National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/17399

TDMS Study 99035-01 Pathology Tables

                                                                                                                                   
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: Battelle Columbus                      TRANSGENIC MODEL EVALUATION II (GLYCIDOL)                               DATE: 03/31/04  
EXPERIMENT: 99035 TEST: 01                                                                                        TIME: 13:24:35    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: 26-39 WEEKS                              ROUTE: GAVAGE                                                 NTP:  C99035      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                              FINAL #1                                                              
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: BATTELLE COLUMBUS                                TRANSGENIC MODEL EVALUATION II (GLYCIDOL)                   DATE: 03/31/04    
EXPERIMENT: 99035 TEST: 01                                                                                        TIME: 13:31:05    
SPECIES: MICE, TG:P16-INK4A                                                                                                         
TEST TYPE: 26                                       ROUTE: ORAL GAVAGE                                            NTP:  C99035      
CONT: N01-ES-65406                                                                                                CAS: 556-52-5     
                                                                                                                                   
                                                                                                                                    
                                         MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE                                         
                                 26 ORAL GAVAGE STUDY OF TRANSGENIC MODEL EVALUATION II (GLYCIDOL)                                  
=================================================================================================================================== 
WEEK     0 MG/KG                25 MG/KG                 50 MG/KG                 100     MG/KG            200     MG/KG            
         ----------------       ----------------         ----------------         ----------------         ----------------         
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.      
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)     
==================================================================================================================================  
  B        27.4       15        27.0     98.5    15      27.3     99.6    15      27.1     98.9    15      27.5    100.4    15      
  1        27.4       15        27.0     98.5    15      27.3     99.6    15      27.1     98.9    15      27.5    100.4    15      
  2        27.8       15        28.0    100.7    15      28.2    101.4    15      28.0    100.7    15      28.1    101.1    15      
  3        28.9       15        28.6     99.0    15      29.1    100.7    15      28.7     99.3    15      28.5     98.6    15      
  4        30.3       15        29.6     97.7    15      30.3    100.0    15      29.3     96.7    15      29.4     97.0    15      
  5        31.4       15        30.4     96.8    15      30.4     96.8    15      30.3     96.5    15      29.5     93.9    15      
  6        31.9       15        31.0     97.2    15      31.2     97.8    15      30.7     96.2    15      29.2     91.5    15      
  7        33.0       15        32.7     99.1    15      33.2    100.6    15      32.1     97.3    15      30.2     91.5    15      
  8        33.8       15        33.2     98.2    15      34.0    100.6    15      32.5     96.2    15      30.5     90.2    15      
  9        34.0       15        33.2     97.6    15      34.6    101.8    15      33.1     97.4    15      30.7     90.3    15      
 10        36.2       15        34.1     94.2    15      35.9     99.2    15      34.7     95.9    15      31.5     87.0    15      
 11        36.6       15        35.0     95.6    15      36.0     98.4    15      34.8     95.1    15      31.2     85.2    15      
 12        36.0       15        35.6     98.9    15      37.0    102.8    15      35.3     98.1    15      31.4     87.2    15      
 13        36.4       15        37.0    101.6    15      37.5    103.0    15      36.6    100.5    15      32.7     89.8    15      
