National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/17413

TDMS Study 99034-01 Pathology Tables

NTP  EXP/TEST: 99034-01                     TRANSGENIC MODEL EVALUATION II (BENZENE)                              PAGE: 1
TEST TYPE: SUBCHRON 26-WEEK                     INITIAL AND CURRENT BODY WEIGHT                                   DATE: 11/05/03
ROUTE: GAVAGE                                                                                                     TIME: 14:49:27

                                                         EIS REPORT 03


       FACILITY:  Battelle Columbus Laboratory

       NTP C#:  C99034

       CONTRACT NUMBER:  N01-ES-65406

       CAS NUMBER:  71-43-2

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 99034-01                     TRANSGENIC MODEL EVALUATION II (BENZENE)                              PAGE: 2
TEST TYPE: SUBCHRON 26-WEEK                     INITIAL AND CURRENT BODY WEIGHT                                   DATE: 11/05/03
ROUTE: GAVAGE                                               EISRPT03                                              TIME: 14:49:27
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 SPECIES-STRAIN: TG:P16-INK4A-MICE          SEX: FEMALE      WEEK ON DOSE: 28     FIRST DOSE: 10/29/99
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                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0 MG/KG            15     20.0    1.3        15     30.4    5.5                     15     10.4    5.0

 25 MG/KG           15     20.0    1.4        15     28.7    4.5        94.4         15      8.6    3.8

 50 MG/KG           15     20.0    1.1        15     29.3    3.5        96.3         15      9.3    3.8

 100     MG/KG      15     20.1    1.3        15     29.7    4.2        97.6         15      9.6    4.1

 200     MG/KG      15     20.3    1.2        15     27.3    1.8        89.8         15      7.0    2.1




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 SPECIES-STRAIN: TG:P16-INK4A-MICE          SEX: MALE        WEEK ON DOSE: 28     FIRST DOSE: 10/29/99
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                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0 MG/KG            15     25.4    1.6        15     45.3    5.1                     15     19.8    4.7

 25 MG/KG           15     25.1    1.6        15     40.0    5.7        88.3         15     14.9    4.9

 50 MG/KG           15     24.9    1.4        15     39.3    3.9        86.7         15     14.4    3.1

 100     MG/KG      15     24.8    2.0        15     33.5    3.6        73.9         15      8.7    2.7

 200     MG/KG      15     25.1    2.1        14     32.1    3.5        70.8         14      7.2    2.3

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