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TDMS Study 99036-01 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Battelle Columbus                  TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)                            DATE: 04/21/04  
EXPERIMENT: 99036 TEST: 01                                                                                        TIME: 08:28:09    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: SUBCHRON 26-WEEK                         ROUTE: DOSED FEED                                             NTP:  C99036      
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: BATTELLE COLUMBUS                                TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)            DATE: 04/21/04    
EXPERIMENT: 99036 TEST: 01                                                                                        TIME:  8:34:19    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: SUBCHRONIC (26-WEEK)                     ROUTE: DOSED FEED                                             NTP:  C99036      
CONT: N01-ES-65406                                                                                                CAS: 77-09-08     
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                         
                       SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)                    
==================================================================================================================================  
           0 PPM                      200 PPM                            375 PPM                            750 PPM                 
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  2     4.0    21.0       4.0     21.0    1.00       38      4.2     20.7    1.05       77      4.1     20.9    1.03      146       
  3     4.1    21.4       4.1     21.6    1.00       38      4.2     20.9    1.02       75      3.9     20.8    0.95      142       
  4     4.2    22.4       4.0     21.8    0.95       37      4.0     21.5    0.95       70      4.3     21.6    1.02      150       
  5     4.0    22.8       4.4     22.9    1.10       38      4.1     22.6    1.03       68      4.1     22.2    1.03      138       
  6     4.0    23.8       4.2     23.5    1.05       36      4.5     23.5    1.13       71      4.5     23.3    1.13      143       
  7     4.2    24.5       4.3     24.6    1.02       35      4.3     23.9    1.02       68      4.3     24.4    1.02      134       
  8     4.4    25.4       4.6     25.5    1.05       36      4.7     24.8    1.07       72      4.8     25.4    1.09      142       
  9     4.4    25.8       4.8     26.4    1.09       37      4.9     25.4    1.11       73      4.4     25.9    1.00      127       
 10     4.5    25.9       4.7     26.6    1.04       36      4.4     25.2    0.98       65      4.5     26.2    1.00      130       
 11     4.6    26.9       5.0     27.3    1.09       36      4.8     26.2    1.04       69      4.9     26.8    1.07      137       
 12     4.7    27.0       5.0     28.0    1.06       36      5.0     26.8    1.06       70      5.0     27.5    1.06      136       
 13     4.6    27.8       4.8     28.2    1.04       34      4.6     27.1    1.00       64      4.9     27.9    1.07      133       
 14     4.6    28.9       5.0     29.0    1.09       35      5.0     28.4    1.09       66      5.0     29.3    1.09      128       
 15     4.7    29.4       5.1     29.5    1.09       34      4.7     28.7    1.00       61      4.8     29.8    1.02      121       
 16     4.6    30.5       5.0     31.1    1.09       32      4.9     29.9    1.07       61      4.9     30.1    1.07      123       
 17     5.0    30.4       5.1     31.0    1.02       33      4.8     29.2    0.96       62      5.4     30.5    1.08      132       
 18     5.4    31.8       5.3     32.0    0.98       33      5.4     30.9    1.00       66      5.3     30.9    0.98      130       
 19     5.3    32.6       5.4     32.1    1.02       34      5.5     31.4    1.04       65      5.6     31.9    1.06      133       
 20     4.9    32.4       5.3     32.8    1.08       32      5.3     32.0    1.08       62      5.5     32.1    1.12      129       
 21     5.3    33.0       5.3     33.1    1.00       32      5.2     32.5    0.98       60      5.7     32.4    1.08      132       
 22     5.2    33.7       5.8     33.7    1.12       34      5.4     33.3    1.04       61      5.8     34.3    1.12      127       
 23     5.5    34.0       5.6     34.2    1.02       33      5.7     34.1    1.04       63      5.8     33.8    1.05      128       
 24     5.4    34.1       5.7     34.8    1.06       33      5.5     34.6    1.02       59      5.8     34.3    1.07      127       
 25     5.5    35.2       5.7     35.6    1.04       32      5.7     35.2    1.04       60      5.6     35.1    1.02      119       
 26     5.2    34.3       5.6     36.0    1.08       31      5.6     35.4    1.08       59      5.6     35.9    1.08      117       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    4.3    24.6       4.5     24.8    1.04       36      4.5     24.0    1.04       70      4.5     24.4    1.04      138       
SD(D)   0.2               0.4             0.04        1      0.3             0.05        4      0.4             0.05        7       
CV(E)   5.7               8.1             4.1       3.5      7.5             4.9       5.3      8.0             4.5       4.9       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    5.1    32.3       5.4     32.7    1.05       33      5.3     31.9    1.03       62      5.4     32.3    1.06      127       
SD(D)   0.3               0.3             0.04        1      0.3             0.04        2      0.3             0.04        5       
CV(E)   6.3               5.4             3.9       3.3      6.3             3.8       3.7      6.3             3.7       4.0       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
               FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                                    
SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)                                           
