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TDMS Study 99036-01 Pathology Tables

NTP Experiment-Test: 99036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/21/04
Route: DOSED FEED                              TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)                   Time: 08:38:26

                                                         FINAL #1 MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  77-09-08

       Lock Date:  07/19/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 99036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/21/04    
Route: DOSED FEED                              TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)                   Time: 08:38:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P16(INK4A)/(+/-) (C57BL/6) FEMALE            0 PPM        200 PPM      375 PPM      750 PPM      3000 PPM     12,000       
                                                                                                                       PPM          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15           15           15           
  Early Deaths                                                                                                                      
    Natural Death                                                   2                                      1                        
    Moribund Sacrifice                                                           1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                15           13           14           15           14           15           
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15           15           15           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (15)         (14)         (15)         (15)         (15)         (15)         
      Infiltration Cellular, Polymorphonuclear                                   1 [1.0]                                            
   Liver                                              (15)         (15)         (15)         (15)         (15)         (15)         
      Basophilic Focus                                                                                                  1           
      Inflammation, Chronic                           10 [1.0]      8 [1.0]     12 [1.0]     10 [1.0]      7 [1.0]      8 [1.0]     
      Necrosis, Focal                                  1 [1.0]                                                          1 [1.0]     
   Stomach, Forestomach                               (15)         (14)         (15)         (15)         (15)         (15)         
      Ulcer                                                                                                1 [3.0]                  
   Stomach, Glandular                                 (15)         (14)         (15)         (15)         (15)         (15)         
      Hemorrhage                                                                                           1 [1.0]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Thyroid Gland                                      (15)         (14)         (15)         (15)         (15)         (15)         
      Inflammation, Granulomatous                      1 [1.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 99036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/21/04    
Route: DOSED FEED                              TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)                   Time: 08:38:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P16(INK4A)/(+/-) (C57BL/6) FEMALE            0 PPM        200 PPM      375 PPM      750 PPM      3000 PPM     12,000       
                                                                                                                       PPM          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Ovary                                              (15)         (14)         (15)         (15)         (14)         (15)         
      Cyst                                             1 [1.0]      1 [1.0]                                1 [1.0]      1 [1.0]     
   Uterus                                             (15)         (15)         (15)         (15)         (15)         (15)         
      Endometrium, Hyperplasia, Cystic                15 [1.1]     12 [1.2]     14 [1.2]     15 [1.3]     13 [1.2]     14 [1.4]     
   Vagina                                                                                                              (1)          
      Epithelium, Hyperplasia                                                                                           1 [3.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (15)         (15)         (15)         (15)         (15)         (15)         
      Atrophy                                                       2 [2.0]                                2 [2.0]                  
      Hematopoietic Cell Proliferation                              1 [3.0]                                                         
      Hemorrhage                                                    1 [3.0]                                                         
      Hyperplasia, Lymphoid                            4 [1.3]      2 [1.0]      2 [1.0]                   1 [2.0]      6 [1.7]     
   Lymph Node, Mesenteric                             (15)         (14)         (15)         (15)         (15)         (15)         
      Atrophy                                          1 [1.0]      1 [2.0]      1 [1.0]                   2 [2.0]      2 [1.0]     
      Hematopoietic Cell Proliferation                                           1 [1.0]                                            
      Hyperplasia, Lymphoid                                                      1 [1.0]                                            
      Infiltration Cellular, Polymorphonuclear                      1 [2.0]                                                         
   Spleen                                             (15)         (14)         (14)         (15)         (15)         (15)         
      Hematopoietic Cell Proliferation                 2 [1.0]      5 [1.0]      9 [1.1]      8 [1.0]      7 [1.3]     13 [1.0]     
      Lymphoid Follicle, Atrophy                                    1 [4.0]                                2 [4.0]                  
      Lymphoid Follicle, Hyperplasia                                             1 [1.0]                                            
   Thymus                                             (15)         (15)         (15)         (15)         (14)         (15)         
      Atrophy, Diffuse                                              1 [3.0]      1 [3.0]                   1 [3.0]                  
      Hyperplasia, Atypical                                                      1 [3.0]                   3 [2.0]      5 [2.6]     
      Hyperplasia, Lymphoid                            1 [1.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                                            (1)                                                 (1)          
      Hyperplasia                                                   1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 99036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/21/04    
Route: DOSED FEED                              TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)                   Time: 08:38:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P16(INK4A)/(+/-) (C57BL/6) FEMALE            0 PPM        200 PPM      375 PPM      750 PPM      3000 PPM     12,000       
                                                                                                                       PPM          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - CONT                                                                                                               
   Brain                                              (15)         (15)         (15)         (15)         (15)         (15)         
      Hemorrhage                                                    1 [3.0]                                                         
      Neuron, Necrosis                                                                                     1 [2.0]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)         (15)         (15)         
      Inflammation, Chronic                            2 [1.0]      1 [1.0]      1 [1.0]      3 [1.3]      1 [3.0]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)         (15)         (15)         
      Hydronephrosis                                                                                       1 [3.0]      1 [4.0]     
