National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/13666

TDMS Study 96018-03 Pathology Tables

NTP Experiment-Test: 96018-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04
Route: DOSED WATER                                                                                                Time: 09:31:58

                                                         FINAL #2/RATS




       Facility:  Southern Research Institute

       Chemical CAS #:  75-27-4

       Lock Date:  02/19/02

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 96018-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:31:58    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                16           19           14           15                                     
    Natural Death                                      5            2            7            9                                     
    Accidently Killed                                               1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           27           29           26                                     
    Moribund Sacrifice                                 1            1                                                               
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (46)         (49)         (44)         (43)                                   
      Edema                                                                      1 (2%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis, Focal                               4 (8%)       4 (8%)       5 (10%)      2 (4%)                                
      Basophilic Focus                                33 (66%)     25 (50%)     24 (48%)     17 (34%)                               
      Cholangiofibrosis                                1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Clear Cell Focus                                28 (56%)     24 (48%)     19 (38%)     17 (34%)                               
      Congestion                                       2 (4%)       1 (2%)       1 (2%)       4 (8%)                                
      Degeneration, Cystic, Focal                     31 (62%)     24 (48%)     23 (46%)     29 (58%)                               
      Eosinophilic Focus                                            1 (2%)       4 (8%)                                             
      Fibrosis, Focal                                  1 (2%)       1 (2%)       1 (2%)       3 (6%)                                
      Hemorrhage, Focal                                                                       1 (2%)                                
      Hepatodiaphragmatic Nodule                       5 (10%)      5 (10%)     12 (24%)      4 (8%)                                
      Hyperplasia, Focal, Histiocytic                                            1 (2%)                                             
      Hyperplasia, Focal, Regenerative                                                        1 (2%)                                
      Infiltration Cellular, Mixed Cell               30 (60%)     31 (62%)     34 (68%)     34 (68%)                               
      Inflammation, Chronic                           23 (46%)     29 (58%)     33 (66%)     34 (68%)                               
      Mixed Cell Focus                                              3 (6%)      10 (20%)      4 (8%)                                
      Necrosis, Focal                                  2 (4%)                                 1 (2%)                                
      Tension Lipidosis                                                          1 (2%)                                             
      Bile Duct, Hyperplasia                          45 (90%)     49 (98%)     49 (98%)     50 (100%)                              
      Hepatocyte, Fatty Change                        36 (72%)     34 (68%)     36 (72%)     40 (80%)                               
      Hepatocyte, Hyperplasia, Regenerative                                                   1 (2%)                                
      Hepatocyte, Hypertrophy                                       1 (2%)                                                          
      Hepatocyte, Vacuolization Cytoplasmic           11 (22%)     10 (20%)     19 (38%)     18 (36%)                               
      Hepatocyte, Centrilobular, Necrosis              1 (2%)       1 (2%)       1 (2%)       4 (8%)                                
      Serosa, Bile Duct, Inflammation, Chronic,                                                                                     
         Focal                                                                                1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96018-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:31:58    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Mesentery                                          (15)         (13)         (14)         (15)                                   
      Hemorrhage, Focal                                                                       1 (7%)                                
      Inflammation, Chronic                            1 (7%)                    1 (7%)                                             
      Fat, Necrosis, Focal                             8 (53%)      4 (31%)      9 (64%)      7 (47%)                               
   Pancreas                                           (49)         (50)         (50)         (49)                                   
      Cyst                                                                       1 (2%)                                             
      Hyperplasia, Focal, Histiocytic                                                         1 (2%)                                
      Acinus, Atrophy, Focal                          31 (63%)     20 (40%)     23 (46%)     21 (43%)                               
      Acinus, Hyperplasia, Focal                       1 (2%)                                                                       
      Duct, Cyst                                       1 (2%)                                                                       
      Duct, Cyst, Focal, Multiple                     16 (33%)     14 (28%)     17 (34%)     11 (22%)                               
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Edema                                            2 (4%)       2 (4%)       3 (6%)       4 (8%)                                
      Erosion                                                                                 1 (2%)                                
