National Toxicology Program

National Toxicology Program
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TDMS Study 96018-03 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst               WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                 DATE: 04/15/03       
EXPERIMENT: 96018 TEST: 03                                                                                     TIME: 15:28:34       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: C96018       
PATHOLOGIST: FARNELL, DANIEL R.                                                                                CAS: 75-27-4         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                            FINAL#1/RATS                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst               WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                 DATE: 04/15/03       
EXPERIMENT: 96018 TEST: 03                                                                                     TIME: 15:28:34       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: C96018       
PATHOLOGIST: FARNELL, DANIEL R.                                                                                CAS: 75-27-4         
Rats(FISCHER 344)                                                                                                                   
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Brain                                                                              
                                                 Clitoral/Preputial Gland                                                           
                                                 Heart                                                                              
                                                 Islets, Pancreatic                                                                 
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Nose                                                                               
                                                 Pancreas                                                                           
                                                 Pituitary Gland                                                                    
                                                 Spleen                                                                             
                                                 Testes                                                                             
                                                 Thymus                                                                             
                                                 Thyroid Gland                                                                      
                                                 Urinary Bladder                                                                    
                                                                                                                                   
       Date:  04/15/03                           EXPERIMENT: 96018 TEST: 03                                            Page 1       
Statistical Analysis of Primary Tumors in Rats(FISCHER 344)        -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Benign                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  8/50 (16%)               9/50 (18%)               12/50 (24%)              8/49 (16%)      | 
|POLY-3 RATE (b)    |                  8/42.82                  9/43.30                  12/45.17                 8/42.20         | 
|POLY-3 PERCENT (g) |                  18.7%                    20.8%                    26.6%                    19.0%           | 
|TERMINAL (d)       |                  7/29 (24%)               6/28 (21%)               5/29 (17%)               5/26 (19%)      | 
|FIRST INCIDENCE    |                  722                      683                      649                      693             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.439                  P=0.456                  P=0.240                  P=0.511         | 
|POLY 3             |                  P=0.524                  P=0.510                  P=0.265                  P=0.597         | 
|POLY 1.5           |                  P=0.526                  P=0.510                  P=0.251                  P=0.598         | 
|POLY 6             |                  P=0.511                  P=0.504                  P=0.278                  P=0.585         | 
|LOGISTIC REGRESSION|                  P=0.485                  P=0.454                  P=0.245                  P=0.525         | 
|COCH-ARM / FISHERS |                  P=0.516                  P=0.500                  P=0.227                  P=0.590         | 
|ORDER RESTRICTED   |                  P=0.502                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Complex                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                1/50 (2%)                0/50 (0%)                0/49 (0%)       | 
|POLY-3 RATE (b)    |                  2/43.15                  1/43.15                  0/44.15                  0/41.84         | 
|POLY-3 PERCENT (g) |                  4.6%                     2.3%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/28 (0%)                0/29 (0%)                0/26 (0%)       | 
|FIRST INCIDENCE    |                  655                      681                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.111N                 P=0.511N                 P=0.241N                 P=0.269N        | 
|POLY 3             |                  P=0.101N                 P=0.500N                 P=0.232N                 P=0.244N        | 
|POLY 1.5           |                  P=0.102N                 P=0.498N                 P=0.233N                 P=0.241N        | 
|POLY 6             |                  P=0.101N                 P=0.506N                 P=0.234N                 P=0.250N        | 
|LOGISTIC REGRESSION|                  P=0.103N                 P=0.501N                 P=0.239N                 P=0.242N        | 
|COCH-ARM / FISHERS |                  P=0.102N                 P=0.500N                 P=0.247N                 P=0.253N        | 
|ORDER RESTRICTED   |                  P=0.078N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/15/03                           EXPERIMENT: 96018 TEST: 03                                            Page 2       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Malignant                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                0/50 (0%)                1/50 (2%)                2/49 (4%)       | 
|POLY-3 RATE (b)    |                  1/42.84                  0/42.97                  1/44.15                  2/41.87         | 
|POLY-3 PERCENT (g) |                  2.3%                     0.0%                     2.3%                     4.8%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/28 (0%)                1/29 (3%)                1/26 (4%)       | 
|FIRST INCIDENCE    |                  718                      ---                      729 (T)                  722             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.221                  P=0.527N                 P=0.760                  P=0.452         | 
|POLY 3             |                  P=0.242                  P=0.499N                 P=0.754N                 P=0.492         | 
|POLY 1.5           |                  P=0.243                  P=0.499N                 P=0.755N                 P=0.495         | 
|POLY 6             |                  P=0.238                  P=0.502N                 P=0.755N                 P=0.484         | 
|LOGISTIC REGRESSION|                  P=0.222                  P=0.505N                 P=0.760N                 P=0.465         | 