=============================================================================                                                       
                    3000 PPM                         12,000  PPM                                                                    
       ---------------------------------  ---------------------------------                                                         
                         DOSE/                              DOSE/                                                                   
       GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL                                                                  
       FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/                                                         
WEEK   DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)                                                         
=============================================================================                                                       
  2     4.1     20.8     1.03     596      4.2     20.8     1.05    2436                                                            
  3     3.9     21.1     0.95     556      4.2     20.6     1.02    2437                                                            
  4     4.2     21.5     1.00     586      4.0     20.8     0.95    2330                                                            
  5     4.2     22.4     1.05     562      4.2     22.0     1.05    2313                                                            
  6     4.4     23.3     1.10     570      4.1     22.6     1.03    2205                                                            
  7     4.1     24.1     0.98     506      4.4     23.6     1.05    2237                                                            
  8     4.5     25.0     1.02     541      4.4     24.2     1.00    2191                                                            
  9     4.6     25.0     1.05     549      4.3     24.8     0.98    2092                                                            
 10     4.5     25.9     1.00     527      4.4     25.0     0.98    2115                                                            
 11     5.0     26.8     1.09     558      4.9     25.6     1.07    2280                                                            
 12     4.7     27.0     1.00     518      4.6     25.4     0.98    2156                                                            
 13     4.4     27.1     0.96     488      4.8     26.2     1.04    2220                                                            
 14     4.9     28.2     1.07     525      4.6     26.8     1.00    2068                                                            
 15     4.9     28.8     1.04     506      4.5     26.9     0.96    2009                                                            
 16     4.9     29.8     1.07     492      4.4     27.7     0.96    1907                                                            
 17     5.3     29.6     1.06     538      5.1     28.4     1.02    2142                                                            
 18     5.4     30.0     1.00     543      4.9     28.2     0.91    2091                                                            
 19     5.5     29.8     1.04     550      5.0     28.5     0.94    2093                                                            
 20     5.8     31.1     1.18     559      5.2     28.9     1.06    2156                                                            
 21     5.6     31.9     1.06     529      5.1     28.6     0.96    2136                                                            
 22     6.0     32.4     1.15     552      5.2     29.7     1.00    2102                                                            
 23     5.9     32.1     1.07     554      5.4     29.3     0.98    2232                                                            
 24     6.0     32.9     1.11     544      5.2     29.8     0.96    2074                                                            
 25     5.7     32.8     1.04     525      5.3     30.4     0.96    2107                                                            
 26     5.9     33.6     1.13     524      5.1     30.3     0.98    2023                                                            
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    4.4     24.2     1.02     546      4.4     23.5     1.02    2251                                                            
SD(D)   0.3              0.05      32      0.3              0.04     113                                                            
CV(E)   6.8              4.6      5.9      5.9              3.7      5.0                                                            
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    5.5     31.0     1.08     534      5.0     28.7     0.98    2088                                                            
SD(D)   0.4              0.05      20      0.3              0.04      79                                                            
CV(E)   7.5              4.9      3.7      6.3              3.9      3.8                                                            
=============================================================================                                                       
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                       
                       SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)                    
==================================================================================================================================  
           0 PPM                      200 PPM                            375 PPM                            750 PPM                 
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  2     4.0    17.8       4.0     17.4     1.00      46      4.2     17.6     1.05      90      4.1     17.8     1.03     175       
  3     4.4    18.7       4.2     17.8     0.95      47      4.0     18.2     0.91      82      3.8     17.9     0.86     160       
