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TDMS Study 99035-01 Pathology Tables

NTP Experiment-Test: 99035-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/31/04
Route: GAVAGE                                     TRANSGENIC MODEL EVALUATION II (GLYCIDOL)                       Time: 13:23:06

                                                            FINAL #1




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  556-52-5

       Lock Date:  09/24/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 99035-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/31/04    
Route: GAVAGE                                     TRANSGENIC MODEL EVALUATION II (GLYCIDOL)                       Time: 13:23:06    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P16(INK4A)/(+/-) (C57BL/6) FEMALE            0 MG/KG      25 MG/KG     50 MG/KG     100          200                       
                                                                                             MG/KG        MG/KG                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15           15                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 2            1            2            1            4                        
    Natural Death                                                                1                         2                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                13           14           12           14            9                        
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15           15                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)         (15)                      
      Angiectasis, Focal                                                                      1 [1.0]      2 [1.0]                  
      Eosinophilic Focus                                                                                   1                        
      Hematopoietic Cell Proliferation                 2 [1.0]      3 [1.7]      1 [2.0]      1 [1.0]      2 [1.0]                  
      Infiltration Cellular, Lymphoid                               3 [1.7]      1 [1.0]      1 [1.0]      1 [1.0]                  
      Inflammation                                                  1 [1.0]                                                         
      Inflammation, Chronic                           11 [1.0]     10 [1.0]      8 [1.0]      8 [1.0]      7 [1.0]                  
      Mixed Cell Focus                                                           1            1                                     
      Necrosis, Focal                                                            5 [1.6]      2 [1.0]      2 [2.0]                  
      Midzonal, Fatty Change                           1 [2.0]                                                                      
   Stomach, Forestomach                               (15)         (15)         (15)         (15)         (15)                      
      Epithelium, Hyperplasia                                                                 1 [1.0]      4 [1.3]                  
   Stomach, Glandular                                 (15)         (15)         (15)         (15)         (15)                      
      Metaplasia, Squamous                                                       1 [2.0]                                            
      Mineralization                                   4 [1.3]                                             2 [1.0]                  
      Epithelium, Ectasia                                                        1 [1.0]                                            
      Muscularis, Mineralization                                                                           2 [1.5]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (15)         (15)         (15)         (15)         (15)                      
      Inflammation, Chronic                                                                                1 [2.0]                  
      Myocardium, Mineralization                       1 [1.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)         (15)                      
      Hematopoietic Cell Proliferation                              1 [2.0]                                                         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 99035-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/31/04    
Route: GAVAGE                                     TRANSGENIC MODEL EVALUATION II (GLYCIDOL)                       Time: 13:23:06    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P16(INK4A)/(+/-) (C57BL/6) FEMALE            0 MG/KG      25 MG/KG     50 MG/KG     100          200                       
                                                                                             MG/KG        MG/KG                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia, Focal                                            2 [1.0]                                1 [2.0]                  
      Mineralization                                                                                       1 [1.0]                  
      Vacuolization Cytoplasmic, Focal                 1 [1.0]                                                                      
      Subcapsular, Hyperplasia                        15 [1.5]     15 [1.5]     10 [1.5]     14 [1.6]     15 [1.7]                  
   Pituitary Gland                                    (15)         (15)         (15)         (15)         (15)                      
      Necrosis                                                                                             1 [3.0]                  
      Pars Distalis, Hyperplasia, Focal                1 [2.0]      1 [1.0]      2 [1.5]      1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                                                                         (1)                       
      Pigmentation, Melanin                                                                                1 [2.0]                  
   Ovary                                              (15)         (15)         (15)         (15)         (15)                      
      Cyst                                             4 [1.0]                                             2 [2.0]                  
   Uterus                                             (15)         (15)         (15)         (15)         (15)                      
      Endometrium, Hyperplasia, Cystic                13 [1.6]     14 [1.8]     10 [1.9]     14 [1.8]      9 [1.9]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (15)         (15)         (15)         (15)         (15)                      
      Hyperplasia                                                                                          1 [3.0]                  
   Lymph Node                                         (13)         (15)         (15)         (13)         (14)                      
      Lumbar, Hyperplasia, Lymphoid                                 1 [1.0]                                                         
      Mediastinal, Hyperplasia, Lymphoid               2 [2.5]      1 [3.0]                                                         
