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TDMS Study 96018-03 Pathology Tables

NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04
Route: DOSED WATER                                                                                                Time: 09:32:41

                                                         FINAL #2/RATS




       Facility:  Southern Research Institute

       Chemical CAS #:  75-27-4

       Lock Date:  02/19/02

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1


NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 1| 5| 3| 3| 3| 7| 1| 3| 2| 8| 2| 0| 3| 5| 2| 3| 8| 2| 0| 2| 0| 3| 5| 3|             
                                           | 9| 0| 9| 1| 1| 1| 9| 8| 2| 9| 0| 0| 9| 0| 5| 2| 2| 3| 9| 9| 9| 9| 2| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/L                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                         2                                               2|             
      Basophilic Focus                     | X     X  X  X  X  X  X  X  X  X  X     X     X        X     X     X     X|             
      Cholangiofibrosis                    |                                                             2            |             
      Clear Cell Focus                     | X        X  X  X     X     X           X        X     X  X  X  X  X     X|             
      Congestion                           |                      3                                2                  |             
      Degeneration, Cystic, Focal          | 2        2  1  2        2  2  2  2     2     2  2     1  1  2  2  1     2|             
      Fibrosis, Focal                      |                                                             3            |             
      Hepatodiaphragmatic Nodule           |    3           3                                                         |             
      Infiltration Cellular, Mixed Cell    | 2     2  2  2        2     2     1     2  1  2  2           1     2     2|             
      Inflammation, Chronic                | 2     1     1  3                       2        1     1     2     1     1|             
      Necrosis, Focal                      |       1                                                                  |             
      Bile Duct, Hyperplasia               | 3  3  2  3  3  3  2  3  3  3  3     3  3  3  1  3  3  3  3  3  3  3  3  3|             
      Hepatocyte, Fatty Change             | 1  4     1  1     1     2        2  2           1  1  1        1  1  2   |             
      Hepatocyte, Vacuolization Cytoplasmic|    2                             2  1              2           2     2   |             
      Hepatocyte, Centrilobular, Necrosis  |                                  3                                       |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +           +  +              +                                +         |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis, Focal                 |             3  2                                                         |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               |       1     2  2        2  1  4  2  3     3  2  1     1           1     2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 1| 5| 3| 3| 3| 7| 1| 3| 2| 8| 2| 0| 3| 5| 2| 3| 8| 2| 0| 2| 0| 3| 5| 3|             
                                           | 9| 0| 9| 1| 1| 1| 9| 8| 2| 9| 0| 0| 9| 0| 5| 2| 2| 3| 9| 9| 9| 9| 2| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/L                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
      Duct, Cyst, Focal, Multiple          |             2        2              2  2           2  2              1  1|             
      Duct, Cyst                           |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                     3                                    |             
      Inflammation, Focal                  |                                     2                                    |             
      Ulcer                                |                                     3                                    |             
      Epithelium, Hyperplasia              |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Ulcer                                |                   1                                                      |             
      Epithelium, Hyperplasia, Focal       |                                                                      2   |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2              2  2                       2     1                        |             
      Infiltration Cellular, Mixed Cell    |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                   1                 1           1  1  1  1  1           1|             
      Cytoplasmic Alteration, Focal        |                               2                                          |             
      Necrosis, Focal                      |                                              1                           |             
      Vacuolization Cytoplasmic, Focal     |          1              1  2           1                             1   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |          1  1                    1              1              1         |             
      Necrosis, Focal                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 1| 5| 3| 3| 3| 7| 1| 3| 2| 8| 2| 0| 3| 5| 2| 3| 8| 2| 0| 2| 0| 3| 5| 3|             
                                           | 9| 0| 9| 1| 1| 1| 9| 8| 2| 9| 0| 0| 9| 0| 5| 2| 2| 3| 9| 9| 9| 9| 2| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/L                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Hyperplasia, Focal                   |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Craniopharyngeal Duct, Cyst          |                                                                          |             
      Pars Distalis, Cyst                  |                                                          2               |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                | 2                             1                                1  1  1   |             
      Pars Distalis, Degeneration, Cystic, |                                                                          |             
           Focal                           |       1                                                                  |             
      Pars Distalis, Hemorrhage, Focal     |                                                 2     2                  |             
      Pars Distalis, Hyperplasia, Focal    |       1                    2                                             |             
      Pars Distalis, Necrosis, Focal       |                                                                          |             
      Rathke's Cleft, Cyst                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1  3  1  2  2  2  2     3     2  2  2  3     2  1  1  2  2     1  2  1  1|             
      Follicular Cell, Hyperplasia, Cystic,|                                                                          |             
           Focal                           |                               1        1              2                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              | +                                                                        |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |    +                                                                 +   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia, Cystic                  |             3                                                            |             
      Inflammation, Chronic                |             2  3     2  2  1  2  2  1  2        1  1     2  2  2     2  2|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 1| 5| 3| 3| 3| 7| 1| 3| 2| 8| 2| 0| 3| 5| 2| 3| 8| 2| 0| 2| 0| 3| 5| 3|             
                                           | 9| 0| 9| 1| 1| 1| 9| 8| 2| 9| 0| 0| 9| 0| 5| 2| 2| 3| 9| 9| 9| 9| 2| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/L                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |          2           3  3     2  3           3     2  1     3  2  3  3  1|             
      Epithelium, Hyperplasia, Focal       | 2              2              1  2        2  2     1     1        1  2  1|             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                              3  3  3                     |             
      Necrosis                             |                                                                          |             
      Artery, Thrombosis, Focal            |                                                                          |             
      Bilateral, Atrophy                   |                                                                          |             
      Interstitial Cell, Hyperplasia, Focal|       1                                                                  |             
      Tunic, Inflammation, Chronic         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               3                          4               |             
      Myeloid Cell, Hyperplasia            |                                              3                           |             
      Myeloid Cell, Erythroid Cell,        |                                                                          |             
          Hyperplasia                      |                                  3                                       |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +  +     +     +     +     +     +              +     +     +     +   |             
      Mediastinal, Angiectasis             |       4                                                                  |             
      Mediastinal, Ectasia                 |                                                                          |             
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
      Mediastinal, Inflammation            |                                     4                                    |             
      Pancreatic, Ectasia                  |                                                                          |             
      Pancreatic, Hemorrhage               |       3                                                                  |             
      Pancreatic, Hyperplasia, Histiocytic |       3     3                                                            |             
      Pancreatic, Pigmentation             |       3                                                                  |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                         3        2                                       |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 1| 5| 3| 3| 3| 7| 1| 3| 2| 8| 2| 0| 3| 5| 2| 3| 8| 2| 0| 2| 0| 3| 5| 3|             
                                           | 9| 0| 9| 1| 1| 1| 9| 8| 2| 9| 0| 0| 9| 0| 5| 2| 2| 3| 9| 9| 9| 9| 2| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/L                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                                          X               |             
      Angiectasis, Focal                   | 2                                                                        |             
      Fibrosis, Focal                      | 2                                                     3        3         |             
      Hematopoietic Cell Proliferation     |       2  2  1                    3           3                           |             
      Hemorrhage, Chronic                  |                               3                                          |             
      Hyperplasia, Lymphoid                |       2                                                                  |             
      Infarct                              |                                                                3         |             
      Artery, Thrombosis                   |                                                                          |             
      Capsule, Fibrosis, Focal             |                2                                                         |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Dilatation                           |                                  2           2                           |             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Angiectasis,    |                                                                          |             
           Focal                           |                                                                          |             
      Subcutaneous Tissue, Cyst, Chronic   |                                           4                              |             
      Subcutaneous Tissue, Edema           |                                  3                                       |             
      Subcutaneous Tissue, Hemorrhage,     |                                                                          |             
           Focal                           |                   2                                                      |             
      Subcutaneous Tissue, Metaplasia,     |                                                                          |             
           Focal, Osseous                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 1| 5| 3| 3| 3| 7| 1| 3| 2| 8| 2| 0| 3| 5| 2| 3| 8| 2| 0| 2| 0| 3| 5| 3|             
                                           | 9| 0| 9| 1| 1| 1| 9| 8| 2| 9| 0| 0| 9| 0| 5| 2| 2| 3| 9| 9| 9| 9| 2| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/L                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |                                  1                                       |             
      Hemorrhage, Focal                    |                   2                                                      |             
      Necrosis, Focal                      |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                   +                                                     +|             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                   +                                                     +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                   2  3                    3                              |             
      Hemorrhage, Focal                    |          2                                                               |             
      Hemorrhage                           |                   2                                                      |             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
      Hyperplasia, Histiocytic             |       1                                                                  |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                1     2   |             
      Interstitium, Edema                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                     2                                    |             
                                           |__________________________________________________________________________|             
   Pleura                                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                         3|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 1| 5| 3| 3| 3| 7| 1| 3| 2| 8| 2| 0| 3| 5| 2| 3| 8| 2| 0| 2| 0| 3| 5| 3|             
                                           | 9| 0| 9| 1| 1| 1| 9| 8| 2| 9| 0| 0| 9| 0| 5| 2| 2| 3| 9| 9| 9| 9| 2| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/L                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |       +                                +                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 3  1  1  2  1  2  2  4  3  2  2  3  1  2  1  2  1  2  2  2  3  2  2  1  2|             
      Renal Tubule, Pigmentation           |       1           2              2  2  2     2     3                     |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 3| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 2| 3| 3| 0| 3| 5| 0| 3| 3| 5| 3|            |
                                           | 0| 0| 6| 0| 0| 0| 0| 4| 2| 2| 0| 2| 2| 2| 2| 0| 0| 5| 5| 4| 2| 2| 2| 3| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/L                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   | 2        2                                                               |      4  2.0|
      Basophilic Focus                     | X  X  X  X  X  X  X              X  X  X     X  X     X        X  X     X|     33     |
      Cholangiofibrosis                    |                                                                          |      1  2.0|
      Clear Cell Focus                     | X  X     X  X  X  X              X     X     X  X     X        X  X     X|     28     |
      Congestion                           |                                                                          |      2  2.5|
      Degeneration, Cystic, Focal          | 2  2     2                    2  2  2  2  2  2  2     2        2  2     2|     31  1.9|
      Fibrosis, Focal                      |                                                                          |      1  3.0|
      Hepatodiaphragmatic Nodule           |                            2        X     3                              |      5  2.8|