  4     4.0    19.0       4.2     18.5     1.05      45      3.9     18.7     0.98      78      4.0     18.6     1.00     161       
  5     4.1    19.8       4.0     19.3     0.98      41      4.2     19.8     1.02      80      4.0     19.4     0.98     154       
  6     4.1    20.8       4.3     20.4     1.05      42      4.3     19.9     1.05      81      4.5     20.6     1.10     165       
  7     4.4    21.3       4.2     20.9     0.95      40      4.7     21.2     1.07      83      4.3     21.0     0.98     152       
  8     5.2    21.8       4.9     21.9     0.94      45      5.2     21.8     1.00      89      4.8     22.0     0.92     164       
  9     4.7    22.2       5.2     22.1     1.11      47      5.7     22.4     1.21      95      4.5     22.2     0.96     151       
 10     5.1    22.4       5.3     21.6     1.04      49      5.3     22.4     1.04      89      5.2     22.0     1.02     178       
 11     5.2    22.1       5.5     22.3     1.06      50      5.7     23.3     1.10      93      4.8     22.3     0.92     163       
 12     5.1    22.5       5.6     22.4     1.10      50      5.9     23.1     1.16      96      4.8     22.5     0.94     159       
 13     5.1    22.7       5.9     23.0     1.16      51      5.4     23.4     1.06      87      5.2     23.1     1.02     170       
 14     5.5    23.4       6.1     23.1     1.11      53      6.1     23.8     1.11      96      5.2     23.1     0.95     167       
 15     5.1    22.9       5.9     23.1     1.16      51      5.5     23.4     1.08      88      4.8     23.1     0.94     156       
 16     5.3    23.7       6.1     23.5     1.15      52      5.4     24.2     1.02      83      5.1     23.5     0.96     163       
 17     5.4    23.6       5.7     23.8     1.06      48      5.4     23.8     1.00      84      5.4     24.1     1.00     168       
 18     5.8    24.0       5.8     23.8     1.00      49      5.5     24.4     0.95      84      5.3     24.2     0.91     164       
 19     5.9    24.5       6.1     24.4     1.03      50      6.0     24.7     1.02      91      6.1     24.6     1.03     185       
 20     5.4    24.5       6.5     25.0     1.20      52      5.6     25.1     1.04      84      5.8     24.8     1.07     174       
 21     5.4    24.7       5.9     24.8     1.09      48      5.0     25.0     0.93      75      5.4     24.5     1.00     167       
 22     5.7    24.4       6.1     25.6     1.07      48      5.2     24.6     0.91      80      5.6     25.4     0.98     165       
 23     5.8    24.2       5.7     24.8     0.98      46      6.0     25.6     1.03      88      5.4     24.3     0.93     167       
 24     5.7    24.8       6.0     25.0     1.05      48      5.6     25.4     0.98      83      5.9     25.5     1.04     173       
 25     6.2    25.6       6.3     25.6     1.02      50      6.3     26.4     1.02      89      5.8     25.1     0.94     172       
 26     6.3    25.3       6.1     25.5     0.97      48      6.1     26.5     0.97      86      5.6     25.1     0.89     166       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    4.6    20.9       4.8     20.6     1.03      46      4.9     21.0     1.05      87      4.5     20.8     0.98     163       
SD(D)   0.5               0.7              0.07       4      0.7              0.08       6      0.5              0.06       9       
CV(E)  11.1              14.8              6.6      7.7     15.1              7.5      6.8     10.6              6.3      5.3       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    5.6    24.3       6.0     24.5     1.07      49      5.7     24.8     1.00      85      5.5     24.4     0.97     168       
SD(D)   0.4               0.2              0.07       2      0.4              0.06       5      0.4              0.05       7       
CV(E)   6.3               3.7              6.7      4.1      7.1              5.6      6.2      6.4              5.5      4.2       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
               FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                                  
SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)                                           
=============================================================================                                                       
                    3000 PPM                         12,000  PPM                                                                    
       ---------------------------------  ---------------------------------                                                         
                         DOSE/                              DOSE/                                                                   
       GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL                                                                  
       FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/                                                         
WEEK   DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)                                                         
=============================================================================                                                       
  2     4.3     18.0     1.08     724      4.2     17.7     1.05    2840                                                            
  3     3.9     18.2     0.89     637      4.3     18.6     0.98    2782                                                            
  4     3.9     18.5     0.98     636      4.2     19.1     1.05    2644                                                            
  5     4.1     19.8     1.00     619      4.5     19.8     1.10    2731                                                            
  6     4.5     20.8     1.10     648      4.6     20.9     1.12    2646                                                            
  7     4.6     21.4     1.05     649      4.7     21.6     1.07    2622                                                            
  8     4.6     22.0     0.88     623      5.0     22.0     0.96    2714                                                            
