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TDMS Study 96018-03 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Southern Research Inst           WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                          DATE: 04/29/03  
EXPERIMENT: 96018 TEST: 03                                                                                        TIME: 12:33:29    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED WATER                                            NTP:  C96018      
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                                                            FINAL#1/RATS                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: SOUTHERN RESEARCH INSTITUTE                      WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)        DATE: 04/29/03    
EXPERIMENT: 96018 TEST: 03                                                                                        TIME: 12:41:38    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: CHRONIC                                  ROUTE: DOSED WATER                                            NTP:  C96018      
CONT: N01-ES-85420                                                                                                CAS: 75-27-4      
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY MALE RATS IN THE                                        
                           CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                        
==================================================================================================================================  
           0 MG/L                     175 MG/L                           350 MG/L                           700 MG/L                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  4    16.7   200.6      15.4    194.8    0.92     13.9     15.2    193.6    0.91     27.5     14.7    192.7    0.88     53.3       
  8    17.7   277.6      16.1    269.3    0.91     10.5     15.9    272.0    0.90     20.5     15.8    268.7    0.89     41.3       
 12    16.9   326.5      15.3    317.9    0.91      8.4     14.9    319.3    0.88     16.3     14.4    314.4    0.85     32.1       
 16    15.8   360.4      14.2    348.0    0.90      7.1     13.8    347.4    0.87     13.9     13.5    345.1    0.85     27.4       
 20    16.0   387.3      15.1    375.7    0.94      7.0     14.3    374.8    0.89     13.3     14.4    370.8    0.90     27.1       
 24    16.1   404.8      15.6    393.3    0.97      6.9     15.3    392.2    0.95     13.6     14.4    390.8    0.89     25.8       
 28    15.3   429.0      14.7    414.8    0.96      6.2     13.9    414.3    0.91     11.7     13.9    410.0    0.91     23.8       
 32    14.7   443.9      14.3    430.3    0.97      5.8     14.0    428.4    0.95     11.5     13.8    424.7    0.94     22.8       
 36    14.7   458.1      13.9    444.4    0.95      5.5     13.7    443.8    0.93     10.8     13.8    438.1    0.94     22.0       
 40    14.6   468.0      13.8    454.9    0.95      5.3     13.8    454.1    0.95     10.6     13.4    448.6    0.92     20.9       
 44    14.7   480.6      14.1    468.1    0.96      5.3     13.9    467.9    0.95     10.4     13.5    461.9    0.92     20.5       
 48    16.1   481.3      15.3    469.7    0.95      5.7     15.1    470.2    0.94     11.2     14.8    464.8    0.92     22.3       
 52    15.8   491.9      14.7    478.6    0.93      5.4     15.0    478.7    0.95     10.9     14.8    472.3    0.94     21.9       
 56    14.9   498.2      14.1    484.1    0.95      5.1     14.0    485.7    0.94     10.1     14.0    476.4    0.94     20.5       
 60    15.4   505.4      14.8    492.6    0.96      5.3     14.0    491.9    0.91     10.0     14.1    486.0    0.92     20.3       
 64    16.3   506.2      15.2    495.4    0.93      5.4     15.0    495.3    0.92     10.6     14.9    487.0    0.91     21.4       
 68    15.5   510.9      14.3    497.0    0.92      5.0     14.1    497.3    0.91      9.9     13.7    487.7    0.88     19.7       
 72    15.3   511.6      15.1    499.5    0.99      5.3     14.4    497.3    0.94     10.1     14.3    487.4    0.93     20.5       
 76    15.1   509.6      14.2    502.5    0.94      4.9     13.8    495.0    0.91      9.8     13.6    490.2    0.90     19.4       
 80    14.8   509.4      14.4    503.0    0.97      5.0     13.8    497.2    0.93      9.7     13.3    490.9    0.90     18.9       
 81    14.0   510.5      13.2    503.8    0.94      4.6     14.0    494.3    1.00      9.9     13.6    488.7    0.97     19.4       
 84    16.2   507.5      14.8    496.7    0.91      5.2     14.8    495.2    0.91     10.5     14.2    482.3    0.88     20.7       
 88    14.8   505.5      13.6    500.3    0.92      4.7     13.0    496.1    0.88      9.2     13.6    482.5    0.92     19.7       
 92    15.8   510.8      14.4    497.9    0.91      5.1     13.4    491.9    0.85      9.6     13.9    477.5    0.88     20.4       
 96    17.1   511.4      15.4    483.3    0.90      5.6     15.2    489.1    0.89     10.9     15.2    483.1    0.89     22.1       
100    16.5   505.7      14.8    473.5    0.90      5.5     16.0    488.1    0.97     11.5     17.6    476.9    1.07     25.9       
104    16.9   491.1      15.6    482.3    0.92      5.6     15.1    480.7    0.89     11.0     16.6    473.4    0.98     24.5       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN   17.1   268.3      15.6    260.7    0.91     10.9     15.4    261.6    0.90     21.4     15.0    258.6    0.87     42.2       
SD(D)   0.5               0.5             0.01      2.7      0.5             0.01      5.6      0.8             0.02     10.7       
CV(E)   3.0               2.9             1.0      25.1      3.4             1.6      26.3      5.1             2.4      25.3       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN   15.4   440.5      14.6    427.8    0.95      6.0     14.3    427.2    0.93     11.8     14.0    422.7    0.91     23.5       
