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TDMS Study 96018-03 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst               WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                 DATE: 05/24/04       
EXPERIMENT: 96018 TEST: 03                                                                                     TIME: 09:34:02       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: C96018       
PATHOLOGIST: FARNELL, DANIEL R.                                                                                CAS: 75-27-4         
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                                                           FINAL #2/RATS                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst               WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                 DATE: 05/24/04       
EXPERIMENT: 96018 TEST: 03                                                                                     TIME: 09:34:02       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: C96018       
PATHOLOGIST: FARNELL, DANIEL R.                                                                                CAS: 75-27-4         
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF  WATER DISINFECTION BYPRODUCTS (BROMODICHL                                                                       
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Bone Marrow: Myeloid Cell, Erythroid Cell                                                                                           
                                       Hyperplasia                                                                                  
Brain                                  Compression Focal                                                                            
Islets, Pancreatic                     Hyperplasia Focal                                                                            
Kidney                                 Nephropathy                                                                                  
Kidney: Renal Tubule                   Pigmentation                                                                                 
Liver                                  Basophilic Focus                                                                             
                                       Clear Cell Focus                                                                             
                                       Degeneration Cystic Focal                                                                    
                                       Inflammation Chronic                                                                         
                                       Mixed Cell Focus                                                                             
Liver: Bile Duct                       Hyperplasia                                                                                  
Liver: Hepatocyte                      Vacuolization Cytoplasmic                                                                    
Mammary Gland                          Dilatation                                                                                   
Pancreas: Acinus                       Atrophy Focal                                                                                
Pituitary Gland: Pars Distalis         Cytoplasmic Alteration Focal                                                                 
                                       Degeneration Cystic Focal                                                                    
                                       Hyperplasia Focal                                                                            
Prostate                               Inflammation Chronic                                                                         
                                       Mineralization Focal                                                                         
Skin                                   Cyst Epithelial Inclusion                                                                    
Spleen                                 Hemorrhage                                                                                   
Stomach, Glandular: Epithelium         Hyperplasia                                                                                  
Thyroid Gland: Follicular Cell         Hyperplasia                                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Accessory Adrenal Cortical Nodule                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  14/50 (28%)              8/50 (16%)               8/50 (16%)               14/49 (29%)     | 
|POLY-3 RATE (b)    |                  14/43.85                 8/43.48                  8/45.09                  14/45.27        | 
|POLY-3 PERCENT (g) |                  31.9%                    18.4%                    17.7%                    30.9%           | 
|TERMINAL (d)       |                  10/29 (35%)              5/28 (18%)               4/29 (14%)               6/26 (23%)      | 
|FIRST INCIDENCE    |                  479                      660                      628                      448             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.336                  P=0.141N                 P=0.122N                 P=0.489         | 
|POLY 3             |                  P=0.440                  P=0.110N                 P=0.093N                 P=0.550N        | 
|POLY 1.5           |                  P=0.422                  P=0.109N                 P=0.099N                 P=0.568N        | 
|POLY 6             |                  P=0.453                  P=0.116N                 P=0.089N                 P=0.544N        | 
|LOGISTIC REGRESSION|                  P=0.386                  P=0.111N                 P=0.100N                 P=0.559         | 
|COCH-ARM / FISHERS |                  P=0.386                  P=0.114N                 P=0.114N                 P=0.563         | 
|ORDER RESTRICTED   |                  P=0.231N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Cytoplasmic Alteration Focal                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                3/50 (6%)                3/50 (6%)                2/49 (4%)       | 
|POLY-3 RATE (b)    |                  1/42.98                  3/43.88                  3/44.50                  2/42.48         | 
|POLY-3 PERCENT (g) |                  2.3%                     6.8%                     6.7%                     4.7%            | 
|TERMINAL (d)       |                  0/29 (0%)                1/28 (4%)                2/29 (7%)                0/26 (0%)       | 
|FIRST INCIDENCE    |                  680                      498                      633                      554             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.453                  P=0.311                  P=0.312                  P=0.477         | 
|POLY 3             |                  P=0.472                  P=0.312                  P=0.318                  P=0.496         | 
|POLY 1.5           |                  P=0.473                  P=0.311                  P=0.314                  P=0.497         | 
|POLY 6             |                  P=0.462                  P=0.310                  P=0.317                  P=0.490         | 
|LOGISTIC REGRESSION|                  P=0.450                  P=0.285                  P=0.308                  P=0.476         | 
|COCH-ARM / FISHERS |                  P=0.468                  P=0.309                  P=0.309                  P=0.492         | 
|ORDER RESTRICTED   |                  P=0.346                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                0/50 (0%)                1/50 (2%)                1/49 (2%)       | 
|POLY-3 RATE (b)    |                  2/42.93                  0/42.97                  1/44.15                  1/41.94         | 
|POLY-3 PERCENT (g) |                  4.7%                     0.0%                     2.3%                     2.4%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/28 (0%)                1/29 (3%)                0/26 (0%)       | 
|FIRST INCIDENCE    |                  702                      ---                      729 (T)                  705             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.530N                 P=0.268N                 P=0.503N                 P=0.547N        | 
|POLY 3             |                  P=0.505N                 P=0.237N                 P=0.490N                 P=0.508N        | 
|POLY 1.5           |                  P=0.505N                 P=0.236N                 P=0.492N                 P=0.506N        | 
|POLY 6             |                  P=0.505N                 P=0.240N                 P=0.492N                 P=0.516N        | 
|LOGISTIC REGRESSION|                  P=0.514N                 P=0.239N                 P=0.491N                 P=0.513N        | 
|COCH-ARM / FISHERS |                  P=0.506N                 P=0.247N                 P=0.500N                 P=0.508N        | 
|ORDER RESTRICTED   |                  P=0.275N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Vacuolization Cytoplasmic Focal                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  9/50 (18%)               5/50 (10%)               8/50 (16%)               12/49 (24%)     | 
|POLY-3 RATE (b)    |                  9/44.03                  5/43.14                  8/45.05                  12/44.06        | 
|POLY-3 PERCENT (g) |                  20.4%                    11.6%                    17.8%                    27.2%           | 
|TERMINAL (d)       |                  6/29 (21%)               4/28 (14%)               2/29 (7%)                5/26 (19%)      | 
|FIRST INCIDENCE    |                  553                      683                      642                      554             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.112                  P=0.209N                 P=0.492N                 P=0.262         | 
|POLY 3             |                  P=0.139                  P=0.202N                 P=0.479N                 P=0.309         | 
|POLY 1.5           |                  P=0.136                  P=0.195N                 P=0.483N                 P=0.307         | 
|POLY 6             |                  P=0.143                  P=0.217N                 P=0.481N                 P=0.305         | 
|LOGISTIC REGRESSION|                  P=0.129                  P=0.191N                 P=0.490N                 P=0.292         | 
|COCH-ARM / FISHERS |                  P=0.128                  P=0.194N                 P=0.500N                 P=0.294         | 
|ORDER RESTRICTED   |                  P=0.140                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  11/50 (22%)              18/50 (36%)              15/50 (30%)              13/49 (27%)     | 
|POLY-3 RATE (b)    |                  11/43.29                 18/44.89                 15/44.95                 13/42.80        | 
|POLY-3 PERCENT (g) |                  25.4%                    40.1%                    33.4%                    30.4%           | 
|TERMINAL (d)       |                  8/29 (28%)               10/28 (36%)              12/29 (41%)              8/26 (31%)      | 
|FIRST INCIDENCE    |                  620                      526                      605                      636             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.414                  P=0.087                  P=0.251                  P=0.305         | 
|POLY 3             |                  P=0.511                  P=0.104                  P=0.278                  P=0.392         | 
|POLY 1.5           |                  P=0.516                  P=0.100                  P=0.270                  P=0.395         | 
|POLY 6             |                  P=0.491                  P=0.105                  P=0.278                  P=0.377         | 
|LOGISTIC REGRESSION|                  P=0.496                  P=0.091                  P=0.271                  P=0.358         | 
|COCH-ARM / FISHERS |                  P=0.504                  P=0.093                  P=0.247                  P=0.385         | 
|ORDER RESTRICTED   |                  P=0.284                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                3/45 (7%)                5/49 (10%)               2/49 (4%)       | 
|POLY-3 RATE (b)    |                  2/43.06                  3/39.89                  5/43.55                  2/41.76         | 
|POLY-3 PERCENT (g) |                  4.6%                     7.5%                     11.5%                    4.8%            | 
|TERMINAL (d)       |                  0/29 (0%)                2/27 (7%)                4/29 (14%)               2/26 (8%)       | 
|FIRST INCIDENCE    |                  680                      709                      721                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.530                  P=0.463                  P=0.218                  P=0.649         | 
|POLY 3             |                  P=0.573                  P=0.465                  P=0.220                  P=0.683         | 
|POLY 1.5           |                  P=0.575N                 P=0.463                  P=0.217                  P=0.687         | 
|POLY 6             |                  P=0.552                  P=0.462                  P=0.218                  P=0.673         | 
|LOGISTIC REGRESSION|                  P=0.552                  P=0.466                  P=0.222                  P=0.679         | 
|COCH-ARM / FISHERS |                  P=0.573N                 P=0.450                  P=0.210                  P=0.684         | 
|ORDER RESTRICTED   |                  P=0.414                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow: Myeloid Cell                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                0/45 (0%)                3/49 (6%)                1/49 (2%)       | 
|POLY-3 RATE (b)    |                  2/42.82                  0/39.81                  3/44.14                  1/41.76         | 
|POLY-3 PERCENT (g) |                  4.7%                     0.0%                     6.8%                     2.4%            | 
|TERMINAL (d)       |                  1/29 (3%)                0/27 (0%)                2/29 (7%)                1/26 (4%)       | 
|FIRST INCIDENCE    |                  722                      ---                      526                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.582N                 P=0.259N                 P=0.506                  P=0.541N        | 
|POLY 3             |                  P=0.560N                 P=0.253N                 P=0.514                  P=0.509N        | 
|POLY 1.5           |                  P=0.555N                 P=0.255N                 P=0.507                  P=0.506N        | 
|POLY 6             |                  P=0.568N                 P=0.254N                 P=0.518                  P=0.517N        | 
|LOGISTIC REGRESSION|                  P=0.551N                 P=0.261N                 P=0.489                  P=0.544N        | 
|COCH-ARM / FISHERS |                  P=0.551N                 P=0.274N                 P=0.490                  P=0.508N        | 
|ORDER RESTRICTED   |                  P=0.452N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow: Myeloid Cell, Erythroid Cell                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                5/45 (11%)               0/49 (0%)                5/49 (10%)      | 
|POLY-3 RATE (b)    |                  1/43.18                  5/41.48                  0/43.51                  5/43.00         | 
|POLY-3 PERCENT (g) |                  2.3%                     12.1%                    0.0%                     11.6%           | 
|TERMINAL (d)       |                  0/29 (0%)                1/27 (4%)                0/29 (0%)                2/26 (8%)       | 
|FIRST INCIDENCE    |                  620                      556                      ---                      554             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.159                  P=0.111                  P=0.491N                 P=0.105         | 
|POLY 3             |                  P=0.167                  P=0.091                  P=0.498N                 P=0.100         | 
|POLY 1.5           |                  P=0.167                  P=0.087                  P=0.500N                 P=0.100         | 
|POLY 6             |                  P=0.164                  P=0.094                  P=0.499N                 P=0.097         | 
|LOGISTIC REGRESSION|                  P=0.147                  P=0.040 *                P=0.548N                 P=0.088         | 
|COCH-ARM / FISHERS |                  P=0.165                  P=0.080                  P=0.505N                 P=0.098         | 
|ORDER RESTRICTED   |                  P=0.052                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Compression Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  6/50 (12%)               8/50 (16%)               14/50 (28%)              14/50 (28%)     | 
|POLY-3 RATE (b)    |                  6/44.19                  8/44.04                  14/46.55                 14/43.91        | 
|POLY-3 PERCENT (g) |                  13.6%                    18.2%                    30.1%                    31.9%           | 
|TERMINAL (d)       |                  3/29 (10%)               2/28 (7%)                6/29 (21%)               5/26 (19%)      | 
|FIRST INCIDENCE    |                  526                      624                      430                      605             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.018 *                P=0.376                  P=0.058                  P=0.034 *       | 
|POLY 3             |                  P=0.017 *                P=0.383                  P=0.048 *                P=0.033 *       | 
|POLY 1.5           |                  P=0.018 *                P=0.388                  P=0.045 *                P=0.036 *       | 