|COCH-ARM / FISHERS |                  P=0.242                  P=0.500N                 P=0.753N                 P=0.492         | 
|ORDER RESTRICTED   |                  P=0.216                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  11/50 (22%)              10/50 (20%)              13/50 (26%)              9/49 (18%)      | 
|POLY-3 RATE (b)    |                  11/43.22                 10/43.49                 13/45.17                 9/42.22         | 
|POLY-3 PERCENT (g) |                  25.5%                    23.0%                    28.8%                    21.3%           | 
|TERMINAL (d)       |                  7/29 (24%)               6/28 (21%)               6/29 (21%)               5/26 (19%)      | 
|FIRST INCIDENCE    |                  655                      681                      649                      693             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.505N                 P=0.549N                 P=0.417                  P=0.518N        | 
|POLY 3             |                  P=0.417N                 P=0.494N                 P=0.455                  P=0.422N        | 
|POLY 1.5           |                  P=0.412N                 P=0.492N                 P=0.440                  P=0.416N        | 
|POLY 6             |                  P=0.436N                 P=0.505N                 P=0.466                  P=0.444N        | 
|LOGISTIC REGRESSION|                  P=0.442N                 P=0.520N                 P=0.440                  P=0.469N        | 
|COCH-ARM / FISHERS |                  P=0.418N                 P=0.500N                 P=0.408                  P=0.421N        | 
|ORDER RESTRICTED   |                  P=0.499N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/15/03                           EXPERIMENT: 96018 TEST: 03                                            Page 3       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Oligodendroglioma, Glioma, or Astrocytoma                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                1/50 (2%)                0/50 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  2/42.79                  1/43.34                  0/44.15                  0/42.45         | 
|POLY-3 PERCENT (g) |                  4.7%                     2.3%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  2/29 (7%)                0/28 (0%)                0/29 (0%)                0/26 (0%)       | 
|FIRST INCIDENCE    |                  729 (T)                  624                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.105N                 P=0.503N                 P=0.238N                 P=0.262N        | 
|POLY 3             |                  P=0.100N                 P=0.496N                 P=0.230N                 P=0.239N        | 
|POLY 1.5           |                  P=0.100N                 P=0.496N                 P=0.232N                 P=0.237N        | 
|POLY 6             |                  P=0.100N                 P=0.498N                 P=0.230N                 P=0.245N        | 
|LOGISTIC REGRESSION|                  P=0.100N                 P=0.499N                 (e)                      (e)             | 
|COCH-ARM / FISHERS |                  P=0.101N                 P=0.500N                 P=0.247N                 P=0.247N        | 
|ORDER RESTRICTED   |                  P=0.075N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                2/50 (4%)                3/50 (6%)                0/49 (0%)       | 
|POLY-3 RATE (b)    |                  2/43.54                  2/42.97                  3/44.15                  0/41.45         | 
|POLY-3 PERCENT (g) |                  4.6%                     4.7%                     6.8%                     0.0%            | 
|TERMINAL (d)       |                  1/29 (3%)                2/28 (7%)                3/29 (10%)               0/25 (0%)       | 
|FIRST INCIDENCE    |                  459                      729 (T)                  729 (T)                  ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.227N                 P=0.686                  P=0.502                  P=0.254N        | 
|POLY 3             |                  P=0.213N                 P=0.689                  P=0.506                  P=0.248N        | 
|POLY 1.5           |                  P=0.207N                 P=0.692                  P=0.506                  P=0.244N        | 
|POLY 6             |                  P=0.224N                 P=0.683                  P=0.503                  P=0.256N        | 
|LOGISTIC REGRESSION|                  P=0.204N                 P=0.688                  P=0.486                  P=0.275N        | 
|COCH-ARM / FISHERS |                  P=0.204N                 P=0.691N                 P=0.500                  P=0.253N        | 
|ORDER RESTRICTED   |                  P=0.166N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/15/03                           EXPERIMENT: 96018 TEST: 03                                            Page 4       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                3/50 (6%)                0/50 (0%)                1/49 (2%)       | 
|POLY-3 RATE (b)    |                  1/42.82                  3/43.65                  0/44.15                  1/41.45         | 
|POLY-3 PERCENT (g) |                  2.3%                     6.9%                     0.0%                     2.4%            | 
|TERMINAL (d)       |                  0/29 (0%)                1/28 (4%)                0/29 (0%)                1/25 (4%)       | 
|FIRST INCIDENCE    |                  722                      556                      ---                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.440N                 P=0.295                  P=0.500N                 P=0.728         | 
|POLY 3             |                  P=0.414N                 P=0.312                  P=0.494N                 P=0.754         | 
|POLY 1.5           |                  P=0.413N                 P=0.311                  P=0.495N                 P=0.756         | 
|POLY 6             |                  P=0.420N                 P=0.310                  P=0.494N                 P=0.747         | 
|LOGISTIC REGRESSION|                  P=0.416N                 P=0.303                  P=0.497N                 P=0.730         | 
|COCH-ARM / FISHERS |                  P=0.416N                 P=0.309                  P=0.500N                 P=0.747         | 
|ORDER RESTRICTED   |                  P=0.277N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                5/50 (10%)               3/50 (6%)                1/49 (2%)       | 
|POLY-3 RATE (b)    |                  3/43.57                  5/43.65                  3/44.15                  1/41.45         | 
|POLY-3 PERCENT (g) |                  6.9%                     11.5%                    6.8%                     2.4%            | 
|TERMINAL (d)       |                  1/29 (3%)                3/28 (11%)               3/29 (10%)               1/25 (4%)       | 
|FIRST INCIDENCE    |                  459                      556                      729 (T)                  729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.191N                 P=0.344                  P=0.660N                 P=0.345N        | 
|POLY 3             |                  P=0.172N                 P=0.357                  P=0.657N                 P=0.323N        | 
|POLY 1.5           |                  P=0.166N                 P=0.359                  P=0.657N                 P=0.317N        | 
|POLY 6             |                  P=0.184N                 P=0.350                  P=0.661N                 P=0.336N        | 
|LOGISTIC REGRESSION|                  P=0.163N                 P=0.348                  P=0.659                  P=0.318N        | 
|COCH-ARM / FISHERS |                  P=0.163N                 P=0.357                  P=0.661N                 P=0.316N        | 