      Infiltration Cellular, Mixed Cell    | 2  2  2     2  2  2           2  2     2     2  2     2  2     2  2     2|     30  1.9|
      Inflammation, Chronic                | 1     2     1  2  1           2     1  1        1     1        1  1     1|     23  1.3|
      Necrosis, Focal                      |                                                          1               |      2  1.0|
      Bile Duct, Hyperplasia               | 3  3  2  3  3  3  3  3  3  3  3  3     3     3  3     3     3  3  3  2  2|     45  2.8|
      Hepatocyte, Fatty Change             | 1  1  1  1  1  1  2  3  2  2  3  1  2  1  2  1  1  1  1        1  2     1|     36  1.5|
      Hepatocyte, Vacuolization Cytoplasmic|                   2  2              2     4                          1   |     11  2.0|
      Hepatocyte, Centrilobular, Necrosis  |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +     +           +     +  +     +        +                 +     +  +   |  15        |
      Inflammation, Chronic                |                                                                      3   |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 3| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 2| 3| 3| 0| 3| 5| 0| 3| 3| 5| 3|            |
                                           | 0| 0| 6| 0| 0| 0| 0| 4| 2| 2| 0| 2| 2| 2| 2| 0| 0| 5| 5| 4| 2| 2| 2| 3| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/L                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Fat, Necrosis, Focal                 | 2     3           3        3     2                                   3   |      8  2.6|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy, Focal               | 1  1     1     3     2     2     1     1  3  2  1     4     3  1  1  2  1|     31  1.8|
      Acinus, Hyperplasia, Focal           |                                              2                           |      1  2.0|
      Duct, Cyst, Focal, Multiple          |    1        1  2           2              2           3        1        2|     16  1.8|
      Duct, Cyst                           |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                             2            |      2  2.5|
      Inflammation, Focal                  |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |                                                             2            |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Erosion                              |                                           2                 1            |      2  1.5|
      Ulcer                                |                                                                          |      1  1.0|
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2     1           2  2     2     2           2     2     1  2           2|     16  1.8|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |    1        1     1                 1  1                       1         |     14  1.0|
      Cytoplasmic Alteration, Focal        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 3| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 2| 3| 3| 0| 3| 5| 0| 3| 3| 5| 3|            |
                                           | 0| 0| 6| 0| 0| 0| 0| 4| 2| 2| 0| 2| 2| 2| 2| 0| 0| 5| 5| 4| 2| 2| 2| 3| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/L                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Necrosis, Focal                      |                                                             3            |      2  2.0|
      Vacuolization Cytoplasmic, Focal     |             1                 2                                      1  1|      9  1.2|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |             1              1        2     2     1     1                  |     11  1.2|
      Necrosis, Focal                      |                                                             3            |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                                              2                           |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          | 2                    2                                                   |      2  2.0|
      Craniopharyngeal Duct, Cyst          |                                                             2            |      1  2.0|
      Pars Distalis, Cyst                  |                                                             2            |      2  2.0|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                                                       1  3               |      7  1.4|
      Pars Distalis, Degeneration, Cystic, |                                                                          |            |
           Focal                           |                                                                          |      1  1.0|
      Pars Distalis, Hemorrhage, Focal     |                                                                      3   |      3  2.3|
      Pars Distalis, Hyperplasia, Focal    |                                                                      3   |      3  2.0|
      Pars Distalis, Necrosis, Focal       |                                                                      3   |      1  3.0|
      Rathke's Cleft, Cyst                 |                         3                       1                        |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +|  46        |
      C-Cell, Hyperplasia                  | 1  1  2  2  2  2  2  2  2  2  2  2  3  1  2  3  2     2  2     2  1  2  3|     44  1.9|
      Follicular Cell, Hyperplasia, Cystic,|                                                                          |            |
           Focal                           |                2                                1                        |      5  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |                                     +                                    |   2        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 3| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 2| 3| 3| 0| 3| 5| 0| 3| 3| 5| 3|            |
                                           | 0| 0| 6| 0| 0| 0| 0| 4| 2| 2| 0| 2| 2| 2| 2| 0| 0| 5| 5| 4| 2| 2| 2| 3| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/L                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
   Tissue NOS                              |                         +                                                |   3        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                                                      3   |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                                                    3                     |      1  3.0|
      Hyperplasia, Cystic                  |                            4                                             |      2  3.5|
      Inflammation, Chronic                | 1  2           2     2           2  1  1  2  1  1     2     2  2  1  2  2|     32  1.7|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                | 2  2  3     3  1     2  2  2  3     3     2  1     2           2     1  2|     29  2.2|
      Epithelium, Hyperplasia, Focal       | 2  1  2     1        1        1     2  1  1  2        1        1     1  2|     25  1.4|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                      3                                      3            |      5  3.0|
      Necrosis                             |                                                                      4   |      1  4.0|
      Artery, Thrombosis, Focal            |                                                                      3   |      1  3.0|
      Bilateral, Atrophy                   |                               2                                          |      1  2.0|
      Interstitial Cell, Hyperplasia, Focal|                               2                          2               |      3  1.7|
      Tunic, Inflammation, Chronic         |                                                                      3   |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      2  3.5|
      Myeloid Cell, Hyperplasia            |                                        2                                 |      2  2.5|
      Myeloid Cell, Erythroid Cell,        |                                                                          |            |
          Hyperplasia                      |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 3| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 2| 3| 3| 0| 3| 5| 0| 3| 3| 5| 3|            |
                                           | 0| 0| 6| 0| 0| 0| 0| 4| 2| 2| 0| 2| 2| 2| 2| 0| 0| 5| 5| 4| 2| 2| 2| 3| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/L                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Lymph Node                              | +              +     +  +  +     +  +     +  +           +  +  +     +  +|  25        |
      Mediastinal, Angiectasis             |                                                          3               |      2  3.5|
      Mediastinal, Ectasia                 |                                  3                             3        3|      3  3.0|
      Mediastinal, Hyperplasia, Histiocytic|                                     3                    3               |      2  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                3                                                         |      1  3.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                         3|      1  3.0|
      Mediastinal, Inflammation            |                                                                          |      1  4.0|
      Pancreatic, Ectasia                  |                3                    3        3                           |      3  3.0|
      Pancreatic, Hemorrhage               |                                                                          |      1  3.0|
      Pancreatic, Hyperplasia, Histiocytic | 3                                                                        |      3  3.0|
      Pancreatic, Pigmentation             |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  A  M  M  M  M  M  M  M|            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  48        |
      Accessory Spleen                     |                                                                          |      1     |
      Angiectasis, Focal                   |                                                                          |      1  2.0|
      Fibrosis, Focal                      |                                              2                           |      4  2.5|
      Hematopoietic Cell Proliferation     |                                                          2               |      6  2.2|
      Hemorrhage, Chronic                  |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Infarct                              |                                                                      3   |      2  3.0|
      Artery, Thrombosis                   |                                                                      4   |      1  4.0|
      Capsule, Fibrosis, Focal             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  M  +  +  M  +|  44        |
      Dilatation                           |       2     4        2     2  2     3                                    |      8  2.4|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 3| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 2| 3| 3| 0| 3| 5| 0| 3| 3| 5| 3|            |
                                           | 0| 0| 6| 0| 0| 0| 0| 4| 2| 2| 0| 2| 2| 2| 2| 0| 0| 5| 5| 4| 2| 2| 2| 3| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/L                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
      Hyperplasia                          |             2              2                                             |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Angiectasis,    |                                                                          |            |
           Focal                           |                                     2                                    |      1  2.0|
      Subcutaneous Tissue, Cyst, Chronic   |                                                                          |      1  4.0|
      Subcutaneous Tissue, Edema           |                                                                          |      1  3.0|
      Subcutaneous Tissue, Hemorrhage,     |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Subcutaneous Tissue, Metaplasia,     |                                                                          |            |
           Focal, Osseous                  |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                         +                                +               |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression, Focal                   |       3     2              3  3     3                                    |      6  2.5|
      Hemorrhage, Focal                    |                                           1                              |      2  1.5|
      Necrosis, Focal                      |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |       +                                                                  |   3        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |       +                                                                  |   3        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                    3                     |      4  2.8|
      Hemorrhage, Focal                    | 2                                         1                              |      3  1.7|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 3| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 2| 3| 3| 0| 3| 5| 0| 3| 3| 5| 3|            |
                                           | 0| 0| 6| 0| 0| 0| 0| 4| 2| 2| 0| 2| 2| 2| 2| 0| 0| 5| 5| 4| 2| 2| 2| 3| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/L                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Focal, Histiocytic      |                         3                                                |      1  3.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  1.0|
      Infiltration Cellular, Mixed Cell    |    1                                   2                                 |      2  1.5|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           | 2                    2           2     2        1                        |      7  1.7|
      Interstitium, Edema                  |                                                    3                     |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                2         |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Pleura                                  |                                     +                                    |   1        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                      +                                                   |   1        |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cataract                             |             3  3                                                         |      2  3.0|
      Retina, Degeneration                 |             3  3                                                         |      3  3.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                                        2                                 |      1  2.0|
      Inflammation, Chronic, Focal         |                                                 1                        |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                      +                                                   |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  49        |
      Nephropathy                          | 2  2  2  3  2  2  2  2  1  3  2  3  3  2  3  2  2     2  1  2  2  2  2  3|     49  2.1|
      Renal Tubule, Pigmentation           |                      3                    3              1               |     10  2.1|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 3| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 2| 3| 3| 0| 3| 5| 0| 3| 3| 5| 3|            |
                                           | 0| 0| 6| 0| 0| 0| 0| 4| 2| 2| 0| 2| 2| 2| 2| 0| 0| 5| 5| 4| 2| 2| 2| 3| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/L                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 5| 7| 7| 6| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 9| 3| 3| 2| 3| 3| 2| 5| 2| 3| 3| 6| 0| 5| 3| 3| 9| 9| 3| 3| 3| 2|             
                                           | 2| 1| 2| 8| 5| 5| 6| 1| 1| 9| 4| 9| 5| 5| 1| 9| 6| 5| 5| 7| 7| 1| 1| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    175 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                            2                                             |             
      Basophilic Focus                     | X  X  X     X  X  X     X  X        X  X           X  X        X  X      |             
      Cholangiofibrosis                    |                            2           2                                 |             
      Clear Cell Focus                     | X  X  X     X  X  X     X  X        X  X           X           X  X      |             
      Congestion                           |                                        2                                 |             
      Degeneration, Cystic, Focal          | 2     2     2  2        2  1  2        2  1     2  2  1           1     2|             