  9     4.6     21.7     0.98     639      5.2     22.2     1.11    2800                                                            
 10     5.0     22.0     0.98     683      5.1     22.5     1.00    2700                                                            
 11     4.8     22.3     0.92     646      5.4     23.2     1.04    2779                                                            
 12     4.9     22.7     0.96     654      5.3     23.1     1.04    2750                                                            
 13     5.0     22.8     0.98     663      5.5     23.4     1.08    2829                                                            
 14     5.2     23.1     0.95     677      5.4     23.5     0.98    2741                                                            
 15     5.3     22.7     1.04     695      5.6     23.6     1.10    2830                                                            
 16     5.7     23.6     1.08     721      5.7     23.9     1.08    2861                                                            
 17     5.4     24.1     1.00     678      5.6     24.0     1.04    2778                                                            
 18     5.9     24.0     1.02     737      5.5     24.1     0.95    2755                                                            
 19     5.9     24.4     1.00     726      5.8     24.5     0.98    2862                                                            
 20     6.0     24.7     1.11     727      6.1     25.0     1.13    2927                                                            
 21     5.5     24.3     1.02     682      5.3     24.7     0.98    2568                                                            
 22     6.0     25.2     1.05     709      5.5     24.9     0.96    2664                                                            
 23     5.6     24.6     0.97     687      6.2     25.6     1.07    2908                                                            
 24     6.1     25.2     1.07     726      6.1     25.5     1.07    2873                                                            
 25     6.2     25.3     1.00     731      5.9     25.4     0.95    2798                                                            
 26     6.0     25.1     0.95     719      6.0     25.4     0.95    2850                                                            
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    4.5     20.8     0.98     652      4.8     21.2     1.05    2736                                                            
SD(D)   0.4              0.07      28      0.5              0.05      73                                                            
CV(E)   8.9              6.8      4.3      9.7              4.8      2.7                                                            
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    5.7     24.3     1.02     709      5.7     24.6     1.02    2801                                                            
SD(D)   0.3              0.05      22      0.3              0.06     101                                                            
CV(E)   5.5              4.9      3.1      5.2              6.2      3.6                                                            
=============================================================================                                                       
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                      DIAGNOSTIC TRAILER REPORT                                                                                     
                      FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                             
                      SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)                     
==================================================================================================================================  
           0 PPM                   200 PPM                  375 PPM                  750 PPM                  3000 PPM              
     ----------------------   ----------------------   ----------------------   ----------------------   ----------------------     
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM      
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS     
=================================================================================================================================== 
  B               20.1  15                 20.0  15                 19.9  15                 20.0  15                 19.9  15      
  1               20.1  15                 20.0  15                 19.9  15                 20.0  15                 19.9  15      
  2   4.0  2485   21.0  15     4.0  2482   21.0  15     4.2  2334   20.7  15     4.1  2506   20.9  15     4.1  2475   20.8  15      
  3   4.1  2014   21.4  15     4.1  2539   21.6  15     4.2  2333   20.9  15     3.9  2184   20.8  15     3.9  2535   21.1  15      
  4   4.2  2193   22.4  14     4.0  2348   21.8  15     4.0  2556   21.5  15     4.3  2328   21.6  14     4.2  2366   21.5  15      
  5   4.0  2188   22.8  14     4.4  2515   22.9  15     4.1  2505   22.6  15     4.1  2367   22.2  14     4.2  2515   22.4  15      
  6   4.0  2180   23.8  14     4.2  2536   23.5  15     4.5  2505   23.5  15     4.5  2353   23.3  14     4.4  2490   23.3  15      
  7   4.2  2361   24.5  14     4.3  2505   24.6  15     4.3  2550   23.9  15     4.3  2184   24.4  13     4.1  2520   24.1  15      
  8   4.4  2357   25.4  14     4.6  2535   25.5  15     4.7  2510   24.8  15     4.8  2149   25.4  13     4.5  2505   25.0  15      
  9   4.4  2324   25.8  14     4.8  2490   26.4  15     4.9  2490   25.4  15     4.4  2172   25.9  13     4.6  2535   25.0  15      
 10   4.5  2357   25.9  14     4.7  2565   26.6  15     4.4  2540   25.2  15     4.5  2197   26.2  13     4.5  2500   25.9  15      
 11   4.6  2361   26.9  14     5.0  2333   27.3  15     4.8  2306   26.2  15     4.9  2028   26.8  13     5.0  2505   26.8  15      
 12   4.7  2180   27.0  13     5.0  2490   28.0  15     5.0  2545   26.8  15     5.0  2184   27.5  13     4.7  2541   27.0  15      