|ORDER RESTRICTED   |                  P=0.173N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/15/03                           EXPERIMENT: 96018 TEST: 03                                            Page 5       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/49 (6%)                1/50 (2%)                5/50 (10%)               3/49 (6%)       | 
|POLY-3 RATE (b)    |                  3/42.65                  1/42.97                  5/44.39                  3/42.01         | 
|POLY-3 PERCENT (g) |                  7.0%                     2.3%                     11.3%                    7.1%            | 
|TERMINAL (d)       |                  2/29 (7%)                1/28 (4%)                2/29 (7%)                2/26 (8%)       | 
|FIRST INCIDENCE    |                  722                      729 (T)                  697                      686             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.372                  P=0.325N                 P=0.360                  P=0.612         | 
|POLY 3             |                  P=0.411                  P=0.302N                 P=0.378                  P=0.656         | 
|POLY 1.5           |                  P=0.416                  P=0.299N                 P=0.376                  P=0.660         | 
|POLY 6             |                  P=0.401                  P=0.308N                 P=0.378                  P=0.646         | 
|LOGISTIC REGRESSION|                  P=0.384                  P=0.331N                 P=0.366                  P=0.626         | 
|COCH-ARM / FISHERS |                  P=0.417                  P=0.301N                 P=0.369                  P=0.661N        | 
|ORDER RESTRICTED   |                  P=0.326                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/49 (6%)                2/50 (4%)                6/50 (12%)               4/49 (8%)       | 
|POLY-3 RATE (b)    |                  3/42.65                  2/43.20                  6/44.62                  4/42.23         | 
|POLY-3 PERCENT (g) |                  7.0%                     4.6%                     13.5%                    9.5%            | 
|TERMINAL (d)       |                  2/29 (7%)                1/28 (4%)                2/29 (7%)                2/26 (8%)       | 
|FIRST INCIDENCE    |                  722                      667                      667                      672             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.264                  P=0.516N                 P=0.253                  P=0.445         | 
|POLY 3             |                  P=0.300                  P=0.494N                 P=0.264                  P=0.495         | 
|POLY 1.5           |                  P=0.305                  P=0.492N                 P=0.261                  P=0.499         | 
|POLY 6             |                  P=0.291                  P=0.500N                 P=0.266                  P=0.485         | 
|LOGISTIC REGRESSION|                  P=0.291                  P=0.506N                 P=0.256                  P=0.474         | 
|COCH-ARM / FISHERS |                  P=0.306                  P=0.490N                 P=0.254                  P=0.500         | 
|ORDER RESTRICTED   |                  P=0.282                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/15/03                           EXPERIMENT: 96018 TEST: 03                                            Page 6       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Adenoma                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/49 (2%)                2/50 (4%)                3/50 (6%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  1/42.62                  2/43.14                  3/44.15                  0/42.45         | 
|POLY-3 PERCENT (g) |                  2.4%                     4.6%                     6.8%                     0.0%            | 
|TERMINAL (d)       |                  1/29 (3%)                1/28 (4%)                3/29 (10%)               0/26 (0%)       | 
|FIRST INCIDENCE    |                  729 (T)                  683                      729 (T)                  ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.367N                 P=0.489                  P=0.304                  P=0.522N        | 
|POLY 3             |                  P=0.342N                 P=0.504                  P=0.318                  P=0.501N        | 
|POLY 1.5           |                  P=0.336N                 P=0.506                  P=0.317                  P=0.498N        | 
|POLY 6             |                  P=0.356N                 P=0.500                  P=0.316                  P=0.507N        | 
|LOGISTIC REGRESSION|                  P=0.359N                 P=0.497                  P=0.304                  (e)             | 
|COCH-ARM / FISHERS |                  P=0.332N                 P=0.508                  P=0.316                  P=0.495N        | 
|ORDER RESTRICTED   |                  P=0.193N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                0/50 (0%)                2/50 (4%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  1/42.98                  0/42.97                  2/44.73                  0/42.45         | 
|POLY-3 PERCENT (g) |                  2.3%                     0.0%                     4.5%                     0.0%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/28 (0%)                1/29 (3%)                0/26 (0%)       | 
|FIRST INCIDENCE    |                  680                      ---                      548                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.474N                 P=0.505N                 P=0.504                  P=0.522N        | 
|POLY 3             |                  P=0.465N                 P=0.500N                 P=0.514                  P=0.503N        | 
|POLY 1.5           |                  P=0.462N                 P=0.499N                 P=0.510                  P=0.500N        | 
|POLY 6             |                  P=0.472N                 P=0.504N                 P=0.514                  P=0.509N        | 
|LOGISTIC REGRESSION|                  P=0.473N                 P=0.501N                 P=0.466                  P=0.500N        | 
|COCH-ARM / FISHERS |                  P=0.461N                 P=0.500N                 P=0.500                  P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.328N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/15/03                           EXPERIMENT: 96018 TEST: 03                                            Page 7       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                1/50 (2%)                2/50 (4%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  1/42.98                  1/42.97                  2/44.73                  0/42.45         | 
|POLY-3 PERCENT (g) |                  2.3%                     2.3%                     4.5%                     0.0%            | 
|TERMINAL (d)       |                  0/29 (0%)                1/28 (4%)                1/29 (3%)                0/26 (0%)       | 
|FIRST INCIDENCE    |                  680                      729 (T)                  548                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.384N                 P=0.753                  P=0.504                  P=0.522N        | 
|POLY 3             |                  P=0.370N                 P=0.761                  P=0.514                  P=0.503N        | 
|POLY 1.5           |                  P=0.367N                 P=0.760N                 P=0.510                  P=0.500N        | 
|POLY 6             |                  P=0.380N                 P=0.757                  P=0.514                  P=0.509N        | 
|LOGISTIC REGRESSION|                  P=0.370N                 P=0.762N                 P=0.466                  P=0.500N        | 