      Pancreatic, Hyperplasia, Lymphoid                                                                    1 [4.0]                  
      Renal, Hyperplasia, Lymphoid                                                                         1 [4.0]                  
   Lymph Node, Mandibular                             (15)         (15)         (15)         (15)         (15)                      
      Hyperplasia, Lymphoid                            1 [3.0]                                             1 [3.0]                  
   Lymph Node, Mesenteric                             (15)         (15)         (15)         (15)         (15)                      
      Hyperplasia, Lymphoid                                                                   1 [2.0]                               
      Inflammation, Suppurative                        1 [2.0]                                                                      
   Spleen                                             (15)         (15)         (15)         (15)         (15)                      
      Hematopoietic Cell Proliferation                 9 [1.8]      5 [2.8]     10 [2.5]     10 [1.6]     10 [2.1]                  
   Thymus                                             (15)         (15)         (15)         (15)         (15)                      
      Atrophy                                                       2 [2.5]                   1 [2.0]      3 [3.3]                  
      Hyperplasia, Lymphoid                                         1 [2.0]                                                         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 99035-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/31/04    
Route: GAVAGE                                     TRANSGENIC MODEL EVALUATION II (GLYCIDOL)                       Time: 13:23:06    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P16(INK4A)/(+/-) (C57BL/6) FEMALE            0 MG/KG      25 MG/KG     50 MG/KG     100          200                       
                                                                                             MG/KG        MG/KG                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (15)         (15)         (15)         (15)         (15)                      
      Hyperplasia                                                                             1 [2.0]                               
   Skin                                               (15)         (15)         (15)         (15)         (15)                      
      Subcutaneous Tissue, Edema                                                                           1 [2.0]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (15)         (15)         (15)         (15)         (15)                      
      Hyperostosis                                                                            1 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (15)         (15)         (15)         (15)         (15)                      
      Cerebellum, Gliosis                                                                                  1 [2.0]                  
      Cerebellum, Neuronopathy                                                                1 [1.0]      3 [2.7]                  
      Cerebrum, Cyst Epithelial Inclusion                                                                  1                        
      Cerebrum, Hemorrhage                                                                    1 [1.0]                               
      Medulla, Gliosis                                                                                     2 [1.5]                  
      Medulla, Neuronopathy                                                                                3 [2.3]                  
      Thalamus, Gliosis                                                                                    1 [1.0]                  
      Thalamus, Neuronopathy                                                                               3 [3.0]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)         (15)                      
      Inflammation                                     8 [2.0]      8 [1.8]      7 [1.9]      5 [2.2]      3 [1.7]                  
      Inflammation, Granulomatous                      1 [1.0]                                                                      
      Alveolar Epithelium, Hyperplasia, Focal          1 [4.0]      2 [3.0]      1 [3.0]                   1 [1.0]                  
      Arteriole, Inflammation, Acute                   1 [1.0]                                                                      
      Bronchus, Foreign Body                           1 [2.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 99035-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/31/04    
Route: GAVAGE                                     TRANSGENIC MODEL EVALUATION II (GLYCIDOL)                       Time: 13:23:06    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P16(INK4A)/(+/-) (C57BL/6) FEMALE            0 MG/KG      25 MG/KG     50 MG/KG     100          200                       
                                                                                             MG/KG        MG/KG                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)         (15)                      
      Infiltration Cellular, Lymphoid                               1 [3.0]                                                         
      Metaplasia, Osseous                                                                                  1 [1.0]                  
      Nephropathy                                     12 [1.0]     12 [1.0]     10 [1.0]     14 [1.0]      9 [1.0]                  
      Renal Tubule, Accumulation, Hyaline Droplet                                2 [2.5]      1 [2.0]      3 [2.0]                  
   Urinary Bladder                                    (15)         (15)         (15)         (15)         (15)                      
      Inflammation, Chronic                            1 [2.0]                                                                      
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 99035-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/31/04    
Route: GAVAGE                                     TRANSGENIC MODEL EVALUATION II (GLYCIDOL)                       Time: 13:23:06    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P16(INK4A)/(+/-) (C57BL/6) MALE              0 MG/KG      25 MG/KG     50 MG/KG     100          200                       
                                                                                             MG/KG        MG/KG                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15           15                        
  Early Deaths                                                                                                                      
    Natural Death                                      2            1            1            1            3                        
    Moribund Sacrifice                                                           1                         4                        
    Dosing Accident                                                                                        1                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                13           14           13           14            7                        
