    |    

 |                        |                                                                                                    |    

 |MEAN LIFE SPAN (D)      |        93.0            93.0            93.0            93.0            93.0            93.0        |    

 |(STANDARD ERROR)        |       ( 0.0)          ( 0.0)          ( 0.0)          ( 0.0)          ( 0.0)          ( 0.0)       |    

 |                        |                                                                                                    |    

 ===============================================================================================================================    

                                                                                                                                    

       (A)  FIRST TERMINAL SACRIFICE                                                                                                

       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.                                                                

            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS                                                                    

            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".                                                                      

       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE                                                               

       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)                                                           

                                                                                                                                   

                                     ESTRAGOLE                                                                                      

                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        

                                    FEMALE RATS                                                                                     

                       FIRST TERMINAL SACRIFICE AT 93 DAYS                                                                          

                                                                                                                                    

                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          

 ==================================================================================                                                 

 |                                DOSE = 0 MG/KG                                  |                                                 

 |                             ---------------------                              |                                                 

 |                                                                                |                                                 

 |  TOTAL 10     UNCENSORED DEATHS 0      CENSORED DEATHS 0    TERMINAL 10        |                                                 

 |                                                                                |                                                 

 |  UNCENSORED DEATHS                                                             |                                                 

 |     NONE                                                                       |                                                 

 |  CENSORED DEATHS                                                               |                                                 

 |      NONE                                                                      |                                                 

 |                                                                                |                                                 

 |--------------------------------------------------------------------------------|                                                 

 |                          DOSE = 37.5    MG/KG                                  |                                                 

 |                       ----------------------------                             |                                                 

 |                                                                                |                                                 

 |  TOTAL 10     UNCENSORED DEATHS 0      CENSORED DEATHS 0    TERMINAL 10        |                                                 

 |                                                                                |                                                 

 |  UNCENSORED DEATHS                                                             |                                                 

 |     NONE                                                                       |                                                 

 |  CENSORED DEATHS                                                               |                                                 

 |      NONE                                                                      |                                                 

 |                                                                                |                                                 

 |--------------------------------------------------------------------------------|                                                 

 |                          DOSE = 75      MG/KG                                  |                                                 

 |                       ----------------------------                             |                                                 

 |                                                                                |                                                 

 |  TOTAL 10     UNCENSORED DEATHS 0      CENSORED DEATHS 0    TERMINAL 10        |                                                 

 |                                                                                |                                                 

 |  UNCENSORED DEATHS                                                             |                                                 

 |     NONE                                                                       |                                                 

 |  CENSORED DEATHS                                                               |                                                 

 |      NONE                                                                      |                                                 

 |                                                                                |                                                 

 ==================================================================================                                                 

                                                                                                                                   

                                     ESTRAGOLE                                                                                      

                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        

                                    FEMALE RATS                                                                                     

                       FIRST TERMINAL SACRIFICE AT 93 DAYS                                                                          

                                                                                                                                    

                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          

 ==================================================================================                                                 

 |                          DOSE = 150     MG/KG                                  |                                                 

 |                       ----------------------------                             |                                                 

 |                                                                                |                                                 

 |  TOTAL 10     UNCENSORED DEATHS 0      CENSORED DEATHS 0    TERMINAL 10        |                                                 

 |                                                                                |                                                 

 |  UNCENSORED DEATHS                                                             |                                                 

 |     NONE                                                                       |                                                 

 |  CENSORED DEATHS                                                               |                                                 

 |      NONE                                                                      |                                                 

 |                                                                                |                                                 

 |--------------------------------------------------------------------------------|                                                 

 |                          DOSE = 300     MG/KG                                  |                                                 

 |                       ----------------------------                             |                                                 

 |                                                                                |                                                 

 |  TOTAL 10     UNCENSORED DEATHS 0      CENSORED DEATHS 0    TERMINAL 10        |                                                 

 |                                                                                |                                                 

 |  UNCENSORED DEATHS                                                             |                                                 

 |     NONE                                                                       |                                                 

 |  CENSORED DEATHS                                                               |                                                 

 |      NONE                                                                      |                                                 

 |                                                                                |                                                 

 |--------------------------------------------------------------------------------|                                                 

 |                          DOSE = 600     MG/KG                                  |                                                 

 |                       ----------------------------                             |                                                 

 |                                                                                |                                                 

 |  TOTAL 10     UNCENSORED DEATHS 0      CENSORED DEATHS 0    TERMINAL 10        |                                                 

 |                                                                                |                                                 

 |  UNCENSORED DEATHS                                                             |                                                 

 |     NONE                                                                       |                                                 

 |  CENSORED DEATHS                                                               |                                                 

 |      NONE                                                                      |                                                 

 |                                                                                |                                                 

 ==================================================================================                                                 

                                                                                                                                   

                                     ESTRAGOLE                                                                                      

                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        

                                    FEMALE RATS                                                                                     

                       FIRST TERMINAL SACRIFICE AT 93 DAYS                                                                          

 ==================================================================================                                                 

