National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/21275

TDMS Study 96003-03 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: BIORELIANCE                                              ALLYL BROMIDE                                    DATE: 11/14/03       
EXPERIMENT: 96003 TEST: 03                                                                                     TIME: 14:44:36       
TEST TYPE:  26-39 WEEKS                         CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-25408                              ROUTE: GAVAGE                                                  NTP C#: 96003C       
PATHOLOGIST: LANNING, LYNDA                                                                                    CAS: 106-95-6        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    VEHICLE CONTROL                                                               
                                       INCLUDE 002    0.5     MG/KG                                                                 
                                       INCLUDE 003    1 MG/KG                                                                       
                                       INCLUDE 004    2 MG/KG                                                                       
                                       INCLUDE 005    4 MG/KG                                                                       
                                       INCLUDE 006    8 MG/KG                                                                       
                                       INCLUDE 008    VEHICLE CONTROL                                                               
                                       INCLUDE 009    0.5     MG/KG                                                                 
                                       INCLUDE 010    1 MG/KG                                                                       
                                       INCLUDE 011    2 MG/KG                                                                       
                                       INCLUDE 012    4 MG/KG                                                                       
                                       INCLUDE 013    8 MG/KG                                                                       
                                                                                                                                   
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: BIORELIANCE                                              ALLYL BROMIDE                                    DATE: 11/14/03       
EXPERIMENT: 96003 TEST: 03                                                                                     TIME: 14:44:36       
TEST TYPE:  26-39 WEEKS                         CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-25408                              ROUTE: GAVAGE                                                  NTP C#: 96003C       
PATHOLOGIST: LANNING, LYNDA                                                                                    CAS: 106-95-6        
                                                                                                                                   
                                   ALLYL BROMIDE                                                                                    
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE MICE                                                                                      
                       FIRST TERMINAL SACRIFICE AT 275 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                          DOSE = VEHICLE CONTROL                                |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 15     UNCENSORED DEATHS 3      CENSORED DEATHS 0    TERMINAL 12        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      173   241   245                                                           |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                          DOSE = 0.5     MG/KG                                  |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 15     UNCENSORED DEATHS 5      CENSORED DEATHS 1    TERMINAL 9         |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      163   169   186   206   219                                               |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      8                                                                         |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 1 MG/KG                                  |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 15     UNCENSORED DEATHS 6      CENSORED DEATHS 0    TERMINAL 9         |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      69    117   150   165   206   226                                         |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                                   ALLYL BROMIDE                                                                                    
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE MICE                                                                                      
                       FIRST TERMINAL SACRIFICE AT 275 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                                DOSE = 2 MG/KG                                  |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 15     UNCENSORED DEATHS 2      CENSORED DEATHS 1    TERMINAL 12        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      142   165                                                                 |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      12                                                                        |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 4 MG/KG                                  |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 15     UNCENSORED DEATHS 8      CENSORED DEATHS 1    TERMINAL 6         |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      127   129   167   201   218   222   238   241                             |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      4                                                                         |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 8 MG/KG                                  |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 15     UNCENSORED DEATHS 3      CENSORED DEATHS 1    TERMINAL 11        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      107   108   243                                                           |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      5                                                                         |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                                   ALLYL BROMIDE                                                                                    
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE MICE                                                                                      
                       FIRST TERMINAL SACRIFICE AT 275 DAYS                                                                         
 ==================================================================================                                                 
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |    DOSE                               TIME (DAYS)                              |                                                 
 |                 28    56    84   112   140   168   196   224   252   275 (A)   |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |           |                                                                    |                                                 
 |VEHICLE    |   100.0 100.0 100.0 100.0 100.0 100.0  93.3  93.3  80.0  80.0      |                                                 
 |CONTROL    |                                                                    |                                                 
 |           |                                                                    |                                                 
 |0.5        |   100.0 100.0 100.0 100.0 100.0  92.9  78.6  64.3  64.3  64.3      |                                                 
 |MG/KG      |                                                                    |                                                 
 |           |                                                                    |                                                 
 |1 MG/KG    |   100.0 100.0  93.3  93.3  86.7  73.3  73.3  66.7  60.0  60.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |2 MG/KG    |   100.0 100.0 100.0 100.0 100.0  85.7  85.7  85.7  85.7  85.7      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |4 MG/KG    |   100.0 100.0 100.0 100.0  85.7  85.7  78.6  64.3  42.9  42.9      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |8 MG/KG    |   100.0 100.0 100.0  85.7  85.7  85.7  85.7  85.7  78.6  78.6      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                                   ALLYL BROMIDE                                                                                    
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE MICE                                                                                      
                       FIRST TERMINAL SACRIFICE AT 275 DAYS                                                                         
 ===============================================================================================================================    
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |    
 |                                                                                                                             |    
 |                                                                                                                             |    
 |-----------------------------------------------------------------------------------------------------------------------------|    
 |                                                                          DOSE                                               |    
 |                                                                                                                             |    
 |                                VEHICLE         0.5             1 MG/KG         2 MG/KG         4 MG/KG         8 MG/KG      |    
 |                                CONTROL         MG/KG                                                                        |    
 |-----------------------------------------------------------------------------------------------------------------------------|    
 |SURVIVAL AT END OF STUDY|       80.0%           64.3%           60.0%           85.7%           42.9%           78.6%        |    
 |(KAPLAN-MEIER)          |                                                                                                    |    
 |                        |                                                                                                    |    
 |SIGNIFICANCE (B)        |       P=1.000         P=0.480         P=0.304         P=1.000N        P=0.055         P=1.000      |    
 |(LIFE TABLE)            |                                                                                                    |    
 |                        |                                                                                                    |    
 |MEAN DAY OF             |       219.7           188.6           155.5           153.5           192.9           152.7        |    
 |NATURAL DEATHS (C)      |       (23.4)          (10.7)          (23.5)          (11.5)          (16.4)          (45.2)       |    
 |(STANDARD ERROR)        |                                                                                                    |    
 |                        |                                                                                                    |    
 |MEAN LIFE SPAN (D)      |       263.9           228.4           227.2           241.3           213.1           232.5        |    
 |(STANDARD ERROR)        |       ( 7.1)          (19.3)          (18.0)          (19.7)          (20.1)          (22.1)       |    
 |                        |                                                                                                    |    
 ===============================================================================================================================    
                                                                                                                                    
