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TDMS Study 96018-03 Pathology Tables

NTP Experiment-Test: 96018-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 04/15/03
Route: DOSED WATER                                                                                                Time: 15:27:34

                                                          FINAL#1/RATS




       Facility:  Southern Research Institute

       Chemical CAS #:  75-27-4

       Lock Date:  02/19/02

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 96018-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 04/15/03  
Route: DOSED WATER                                                                                                Time: 15:27:34  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
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DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                16           19           14           15                                     
    Natural Death                                      5            2            7            9                                     
    Accidently Killed                                               1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           27           29           26                                     
    Moribund Sacrifice                                 1            1                                                               
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
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 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (49)         (46)         (44)                                   
   Intestine Large, Rectum                            (49)         (49)         (46)         (46)                                   
      Polyp Adenomatous                                                          1 (2%)                                             
   Intestine Large, Cecum                             (46)         (49)         (44)         (43)                                   
   Intestine Small, Duodenum                          (48)         (50)         (48)         (45)                                   
   Intestine Small, Jejunum                           (47)         (49)         (46)         (44)                                   
   Intestine Small, Ileum                             (46)         (49)         (45)         (42)                                   
   Liver                                              (49)         (50)         (50)         (50)                                   
      Hepatocellular Adenoma                           1 (2%)       2 (4%)       3 (6%)                                             
   Mesentery                                          (15)         (13)         (14)         (15)                                   
   Oral Mucosa                                                     (2)          (1)                                                 
      Squamous Cell Papilloma                                       1 (50%)                                                         
      Gingival, Squamous Cell Carcinoma                                          1 (100%)                                           
   Pancreas                                           (49)         (50)         (50)         (49)                                   
      Acinus, Adenoma                                  3 (6%)       1 (2%)       3 (6%)       4 (8%)                                
      Acinus, Adenoma, Multiple                                                  1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (50)         (49)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Papilloma                                                    1 (2%)                                             
   Stomach, Glandular                                 (49)         (50)         (50)         (50)                                   
      Fibrosarcoma                                                                            1 (2%)                                
   Tongue                                             (1)          (1)          (1)          (1)                                    
      Squamous Cell Papilloma                          1 (100%)                               1 (100%)                              
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NTP Experiment-Test: 96018-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 04/15/03  
Route: DOSED WATER                                                                                                Time: 15:27:34  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
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 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Schwannoma Benign                                1 (2%)                    1 (2%)                                             
      Myocardium, Pericardium, Epicardium,                                                                                          
          Mesothelioma Malignant                       1 (2%)                                                                       
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 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (49)                                   
      Adenoma                                                                    1 (2%)                                             
   Adrenal Medulla                                    (50)         (50)         (50)         (49)                                   
      Pheochromocytoma Malignant                       1 (2%)                    1 (2%)       2 (4%)                                
      Pheochromocytoma Complex                         2 (4%)       1 (2%)                                                          
      Pheochromocytoma Benign                          5 (10%)      8 (16%)     10 (20%)      8 (16%)                               
      Bilateral, Pheochromocytoma Benign               3 (6%)       1 (2%)       2 (4%)                                             
   Islets, Pancreatic                                 (49)         (50)         (50)         (49)                                   
      Adenoma                                          3 (6%)       1 (2%)       5 (10%)      3 (6%)                                
      Carcinoma                                                     1 (2%)       1 (2%)       1 (2%)                                
   Pituitary Gland                                    (49)         (50)         (50)         (48)                                   
      Pars Distalis, Adenoma                          22 (45%)     29 (58%)     28 (56%)     26 (54%)                               
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (46)         (48)         (44)         (42)                                   
      Bilateral, C-Cell, Adenoma                                                 1 (2%)                                             
      C-Cell, Adenoma                                  8 (17%)      6 (13%)      9 (20%)      7 (17%)                               
      C-Cell, Carcinoma                                1 (2%)       1 (2%)       1 (2%)       4 (10%)                               
      Follicular Cell, Adenoma                                                   1 (2%)                                             
      Follicular Cell, Carcinoma                                    2 (4%)                                                          
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 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (2)          (2)          (2)          (1)                                    
   Tissue NOS                                         (3)          (4)          (2)          (4)                                    
      Schwannoma Malignant                                                                    1 (25%)                               
      Abdominal, Schwannoma Malignant                               1 (25%)                                                         
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NTP Experiment-Test: 96018-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 04/15/03  
Route: DOSED WATER                                                                                                Time: 15:27:34  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
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 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (50)         (50)         (50)                                   
   Preputial Gland                                    (50)         (50)         (50)         (49)                                   
      Adenoma                                          2 (4%)       2 (4%)       3 (6%)                                             
      Carcinoma                                        1 (2%)       3 (6%)                    1 (2%)                                
   Prostate                                           (50)         (50)         (50)         (50)                                   
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
   Testes                                             (50)         (50)         (50)         (50)                                   
      Bilateral, Interstitial Cell, Adenoma           41 (82%)     40 (80%)     40 (80%)     39 (78%)                               
      Interstitial Cell, Adenoma                       4 (8%)       7 (14%)      1 (2%)       8 (16%)                               
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 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (45)         (49)         (49)                                   
   Lymph Node                                         (25)         (28)         (26)         (26)                                   
      Mediastinal, C-Cell, Carcinoma, Metastatic,                                                                                   
           Thyroid Gland                                            1 (4%)                                                          
   Lymph Node, Mandibular                                          (3)          (1)                                                 
   Lymph Node, Mesenteric                             (50)         (49)         (50)         (50)                                   
