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TDMS Study 93021-03 Pathology Tables

NTP Experiment-Test: 93021-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                              DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97
Route: SKIN APPLICATION                                                                                           Time: 10:15:45

                                                       13 WEEK SUBCHRONIC




       Facility:  Microbiological Associates

       Chemical CAS #:  538-75-0

       Lock Date:  05/17/95

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 93021-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                              DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97  
Route: SKIN APPLICATION                                                                                           Time: 10:15:45  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0            0.75         1.5          3.0          6.0          12.0            
                                                   MG/KG        MG/KG        MG/KG        MG/KG        MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                                                                                 10           
  Survivors                                                                                                                         
    Accidently Killed                                  2                                                                            
    Terminal Sacrifice                                 8           10           10           10           10                        

  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)                                   (1)          (10)         (10)         
      Hepatodiaphragmatic Nodule                                                              1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)                                                (10)         (10)         
      Cardiomyopathy                                   1 (10%)                                             1 (10%)      4 (40%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Pituitary Gland                                    (10)                                                (10)         (9)          
      Pars Distalis, Cyst                                                                                               1 (11%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (10)                                                (9)          (10)         
      Inflammation, Chronic Active, Focal                                                                  1 (11%)                  
   Uterus                                             (10)                      (1)          (1)          (10)         (10)         
      Hydrometra                                                                 1 (100%)     1 (100%)     2 (20%)                  
      Bilateral, Hydrometra                            1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 93021-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                              DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97  
Route: SKIN APPLICATION                                                                                           Time: 10:15:45  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0            0.75         1.5          3.0          6.0          12.0            
                                                   MG/KG        MG/KG        MG/KG        MG/KG        MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (10)         (10)         (10)         (10)         (10)         (10)         
      Hyperplasia, Diffuse                                                                                 1 (10%)      9 (90%)     
      Hyperplasia, Focal, Histiocytic                  4 (40%)                   4 (40%)      2 (20%)      1 (10%)                  
   Lymph Node                                                                                             (1)                       
      Hyperplasia, Diffuse, Lymphoid                                                                       1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Control, Inflammation, Chronic Active                                                   1 (10%)      1 (10%)      2 (20%)     
      Dermis, Skin, Site of Application, Edema,                                                                                     
           Focal                                                                                                        1 (10%)     
      Dermis, Skin, Site of Application,                                                                                            
          Inflammation, Chronic Active                                                                                  1 (10%)     
      Epidermis, Control, Hyperplasia                               1 (10%)      1 (10%)                   1 (10%)      1 (10%)     
      Epidermis, Control, Necrosis                                                                                      1 (10%)     
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia                                               3 (30%)      7 (70%)      7 (70%)     10 (100%)    10 (100%)    
      Epidermis, Skin, Site of Application,                                                                                         
          Necrosis                                                                                         1 (10%)      3 (30%)     
      Epidermis, Skin, Site of Application,                                                                                         
          Necrosis, Focal                                                                                               1 (10%)     
      Sebaceous Gland, Skin, Site of Application,                                                                                   
           Hyperplasia                                              1 (10%)                                5 (50%)      7 (70%)     
      Skin, Site of Application, Inflammation,                                                                                      
           Acute                                                                                           1 (10%)                  
      Skin, Site of Application, Inflammation,                                                                                      
           Chronic Active                                                        4 (40%)      4 (40%)      9 (90%)      9 (90%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 93021-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                              DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97  
Route: SKIN APPLICATION                                                                                           Time: 10:15:45  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0            0.75         1.5          3.0          6.0          12.0            
                                                   MG/KG        MG/KG        MG/KG        MG/KG        MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (9)          (10)         (9)          (10)         (10)         
      Inflammation, Chronic Active, Focal              8 (80%)      9 (100%)     6 (60%)      7 (78%)      7 (70%)      2 (20%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)                                                (10)         (10)         
      Nephropathy                                      2 (20%)                                             1 (10%)      4 (40%)     
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 93021-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                              DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97  
Route: SKIN APPLICATION                                                                                           Time: 10:15:45  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0            0.75         1.5          3.0          6.0          12.0            
                                                   MG/KG        MG/KG        MG/KG        MG/KG        MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Natural Death                                                                                                       2           
    Moribund Sacrifice                                                                                                  8           
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10                        

  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)                                                (10)         (10)         
      Hepatodiaphragmatic Nodule                       1 (10%)                                                                      
      Inflammation, Chronic Active                                                                                      1 (10%)     
   Stomach, Forestomach                               (10)                                                (10)         (10)         
      Hyperplasia, Atypical, Focal                                                                         1 (10%)                  
      Inflammation, Acute, Focal                                                                           1 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)                                                (10)         (10)         
      Cardiomyopathy                                   1 (10%)                                             3 (30%)      2 (20%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (10)                                                (10)         (10)         
      Inflammation, Chronic, Focal                     1 (10%)                                             1 (10%)                  
      Inflammation, Chronic Active, Focal              1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 93021-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                              DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97  
Route: SKIN APPLICATION                                                                                           Time: 10:15:45  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0            0.75         1.5          3.0          6.0          12.0            
                                                   MG/KG        MG/KG        MG/KG        MG/KG        MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (10)         (10)         (10)         (10)         (10)         (10)         
      Hyperplasia, Diffuse                                                                                             10 (100%)    
   Spleen                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Depletion Cellular, Diffuse                                                                                       1 (10%)     
      Hematopoietic Cell Proliferation, Focal                       1 (10%)      1 (10%)      1 (10%)      2 (20%)      1 (10%)     
   Thymus                                             (10)                                                (10)         (10)         
      Atrophy                                                                                                           1 (10%)     
      Necrosis, Diffuse                                                                                                 2 (20%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Control, Inflammation, Chronic Active                                                                3 (30%)      2 (20%)     
      Epidermis, Control, Hyperplasia                                                                      5 (50%)      1 (10%)     
      Epidermis, Control, Necrosis                                                                         1 (10%)      1 (10%)     
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia                                               1 (10%)      3 (30%)      9 (90%)     10 (100%)    10 (100%)    
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia, Focal                                        1 (10%)                                                         
      Epidermis, Skin, Site of Application,                                                                                         
          Necrosis                                                                                                      6 (60%)     
      Sebaceous Gland, Skin, Site of Application,                                                                                   
           Hyperplasia                                              1 (10%)      1 (10%)      4 (40%)      7 (70%)      6 (60%)     
      Skin, Site of Application, Inflammation,                                                                                      
           Acute, Diffuse                                                                                               1 (10%)     
      Skin, Site of Application, Inflammation,                                                                                      
           Chronic Active                                           1 (10%)                   1 (10%)      7 (70%)      9 (90%)     
      Skin, Site of Application, Inflammation,                                                                                      
           Granulomatous                                                                                                1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Hemorrhage                                                                                                        1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 93021-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                              DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97  
Route: SKIN APPLICATION                                                                                           Time: 10:15:45  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0            0.75         1.5          3.0          6.0          12.0            
                                                   MG/KG        MG/KG        MG/KG        MG/KG        MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (8)          (10)         (10)         
      Congestion, Diffuse                                                                                               2 (20%)     
      Inflammation, Chronic Active, Focal              8 (80%)      8 (80%)      7 (70%)      7 (88%)      9 (90%)      3 (30%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)                                                (10)         (10)         
      Nephropathy                                      6 (60%)                                             5 (50%)      2 (20%)     
      Renal Tubule, Degeneration, Focal                1 (10%)                                                                      
   Urinary Bladder                                    (10)                                                (10)         (10)         
      Hemorrhage                                                                                                        1 (10%)     
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

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