SD(D)   0.7               0.6             0.02      0.7      0.6             0.03      1.3      0.5             0.03      2.5       
CV(E)   4.3               4.2             2.3      12.3      4.3             3.0      11.1      3.7             2.8      10.6       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN   15.6   506.7      14.6    493.7    0.93      5.2     14.3    492.5    0.92     10.2     14.5    483.6    0.93     21.0       
SD(D)   0.9               0.7             0.03      0.3      0.8             0.04      0.6      1.3             0.05      2.0       
CV(E)   5.6               4.7             2.9       5.9      5.5             4.1       6.0      8.7             5.6       9.5       
==================================================================================================================================  
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
              DIAGNOSTIC TRAILER REPORT                                                                                             
              WATER AND COMPOUND CONSUMPTION BY MALE RATS IN THE                                                                    
              CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                                     
=========================================================================================================                           
           0 MG/L                  175 MG/L                 350 MG/L                 700 MG/L                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM                              
WEEK WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS                             
==========================================================================================================                          
  B              105.5  50                105.6  50                103.6  50                105.2  50                               
  1              105.5  50                105.6  50                103.6  50                105.2  50                               
  4  16.7  8223  200.6  50    15.4  8283  194.8  50    15.2  8161  193.6  50    14.7  8273  192.7  50                               
  8  17.7  8025  277.6  50    16.1  8227  269.3  50    15.9  8230  272.0  50    15.8  7941  268.7  50                               
 12  16.9  7914  326.5  50    15.3  8161  317.9  50    14.9  8052  319.3  50    14.4  8213  314.4  50                               
 16  15.8  8374  360.4  50    14.2  8302  348.0  50    13.8  8078  347.4  50    13.5  8296  345.1  50                               
 20  16.0  8376  387.3  50    15.1  8339  375.7  50    14.3  8333  374.8  50    14.4  8323  370.8  50                               
 24  16.1  8084  404.8  50    15.6  7601  393.3  50    15.3  7939  392.2  50    14.4  7884  390.8  50                               
 28  15.3  7910  429.0  50    14.7  7370  414.8  50    13.9  7907  414.3  50    13.9  7548  410.0  50                               
 32  14.7  8338  443.9  50    14.3  8328  430.3  50    14.0  7076  428.4  50    13.8  8328  424.7  50                               
 36  14.7  8267  458.1  50    13.9  8265  444.4  50    13.7  8169  443.8  50    13.8  8166  438.1  50                               
 40  14.6  8238  468.0  50    13.8  7949  454.9  50    13.8  8017  454.1  50    13.4  8166  448.6  50                               
 44  14.7  8036  480.6  50    14.1  8310  468.1  50    13.9  8383  467.9  50    13.5  8383  461.9  50                               
 48  16.1  8389  481.3  50    15.3  8241  469.7  50    15.1  8471  470.2  50    14.8  8506  464.8  50                               
 52  15.8  8208  491.9  49    14.7  7844  478.6  50    15.0  8084  478.7  50    14.8  7579  472.3  50                               
 56  14.9  7860  498.2  49    14.1  8302  484.1  50    14.0  8144  485.7  50    14.0  8336  476.4  50                               
 60  15.4  7937  505.4  48    14.8  7895  492.6  49    14.0  8103  491.9  50    14.1  8021  486.0  50                               
 64  16.3  7739  506.2  48    15.2  7632  495.4  49    15.0  7904  495.3  49    14.9  7782  487.0  50                               
 68  15.5  7543  510.9  47    14.3  7804  497.0  49    14.1  7890  497.3  49    13.7  8178  487.7  49                               
 72  15.3  7491  511.6  46    15.1  7406  499.5  49    14.4  6983  497.3  49    14.3  7350  487.4  47                               
 76  15.1  7127  509.6  46    14.2  7004  502.5  47    13.8  7673  495.0  49    13.6  6396  490.2  45                               
 80  14.8  4157  509.4  44    14.4  4258  503.0  46    13.8  4448  497.2  47    13.3  3742  490.9  47                               
 81  14.0  6790  510.5  44    13.2  7193  503.8  45    14.0  7481  494.3  47    13.6  7418  488.7  46                               
 84  16.2  6768  507.5  44    14.8  6484  496.7  44    14.8  7230  495.2  46    14.2  7483  482.3  46                               
 88  14.8  7156  505.5  44    13.6  7103  500.3  44    13.0  7211  496.1  45    13.6  7346  482.5  45                               
 92  15.8  6357  510.8  41    14.4  6700  497.9  42    13.4  6945  491.9  43    13.9  6104  477.5  39                               
 96  17.1  5845  511.4  38    15.4  6105  483.3  39    15.2  6321  489.1  40    15.2  5755  483.1  35                               
100  16.5  6065  505.7  36    14.8  5551  473.5  35    16.0  5844  488.1  36    17.6  4952  476.9  32                               
104  16.9  4712  491.1  31    15.6  4480  482.3  28    15.1  4823  480.7  31    16.6  4237  473.4  27                               
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13          227.6                    221.9                    222.1                    220.3                                   
14 TO 52         440.5                    427.8                    427.2                    422.7                                   
 > 52            506.7                    493.7                    492.5                    483.6                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.