|POLY 6             |                  P=0.014 *                P=0.374                  P=0.049 *                P=0.029 *       | 
|LOGISTIC REGRESSION|                  P=0.020 *                P=0.383                  P=0.030 *                P=0.040 *       | 
|COCH-ARM / FISHERS |                  P=0.020 *                P=0.387                  P=0.039 *                P=0.039 *       | 
|ORDER RESTRICTED   |                  P=0.028 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hemorrhage Focal                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                4/50 (8%)                1/50 (2%)                3/50 (6%)       | 
|POLY-3 RATE (b)    |                  2/43.54                  4/45.24                  1/44.39                  3/43.52         | 
|POLY-3 PERCENT (g) |                  4.6%                     8.8%                     2.3%                     6.9%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/28 (0%)                0/29 (0%)                0/26 (0%)       | 
|FIRST INCIDENCE    |                  479                      405                      665                      616             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.536                  P=0.342                  P=0.486N                 P=0.500         | 
|POLY 3             |                  P=0.542                  P=0.355                  P=0.493N                 P=0.500         | 
|POLY 1.5           |                  P=0.545                  P=0.350                  P=0.494N                 P=0.502         | 
|POLY 6             |                  P=0.536                  P=0.355                  P=0.494N                 P=0.493         | 
|LOGISTIC REGRESSION|                  P=0.436                  P=0.214                  P=0.571N                 P=0.450         | 
|COCH-ARM / FISHERS |                  P=0.544                  P=0.339                  P=0.500N                 P=0.500         | 
|ORDER RESTRICTED   |                  P=0.507                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hydrocephalus                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                0/50 (0%)                2/50 (4%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  0/42.79                  0/42.97                  2/44.82                  0/42.45         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     4.5%                     0.0%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/28 (0%)                0/29 (0%)                0/26 (0%)       | 
|FIRST INCIDENCE    |                  ---                      ---                      633                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.595                  (e)                      P=0.253                  (e)             | 
|POLY 3             |                  P=0.587                  (e)                      P=0.247                  (e)             | 
|POLY 1.5           |                  P=0.593                  (e)                      P=0.244                  (e)             | 
|POLY 6             |                  P=0.572                  (e)                      P=0.250                  (e)             | 
|LOGISTIC REGRESSION|                  P=0.577                  (e)                      P=0.201                  (e)             | 
|COCH-ARM / FISHERS |                  P=0.595                  (e)                      P=0.247                  (e)             | 
|ORDER RESTRICTED   |                  P=0.256                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                2/50 (4%)                0/50 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  1/43.51                  2/44.43                  0/44.15                  0/42.45         | 
|POLY-3 PERCENT (g) |                  2.3%                     4.5%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/28 (0%)                0/29 (0%)                0/26 (0%)       | 
|FIRST INCIDENCE    |                  479                      405                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.185N                 P=0.512                  P=0.492N                 P=0.492N        | 
|POLY 3             |                  P=0.189N                 P=0.507                  P=0.497N                 P=0.505N        | 
|POLY 1.5           |                  P=0.188N                 P=0.506                  P=0.497N                 P=0.502N        | 
|POLY 6             |                  P=0.192N                 P=0.505                  P=0.499N                 P=0.512N        | 
|LOGISTIC REGRESSION|                  P=0.368N                 P=0.281                  P=0.698N                 P=0.665N        | 
|COCH-ARM / FISHERS |                  P=0.188N                 P=0.500                  P=0.500N                 P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.176N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Cataract                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/49 (4%)                1/49 (2%)                7/48 (15%)               0/47 (0%)       | 
|POLY-3 RATE (b)    |                  2/42.07                  1/42.65                  7/43.43                  0/40.57         | 
|POLY-3 PERCENT (g) |                  4.8%                     2.3%                     16.1%                    0.0%            | 
|TERMINAL (d)       |                  2/29 (7%)                1/28 (4%)                3/29 (10%)               0/26 (0%)       | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  605                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.411N                 P=0.512N                 P=0.087                  P=0.262N        | 
|POLY 3             |                  P=0.389N                 P=0.495N                 P=0.085                  P=0.245N        | 
|POLY 1.5           |                  P=0.386N                 P=0.495N                 P=0.082                  P=0.244N        | 
|POLY 6             |                  P=0.400N                 P=0.500N                 P=0.088                  P=0.249N        | 
|LOGISTIC REGRESSION|                  P=0.391N                 P=0.512N                 P=0.084                  (e)             | 
|COCH-ARM / FISHERS |                  P=0.391N                 P=0.500N                 P=0.075                  P=0.258N        | 
|ORDER RESTRICTED   |                  P=0.097N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Retina                                                                                                                      | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/49 (6%)                1/49 (2%)                8/48 (17%)               1/47 (2%)       | 
|POLY-3 RATE (b)    |                  3/42.07                  1/42.65                  8/43.66                  1/40.89         | 
|POLY-3 PERCENT (g) |                  7.1%                     2.3%                     18.3%                    2.5%            | 
|TERMINAL (d)       |                  3/29 (10%)               1/28 (4%)                3/29 (10%)               0/26 (0%)       | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  605                      644             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.490N                 P=0.316N                 P=0.109                  P=0.345N        | 
|POLY 3             |                  P=0.460N                 P=0.300N                 P=0.109                  P=0.315N        | 
|POLY 1.5           |                  P=0.460N                 P=0.300N                 P=0.103                  P=0.315N        | 
|POLY 6             |                  P=0.465N                 P=0.304N                 P=0.114                  P=0.318N        | 
|LOGISTIC REGRESSION|                  P=0.464N                 P=0.316N                 P=0.104                  P=0.320N        | 
|COCH-ARM / FISHERS |                  P=0.467N                 P=0.309N                 P=0.093                  P=0.324N        | 
|ORDER RESTRICTED   |                  P=0.181N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  16/50 (32%)              18/50 (36%)              21/50 (42%)              14/50 (28%)     | 
|POLY-3 RATE (b)    |                  16/46.51                 18/45.23                 21/46.21                 14/44.13        | 
|POLY-3 PERCENT (g) |                  34.4%                    39.8%                    45.5%                    31.7%           | 
|TERMINAL (d)       |                  9/29 (31%)               11/28 (39%)              13/29 (45%)              8/26 (31%)      | 
|FIRST INCIDENCE    |                  354                      405                      548                      605             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.470N                 P=0.390                  P=0.241                  P=0.515N        | 
|POLY 3             |                  P=0.424N                 P=0.374                  P=0.189                  P=0.481N        | 
|POLY 1.5           |                  P=0.394N                 P=0.394                  P=0.194                  P=0.452N        | 
|POLY 6             |                  P=0.463N                 P=0.347                  P=0.184                  P=0.519N        | 
|LOGISTIC REGRESSION|                  P=0.355N                 P=0.400                  P=0.179                  P=0.422N        | 
|COCH-ARM / FISHERS |                  P=0.353N                 P=0.417                  P=0.204                  P=0.414N        | 
|ORDER RESTRICTED   |                  P=0.332N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                2/50 (4%)                0/50 (0%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  0/42.79                  2/43.23                  0/44.15                  2/42.90         | 
|POLY-3 PERCENT (g) |                  0.0%                     4.6%                     0.0%                     4.7%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/28 (0%)                0/29 (0%)                0/26 (0%)       | 
|FIRST INCIDENCE    |                  ---                      681                      ---                      644             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.224                  P=0.226                  (e)                      P=0.219         | 
|POLY 3             |                  P=0.249                  P=0.239                  (e)                      P=0.237         | 
|POLY 1.5           |                  P=0.250                  P=0.239                  (e)                      P=0.239         | 
|POLY 6             |                  P=0.244                  P=0.237                  (e)                      P=0.233         | 
|LOGISTIC REGRESSION|                  P=0.247                  P=0.238                  (e)                      P=0.235         | 
|COCH-ARM / FISHERS |                  P=0.247                  P=0.247                  (e)                      P=0.247         | 
|ORDER RESTRICTED   |                  P=0.116                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/49 (4%)                0/50 (0%)                0/50 (0%)                0/49 (0%)       | 
|POLY-3 RATE (b)    |                  2/43.01                  0/42.97                  0/44.15                  0/41.84         | 
|POLY-3 PERCENT (g) |                  4.7%                     0.0%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  1/29 (3%)                0/28 (0%)                0/29 (0%)                0/26 (0%)       | 
|FIRST INCIDENCE    |                  620                      ---                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.119N                 P=0.241N                 P=0.235N                 P=0.252N        | 
|POLY 3             |                  P=0.110N                 P=0.237N                 P=0.231N                 P=0.243N        | 
|POLY 1.5           |                  P=0.111N                 P=0.235N                 P=0.231N                 P=0.240N        | 
|POLY 6             |                  P=0.107N                 P=0.242N                 P=0.233N                 P=0.250N        | 
|LOGISTIC REGRESSION|                  P=0.115N                 P=0.233N                 P=0.238N                 P=0.237N        | 
|COCH-ARM / FISHERS |                  P=0.114N                 P=0.242N                 P=0.242N                 P=0.247N        | 
|ORDER RESTRICTED   |                  P=0.031N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/49 (0%)                3/50 (6%)                1/50 (2%)                0/49 (0%)       | 
|POLY-3 RATE (b)    |                  0/42.62                  3/43.54                  1/44.39                  0/41.61         | 
|POLY-3 PERCENT (g) |                  0.0%                     6.9%                     2.3%                     0.0%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/28 (0%)                0/29 (0%)                0/26 (0%)       | 
|FIRST INCIDENCE    |                  ---                      660                      665                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.392N                 P=0.121                  P=0.515                  (e)             | 
|POLY 3             |                  P=0.373N                 P=0.122                  P=0.508                  (e)             | 
|POLY 1.5           |                  P=0.369N                 P=0.123                  P=0.507                  (e)             | 
|POLY 6             |                  P=0.384N                 P=0.121                  P=0.508                  (e)             | 
|LOGISTIC REGRESSION|                  P=0.367N                 P=0.124                  P=0.495                  (e)             | 
|COCH-ARM / FISHERS |                  P=0.367N                 P=0.125                  P=0.505                  (e)             | 
|ORDER RESTRICTED   |                  P=0.230N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  49/49 (100%)             50/50 (100%)             49/50 (98%)              46/49 (94%)     | 
|POLY-3 RATE (b)    |                  49/49.00                 50/50.00                 49/49.85                 46/48.22        | 
|POLY-3 PERCENT (g) |                  100.0%                   100.0%                   98.3%                    95.4%           | 
|TERMINAL (d)       |                  29/29 (100%)             28/28 (100%)             29/29 (100%)             25/26 (96%)     | 
|FIRST INCIDENCE    |                  354                      405                      430                      448             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.504                  (e)                      P=0.539N                 P=0.489         | 
|POLY 3             |                  P=0.032N*                (e)                      P=0.572N                 P=0.172N        | 
|POLY 1.5           |                  P=0.024N*                (e)                      P=0.537N                 P=0.142N        | 
|POLY 6             |                  P=0.055N                 (e)                      P=0.650N                 P=0.248N        | 
|LOGISTIC REGRESSION|                  P=0.020N*                (e)                      P=0.504N                 P=0.119N        | 
|COCH-ARM / FISHERS |                  P=0.020N*                (e)                      P=0.505N                 P=0.121N        | 
|ORDER RESTRICTED   |                  P=0.029N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  10/49 (20%)              13/50 (26%)              7/50 (14%)               3/49 (6%)       | 
|POLY-3 RATE (b)    |                  10/45.95                 13/44.78                 7/45.64                  3/42.31         | 
|POLY-3 PERCENT (g) |                  21.8%                    29.0%                    15.3%                    7.1%            | 
|TERMINAL (d)       |                  1/29 (3%)                8/28 (29%)               4/29 (14%)               1/26 (4%)       | 
|FIRST INCIDENCE    |                  354                      498                      526                      554             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.021N*                P=0.312                  P=0.301N                 P=0.060N        | 
|POLY 3             |                  P=0.015N*                P=0.289                  P=0.301N                 P=0.048N*       | 
|POLY 1.5           |                  P=0.013N*                P=0.309                  P=0.293N                 P=0.042N*       | 
|POLY 6             |                  P=0.020N*                P=0.263                  P=0.315N                 P=0.058N        | 
|LOGISTIC REGRESSION|                  P=0.010N*                P=0.334                  P=0.344N                 P=0.031N*       | 
|COCH-ARM / FISHERS |                  P=0.011N*                P=0.337                  P=0.282N                 P=0.035N*       | 
|ORDER RESTRICTED   |                  P=0.017N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  4/50 (8%)                4/50 (8%)                5/50 (10%)               2/50 (4%)       | 
|POLY-3 RATE (b)    |                  4/42.79                  4/43.05                  5/44.26                  2/42.66         | 
|POLY-3 PERCENT (g) |                  9.4%                     9.3%                     11.3%                    4.7%            | 
|TERMINAL (d)       |                  4/29 (14%)               3/28 (11%)               4/29 (14%)               1/26 (4%)       | 
|FIRST INCIDENCE    |                  729 (T)                  709                      703                      672             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.326N                 P=0.619                  P=0.498                  P=0.386N        | 
|POLY 3             |                  P=0.278N                 P=0.641N                 P=0.521                  P=0.338N        | 
|POLY 1.5           |                  P=0.276N                 P=0.639N                 P=0.515                  P=0.335N        | 
|POLY 6             |                  P=0.288N                 P=0.641                  P=0.522                  P=0.348N        | 
|LOGISTIC REGRESSION|                  P=0.312N                 P=0.605                  P=0.504                  P=0.369N        | 