      Eosinophilic Focus                   |                      X                                                   |             
      Fibrosis, Focal                      |                                        2                                 |             
      Hepatodiaphragmatic Nodule           |    3  2                                1                                 |             
      Infiltration Cellular, Mixed Cell    | 1  2     1  1  2  2     2  1  2     2  2  2     2  1  2        2  2     2|             
      Inflammation, Chronic                | 1  1  1  1  2  2  1     1  2  1     1  1        2  1  1        1  1      |             
      Mixed Cell Focus                     |                                                       X        X         |             
      Bile Duct, Hyperplasia               | 3  3  3  2  1  3  2  3  3  3  2  3  3  3  2  3  2  3  3  3  3  3  3  3  2|             
      Hepatocyte, Fatty Change             | 1  1  1  2  1  1           1  3     1        2     1  1  1     1  2  1  2|             
      Hepatocyte, Hypertrophy              |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|                                              2           2               |             
      Hepatocyte, Centrilobular, Necrosis  |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                         +        +     +           +     +  +            |             
      Fat, Necrosis, Focal                 |                         3                          3                     |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |          +                                                               |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 5| 7| 7| 6| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 9| 3| 3| 2| 3| 3| 2| 5| 2| 3| 3| 6| 0| 5| 3| 3| 9| 9| 3| 3| 3| 2|             
                                           | 2| 1| 2| 8| 5| 5| 6| 1| 1| 9| 4| 9| 5| 5| 1| 9| 6| 5| 5| 7| 7| 1| 1| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    175 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               |    1        2  1              1           1              2     1  2     1|             
      Duct, Cyst, Focal, Multiple          |             2                    2           1                 1        1|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                         3|             
      Inflammation, Focal                  |                                                                          |             
      Ulcer                                |                                                                         2|             
      Epithelium, Hyperplasia              |                                              2                           |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion                              |                                                                          |             
      Infarct                              |                                              2                           |             
      Inflammation, Focal                  |                                                                          |             
      Pigmentation, Focal                  |                                                                          |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Glands, Ectasia, Focal               |          1                                                               |             
      Glands, Necrosis, Focal              |                                                                          |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                   +                                                      |             
      Infiltration Cellular, Focal, Mixed  |                                                                          |             
          Cell                             |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Epithelium Alveolus, Hyperplasia     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2        2  3  1                 2  1     2     2           3         |             
      Thrombosis                           |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 5| 7| 7| 6| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 9| 3| 3| 2| 3| 3| 2| 5| 2| 3| 3| 6| 0| 5| 3| 3| 9| 9| 3| 3| 3| 2|             
                                           | 2| 1| 2| 8| 5| 5| 6| 1| 1| 9| 4| 9| 5| 5| 1| 9| 6| 5| 5| 7| 7| 1| 1| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    175 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |       1     1  1                                                     1   |             
      Cytoplasmic Alteration, Focal        |          2                                                               |             
      Infiltration Cellular, Mixed Cell    |                         2                                                |             
      Vacuolization Cytoplasmic, Focal     |                      1     1                       1                     |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |    1  1           1              1     1     1     1           1        3|             
      Bilateral, Hyperplasia, Focal        |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2                       2                                 |             
      Pars Distalis, Cyst                  |                                                             3            |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |    1                             1                                       |             
      Pars Distalis, Hemorrhage, Focal     |                            1  2                                2         |             
      Pars Distalis, Hyperplasia, Focal    |                                        2                       2         |             
      Pars Intermedia, Cyst                |                                                                          |             
      Rathke's Cleft, Cyst                 |                      2                                                   |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1  2  2  2  1  2  2  2  2  2  3  2  1  2  3  1  1  2  1  1  2  1  1  2   |             
      Follicle, Degeneration, Cystic, Focal| 2           2                                                            |             
      Follicular Cell, Hyperplasia, Cystic,|                                                                          |             
           Focal                           |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                                  +                                       |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                                             +        +  +|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 5| 7| 7| 6| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 9| 3| 3| 2| 3| 3| 2| 5| 2| 3| 3| 6| 0| 5| 3| 3| 9| 9| 3| 3| 3| 2|             
                                           | 2| 1| 2| 8| 5| 5| 6| 1| 1| 9| 4| 9| 5| 5| 1| 9| 6| 5| 5| 7| 7| 1| 1| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    175 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
      Inflammation, Chronic                |    2  1     1  2  1     1     2  2     1           1  1  1  2  2  1     2|             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 3           2  3  3  1  1  1  1  1  3     2     2  3  3        1  1  2   |             
      Epithelium, Hyperplasia, Focal       | 1  1        1  2     1        2     2     2        1  2        2         |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         3                 2  3                          2|             
      Bilateral, Interstitial Cell,        |                                                                          |             
          Hyperplasia, Focal               |                                                                         1|             
      Interstitial Cell, Hyperplasia, Focal|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Hyperplasia, Focal, Histiocytic      |                   1                                                      |             
      Hyperplasia, Histiocytic             |                                                       4                  |             
      Hyperplasia                          |                                                                          |             
      Myeloid Cell, Erythroid Cell,        |                                                                          |             
          Hyperplasia                      |                                           3     3                       2|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |       +     +        +  +        +              +     +  +  +     +  +  +|             
      Bronchial, Hyperplasia, Plasma Cell  |                                                                          |             
      Mediastinal, Ectasia                 |                                                                   3      |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Hyperplasia             |                                                       3                  |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                 3        4               |             
      Pancreatic, Ectasia                  |             3                                   3                       3|             
      Pancreatic, Hyperplasia, Histiocytic |             3                                         3           3      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 5| 7| 7| 6| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 9| 3| 3| 2| 3| 3| 2| 5| 2| 3| 3| 6| 0| 5| 3| 3| 9| 9| 3| 3| 3| 2|             
                                           | 2| 1| 2| 8| 5| 5| 6| 1| 1| 9| 4| 9| 5| 5| 1| 9| 6| 5| 5| 7| 7| 1| 1| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    175 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Histiocytic             | 3     3                                                                  |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Congestion                           | 3                                                                        |             
      Fibrosis, Focal                      |                            2                                             |             
      Hematopoietic Cell Proliferation     |                   2           2           2           2                 3|             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
      Infarct                              |                                              3                           |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  M  +  +  +|             
      Dilatation                           |                         1                          3  2              2  2|             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          |                                                    3                     |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Angiectasis,    |                                                                          |             
           Focal                           |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |                                                       3                  |             
      Hemorrhage, Focal                    |          3                                                               |             
      Necrosis, Focal                      |                                                                          |             
      Cerebrum, Ventricle, Hydrocephalus   |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 5| 7| 7| 6| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 9| 3| 3| 2| 3| 3| 2| 5| 2| 3| 3| 6| 0| 5| 3| 3| 9| 9| 3| 3| 3| 2|             
                                           | 2| 1| 2| 8| 5| 5| 6| 1| 1| 9| 4| 9| 5| 5| 1| 9| 6| 5| 5| 7| 7| 1| 1| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    175 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |    2                                                                     |             
      Hemorrhage, Focal                    |                                                                          |             
      Hemorrhage                           |          3                                                               |             
      Hyperplasia, Focal, Histiocytic      |                                                                1         |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                      1   |             
      Metaplasia, Squamous                 |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                     1  2                 2               |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |          3                                                               |             
      Inflammation, Suppurative            |                            2                                             |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                              4                           |             
      Nephropathy                          | 2  2  2  2  2  3  1  1  2  2  2  2  2  2  1  1  2  1  2  1  2  2  2  2  2|             
      Artery, Thrombosis                   |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 5| 7| 7| 6| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 5| 3| 9| 3| 3| 2| 3| 3| 2| 5| 2| 3| 3| 6| 0| 5| 3| 3| 9| 9| 3| 3| 3| 2|             
                                           | 2| 1| 2| 8| 5| 5| 6| 1| 1| 9| 4| 9| 5| 5| 1| 9| 6| 5| 5| 7| 7| 1| 1| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    175 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Renal Tubule, Pigmentation           |          2           2  2        3           3     2  2              2   |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 0| 3| 3| 3| 3| 3| 2| 2| 9| 6| 3| 6| 6| 8| 2| 8| 0| 9| 3| 3| 3| 3| 3|            |
                                           | 9| 0| 5| 1| 1| 2| 2| 2| 0| 9| 7| 7| 0| 7| 0| 3| 4| 1| 9| 5| 5| 5| 5| 2| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    175 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |             2  2                                      2                  |      4  2.0|
      Basophilic Focus                     |    X     X        X  X              X  X     X              X  X  X  X   |     25     |
      Cholangiofibrosis                    |                                                                          |      2  2.0|
      Clear Cell Focus                     |    X     X  X  X  X  X              X                       X  X  X  X   |     24     |
      Congestion                           |                                                                          |      1  2.0|
      Degeneration, Cystic, Focal          |    2     2  2  2  2  1              1           2     2              3   |     24  1.8|
      Eosinophilic Focus                   |                                                                          |      1     |
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                 3        3               |      5  2.4|
      Infiltration Cellular, Mixed Cell    |    2     2     2  2  2              2  2        2     2     2  2  2  2   |     31  1.8|
      Inflammation, Chronic                |    1     2     2  1  1                 1     2  1           1  1  1  3   |     29  1.3|
      Mixed Cell Focus                     |                                                                         X|      3     |
      Bile Duct, Hyperplasia               | 2  3  3     3  3  3  3  2  3  3  3  3  2  3  2  3  3  3  3  2  3  3  3  3|     49  2.7|
      Hepatocyte, Fatty Change             | 2  1  1        2  2     3     1  1  1     2  1     1  2     1  1  1     1|     34  1.4|
      Hepatocyte, Hypertrophy              |                                                    3                     |      1  3.0|
      Hepatocyte, Vacuolization Cytoplasmic|       1        1  2           3  2        3        3                    1|     10  2.0|
      Hepatocyte, Centrilobular, Necrosis  |                                                    2                     |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 0| 3| 3| 3| 3| 3| 2| 2| 9| 6| 3| 6| 6| 8| 2| 8| 0| 9| 3| 3| 3| 3| 3|            |
                                           | 9| 0| 5| 1| 1| 2| 2| 2| 0| 9| 7| 7| 0| 7| 0| 3| 4| 1| 9| 5| 5| 5| 5| 2| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    175 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Mesentery                               |       +              +        +  +                 +     +  +            |  13        |
      Fat, Necrosis, Focal                 |                      3                                      3            |      4  3.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                            +                                             |   2        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy, Focal               |             2        2  2  2  1           2     3     2     2        2  3|     20  1.8|
      Duct, Cyst, Focal, Multiple          |    2     1  1                 2     1                    2  1     2  1   |     14  1.4|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                           3                              |      2  3.0|