|COCH-ARM / FISHERS |                  P=0.366N                 P=0.753N                 P=0.500                  P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.279N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroadenoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                4/50 (8%)                2/50 (4%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  1/42.79                  4/42.97                  2/44.38                  2/42.45         | 
|POLY-3 PERCENT (g) |                  2.3%                     9.3%                     4.5%                     4.7%            | 
|TERMINAL (d)       |                  1/29 (3%)                4/28 (14%)               1/29 (3%)                2/26 (8%)       | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  669                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.527                  P=0.166                  P=0.503                  P=0.462         | 
|POLY 3             |                  P=0.566                  P=0.179                  P=0.513                  P=0.497         | 
|POLY 1.5           |                  P=0.571                  P=0.181                  P=0.509                  P=0.501         | 
|POLY 6             |                  P=0.551                  P=0.174                  P=0.514                  P=0.488         | 
|LOGISTIC REGRESSION|                  P=0.535                  P=0.166                  P=0.510                  P=0.462         | 
|COCH-ARM / FISHERS |                  P=0.569                  P=0.181                  P=0.500                  P=0.500         | 
|ORDER RESTRICTED   |                  P=0.342                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/15/03                           EXPERIMENT: 96018 TEST: 03                                            Page 8       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma or Adenoma                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                4/50 (8%)                2/50 (4%)                3/50 (6%)       | 
|POLY-3 RATE (b)    |                  2/42.79                  4/42.97                  2/44.38                  3/42.58         | 
|POLY-3 PERCENT (g) |                  4.7%                     9.3%                     4.5%                     7.1%            | 
|TERMINAL (d)       |                  2/29 (7%)                4/28 (14%)               1/29 (3%)                2/26 (8%)       | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  669                      695             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.472                  P=0.318                  P=0.692N                 P=0.450         | 
|POLY 3             |                  P=0.520                  P=0.338                  P=0.681N                 P=0.498         | 
|POLY 1.5           |                  P=0.524                  P=0.340                  P=0.684N                 P=0.502         | 
|POLY 6             |                  P=0.509                  P=0.331                  P=0.680N                 P=0.487         | 
|LOGISTIC REGRESSION|                  P=0.488                  P=0.318                  P=0.685N                 P=0.458         | 
|COCH-ARM / FISHERS |                  P=0.521                  P=0.339                  P=0.691N                 P=0.500         | 
|ORDER RESTRICTED   |                  P=0.517                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                4/50 (8%)                2/50 (4%)                3/50 (6%)       | 
|POLY-3 RATE (b)    |                  2/42.79                  4/42.97                  2/44.38                  3/42.58         | 
|POLY-3 PERCENT (g) |                  4.7%                     9.3%                     4.5%                     7.1%            | 
|TERMINAL (d)       |                  2/29 (7%)                4/28 (14%)               1/29 (3%)                2/26 (8%)       | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  669                      695             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.472                  P=0.318                  P=0.692N                 P=0.450         | 
|POLY 3             |                  P=0.520                  P=0.338                  P=0.681N                 P=0.498         | 
|POLY 1.5           |                  P=0.524                  P=0.340                  P=0.684N                 P=0.502         | 
|POLY 6             |                  P=0.509                  P=0.331                  P=0.680N                 P=0.487         | 
|LOGISTIC REGRESSION|                  P=0.488                  P=0.318                  P=0.685N                 P=0.458         | 
|COCH-ARM / FISHERS |                  P=0.521                  P=0.339                  P=0.691N                 P=0.500         | 
|ORDER RESTRICTED   |                  P=0.517                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/15/03                           EXPERIMENT: 96018 TEST: 03                                            Page 9       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/49 (6%)                1/50 (2%)                4/50 (8%)                4/49 (8%)       | 
|POLY-3 RATE (b)    |                  3/42.67                  1/42.97                  4/44.16                  4/42.02         | 
|POLY-3 PERCENT (g) |                  7.0%                     2.3%                     9.1%                     9.5%            | 
|TERMINAL (d)       |                  2/29 (7%)                1/28 (4%)                3/29 (10%)               2/26 (8%)       | 
|FIRST INCIDENCE    |                  718                      729 (T)                  727                      705             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.229                  P=0.328N                 P=0.503                  P=0.433         | 
|POLY 3             |                  P=0.266                  P=0.302N                 P=0.519                  P=0.492         | 
|POLY 1.5           |                  P=0.269                  P=0.300N                 P=0.518                  P=0.497         | 
|POLY 6             |                  P=0.258                  P=0.308N                 P=0.516                  P=0.479         | 
|LOGISTIC REGRESSION|                  P=0.229                  P=0.329N                 P=0.502                  P=0.452         | 
|COCH-ARM / FISHERS |                  P=0.270                  P=0.301N                 P=0.511                  P=0.500         | 
|ORDER RESTRICTED   |                  P=0.305                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  22/49 (45%)              29/50 (58%)              28/50 (56%)              26/48 (54%)     | 
|POLY-3 RATE (b)    |                  22/44.57                 29/46.34                 28/47.16                 26/44.23        | 
|POLY-3 PERCENT (g) |                  49.4%                    62.6%                    59.4%                    58.8%           | 
|TERMINAL (d)       |                  13/29 (45%)              17/28 (61%)              17/29 (59%)              12/25 (48%)     | 
|FIRST INCIDENCE    |                  459                      526                      430                      486             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.210                  P=0.128                  P=0.207                  P=0.175         | 
|POLY 3             |                  P=0.300                  P=0.140                  P=0.222                  P=0.245         | 
|POLY 1.5           |                  P=0.303                  P=0.139                  P=0.212                  P=0.248         | 
|POLY 6             |                  P=0.288                  P=0.139                  P=0.221                  P=0.235         | 
