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TDMS Study 99036-01 Pathology Tables

                                                                                                                                   
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: Battelle Columbus                  TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)                            DATE: 04/21/04  
EXPERIMENT: 99036 TEST: 01                                                                                        TIME: 08:28:21    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: SUBCHRON 26-WEEK                         ROUTE: DOSED FEED                                             NTP:  C99036      
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: BATTELLE COLUMBUS                                TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)            DATE: 04/21/04    
EXPERIMENT: 99036 TEST: 01                                                                                        TIME:  8:33:07    
SPECIES: MICE, TG:P16-INK4A                                                                                                         
TEST TYPE: SUBCHRONIC (26-WEEK)                     ROUTE: DOSED FEED                                             NTP:  C99036      
CONT: N01-ES-65406                                                                                                CAS: 77-09-08     
                                                                                                                                   
                                                                                                                                    
                                   MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE                                               
               SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)                            
==========================================================================================================================          
WEEK     0 PPM                  200 PPM                  375 PPM                  750 PPM                  3000 PPM                 
         ----------------       ----------------         ----------------         ----------------         ----------------         
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.      
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)     
==================================================================================================================================  
  B        20.1       15        20.0     99.5    15      19.9     99.0    15      20.0     99.5    15      19.9     99.0    15      
  1        20.1       15        20.0     99.5    15      19.9     99.0    15      20.0     99.5    15      19.9     99.0    15      
  2        21.0       15        21.0    100.0    15      20.7     98.6    15      20.9     99.5    15      20.8     99.0    15      
  3        21.4       15        21.6    100.9    15      20.9     97.7    15      20.8     97.2    15      21.1     98.6    15      
  4        22.4       14        21.8     97.3    15      21.5     96.0    15      21.6     96.4    14      21.5     96.0    15      
  5        22.8       14        22.9    100.4    15      22.6     99.1    15      22.2     97.4    14      22.4     98.2    15      
  6        23.8       14        23.5     98.7    15      23.5     98.7    15      23.3     97.9    14      23.3     97.9    15      
  7        24.5       14        24.6    100.4    15      23.9     97.6    15      24.4     99.6    13      24.1     98.4    15      
  8        25.4       14        25.5    100.4    15      24.8     97.6    15      25.4    100.0    13      25.0     98.4    15      
  9        25.8       14        26.4    102.3    15      25.4     98.4    15      25.9    100.4    13      25.0     96.9    15      
 10        25.9       14        26.6    102.7    15      25.2     97.3    15      26.2    101.2    13      25.9    100.0    15      
 11        26.9       14        27.3    101.5    15      26.2     97.4    15      26.8     99.6    13      26.8     99.6    15      
 12        27.0       13        28.0    103.7    15      26.8     99.3    15      27.5    101.9    13      27.0    100.0    15      
 13        27.8       13        28.2    101.4    15      27.1     97.5    15      27.9    100.4    13      27.1     97.5    15      
 14        28.9       13        29.0    100.3    15      28.4     98.3    15      29.3    101.4    13      28.2     97.6    15      
 15        29.4       13        29.5    100.3    15      28.7     97.6    15      29.8    101.4    13      28.8     98.0    15      
 16        30.5       13        31.1    102.0    15      29.9     98.0    15      30.1     98.7    13      29.8     97.7    15      
 17        30.4       13        31.0    102.0    15      29.2     96.1    15      30.5    100.3    13      29.6     97.4    15      
 18        31.8       13        32.0    100.6    15      30.9     97.2    15      30.9     97.2    13      30.0     94.3    15      
 19        32.6       13        32.1     98.5    15      31.4     96.3    15      31.9     97.9    13      29.8     91.4    15      
 20        32.4       13        32.8    101.2    15      32.0     98.8    15      32.1     99.1    13      31.1     96.0    15      
 21        33.0       13        33.1    100.3    15      32.5     98.5    15      32.4     98.2    13      31.9     96.7    15      
 22        33.7       13        33.7    100.0    15      33.3     98.8    15      34.3    101.8    13      32.4     96.1    15      
 23        34.0       13        34.2    100.6    15      34.1    100.3    15      33.8     99.4    13      32.1     94.4    15      
 24        34.1       13        34.8    102.1    15      34.6    101.5    15      34.3    100.6    13      32.9     96.5    15      
 25        35.2       13        35.6    101.1    15      35.2    100.0    15      35.1     99.7    13      32.8     93.2    15      
 26        34.3       13        36.0    105.0    15      35.4    103.2    15      35.9    104.7    13      33.6     98.0    15      
TERM. SAC.            13                         15                       15                       13                       15      
==========================================================================================================================          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE                                                                                  
SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)                                           
===============================                                                                                                     
     12,000  PPM                                                                                                                    
WEEK ----------------                                                                                                               