      Nephropathy                                     10 [1.0]      6 [1.0]      8 [1.0]      8 [1.0]      7 [1.0]     11 [1.0]     
      Renal Tubule, Mineralization                     1 [1.0]                                                                      
   Ureter                                                                                                              (1)          
      Cyst                                                                                                              1 [4.0]     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 99036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/21/04    
Route: DOSED FEED                              TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)                   Time: 08:38:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P16(INK4A)/(+/-) (C57BL/6) MALE              0 PPM        200 PPM      375 PPM      750 PPM      3000 PPM     12,000       
                                                                                                                       PPM          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15           15           15           
  Early Deaths                                                                                                                      
    Natural Death                                      1                                      2                         1           
    Moribund Sacrifice                                 1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                13           15           15           13           15           14           
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15           15           15           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (14)         (15)         (14)         
      Hematopoietic Cell Proliferation                                           1 [4.0]                                            
      Inflammation, Chronic                           11 [1.0]      8 [1.0]      7 [1.0]      9 [1.0]     10 [1.0]      5 [1.0]     
   Mesentery                                                       (1)                                                              
      Fat, Necrosis                                                 1 [2.0]                                                         
   Stomach, Glandular                                 (14)         (15)         (15)         (14)         (15)         (14)         
      Epithelium, Cyst                                                                        1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (14)         (15)         (15)         (14)         (15)         (14)         
      Hyperplasia, Focal                                                                      4 [1.5]      1 [2.0]                  
      Hypertrophy, Focal                               4 [1.3]      3 [1.0]      1 [1.0]      1 [1.0]      2 [1.0]                  
   Thyroid Gland                                      (14)         (15)         (15)         (14)         (15)         (15)         
      Infiltration Cellular, Polymorphonuclear                                   1 [1.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 99036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/21/04    
Route: DOSED FEED                              TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)                   Time: 08:38:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P16(INK4A)/(+/-) (C57BL/6) MALE              0 PPM        200 PPM      375 PPM      750 PPM      3000 PPM     12,000       
                                                                                                                       PPM          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Epididymis                                         (15)         (15)         (15)         (15)         (15)         (15)         
      Hypospermia                                                                1 [4.0]                  15 [1.1]     14 [3.0]     
      Inflammation, Chronic                                                                   1 [1.0]                               
      Inflammation, Granulomatous                                                1 [1.0]                                            
      Mineralization                                                1 [1.0]                                                         
   Testes                                             (15)         (15)         (15)         (15)         (15)         (15)         
      Germinal Epithelium, Atrophy                                  1 [1.0]      1 [4.0]                  15 [1.6]     14 [2.6]     
      Interstitial Cell, Hyperplasia                                1 [1.0]      1 [2.0]                  15 [1.5]     14 [1.8]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (15)         (15)         (15)         (15)         (15)         (15)         
      Hyperplasia                                                   1 [4.0]                                                         
   Lymph Node, Mandibular                             (14)         (15)         (15)         (14)         (15)         (13)         
      Hyperplasia, Lymphoid                            2 [1.5]      1 [1.0]      2 [2.0]                   3 [1.0]      1 [2.0]     
   Lymph Node, Mesenteric                             (14)         (15)         (15)         (14)         (15)         (14)         
      Atrophy                                                       1 [1.0]      1 [1.0]      1 [3.0]                               
      Hyperplasia, Lymphoid                                                      1 [1.0]                   2 [1.0]      1 [1.0]     
   Spleen                                             (14)         (15)         (15)         (14)         (15)         (14)         
      Hematopoietic Cell Proliferation                 2 [1.0]      5 [1.4]      3 [2.0]      1 [1.0]      2 [1.0]     14 [1.0]     
      Infiltration Cellular, Mononuclear Cell          1 [3.0]                                                                      
      Pigmentation                                                                                                      1 [2.0]     
      Capsule, Fibrosis                                                                                                 1 [1.0]     
      Lymphoid Follicle, Atrophy                                                              1 [2.0]                               
   Thymus                                             (14)         (15)         (15)         (14)         (15)         (14)         
      Atrophy, Diffuse                                                                        1 [4.0]                               
      Hyperplasia, Atypical                                                      1 [2.0]                   1 [3.0]                  
      Hyperplasia, Lymphoid                                                      1 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 99036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/21/04    
Route: DOSED FEED                              TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)                   Time: 08:38:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P16(INK4A)/(+/-) (C57BL/6) MALE              0 PPM        200 PPM      375 PPM      750 PPM      3000 PPM     12,000       
                                                                                                                       PPM          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (14)         (15)         (15)         
      Inflammation, Chronic                                         2 [1.0]                   2 [1.0]      1 [1.0]                  
      Alveolar Epithelium, Hyperplasia                                                                                  1 [2.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (14)         (15)         (15)         (14)         (15)         (15)         
      Nephropathy                                      6 [1.0]      7 [1.0]      8 [1.0]      6 [1.0]     15 [1.0]     14 [1.4]     
      Renal Tubule, Accumulation, Hyaline Droplet                                1 [3.0]                                            
      Renal Tubule, Hypertrophy                                                              10 [1.0]     15 [1.0]     14 [1.0]     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
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