      Inflammation, Chronic, Diffuse                                             1 (2%)                                             
      Inflammation, Diffuse                                                      2 (4%)                                             
      Inflammation, Focal                              1 (2%)       2 (4%)       2 (4%)       1 (2%)                                
      Ulcer                                            1 (2%)       4 (8%)       4 (8%)       4 (8%)                                
      Epithelium, Hyperplasia                          2 (4%)       5 (10%)      4 (8%)       6 (12%)                               
   Stomach, Glandular                                 (49)         (50)         (50)         (50)                                   
      Atypia Cellular, Focal                                                     1 (2%)                                             
      Edema                                                         1 (2%)                                                          
      Erosion                                          2 (4%)       4 (8%)       1 (2%)       4 (8%)                                
      Fibrosis, Focal                                                                         1 (2%)                                
      Infarct                                                       1 (2%)                                                          
      Inflammation, Focal                                           1 (2%)                                                          
      Pigmentation, Focal                                           1 (2%)                    1 (2%)                                
      Ulcer                                            1 (2%)                                                                       
      Artery, Inflammation, Chronic                                 1 (2%)                                                          
      Epithelium, Hyperplasia                                                                 2 (4%)                                
      Epithelium, Hyperplasia, Focal                   1 (2%)                                                                       
      Glands, Ectasia, Focal                                        1 (2%)                    1 (2%)                                
      Glands, Necrosis, Focal                                       1 (2%)                                                          
   Tongue                                             (1)          (1)          (1)          (1)                                    
      Infiltration Cellular, Focal, Mixed Cell                      1 (100%)                                                        
      Epithelium, Hyperplasia, Focal                                             1 (100%)                                           
   Tooth                                                           (1)                                                              
      Epithelium Alveolus, Hyperplasia                              1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96018-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:31:58    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Cardiomyopathy                                  16 (32%)     18 (36%)     21 (42%)     14 (28%)                               
      Fibrosis, Focal                                                            1 (2%)                                             
      Infiltration Cellular, Mixed Cell                1 (2%)                                                                       
      Thrombosis                                                    2 (4%)                    2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (49)                                   
      Accessory Adrenal Cortical Nodule               14 (28%)      8 (16%)      8 (16%)     14 (29%)                               
      Angiectasis                                                                1 (2%)                                             
      Cytoplasmic Alteration, Focal                    1 (2%)       3 (6%)       3 (6%)       2 (4%)                                
      Infiltration Cellular, Mixed Cell                             1 (2%)                                                          
      Necrosis, Focal                                  2 (4%)                    1 (2%)       1 (2%)                                
      Vacuolization Cytoplasmic, Focal                 9 (18%)      5 (10%)      8 (16%)     12 (24%)                               
   Adrenal Medulla                                    (50)         (50)         (50)         (49)                                   
      Cytoplasmic Alteration, Focal                                                           1 (2%)                                
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia                                                                             1 (2%)                                
      Hyperplasia, Focal                              11 (22%)     17 (34%)     15 (30%)     13 (27%)                               
      Necrosis, Focal                                  1 (2%)                    1 (2%)                                             
      Thrombosis                                                                              1 (2%)                                
      Bilateral, Hyperplasia, Focal                                 1 (2%)                                                          
   Islets, Pancreatic                                 (49)         (50)         (50)         (49)                                   
      Hyperplasia                                                   1 (2%)       1 (2%)       1 (2%)                                
      Hyperplasia, Focal                               2 (4%)                                                                       
   Parathyroid Gland                                  (48)         (49)         (50)         (50)                                   
      Cyst                                                                                    1 (2%)                                
      Hyperplasia, Focal                                                         1 (2%)                                             
   Pituitary Gland                                    (49)         (50)         (50)         (48)                                   
      Angiectasis                                      2 (4%)       2 (4%)                    1 (2%)                                
