Share This:
https://ntp.niehs.nih.gov/go/17441

TDMS Study 99036-01 Pathology Tables

NTP Experiment-Test: 99036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK                 TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)                     Date: 04/21/04
Route: DOSED FEED                                                                                                 Time: 08:32:03

                                                         FINAL #1 MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  77-09-08

       Lock Date:  07/19/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 99036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                 TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)                     Date: 04/21/04    
Route: DOSED FEED                                                                                                 Time: 08:32:03    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P16(INK4A)/(+/-) (C57BL/6) FEMALE         0 PPM        200 PPM      375 PPM      750 PPM      3000 PPM     12,000          
                                                                                                                    PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15           15           15           
  Early Deaths                                                                                                                      
    Natural Death                                                   2                                      1                        
    Moribund Sacrifice                                                           1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                15           13           14           15           14           15           
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15           15           15           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (15)         (14)         (15)         (15)         (15)         (15)         
      Infiltration Cellular, Polymorphonuclear                                   1 (7%)                                             
   Liver                                              (15)         (15)         (15)         (15)         (15)         (15)         
      Basophilic Focus                                                                                                  1 (7%)      
      Inflammation, Chronic                           10 (67%)      8 (53%)     12 (80%)     10 (67%)      7 (47%)      8 (53%)     
      Necrosis, Focal                                  1 (7%)                                                           1 (7%)      
   Stomach, Forestomach                               (15)         (14)         (15)         (15)         (15)         (15)         
      Ulcer                                                                                                1 (7%)                   
   Stomach, Glandular                                 (15)         (14)         (15)         (15)         (15)         (15)         
      Hemorrhage                                                                                           1 (7%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Thyroid Gland                                      (15)         (14)         (15)         (15)         (15)         (15)         
      Inflammation, Granulomatous                      1 (7%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 99036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                 TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)                     Date: 04/21/04    
Route: DOSED FEED                                                                                                 Time: 08:32:03    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P16(INK4A)/(+/-) (C57BL/6) FEMALE         0 PPM        200 PPM      375 PPM      750 PPM      3000 PPM     12,000          
                                                                                                                    PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Ovary                                              (15)         (14)         (15)         (15)         (14)         (15)         
      Cyst                                             1 (7%)       1 (7%)                                 1 (7%)       1 (7%)      
   Uterus                                             (15)         (15)         (15)         (15)         (15)         (15)         
      Endometrium, Hyperplasia, Cystic                15 (100%)    12 (80%)     14 (93%)     15 (100%)    13 (87%)     14 (93%)     
   Vagina                                                                                                              (1)          
      Epithelium, Hyperplasia                                                                                           1 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (15)         (15)         (15)         (15)         (15)         (15)         
      Atrophy                                                       2 (13%)                                2 (13%)                  
      Hematopoietic Cell Proliferation                              1 (7%)                                                          
      Hemorrhage                                                    1 (7%)                                                          
      Hyperplasia, Lymphoid                            4 (27%)      2 (13%)      2 (13%)                   1 (7%)       6 (40%)     
   Lymph Node, Mesenteric                             (15)         (14)         (15)         (15)         (15)         (15)         
      Atrophy                                          1 (7%)       1 (7%)       1 (7%)                    2 (13%)      2 (13%)     
      Hematopoietic Cell Proliferation                                           1 (7%)                                             
      Hyperplasia, Lymphoid                                                      1 (7%)                                             
      Infiltration Cellular, Polymorphonuclear                      1 (7%)                                                          
   Spleen                                             (15)         (14)         (14)         (15)         (15)         (15)         
      Hematopoietic Cell Proliferation                 2 (13%)      5 (36%)      9 (64%)      8 (53%)      7 (47%)     13 (87%)     
      Lymphoid Follicle, Atrophy                                    1 (7%)                                 2 (13%)                  
      Lymphoid Follicle, Hyperplasia                                             1 (7%)                                             
   Thymus                                             (15)         (15)         (15)         (15)         (14)         (15)         
      Atrophy, Diffuse                                              1 (7%)       1 (7%)                    1 (7%)                   
      Hyperplasia, Atypical                                                      1 (7%)                    3 (21%)      5 (33%)     
      Hyperplasia, Lymphoid                            1 (7%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                                            (1)                                                 (1)          
      Hyperplasia                                                   1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 99036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                 TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)                     Date: 04/21/04    
Route: DOSED FEED                                                                                                 Time: 08:32:03    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P16(INK4A)/(+/-) (C57BL/6) FEMALE         0 PPM        200 PPM      375 PPM      750 PPM      3000 PPM     12,000          
                                                                                                                    PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - CONT                                                                                                               
   Brain                                              (15)         (15)         (15)         (15)         (15)         (15)         
      Hemorrhage                                                    1 (7%)                                                          
      Neuron, Necrosis                                                                                     1 (7%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)         (15)         (15)         
      Inflammation, Chronic                            2 (13%)      1 (7%)       1 (7%)       3 (20%)      1 (7%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)         (15)         (15)         