|LOGISTIC REGRESSION|                  P=0.293                  P=0.139                  P=0.199                  P=0.240         | 
|COCH-ARM / FISHERS |                  P=0.289                  P=0.135                  P=0.183                  P=0.239         | 
|ORDER RESTRICTED   |                  P=0.234                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/15/03                           EXPERIMENT: 96018 TEST: 03                                            Page 10      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous                                                                      | 
|     Tumor (benign, malignant or NOS), or Trichoepithelioma                                                                      | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                0/50 (0%)                1/50 (2%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  2/42.82                  0/42.97                  1/44.15                  1/42.45         | 
|POLY-3 PERCENT (g) |                  4.7%                     0.0%                     2.3%                     2.4%            | 
|TERMINAL (d)       |                  1/29 (3%)                0/28 (0%)                1/29 (3%)                1/26 (4%)       | 
|FIRST INCIDENCE    |                  722                      ---                      729 (T)                  729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.530N                 P=0.255N                 P=0.500N                 P=0.541N        | 
|POLY 3             |                  P=0.500N                 P=0.236N                 P=0.489N                 P=0.503N        | 
|POLY 1.5           |                  P=0.500N                 P=0.236N                 P=0.492N                 P=0.499N        | 
|POLY 6             |                  P=0.501N                 P=0.239N                 P=0.490N                 P=0.513N        | 
|LOGISTIC REGRESSION|                  P=0.531N                 P=0.251N                 P=0.498N                 P=0.544N        | 
|COCH-ARM / FISHERS |                  P=0.500N                 P=0.247N                 P=0.500N                 P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.272N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       | 
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  4/50 (8%)                1/50 (2%)                2/50 (4%)                5/50 (10%)      | 
|POLY-3 RATE (b)    |                  4/42.82                  1/42.97                  2/44.15                  5/42.98         | 
|POLY-3 PERCENT (g) |                  9.3%                     2.3%                     4.5%                     11.6%           | 
|TERMINAL (d)       |                  3/29 (10%)               1/28 (4%)                2/29 (7%)                3/26 (12%)      | 
|FIRST INCIDENCE    |                  722                      729 (T)                  729 (T)                  642             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.231                  P=0.195N                 P=0.337N                 P=0.437         | 
|POLY 3             |                  P=0.274                  P=0.177N                 P=0.323N                 P=0.502         | 
|POLY 1.5           |                  P=0.275                  P=0.176N                 P=0.326N                 P=0.505         | 
|POLY 6             |                  P=0.271                  P=0.181N                 P=0.323N                 P=0.492         | 
|LOGISTIC REGRESSION|                  P=0.250                  P=0.201N                 P=0.332N                 P=0.477         | 
|COCH-ARM / FISHERS |                  P=0.273                  P=0.181N                 P=0.339N                 P=0.500         | 
|ORDER RESTRICTED   |                  P=0.200                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/15/03                           EXPERIMENT: 96018 TEST: 03                                            Page 11      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  6/50 (12%)               8/50 (16%)               10/50 (20%)              6/50 (12%)      | 
|POLY-3 RATE (b)    |                  6/42.87                  8/44.42                  10/45.20                 6/42.84         | 
|POLY-3 PERCENT (g) |                  14.0%                    18.0%                    22.1%                    14.0%           | 
|TERMINAL (d)       |                  5/29 (17%)               5/28 (18%)               5/29 (17%)               3/26 (12%)      | 
|FIRST INCIDENCE    |                  709                      526                      642                      686             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.501                  P=0.366                  P=0.214                  P=0.541         | 
|POLY 3             |                  P=0.534N                 P=0.413                  P=0.238                  P=0.621         | 
|POLY 1.5           |                  P=0.526N                 P=0.406                  P=0.227                  P=0.617N        | 
|POLY 6             |                  P=0.553                  P=0.416                  P=0.248                  P=0.608         | 
|LOGISTIC REGRESSION|                  P=0.530N                 P=0.390                  P=0.224                  P=0.573         | 
|COCH-ARM / FISHERS |                  P=0.527N                 P=0.387                  P=0.207                  P=0.620N        | 
|ORDER RESTRICTED   |                  P=0.482                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  7/50 (14%)               9/50 (18%)               10/50 (20%)              7/50 (14%)      | 
|POLY-3 RATE (b)    |                  7/42.87                  9/44.42                  10/45.20                 7/43.19         | 
|POLY-3 PERCENT (g) |                  16.3%                    20.3%                    22.1%                    16.2%           | 
|TERMINAL (d)       |                  6/29 (21%)               6/28 (21%)               5/29 (17%)               3/26 (12%)      | 
|FIRST INCIDENCE    |                  709                      526                      642                      633             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.509                  P=0.369                  P=0.302                  P=0.535         | 
|POLY 3             |                  P=0.511N                 P=0.422                  P=0.338                  P=0.609N        | 
|POLY 1.5           |                  P=0.507N                 P=0.413                  P=0.324                  P=0.606N        | 
|POLY 6             |                  P=0.524N                 P=0.424                  P=0.351                  P=0.611         | 
|LOGISTIC REGRESSION|                  P=0.516N                 P=0.396                  P=0.320                  P=0.583         | 
|COCH-ARM / FISHERS |                  P=0.513N                 P=0.393                  P=0.298                  P=0.613N        | 
|ORDER RESTRICTED   |                  P=0.539N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/15/03                           EXPERIMENT: 96018 TEST: 03                                            Page 12      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Keratoacanthoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                1/50 (2%)                2/50 (4%)                3/50 (6%)       | 
|POLY-3 RATE (b)    |                  3/42.82                  1/42.97                  2/44.15                  3/42.76         | 
|POLY-3 PERCENT (g) |                  7.0%                     2.3%                     4.5%                     7.0%            | 
|TERMINAL (d)       |                  2/29 (7%)                1/28 (4%)                2/29 (7%)                2/26 (8%)       | 
|FIRST INCIDENCE    |                  722                      729 (T)                  729 (T)                  642             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.434                  P=0.325N                 P=0.500N                 P=0.613         | 