      Inflammation, Focal                  | 2                                                     3                  |      2  2.5|
      Ulcer                                |                         3                 3           3                  |      4  2.8|
      Epithelium, Hyperplasia              | 2                       3                 2           3                  |      5  2.4|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                           2                              |      1  2.0|
      Erosion                              |       3                 2                 1        2                     |      4  2.0|
      Infarct                              |                                                                          |      1  2.0|
      Inflammation, Focal                  |                         3                                                |      1  3.0|
      Pigmentation, Focal                  |       3                                                                  |      1  3.0|
      Artery, Inflammation, Chronic        |                         3                                                |      1  3.0|
      Glands, Ectasia, Focal               |                                                                          |      1  1.0|
      Glands, Necrosis, Focal              |                                           2                              |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Infiltration Cellular, Focal, Mixed  |                                                                          |            |
          Cell                             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                            +                                             |   1        |
      Epithelium Alveolus, Hyperplasia     |                            3                                             |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 0| 3| 3| 3| 3| 3| 2| 2| 9| 6| 3| 6| 6| 8| 2| 8| 0| 9| 3| 3| 3| 3| 3|            |
                                           | 9| 0| 5| 1| 1| 2| 2| 2| 0| 9| 7| 7| 0| 7| 0| 3| 4| 1| 9| 5| 5| 5| 5| 2| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    175 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    2  2                                2              1  2  1  1     2   |     18  1.8|
      Thrombosis                           |                                                    4                     |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                      1                    1  1        2                  |      8  1.1|
      Cytoplasmic Alteration, Focal        |                                        1                                2|      3  1.7|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |                                     1        1                           |      5  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   | 1              3  4        1  2                       2        4        1|     17  1.7|
      Bilateral, Hyperplasia, Focal        |                                           4                              |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                      2   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      2  2.0|
      Pars Distalis, Cyst                  |                               2                                          |      2  2.5|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                1        2                 1                       1      |      6  1.2|
      Pars Distalis, Hemorrhage, Focal     |                                  3        2                              |      5  2.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      2  2.0|
      Pars Intermedia, Cyst                |       1                                                                  |      1  1.0|
      Rathke's Cleft, Cyst                 |             3                                                            |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +|  48        |
      C-Cell, Hyperplasia                  | 2  2  1  3  1  1  1  1  2  2  1  2  2  2     2  1     2     2  1  1  1  1|     46  1.6|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 0| 3| 3| 3| 3| 3| 2| 2| 9| 6| 3| 6| 6| 8| 2| 8| 0| 9| 3| 3| 3| 3| 3|            |
                                           | 9| 0| 5| 1| 1| 2| 2| 2| 0| 9| 7| 7| 0| 7| 0| 3| 4| 1| 9| 5| 5| 5| 5| 2| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    175 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Follicle, Degeneration, Cystic, Focal|                                                                          |      2  2.0|
      Follicular Cell, Hyperplasia, Cystic,|                                                                          |            |
           Focal                           |                      2                                      1  2         |      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |                                                    +                     |   2        |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              | +                                                                        |   4        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  |                            3                                             |      1  3.0|
      Inflammation, Chronic                | 1                 1  2     3  1              1  1  1     2  1  1  2  2  1|     30  1.4|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                | 3  3           1     3  2     1  1  3  3  1  2  3  1           3     1  3|     33  2.0|
      Epithelium, Hyperplasia, Focal       |                1           2     1  2     1  2  2           1  1        4|     21  1.6|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                            3     3                          3  3         |      8  2.8|
      Bilateral, Interstitial Cell,        |                                                                          |            |
          Hyperplasia, Focal               |                                                                          |      1  1.0|
      Interstitial Cell, Hyperplasia, Focal|                                              1                           |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +     +  +  +  +  +  A  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
      Hyperplasia, Focal, Histiocytic      |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 0| 3| 3| 3| 3| 3| 2| 2| 9| 6| 3| 6| 6| 8| 2| 8| 0| 9| 3| 3| 3| 3| 3|            |
                                           | 9| 0| 5| 1| 1| 2| 2| 2| 0| 9| 7| 7| 0| 7| 0| 3| 4| 1| 9| 5| 5| 5| 5| 2| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    175 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hyperplasia, Histiocytic             |                                                                          |      1  4.0|
      Hyperplasia                          | 3                                                                       4|      2  3.5|
      Myeloid Cell, Erythroid Cell,        |                                                                          |            |
          Hyperplasia                      |                                                    3        3            |      5  2.8|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +  +  +     +  +        +  +  +  +  +     +           +  +  +        +  +|  28        |
      Bronchial, Hyperplasia, Plasma Cell  |                                     3                                    |      1  3.0|
      Mediastinal, Ectasia                 |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                             3            |      1  3.0|
      Mediastinal, Hyperplasia             |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Plasma Cell|                            3                                             |      3  3.3|
      Pancreatic, Ectasia                  |                                                       3     3            |      5  3.0|
      Pancreatic, Hyperplasia, Histiocytic |    2           3                    2                                3   |      7  2.7|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  +  M  +  M  M  M|   3        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Ectasia                              |                      3                                                   |      1  3.0|
      Hyperplasia, Histiocytic             |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Angiectasis, Focal                   |                               3                                         3|      2  3.0|
      Congestion                           |                                                                          |      1  3.0|
      Fibrosis, Focal                      |                               3                                         3|      3  2.7|
      Hematopoietic Cell Proliferation     |                                                    3        2            |      7  2.3|
      Hyperplasia, Focal, Histiocytic      |                                                                      4   |      1  4.0|
      Infarct                              |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Dilatation                           | 4                 3              3  2  3  2  2  3  2  1     2  4     2   |     18  2.4|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 0| 3| 3| 3| 3| 3| 2| 2| 9| 6| 3| 6| 6| 8| 2| 8| 0| 9| 3| 3| 3| 3| 3|            |
                                           | 9| 0| 5| 1| 1| 2| 2| 2| 0| 9| 7| 7| 0| 7| 0| 3| 4| 1| 9| 5| 5| 5| 5| 2| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    175 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
      Fibrosis                             |                   2                                                      |      1  2.0|
      Hyperplasia                          |                      2                                         3         |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Angiectasis,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |                                     2                                    |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression, Focal                   | 3                                   2  3     3  3     3  3               |      8  2.9|
      Hemorrhage, Focal                    |       3                 3     2                                          |      4  2.8|
      Necrosis, Focal                      |       3                 3                                                |      2  3.0|
      Cerebrum, Ventricle, Hydrocephalus   |    3                                                                     |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                 +                        |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                 +                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  2.0|
      Hemorrhage, Focal                    |                                                 2                        |      1  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Focal, Histiocytic      |                                                                          |      1  1.0|
      Hyperplasia, Histiocytic             |                         1                                                |      1  1.0|
      Inflammation, Chronic, Focal         |                                                             2            |      2  1.5|
      Metaplasia, Squamous                 |                                                    4                     |      1  4.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 6| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 0| 3| 3| 3| 3| 3| 2| 2| 9| 6| 3| 6| 6| 8| 2| 8| 0| 9| 3| 3| 3| 3| 3|            |
                                           | 9| 0| 5| 1| 1| 2| 2| 2| 0| 9| 7| 7| 0| 7| 0| 3| 4| 1| 9| 5| 5| 5| 5| 2| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    175 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                              1     2        2            |      6  1.7|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Suppurative            | 2                                                                    2   |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cataract                             |             3                                                            |      1  3.0|
      Retina, Degeneration                 |             3                                                            |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |                                  4        2                              |      3  3.3|
      Nephropathy                          | 2  2  1  2  2  2  2  1  2  1  2  1  2  2  2  2  1  2  2  1  2  2  2  2  2|     50  1.8|
      Artery, Thrombosis                   |                                  3                                       |      1  3.0|
      Renal Tubule, Pigmentation           |                         1  2     2                 3           2         |     13  2.2|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |       3                                                                  |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 3| 3| 9| 3| 3| 3| 4| 3| 3| 3| 0| 2| 3| 0| 6| 3| 2| 2| 3| 2| 3| 3| 4| 2|             
                                           | 6| 0| 0| 7| 1| 1| 0| 2| 0| 0| 0| 5| 7| 5| 3| 9| 2| 1| 9| 0| 8| 1| 1| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    350 MG/L                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  A  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  A  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  A  A  +  +  A  +|             
      Edema                                |          2                                                               |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  A  +  +  A  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  A  +  +  A  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |             2  2                          2           2                  |             
      Basophilic Focus                     |             X     X  X  X  X  X     X     X     X  X  X        X        X|             
      Cholangiofibrosis                    | 3                                                                        |             
      Clear Cell Focus                     |    X        X     X     X     X        X        X     X                 X|             
      Congestion                           |                                           3                              |             
      Degeneration, Cystic, Focal          |       2     2  2     2     1  2     2        2  2     1     2           2|             
      Eosinophilic Focus                   |                               X                       X                  |             
      Fibrosis, Focal                      |                            2                                             |             
      Hepatodiaphragmatic Nodule           |                      3  3  2                       1     3        3  2  3|             
      Hyperplasia, Focal, Histiocytic      |                      2                                                   |             
      Infiltration Cellular, Mixed Cell    | 3  2              2  2     2  2     2  2     2  2     2  2  2  2     1   |             
      Inflammation, Chronic                | 1  1  1     2     2     1  1  1     1  1     1  1           1  2        1|             
      Mixed Cell Focus                     |       X                    X        X                 X                  |             
      Tension Lipidosis                    |                      3                                                   |             
      Bile Duct, Hyperplasia               | 3  3  3  3  3  3  3  3  3  3  3  3  3  2  3  2  3  3  2  2  2  2  3  3  3|             
      Hepatocyte, Fatty Change             |    2        1  1  1  1  1  1  1  1  2  1  2  2  1     2     2     1  4  1|             
      Hepatocyte, Vacuolization Cytoplasmic| 1  1        2           1                                      1  2     2|             
      Hepatocyte, Centrilobular, Necrosis  | 3                                                                        |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +        +  +                    +     +        +                        |             
      Inflammation, Chronic                |             2                                                            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 3| 3| 9| 3| 3| 3| 4| 3| 3| 3| 0| 2| 3| 0| 6| 3| 2| 2| 3| 2| 3| 3| 4| 2|             
                                           | 6| 0| 0| 7| 1| 1| 0| 2| 0| 0| 0| 5| 7| 5| 3| 9| 2| 1| 9| 0| 8| 1| 1| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    350 MG/L                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Fat, Necrosis, Focal                 |          3  3                    3     3                                 |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                              +                           |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Acinus, Atrophy, Focal               |       2  3  2  3  2     2  2  2     2  3     2  2  1  2           1      |             