      Hydronephrosis                                                                                       1 (7%)       1 (7%)      
      Nephropathy                                     10 (67%)      6 (40%)      8 (53%)      8 (53%)      7 (47%)     11 (73%)     
      Renal Tubule, Mineralization                     1 (7%)                                                                       
   Ureter                                                                                                              (1)          
      Cyst                                                                                                              1 (100%)    
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 99036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                 TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)                     Date: 04/21/04    
Route: DOSED FEED                                                                                                 Time: 08:32:03    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P16(INK4A)/(+/-) (C57BL/6) MALE           0 PPM        200 PPM      375 PPM      750 PPM      3000 PPM     12,000          
                                                                                                                    PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15           15           15           
  Early Deaths                                                                                                                      
    Natural Death                                      1                                      2                         1           
    Moribund Sacrifice                                 1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                13           15           15           13           15           14           
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15           15           15           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (14)         (15)         (14)         
      Hematopoietic Cell Proliferation                                           1 (7%)                                             
      Inflammation, Chronic                           11 (73%)      8 (53%)      7 (47%)      9 (64%)     10 (67%)      5 (36%)     
   Mesentery                                                       (1)                                                              
      Fat, Necrosis                                                 1 (100%)                                                        
   Stomach, Glandular                                 (14)         (15)         (15)         (14)         (15)         (14)         
      Epithelium, Cyst                                                                        1 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (14)         (15)         (15)         (14)         (15)         (14)         
      Hyperplasia, Focal                                                                      4 (29%)      1 (7%)                   
      Hypertrophy, Focal                               4 (29%)      3 (20%)      1 (7%)       1 (7%)       2 (13%)                  
   Thyroid Gland                                      (14)         (15)         (15)         (14)         (15)         (15)         
      Infiltration Cellular, Polymorphonuclear                                   1 (7%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 99036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                 TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)                     Date: 04/21/04    
Route: DOSED FEED                                                                                                 Time: 08:32:03    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P16(INK4A)/(+/-) (C57BL/6) MALE           0 PPM        200 PPM      375 PPM      750 PPM      3000 PPM     12,000          
                                                                                                                    PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Epididymis                                         (15)         (15)         (15)         (15)         (15)         (15)         
      Hypospermia                                                                1 (7%)                   15 (100%)    14 (93%)     
      Inflammation, Chronic                                                                   1 (7%)                                
      Inflammation, Granulomatous                                                1 (7%)                                             
      Mineralization                                                1 (7%)                                                          
   Testes                                             (15)         (15)         (15)         (15)         (15)         (15)         
      Germinal Epithelium, Atrophy                                  1 (7%)       1 (7%)                   15 (100%)    14 (93%)     
      Interstitial Cell, Hyperplasia                                1 (7%)       1 (7%)                   15 (100%)    14 (93%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (15)         (15)         (15)         (15)         (15)         (15)         
      Hyperplasia                                                   1 (7%)                                                          
   Lymph Node, Mandibular                             (14)         (15)         (15)         (14)         (15)         (13)         
      Hyperplasia, Lymphoid                            2 (14%)      1 (7%)       2 (13%)                   3 (20%)      1 (8%)      
   Lymph Node, Mesenteric                             (14)         (15)         (15)         (14)         (15)         (14)         
      Atrophy                                                       1 (7%)       1 (7%)       1 (7%)                                
      Hyperplasia, Lymphoid                                                      1 (7%)                    2 (13%)      1 (7%)      
   Spleen                                             (14)         (15)         (15)         (14)         (15)         (14)         
      Hematopoietic Cell Proliferation                 2 (14%)      5 (33%)      3 (20%)      1 (7%)       2 (13%)     14 (100%)    
      Infiltration Cellular, Mononuclear Cell          1 (7%)                                                                       
      Pigmentation                                                                                                      1 (7%)      
      Capsule, Fibrosis                                                                                                 1 (7%)      
      Lymphoid Follicle, Atrophy                                                              1 (7%)                                
   Thymus                                             (14)         (15)         (15)         (14)         (15)         (14)         
      Atrophy, Diffuse                                                                        1 (7%)                                
      Hyperplasia, Atypical                                                      1 (7%)                    1 (7%)                   
      Hyperplasia, Lymphoid                                                      1 (7%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 99036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                 TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)                     Date: 04/21/04    
Route: DOSED FEED                                                                                                 Time: 08:32:03    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P16(INK4A)/(+/-) (C57BL/6) MALE           0 PPM        200 PPM      375 PPM      750 PPM      3000 PPM     12,000          
                                                                                                                    PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (14)         (15)         (15)         
      Inflammation, Chronic                                         2 (13%)                   2 (14%)      1 (7%)                   
      Alveolar Epithelium, Hyperplasia                                                                                  1 (7%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (14)         (15)         (15)         (14)         (15)         (15)         
      Nephropathy                                      6 (43%)      7 (47%)      8 (53%)      6 (43%)     15 (100%)    14 (93%)     
      Renal Tubule, Accumulation, Hyaline Droplet                                1 (7%)                                             
      Renal Tubule, Hypertrophy                                                              10 (71%)     15 (100%)    14 (93%)     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------