 13   4.6  2210   27.8  13     4.8  2352   28.2  15     4.6  2365   27.1  15     4.9  1977   27.9  13     4.4  2507   27.1  15      
 14   4.6  2145   28.9  13     5.0  2520   29.0  15     5.0  2339   28.4  15     5.0  2210   29.3  13     4.9  2546   28.2  15      
 15   4.7  2209   29.4  13     5.1  2560   29.5  15     4.7  2385   28.7  15     4.8  2171   29.8  13     4.9  2490   28.8  15      
 16   4.6  1984   30.5  13     5.0  2307   31.1  15     4.9  2310   29.9  15     4.9  2188   30.1  13     4.9  2544   29.8  15      
 17   5.0  2040   30.4  13     5.1  2550   31.0  15     4.8  2562   29.2  15     5.4  2163   30.5  13     5.3  2158   29.6  15      
 18   5.4  1992   31.8  13     5.3  2490   32.0  15     5.4  2481   30.9  15     5.3  2040   30.9  13     5.4  2553   30.0  15      
 19   5.3  2028   32.6  13     5.4  2565   32.1  15     5.5  2385   31.4  15     5.6  2171   31.9  13     5.5  2171   29.8  15      
 20   4.9  2180   32.4  13     5.3  2158   32.8  15     5.3  2490   32.0  15     5.5  2040   32.1  13     5.8  2546   31.1  15      
 21   5.3  2023   33.0  13     5.3  2525   33.1  15     5.2  2525   32.5  15     5.7  2025   32.4  13     5.6  2366   31.9  15      
 22   5.2  2223   33.7  13     5.8  2530   33.7  15     5.4  2540   33.3  15     5.8  2146   34.3  13     6.0  2475   32.4  15      
 23   5.5  1992   34.0  13     5.6  2342   34.2  15     5.7  2320   34.1  15     5.8  2016   33.8  13     5.9  2338   32.1  15      
 24   5.4  2176   34.1  13     5.7  2545   34.8  15     5.5  2560   34.6  15     5.8  2004   34.3  13     6.0  2520   32.9  15      
 25   5.5  1987   35.2  13     5.7  2141   35.6  15     5.7  2465   35.2  15     5.6  2039   35.1  13     5.7  2550   32.8  15      
 26   5.2  2188   34.3  13     5.6  2520   36.0  15     5.6  2520   35.4  15     5.6  2172   35.9  13     5.9  2521   33.6  15      
 27   5.3   507                5.7   676                5.5   847                5.6   507                6.6   839                 
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           24.2                     24.4                     23.7                     24.1                     23.8          
14 TO 52          32.3                     32.7                     31.9                     32.3                     31.0          
==================================================================================================================================  
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
DIAGNOSTIC TRAILER REPORT                                                                                                           
FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                                                   
SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)                                           
==============================                                                                                                      
        12,000  PPM                                                                                                                 
     ----------------------                                                                                                         
     DAILY FEED  BODY  NUM                                                                                                          
WEEK FEED HOURS   WGT  WGTS                                                                                                         
===============================                                                                                                     
  B               19.6  15                                                                                                          
  1               19.6  15                                                                                                          
  2   4.2  2495   20.8  15                                                                                                          
  3   4.2  2485   20.6  15                                                                                                          
  4   4.0  2562   20.8  15                                                                                                          
  5   4.2  2542   22.0  15                                                                                                          
  6   4.1  2329   22.6  14                                                                                                          
  7   4.4  2352   23.6  14                                                                                                          
  8   4.4  2365   24.2  14                                                                                                          
  9   4.3  2315   24.8  14                                                                                                          
 10   4.4  2379   25.0  14                                                                                                          
 11   4.9  2145   25.6  14                                                                                                          
 12   4.6  2379   25.4  14                                                                                                          
 13   4.8  2149   26.2  14                                                                                                          
 14   4.6  2394   26.8  14                                                                                                          
 15   4.5  2324   26.9  14                                                                                                          
 16   4.4  2371   27.7  14                                                                                                          
 17   5.1  2320   28.4  14                                                                                                          
 18   4.9  2216   28.2  14                                                                                                          