      Duct, Cyst, Focal, Multiple          |    1     2  1     2        2  1     2        2  2  1  2                  |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |          3                          3                                    |             
      Inflammation, Chronic, Diffuse       |                                     3                                    |             
      Inflammation, Diffuse                |                                                                      2   |             
      Inflammation, Focal                  |          3                                                               |             
      Ulcer                                |          2           1                                                   |             
      Epithelium, Hyperplasia              |          3           2              3                                3   |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular, Focal               |                                                                          |             
      Erosion                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                     +                                    |             
      Epithelium, Hyperplasia, Focal       |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                1  1                       2        2  2     2  2     2  2|             
      Fibrosis, Focal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |    2              1                    3     1        1     1            |             
      Angiectasis                          |                                                       2                  |             
      Cytoplasmic Alteration, Focal        |       2                                                                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 3| 3| 9| 3| 3| 3| 4| 3| 3| 3| 0| 2| 3| 0| 6| 3| 2| 2| 3| 2| 3| 3| 4| 2|             
                                           | 6| 0| 0| 7| 1| 1| 0| 2| 0| 0| 0| 5| 7| 5| 3| 9| 2| 1| 9| 0| 8| 1| 1| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    350 MG/L                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Necrosis, Focal                      |                                                                   3      |             
      Vacuolization Cytoplasmic, Focal     |          1           2              1     2                    1         |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                           4                              |             
      Hyperplasia, Focal                   |    1     2     1  1        1     1                                      1|             
      Necrosis, Focal                      |                                                                   2      |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        2                                 |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                   2      |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |                                                                          |             
      Pars Distalis, Hemorrhage, Focal     |                3                                                         |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
      Rathke's Cleft, Hemorrhage           |          2                                                               |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  A  +  +  A  +|             
      Hemorrhage                           |                                                          2               |             
      C-Cell, Hyperplasia                  | 2  2  2  1  1  1  1  2  2  1  2  1  2  1     2  1              1  2     1|             
      Follicular Cell, Hyperplasia, Cystic,|                                                                          |             
           Focal                           |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              | +                                               +                        |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 3| 3| 9| 3| 3| 3| 4| 3| 3| 3| 0| 2| 3| 0| 6| 3| 2| 2| 3| 2| 3| 3| 4| 2|             
                                           | 6| 0| 0| 7| 1| 1| 0| 2| 0| 0| 0| 5| 7| 5| 3| 9| 2| 1| 9| 0| 8| 1| 1| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    350 MG/L                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia, Cystic                  |       2                                                                  |             
      Inflammation, Chronic                | 2  2     1  1  1              1  1              2     2     1  2  2     2|             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2  1  3     3     2  3     3  2     3  2  3     2     2  2  4     1  3  2|             
      Epithelium, Hyperplasia, Focal       | 2     1     1  1           1  2        1  1     2     1           2      |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                               3                                          |             
      Inflammation, Chronic                |                                                             3            |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3        3              3                    3                          3|             
      Bilateral, Atrophy                   |                                                                          |             
      Interstitial Cell, Hyperplasia, Focal|                                           1                              |             
      Interstitial Cell, Hyperplasia       |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Hyperplasia                          |                         3                          2              3      |             
      Myeloid Cell, Hyperplasia            | 3                                                                        |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +     +  +  +  +  +           +  +  +              +  +        +  +      |             
      Mediastinal, Ectasia                 |                                                                3         |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                               3                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|          3                                            3                  |             
      Pancreatic, Ectasia                  |                                     3                             3      |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Pancreatic, Pigmentation             |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  34                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 3| 3| 9| 3| 3| 3| 4| 3| 3| 3| 0| 2| 3| 0| 6| 3| 2| 2| 3| 2| 3| 3| 4| 2|             
                                           | 6| 0| 0| 7| 1| 1| 0| 2| 0| 0| 0| 5| 7| 5| 3| 9| 2| 1| 9| 0| 8| 1| 1| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    350 MG/L                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Accessory Spleen                     |                            X                                             |             
      Congestion                           |          2                                                               |             
      Fibrosis, Focal                      |          3                                                               |             
      Hematopoietic Cell Proliferation     | 3                                            2              2            |             
      Infarct                              |                3                                                         |             
      Pigmentation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular, Focal               |                                                                          |             
      Dilatation                           |          2           3     3        3  1  3                    2     2   |             
      Ectasia                              |                                                          2               |             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                                          |             
      Mineralization, Focal                |                      3                                                   |             
      Subcutaneous Tissue, Cyst Epithelial |                                                                          |             
          Inclusion                        |                                                                          |             
      Subcutaneous Tissue, Hemorrhage,     |                                                                          |             
           Focal                           |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Focal, Granulomatous            |                                                                          |             
      Subcutaneous Tissue, Epidermis,      |                                                                          |             
          Hyperplasia, Focal               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  35                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 3| 3| 9| 3| 3| 3| 4| 3| 3| 3| 0| 2| 3| 0| 6| 3| 2| 2| 3| 2| 3| 3| 4| 2|             
                                           | 6| 0| 0| 7| 1| 1| 0| 2| 0| 0| 0| 5| 7| 5| 3| 9| 2| 1| 9| 0| 8| 1| 1| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    350 MG/L                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |                      3     3        3     3              3     3        3|             
      Hemorrhage, Focal                    |                                                                          |             
      Hydrocephalus                        |                      3                                                   |             
      Cerebellum, Hemorrhage, Focal        |                                                                          |             
      Pineal Gland, Vacuolization          |                                                                          |             
          Cytoplasmic                      |                                                          3               |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                  +  +                                    |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                  +  +                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                           3                              |             
      Hemorrhage, Focal                    |                                                                   1      |             
      Inflammation, Chronic, Focal         |          2                                                               |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |          2                    1                                      2   |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Nasolacrimal Duct, Inflammation      |                         3                                                |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|             
      Cataract                             |                                  3  2                          3         |             
      Inflammation, Chronic                |                                              3                           |             
      Retina, Degeneration                 |                                  3  2        4                 3         |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  36                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 3| 3| 9| 3| 3| 3| 4| 3| 3| 3| 0| 2| 3| 0| 6| 3| 2| 2| 3| 2| 3| 3| 4| 2|             
                                           | 6| 0| 0| 7| 1| 1| 0| 2| 0| 0| 0| 5| 7| 5| 3| 9| 2| 1| 9| 0| 8| 1| 1| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    350 MG/L                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
      Hyperplasia, Focal, Histiocytic      |                            2                                             |             
      Hyperplasia, Focal, Lymphoid         |                            2                                             |             
      Inflammation, Chronic, Focal         |                   2                                                      |             
      Epithelium, Hyperplasia, Focal       |                            1                                             |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Metaplasia, Focal, Osseous           |                                                       2                  |             
      Nephropathy                          | 2  2  2  3  2  2  2  2  2  2  2  2  2  2  3  2  2  2  2  1  2  2  2  3  2|             
      Pelvis, Dilatation                   |                                                             3            |             
      Renal Tubule, Pigmentation           | 3     2              2     2                                             |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                             3            |             
      Inflammation, Chronic                |                                                             3            |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  37                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 6| 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 4| 3| 9| 0| 6| 2| 0|            |
                                           | 9| 2| 9| 9| 9| 9| 3| 0| 1| 5| 1| 5| 5| 1| 5| 5| 5| 0| 8| 0| 1| 9| 7| 9| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    350 MG/L                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  44        |
      Edema                                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                  2                                       |      5  2.0|
      Basophilic Focus                     | X     X  X           X  X     X     X        X  X              X  X      |     24     |
      Cholangiofibrosis                    |                                                                          |      1  3.0|
      Clear Cell Focus                     | X     X  X           X        X  X        X  X  X  X                     |     19     |
      Congestion                           |                                                                          |      1  3.0|
      Degeneration, Cystic, Focal          |       1  1  1           1        1        2     2        2     2  2     2|     23  1.7|
      Eosinophilic Focus                   |                                  X                             X         |      4     |
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |    3                                         2  2     3                  |     12  2.5|
      Hyperplasia, Focal, Histiocytic      |                                                                          |      1  2.0|
      Infiltration Cellular, Mixed Cell    | 2  2  2  1     1     1  2     2  2  1     1  2  1  1  2  2     2  2     2|     34  1.8|
      Inflammation, Chronic                | 1  2  2  1     1     2  1     2  1  2     2  1  1  2     2     1  1     2|     33  1.4|
      Mixed Cell Focus                     |                X        X           X              X     X        X      |     10     |
      Tension Lipidosis                    |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               | 3  1  3  3  3  3  2  3  3  3  2  2  3  3  3  3  3  2  2     3  3  2  3  3|     49  2.7|
      Hepatocyte, Fatty Change             | 1  3  1  1        4  1     3  2  1        1  1  1  2  1  1  2     1      |     36  1.5|
      Hepatocyte, Vacuolization Cytoplasmic| 1     1  2                 2  1  1        2  2  1  2     2  2            |     19  1.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  38                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 6| 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 4| 3| 9| 0| 6| 2| 0|            |
                                           | 9| 2| 9| 9| 9| 9| 3| 0| 1| 5| 1| 5| 5| 1| 5| 5| 5| 0| 8| 0| 1| 9| 7| 9| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    350 MG/L                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Hepatocyte, Centrilobular, Necrosis  |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                   +        +           +              +     +     +  +  +|  14        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Fat, Necrosis, Focal                 |                   3                                   2           2  2  3|      9  2.7|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |          3                                                               |      1  3.0|
      Acinus, Atrophy, Focal               | 1                 1     2        1  3  1              1           1      |     23  1.8|
      Duct, Cyst, Focal, Multiple          | 1                 2     1        2                    1  1               |     17  1.5|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                   3                                                      |      3  3.0|
      Inflammation, Chronic, Diffuse       |                                                                          |      1  3.0|