 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |                                                 

 |                                                                                |                                                 

 |--------------------------------------------------------------------------------|                                                 

 |    DOSE                               TIME (DAYS)                              |                                                 

 |                 10    20    30    40    50    60    70    80    90    93 (A)   |                                                 

 |                                                                                |                                                 

 |--------------------------------------------------------------------------------|                                                 

 |           |                                                                    |                                                 

 |0 MG/KG    |   100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0      |                                                 

 |           |                                                                    |                                                 

 |           |                                                                    |                                                 

 |37.5       |   100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0      |                                                 

 |MG/KG      |                                                                    |                                                 

 |           |                                                                    |                                                 

 |75         |   100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0      |                                                 

 |MG/KG      |                                                                    |                                                 

 |           |                                                                    |                                                 

 |150        |   100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0      |                                                 

 |MG/KG      |                                                                    |                                                 

 |           |                                                                    |                                                 

 |300        |   100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0      |                                                 

 |MG/KG      |                                                                    |                                                 

 |           |                                                                    |                                                 

 |600        |   100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0      |                                                 

 |MG/KG      |                                                                    |                                                 

 |           |                                                                    |                                                 

 ==================================================================================                                                 

                                                                                                                                   

                                     ESTRAGOLE                                                                                      

                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        

                                    FEMALE RATS                                                                                     

                       FIRST TERMINAL SACRIFICE AT 93 DAYS                                                                          

 ===============================================================================================================================    

 |                                               SURVIVAL SUMMARY STATISTICS                                                   |    

 |                                                                                                                             |    

 |                                                                                                                             |    

 |-----------------------------------------------------------------------------------------------------------------------------|    

 |                                                                          DOSE                                               |    

 |                                                                                                                             |    

 |                                0 MG/KG         37.5            75              150             300             600          |    

 |                                                MG/KG           MG/KG           MG/KG           MG/KG           MG/KG        |    

 |-----------------------------------------------------------------------------------------------------------------------------|    

 |SURVIVAL AT END OF STUDY|      100.0%          100.0%          100.0%          100.0%          100.0%          100.0%        |    

 |(KAPLAN-MEIER)          |                                                                                                    |    

 |                        |                                                                                                    |    

 |SIGNIFICANCE (B)        |        -----           -----           -----           -----           -----           -----       |    

 |(LIFE TABLE)            |                                                                                                    |    

 |                        |                                                                                                    |    

 |MEAN DAY OF             |          .               .               .               .               .               .         |    

 |NATURAL DEATHS (C)      |       (  . )          (  . )          (  . )          (  . )          (  . )          (  . )       |    

 |(STANDARD ERROR)        |                                                                                                    |    

 |                        |                                                                                                    |    

 |MEAN LIFE SPAN (D)      |        93.0            93.0            93.0            93.0            93.0            93.0        |    

 |(STANDARD ERROR)        |       ( 0.0)          ( 0.0)          ( 0.0)          ( 0.0)          ( 0.0)          ( 0.0)       |    

 |                        |                                                                                                    |    

 ===============================================================================================================================    

                                                                                                                                    

       (A)  FIRST TERMINAL SACRIFICE                                                                                                

       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.                                                                

            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS                                                                    

            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".                                                                      

       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE                                                               

       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)                                                           

                                                                                                                                   

                                                             ESTRAGOLE                                                              

                                                    KAPLAN-MEIER SURVIVAL CURVES                                                    

                                                        0 MG/KG          = 1                                                        

                                                        37.5    MG/KG    = 2                                                        

                                                        75      MG/KG    = 3                                                        

                                                        150     MG/KG    = 4                                                        

                                                        300     MG/KG    = 5                                                        

                                                        600     MG/KG    = 6                                                        

                                                                                                                                    

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                                                                                                                    

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.                                           

                         (NOTE: 10 obs hidden.)                                                                                     

                  P     |                                                                                                           

                  E     |                                                                                                           

                  R 200 +                                                                                                           

                  C     |                                                                                                           

                  E     |                                                                                                           

                  N     |                                                                                                           

                  T 100 +  1                                                                                  1                     

                        |                                                                                                           

                  S     |                                                                                                           

                  U     |                                                                                                           

                  R   0 +                                                                                                           

                  V     |                                                                                                           

                  I     ---+----------------------------------------------------------------------------------+--                   

                  V        0                                                                                 14                     

                  A                                                                                                                 

                                                                   WEEK                                                             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                   

                                                             ESTRAGOLE                                                              

                                                    KAPLAN-MEIER SURVIVAL CURVES                                                    

                                                        0 MG/KG          = 1                                                        

                                                        37.5    MG/KG    = 2                                                        

                                                        75      MG/KG    = 3                                                        

                                                        150     MG/KG    = 4                                                        

                                                        300     MG/KG    = 5                                                        

                                                        600     MG/KG    = 6                                                        

                                                                                                                                    

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                                                                                                                    

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.                                           

                         (NOTE: 10 obs hidden.)                                                                                     

                  P     |                                                                                                           

                  E     |                                                                                                           

                  R 200 +                                                                                                           

                  C     |                                                                                                           

                  E     |                                                                                                           

                  N     |                                                                                                           

                  T 100 +  1                                                                                  1                     

                        |                                                                                                           

                  S     |                                                                                                           

                  U     |                                                                                                           

                  R   0 +                                                                                                           

                  V     |                                                                                                           

                  I     ---+----------------------------------------------------------------------------------+--                   

                  V        0                                                                                 14                     

                  A                                                                                                                 

                                                                   WEEK                                                             

                                                                                                                                    

                                                                                                                                    


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