      AV.WT.  PERCENT  NO.                                                                                                          
     (GRAMS)  OF CNTL  (A)                                                                                                          
==============================                                                                                                      
  B    19.6     97.5    15                                                                                                          
  1    19.6     97.5    15                                                                                                          
  2    20.8     99.0    15                                                                                                          
  3    20.6     96.3    15                                                                                                          
  4    20.8     92.9    15                                                                                                          
  5    22.0     96.5    15                                                                                                          
  6    22.6     95.0    14                                                                                                          
  7    23.6     96.3    14                                                                                                          
  8    24.2     95.3    14                                                                                                          
  9    24.8     96.1    14                                                                                                          
 10    25.0     96.5    14                                                                                                          
 11    25.6     95.2    14                                                                                                          
 12    25.4     94.1    14                                                                                                          
 13    26.2     94.2    14                                                                                                          
 14    26.8     92.7    14                                                                                                          
 15    26.9     91.5    14                                                                                                          
 16    27.7     90.8    14                                                                                                          
 17    28.4     93.4    14                                                                                                          
 18    28.2     88.7    14                                                                                                          
 19    28.5     87.4    14                                                                                                          
 20    28.9     89.2    14                                                                                                          
 21    28.6     86.7    14                                                                                                          
 22    29.7     88.1    14                                                                                                          
 23    29.3     86.2    14                                                                                                          
 24    29.8     87.4    14                                                                                                          
 25    30.4     86.4    14                                                                                                          
 26    30.3     88.3    14                                                                                                          
TERM. SAC.              14                                                                                                          
===============================                                                                                                     
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
                                   MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE                                             
               SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)                            
==========================================================================================================================          
WEEK     0 PPM                  200 PPM                  375 PPM                  750 PPM                  3000 PPM                 
         ----------------       ----------------         ----------------         ----------------         ----------------         
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.      
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)     
==================================================================================================================================  
  B        16.4       15        16.4    100.0    15      16.4    100.0    15      16.5    100.6    15      16.5    100.6    15      
  1        16.4       15        16.4    100.0    15      16.4    100.0    15      16.5    100.6    15      16.5    100.6    15      
  2        17.8       15        17.4     97.8    15      17.6     98.9    15      17.8    100.0    15      18.0    101.1    15      
  3        18.7       15        17.8     95.2    14      18.2     97.3    14      17.9     95.7    15      18.2     97.3    15      
  4        19.0       15        18.5     97.4    13      18.7     98.4    14      18.6     97.9    15      18.5     97.4    15      
  5        19.8       15        19.3     97.5    13      19.8    100.0    14      19.4     98.0    15      19.8    100.0    14      
  6        20.8       15        20.4     98.1    13      19.9     95.7    14      20.6     99.0    15      20.8    100.0    14      
  7        21.3       15        20.9     98.1    13      21.2     99.5    14      21.0     98.6    15      21.4    100.5    14      
  8        21.8       15        21.9    100.5    13      21.8    100.0    14      22.0    100.9    15      22.0    100.9    14      
  9        22.2       15        22.1     99.5    13      22.4    100.9    14      22.2    100.0    15      21.7     97.7    14      
 10        22.4       15        21.6     96.4    13      22.4    100.0    14      22.0     98.2    15      22.0     98.2    14      
 11        22.1       15        22.3    100.9    13      23.3    105.4    14      22.3    100.9    15      22.3    100.9    14      
 12        22.5       15        22.4     99.6    13      23.1    102.7    14      22.5    100.0    15      22.7    100.9    14      