      Inflammation, Diffuse                |                   2                                                      |      2  2.0|
      Inflammation, Focal                  |                            2                                             |      2  2.5|
      Ulcer                                |                   3                                         2            |      4  2.0|
      Epithelium, Hyperplasia              |                                                                          |      4  2.8|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atypia Cellular, Focal               |                                              2                           |      1  2.0|
      Erosion                              |                                                             3            |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |       1           2  2  2        1           1  2     2  2        1  2  1|     21  1.7|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  39                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 6| 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 4| 3| 9| 0| 6| 2| 0|            |
                                           | 9| 2| 9| 9| 9| 9| 3| 0| 1| 5| 1| 5| 5| 1| 5| 5| 5| 0| 8| 0| 1| 9| 7| 9| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    350 MG/L                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
      Fibrosis, Focal                      |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                            1                                            1|      8  1.4|
      Angiectasis                          |                                                                          |      1  2.0|
      Cytoplasmic Alteration, Focal        |                   1     2                                                |      3  1.7|
      Necrosis, Focal                      |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic, Focal     |                                                          2        1     1|      8  1.4|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Focal                   | 1     1              2  2  1        2           2                    1   |     15  1.3|
      Necrosis, Focal                      |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  |                                        1                                 |      2  1.5|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |          2                                                               |      1  2.0|
      Pars Distalis, Hemorrhage, Focal     |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia, Focal    |                      2                             2                     |      2  2.0|
      Rathke's Cleft, Hemorrhage           |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +|  44        |
      Hemorrhage                           |                                                                          |      1  2.0|
      C-Cell, Hyperplasia                  | 2  2  2  1  2  1     2  1  2  1  2  2     1  1  2  2     1     2  2  2  1|     40  1.6|
      Follicular Cell, Hyperplasia, Cystic,|                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  40                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 6| 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 4| 3| 9| 0| 6| 2| 0|            |
                                           | 9| 2| 9| 9| 9| 9| 3| 0| 1| 5| 1| 5| 5| 1| 5| 5| 5| 0| 8| 0| 1| 9| 7| 9| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    350 MG/L                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
           Focal                           |             1     2           2                                          |      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   2        |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                                             +            |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                                           3                              |      1  3.0|
      Hyperplasia, Cystic                  |                                                                          |      1  2.0|
      Inflammation, Chronic                | 1     1     2  1     2  1  1  2  1           1  2  2  1  2     1  2  2  2|     31  1.5|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |    3     1  1  2  3     3     2  1  2  1  1     2     3  3     2  2     3|     35  2.2|
      Epithelium, Hyperplasia, Focal       | 2        1  1  1        2  1        2  1  2     3        2        2     2|     24  1.5|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |    3                                   3                 3               |      8  3.0|
      Bilateral, Atrophy                   |                   3                                                      |      1  3.0|
      Interstitial Cell, Hyperplasia, Focal|                2           2                                             |      3  1.7|
      Interstitial Cell, Hyperplasia       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  41                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 6| 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 4| 3| 9| 0| 6| 2| 0|            |
                                           | 9| 2| 9| 9| 9| 9| 3| 0| 1| 5| 1| 5| 5| 1| 5| 5| 5| 0| 8| 0| 1| 9| 7| 9| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    350 MG/L                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hyperplasia                          |             4                                                        4   |      5  3.2|
      Myeloid Cell, Hyperplasia            | 3                                                  2                     |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +  +     +  +  +        +  +        +  +              +     +  +     +   |  26        |
      Mediastinal, Ectasia                 |          3              3                                                |      3  3.0|
      Mediastinal, Hemorrhage              |                3                                                         |      1  3.0|
      Mediastinal, Hyperplasia, Histiocytic|                                                       3                  |      1  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Plasma Cell|             4           3           3                 3                  |      6  3.2|
      Pancreatic, Ectasia                  |                                                                3         |      3  3.0|
      Pancreatic, Hemorrhage               | 3                                   2                                    |      2  2.5|
      Pancreatic, Pigmentation             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   1        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Accessory Spleen                     |                                                                          |      1     |
      Congestion                           |                                                                          |      1  2.0|
      Fibrosis, Focal                      |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                2        2|      5  2.2|
      Infarct                              |                                                                          |      1  3.0|
      Pigmentation                         |                   4                                                      |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                       2                  |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +|  47        |
      Atypia Cellular, Focal               |                2                                                         |      1  2.0|
      Dilatation                           |    2           4  4     3           1           2     2           2      |     16  2.4|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  42                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 6| 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 4| 3| 9| 0| 6| 2| 0|            |
                                           | 9| 2| 9| 9| 9| 9| 3| 0| 1| 5| 1| 5| 5| 1| 5| 5| 5| 0| 8| 0| 1| 9| 7| 9| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    350 MG/L                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
      Ectasia                              |                                                                          |      1  2.0|
      Hyperplasia                          |                                                          2           2   |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic, Focal         |                3                                                         |      1  3.0|
      Mineralization, Focal                |                                                                          |      1  3.0|
      Subcutaneous Tissue, Cyst Epithelial |                                                                          |            |
          Inclusion                        |          2                                                               |      1  2.0|
      Subcutaneous Tissue, Hemorrhage,     |                                                                          |            |
           Focal                           |          3                                                               |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Focal, Granulomatous            |          2                                                               |      1  2.0|
      Subcutaneous Tissue, Epidermis,      |                                                                          |            |
          Hyperplasia, Focal               |          2                                                               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression, Focal                   |    3           3  3     3           3                 4  3               |     14  3.1|
      Hemorrhage, Focal                    |                            3                                             |      1  3.0|
      Hydrocephalus                        |                   3                                                      |      2  3.0|
      Cerebellum, Hemorrhage, Focal        |                         1                                                |      1  1.0|
      Pineal Gland, Vacuolization          |                                                                          |            |
          Cytoplasmic                      |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |    +                                               +                     |   4        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |    +                                               +                     |   4        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  43                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 6| 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 4| 3| 9| 0| 6| 2| 0|            |
                                           | 9| 2| 9| 9| 9| 9| 3| 0| 1| 5| 1| 5| 5| 1| 5| 5| 5| 0| 8| 0| 1| 9| 7| 9| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    350 MG/L                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                 3     3                  |      3  3.0|
      Hemorrhage, Focal                    |                         2                                                |      2  1.5|
      Inflammation, Chronic, Focal         |                                                          2              1|      3  1.7|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           | 1                       2           1              1     2              1|      9  1.4|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                         1           2              2                     |      3  1.7|
      Nasolacrimal Duct, Inflammation      |    2                                                                    2|      3  2.3|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                                 +                        |   1        |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cataract                             | 3                                                  3           3        3|      7  2.9|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Retina, Degeneration                 | 3                                                  3           3        1|      8  2.8|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal, Histiocytic      |                                                                          |      1  2.0|
      Hyperplasia, Focal, Lymphoid         |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  44                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 6| 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 4| 3| 9| 0| 6| 2| 0|            |
                                           | 9| 2| 9| 9| 9| 9| 3| 0| 1| 5| 1| 5| 5| 1| 5| 5| 5| 0| 8| 0| 1| 9| 7| 9| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    350 MG/L                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Infarct                              |                            3                                             |      1  3.0|
      Metaplasia, Focal, Osseous           |                                                                          |      1  2.0|
      Nephropathy                          | 2  2  2  1  2  1  3  2  2  1  2  2  2  1  2  2  2  2  2  3     2  2  2  2|     49  2.0|
      Pelvis, Dilatation                   |                                                                          |      1  3.0|
      Renal Tubule, Pigmentation           |                                        3                 2           2   |      7  2.3|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  45                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 6| 7| 6| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 0| 3| 2| 2| 4| 0| 3| 3| 3| 0| 3| 3| 4| 9| 1| 3| 8| 2| 9| 2| 3| 3| 7| 3|             
                                           | 6| 9| 7| 9| 9| 2| 9| 1| 1| 1| 9| 1| 1| 8| 5| 9| 1| 6| 9| 3| 9| 1| 1| 2| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    700 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  A  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  A  +  +  +  +  +  A  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                     1                                2   |             
      Basophilic Focus                     |          X        X  X  X  X     X  X                       X           X|             
      Cholangiofibrosis                    |                                  2                                       |             
      Clear Cell Focus                     |       X  X  X     X     X           X                 X     X  X  X     X|             
      Congestion                           |    3                                      3                          3   |             
      Degeneration, Cystic, Focal          |       2  2  2     1  1  1  2  2  2  2        1        1           2  2  2|             
      Fibrosis, Focal                      |       3                          3                                       |             
      Hemorrhage, Focal                    |                                                                          |             
      Hepatodiaphragmatic Nodule           |                      3                                                   |             
      Hyperplasia, Focal, Regenerative     |       4                                                                  |             
      Infiltration Cellular, Mixed Cell    |    2  2  2  2     2  2  2  2  2  2  1  2  2     2  2           2     2  2|             
      Inflammation, Chronic                |    2  2  2  1     2  1  1  2     1  1  1        1     1     2     1  1   |             
      Mixed Cell Focus                     |                                  X                 X                    X|             
      Necrosis, Focal                      |                                                                          |             
      Bile Duct, Hyperplasia               | 3  3  3  3  3  3  3  3  3  3  2  3  3  2  2  3  3  2  3  3  3  2  3  3  2|             
      Hepatocyte, Fatty Change             | 1  1     2  2  1     2  1  1  2  2  2  2  1  2  2  1  1  2  1  2     1   |             
      Hepatocyte, Hyperplasia, Regenerative|                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic| 2              2     1     1           2        1     1  2  1           1|             
      Hepatocyte, Centrilobular, Necrosis  |                                                                          |             
      Serosa, Bile Duct, Inflammation,     |                                                                          |             
           Chronic, Focal                  |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  46                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 6| 7| 6| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 0| 3| 2| 2| 4| 0| 3| 3| 3| 0| 3| 3| 4| 9| 1| 3| 8| 2| 9| 2| 3| 3| 7| 3|             
                                           | 6| 9| 7| 9| 9| 2| 9| 1| 1| 1| 9| 1| 1| 8| 5| 9| 1| 6| 9| 3| 9| 1| 1| 2| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    700 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Mesentery                               |       +     +  +                    +        +                           |             