|POLY 3             |                  P=0.477                  P=0.304N                 P=0.486N                 P=0.662         | 
|POLY 1.5           |                  P=0.479                  P=0.303N                 P=0.489N                 P=0.660N        | 
|POLY 6             |                  P=0.471                  P=0.308N                 P=0.487N                 P=0.653         | 
|LOGISTIC REGRESSION|                  P=0.451                  P=0.331N                 P=0.498N                 P=0.645         | 
|COCH-ARM / FISHERS |                  P=0.477                  P=0.309N                 P=0.500N                 P=0.661N        | 
|ORDER RESTRICTED   |                  P=0.489                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma, Papilloma, Squamous Cell                                                                           | 
|     Carcinoma or Keratoacanthoma                                                                                                | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                1/50 (2%)                2/50 (4%)                4/50 (8%)       | 
|POLY-3 RATE (b)    |                  3/42.82                  1/42.97                  2/44.15                  4/42.98         | 
|POLY-3 PERCENT (g) |                  7.0%                     2.3%                     4.5%                     9.3%            | 
|TERMINAL (d)       |                  2/29 (7%)                1/28 (4%)                2/29 (7%)                2/26 (8%)       | 
|FIRST INCIDENCE    |                  722                      729 (T)                  729 (T)                  642             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.253                  P=0.325N                 P=0.500N                 P=0.446         | 
|POLY 3             |                  P=0.293                  P=0.304N                 P=0.486N                 P=0.502         | 
|POLY 1.5           |                  P=0.294                  P=0.303N                 P=0.489N                 P=0.504         | 
|POLY 6             |                  P=0.290                  P=0.308N                 P=0.487N                 P=0.493         | 
|LOGISTIC REGRESSION|                  P=0.275                  P=0.331N                 P=0.498N                 P=0.488         | 
|COCH-ARM / FISHERS |                  P=0.292                  P=0.309N                 P=0.500N                 P=0.500         | 
|ORDER RESTRICTED   |                  P=0.281                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/15/03                           EXPERIMENT: 96018 TEST: 03                                            Page 13      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                1/50 (2%)                2/50 (4%)                4/50 (8%)       | 
|POLY-3 RATE (b)    |                  3/42.82                  1/42.97                  2/44.15                  4/42.98         | 
|POLY-3 PERCENT (g) |                  7.0%                     2.3%                     4.5%                     9.3%            | 
|TERMINAL (d)       |                  2/29 (7%)                1/28 (4%)                2/29 (7%)                2/26 (8%)       | 
|FIRST INCIDENCE    |                  722                      729 (T)                  729 (T)                  642             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.253                  P=0.325N                 P=0.500N                 P=0.446         | 
|POLY 3             |                  P=0.293                  P=0.304N                 P=0.486N                 P=0.502         | 
|POLY 1.5           |                  P=0.294                  P=0.303N                 P=0.489N                 P=0.504         | 
|POLY 6             |                  P=0.290                  P=0.308N                 P=0.487N                 P=0.493         | 
|LOGISTIC REGRESSION|                  P=0.275                  P=0.331N                 P=0.498N                 P=0.488         | 
|COCH-ARM / FISHERS |                  P=0.292                  P=0.309N                 P=0.500N                 P=0.500         | 
|ORDER RESTRICTED   |                  P=0.281                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  45/50 (90%)              47/50 (94%)              41/50 (82%)              47/50 (94%)     | 
|POLY-3 RATE (b)    |                  45/47.36                 47/48.65                 41/47.64                 47/49.02        | 
|POLY-3 PERCENT (g) |                  95.0%                    96.6%                    86.1%                    95.9%           | 
|TERMINAL (d)       |                  28/29 (97%)              28/28 (100%)             26/29 (90%)              25/26 (96%)     | 
|FIRST INCIDENCE    |                  405                      498                      526                      448             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.240                  P=0.343                  P=0.294N                 P=0.212         | 
|POLY 3             |                  P=0.538N                 P=0.559                  P=0.102N                 P=0.629         | 
|POLY 1.5           |                  P=0.565                  P=0.469                  P=0.124N                 P=0.518         | 
|POLY 6             |                  P=0.494N                 P=0.647                  P=0.100N                 P=0.728         | 
|LOGISTIC REGRESSION|                  P=0.528                  P=0.473                  P=0.077N                 P=0.467         | 
|COCH-ARM / FISHERS |                  P=0.437                  P=0.357                  P=0.194N                 P=0.357         | 
|ORDER RESTRICTED   |                  P=0.224N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/15/03                           EXPERIMENT: 96018 TEST: 03                                            Page 14      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  8/46 (17%)               6/48 (13%)               10/44 (23%)              7/42 (17%)      | 
|POLY-3 RATE (b)    |                  8/41.34                  6/41.66                  10/39.78                 7/37.14         | 
|POLY-3 PERCENT (g) |                  19.4%                    14.4%                    25.1%                    18.9%           | 
|TERMINAL (d)       |                  5/29 (17%)               5/28 (18%)               8/29 (28%)               7/26 (27%)      | 
|FIRST INCIDENCE    |                  526                      624                      709                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.487                  P=0.401N                 P=0.400                  P=0.579N        | 
|POLY 3             |                  P=0.462                  P=0.379N                 P=0.360                  P=0.591N        | 
|POLY 1.5           |                  P=0.467                  P=0.366N                 P=0.362                  P=0.581N        | 
|POLY 6             |                  P=0.447                  P=0.403N                 P=0.350                  P=0.612N        | 
|LOGISTIC REGRESSION|                  P=0.488                  P=0.355N                 P=0.379                  P=0.567N        | 
|COCH-ARM / FISHERS |                  P=0.465                  P=0.354N                 P=0.356                  P=0.577N        | 
|ORDER RESTRICTED   |                  P=0.445                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/46 (2%)                1/48 (2%)                1/44 (2%)                4/42 (10%)      | 
|POLY-3 RATE (b)    |                  1/40.05                  1/41.28                  1/39.67                  4/37.54         | 
|POLY-3 PERCENT (g) |                  2.5%                     2.4%                     2.5%                     10.7%           | 