 13        22.7       15        23.0    101.3    13      23.4    103.1    14      23.1    101.8    15      22.8    100.4    14      
 14        23.4       15        23.1     98.7    13      23.8    101.7    14      23.1     98.7    15      23.1     98.7    14      
 15        22.9       15        23.1    100.9    13      23.4    102.2    14      23.1    100.9    15      22.7     99.1    14      
 16        23.7       15        23.5     99.2    13      24.2    102.1    14      23.5     99.2    15      23.6     99.6    14      
 17        23.6       15        23.8    100.8    13      23.8    100.8    14      24.1    102.1    15      24.1    102.1    14      
 18        24.0       15        23.8     99.2    13      24.4    101.7    14      24.2    100.8    15      24.0    100.0    14      
 19        24.5       15        24.4     99.6    13      24.7    100.8    14      24.6    100.4    15      24.4     99.6    14      
 20        24.5       15        25.0    102.0    13      25.1    102.4    14      24.8    101.2    15      24.7    100.8    14      
 21        24.7       15        24.8    100.4    13      25.0    101.2    14      24.5     99.2    15      24.3     98.4    14      
 22        24.4       15        25.6    104.9    13      24.6    100.8    14      25.4    104.1    15      25.2    103.3    14      
 23        24.2       15        24.8    102.5    13      25.6    105.8    14      24.3    100.4    15      24.6    101.7    14      
 24        24.8       15        25.0    100.8    13      25.4    102.4    14      25.5    102.8    15      25.2    101.6    14      
 25        25.6       15        25.6    100.0    13      26.4    103.1    14      25.1     98.0    15      25.3     98.8    14      
 26        25.3       15        25.5    100.8    13      26.5    104.7    14      25.1     99.2    15      25.1     99.2    14      
TERM. SAC.            15                         13                       14                       15                       14      
==========================================================================================================================          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE                                                                                
SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)                                           
===============================                                                                                                     
     12,000  PPM                                                                                                                    
WEEK ----------------                                                                                                               
      AV.WT.  PERCENT  NO.                                                                                                          
     (GRAMS)  OF CNTL  (A)                                                                                                          
==============================                                                                                                      
  B    16.5    100.6    15                                                                                                          
  1    16.5    100.6    15                                                                                                          
  2    17.7     99.4    15                                                                                                          
  3    18.6     99.5    15                                                                                                          
  4    19.1    100.5    15                                                                                                          
  5    19.8    100.0    15                                                                                                          
  6    20.9    100.5    15                                                                                                          
  7    21.6    101.4    15                                                                                                          
  8    22.0    100.9    15                                                                                                          
  9    22.2    100.0    15                                                                                                          
 10    22.5    100.4    15                                                                                                          
 11    23.2    105.0    15                                                                                                          
 12    23.1    102.7    15                                                                                                          
 13    23.4    103.1    15                                                                                                          
 14    23.5    100.4    15                                                                                                          
 15    23.6    103.1    15                                                                                                          
 16    23.9    100.8    15                                                                                                          
 17    24.0    101.7    15                                                                                                          
 18    24.1    100.4    15                                                                                                          
 19    24.5    100.0    15                                                                                                          
 20    25.0    102.0    15                                                                                                          
 21    24.7    100.0    15                                                                                                          
 22    24.9    102.0    15                                                                                                          
 23    25.6    105.8    15                                                                                                          
 24    25.5    102.8    15                                                                                                          
 25    25.4     99.2    15                                                                                                          
 26    25.4    100.4    15                                                                                                          
TERM. SAC.              15                                                                                                          
===============================                                                                                                     
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.