      Hemorrhage, Focal                    |                                                                          |             
      Fat, Necrosis, Focal                 |       3     2                       3                                    |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Histiocytic      |                      1                                                   |             
      Acinus, Atrophy, Focal               | 2  2  1                    1  3     1                 2        1        3|             
      Duct, Cyst, Focal, Multiple          |                                  1  1                       1     1     2|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                        3                                 |             
      Erosion                              |                               1                                          |             
      Inflammation, Focal                  |                               2                                          |             
      Ulcer                                |                                        3                                 |             
      Epithelium, Hyperplasia              | 2                          2                       2                     |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                              2                           |             
      Fibrosis, Focal                      |                            3                                             |             
      Pigmentation, Focal                  |    2                                                                     |             
      Epithelium, Hyperplasia              |                                        3                                 |             
      Glands, Ectasia, Focal               |                            3                                             |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3  1                    2        2              2                 2  2  2|             
      Thrombosis                           |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |    1  1              1                 2                       1  1      |             
      Cytoplasmic Alteration, Focal        |    1                                                                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  47                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 6| 7| 6| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 0| 3| 2| 2| 4| 0| 3| 3| 3| 0| 3| 3| 4| 9| 1| 3| 8| 2| 9| 2| 3| 3| 7| 3|             
                                           | 6| 9| 7| 9| 9| 2| 9| 1| 1| 1| 9| 1| 1| 8| 5| 9| 1| 6| 9| 3| 9| 1| 1| 2| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    700 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |       1     1        1     1     2                 2     1               |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Hyperplasia, Focal                   | 1           2        1  1     2     1                 1  2        2      |             
      Hyperplasia                          |                                                                          |             
      Thrombosis                           |                                           3                              |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                2         |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |                            1           1        1              1         |             
      Pars Distalis, Degeneration, Cystic, |                                                                          |             
           Focal                           |       3  1                                                               |             
      Pars Distalis, Hemorrhage, Focal     |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |       3     2  2                                            2  2         |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  A  +  +  +  +  +  A  +|             
      C-Cell, Hyperplasia                  | 1  2  2  2  2  2  1  2  2  1     1  1  2        2     2  1  2  2  1     2|             
      Follicular Cell, Hyperplasia, Cystic,|                                                                          |             
           Focal                           |                                                                          |             
      Follicular Cell, Hyperplasia         |                                     1                          1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  48                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 6| 7| 6| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 0| 3| 2| 2| 4| 0| 3| 3| 3| 0| 3| 3| 4| 9| 1| 3| 8| 2| 9| 2| 3| 3| 7| 3|             
                                           | 6| 9| 7| 9| 9| 2| 9| 1| 1| 1| 9| 1| 1| 8| 5| 9| 1| 6| 9| 3| 9| 1| 1| 2| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    700 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Cystic                  |                                                                          |             
      Inflammation, Chronic                |    2  2  2  1  1  2  1  2        1     1  1  2     3  1  3  1  2  2     1|             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2  3  3  2  2     3  2  3  1  3  3     2  2  1  1  3  3  3  1     2  2   |             
      Mineralization, Focal                |                            2                                             |             
      Epithelium, Hyperplasia, Focal       | 2     1                 2     1  2        1  2        1        2  1  1  2|             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          3                       3                          3            |             
      Bilateral, Atrophy                   |                                                    4                     |             
      Interstitial Cell, Hyperplasia, Focal|                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
      Hyperplasia                          |                                                                   3      |             
      Myeloid Cell, Hyperplasia            |          3                                                               |             
      Myeloid Cell, Erythroid Cell,        |                                                                          |             
          Hyperplasia                      |       3                                                                  |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +     +        +              +        +  +  +     +  +  +        +      |             
      Deep Cervical, Ectasia               |       3                                                                  |             
      Mediastinal, Angiectasis             |                                        3                                 |             
      Mediastinal, Ectasia                 |       3                                                           3      |             
      Mediastinal, Hemorrhage              |                                        2           3                     |             
      Mediastinal, Hyperplasia, Histiocytic|                                           3                              |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
      Pancreatic, Angiectasis              |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  49                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 6| 7| 6| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 0| 3| 2| 2| 4| 0| 3| 3| 3| 0| 3| 3| 4| 9| 1| 3| 8| 2| 9| 2| 3| 3| 7| 3|             
                                           | 6| 9| 7| 9| 9| 2| 9| 1| 1| 1| 9| 1| 1| 8| 5| 9| 1| 6| 9| 3| 9| 1| 1| 2| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    700 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Pancreatic, Ectasia                  |                                                       3           3      |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Pancreatic, Hyperplasia, Histiocytic |       3                       3                       3                  |             
      Pancreatic, Pigmentation             |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                                                          |             
      Fibrosis, Focal                      |                            2                                             |             
      Hematopoietic Cell Proliferation     |       3  2  2                 2           2                             2|             
      Hemorrhage                           |                                              3                           |             
      Necrosis, Focal                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  M  M  M  +  +  +  I  M  +  +  M  +  +  +  M  +  +  +  M|             
      Dilatation                           |                               2  3                 2     2           2   |             
      Ectasia                              |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                            X           X                                 |             
      Hyperkeratosis, Focal                |          2                                                               |             
      Subcutaneous Tissue, Hemorrhage,     |                                                                          |             
           Focal                           | 3                                                                        |             
      Subcutaneous Tissue, Necrosis, Fatty,|                                                                          |             
           Focal                           |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  50                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 6| 7| 6| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 0| 3| 2| 2| 4| 0| 3| 3| 3| 0| 3| 3| 4| 9| 1| 3| 8| 2| 9| 2| 3| 3| 7| 3|             
                                           | 6| 9| 7| 9| 9| 2| 9| 1| 1| 1| 9| 1| 1| 8| 5| 9| 1| 6| 9| 3| 9| 1| 1| 2| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    700 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                   +                                                      |             
      Hemorrhage, Focal                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |    3              3     3     2  2        3              3           3   |             
      Hemorrhage, Focal                    | 3                                                                        |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        | +              +  +                                                      |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             | +              +  +                                                      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |    3                                                     1           2   |             
      Fibrosis, Focal                      |                                                                          |             
      Hemorrhage, Focal                    | 2                                                                        |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                           2                              |             
      Inflammation, Chronic, Focal         |                         1        1                                       |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                     2              2                     |             
      Mediastinum, Angiectasis, Focal      |                                                                   2      |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                       1           2      |             
      Nasolacrimal Duct, Inflammation      |                                                                          |             
      Olfactory Epithelium, Mineralization,|                                                                          |             
           Focal                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  51                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 6| 7| 6| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 0| 3| 2| 2| 4| 0| 3| 3| 3| 0| 3| 3| 4| 9| 1| 3| 8| 2| 9| 2| 3| 3| 7| 3|             
                                           | 6| 9| 7| 9| 9| 2| 9| 1| 1| 1| 9| 1| 1| 8| 5| 9| 1| 6| 9| 3| 9| 1| 1| 2| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    700 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Retina, Degeneration                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |       +                          +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy                          | 1  1  3  2  2  1  1  2  2  2  3  2  2  1  2     2     2  2  3  2  2  1  1|             
      Cortex, Necrosis, Focal              |                                                                          |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                          |             
      Renal Tubule, Hyperplasia, Atypical, |                                                                          |             
           Focal                           |                                                                          |             
      Renal Tubule, Pigmentation           |                                                          2               |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  52                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 6| 6| 6| 7| 4| 7| 6| 6| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 2| 5| 3| 5| 3| 1| 0| 3| 4| 3| 8| 3| 3| 4| 3| 8| 3| 3| 3| 3| 0|            |
                                           | 0| 0| 9| 2| 9| 4| 5| 4| 5| 6| 5| 3| 2| 5| 5| 2| 3| 4| 2| 6| 2| 2| 2| 1| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    700 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  A  +  +  A  +  +  +  +  +|  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  A  +  +  A  +  +  +  +  +|  43        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  A  +  +  A  +  +  +  +  +|  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  A  +  +  A  +  +  +  +  +|  42        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                                                          |      2  1.5|
      Basophilic Focus                     |    X  X           X                    X                 X  X  X     X   |     17     |
      Cholangiofibrosis                    |                                                                          |      1  2.0|
      Clear Cell Focus                     |       X     X     X                                            X  X  X   |     17     |
      Congestion                           |                                        2                                 |      4  2.8|
      Degeneration, Cystic, Focal          |    2  2  1  2  2  1  2        2     2  2     2                 2  2  2   |     29  1.8|
      Fibrosis, Focal                      |                                           2                              |      3  2.7|
      Hemorrhage, Focal                    |       3                                                                  |      1  3.0|
      Hepatodiaphragmatic Nodule           |          2                                   X           2               |      4  2.3|
      Hyperplasia, Focal, Regenerative     |                                                                          |      1  4.0|
      Infiltration Cellular, Mixed Cell    | 2  2  2  2     2  2  1        2  1     2  2              1  2     2  2  2|     34  1.9|
      Inflammation, Chronic                | 2  1  1  2  2  1  2  2        2        1  2           1  1  2  1  2  2  1|     34  1.5|
      Mixed Cell Focus                     |                   X                                                      |      4     |
      Necrosis, Focal                      |       2                                                                  |      1  2.0|
      Bile Duct, Hyperplasia               | 3  3  3  3  2  3  3  3  4  3  2  2  3  3  2  3  3  3  3  3  3  3  3  3  3|     50  2.8|
      Hepatocyte, Fatty Change             | 1  2  1     2        2     1     2  2  2  2     4  2  2  2  1  1  1  1  2|     40  1.6|
      Hepatocyte, Hyperplasia, Regenerative|                                              1                           |      1  1.0|
      Hepatocyte, Vacuolization Cytoplasmic|                                  1     1           2     1     2  2  1  1|     18  1.4|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  53                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 6| 6| 6| 7| 4| 7| 6| 6| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 2| 5| 3| 5| 3| 1| 0| 3| 4| 3| 8| 3| 3| 4| 3| 8| 3| 3| 3| 3| 0|            |
                                           | 0| 0| 9| 2| 9| 4| 5| 4| 5| 6| 5| 3| 2| 5| 5| 2| 3| 4| 2| 6| 2| 2| 2| 1| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    700 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Hepatocyte, Centrilobular, Necrosis  |                                  3        2  3                          2|      4  2.5|