 19   5.0  2370   28.5  14                                                                                                          
 20   5.2  2168   28.9  14                                                                                                          
 21   5.1  2361   28.6  14                                                                                                          
 22   5.2  2145   29.7  14                                                                                                          
 23   5.4  2324   29.3  14                                                                                                          
 24   5.2  2202   29.8  14                                                                                                          
 25   5.3  2385   30.4  14                                                                                                          
 26   5.1  2346   30.3  14                                                                                                          
 27   5.4  1176                                                                                                                     
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           23.2                                                                                                              
14 TO 52          28.7                                                                                                              
==============================                                                                                                      
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
                      DIAGNOSTIC TRAILER REPORT                                                                                     
                      FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                           
                      SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)                     
==================================================================================================================================  
           0 PPM                   200 PPM                  375 PPM                  750 PPM                  3000 PPM              
     ----------------------   ----------------------   ----------------------   ----------------------   ----------------------     
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM      
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS     
=================================================================================================================================== 
  B               16.4  15                 16.4  15                 16.4  15                 16.5  15                 16.5  15      
  1               16.4  15                 16.4  15                 16.4  15                 16.5  15                 16.5  15      
  2   4.0  2486   17.8  15     4.0  2490   17.4  15     4.2  2499   17.6  15     4.1  2505   17.8  15     4.3  2314   18.0  15      
  3   4.4  2347   18.7  15     4.2  2197   17.8  14     4.0  2180   18.2  14     3.8  2520   17.9  15     3.9  2366   18.2  15      
  4   4.0  2525   19.0  15     4.2  2197   18.5  13     3.9  2039   18.7  14     4.0  2505   18.6  15     3.9  2371   18.5  15      
  5   4.1  2520   19.8  15     4.0  2167   19.3  13     4.2  2329   19.8  14     4.0  2523   19.4  15     4.1  2343   19.8  14      
  6   4.1  2520   20.8  15     4.3  2197   20.4  13     4.3  2338   19.9  14     4.5  2525   20.6  15     4.5  2158   20.8  14      
  7   4.4  2520   21.3  15     4.2  2171   20.9  13     4.7  2366   21.2  14     4.3  2352   21.0  15     4.6  2025   21.4  14      
  8   5.2  2530   21.8  15     4.9  2191   21.9  13     5.2  2352   21.8  14     4.8  2310   22.0  15     4.6  2338   22.0  14      
  9   4.7  2488   22.2  15     5.2  2158   22.1  13     5.7  2324   22.4  14     4.5  2514   22.2  15     4.6  2365   21.7  14      
 10   5.1  2525   22.4  15     5.3  2052   21.6  13     5.3  2364   22.4  14     5.2  2366   22.0  15     5.0  2329   22.0  14      
 11   5.2  2530   22.1  15     5.5  2158   22.3  13     5.7  2308   23.3  14     4.8  2370   22.3  15     4.8  2344   22.3  14      
 12   5.1  2181   22.5  15     5.6  1992   22.4  13     5.9  2380   23.1  14     4.8  2352   22.5  15     4.9  2365   22.7  14      
 13   5.1  2380   22.7  15     5.9  2184   23.0  13     5.4  2197   23.4  14     5.2  2310   23.1  15     5.0  2171   22.8  14      
 14   5.5  2475   23.4  15     6.1  1848   23.1  13     6.1  2338   23.8  14     5.2  2550   23.1  15     5.2  1866   23.1  14      
 15   5.1  2380   22.9  15     5.9  2213   23.1  13     5.5  2223   23.4  14     4.8  2338   23.1  15     5.3  2325   22.7  14      
 16   5.3  2153   23.7  15     6.1  1976   23.5  13     5.4  2141   24.2  14     5.1  2352   23.5  15     5.7  2028   23.6  14      
 17   5.4  2380   23.6  15     5.7  2223   23.8  13     5.4  2223   23.8  14     5.4  2493   24.1  15     5.4  2158   24.1  14      
 18   5.8  2491   24.0  15     5.8  2155   23.8  13     5.5  1980   24.4  14     5.3  2380   24.2  15     5.9  2045   24.0  14      
 19   5.9  2535   24.5  15     6.1  1879   24.4  13     6.0  2052   24.7  14     6.1  1837   24.6  15     5.9  2004   24.4  14      
 20   5.4  2508   24.5  15     6.5  2164   25.0  13     5.6  2324   25.1  14     5.8  2556   24.8  15     6.0  2371   24.7  14      
 21   5.4  1852   24.7  15     5.9  2191   24.8  13     5.0  2366   25.0  14     5.4  2197   24.5  15     5.5  2361   24.3  14      
 22   5.7  2220   24.4  15     6.1  2184   25.6  13     5.2  2022   24.6  14     5.6  2475   25.4  15     6.0  2145   25.2  14      
 23   5.8  1992   24.2  15     5.7  2016   24.8  13     6.0  1997   25.6  14     5.4  2016   24.3  15     5.6  2171   24.6  14      
 24   5.7  2180   24.8  15     6.0  1860   25.0  13     5.6  2210   25.4  14     5.9  2171   25.5  15     6.1  1848   25.2  14      
 25   6.2  2315   25.6  15     6.3  1811   25.6  13     6.3  2145   26.4  14     5.8  2040   25.1  15     6.2  2219   25.3  14      