|COCH-ARM / FISHERS |                  P=0.278N                 P=0.643N                 P=0.500                  P=0.339N        | 
|ORDER RESTRICTED   |                  P=0.307N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  33/50 (66%)              25/50 (50%)              24/50 (48%)              17/50 (34%)     | 
|POLY-3 RATE (b)    |                  33/45.53                 25/44.29                 24/44.93                 17/43.23        | 
|POLY-3 PERCENT (g) |                  72.5%                    56.5%                    53.4%                    39.3%           | 
|TERMINAL (d)       |                  26/29 (90%)              21/28 (75%)              18/29 (62%)              15/26 (58%)     | 
|FIRST INCIDENCE    |                  459                      526                      642                      486             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.003N**               P=0.082N                 P=0.048N*                P=0.002N**      | 
|POLY 3             |                  P<0.001N**               P=0.074N                 P=0.040N*                P<0.001N**      | 
|POLY 1.5           |                  P<0.001N**               P=0.072N                 P=0.042N*                P<0.001N**      | 
|POLY 6             |                  P<0.001N**               P=0.081N                 P=0.039N*                P<0.001N**      | 
|LOGISTIC REGRESSION|                  P<0.001N**               P=0.061N                 P=0.027N*                P<0.001N**      | 
|COCH-ARM / FISHERS |                  P<0.001N**               P=0.078N                 P=0.053N                 P<0.001N**      | 
|ORDER RESTRICTED   |                  P<0.001N**               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Cholangiofibrosis                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                2/50 (4%)                1/50 (2%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  1/42.79                  2/42.97                  1/44.78                  1/42.45         | 
|POLY-3 PERCENT (g) |                  2.3%                     4.7%                     2.2%                     2.4%            | 
|TERMINAL (d)       |                  1/29 (3%)                2/28 (7%)                0/29 (0%)                1/26 (4%)       | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  526                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.556N                 P=0.488                  P=0.753N                 P=0.738         | 
|POLY 3             |                  P=0.530N                 P=0.501                  P=0.751N                 P=0.759         | 
|POLY 1.5           |                  P=0.528N                 P=0.502                  P=0.753N                 P=0.760N        | 
|POLY 6             |                  P=0.536N                 P=0.497                  P=0.750N                 P=0.753         | 
|LOGISTIC REGRESSION|                  P=0.530N                 P=0.488                  P=0.728                  P=0.738         | 
|COCH-ARM / FISHERS |                  P=0.531N                 P=0.500                  P=0.753N                 P=0.753N        | 
|ORDER RESTRICTED   |                  P=0.581N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  28/50 (56%)              24/50 (48%)              19/50 (38%)              17/50 (34%)     | 
|POLY-3 RATE (b)    |                  28/43.00                 24/43.88                 19/44.15                 17/42.86        | 
|POLY-3 PERCENT (g) |                  65.1%                    54.7%                    43.0%                    39.7%           | 
|TERMINAL (d)       |                  25/29 (86%)              22/28 (79%)              19/29 (66%)              15/26 (58%)     | 
|FIRST INCIDENCE    |                  709                      526                      729 (T)                  637             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.010N*                P=0.291N                 P=0.016N*                P=0.030N*       | 
|POLY 3             |                  P=0.007N**               P=0.208N                 P=0.025N*                P=0.011N*       | 
|POLY 1.5           |                  P=0.009N**               P=0.228N                 P=0.033N*                P=0.013N*       | 
|POLY 6             |                  P=0.007N**               P=0.200N                 P=0.020N*                P=0.010N*       | 
|LOGISTIC REGRESSION|                  P=0.015N*                P=0.312N                 P=0.016N*                P=0.032N*       | 
|COCH-ARM / FISHERS |                  P=0.013N*                P=0.274N                 P=0.054N                 P=0.022N*       | 
|ORDER RESTRICTED   |                  P=0.009N**               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                1/50 (2%)                1/50 (2%)                4/50 (8%)       | 
|POLY-3 RATE (b)    |                  2/42.84                  1/42.97                  1/44.26                  4/42.88         | 
|POLY-3 PERCENT (g) |                  4.7%                     2.3%                     2.3%                     9.3%            | 
|TERMINAL (d)       |                  1/29 (3%)                1/28 (4%)                0/29 (0%)                1/26 (4%)       | 
|FIRST INCIDENCE    |                  718                      729 (T)                  703                      672             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.140                  P=0.524N                 P=0.503N                 P=0.287         | 
|POLY 3             |                  P=0.165                  P=0.499N                 P=0.489N                 P=0.337         | 
|POLY 1.5           |                  P=0.166                  P=0.498N                 P=0.492N                 P=0.340         | 
|POLY 6             |                  P=0.162                  P=0.504N                 P=0.489N                 P=0.328         | 
|LOGISTIC REGRESSION|                  P=0.156                  P=0.522N                 P=0.491N                 P=0.325         | 
|COCH-ARM / FISHERS |                  P=0.165                  P=0.500N                 P=0.500N                 P=0.339         | 
|ORDER RESTRICTED   |                  P=0.131                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Degeneration Cystic Focal                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  31/50 (62%)              24/50 (48%)              23/50 (46%)              29/50 (58%)     | 
|POLY-3 RATE (b)    |                  31/43.97                 24/45.18                 23/45.49                 29/45.16        | 
|POLY-3 PERCENT (g) |                  70.5%                    53.1%                    50.6%                    64.2%           | 
|TERMINAL (d)       |                  24/29 (83%)              18/28 (64%)              16/29 (55%)              19/26 (73%)     | 
|FIRST INCIDENCE    |                  620                      556                      628                      554             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.398                  P=0.150N                 P=0.085N                 P=0.502         | 
|POLY 3             |                  P=0.444N                 P=0.061N                 P=0.036N*                P=0.334N        | 
|POLY 1.5           |                  P=0.456N                 P=0.076N                 P=0.048N*                P=0.359N        | 
|POLY 6             |                  P=0.443N                 P=0.052N                 P=0.028N*                P=0.328N        | 
|LOGISTIC REGRESSION|                  P=0.517N                 P=0.095N                 P=0.041N*                P=0.458N        | 
|COCH-ARM / FISHERS |                  P=0.490N                 P=0.114N                 P=0.080N                 P=0.419N        | 
|ORDER RESTRICTED   |                  P=0.110N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                1/50 (2%)                4/50 (8%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  0/42.79                  1/42.97                  4/44.23                  0/42.45         | 
|POLY-3 PERCENT (g) |                  0.0%                     2.3%                     9.0%                     0.0%            | 
|TERMINAL (d)       |                  0/29 (0%)                1/28 (4%)                3/29 (10%)               0/26 (0%)       | 
|FIRST INCIDENCE    |                  ---                      729 (T)                  709                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.558                  P=0.493                  P=0.062                  (e)             | 
|POLY 3             |                  P=0.583                  P=0.501                  P=0.064                  (e)             | 
|POLY 1.5           |                  P=0.591                  P=0.501                  P=0.063                  (e)             | 
|POLY 6             |                  P=0.564                  P=0.498                  P=0.064                  (e)             | 
|LOGISTIC REGRESSION|                  P=0.562                  P=0.493                  P=0.063                  (e)             | 
|COCH-ARM / FISHERS |                  P=0.591                  P=0.500                  P=0.059                  (e)             | 
|ORDER RESTRICTED   |                  P=0.155                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fibrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                1/50 (2%)                1/50 (2%)                3/50 (6%)       | 
|POLY-3 RATE (b)    |                  1/42.79                  1/42.97                  1/44.15                  3/43.48         | 
|POLY-3 PERCENT (g) |                  2.3%                     2.3%                     2.3%                     6.9%            | 
|TERMINAL (d)       |                  1/29 (3%)                1/28 (4%)                1/29 (3%)                1/26 (4%)       | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  729 (T)                  485             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.148                  P=0.754                  P=0.762                  P=0.292         | 
|POLY 3             |                  P=0.168                  P=0.760N                 P=0.754N                 P=0.311         | 
|POLY 1.5           |                  P=0.167                  P=0.759N                 P=0.755N                 P=0.311         | 
|POLY 6             |                  P=0.165                  P=0.759                  P=0.754N                 P=0.305         | 
|LOGISTIC REGRESSION|                  P=0.161                  P=0.754                  P=0.762                  P=0.286         | 
|COCH-ARM / FISHERS |                  P=0.163                  P=0.753N                 P=0.753N                 P=0.309         | 
|ORDER RESTRICTED   |                  P=0.192                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  5/50 (10%)               5/50 (10%)               12/50 (24%)              4/50 (8%)       | 
|POLY-3 RATE (b)    |                  5/43.24                  5/43.76                  12/46.20                 4/43.18         | 
|POLY-3 PERCENT (g) |                  11.6%                    11.4%                    26.0%                    9.3%            | 
|TERMINAL (d)       |                  3/29 (10%)               2/28 (7%)                6/29 (21%)               2/26 (8%)       | 
|FIRST INCIDENCE    |                  610                      624                      430                      486             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.524                  P=0.612                  P=0.069                  P=0.551N        | 
|POLY 3             |                  P=0.533N                 P=0.623N                 P=0.069                  P=0.501N        | 
|POLY 1.5           |                  P=0.524N                 P=0.623N                 P=0.064                  P=0.496N        | 
|POLY 6             |                  P=0.553                  P=0.628N                 P=0.072                  P=0.518N        | 
|LOGISTIC REGRESSION|                  P=0.531N                 P=0.628N                 P=0.052                  P=0.499N        | 
|COCH-ARM / FISHERS |                  P=0.528N                 P=0.630N                 P=0.054                  P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.270N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Infiltration Cellular Mixed Cell                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  30/50 (60%)              31/50 (62%)              34/50 (68%)              34/50 (68%)     | 
|POLY-3 RATE (b)    |                  30/46.17                 31/47.01                 34/48.03                 34/47.45        | 
|POLY-3 PERCENT (g) |                  65.0%                    66.0%                    70.8%                    71.7%           | 
|TERMINAL (d)       |                  22/29 (76%)              21/28 (75%)              21/29 (72%)              18/26 (69%)     | 
|FIRST INCIDENCE    |                  354                      498                      430                      448             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.129                  P=0.446                  P=0.317                  P=0.164         | 
|POLY 3             |                  P=0.243                  P=0.549                  P=0.347                  P=0.312         | 
|POLY 1.5           |                  P=0.233                  P=0.529                  P=0.316                  P=0.299         | 
|POLY 6             |                  P=0.243                  P=0.569                  P=0.382                  P=0.316         | 
|LOGISTIC REGRESSION|                  P=0.207                  P=0.511                  P=0.286                  P=0.269         | 
|COCH-ARM / FISHERS |                  P=0.205                  P=0.500                  P=0.266                  P=0.266         | 
|ORDER RESTRICTED   |                  P=0.378                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 16      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  23/50 (46%)              29/50 (58%)              33/50 (66%)              34/50 (68%)     | 
|POLY-3 RATE (b)    |                  23/44.55                 29/46.18                 33/46.05                 34/46.72        | 
|POLY-3 PERCENT (g) |                  51.6%                    62.8%                    71.7%                    72.8%           | 
|TERMINAL (d)       |                  20/29 (69%)              21/28 (75%)              24/29 (83%)              22/26 (85%)     | 
|FIRST INCIDENCE    |                  459                      498                      526                      448             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.005 **               P=0.121                  P=0.032 *                P=0.006 **      | 
|POLY 3             |                  P=0.018 *                P=0.187                  P=0.033 *                P=0.024 *       | 
|POLY 1.5           |                  P=0.019 *                P=0.177                  P=0.034 *                P=0.024 *       | 
|POLY 6             |                  P=0.014 *                P=0.194                  P=0.030 *                P=0.019 *       | 
|LOGISTIC REGRESSION|                  P=0.016 *                P=0.163                  P=0.045 *                P=0.021 *       | 
|COCH-ARM / FISHERS |                  P=0.017 *                P=0.158                  P=0.035 *                P=0.021 *       | 
|ORDER RESTRICTED   |                  P=0.017 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                3/50 (6%)                10/50 (20%)              4/50 (8%)       | 
|POLY-3 RATE (b)    |                  0/42.79                  3/42.97                  10/44.62                 4/42.61         | 
|POLY-3 PERCENT (g) |                  0.0%                     7.0%                     22.4%                    9.4%            | 
|TERMINAL (d)       |                  0/29 (0%)                3/28 (11%)               7/29 (24%)               3/26 (12%)      | 
|FIRST INCIDENCE    |                  ---                      729 (T)                  667                      686             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.057                  P=0.114                  P=0.002 **               P=0.053         | 
|POLY 3             |                  P=0.069                  P=0.119                  P<0.001 **               P=0.059         | 
|POLY 1.5           |                  P=0.073                  P=0.120                  P<0.001 **               P=0.061         | 
|POLY 6             |                  P=0.060                  P=0.116                  P<0.001 **               P=0.056         | 
|LOGISTIC REGRESSION|                  P=0.061                  P=0.114                  P<0.001 **               P=0.053         | 
|COCH-ARM / FISHERS |                  P=0.079                  P=0.121                  P<0.001 **               P=0.059         | 
|ORDER RESTRICTED   |                  P=0.007 **               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 17      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                0/50 (0%)                0/50 (0%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  2/44.43                  0/42.97                  0/44.15                  1/42.45         | 
|POLY-3 PERCENT (g) |                  4.5%                     0.0%                     0.0%                     2.4%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/28 (0%)                0/29 (0%)                1/26 (4%)       | 
|FIRST INCIDENCE    |                  354                      ---                      ---                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.468N                 P=0.237N                 P=0.237N                 P=0.510N        | 
|POLY 3             |                  P=0.454N                 P=0.245N                 P=0.238N                 P=0.516N        | 
|POLY 1.5           |                  P=0.457N                 P=0.241N                 P=0.238N                 P=0.508N        | 
