TDMS Study 96018-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) DATE: 04/15/03
EXPERIMENT: 96018 TEST: 03 TIME: 15:32:55
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-85420 ROUTE: DOSED WATER NTP C#: C96018
PATHOLOGIST: FARNELL, DANIEL R. CAS: 75-27-4
------------------------------------------------------------------------------------------------------------------------------------
FINAL#1/RATS
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) DATE: 04/15/03
EXPERIMENT: 96018 TEST: 03 TIME: 15:32:55
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-85420 ROUTE: DOSED WATER NTP C#: C96018
PATHOLOGIST: FARNELL, DANIEL R. CAS: 75-27-4
WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 354 405 459 479 526 553 610 620 620 651 |
| 654 655 680 683 702 709 709 709 718 722 |
| 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 175 MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 1 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 405 520 526 556 561 620 624 651 654 660 |
| 667 667 681 683 695 697 697 697 709 709 |
| 709 |
| CENSORED DEATHS |
| 498 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 350 MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 430 526 548 561 605 628 633 642 649 665 |
| 667 669 669 691 697 702 703 709 721 722 |
| 727 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 700 MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 24 CENSORED DEATHS 0 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 448 485 486 554 605 616 619 633 633 636 |
| 637 642 642 644 654 672 686 693 695 705 |
| 709 709 709 722 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/L | 100.0 100.0 100.0 98.0 96.0 92.0 90.0 88.0 76.0 58.0 |
| | |
| | |
|175 MG/L | 100.0 100.0 100.0 100.0 98.0 98.0 93.9 89.8 79.6 57.2 |
| | |
| | |
|350 MG/L | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 90.0 80.0 58.0 |
| | |
| | |
|700 MG/L | 100.0 100.0 100.0 100.0 100.0 96.0 94.0 90.0 70.0 52.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 58.0% 57.2% 58.0% 52.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.547 P=1.000 P=1.000N P=0.630 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 616.2 637.5 645.9 634.8 |
|NATURAL DEATHS (C) | (24.3) (17.5) (16.5) (15.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 681.6 686.0 694.1 683.8 |
|(STANDARD ERROR) | (12.8) (10.4) ( 9.0) ( 9.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)
KAPLAN-MEIER SURVIVAL CURVES
0 MG/L = 1
175 MG/L = 2
350 MG/L = 3
700 MG/L = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 1 2 3 4
|
| 1 1 3 4 4 23
| 1 1 22 3
95 +
| 1 14 2 323
| 1 1 22 3
|
90 + 1 1 2 3423
|
| 1 1223
| 112332
P 85 +
E | 322
R | 1 1 3
C | 2 2
E 80 + 11 22
N |
T | 44
| 1 1
S 75 + 2 2
U | 3 3
R | 4 4 1331
V | 2 2
I 70 + 4 4 311
V |
A | 4 4
L | 44 33
65 +
| 42 11
| 44 11
|
60 + 44
|
| 2 1 1
|
55 +
| 4 4
| 4 4
|
50 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 29 obs hidden.