      Craniopharyngeal Duct, Cyst                      1 (2%)                                                                       
      Pars Distalis, Cyst                              2 (4%)       2 (4%)       2 (4%)       2 (4%)                                
      Pars Distalis, Cytoplasmic Alteration, Focal     7 (14%)      6 (12%)      1 (2%)       6 (13%)                               
      Pars Distalis, Degeneration, Cystic, Focal       1 (2%)                                 3 (6%)                                
      Pars Distalis, Hemorrhage, Focal                 3 (6%)       5 (10%)      1 (2%)       3 (6%)                                
      Pars Distalis, Hyperplasia, Focal                3 (6%)       2 (4%)       2 (4%)       7 (15%)                               
      Pars Distalis, Necrosis, Focal                   1 (2%)                                                                       
      Pars Intermedia, Cyst                                         1 (2%)                                                          
      Rathke's Cleft, Cyst                             2 (4%)       2 (4%)                                                          
      Rathke's Cleft, Hemorrhage                                                 1 (2%)                                             
   Thyroid Gland                                      (46)         (48)         (44)         (42)                                   
      Hemorrhage                                                                 1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96018-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:31:58    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      C-Cell, Hyperplasia                             44 (96%)     46 (96%)     40 (91%)     41 (98%)                               
      Follicle, Degeneration, Cystic, Focal                         2 (4%)                                                          
      Follicular Cell, Hyperplasia                                                            2 (5%)                                
      Follicular Cell, Hyperplasia, Cystic, Focal      5 (11%)      4 (8%)       4 (9%)       3 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (50)         (50)         (50)                                   
      Inflammation, Chronic                            1 (2%)                                                                       
   Preputial Gland                                    (50)         (50)         (50)         (49)                                   
      Degeneration, Cystic                             1 (2%)                    1 (2%)       2 (4%)                                
      Fibrosis                                                                                1 (2%)                                
      Hyperplasia, Cystic                              2 (4%)       1 (2%)       1 (2%)       2 (4%)                                
      Inflammation, Chronic                           32 (64%)     30 (60%)     31 (62%)     37 (76%)                               
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic                           29 (58%)     33 (66%)     35 (70%)     38 (76%)                               
      Mineralization, Focal                                                                   2 (4%)                                
      Epithelium, Hyperplasia, Focal                  25 (50%)     21 (42%)     24 (48%)     23 (46%)                               
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Dilatation                                                                 1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
   Testes                                             (50)         (50)         (50)         (50)                                   
      Atrophy                                          5 (10%)      8 (16%)      8 (16%)      8 (16%)                               
      Necrosis                                         1 (2%)                                                                       
      Artery, Thrombosis, Focal                        1 (2%)                                                                       
      Bilateral, Atrophy                               1 (2%)                    1 (2%)       1 (2%)                                
      Bilateral, Interstitial Cell, Hyperplasia,                                                                                    
         Focal                                                      1 (2%)                                                          
      Interstitial Cell, Hyperplasia                                             1 (2%)                                             
      Interstitial Cell, Hyperplasia, Focal            3 (6%)       1 (2%)       3 (6%)       3 (6%)                                
      Tunic, Inflammation, Chronic                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (45)         (49)         (49)                                   
      Hyperplasia                                      2 (4%)       2 (4%)       5 (10%)      2 (4%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96018-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:31:58    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Focal, Histiocytic                               1 (2%)                    1 (2%)                                
      Hyperplasia, Histiocytic                                      1 (2%)                                                          
      Myeloid Cell, Hyperplasia                        2 (4%)                    3 (6%)       1 (2%)                                
      Myeloid Cell, Erythroid Cell, Hyperplasia        1 (2%)       5 (11%)                   5 (10%)                               
   Lymph Node                                         (25)         (28)         (26)         (26)                                   
      Bronchial, Hyperplasia, Plasma Cell                           1 (4%)                                                          
      Deep Cervical, Ectasia                                                                  1 (4%)                                
      Mediastinal, Angiectasis                         2 (8%)                                 1 (4%)                                
      Mediastinal, Ectasia                             3 (12%)      1 (4%)       3 (12%)      4 (15%)                               
      Mediastinal, Hemorrhage                                                    1 (4%)       2 (8%)                                