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15           15                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                                                    (1)                                                 
      Inflammation, Acute                                                        1 [3.0]                                            
   Intestine Small, Jejunum                           (15)         (15)         (15)         (15)         (15)                      
      Peyer's Patch, Hyperplasia, Atypical                          1 [3.0]                                                         
      Peyer's Patch, Hyperplasia, Lymphoid                          1 [2.0]                                                         
   Liver                                              (15)         (15)         (15)         (15)         (15)                      
      Angiectasis, Focal                                                                                   1 [2.0]                  
      Basophilic Focus                                              1                                                               
      Degeneration, Cystic                             1 [1.0]                                                                      
      Eosinophilic Focus                                                                                   1                        
      Fatty Change, Focal                                                                     1 [1.0]                               
      Hematopoietic Cell Proliferation                              1 [1.0]                   2 [1.0]      1 [1.0]                  
      Hemorrhage                                                                 1 [1.0]                                            
      Infiltration Cellular, Lymphoid                  1 [1.0]      2 [1.0]                   2 [1.0]      1 [1.0]                  
      Inflammation, Chronic                            6 [1.0]      9 [1.0]      8 [1.0]      9 [1.0]      2 [1.0]                  
      Mixed Cell Focus                                                                        1                                     
      Necrosis, Focal                                  1 [3.0]      2 [2.0]      2 [2.5]                   5 [2.2]                  
   Mesentery                                                       (1)                                                              
      Fat, Necrosis                                                 1 [3.0]                                                         
   Stomach, Forestomach                               (15)         (15)         (15)         (15)         (15)                      
      Inflammation, Chronic                                                                                1 [3.0]                  
      Ulcer                                                         1 [2.0]                                3 [1.7]                  
      Epithelium, Hyperplasia                                       1 [2.0]      1 [2.0]                   6 [2.5]                  
   Stomach, Glandular                                 (15)         (15)         (15)         (15)         (15)                      
      Inflammation, Chronic                                                      1 [2.0]                                            
      Mineralization                                  10 [1.5]                                5 [1.6]      1 [1.0]                  
      Ulcer                                                                                                1 [2.0]                  
      Epithelium, Hyperplasia                                       1 [1.0]                                                         
      Glands, Ectasia                                                            1 [1.0]                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 99035-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/31/04    
Route: GAVAGE                                     TRANSGENIC MODEL EVALUATION II (GLYCIDOL)                       Time: 13:23:06    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P16(INK4A)/(+/-) (C57BL/6) MALE              0 MG/KG      25 MG/KG     50 MG/KG     100          200                       
                                                                                             MG/KG        MG/KG                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Muscularis, Mineralization                                                              1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (15)         (15)         (15)         (15)         (15)                      
      Infiltration Cellular, Mast Cell                                                                     1 [1.0]                  
      Epicardium, Inflammation, Chronic                1 [1.0]                                                                      
      Myocardium, Degeneration                         2 [1.5]                                2 [1.0]                               
      Myocardium, Mineralization                                                 2 [1.0]      1 [1.0]      5 [1.6]                  
      Myocardium, Necrosis                                                                                 2 [2.5]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (14)         (15)                      
      Hyperplasia, Focal                               1 [1.0]                                1 [2.0]                               
      Subcapsular, Hyperplasia                         1 [1.0]      2 [1.0]      2 [1.0]      3 [1.0]      1 [1.0]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (15)         (15)         (15)         (15)         (15)                      
      Fibrosis                                                      1 [3.0]                                                         
   Preputial Gland                                                              (1)                                                 
      Inflammation, Suppurative                                                  1 [4.0]                                            
   Testes                                             (15)         (15)         (15)         (15)         (15)                      
      Germinal Epithelium, Degeneration                             1 [2.0]                                1 [3.0]                  
      Germinal Epithelium, Mineralization                           1 [1.0]                                                         
      Germinal Epithelium, Necrosis                    1 [1.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (14)         (14)         (15)         (13)         (13)                      
      Mediastinal, Hyperplasia, Lymphoid                            1 [3.0]                                                         
   Lymph Node, Mandibular                             (15)         (15)         (15)         (15)         (15)                      
      Hyperplasia, Lymphoid                                         2 [2.0]                   1 [1.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 99035-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/31/04    