   Spleen                                             (48)         (49)         (49)         (50)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
   Thymus                                             (48)         (48)         (50)         (47)                                   
      Thymoma Benign                                                1 (2%)                                                          
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 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (44)         (45)         (47)         (42)                                   
      Adenoma                                          1 (2%)                                 1 (2%)                                
      Fibroadenoma                                     1 (2%)       3 (7%)       2 (4%)       2 (5%)                                
      Fibroadenoma, Multiple                                        1 (2%)                                                          
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basal Cell Adenoma                                                                      1 (2%)                                
      Basal Cell Carcinoma                             1 (2%)                                                                       
      Fibroma                                                                    2 (4%)                                             
      Keratoacanthoma                                  3 (6%)       1 (2%)       2 (4%)       3 (6%)                                
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Squamous Cell Papilloma                                                                 1 (2%)                                
      Subcutaneous Tissue, Basal Cell Adenoma          1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     6 (12%)      8 (16%)      6 (12%)      6 (12%)                               
      Subcutaneous Tissue, Fibroma, Multiple                                     2 (4%)                                             
      Subcutaneous Tissue, Fibrosarcoma                                                       1 (2%)                                
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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NTP Experiment-Test: 96018-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 04/15/03  
Route: DOSED WATER                                                                                                Time: 15:27:34  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
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INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Hemangioma                                                         1 (2%)                                
      Subcutaneous Tissue, Lipoma                                                1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                     1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Schwannoma Malignant                                  1 (2%)                                             
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 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Chordoma                                                                   1 (2%)                                             
      Cranium, Schwannoma Malignant, Metastatic,                                                                                    
           Brain                                                                 1 (2%)                                             
      Turbinate, Sarcoma                                                                      1 (2%)                                
   Skeletal Muscle                                    (3)                                    (2)                                    
      Fibrosarcoma                                     1 (33%)                                                                      
      Sarcoma                                          1 (33%)                                                                      
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 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Astrocytoma Malignant                            1 (2%)       1 (2%)                                                          
      Granular Cell Tumor Malignant                                                           1 (2%)                                
      Oligodendroglioma Benign                         1 (2%)                                                                       
      Cerebrum, Schwannoma Malignant, Metastatic,                                                                                   
           Skin                                                                  1 (2%)                                             
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 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                                  1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                    2 (4%)                                             
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
      Neural Crest Tumor, Metastatic, Ear              1 (2%)                                                                       
      Sarcoma, Metastatic, Skeletal Muscle             1 (2%)                                                                       
      C-Cell, Carcinoma, Metastatic, Thyroid Gland                  1 (2%)       1 (2%)       1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Sarcoma                                          1 (2%)                                                                       
   Pleura                                             (1)                                                                           
   Trachea                                            (50)         (50)         (50)         (50)                                   
      C-Cell, Carcinoma, Metastatic, Thyroid Gland                                            1 (2%)                                
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                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 04/15/03  
Route: DOSED WATER                                                                                                Time: 15:27:34  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
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 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                       (1)                                                 
      Pinna, Neural Crest Tumor                        1 (100%)                  1 (100%)                                           
   Eye                                                (49)         (49)         (48)         (47)                                   
      Schwannoma Malignant, Metastatic, Brain                                    1 (2%)                                             
   Harderian Gland                                    (50)         (50)         (50)         (48)                                   
      Adenoma                                          1 (2%)                    1 (2%)                                             
   Zymbal's Gland                                     (3)                       (1)          (2)                                    
      Adenoma                                                                    1 (100%)                                           
      Carcinoma                                        1 (33%)                                1 (50%)                               
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)         (49)                                   
   Urinary Bladder                                    (49)         (50)         (50)         (49)                                   
      Transitional Epithelium, Papilloma                                         1 (2%)                                             
                                                                                                                                    
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 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                            16 (32%)     18 (36%)     16 (32%)     15 (30%)                               
      Lymphoma Malignant                                                         1 (2%)                                             
      Mesothelioma Malignant                           3 (6%)       3 (6%)       3 (6%)       2 (4%)                                
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     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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NTP Experiment-Test: 96018-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 04/15/03  
Route: DOSED WATER                                                                                                Time: 15:27:34  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
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TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          50          50          49                                       
     Total Primary Neoplasms                          142         146         159         143                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 49          49          50          49                                       
     Total Benign Neoplasms                           108         114         130         111                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              28          27          27          27                                       
     Total Malignant Neoplasms                         33          32          28          32                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           3           2           1                                       
     Total Metastatic Neoplasm                          2          10           4           2                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                       1                                                   
     Total Uncertain Neoplasms                          1                       1                                                   
                                                                                                                                    
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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