 26   6.3  2352   25.3  15     6.1  2184   25.5  13     6.1  2352   26.5  14     5.6  2338   25.1  15     6.0  2166   25.1  14      
 27   6.3  2535                6.4  2028                6.4  2364                6.2  2360                5.9  2192                 
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           20.6                     20.3                     20.6                     20.5                     20.5          
14 TO 52          24.3                     24.5                     24.8                     24.4                     24.3          
==================================================================================================================================  
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
DIAGNOSTIC TRAILER REPORT                                                                                                           
FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                                                 
SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)                                           
==============================                                                                                                      
        12,000  PPM                                                                                                                 
     ----------------------                                                                                                         
     DAILY FEED  BODY  NUM                                                                                                          
WEEK FEED HOURS   WGT  WGTS                                                                                                         
===============================                                                                                                     
  B               16.5  15                                                                                                          
  1               16.5  15                                                                                                          
  2   4.2  2495   17.7  15                                                                                                          
  3   4.3  2495   18.6  15                                                                                                          
  4   4.2  2561   19.1  15                                                                                                          
  5   4.5  2520   19.8  15                                                                                                          
  6   4.6  2490   20.9  15                                                                                                          
  7   4.7  2520   21.6  15                                                                                                          
  8   5.0  2535   22.0  15                                                                                                          
  9   5.2  2490   22.2  15                                                                                                          
 10   5.1  2540   22.5  15                                                                                                          
 11   5.4  2475   23.2  15                                                                                                          
 12   5.3  2550   23.1  15                                                                                                          
 13   5.5  2319   23.4  15                                                                                                          
 14   5.4  2391   23.5  15                                                                                                          
 15   5.6  2324   23.6  15                                                                                                          
 16   5.7  2545   23.9  15                                                                                                          
 17   5.6  2490   24.0  15                                                                                                          
 18   5.5  2381   24.1  15                                                                                                          
 19   5.8  2548   24.5  15                                                                                                          
 20   6.1  2340   25.0  15                                                                                                          
 21   5.3  2197   24.7  15                                                                                                          
 22   5.5  2310   24.9  15                                                                                                          
 23   6.2  2324   25.6  15                                                                                                          
 24   6.1  2545   25.5  15                                                                                                          
 25   5.9  2385   25.4  15                                                                                                          
 26   6.0  2347   25.4  15                                                                                                          
 27   6.4  2520                                                                                                                     
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           20.8                                                                                                              
14 TO 52          24.6                                                                                                              
==============================                                                                                                      
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.