|POLY 6             |                  P=0.450N                 P=0.250N                 P=0.241N                 P=0.529N        | 
|LOGISTIC REGRESSION|                  P=0.628N                 P=0.450N                 P=0.605N                 P=0.682N        | 
|COCH-ARM / FISHERS |                  P=0.461N                 P=0.247N                 P=0.247N                 P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.141N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  45/50 (90%)              49/50 (98%)              49/50 (98%)              50/50 (100%)    | 
|POLY-3 RATE (b)    |                  45/47.87                 49/50.00                 49/50.00                 50/50.00        | 
|POLY-3 PERCENT (g) |                  94.0%                    98.0%                    98.0%                    100.0%          | 
|TERMINAL (d)       |                  28/29 (97%)              27/28 (96%)              28/29 (97%)              26/26 (100%)    | 
|FIRST INCIDENCE    |                  459                      405                      430                      448             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.112                  P=0.247                  P=0.338                  P=0.104         | 
|POLY 3             |                  P=0.068                  P=0.299                  P=0.299                  P=0.100         | 
|POLY 1.5           |                  P=0.038 *                P=0.205                  P=0.205                  P=0.059         | 
|POLY 6             |                  P=0.106                  P=0.396                  P=0.396                  P=0.155         | 
|LOGISTIC REGRESSION|                  P=0.022 *                P=0.127                  P=0.164                  P=0.045 *       | 
|COCH-ARM / FISHERS |                  P=0.016 *                P=0.102                  P=0.102                  P=0.028 *       | 
|ORDER RESTRICTED   |                  P=0.030 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 18      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Fatty Change                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  36/50 (72%)              34/50 (68%)              36/50 (72%)              40/50 (80%)     | 
|POLY-3 RATE (b)    |                  36/47.08                 34/47.41                 36/47.46                 40/48.57        | 
|POLY-3 PERCENT (g) |                  76.5%                    71.7%                    75.9%                    82.4%           | 
|TERMINAL (d)       |                  24/29 (83%)              19/28 (68%)              23/29 (79%)              21/26 (81%)     | 
|FIRST INCIDENCE    |                  405                      405                      548                      448             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.110                  P=0.498N                 P=0.545N                 P=0.161         | 
|POLY 3             |                  P=0.198                  P=0.382N                 P=0.570N                 P=0.317         | 
|POLY 1.5           |                  P=0.182                  P=0.384N                 P=0.572N                 P=0.293         | 
|POLY 6             |                  P=0.214                  P=0.393N                 P=0.573N                 P=0.337         | 
|LOGISTIC REGRESSION|                  P=0.158                  P=0.399N                 P=0.524N                 P=0.247         | 
|COCH-ARM / FISHERS |                  P=0.153                  P=0.414N                 P=0.588N                 P=0.241         | 
|ORDER RESTRICTED   |                  P=0.255                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  11/50 (22%)              10/50 (20%)              19/50 (38%)              18/50 (36%)     | 
|POLY-3 RATE (b)    |                  11/45.09                 10/44.80                 19/45.17                 18/45.46        | 
|POLY-3 PERCENT (g) |                  24.4%                    22.3%                    42.1%                    39.6%           | 
|TERMINAL (d)       |                  2/29 (7%)                3/28 (11%)               16/29 (55%)              10/26 (39%)     | 
|FIRST INCIDENCE    |                  553                      405                      526                      448             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.026 *                P=0.526N                 P=0.082                  P=0.083         | 
|POLY 3             |                  P=0.030 *                P=0.507N                 P=0.056                  P=0.090         | 
|POLY 1.5           |                  P=0.032 *                P=0.497N                 P=0.061                  P=0.095         | 
|POLY 6             |                  P=0.024 *                P=0.533N                 P=0.045 *                P=0.075         | 
|LOGISTIC REGRESSION|                  P=0.033 *                P=0.512N                 P=0.070                  P=0.090         | 
|COCH-ARM / FISHERS |                  P=0.033 *                P=0.500N                 P=0.063                  P=0.093         | 
|ORDER RESTRICTED   |                  P=0.049 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 19      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte, Centrilobular                                                                                                 | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                1/50 (2%)                1/50 (2%)                4/50 (8%)       | 
|POLY-3 RATE (b)    |                  1/43.18                  1/43.15                  1/44.78                  4/43.59         | 
|POLY-3 PERCENT (g) |                  2.3%                     2.3%                     2.2%                     9.2%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/28 (0%)                0/29 (0%)                1/26 (4%)       | 
|FIRST INCIDENCE    |                  620                      681                      526                      485             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.066                  P=0.758N                 P=0.748N                 P=0.178         | 
|POLY 3             |                  P=0.068                  P=0.761                  P=0.753N                 P=0.181         | 
|POLY 1.5           |                  P=0.068                  P=0.760N                 P=0.755N                 P=0.182         | 
|POLY 6             |                  P=0.067                  P=0.757                  P=0.753N                 P=0.175         | 
|LOGISTIC REGRESSION|                  P=0.052                  P=0.755                  P=0.683                  P=0.156         | 
|COCH-ARM / FISHERS |                  P=0.067                  P=0.753N                 P=0.753N                 P=0.181         | 
|ORDER RESTRICTED   |                  P=0.076                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  4/50 (8%)                1/50 (2%)                3/50 (6%)                5/50 (10%)      | 
|POLY-3 RATE (b)    |                  4/44.66                  1/43.25                  3/44.83                  5/43.93         | 
|POLY-3 PERCENT (g) |                  9.0%                     2.3%                     6.7%                     11.4%           | 
|TERMINAL (d)       |                  0/29 (0%)                0/28 (0%)                1/29 (3%)                0/26 (0%)       | 
|FIRST INCIDENCE    |                  405                      651                      548                      486             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.247                  P=0.187N                 P=0.489N                 P=0.470         | 
|POLY 3             |                  P=0.265                  P=0.188N                 P=0.498N                 P=0.490         | 
|POLY 1.5           |                  P=0.266                  P=0.184N                 P=0.497N                 P=0.496         | 
|POLY 6             |                  P=0.261                  P=0.196N                 P=0.503N                 P=0.476         | 
|LOGISTIC REGRESSION|                  P=0.210                  P=0.223N                 P=0.639N                 P=0.422         | 
|COCH-ARM / FISHERS |                  P=0.264                  P=0.181N                 P=0.500N                 P=0.500         | 
|ORDER RESTRICTED   |                  P=0.241                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 20      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage Focal                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                1/50 (2%)                2/50 (4%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  3/42.82                  1/43.34                  2/44.15                  2/42.78         | 
|POLY-3 PERCENT (g) |                  7.0%                     2.3%                     4.5%                     4.7%            | 
|TERMINAL (d)       |                  2/29 (7%)                0/28 (0%)                2/29 (7%)                1/26 (4%)       | 
|FIRST INCIDENCE    |                  722                      624                      729 (T)                  636             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.530N                 P=0.319N                 P=0.500N                 P=0.542N        | 
|POLY 3             |                  P=0.501N                 P=0.301N                 P=0.486N                 P=0.500N        | 
|POLY 1.5           |                  P=0.499N                 P=0.301N                 P=0.489N                 P=0.497N        | 
|POLY 6             |                  P=0.506N                 P=0.303N                 P=0.487N                 P=0.510N        | 
|LOGISTIC REGRESSION|                  P=0.503N                 P=0.304N                 P=0.498N                 P=0.512N        | 
|COCH-ARM / FISHERS |                  P=0.500N                 P=0.309N                 P=0.500N                 P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.389N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                1/50 (2%)                0/50 (0%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  1/43.54                  1/43.60                  0/44.15                  2/43.85         | 
|POLY-3 PERCENT (g) |                  2.3%                     2.3%                     0.0%                     4.6%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/28 (0%)                0/29 (0%)                0/26 (0%)       | 
|FIRST INCIDENCE    |                  459                      520                      ---                      485             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.375                  P=0.753N                 P=0.496N                 P=0.515         | 
|POLY 3             |                  P=0.369                  P=0.760N                 P=0.497N                 P=0.502         | 
|POLY 1.5           |                  P=0.369                  P=0.760N                 P=0.497N                 P=0.504         | 
|POLY 6             |                  P=0.365                  P=0.759                  P=0.499N                 P=0.496         | 
|LOGISTIC REGRESSION|                  P=0.155                  P=0.665                  P=0.729N                 P=0.243         | 
|COCH-ARM / FISHERS |                  P=0.366                  P=0.753N                 P=0.500N                 P=0.500         | 
|ORDER RESTRICTED   |                  P=0.273                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 21      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Infiltration Cellular Mixed Cell                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                0/50 (0%)                0/50 (0%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  2/42.79                  0/42.97                  0/44.15                  1/42.58         | 
|POLY-3 PERCENT (g) |                  4.7%                     0.0%                     0.0%                     2.4%            | 
|TERMINAL (d)       |                  2/29 (7%)                0/28 (0%)                0/29 (0%)                0/26 (0%)       | 
|FIRST INCIDENCE    |                  729 (T)                  ---                      ---                      695             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.487N                 P=0.246N                 P=0.238N                 P=0.539N        | 
|POLY 3             |                  P=0.459N                 P=0.236N                 P=0.230N                 P=0.502N        | 
|POLY 1.5           |                  P=0.460N                 P=0.236N                 P=0.232N                 P=0.499N        | 
|POLY 6             |                  P=0.455N                 P=0.239N                 P=0.230N                 P=0.510N        | 
|LOGISTIC REGRESSION|                  P=0.474N                 (e)                      (e)                      P=0.522N        | 
|COCH-ARM / FISHERS |                  P=0.461N                 P=0.247N                 P=0.247N                 P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.131N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Chronic Focal                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                2/50 (4%)                3/50 (6%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  0/42.79                  2/42.97                  3/44.39                  2/42.45         | 
|POLY-3 PERCENT (g) |                  0.0%                     4.7%                     6.8%                     4.7%            | 
|TERMINAL (d)       |                  0/29 (0%)                2/28 (7%)                1/29 (3%)                2/26 (8%)       | 
|FIRST INCIDENCE    |                  ---                      729 (T)                  697                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.204                  P=0.230                  P=0.122                  P=0.214         | 
|POLY 3             |                  P=0.233                  P=0.238                  P=0.125                  P=0.235         | 
|POLY 1.5           |                  P=0.238                  P=0.239                  P=0.123                  P=0.237         | 
|POLY 6             |                  P=0.220                  P=0.234                  P=0.125                  P=0.229         | 
|LOGISTIC REGRESSION|                  P=0.213                  P=0.230                  P=0.125                  P=0.214         | 
|COCH-ARM / FISHERS |                  P=0.237                  P=0.247                  P=0.121                  P=0.247         | 
|ORDER RESTRICTED   |                  P=0.140                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 22      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  7/50 (14%)               6/50 (12%)               9/50 (18%)               5/50 (10%)      | 
|POLY-3 RATE (b)    |                  7/43.44                  6/43.45                  9/44.68                  5/42.61         | 
|POLY-3 PERCENT (g) |                  16.1%                    13.8%                    20.1%                    11.7%           | 
|TERMINAL (d)       |                  4/29 (14%)               3/28 (11%)               6/29 (21%)               4/26 (15%)      | 
|FIRST INCIDENCE    |                  651                      681                      649                      686             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.459N                 P=0.523N                 P=0.394                  P=0.459N        | 
|POLY 3             |                  P=0.390N                 P=0.500N                 P=0.415                  P=0.392N        | 
|POLY 1.5           |                  P=0.379N                 P=0.496N                 P=0.411                  P=0.382N        | 
|POLY 6             |                  P=0.417N                 P=0.512N                 P=0.412                  P=0.417N        | 
|LOGISTIC REGRESSION|                  P=0.394N                 P=0.499N                 P=0.417                  P=0.400N        | 
|COCH-ARM / FISHERS |                  P=0.376N                 P=0.500N                 P=0.393                  P=0.380N        | 
|ORDER RESTRICTED   |                  P=0.415N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                0/49 (0%)                0/50 (0%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  2/43.18                  0/42.10                  0/44.15                  1/42.45         | 
|POLY-3 PERCENT (g) |                  4.6%                     0.0%                     0.0%                     2.4%            | 
|TERMINAL (d)       |                  1/29 (3%)                0/28 (0%)                0/29 (0%)                1/26 (4%)       | 
|FIRST INCIDENCE    |                  620                      ---                      ---                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.478N                 P=0.241N                 P=0.235N                 P=0.525N        | 
|POLY 3             |                  P=0.456N                 P=0.243N                 P=0.232N                 P=0.506N        | 
|POLY 1.5           |                  P=0.458N                 P=0.241N                 P=0.233N                 P=0.501N        | 
|POLY 6             |                  P=0.452N                 P=0.247N                 P=0.233N                 P=0.518N        | 
|LOGISTIC REGRESSION|                  P=0.459N                 P=0.243N                 P=0.243N                 P=0.500N        | 
|COCH-ARM / FISHERS |                  P=0.459N                 P=0.253N                 P=0.247N                 P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.135N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 23      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                2/49 (4%)                0/50 (0%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  0/42.79                  2/42.10                  0/44.15                  1/42.45         | 
|POLY-3 PERCENT (g) |                  0.0%                     4.8%                     0.0%                     2.4%            | 