Route: GAVAGE                                     TRANSGENIC MODEL EVALUATION II (GLYCIDOL)                       Time: 13:23:06    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P16(INK4A)/(+/-) (C57BL/6) MALE              0 MG/KG      25 MG/KG     50 MG/KG     100          200                       
                                                                                             MG/KG        MG/KG                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Inflammation, Suppurative                                                  1 [3.0]                                            
      Necrosis                                                                                             1 [3.0]                  
   Lymph Node, Mesenteric                             (15)         (15)         (15)         (14)         (15)                      
      Hematopoietic Cell Proliferation                              1 [2.0]                                                         
      Hyperplasia, Lymphoid                                         2 [2.0]                   1 [3.0]      1 [4.0]                  
      Inflammation, Suppurative                                     1 [2.0]                                1 [3.0]                  
      Necrosis                                                                                             1 [2.0]                  
   Spleen                                             (15)         (15)         (15)         (15)         (15)                      
      Angiectasis                                                                                          1 [2.0]                  
      Atrophy                                                                                 1 [2.0]      2 [1.5]                  
      Hematopoietic Cell Proliferation                 4 [2.0]      7 [1.7]      7 [1.4]      5 [2.0]      5 [2.2]                  
   Thymus                                             (15)         (15)         (15)         (15)         (15)                      
      Atrophy                                          2 [2.0]                   1 [3.0]                   4 [3.0]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (15)         (15)         (15)         (15)         (15)                      
      Ulcer                                                                                                1 [2.0]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (15)         (15)         (15)         (15)         (15)                      
      Hyperostosis                                     1 [1.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (15)         (15)         (15)         (15)         (15)                      
      Mineralization                                   1 [1.0]                                                                      
      Cerebellum, Gliosis                                                                                  2 [1.5]                  
      Cerebellum, Hemorrhage, Focal                                                                        1 [2.0]                  
      Cerebellum, Neuronopathy                                                                             3 [3.3]                  
      Cerebrum, Hemorrhage                                                                                 1 [3.0]                  
      Cerebrum, Necrosis, Focal                                                                            2 [3.0]                  
      Hippocampus, Hemorrhage                                                                              1 [3.0]                  
      Hippocampus, Necrosis                                                      1 [3.0]                   1 [3.0]                  
      Medulla, Gliosis                                                                                     2 [1.0]                  
      Medulla, Neuronopathy                                                                                3 [1.0]                  
      Thalamus, Gliosis                                                                                    2 [1.0]                  
      Thalamus, Neuronopathy                                                                               5 [2.2]                  
   Spinal Cord                                                                               (1)                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 99035-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/31/04    
Route: GAVAGE                                     TRANSGENIC MODEL EVALUATION II (GLYCIDOL)                       Time: 13:23:06    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P16(INK4A)/(+/-) (C57BL/6) MALE              0 MG/KG      25 MG/KG     50 MG/KG     100          200                       
                                                                                             MG/KG        MG/KG                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - CONT                                                                                                               
      Axon, Degeneration                                                                      1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)         (15)                      
      Hemorrhage                                                                                           1 [3.0]                  
      Inflammation                                     3 [2.0]      7 [2.3]      5 [2.4]      4 [2.0]      2 [1.5]                  
      Inflammation, Granulomatous                                                1 [1.0]                                            
      Alveolar Epithelium, Hyperplasia, Focal                       2 [1.0]                   2 [1.0]      2 [1.5]                  
      Bronchiole, Hyperplasia                                                    1 [2.0]                                            
      Vein, Thrombosis                                                           1 [3.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)         (15)                      
      Hydronephrosis                                                                                       1 [4.0]                  
      Infarct                                                                                              1 [2.0]                  
      Nephropathy                                      4 [1.0]      5 [1.0]      5 [1.0]      4 [1.0]      4 [1.0]                  
      Renal Tubule, Accumulation, Hyaline Droplet                                1 [3.0]                   1 [2.0]                  
   Urinary Bladder                                    (15)         (15)         (15)         (15)         (15)                      
      Inflammation, Chronic                                                                                1 [4.0]                  
      Transitional Epithelium, Hyperplasia             1 [2.0]                                                                      
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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