 14        38.0       15        37.8     99.5    15      38.4    101.1    15      36.7     96.6    15      32.5     85.5    15      
 15        38.8       15        38.8    100.0    15      39.4    101.5    15      37.5     96.6    15      33.9     87.4    15      
 16        40.4       15        39.4     97.5    15      40.6    100.5    15      38.6     95.5    15      34.0     84.2    15      
 17        41.7       15        40.1     96.2    15      41.7    100.0    15      39.5     94.7    15      34.7     83.2    15      
 18        41.9       15        41.0     97.9    15      42.8    102.1    15      40.1     95.7    15      34.8     83.1    15      
 19        42.6       15        41.0     96.2    15      43.2    101.4    15      39.8     93.4    15      35.0     82.2    15      
 20        43.3       15        41.9     96.8    15      43.2     99.8    15      40.8     94.2    15      35.7     82.4    15      
 21        43.1       15        41.3     95.8    15      42.3     98.1    15      40.8     94.7    15      35.5     82.4    15      
 22        44.3       15        42.8     96.6    15      43.1     97.3    14      42.1     95.0    15      36.8     83.1    15      
 23        44.6       15        42.5     95.3    15      44.6    100.0    14      42.6     95.5    15      37.0     83.0    15      
 24        45.2       15        42.8     94.7    15      44.5     98.5    14      43.2     95.6    15      36.8     81.4    15      
 25        45.4       15        42.7     94.1    15      44.6     98.2    14      43.2     95.2    15      36.4     80.2    15      
 26        45.9       15        43.7     95.2    15      45.0     98.0    14      44.1     96.1    15      37.7     82.1    15      
 27        46.1       15        44.2     95.9    15      45.7     99.1    14      44.0     95.4    15      37.7     81.8    14      
 28        46.0       15        44.5     96.7    15      45.8     99.6    14      44.0     95.7    15      37.7     82.0    14      
 29        46.3       14        44.6     96.3    15      46.3    100.0    14      44.0     95.0    15      37.5     81.0    14      
 30        46.4       14        45.1     97.2    15      46.5    100.2    14      45.0     97.0    14      36.4     78.4    14      
 31        47.8       14        46.1     96.4    15      47.5     99.4    14      45.9     96.0    14      37.4     78.2    12      
 32        47.3       14        46.3     97.9    15      47.3    100.0    14      45.9     97.0    14      39.3     83.1    10      
 33        47.7       14        45.9     96.2    15      46.4     97.3    14      46.5     97.5    14      39.4     82.6    10      
 34        47.5       14        46.3     97.5    15      46.9     98.7    14      46.4     97.7    14      40.0     84.2    10      
 35        47.0       13        46.3     98.5    15      47.2    100.4    14      46.2     98.3    14      38.4     81.7     9      
 36        47.5       13        46.7     98.3    15      46.6     98.1    13      46.6     98.1    14      38.3     80.6     9      
 37        48.0       13        46.9     97.7    14      47.7     99.4    13      46.7     97.3    14      37.7     78.5     9      
 38        48.6       13        47.2     97.1    14      47.8     98.4    13      47.1     96.9    14      37.5     77.2     9      
 39        48.6       13        47.5     97.7    14      48.3     99.4    13      47.2     97.1    14      38.7     79.6     8      
 40        48.7       13        47.9     98.4    14      48.3     99.2    13      47.5     97.5    14      38.5     79.1     8      
TERM. SAC.            13                         14                       13                       14                        7      
=================================================================================================================================== 
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
                                         MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE                                       
                                 26 ORAL GAVAGE STUDY OF TRANSGENIC MODEL EVALUATION II (GLYCIDOL)                                  
=================================================================================================================================== 
WEEK     0 MG/KG                25 MG/KG                 50 MG/KG                 100     MG/KG            200     MG/KG            
         ----------------       ----------------         ----------------         ----------------         ----------------         
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.      