|TERMINAL (d)       |                  0/29 (0%)                2/28 (7%)                0/29 (0%)                1/26 (4%)       | 
|FIRST INCIDENCE    |                  ---                      729 (T)                  ---                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.514                  P=0.230                  (e)                      P=0.478         | 
|POLY 3             |                  P=0.540                  P=0.233                  (e)                      P=0.498         | 
|POLY 1.5           |                  P=0.543                  P=0.234                  (e)                      P=0.500         | 
|POLY 6             |                  P=0.530                  P=0.230                  (e)                      P=0.493         | 
|LOGISTIC REGRESSION|                  (e)                      P=0.230                  (e)                      P=0.478         | 
|COCH-ARM / FISHERS |                  P=0.541                  P=0.242                  (e)                      P=0.500         | 
|ORDER RESTRICTED   |                  P=0.323                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/25 (8%)                0/28 (0%)                0/26 (0%)                1/26 (4%)       | 
|POLY-3 RATE (b)    |                  2/22.00                  0/24.43                  0/22.94                  1/21.69         | 
|POLY-3 PERCENT (g) |                  9.1%                     0.0%                     0.0%                     4.6%            | 
|TERMINAL (d)       |                  0/11 (0%)                0/16 (0%)                0/14 (0%)                0/11 (0%)       | 
|FIRST INCIDENCE    |                  354                      ---                      ---                      448             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.457N                 P=0.237N                 P=0.237N                 P=0.493N        | 
|POLY 3             |                  P=0.455N                 P=0.211N                 P=0.225N                 P=0.505N        | 
|POLY 1.5           |                  P=0.456N                 P=0.211N                 P=0.225N                 P=0.496N        | 
|POLY 6             |                  P=0.451N                 P=0.209N                 P=0.223N                 P=0.523N        | 
|LOGISTIC REGRESSION|                  P=0.579                  P=0.334N                 (e)                      (e)             | 
|COCH-ARM / FISHERS |                  P=0.459N                 P=0.218N                 P=0.235N                 P=0.485N        | 
|ORDER RESTRICTED   |                  P=0.127N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 24      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/25 (12%)               1/28 (4%)                3/26 (12%)               4/26 (15%)      | 
|POLY-3 RATE (b)    |                  3/20.36                  1/24.43                  3/22.94                  4/21.25         | 
|POLY-3 PERCENT (g) |                  14.7%                    4.1%                     13.1%                    18.8%           | 
|TERMINAL (d)       |                  3/11 (27%)               1/16 (6%)                3/14 (21%)               3/11 (27%)      | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  729 (T)                  637             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.214                  P=0.173N                 P=0.551N                 P=0.498         | 
|POLY 3             |                  P=0.262                  P=0.237N                 P=0.610N                 P=0.524         | 
|POLY 1.5           |                  P=0.272                  P=0.247N                 P=0.623N                 P=0.528         | 
|POLY 6             |                  P=0.243                  P=0.227N                 P=0.597N                 P=0.509         | 
|LOGISTIC REGRESSION|                  P=0.195                  P=0.173N                 P=0.551N                 P=0.452         | 
|COCH-ARM / FISHERS |                  P=0.277                  P=0.263N                 P=0.647N                 P=0.523         | 
|ORDER RESTRICTED   |                  P=0.277                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/25 (0%)                0/28 (0%)                1/26 (4%)                2/26 (8%)       | 
|POLY-3 RATE (b)    |                  0/20.36                  0/24.43                  1/23.16                  2/21.85         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     4.3%                     9.2%            | 
|TERMINAL (d)       |                  0/11 (0%)                0/16 (0%)                0/14 (0%)                0/11 (0%)       | 
|FIRST INCIDENCE    |                  ---                      ---                      669                      448             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.067                  (e)                      P=0.500                  P=0.238         | 
|POLY 3             |                  P=0.067                  (e)                      P=0.526                  P=0.250         | 
|POLY 1.5           |                  P=0.068                  (e)                      P=0.519                  P=0.250         | 
|POLY 6             |                  P=0.063                  (e)                      P=0.533                  P=0.245         | 
|LOGISTIC REGRESSION|                  P=0.056                  (e)                      P=0.498                  P=0.179         | 
|COCH-ARM / FISHERS |                  P=0.067                  (e)                      P=0.510                  P=0.255         | 
|ORDER RESTRICTED   |                  P=0.082                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 25      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/25 (12%)               4/28 (14%)               6/26 (23%)               3/26 (12%)      | 
|POLY-3 RATE (b)    |                  3/21.25                  4/25.11                  6/23.64                  3/21.40         | 
|POLY-3 PERCENT (g) |                  14.1%                    15.9%                    25.4%                    14.0%           | 
|TERMINAL (d)       |                  2/11 (18%)               2/16 (13%)               4/14 (29%)               1/11 (9%)       | 
|FIRST INCIDENCE    |                  354                      556                      548                      633             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.526                  P=0.614                  P=0.326                  P=0.657         | 
|POLY 3             |                  P=0.538                  P=0.594                  P=0.286                  P=0.665N        | 
|POLY 1.5           |                  P=0.557                  P=0.580                  P=0.272                  P=0.656N        | 
|POLY 6             |                  P=0.505                  P=0.613                  P=0.305                  P=0.659         | 
|LOGISTIC REGRESSION|                  P=0.571N                 P=0.513                  P=0.211                  P=0.662N        | 
|COCH-ARM / FISHERS |                  P=0.571N                 P=0.566                  P=0.253                  P=0.647N        | 
|ORDER RESTRICTED   |                  P=0.495                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/25 (12%)               5/28 (18%)               3/26 (12%)               5/26 (19%)      | 
|POLY-3 RATE (b)    |                  3/20.36                  5/25.45                  3/23.02                  5/20.92         | 
|POLY-3 PERCENT (g) |                  14.7%                    19.7%                    13.0%                    23.9%           | 
|TERMINAL (d)       |                  3/11 (27%)               2/16 (13%)               1/14 (7%)                5/11 (46%)      | 
|FIRST INCIDENCE    |                  729 (T)                  556                      709                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.296                  P=0.486                  P=0.588N                 P=0.333         | 
|POLY 3             |                  P=0.336                  P=0.483                  P=0.608N                 P=0.363         | 
|POLY 1.5           |                  P=0.352                  P=0.457                  P=0.622N                 P=0.373         | 
|POLY 6             |                  P=0.304                  P=0.516                  P=0.593N                 P=0.335         | 
|LOGISTIC REGRESSION|                  P=0.312                  P=0.436                  P=0.554N                 P=0.333         | 
|COCH-ARM / FISHERS |                  P=0.358                  P=0.419                  P=0.647N                 P=0.374         | 
|ORDER RESTRICTED   |                  P=0.366                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 26      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/25 (4%)                0/28 (0%)                2/26 (8%)                1/26 (4%)       | 
|POLY-3 RATE (b)    |                  1/21.11                  0/24.43                  2/22.94                  1/20.92         | 
|POLY-3 PERCENT (g) |                  4.7%                     0.0%                     8.7%                     4.8%            | 
|TERMINAL (d)       |                  0/11 (0%)                0/16 (0%)                2/14 (14%)               1/11 (9%)       | 
|FIRST INCIDENCE    |                  459                      ---                      729 (T)                  729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.476                  P=0.496N                 P=0.559                  P=0.758N        | 
|POLY 3             |                  P=0.471                  P=0.471N                 P=0.529                  P=0.760         | 
|POLY 1.5           |                  P=0.487                  P=0.473N                 P=0.524                  P=0.757N        | 
|POLY 6             |                  P=0.443                  P=0.468N                 P=0.534                  P=0.748         | 
|LOGISTIC REGRESSION|                  P=0.498                  P=0.628N                 P=0.447                  P=0.747         | 
|COCH-ARM / FISHERS |                  P=0.501                  P=0.472N                 P=0.515                  P=0.745N        | 
|ORDER RESTRICTED   |                  P=0.383                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/25 (12%)               7/28 (25%)               0/26 (0%)                5/26 (19%)      | 
|POLY-3 RATE (b)    |                  3/21.11                  7/24.43                  0/22.94                  5/21.33         | 
|POLY-3 PERCENT (g) |                  14.2%                    28.7%                    0.0%                     23.4%           | 
|TERMINAL (d)       |                  2/11 (18%)               7/16 (44%)               0/14 (0%)                3/11 (27%)      | 
|FIRST INCIDENCE    |                  459                      729 (T)                  ---                      637             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.457                  P=0.309                  P=0.093N                 P=0.339         | 
|POLY 3             |                  P=0.513                  P=0.206                  P=0.098N                 P=0.354         | 
|POLY 1.5           |                  P=0.520                  P=0.203                  P=0.101N                 P=0.366         | 
|POLY 6             |                  P=0.499                  P=0.210                  P=0.095N                 P=0.329         | 
|LOGISTIC REGRESSION|                  P=0.496                  P=0.225                  P=0.133N                 P=0.372         | 
|COCH-ARM / FISHERS |                  P=0.522                  P=0.197                  P=0.110N                 P=0.374         | 
|ORDER RESTRICTED   |                  P=0.279N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 27      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  8/44 (18%)               18/45 (40%)              16/47 (34%)              12/42 (29%)     | 
|POLY-3 RATE (b)    |                  8/40.17                  18/40.66                 16/43.49                 12/37.23        | 
|POLY-3 PERCENT (g) |                  19.9%                    44.3%                    36.8%                    32.2%           | 
|TERMINAL (d)       |                  3/27 (11%)               9/26 (35%)               6/27 (22%)               4/20 (20%)      | 
|FIRST INCIDENCE    |                  526                      620                      548                      605             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.246                  P=0.027 *                P=0.078                  P=0.152         | 
|POLY 3             |                  P=0.290                  P=0.015 *                P=0.069                  P=0.163         | 
|POLY 1.5           |                  P=0.314                  P=0.017 *                P=0.070                  P=0.177         | 
|POLY 6             |                  P=0.248                  P=0.014 *                P=0.067                  P=0.141         | 
|LOGISTIC REGRESSION|                  P=0.331                  P=0.021 *                P=0.066                  P=0.192         | 
|COCH-ARM / FISHERS |                  P=0.332                  P=0.021 *                P=0.069                  P=0.188         | 
|ORDER RESTRICTED   |                  P=0.071                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/44 (5%)                3/45 (7%)                2/47 (4%)                1/42 (2%)       | 
|POLY-3 RATE (b)    |                  2/38.47                  3/38.66                  2/41.23                  1/35.29         | 
|POLY-3 PERCENT (g) |                  5.2%                     7.8%                     4.9%                     2.8%            | 
|TERMINAL (d)       |                  2/27 (7%)                3/26 (12%)               2/27 (7%)                1/20 (5%)       | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  729 (T)                  729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.417N                 P=0.482                  P=0.697                  P=0.605N        | 
|POLY 3             |                  P=0.341N                 P=0.502                  P=0.669N                 P=0.530N        | 
|POLY 1.5           |                  P=0.333N                 P=0.507                  P=0.668N                 P=0.522N        | 
|POLY 6             |                  P=0.358N                 P=0.494                  P=0.675N                 P=0.548N        | 
|LOGISTIC REGRESSION|                  P=0.417N                 P=0.482                  P=0.697                  P=0.605N        | 
|COCH-ARM / FISHERS |                  P=0.327N                 P=0.511                  P=0.666N                 P=0.518N        | 
|ORDER RESTRICTED   |                  P=0.392N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 28      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  8/15 (53%)               4/13 (31%)               9/14 (64%)               7/15 (47%)      | 
|POLY-3 RATE (b)    |                  8/14.60                  4/11.24                  9/12.44                  7/12.93         | 
|POLY-3 PERCENT (g) |                  54.8%                    35.6%                    72.3%                    54.2%           | 
|TERMINAL (d)       |                  6/9 (67%)                4/6 (67%)                3/4 (75%)                5/7 (71%)       | 
|FIRST INCIDENCE    |                  526                      729 (T)                  548                      605             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.338                  P=0.334N                 P=0.152                  P=0.596         | 
|POLY 3             |                  P=0.427                  P=0.284N                 P=0.292                  P=0.637N        | 
|POLY 1.5           |                  P=0.488                  P=0.253N                 P=0.343                  P=0.572N        | 
|POLY 6             |                  P=0.322                  P=0.329N                 P=0.232                  P=0.572         | 
|LOGISTIC REGRESSION|                  P=0.487                  P=0.213N                 P=0.431                  P=0.520N        | 
|COCH-ARM / FISHERS |                  P=0.543                  P=0.207N                 P=0.413                  P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.277                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                3/50 (6%)                3/50 (6%)                3/50 (6%)       | 
|POLY-3 RATE (b)    |                  2/42.87                  3/43.05                  3/44.15                  3/42.45         | 
|POLY-3 PERCENT (g) |                  4.7%                     7.0%                     6.8%                     7.1%            | 
|TERMINAL (d)       |                  1/29 (3%)                2/28 (7%)                3/29 (10%)               3/26 (12%)      | 
|FIRST INCIDENCE    |                  709                      709                      729 (T)                  729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.385                  P=0.469                  P=0.495                  P=0.446         | 
|POLY 3             |                  P=0.432                  P=0.502                  P=0.513                  P=0.495         | 
|POLY 1.5           |                  P=0.438                  P=0.503                  P=0.510                  P=0.500         | 
|POLY 6             |                  P=0.417                  P=0.496                  P=0.512                  P=0.482         | 
|LOGISTIC REGRESSION|                  P=0.388                  P=0.484                  P=0.504                  P=0.448         | 
|COCH-ARM / FISHERS |                  P=0.438                  P=0.500                  P=0.500                  P=0.500         | 