      Serosa, Bile Duct, Inflammation,     |                                                                          |            |
           Chronic, Focal                  |                                        2                                 |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +     +           +        +  +     +        +  +  +        +            |  15        |
      Hemorrhage, Focal                    |                                              3                           |      1  3.0|
      Fat, Necrosis, Focal                 | 3                 3           3              3                           |      7  2.9|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal, Histiocytic      |                                                                          |      1  1.0|
      Acinus, Atrophy, Focal               | 2        3  3     1           2        2  3  3              2  2  2     1|     21  2.0|
      Duct, Cyst, Focal, Multiple          |             2     2                                            2  1  2  2|     11  1.5|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                      3        3     2                                    |      4  2.8|
      Erosion                              |                                                                          |      1  1.0|
      Inflammation, Focal                  |                                                                          |      1  2.0|
      Ulcer                                |                      2        2                 2                        |      4  2.3|
      Epithelium, Hyperplasia              |                      1              2           2                        |      6  1.8|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                            2     2           2                           |      4  2.0|
      Fibrosis, Focal                      |                                                                          |      1  3.0|
      Pigmentation, Focal                  |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                           1                              |      2  2.0|
      Glands, Ectasia, Focal               |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                     +                                    |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  54                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 6| 6| 6| 7| 4| 7| 6| 6| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 2| 5| 3| 5| 3| 1| 0| 3| 4| 3| 8| 3| 3| 4| 3| 8| 3| 3| 3| 3| 0|            |
                                           | 0| 0| 9| 2| 9| 4| 5| 4| 5| 6| 5| 3| 2| 5| 5| 2| 3| 4| 2| 6| 2| 2| 2| 1| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    700 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
      Cardiomyopathy                       |                      2        1        2        1              2     2   |     14  1.9|
      Thrombosis                           |                                                    3                     |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Accessory Adrenal Cortical Nodule    | 1     1                       1     1     1              1           1  1|     14  1.1|
      Cytoplasmic Alteration, Focal        |                1                                                         |      2  1.0|
      Necrosis, Focal                      |                                                                         2|      1  2.0|
      Vacuolization Cytoplasmic, Focal     |                1     1        1                    1           1         |     12  1.2|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cytoplasmic Alteration, Focal        |    1                                                                     |      1  1.0|
      Hyperplasia, Focal                   |       2                                2           1                    1|     13  1.5|
      Hyperplasia                          |                                              1                           |      1  1.0|
      Thrombosis                           |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                              2                           |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                 3                        |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                                        1                                2|      2  1.5|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |       1                                                           1      |      6  1.0|
      Pars Distalis, Degeneration, Cystic, |                                                                          |            |
           Focal                           |                                              2                           |      3  2.0|
      Pars Distalis, Hemorrhage, Focal     |                                  3           3     2                     |      3  2.7|
      Pars Distalis, Hyperplasia, Focal    |                                           2                          2   |      7  2.1|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  A  +  +  A  +  +  +  +  +|  42        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  55                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 6| 6| 6| 7| 4| 7| 6| 6| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 2| 5| 3| 5| 3| 1| 0| 3| 4| 3| 8| 3| 3| 4| 3| 8| 3| 3| 3| 3| 0|            |
                                           | 0| 0| 9| 2| 9| 4| 5| 4| 5| 6| 5| 3| 2| 5| 5| 2| 3| 4| 2| 6| 2| 2| 2| 1| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    700 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      C-Cell, Hyperplasia                  | 2  1  1  1  2  2  1  1  2     2     1  2  1  3     1  3     1  2  2  2  2|     41  1.7|
      Follicular Cell, Hyperplasia, Cystic,|                                                                          |            |
           Focal                           |                3                    2                       2            |      3  2.3|
      Follicular Cell, Hyperplasia         |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |       +                                                                  |   1        |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                +                    +           +                        |   4        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Cystic                 |                      3           2                                       |      2  2.5|
      Fibrosis                             |                      3                                                   |      1  3.0|
      Hyperplasia, Cystic                  |                2                                2                        |      2  2.0|
      Inflammation, Chronic                | 2  2  2  2        1  1  1  2  1  2  1  2     2     2        2  2  2     2|     37  1.7|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |          2     2  2  3  3     3  2  3  3  1  3     2  2  1  1        3  2|     38  2.2|
      Mineralization, Focal                |    2                                                                     |      2  2.0|
      Epithelium, Hyperplasia, Focal       |       2     2  2  1  2           1     2     1     2           2  2      |     23  1.6|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 3                       3        3     3           3                     |      8  3.0|
      Bilateral, Atrophy                   |                                                                          |      1  4.0|
      Interstitial Cell, Hyperplasia, Focal| 2                             2                                          |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  56                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 6| 6| 6| 7| 4| 7| 6| 6| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 2| 5| 3| 5| 3| 1| 0| 3| 4| 3| 8| 3| 3| 4| 3| 8| 3| 3| 3| 3| 0|            |
                                           | 0| 0| 9| 2| 9| 4| 5| 4| 5| 6| 5| 3| 2| 5| 5| 2| 3| 4| 2| 6| 2| 2| 2| 1| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    700 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal, Histiocytic      |             1                                                            |      1  1.0|
      Hyperplasia                          |                         4                                                |      2  3.5|
      Myeloid Cell, Hyperplasia            |                                                                          |      1  3.0|
      Myeloid Cell, Erythroid Cell,        |                                                                          |            |
          Hyperplasia                      |                3                 3                          3        2   |      5  2.8|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +     +     +           +  +     +  +  +  +  +  +  +  +     +  +         |  26        |
      Deep Cervical, Ectasia               |                                                                          |      1  3.0|
      Mediastinal, Angiectasis             |                                                                          |      1  3.0|
      Mediastinal, Ectasia                 | 3           3                                                            |      4  3.0|
      Mediastinal, Hemorrhage              |                                                                          |      2  2.5|
      Mediastinal, Hyperplasia, Histiocytic|                                                             3            |      2  3.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                  3                                       |      1  3.0|
      Pancreatic, Angiectasis              |                                           3                              |      1  3.0|
      Pancreatic, Ectasia                  |             3                                               3  3         |      5  3.0|
      Pancreatic, Hemorrhage               |       3                                                                  |      1  3.0|
      Pancreatic, Hyperplasia, Histiocytic | 3     3                                                                  |      5  3.0|
      Pancreatic, Pigmentation             |                                           2                              |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                   3                                                      |      1  3.0|
      Hyperplasia, Histiocytic             |                                                                      3   |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Spleen                     |                                              X                           |      1     |
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |             2  3                 3        2                 2            |     11  2.3|
      Hemorrhage                           |                                              3                           |      2  3.0|
      Necrosis, Focal                      |                                              3                           |      1  3.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  57                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 6| 6| 6| 7| 4| 7| 6| 6| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 2| 5| 3| 5| 3| 1| 0| 3| 4| 3| 8| 3| 3| 4| 3| 8| 3| 3| 3| 3| 0|            |
                                           | 0| 0| 9| 2| 9| 4| 5| 4| 5| 6| 5| 3| 2| 5| 5| 2| 3| 4| 2| 6| 2| 2| 2| 1| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    700 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  I  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  42        |
      Dilatation                           |                   3  2  3     2     2              2  3                  |     12  2.3|
      Ectasia                              |                                                          2               |      1  2.0|
      Fibrosis, Focal                      |    3                                                                     |      1  3.0|
      Hyperplasia                          |                                              3                           |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                                          |      2     |
      Hyperkeratosis, Focal                |                                                                          |      1  2.0|
      Subcutaneous Tissue, Hemorrhage,     |                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
      Subcutaneous Tissue, Necrosis, Fatty,|                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |          +                                                               |   2        |
      Hemorrhage, Focal                    |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression, Focal                   |          3        2  3  3     3              3                           |     14  2.8|
      Hemorrhage, Focal                    |                            3                    2                        |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                      +                             +                     |   5        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                      +                             +                     |   5        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  58                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 6| 6| 6| 7| 4| 7| 6| 6| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 2| 5| 3| 5| 3| 1| 0| 3| 4| 3| 8| 3| 3| 4| 3| 8| 3| 3| 3| 3| 0|            |
                                           | 0| 0| 9| 2| 9| 4| 5| 4| 5| 6| 5| 3| 2| 5| 5| 2| 3| 4| 2| 6| 2| 2| 2| 1| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    700 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                  3                       3               |      5  2.4|
      Fibrosis, Focal                      |                                              2                           |      1  2.0|
      Hemorrhage, Focal                    |                                              2                           |      2  2.0|
      Hemorrhage                           |                                                          3               |      1  3.0|
      Hyperplasia, Histiocytic             |                                           1              1               |      2  1.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                                                                          |      2  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |    2                    2                    3                           |      5  2.2|
      Mediastinum, Angiectasis, Focal      |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                   1                                                      |      3  1.3|
      Nasolacrimal Duct, Inflammation      | 1                                                                        |      1  1.0|
      Olfactory Epithelium, Mineralization,|                                                                          |            |
           Focal                           |                                                          2               |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  47        |
      Retina, Degeneration                 |                                                    3                     |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |          2                                                               |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  59                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 05/24/04    
Route: DOSED WATER                                                                                                Time: 09:32:41    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 6| 6| 6| 7| 4| 7| 6| 6| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 2| 5| 3| 5| 3| 1| 0| 3| 4| 3| 8| 3| 3| 4| 3| 8| 3| 3| 3| 3| 0|            |
                                           | 0| 0| 9| 2| 9| 4| 5| 4| 5| 6| 5| 3| 2| 5| 5| 2| 3| 4| 2| 6| 2| 2| 2| 1| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    700 MG/L                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Nephropathy                          |    1  2  2  1  2  2  3  1     1  2  2  2  2  1  1  1  2  2  2  2  2  2  2|     46  1.8|
      Cortex, Necrosis, Focal              |                                                    2                     |      1  2.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                         2|      1  2.0|
      Renal Tubule, Hyperplasia, Atypical, |                                                                          |            |
           Focal                           |                                              1                           |      1  1.0|
      Renal Tubule, Pigmentation           |                2                                            3            |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  60                                                               
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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