      Mediastinal, Hyperplasia                                      1 (4%)                                                          
      Mediastinal, Hyperplasia, Histiocytic            2 (8%)                    1 (4%)       2 (8%)                                
      Mediastinal, Hyperplasia, Lymphoid               1 (4%)       1 (4%)       1 (4%)                                             
      Mediastinal, Hyperplasia, Plasma Cell            1 (4%)       3 (11%)      6 (23%)      1 (4%)                                
      Mediastinal, Inflammation                        1 (4%)                                                                       
      Pancreatic, Angiectasis                                                                 1 (4%)                                
      Pancreatic, Ectasia                              3 (12%)      5 (18%)      3 (12%)      5 (19%)                               
      Pancreatic, Hemorrhage                           1 (4%)                    2 (8%)       1 (4%)                                
      Pancreatic, Hyperplasia, Histiocytic             3 (12%)      7 (25%)                   5 (19%)                               
      Pancreatic, Pigmentation                         1 (4%)                    1 (4%)       1 (4%)                                
   Lymph Node, Mesenteric                             (50)         (49)         (50)         (50)                                   
      Ectasia                                                       1 (2%)                                                          
      Hemorrhage                                       2 (4%)                                 1 (2%)                                
      Hyperplasia, Histiocytic                                      2 (4%)                    1 (2%)                                
   Spleen                                             (48)         (49)         (49)         (50)                                   
      Accessory Spleen                                 1 (2%)                    1 (2%)       1 (2%)                                
      Angiectasis, Focal                               1 (2%)       2 (4%)                                                          
      Congestion                                                    1 (2%)       1 (2%)                                             
      Fibrosis, Focal                                  4 (8%)       3 (6%)       1 (2%)       1 (2%)                                
      Hematopoietic Cell Proliferation                 6 (13%)      7 (14%)      5 (10%)     11 (22%)                               
      Hemorrhage                                                                              2 (4%)                                
      Hemorrhage, Chronic                              1 (2%)                                                                       
      Hyperplasia, Focal, Histiocytic                               1 (2%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Infarct                                          2 (4%)       1 (2%)       1 (2%)                                             
      Necrosis, Focal                                                                         1 (2%)                                
      Pigmentation                                                               1 (2%)                                             
      Artery, Thrombosis                               1 (2%)                                                                       
      Capsule, Fibrosis, Focal                         1 (2%)                                                                       
   Thymus                                             (48)         (48)         (50)         (47)                                   
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96018-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:31:58    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (44)         (45)         (47)         (42)                                   
      Atypia Cellular, Focal                                                     1 (2%)                                             
      Dilatation                                       8 (18%)     18 (40%)     16 (34%)     12 (29%)                               
      Ectasia                                                                    1 (2%)       1 (2%)                                
      Fibrosis                                                      1 (2%)                                                          
      Fibrosis, Focal                                                                         1 (2%)                                
      Hyperplasia                                      2 (5%)       3 (7%)       2 (4%)       1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                                                               2 (4%)                                
      Hyperkeratosis, Focal                                                                   1 (2%)                                
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Mineralization, Focal                                                      1 (2%)                                             
      Subcutaneous Tissue, Angiectasis, Focal          1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Cyst, Chronic               1 (2%)                                                                       
      Subcutaneous Tissue, Cyst Epithelial                                                                                          
        Inclusion                                                                1 (2%)                                             
      Subcutaneous Tissue, Edema                       1 (2%)                                                                       
      Subcutaneous Tissue, Hemorrhage, Focal           1 (2%)                    1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Inflammation, Focal,                                                                                     
         Granulomatous                                                           1 (2%)                                             
      Subcutaneous Tissue, Metaplasia, Focal,                                                                                       
        Osseous                                        1 (2%)                                                                       
      Subcutaneous Tissue, Necrosis, Fatty, Focal                                             1 (2%)                                