|TERMINAL (d)       |                  1/29 (3%)                1/28 (4%)                1/29 (3%)                2/26 (8%)       | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  729 (T)                  642             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.055                  P=0.754                  P=0.762                  P=0.154         | 
|POLY 3             |                  P=0.054                  P=0.754N                 P=0.759                  P=0.158         | 
|POLY 1.5           |                  P=0.053                  P=0.752N                 P=0.756                  P=0.156         | 
|POLY 6             |                  P=0.055                  P=0.758N                 P=0.761                  P=0.158         | 
|LOGISTIC REGRESSION|                  P=0.054                  P=0.754                  P=0.762                  P=0.156         | 
|COCH-ARM / FISHERS |                  P=0.051                  P=0.742N                 P=0.742                  P=0.153         | 
|ORDER RESTRICTED   |                  P=0.059                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/15/03                           EXPERIMENT: 96018 TEST: 03                                            Page 15      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  9/46 (20%)               7/48 (15%)               11/44 (25%)              11/42 (26%)     | 
|POLY-3 RATE (b)    |                  9/41.34                  7/41.66                  11/39.78                 11/37.54        | 
|POLY-3 PERCENT (g) |                  21.8%                    16.8%                    27.7%                    29.3%           | 
|TERMINAL (d)       |                  6/29 (21%)               6/28 (21%)               9/29 (31%)               9/26 (35%)      | 
|FIRST INCIDENCE    |                  526                      624                      709                      642             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.179                  P=0.409N                 P=0.404                  P=0.312         | 
|POLY 3             |                  P=0.164                  P=0.384N                 P=0.360                  P=0.305         | 
|POLY 1.5           |                  P=0.166                  P=0.370N                 P=0.363                  P=0.312         | 
|POLY 6             |                  P=0.159                  P=0.410N                 P=0.350                  P=0.290         | 
|LOGISTIC REGRESSION|                  P=0.178                  P=0.360N                 P=0.385                  P=0.324         | 
|COCH-ARM / FISHERS |                  P=0.164                  P=0.357N                 P=0.357                  P=0.313         | 
|ORDER RESTRICTED   |                  P=0.237                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/46 (0%)                2/48 (4%)                0/44 (0%)                0/42 (0%)       | 
|POLY-3 RATE (b)    |                  0/40.05                  2/41.36                  0/39.67                  0/37.14         | 
|POLY-3 PERCENT (g) |                  0.0%                     4.8%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  0/29 (0%)                1/28 (4%)                0/29 (0%)                0/26 (0%)       | 
|FIRST INCIDENCE    |                  ---                      709                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.425N                 P=0.226                  (e)                      (e)             | 
|POLY 3             |                  P=0.423N                 P=0.244                  (e)                      (e)             | 
|POLY 1.5           |                  P=0.423N                 P=0.246                  (e)                      (e)             | 
|POLY 6             |                  P=0.424N                 P=0.240                  (e)                      (e)             | 
|LOGISTIC REGRESSION|                  P=0.422N                 P=0.236                  (e)                      (e)             | 
|COCH-ARM / FISHERS |                  P=0.427N                 P=0.258                  (e)                      (e)             | 
|ORDER RESTRICTED   |                  P=0.269N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/15/03                           EXPERIMENT: 96018 TEST: 03                                            Page 16      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/46 (0%)                2/48 (4%)                1/44 (2%)                0/42 (0%)       | 
|POLY-3 RATE (b)    |                  0/40.05                  2/41.36                  1/39.67                  0/37.14         | 
|POLY-3 PERCENT (g) |                  0.0%                     4.8%                     2.5%                     0.0%            | 
|TERMINAL (d)       |                  0/29 (0%)                1/28 (4%)                1/29 (3%)                0/26 (0%)       | 
|FIRST INCIDENCE    |                  ---                      709                      729 (T)                  ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.486N                 P=0.226                  P=0.500                  (e)             | 
|POLY 3             |                  P=0.483N                 P=0.244                  P=0.498                  (e)             | 
|POLY 1.5           |                  P=0.484N                 P=0.246                  P=0.496                  (e)             | 
|POLY 6             |                  P=0.485N                 P=0.240                  P=0.500                  (e)             | 
|LOGISTIC REGRESSION|                  P=0.483N                 P=0.236                  P=0.500                  (e)             | 
|COCH-ARM / FISHERS |                  P=0.489N                 P=0.258                  P=0.489                  (e)             | 
|ORDER RESTRICTED   |                  P=0.332                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           | 
|     Undifferentiated                                                                                                            | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  16/50 (32%)              18/50 (36%)              16/50 (32%)              15/50 (30%)     | 
|POLY-3 RATE (b)    |                  16/45.79                 18/45.77                 16/45.70                 15/45.00        | 
|POLY-3 PERCENT (g) |                  34.9%                    39.3%                    35.0%                    33.3%           | 
|TERMINAL (d)       |                  4/29 (14%)               7/28 (25%)               9/29 (31%)               7/26 (27%)      | 
|FIRST INCIDENCE    |                  479                      405                      561                      616             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.501N                 P=0.385                  P=0.568N                 P=0.558         | 
|POLY 3             |                  P=0.413N                 P=0.413                  P=0.584                  P=0.524N        | 
|POLY 1.5           |                  P=0.397N                 P=0.424                  P=0.579N                 P=0.507N        | 
|POLY 6             |                  P=0.446N                 P=0.386                  P=0.556                  P=0.560N        | 
|LOGISTIC REGRESSION|                  P=0.391N                 P=0.410                  P=0.584                  P=0.503N        | 
|COCH-ARM / FISHERS |                  P=0.389N                 P=0.417                  P=0.585N                 P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.553N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/15/03                           EXPERIMENT: 96018 TEST: 03                                            Page 17      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Benign, Malignant, NOS                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                3/50 (6%)                3/50 (6%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  3/42.79                  3/43.15                  3/44.78                  2/42.45         | 