       (A)  FIRST TERMINAL SACRIFICE                                                                                                
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.                                                                
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS                                                                    
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".                                                                      
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE                                                               
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)                                                           
                                                                                                                                   
                                   ALLYL BROMIDE                                                                                    
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE MICE                                                                                     
                       FIRST TERMINAL SACRIFICE AT 275 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                          DOSE = VEHICLE CONTROL                                |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 15     UNCENSORED DEATHS 4      CENSORED DEATHS 2    TERMINAL 9         |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      151   154   229   263                                                     |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      214   217                                                                 |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                          DOSE = 0.5     MG/KG                                  |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 15     UNCENSORED DEATHS 5      CENSORED DEATHS 0    TERMINAL 10        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      147   162   200   218   219                                               |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 1 MG/KG                                  |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 15     UNCENSORED DEATHS 7      CENSORED DEATHS 0    TERMINAL 8         |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      102   149   164   193   194   234   246                                   |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                                   ALLYL BROMIDE                                                                                    
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE MICE                                                                                     
                       FIRST TERMINAL SACRIFICE AT 275 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                                DOSE = 2 MG/KG                                  |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 15     UNCENSORED DEATHS 7      CENSORED DEATHS 0    TERMINAL 8         |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      136   193   196   215   241   242   246                                   |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 4 MG/KG                                  |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 15     UNCENSORED DEATHS 4      CENSORED DEATHS 0    TERMINAL 11        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      86    188   200   216                                                     |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 8 MG/KG                                  |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 15     UNCENSORED DEATHS 3      CENSORED DEATHS 0    TERMINAL 12        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      213   241   246                                                           |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                                   ALLYL BROMIDE                                                                                    
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE MICE                                                                                     
                       FIRST TERMINAL SACRIFICE AT 275 DAYS                                                                         
 ==================================================================================                                                 
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |    DOSE                               TIME (DAYS)                              |                                                 
 |                 28    56    84   112   140   168   196   224   252   275 (A)   |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |           |                                                                    |                                                 
 |VEHICLE    |   100.0 100.0 100.0 100.0 100.0  86.7  86.7  86.7  78.8  70.9      |                                                 
 |CONTROL    |                                                                    |                                                 
 |           |                                                                    |                                                 
 |0.5        |   100.0 100.0 100.0 100.0 100.0  86.7  86.7  66.7  66.7  66.7      |                                                 
 |MG/KG      |                                                                    |                                                 
 |           |                                                                    |                                                 
 |1 MG/KG    |   100.0 100.0 100.0  93.3  93.3  80.0  80.0  66.7  53.3  53.3      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |2 MG/KG    |   100.0 100.0 100.0 100.0  93.3  93.3  93.3  73.3  53.3  53.3      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |4 MG/KG    |   100.0 100.0 100.0  93.3  93.3  93.3  86.7  73.3  73.3  73.3      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |8 MG/KG    |   100.0 100.0 100.0 100.0 100.0 100.0 100.0  93.3  80.0  80.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                                   ALLYL BROMIDE                                                                                    
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE MICE                                                                                     
                       FIRST TERMINAL SACRIFICE AT 275 DAYS                                                                         
 ===============================================================================================================================    
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |    
 |                                                                                                                             |    
 |                                                                                                                             |    
 |-----------------------------------------------------------------------------------------------------------------------------|    
 |                                                                          DOSE                                               |    
 |                                                                                                                             |    
 |                                VEHICLE         0.5             1 MG/KG         2 MG/KG         4 MG/KG         8 MG/KG      |    
 |                                CONTROL         MG/KG                                                                        |    
 |-----------------------------------------------------------------------------------------------------------------------------|    
 |SURVIVAL AT END OF STUDY|       70.9%           66.7%           53.3%           53.3%           73.3%           80.0%        |    
 |(KAPLAN-MEIER)          |                                                                                                    |    
 |                        |                                                                                                    |    
 |SIGNIFICANCE (B)        |       P=0.265N        P=1.000         P=0.454         P=0.524         P=1.000N        P=0.816N     |    
 |(LIFE TABLE)            |                                                                                                    |    
 |                        |                                                                                                    |    
 |MEAN DAY OF             |       199.3           189.2           183.1           209.9           172.5           233.3        |    
 |NATURAL DEATHS (C)      |       (27.9)          (14.8)          (18.8)          (14.9)          (29.4)          (10.3)       |    
 |(STANDARD ERROR)        |                                                                                                    |    
 |                        |                                                                                                    |    
 |MEAN LIFE SPAN (D)      |       246.9           246.4           232.1           244.6           247.7           266.7        |    
 |(STANDARD ERROR)        |       (11.4)          (11.7)          (14.9)          (10.9)          (14.0)          ( 4.8)       |    
 |                        |                                                                                                    |    
 ===============================================================================================================================    
                                                                                                                                    