|ORDER RESTRICTED   |                  P=0.514                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 29      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Nasolacrimal Duct                                                                                                          | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                0/50 (0%)                3/50 (6%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  0/42.79                  0/42.97                  3/44.29                  1/42.45         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     6.8%                     2.4%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/28 (0%)                1/29 (3%)                1/26 (4%)       | 
|FIRST INCIDENCE    |                  ---                      ---                      702                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.223                  (e)                      P=0.122                  P=0.478         | 
|POLY 3             |                  P=0.240                  (e)                      P=0.125                  P=0.498         | 
|POLY 1.5           |                  P=0.245                  (e)                      P=0.123                  P=0.500         | 
|POLY 6             |                  P=0.228                  (e)                      P=0.125                  P=0.493         | 
|LOGISTIC REGRESSION|                  P=0.228                  (e)                      P=0.124                  P=0.478         | 
|COCH-ARM / FISHERS |                  P=0.247                  (e)                      P=0.121                  P=0.500         | 
|ORDER RESTRICTED   |                  P=0.120                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Atrophy Focal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  31/49 (63%)              20/50 (40%)              23/50 (46%)              21/49 (43%)     | 
|POLY-3 RATE (b)    |                  31/45.31                 20/46.06                 23/46.25                 21/43.93        | 
|POLY-3 PERCENT (g) |                  68.4%                    43.4%                    49.7%                    47.8%           | 
|TERMINAL (d)       |                  21/29 (72%)              10/28 (36%)              15/29 (52%)              13/26 (50%)     | 
|FIRST INCIDENCE    |                  459                      520                      548                      485             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.174N                 P=0.057N                 P=0.101N                 P=0.122N        | 
|POLY 3             |                  P=0.078N                 P=0.011N*                P=0.048N*                P=0.033N*       | 
|POLY 1.5           |                  P=0.072N                 P=0.012N*                P=0.051N                 P=0.030N*       | 
|POLY 6             |                  P=0.094N                 P=0.010N*                P=0.048N*                P=0.041N*       | 
|LOGISTIC REGRESSION|                  P=0.074N                 P=0.017N*                P=0.052N                 P=0.035N*       | 
|COCH-ARM / FISHERS |                  P=0.074N                 P=0.017N*                P=0.064N                 P=0.034N*       | 
|ORDER RESTRICTED   |                  P=0.025N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 30      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Duct                                                                                                                   | 
|     Cyst Focal                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  16/49 (33%)              14/50 (28%)              17/50 (34%)              11/49 (22%)     | 
|POLY-3 RATE (b)    |                  16/43.24                 14/43.69                 17/45.47                 11/41.94        | 
|POLY-3 PERCENT (g) |                  37.0%                    32.0%                    37.4%                    26.2%           | 
|TERMINAL (d)       |                  11/29 (38%)              10/28 (36%)              11/29 (38%)              10/26 (39%)     | 
|FIRST INCIDENCE    |                  651                      620                      548                      705             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.280N                 P=0.470N                 P=0.507                  P=0.287N        | 
|POLY 3             |                  P=0.202N                 P=0.396N                 P=0.573                  P=0.199N        | 
|POLY 1.5           |                  P=0.192N                 P=0.389N                 P=0.559                  P=0.187N        | 
|POLY 6             |                  P=0.229N                 P=0.415N                 P=0.579                  P=0.228N        | 
|LOGISTIC REGRESSION|                  P=0.218N                 P=0.431N                 P=0.548                  P=0.252N        | 
|COCH-ARM / FISHERS |                  P=0.188N                 P=0.388N                 P=0.528                  P=0.183N        | 
|ORDER RESTRICTED   |                  P=0.230N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/49 (4%)                2/50 (4%)                0/50 (0%)                1/48 (2%)       | 
|POLY-3 RATE (b)    |                  2/42.35                  2/42.97                  0/44.15                  1/40.83         | 
|POLY-3 PERCENT (g) |                  4.7%                     4.7%                     0.0%                     2.5%            | 
|TERMINAL (d)       |                  1/29 (3%)                2/28 (7%)                0/29 (0%)                1/25 (4%)       | 
|FIRST INCIDENCE    |                  654                      729 (T)                  ---                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.330N                 P=0.689                  P=0.234N                 P=0.544N        | 
|POLY 3             |                  P=0.302N                 P=0.689N                 P=0.228N                 P=0.513N        | 
|POLY 1.5           |                  P=0.301N                 P=0.686N                 P=0.228N                 P=0.508N        | 
|POLY 6             |                  P=0.305N                 P=0.692                  P=0.230N                 P=0.525N        | 
|LOGISTIC REGRESSION|                  P=0.310N                 P=0.692N                 P=0.231N                 P=0.512N        | 
|COCH-ARM / FISHERS |                  P=0.302N                 P=0.684N                 P=0.242N                 P=0.508N        | 
|ORDER RESTRICTED   |                  P=0.274N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 31      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/49 (4%)                2/50 (4%)                2/50 (4%)                2/48 (4%)       | 
|POLY-3 RATE (b)    |                  2/42.25                  2/43.22                  2/44.70                  2/40.93         | 
|POLY-3 PERCENT (g) |                  4.7%                     4.6%                     4.5%                     4.9%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/28 (0%)                1/29 (3%)                1/25 (4%)       | 
|FIRST INCIDENCE    |                  702                      697                      561                      705             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.554                  P=0.658                  P=0.690                  P=0.640         | 
|POLY 3             |                  P=0.582                  P=0.686N                 P=0.674N                 P=0.683         | 
|POLY 1.5           |                  P=0.586                  P=0.684N                 P=0.677N                 P=0.687         | 
|POLY 6             |                  P=0.570                  P=0.692N                 P=0.675N                 P=0.672         | 
|LOGISTIC REGRESSION|                  P=0.587                  P=0.688N                 P=0.693                  P=0.677         | 
|COCH-ARM / FISHERS |                  P=0.586                  P=0.684N                 P=0.684N                 P=0.684         | 
|ORDER RESTRICTED   |                  P=0.721                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cytoplasmic Alteration Focal                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  7/49 (14%)               6/50 (12%)               1/50 (2%)                6/48 (13%)      | 
|POLY-3 RATE (b)    |                  7/43.51                  6/44.15                  1/44.15                  6/41.60         | 
|POLY-3 PERCENT (g) |                  16.1%                    13.6%                    2.3%                     14.4%           | 
|TERMINAL (d)       |                  3/29 (10%)               3/28 (11%)               1/29 (3%)                5/25 (20%)      | 
|FIRST INCIDENCE    |                  354                      520                      729 (T)                  448             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.449N                 P=0.512N                 P=0.038N*                P=0.588N        | 
|POLY 3             |                  P=0.399N                 P=0.489N                 P=0.028N*                P=0.535N        | 
|POLY 1.5           |                  P=0.393N                 P=0.485N                 P=0.028N*                P=0.522N        | 
|POLY 6             |                  P=0.413N                 P=0.501N                 P=0.029N*                P=0.565N        | 
|LOGISTIC REGRESSION|                  P=0.400N                 P=0.500N                 P=0.035N*                P=0.524N        | 
|COCH-ARM / FISHERS |                  P=0.391N                 P=0.484N                 P=0.028N*                P=0.516N        | 
|ORDER RESTRICTED   |                  P=0.198N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 32      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Degeneration Cystic Focal                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/49 (2%)                0/50 (0%)                0/50 (0%)                3/48 (6%)       | 
|POLY-3 RATE (b)    |                  1/42.82                  0/42.97                  0/44.15                  3/41.17         | 
|POLY-3 PERCENT (g) |                  2.3%                     0.0%                     0.0%                     7.3%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/28 (0%)                0/29 (0%)                2/25 (8%)       | 
|FIRST INCIDENCE    |                  459                      ---                      ---                      637             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.077                  P=0.496N                 P=0.496N                 P=0.281         | 
|POLY 3             |                  P=0.080                  P=0.499N                 P=0.494N                 P=0.291         | 
|POLY 1.5           |                  P=0.080                  P=0.497N                 P=0.494N                 P=0.296         | 
|POLY 6             |                  P=0.079                  P=0.504N                 P=0.496N                 P=0.280         | 
|LOGISTIC REGRESSION|                  P=0.073                  P=0.644N                 P=0.728N                 P=0.274         | 
|COCH-ARM / FISHERS |                  P=0.081                  P=0.495N                 P=0.495N                 P=0.301         | 
|ORDER RESTRICTED   |                  P=0.033 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hemorrhage Focal                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/49 (6%)                5/50 (10%)               1/50 (2%)                3/48 (6%)       | 
|POLY-3 RATE (b)    |                  3/42.63                  5/43.74                  1/44.15                  3/41.49         | 
|POLY-3 PERCENT (g) |                  7.0%                     11.4%                    2.3%                     7.2%            | 
|TERMINAL (d)       |                  2/29 (7%)                2/28 (7%)                1/29 (3%)                1/25 (4%)       | 
|FIRST INCIDENCE    |                  553                      654                      729 (T)                  633             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.468N                 P=0.361                  P=0.302N                 P=0.625         | 
|POLY 3             |                  P=0.434N                 P=0.370                  P=0.292N                 P=0.650         | 
|POLY 1.5           |                  P=0.431N                 P=0.371                  P=0.293N                 P=0.654         | 
|POLY 6             |                  P=0.443N                 P=0.364                  P=0.296N                 P=0.640         | 
|LOGISTIC REGRESSION|                  P=0.434N                 P=0.366                  P=0.299N                 P=0.650         | 
|COCH-ARM / FISHERS |                  P=0.433N                 P=0.369                  P=0.301N                 P=0.651         | 
|ORDER RESTRICTED   |                  P=0.328N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 33      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/49 (6%)                2/50 (4%)                2/50 (4%)                7/48 (15%)      | 
|POLY-3 RATE (b)    |                  3/43.38                  2/42.97                  2/44.15                  7/42.19         | 
|POLY-3 PERCENT (g) |                  6.9%                     4.7%                     4.5%                     16.6%           | 
|TERMINAL (d)       |                  1/29 (3%)                2/28 (7%)                2/29 (7%)                4/25 (16%)      | 
|FIRST INCIDENCE    |                  459                      729 (T)                  729 (T)                  485             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.043 *                P=0.506N                 P=0.494N                 P=0.140         | 
|POLY 3             |                  P=0.049 *                P=0.504N                 P=0.492N                 P=0.144         | 
|POLY 1.5           |                  P=0.050                  P=0.497N                 P=0.489N                 P=0.149         | 
|POLY 6             |                  P=0.047 *                P=0.518N                 P=0.500N                 P=0.135         | 
|LOGISTIC REGRESSION|                  P=0.047 *                P=0.516N                 P=0.552N                 P=0.128         | 
|COCH-ARM / FISHERS |                  P=0.050                  P=0.490N                 P=0.490N                 P=0.150         | 
|ORDER RESTRICTED   |                  P=0.038 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Rathke's Cleft                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/49 (4%)                2/50 (4%)                0/50 (0%)                0/48 (0%)       | 
|POLY-3 RATE (b)    |                  2/42.07                  2/42.97                  0/44.15                  0/40.83         | 
|POLY-3 PERCENT (g) |                  4.8%                     4.7%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  2/29 (7%)                2/28 (7%)                0/29 (0%)                0/25 (0%)       | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.097N                 P=0.684                  P=0.238N                 P=0.271N        | 
|POLY 3             |                  P=0.086N                 P=0.687N                 P=0.226N                 P=0.243N        | 
|POLY 1.5           |                  P=0.086N                 P=0.685N                 P=0.228N                 P=0.241N        | 
|POLY 6             |                  P=0.087N                 P=0.693N                 P=0.227N                 P=0.250N        | 
|LOGISTIC REGRESSION|                  P=0.097N                 P=0.684                  (e)                      (e)             | 
|COCH-ARM / FISHERS |                  P=0.087N                 P=0.684N                 P=0.242N                 P=0.253N        | 
|ORDER RESTRICTED   |                  P=0.121N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 34      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                0/50 (0%)                1/50 (2%)                2/49 (4%)       | 
|POLY-3 RATE (b)    |                  1/43.62                  0/42.97                  1/44.15                  2/42.07         | 
|POLY-3 PERCENT (g) |                  2.3%                     0.0%                     2.3%                     4.8%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/28 (0%)                1/29 (3%)                0/25 (0%)       | 
|FIRST INCIDENCE    |                  405                      ---                      729 (T)                  633             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.236                  P=0.496N                 P=0.758N                 P=0.496         | 
|POLY 3             |                  P=0.241                  P=0.503N                 P=0.758N                 P=0.487         | 
|POLY 1.5           |                  P=0.242                  P=0.501N                 P=0.758N                 P=0.491         | 
|POLY 6             |                  P=0.238                  P=0.507N                 P=0.760N                 P=0.480         | 
|LOGISTIC REGRESSION|                  P=0.200                  P=0.739N                 P=0.678                  P=0.394         | 
|COCH-ARM / FISHERS |                  P=0.242                  P=0.500N                 P=0.753N                 P=0.492         | 
|ORDER RESTRICTED   |                  P=0.213                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                1/50 (2%)                1/50 (2%)                2/49 (4%)       | 
|POLY-3 RATE (b)    |                  2/42.79                  1/42.97                  1/44.15                  2/42.35         | 
|POLY-3 PERCENT (g) |                  4.7%                     2.3%                     2.3%                     4.7%            | 
|TERMINAL (d)       |                  2/29 (7%)                1/28 (4%)                1/29 (3%)                0/25 (0%)       | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  729 (T)                  554             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.530                  P=0.512N                 P=0.500N                 P=0.676         | 
|POLY 3             |                  P=0.552                  P=0.499N                 P=0.489N                 P=0.691         | 
|POLY 1.5           |                  P=0.552                  P=0.498N                 P=0.492N                 P=0.691         | 