      Subcutaneous Tissue, Epidermis, Hyperplasia,                                                                                  
         Focal                                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Hyperostosis                                                  1 (2%)                                                          
   Skeletal Muscle                                    (3)                                    (2)                                    
      Hemorrhage, Focal                                                                       1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Compression, Focal                               6 (12%)      8 (16%)     14 (28%)     14 (28%)                               
      Hemorrhage, Focal                                2 (4%)       4 (8%)       1 (2%)       3 (6%)                                
      Hydrocephalus                                                              2 (4%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 96018-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:31:58    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - CONT                                                                                                               
      Necrosis, Focal                                  1 (2%)       2 (4%)                                                          
      Cerebellum, Hemorrhage, Focal                                              1 (2%)                                             
      Cerebrum, Ventricle, Hydrocephalus                            1 (2%)                                                          
      Pineal Gland, Vacuolization Cytoplasmic                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                       4 (8%)       1 (2%)       3 (6%)       5 (10%)                               
      Fibrosis, Focal                                                                         1 (2%)                                
      Hemorrhage                                       1 (2%)       1 (2%)                    1 (2%)                                
      Hemorrhage, Focal                                3 (6%)       1 (2%)       2 (4%)       2 (4%)                                
      Hyperplasia, Focal, Histiocytic                  1 (2%)       1 (2%)                                                          
      Hyperplasia, Histiocytic                         1 (2%)       1 (2%)                    2 (4%)                                
      Infiltration Cellular, Mixed Cell                2 (4%)                                 1 (2%)                                
      Inflammation, Chronic, Focal                                  2 (4%)       3 (6%)       2 (4%)                                
      Metaplasia, Squamous                                          1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia, Focal          7 (14%)      6 (12%)      9 (18%)      5 (10%)                               
      Interstitium, Edema                              1 (2%)                                                                       
      Mediastinum, Angiectasis, Focal                                                         1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation, Suppurative                        2 (4%)       3 (6%)       3 (6%)       3 (6%)                                
      Nasolacrimal Duct, Inflammation                                            3 (6%)       1 (2%)                                
      Olfactory Epithelium, Mineralization, Focal                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (49)         (49)         (48)         (47)                                   
      Cataract                                         2 (4%)       1 (2%)       7 (15%)                                            
      Inflammation, Chronic                                                      1 (2%)                                             
      Retina, Degeneration                             3 (6%)       1 (2%)       8 (17%)      1 (2%)                                
   Harderian Gland                                    (50)         (50)         (50)         (48)                                   
      Hyperplasia, Focal, Histiocytic                                            1 (2%)                                             
      Hyperplasia, Focal, Lymphoid                                               1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Inflammation, Chronic, Focal                     1 (2%)                    1 (2%)                                             
      Epithelium, Hyperplasia, Focal                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 96018-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:31:58    
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         FISCHER 344 RATS MALE                     0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)         (49)                                   
      Cyst                                                                                    1 (2%)                                
      Infarct                                                       3 (6%)       1 (2%)                                             
      Metaplasia, Focal, Osseous                                                 1 (2%)                                             
      Nephropathy                                     49 (100%)    50 (100%)    49 (98%)     46 (94%)                               
      Artery, Thrombosis                                            1 (2%)                                                          
      Cortex, Necrosis, Focal                                                                 1 (2%)                                
      Pelvis, Dilatation                                                         1 (2%)                                             
      Pelvis, Transitional Epithelium, Hyperplasia                                            1 (2%)                                
      Renal Tubule, Hyperplasia, Atypical, Focal                                              1 (2%)                                
      Renal Tubule, Pigmentation                      10 (20%)     13 (26%)      7 (14%)      3 (6%)                                
   Urinary Bladder                                    (49)         (50)         (50)         (49)                                   
      Hemorrhage                                                    1 (2%)       1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.