National Toxicology Program

National Toxicology Program
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TDMS Study 96018-03 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Southern Research Inst               WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                 DATE: 04/15/03       
EXPERIMENT: 96018 TEST: 03                                                                                     TIME: 15:32:55       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: C96018       
PATHOLOGIST: FARNELL, DANIEL R.                                                                                CAS: 75-27-4         
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                                                            FINAL#1/RATS                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Southern Research Inst               WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                 DATE: 04/15/03       
EXPERIMENT: 96018 TEST: 03                                                                                     TIME: 15:32:55       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: C96018       
PATHOLOGIST: FARNELL, DANIEL R.                                                                                CAS: 75-27-4         
                                                                                                                                   
               WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                                                                 
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE RATS                                                                                      
                       FIRST TERMINAL SACRIFICE AT 729 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                                DOSE = 0 MG/L                                   |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 21     CENSORED DEATHS 0    TERMINAL 29        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      354   405   459   479   526   553   610   620   620   651                 |                                                 
 |      654   655   680   683   702   709   709   709   718   722                 |                                                 
 |      722                                                                       |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 175 MG/L                                 |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 21     CENSORED DEATHS 1    TERMINAL 28        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      405   520   526   556   561   620   624   651   654   660                 |                                                 
 |      667   667   681   683   695   697   697   697   709   709                 |                                                 
 |      709                                                                       |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      498                                                                       |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 350 MG/L                                 |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 21     CENSORED DEATHS 0    TERMINAL 29        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      430   526   548   561   605   628   633   642   649   665                 |                                                 
 |      667   669   669   691   697   702   703   709   721   722                 |                                                 
 |      727                                                                       |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
               WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                                                                 
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE RATS                                                                                      
                       FIRST TERMINAL SACRIFICE AT 729 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                                DOSE = 700 MG/L                                 |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 24     CENSORED DEATHS 0    TERMINAL 26        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      448   485   486   554   605   616   619   633   633   636                 |                                                 
 |      637   642   642   644   654   672   686   693   695   705                 |                                                 
 |      709   709   709   722                                                     |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
               WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                                                                 
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE RATS                                                                                      
                       FIRST TERMINAL SACRIFICE AT 729 DAYS                                                                         
 ==================================================================================                                                 
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |    DOSE                               TIME (DAYS)                              |                                                 
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |           |                                                                    |                                                 
 |0 MG/L     |   100.0 100.0 100.0  98.0  96.0  92.0  90.0  88.0  76.0  58.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |175 MG/L   |   100.0 100.0 100.0 100.0  98.0  98.0  93.9  89.8  79.6  57.2      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |350 MG/L   |   100.0 100.0 100.0 100.0 100.0  98.0  96.0  90.0  80.0  58.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |700 MG/L   |   100.0 100.0 100.0 100.0 100.0  96.0  94.0  90.0  70.0  52.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 ==================================================================================                                                 
 ==================================================================================                                                 
 |                           SURVIVAL SUMMARY STATISTICS                          |                                                 
 |                                                                                |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                                  DOSE                          |                                                 
 |                                                                                |                                                 
 |                                0 MG/L       175 MG/L     350 MG/L     700 MG/L |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |SURVIVAL AT END OF STUDY|       58.0%        57.2%        58.0%        52.0%    |                                                 
 |(KAPLAN-MEIER)          |                                                       |                                                 
 |                        |                                                       |                                                 
 |SIGNIFICANCE (B)        |       P=0.547      P=1.000      P=1.000N     P=0.630  |                                                 
 |(LIFE TABLE)            |                                                       |                                                 
 |                        |                                                       |                                                 
 |MEAN DAY OF             |       616.2        637.5        645.9        634.8    |                                                 
 |NATURAL DEATHS (C)      |       (24.3)       (17.5)       (16.5)       (15.2)   |                                                 
 |(STANDARD ERROR)        |                                                       |                                                 
 |                        |                                                       |                                                 
 |MEAN LIFE SPAN (D)      |       681.6        686.0        694.1        683.8    |                                                 
 |(STANDARD ERROR)        |       (12.8)       (10.4)       ( 9.0)       ( 9.9)   |                                                 
 |                        |                                                       |                                                 
 ==================================================================================                                                 
                                                                                                                                    
       (A)  FIRST TERMINAL SACRIFICE                                                                                                
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.                                                                
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS                                                                    
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".                                                                      
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE                                                               
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)                                                           
                                                                                                                                   
                                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                                        
                                                    KAPLAN-MEIER SURVIVAL CURVES                                                    
                                                        0 MG/L           = 1                                                        
                                                        175 MG/L         = 2                                                        
                                                        350 MG/L         = 3                                                        
                                                        700 MG/L         = 4                                                        
                                                                                                                                    
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
                                                                                                                                    
                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.                                           
                                                                                                                                    
      |                                                                                                                             
  100 + 1                                                       1       2   3 4                                                     
      |                                                                                                                             
      |                                                         1       1   3 4      4     23                                       
      |                                                                 1        1         22  3                                    
   95 +                                                                                                                             
      |                                                                          1  14      2  323                                  
      |                                                                             1       1   22      3                           
      |                                                                                                                             
   90 +                                                                                     1  1 2      3423                        
      |                                                                                                                             
      |                                                                                        1         1223                       
      |                                                                                                  112332                     
P  85 +                                                                                                                             
E     |                                                                                                      322                    
R     |                                                                                                   1   1  3                  
C     |                                                                                                        2 2                  
E  80 +                                                                                                       11 22                 
N     |                                                                                                                             
T     |                                                                                                     44                      
      |                                                                                                        1    1               
S  75 +                                                                                                           2 2               
U     |                                                                                                           3  3              
R     |                                                                                                      4 4    1331            
V     |                                                                                                             2 2             
I  70 +                                                                                                        4  4   311           
V     |                                                                                                                             
A     |                                                                                                           4 4               
L     |                                                                                                             44 33           
   65 +                                                                                                                             
      |                                                                                                              42 11          
      |                                                                                                               44 11         
      |                                                                                                                             
   60 +                                                                                                                44           
      |                                                                                                                             
      |                                                                                                                 2 1 1       
      |                                                                                                                             
   55 +                                                                                                                             
      |                                                                                                                 4 4         
      |                                                                                                                   4 4       
      |                                                                                                                             
   50 +                                                                                                                             
      |                                                                                                                             
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110 
                                                                                                                                    
                                                                   WEEK                                                             
                                                                                                                                    
NOTE: 29 obs hidden.                                                                                                                
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