|POLY 6             |                  P=0.549                  P=0.503N                 P=0.489N                 P=0.685         | 
|LOGISTIC REGRESSION|                  P=0.548                  P=0.512N                 P=0.500N                 P=0.683         | 
|COCH-ARM / FISHERS |                  P=0.548                  P=0.500N                 P=0.500N                 P=0.684         | 
|ORDER RESTRICTED   |                  P=0.535                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 35      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  32/50 (64%)              30/50 (60%)              31/50 (62%)              37/49 (76%)     | 
|POLY-3 RATE (b)    |                  32/45.09                 30/45.87                 31/47.16                 37/46.05        | 
|POLY-3 PERCENT (g) |                  71.0%                    65.4%                    65.7%                    80.3%           | 
|TERMINAL (d)       |                  20/29 (69%)              18/28 (64%)              21/29 (72%)              20/25 (80%)     | 
|FIRST INCIDENCE    |                  553                      526                      526                      448             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.062                  P=0.508N                 P=0.493N                 P=0.098         | 
|POLY 3             |                  P=0.123                  P=0.361N                 P=0.373N                 P=0.201         | 
|POLY 1.5           |                  P=0.114                  P=0.374N                 P=0.411N                 P=0.185         | 
|POLY 6             |                  P=0.125                  P=0.367N                 P=0.360N                 P=0.203         | 
|LOGISTIC REGRESSION|                  P=0.089                  P=0.391N                 P=0.412N                 P=0.142         | 
|COCH-ARM / FISHERS |                  P=0.095                  P=0.418N                 P=0.500N                 P=0.152         | 
|ORDER RESTRICTED   |                  P=0.121                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  29/50 (58%)              33/50 (66%)              35/50 (70%)              38/50 (76%)     | 
|POLY-3 RATE (b)    |                  29/46.69                 33/47.27                 35/48.80                 38/48.94        | 
|POLY-3 PERCENT (g) |                  62.1%                    69.8%                    71.7%                    77.6%           | 
|TERMINAL (d)       |                  16/29 (55%)              20/28 (71%)              20/29 (69%)              17/26 (65%)     | 
|FIRST INCIDENCE    |                  405                      520                      430                      448             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.044 *                P=0.274                  P=0.234                  P=0.058         | 
|POLY 3             |                  P=0.062                  P=0.281                  P=0.213                  P=0.070         | 
|POLY 1.5           |                  P=0.052                  P=0.280                  P=0.192                  P=0.060         | 
|POLY 6             |                  P=0.070                  P=0.270                  P=0.223                  P=0.078         | 
|LOGISTIC REGRESSION|                  P=0.035 *                P=0.275                  P=0.148                  P=0.044 *       | 
|COCH-ARM / FISHERS |                  P=0.035 *                P=0.268                  P=0.149                  P=0.044 *       | 
|ORDER RESTRICTED   |                  P=0.066                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 36      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Mineralization Focal                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                0/50 (0%)                0/50 (0%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  0/42.79                  0/42.97                  0/44.15                  2/42.45         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     0.0%                     4.7%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/28 (0%)                0/29 (0%)                2/26 (8%)       | 
|FIRST INCIDENCE    |                  ---                      ---                      ---                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.039 *                (e)                      (e)                      P=0.214         | 
|POLY 3             |                  P=0.045 *                (e)                      (e)                      P=0.235         | 
|POLY 1.5           |                  P=0.045 *                (e)                      (e)                      P=0.237         | 
|POLY 6             |                  P=0.044 *                (e)                      (e)                      P=0.229         | 
|LOGISTIC REGRESSION|                  (e)                      (e)                      (e)                      P=0.214         | 
|COCH-ARM / FISHERS |                  P=0.046 *                (e)                      (e)                      P=0.247         | 
|ORDER RESTRICTED   |                  P=0.029 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate: Epithelium                                                                                                             | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  25/50 (50%)              21/50 (42%)              24/50 (48%)              23/50 (46%)     | 
|POLY-3 RATE (b)    |                  25/46.09                 21/45.12                 24/46.23                 23/45.43        | 
|POLY-3 PERCENT (g) |                  54.2%                    46.6%                    51.9%                    50.6%           | 
|TERMINAL (d)       |                  13/29 (45%)              14/28 (50%)              17/29 (59%)              13/26 (50%)     | 
|FIRST INCIDENCE    |                  526                      561                      526                      554             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.452                  P=0.332N                 P=0.486N                 P=0.560         | 
|POLY 3             |                  P=0.483N                 P=0.297N                 P=0.494N                 P=0.445N        | 
|POLY 1.5           |                  P=0.468N                 P=0.278N                 P=0.483N                 P=0.423N        | 
|POLY 6             |                  P=0.522N                 P=0.341N                 P=0.537N                 P=0.497N        | 
|LOGISTIC REGRESSION|                  P=0.468N                 P=0.263N                 P=0.464N                 P=0.416N        | 
|COCH-ARM / FISHERS |                  P=0.471N                 P=0.274N                 P=0.500N                 P=0.421N        | 
|ORDER RESTRICTED   |                  P=0.520N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 37      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Cyst Epithelial Inclusion                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                0/50 (0%)                0/50 (0%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  0/42.79                  0/42.97                  0/44.15                  2/43.21         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     0.0%                     4.6%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/28 (0%)                0/29 (0%)                1/26 (4%)       | 
|FIRST INCIDENCE    |                  ---                      ---                      ---                      448             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.045 *                (e)                      (e)                      P=0.232         | 
|POLY 3             |                  P=0.046 *                (e)                      (e)                      P=0.239         | 
|POLY 1.5           |                  P=0.046 *                (e)                      (e)                      P=0.240         | 
|POLY 6             |                  P=0.045 *                (e)                      (e)                      P=0.234         | 
|LOGISTIC REGRESSION|                  P=0.033 *                (e)                      (e)                      P=0.185         | 
|COCH-ARM / FISHERS |                  P=0.046 *                (e)                      (e)                      P=0.247         | 
|ORDER RESTRICTED   |                  P=0.030 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Angiectasis Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/48 (2%)                2/49 (4%)                0/49 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  1/41.90                  2/42.22                  0/43.45                  0/42.45         | 
|POLY-3 PERCENT (g) |                  2.4%                     4.7%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  1/29 (3%)                1/28 (4%)                0/29 (0%)                0/26 (0%)       | 
|FIRST INCIDENCE    |                  729 (T)                  697                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.205N                 P=0.485                  P=0.500N                 P=0.522N        | 
|POLY 3             |                  P=0.184N                 P=0.503                  P=0.493N                 P=0.497N        | 
|POLY 1.5           |                  P=0.183N                 P=0.506                  P=0.493N                 P=0.494N        | 
|POLY 6             |                  P=0.188N                 P=0.497                  P=0.494N                 P=0.504N        | 
|LOGISTIC REGRESSION|                  P=0.192N                 P=0.490                  (e)                      (e)             | 
|COCH-ARM / FISHERS |                  P=0.182N                 P=0.508                  P=0.495N                 P=0.490N        | 
|ORDER RESTRICTED   |                  P=0.166N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 38      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Fibrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  4/48 (8%)                3/49 (6%)                1/49 (2%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  4/41.98                  3/42.22                  1/43.57                  1/42.45         | 
|POLY-3 PERCENT (g) |                  9.5%                     7.1%                     2.3%                     2.4%            | 
|TERMINAL (d)       |                  3/29 (10%)               2/28 (7%)                0/29 (0%)                1/26 (4%)       | 
|FIRST INCIDENCE    |                  709                      697                      697                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.112N                 P=0.527N                 P=0.187N                 P=0.217N        | 
|POLY 3             |                  P=0.087N                 P=0.497N                 P=0.167N                 P=0.174N        | 
|POLY 1.5           |                  P=0.086N                 P=0.492N                 P=0.168N                 P=0.170N        | 
|POLY 6             |                  P=0.090N                 P=0.507N                 P=0.167N                 P=0.185N        | 
|LOGISTIC REGRESSION|                  P=0.098N                 P=0.524N                 P=0.170N                 P=0.210N        | 
|COCH-ARM / FISHERS |                  P=0.086N                 P=0.488N                 P=0.175N                 P=0.168N        | 
|ORDER RESTRICTED   |                  P=0.106N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  6/48 (13%)               7/49 (14%)               5/49 (10%)               11/50 (22%)     | 
|POLY-3 RATE (b)    |                  6/43.95                  7/44.11                  5/44.85                  11/44.60        | 
|POLY-3 PERCENT (g) |                  13.7%                    15.9%                    11.2%                    24.7%           | 
|TERMINAL (d)       |                  2/29 (7%)                2/28 (7%)                0/29 (0%)                5/26 (19%)      | 
|FIRST INCIDENCE    |                  354                      526                      526                      485             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.099                  P=0.495                  P=0.490N                 P=0.132         | 
|POLY 3             |                  P=0.109                  P=0.503                  P=0.486N                 P=0.147         | 
|POLY 1.5           |                  P=0.114                  P=0.507                  P=0.486N                 P=0.155         | 
|POLY 6             |                  P=0.101                  P=0.498                  P=0.485N                 P=0.134         | 
|LOGISTIC REGRESSION|                  P=0.111                  P=0.510                  P=0.581N                 P=0.160         | 
|COCH-ARM / FISHERS |                  P=0.120                  P=0.516                  P=0.485N                 P=0.165         | 
|ORDER RESTRICTED   |                  P=0.119                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 39      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/48 (0%)                0/49 (0%)                0/49 (0%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  0/41.90                  0/42.10                  0/43.45                  2/42.83         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     0.0%                     4.7%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/28 (0%)                0/29 (0%)                1/26 (4%)       | 
|FIRST INCIDENCE    |                  ---                      ---                      ---                      619             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.044 *                (e)                      (e)                      P=0.230         | 
|POLY 3             |                  P=0.047 *                (e)                      (e)                      P=0.242         | 
|POLY 1.5           |                  P=0.048 *                (e)                      (e)                      P=0.245         | 
|POLY 6             |                  P=0.046 *                (e)                      (e)                      P=0.235         | 
|LOGISTIC REGRESSION|                  P=0.049 *                (e)                      (e)                      P=0.247         | 
|COCH-ARM / FISHERS |                  P=0.049 *                (e)                      (e)                      P=0.258         | 
|ORDER RESTRICTED   |                  P=0.031 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/48 (4%)                1/49 (2%)                1/49 (2%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  2/42.54                  1/42.18                  1/43.45                  0/42.45         | 
|POLY-3 PERCENT (g) |                  4.7%                     2.4%                     2.3%                     0.0%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/28 (0%)                1/29 (3%)                0/26 (0%)       | 
|FIRST INCIDENCE    |                  553                      709                      729 (T)                  ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.167N                 P=0.526N                 P=0.502N                 P=0.252N        | 
|POLY 3             |                  P=0.151N                 P=0.503N                 P=0.493N                 P=0.237N        | 
|POLY 1.5           |                  P=0.149N                 P=0.498N                 P=0.491N                 P=0.232N        | 
|POLY 6             |                  P=0.155N                 P=0.512N                 P=0.497N                 P=0.247N        | 
|LOGISTIC REGRESSION|                  P=0.147N                 P=0.494N                 P=0.511N                 P=0.234N        | 
|COCH-ARM / FISHERS |                  P=0.147N                 P=0.492N                 P=0.492N                 P=0.237N        | 
|ORDER RESTRICTED   |                  P=0.118N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 40      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                2/50 (4%)                3/50 (6%)                4/50 (8%)       | 
|POLY-3 RATE (b)    |                  2/42.98                  2/43.61                  3/44.63                  4/44.24         | 
|POLY-3 PERCENT (g) |                  4.7%                     4.6%                     6.7%                     9.0%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/28 (0%)                0/29 (0%)                0/26 (0%)       | 
|FIRST INCIDENCE    |                  702                      620                      633                      448             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.201                  P=0.674                  P=0.502                  P=0.314         | 
|POLY 3             |                  P=0.227                  P=0.689N                 P=0.517                  P=0.350         | 
|POLY 1.5           |                  P=0.225                  P=0.689N                 P=0.512                  P=0.348         | 
|POLY 6             |                  P=0.225                  P=0.692N                 P=0.519                  P=0.346         | 
|LOGISTIC REGRESSION|                  P=0.193                  P=0.692                  P=0.505                  P=0.295         | 
|COCH-ARM / FISHERS |                  P=0.216                  P=0.691N                 P=0.500                  P=0.339         | 
|ORDER RESTRICTED   |                  P=0.315                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation Diffuse                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                0/50 (0%)                2/50 (4%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  0/42.79                  0/42.97                  2/44.79                  0/42.45         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     4.5%                     0.0%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/28 (0%)                0/29 (0%)                0/26 (0%)       | 
|FIRST INCIDENCE    |                  ---                      ---                      633                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.587                  (e)                      P=0.250                  (e)             | 