       (A)  FIRST TERMINAL SACRIFICE                                                                                                
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.                                                                
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS                                                                    
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".                                                                      
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE                                                               
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)                                                           
                                                                                                                                   
                                                           ALLYL BROMIDE                                                            
                                                    KAPLAN-MEIER SURVIVAL CURVES                                                    
                                                        VEHICLE CONTROL  = 1                                                        
                                                        0.5     MG/KG    = 2                                                        
                                                        1 MG/KG          = 3                                                        
                                                        2 MG/KG          = 4                                                        
                                                        4 MG/KG          = 5                                                        
                                                        8 MG/KG          = 6                                                        
                                                                                                                                    
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
                                                                                                                                    
                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.                                           
                                                                                                                                    
      |                                                                                                                             
      |                                                                                                                             
  100 +  1                             3                 6        5     4        2  1                                               
      |                                                                                                                             
      |                                                                                                                             
      |                                3                    3           4        2  1                             1                 
P  90 +                                                                                                                             
E     |                                                     3              3                                                        
R     |                                                  6        5              4  2     2                       6              4  
C     |                                                                                                                             
E  80 +                                                                    3     3                                1              1  
N     |                                                                          5        2     5  2              6              6  
T     |                                                                                                                             
      |                                                                          3              5  2     2                          
S  70 +                                                                                                                             
U     |                                                                                            3        3                       
R     |                                                                                                  2                       2  
V     |                                                                                                                             
I  60 +                                                                                                     3                    3  
V     |                                                                                                  5     5                    
A     |                                                                                                                             
L     |                                                                                                                             
   50 +                                                                                                        5  5                 
      |                                                                                                                             
      |                                                                                                                             
      |                                                                                                           5              5  
   40 +                                                                                                                             
      |                                                                                                                             
      ---+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--
         0  1  2  3  4  5  6  7  8  9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40  
                                                                                                                                    
                                                                   WEEK                                                             
                                                                                                                                    
NOTE: 10 obs hidden.                                                                                                                
                                                                                                                                   
                                                           ALLYL BROMIDE                                                            
                                                    KAPLAN-MEIER SURVIVAL CURVES                                                    
                                                        VEHICLE CONTROL  = 1                                                        
                                                        0.5     MG/KG    = 2                                                        
                                                        1 MG/KG          = 3                                                        
                                                        2 MG/KG          = 4                                                        
                                                        4 MG/KG          = 5                                                        
                                                        8 MG/KG          = 6                                                        
                                                                                                                                    
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
                                                                                                                                    
                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.                                           
                                                                                                                                    
  100 +  1                                      5     3              4  2  1                          6                             
      |                                                                                                                             
      |                                                                                                                             
      |                                                                                                                             
   95 +                                                                                                                             
      |                                         5     3              4  2  3     2        5  4        6           6                 
      |                                                                                                                             
      |                                                                                                                             
   90 +                                                                                                                             
      |                                                                                                                             
      |                                                                                                                             
      |                                                                    1     2        5     2           1     6  6              
P  85 +                                                                                                                             
E     |                                                                                                                             
R     |                                                                                                                             
C     |                                                                                                                             
E  80 +                                                                          3           3  2     4  2           6           6  
N     |                                                                                                     1              1        
T     |                                                                                                                             
      |                                                                                                                             
S  75 +                                                                                                                             
U     |                                                                                               4           4              5  
R     |                                                                                                                             
V     |                                                                                                                    1     1  
I  70 +                                                                                                                             
V     |                                                                                                                             
A     |                                                                                                                             
L     |                                                                                      3           2     3                 2  
   65 +                                                                                                                             
      |                                                                                                                             
      |                                                                                                                             
      |                                                                                                                             
   60 +                                                                                                        3  4  3              
      |                                                                                                                             
      |                                                                                                                             
      |                                                                                                                             
   55 +                                                                                                                             
      |                                                                                                              3           3  
      |                                                                                                                             
      |                                                                                                                             
   50 +                                                                                                                             
      ---+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--
         0  1  2  3  4  5  6  7  8  9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40  
                                                                                                                                    
                                                                   WEEK                                                             
                                                                                                                                    
NOTE: 15 obs hidden.                                                                                                                
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.