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)     
==================================================================================================================================  
  B        21.3       15        21.5    100.9    15      21.4    100.5    15      21.5    100.9    15      21.6    101.4    15      
  1        21.3       15        21.5    100.9    15      21.4    100.5    15      21.5    100.9    15      21.6    101.4    15      
  2        22.7       15        22.8    100.4    15      22.8    100.4    15      23.0    101.3    15      23.0    101.3    15      
  3        23.5       15        23.5    100.0    15      23.7    100.9    15      23.7    100.9    15      23.3     99.1    15      
  4        24.8       15        24.8    100.0    15      24.5     98.8    15      24.7     99.6    15      24.7     99.6    15      
  5        25.0       15        24.8     99.2    15      24.8     99.2    15      24.7     98.8    15      24.7     98.8    15      
  6        25.0       15        24.7     98.8    15      25.0    100.0    15      24.9     99.6    15      24.8     99.2    15      
  7        26.2       15        25.7     98.1    15      26.0     99.2    15      26.1     99.6    15      25.1     95.8    15      
  8        26.0       15        25.9     99.6    15      25.9     99.6    15      26.0    100.0    15      25.3     97.3    15      
  9        26.2       15        26.0     99.2    15      25.7     98.1    15      25.5     97.3    15      25.8     98.5    15      
 10        27.7       15        27.1     97.8    15      26.8     96.8    15      26.1     94.2    15      26.5     95.7    15      
 11        27.1       15        26.5     97.8    15      26.4     97.4    15      26.1     96.3    15      25.8     95.2    15      
 12        27.2       15        27.0     99.3    15      26.8     98.5    15      26.7     98.2    15      26.1     96.0    15      
 13        28.5       14        27.6     96.8    15      27.0     94.7    15      27.0     94.7    15      26.9     94.4    15      
 14        28.7       14        27.8     96.9    15      27.3     95.1    15      27.3     95.1    15      26.3     91.6    15      
 15        29.4       14        28.2     95.9    15      27.8     94.6    15      27.6     93.9    15      26.9     91.5    15      
 16        30.0       14        29.0     96.7    15      28.2     94.0    15      28.0     93.3    15      26.6     88.7    15      
 17        30.6       14        28.9     94.4    15      28.4     92.8    15      27.9     91.2    15      27.0     88.2    15      
 18        30.5       14        29.0     95.1    15      28.4     93.1    15      28.2     92.5    15      26.7     87.5    15      
 19        30.4       14        29.3     96.4    15      29.0     95.4    15      28.6     94.1    15      26.6     87.5    15      
 20        31.4       14        30.4     96.8    15      29.5     93.9    15      29.5     93.9    15      27.2     86.6    14      
 21        31.9       14        30.1     94.4    15      29.4     92.2    15      29.1     91.2    15      27.1     85.0    14      
 22        33.0       14        30.8     93.3    15      30.3     91.8    15      29.4     89.1    15      27.9     84.5    14      
 23        33.4       14        30.7     91.9    15      30.7     91.9    15      30.3     90.7    15      27.6     82.6    14      
 24        34.1       14        31.4     92.1    15      31.6     92.7    15      30.3     88.9    15      27.7     81.2    14      
 25        33.9       14        31.5     92.9    15      31.3     92.3    15      30.4     89.7    15      27.6     81.4    14      
 26        34.7       14        32.2     92.8    15      31.9     91.9    15      30.6     88.2    15      28.5     82.1    14      
 27        34.8       14        33.3     95.7    15      32.4     93.1    15      30.8     88.5    15      28.4     81.6    14      
 28        36.1       14        33.7     93.4    15      33.1     91.7    15      31.3     86.7    15      28.1     77.8    13      
 29        36.0       14        33.9     94.2    15      33.7     93.6    15      32.0     88.9    15      28.1     78.1    13      
 30        36.6       14        34.0     92.9    15      34.6     94.5    15      32.0     87.4    15      28.6     78.1    13      
 31        38.2       14        35.8     93.7    15      35.9     94.0    15      33.3     87.2    15      29.6     77.5    12      
 32        38.6       14        35.8     92.7    15      36.3     94.0    15      33.2     86.0    15      29.2     75.6    12      
 33        39.4       14        36.2     91.9    15      36.6     92.9    15      33.1     84.0    15      29.7     75.4    12      
 34        39.6       14        36.4     91.9    15      37.2     93.9    14      33.7     85.1    15      29.9     75.5    12      
 35        39.8       14        36.8     92.5    15      37.8     95.0    13      33.7     84.7    15      29.8     74.9    12      
 36        39.2       14        37.7     96.2    14      38.3     97.7    13      34.1     87.0    14      30.2     77.0    11      
 37        39.8       14        37.9     95.2    14      38.3     96.2    13      34.1     85.7    14      29.7     74.6    11      
 38        40.2       14        38.4     95.5    14      38.6     96.0    13      34.3     85.3    14      31.1     77.4    11      
 39        40.9       14        39.0     95.4    14      37.1     90.7    13      34.1     83.4    14      31.1     76.0    11      
 40        41.8       13        39.4     94.3    14      36.6     87.6    13      34.5     82.5    14      31.2     74.6    11      
TERM. SAC.            13                         14                       12                       14                        9      
=================================================================================================================================== 
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.