|POLY-3 PERCENT (g) |                  7.0%                     7.0%                     6.7%                     4.7%            | 
|TERMINAL (d)       |                  3/29 (10%)               2/28 (7%)                2/29 (7%)                2/26 (8%)       | 
|FIRST INCIDENCE    |                  729 (T)                  681                      526                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.438N                 P=0.650                  P=0.658N                 P=0.551N        | 
|POLY 3             |                  P=0.399N                 P=0.659N                 P=0.642N                 P=0.504N        | 
|POLY 1.5           |                  P=0.396N                 P=0.658N                 P=0.648N                 P=0.499N        | 
|POLY 6             |                  P=0.410N                 P=0.663                  P=0.639N                 P=0.516N        | 
|LOGISTIC REGRESSION|                  P=0.402N                 P=0.648                  P=0.657N                 P=0.551N        | 
|COCH-ARM / FISHERS |                  P=0.397N                 P=0.661N                 P=0.661N                 P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.525N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Malignant                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                3/50 (6%)                3/50 (6%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  3/42.79                  3/43.15                  3/44.78                  2/42.45         | 
|POLY-3 PERCENT (g) |                  7.0%                     7.0%                     6.7%                     4.7%            | 
|TERMINAL (d)       |                  3/29 (10%)               2/28 (7%)                2/29 (7%)                2/26 (8%)       | 
|FIRST INCIDENCE    |                  729 (T)                  681                      526                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.438N                 P=0.650                  P=0.658N                 P=0.551N        | 
|POLY 3             |                  P=0.399N                 P=0.659N                 P=0.642N                 P=0.504N        | 
|POLY 1.5           |                  P=0.396N                 P=0.658N                 P=0.648N                 P=0.499N        | 
|POLY 6             |                  P=0.410N                 P=0.663                  P=0.639N                 P=0.516N        | 
|LOGISTIC REGRESSION|                  P=0.402N                 P=0.648                  P=0.657N                 P=0.551N        | 
|COCH-ARM / FISHERS |                  P=0.397N                 P=0.661N                 P=0.661N                 P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.525N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/15/03                           EXPERIMENT: 96018 TEST: 03                                            Page 18      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  49/50 (98%)              49/50 (98%)              50/50 (100%)             49/50 (98%)     | 
|POLY-3 RATE (b)    |                  49/49.12                 49/49.17                 50/50.00                 49/50.00        | 
|POLY-3 PERCENT (g) |                  99.8%                    99.7%                    100.0%                   98.0%           | 
|TERMINAL (d)       |                  29/29 (100%)             28/28 (100%)             29/29 (100%)             25/26 (96%)     | 
|FIRST INCIDENCE    |                  405                      498                      430                      448             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.287                  P=0.474                  P=0.526                  P=0.318         | 
|POLY 3             |                  P=0.275N                 P=1.000N                 P=1.000                  P=0.549N        | 
|POLY 1.5           |                  P=0.422N                 P=0.956N                 P=0.974                  P=0.629N        | 
|POLY 6             |                  P=0.211N                 P=1.000N                 P=1.000                  P=0.509N        | 
|LOGISTIC REGRESSION|                  P=0.509N                 (e)                      (e)                      P=0.688N        | 
|COCH-ARM / FISHERS |                  P=0.616                  P=0.753N                 P=0.500                  P=0.753N        | 
|ORDER RESTRICTED   |                  P=0.167N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  28/50 (56%)              27/50 (54%)              27/50 (54%)              27/50 (54%)     | 
|POLY-3 RATE (b)    |                  28/48.99                 27/47.50                 27/47.83                 27/47.27        | 
|POLY-3 PERCENT (g) |                  57.2%                    56.8%                    56.5%                    57.1%           | 
|TERMINAL (d)       |                  9/29 (31%)               11/28 (39%)              14/29 (48%)              12/26 (46%)     | 
|FIRST INCIDENCE    |                  354                      405                      526                      485             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.458                  P=0.546N                 P=0.484N                 P=0.496         | 
|POLY 3             |                  P=0.538N                 P=0.569N                 P=0.554N                 P=0.581N        | 
|POLY 1.5           |                  P=0.511N                 P=0.541N                 P=0.531N                 P=0.548N        | 
|POLY 6             |                  P=0.502                  P=0.560                  P=0.577                  P=0.542         | 
|LOGISTIC REGRESSION|                  P=0.471N                 P=0.510N                 P=0.559N                 P=0.491N        | 
|COCH-ARM / FISHERS |                  P=0.471N                 P=0.500N                 P=0.500N                 P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.732N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/15/03                           EXPERIMENT: 96018 TEST: 03                                            Page 19      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  50/50 (100%)             50/50 (100%)             50/50 (100%)             49/50 (98%)     | 
|POLY-3 RATE (b)    |                  50/50.00                 50/50.00                 50/50.00                 49/50.00        | 
|POLY-3 PERCENT (g) |                  100.0%                   100.0%                   100.0%                   98.0%           | 
|TERMINAL (d)       |                  29/29 (100%)             28/28 (100%)             29/29 (100%)             25/26 (96%)     | 
|FIRST INCIDENCE    |                  354                      405                      430                      448             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.355                  (e)                      (e)                      P=0.375         | 
|POLY 3             |                  P=0.199N                 (e)                      (e)                      P=0.500N        | 
|POLY 1.5           |                  P=0.199N                 (e)                      (e)                      P=0.500N        | 
|POLY 6             |                  P=0.199N                 (e)                      (e)                      P=0.500N        | 
|LOGISTIC REGRESSION|                  (e)                      (e)                      (e)                      (e)             | 
|COCH-ARM / FISHERS |                  P=0.198N                 (e)                      (e)                      P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.121N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.