|POLY 3             |                  P=0.587                  (e)                      P=0.247                  (e)             | 
|POLY 1.5           |                  P=0.593                  (e)                      P=0.244                  (e)             | 
|POLY 6             |                  P=0.572                  (e)                      P=0.250                  (e)             | 
|LOGISTIC REGRESSION|                  P=0.579                  (e)                      P=0.204                  (e)             | 
|COCH-ARM / FISHERS |                  P=0.595                  (e)                      P=0.247                  (e)             | 
|ORDER RESTRICTED   |                  P=0.256                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 41      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation Focal                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                2/50 (4%)                2/50 (4%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  1/42.87                  2/43.13                  2/44.52                  1/42.53         | 
|POLY-3 PERCENT (g) |                  2.3%                     4.6%                     4.5%                     2.4%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/28 (0%)                0/29 (0%)                0/26 (0%)       | 
|FIRST INCIDENCE    |                  709                      709                      665                      709             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.599N                 P=0.457                  P=0.502                  P=0.727         | 
|POLY 3             |                  P=0.557N                 P=0.502                  P=0.513                  P=0.759         | 
|POLY 1.5           |                  P=0.554N                 P=0.503                  P=0.509                  P=0.760N        | 
|POLY 6             |                  P=0.567N                 P=0.498                  P=0.515                  P=0.753         | 
|LOGISTIC REGRESSION|                  P=0.557N                 P=0.499                  P=0.502                  P=0.757         | 
|COCH-ARM / FISHERS |                  P=0.556N                 P=0.500                  P=0.500                  P=0.753N        | 
|ORDER RESTRICTED   |                  P=0.554                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                4/50 (8%)                4/50 (8%)                4/50 (8%)       | 
|POLY-3 RATE (b)    |                  1/42.87                  4/44.32                  4/45.09                  4/44.26         | 
|POLY-3 PERCENT (g) |                  2.3%                     9.0%                     8.9%                     9.0%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/28 (0%)                0/29 (0%)                0/26 (0%)       | 
|FIRST INCIDENCE    |                  709                      520                      633                      448             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.195                  P=0.177                  P=0.191                  P=0.178         | 
|POLY 3             |                  P=0.219                  P=0.188                  P=0.194                  P=0.188         | 
|POLY 1.5           |                  P=0.217                  P=0.186                  P=0.189                  P=0.186         | 
|POLY 6             |                  P=0.216                  P=0.189                  P=0.198                  P=0.186         | 
|LOGISTIC REGRESSION|                  P=0.169                  P=0.162                  P=0.168                  P=0.135         | 
|COCH-ARM / FISHERS |                  P=0.205                  P=0.181                  P=0.181                  P=0.181         | 
|ORDER RESTRICTED   |                  P=0.182                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 42      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                5/50 (10%)               4/50 (8%)                6/50 (12%)      | 
|POLY-3 RATE (b)    |                  2/43.62                  5/44.10                  4/44.90                  6/43.89         | 
|POLY-3 PERCENT (g) |                  4.6%                     11.3%                    8.9%                     13.7%           | 
|TERMINAL (d)       |                  0/29 (0%)                0/28 (0%)                0/29 (0%)                1/26 (4%)       | 
|FIRST INCIDENCE    |                  479                      520                      642                      633             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.125                  P=0.202                  P=0.350                  P=0.129         | 
|POLY 3             |                  P=0.143                  P=0.220                  P=0.350                  P=0.134         | 
|POLY 1.5           |                  P=0.145                  P=0.220                  P=0.347                  P=0.135         | 
|POLY 6             |                  P=0.140                  P=0.217                  P=0.352                  P=0.130         | 
|LOGISTIC REGRESSION|                  P=0.130                  P=0.193                  P=0.287                  P=0.118         | 
|COCH-ARM / FISHERS |                  P=0.142                  P=0.218                  P=0.339                  P=0.134         | 
|ORDER RESTRICTED   |                  P=0.115                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/49 (4%)                4/50 (8%)                1/50 (2%)                4/50 (8%)       | 
|POLY-3 RATE (b)    |                  2/42.20                  4/44.87                  1/44.30                  4/43.57         | 
|POLY-3 PERCENT (g) |                  4.7%                     8.9%                     2.3%                     9.2%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/28 (0%)                0/29 (0%)                1/26 (4%)       | 
|FIRST INCIDENCE    |                  702                      405                      691                      616             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.342                  P=0.331                  P=0.500N                 P=0.321         | 
|POLY 3             |                  P=0.368                  P=0.366                  P=0.483N                 P=0.352         | 
|POLY 1.5           |                  P=0.369                  P=0.361                  P=0.485N                 P=0.352         | 
|POLY 6             |                  P=0.361                  P=0.365                  P=0.485N                 P=0.344         | 
|LOGISTIC REGRESSION|                  P=0.323                  P=0.295                  P=0.485N                 P=0.342         | 
|COCH-ARM / FISHERS |                  P=0.364                  P=0.349                  P=0.492N                 P=0.349         | 
|ORDER RESTRICTED   |                  P=0.318                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 43      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular: Epithelium                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/49 (0%)                0/50 (0%)                0/50 (0%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  0/42.07                  0/42.97                  0/44.15                  2/43.92         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     0.0%                     4.6%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/28 (0%)                0/29 (0%)                0/26 (0%)       | 
|FIRST INCIDENCE    |                  ---                      ---                      ---                      448             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.049 *                (e)                      (e)                      P=0.251         | 
|POLY 3             |                  P=0.047 *                (e)                      (e)                      P=0.247         | 
|POLY 1.5           |                  P=0.047 *                (e)                      (e)                      P=0.247         | 
|POLY 6             |                  P=0.047 *                (e)                      (e)                      P=0.242         | 
|LOGISTIC REGRESSION|                  P=0.006 **               (e)                      (e)                      P=0.061         | 
|COCH-ARM / FISHERS |                  P=0.047 *                (e)                      (e)                      P=0.253         | 
|ORDER RESTRICTED   |                  P=0.033 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  6/50 (12%)               8/50 (16%)               9/50 (18%)               9/50 (18%)      | 
|POLY-3 RATE (b)    |                  6/43.77                  8/44.21                  9/46.05                  9/43.27         | 
|POLY-3 PERCENT (g) |                  13.7%                    18.1%                    19.5%                    20.8%           | 
|TERMINAL (d)       |                  1/29 (3%)                4/28 (14%)               3/29 (10%)               6/26 (23%)      | 
|FIRST INCIDENCE    |                  620                      561                      526                      633             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.220                  P=0.370                  P=0.314                  P=0.239         | 
|POLY 3             |                  P=0.247                  P=0.393                  P=0.324                  P=0.277         | 
|POLY 1.5           |                  P=0.256                  P=0.395                  P=0.313                  P=0.286         | 
|POLY 6             |                  P=0.225                  P=0.383                  P=0.328                  P=0.254         | 
|LOGISTIC REGRESSION|                  P=0.257                  P=0.387                  P=0.263                  P=0.285         | 
|COCH-ARM / FISHERS |                  P=0.257                  P=0.387                  P=0.288                  P=0.288         | 
|ORDER RESTRICTED   |                  P=0.312                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 44      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Interstitial Cell                                                                                                        | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                2/50 (4%)                3/50 (6%)                3/50 (6%)       | 
|POLY-3 RATE (b)    |                  3/44.81                  2/43.53                  3/44.72                  3/43.64         | 
|POLY-3 PERCENT (g) |                  6.7%                     4.6%                     6.7%                     6.9%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/28 (0%)                0/29 (0%)                1/26 (4%)       | 
|FIRST INCIDENCE    |                  354                      620                      665                      448             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.506                  P=0.496N                 P=0.648N                 P=0.658         | 
|POLY 3             |                  P=0.512                  P=0.513N                 P=0.662                  P=0.650         | 
|POLY 1.5           |                  P=0.518                  P=0.507N                 P=0.662N                 P=0.657         | 
|POLY 6             |                  P=0.500                  P=0.522N                 P=0.660                  P=0.637         | 
|LOGISTIC REGRESSION|                  P=0.423                  P=0.627N                 P=0.498                  P=0.511         | 
|COCH-ARM / FISHERS |                  P=0.521                  P=0.500N                 P=0.661N                 P=0.661N        | 
|ORDER RESTRICTED   |                  P=0.632                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  44/46 (96%)              46/48 (96%)              40/44 (91%)              41/42 (98%)     | 
|POLY-3 RATE (b)    |                  44/46.00                 46/47.36                 40/42.32                 41/41.92        | 
|POLY-3 PERCENT (g) |                  95.7%                    97.1%                    94.5%                    97.8%           | 
|TERMINAL (d)       |                  27/29 (93%)              28/28 (100%)             28/29 (97%)              26/26 (100%)    | 
|FIRST INCIDENCE    |                  354                      405                      526                      448             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.482N                 P=0.359                  P=0.286N                 P=0.517         | 
|POLY 3             |                  P=0.446                  P=0.572                  P=0.605N                 P=0.513         | 
|POLY 1.5           |                  P=0.459                  P=0.626                  P=0.479N                 P=0.522         | 
|POLY 6             |                  P=0.430                  P=0.474                  P=0.685                  P=0.495         | 
|LOGISTIC REGRESSION|                  P=0.531                  P=0.680                  P=0.243N                 P=0.533         | 
|COCH-ARM / FISHERS |                  P=0.481                  P=0.675                  P=0.317N                 P=0.534         | 
|ORDER RESTRICTED   |                  P=0.446                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 45      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicle                                                                                                          | 
|     Degeneration Cystic Focal                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/46 (0%)                2/48 (4%)                0/44 (0%)                0/42 (0%)       | 
|POLY-3 RATE (b)    |                  0/40.05                  2/41.28                  0/39.67                  0/37.14         | 
|POLY-3 PERCENT (g) |                  0.0%                     4.8%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  0/29 (0%)                2/28 (7%)                0/29 (0%)                0/26 (0%)       | 
|FIRST INCIDENCE    |                  ---                      729 (T)                  ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.424N                 P=0.230                  (e)                      (e)             | 
|POLY 3             |                  P=0.423N                 P=0.244                  (e)                      (e)             | 
|POLY 1.5           |                  P=0.423N                 P=0.246                  (e)                      (e)             | 
|POLY 6             |                  P=0.425N                 P=0.239                  (e)                      (e)             | 
|LOGISTIC REGRESSION|                  (e)                      P=0.230                  (e)                      (e)             | 
|COCH-ARM / FISHERS |                  P=0.427N                 P=0.258                  (e)                      (e)             | 
|ORDER RESTRICTED   |                  P=0.268N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/46 (0%)                0/48 (0%)                0/44 (0%)                2/42 (5%)       | 
|POLY-3 RATE (b)    |                  0/40.05                  0/41.28                  0/39.67                  2/37.14         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     0.0%                     5.4%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/28 (0%)                0/29 (0%)                2/26 (8%)       | 
|FIRST INCIDENCE    |                  ---                      ---                      ---                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.039 *                (e)                      (e)                      P=0.214         | 
|POLY 3             |                  P=0.038 *                (e)                      (e)                      P=0.220         | 
|POLY 1.5           |                  P=0.038 *                (e)                      (e)                      P=0.219         | 
|POLY 6             |                  P=0.039 *                (e)                      (e)                      P=0.219         | 
|LOGISTIC REGRESSION|                  (e)                      (e)                      (e)                      P=0.214         | 
|COCH-ARM / FISHERS |                  P=0.039 *                (e)                      (e)                      P=0.225         | 
|ORDER RESTRICTED   |                  P=0.024 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96018 TEST: 03                                            Page 46      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hyperplasia Cystic Focal                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  5/46 (11%)               4/48 (8%)                4/44 (9%)                3/42 (7%)       | 
|POLY-3 RATE (b)    |                  5/40.24                  4/41.28                  4/40.01                  3/38.02         | 
|POLY-3 PERCENT (g) |                  12.4%                    9.7%                     10.0%                    7.9%            | 
|TERMINAL (d)       |                  4/29 (14%)               4/28 (14%)               3/29 (10%)               1/26 (4%)       | 
|FIRST INCIDENCE    |                  680                      729 (T)                  633                      554             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.341N                 P=0.524N                 P=0.497N                 P=0.403N        | 
|POLY 3             |                  P=0.333N                 P=0.484N                 P=0.504N                 P=0.387N        | 
|POLY 1.5           |                  P=0.343N                 P=0.477N                 P=0.512N                 P=0.393N        | 
|POLY 6             |                  P=0.324N                 P=0.498N                 P=0.497N                 P=0.383N        | 
|LOGISTIC REGRESSION|                  P=0.347N                 P=0.516N                 P=0.505N                 P=0.407N        | 
|COCH-ARM / FISHERS |                  P=0.358N                 P=0.473N                 P=0.529N                 P=0.409N        | 
|ORDER RESTRICTED   |                  P=0.404N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).