National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/13682

TDMS Study 96018-03 Pathology Tables

NTP Experiment-Test: 96018-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 05/24/04
Route: DOSED WATER                           WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                 Time: 10:03:04

                                                         FINAL #2/RATS




       Facility:  Southern Research Institute

       Chemical CAS #:  75-27-4

       Lock Date:  02/19/02

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 96018-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 05/24/04    
Route: DOSED WATER                           WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                 Time: 10:03:04    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                16           19           14           15                                     
    Natural Death                                      5            2            7            9                                     
    Accidently Killed                                               1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           27           29           26                                     
    Moribund Sacrifice                                 1            1                                                               
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (46)         (49)         (44)         (43)                                   
      Edema                                                                      1 [2.0]                                            
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis, Focal                               4 [2.0]      4 [2.0]      5 [2.0]      2 [1.5]                               
      Basophilic Focus                                33           25           24           17                                     
      Cholangiofibrosis                                1 [2.0]      2 [2.0]      1 [3.0]      1 [2.0]                               
      Clear Cell Focus                                28           24           19           17                                     
      Congestion                                       2 [2.5]      1 [2.0]      1 [3.0]      4 [2.8]                               
      Degeneration, Cystic, Focal                     31 [1.9]     24 [1.8]     23 [1.7]     29 [1.8]                               
      Eosinophilic Focus                                            1            4                                                  
      Fibrosis, Focal                                  1 [3.0]      1 [2.0]      1 [2.0]      3 [2.7]                               
      Hemorrhage, Focal                                                                       1 [3.0]                               
      Hepatodiaphragmatic Nodule                       5 [2.8]      5 [2.4]     12 [2.5]      4 [2.3]                               
      Hyperplasia, Focal, Histiocytic                                            1 [2.0]                                            
      Hyperplasia, Focal, Regenerative                                                        1 [4.0]                               
      Infiltration Cellular, Mixed Cell               30 [1.9]     31 [1.8]     34 [1.8]     34 [1.9]                               
      Inflammation, Chronic                           23 [1.3]     29 [1.3]     33 [1.4]     34 [1.5]                               
      Mixed Cell Focus                                              3           10            4                                     
      Necrosis, Focal                                  2 [1.0]                                1 [2.0]                               
      Tension Lipidosis                                                          1 [3.0]                                            
      Bile Duct, Hyperplasia                          45 [2.8]     49 [2.7]     49 [2.7]     50 [2.8]                               
      Hepatocyte, Fatty Change                        36 [1.5]     34 [1.4]     36 [1.5]     40 [1.6]                               
      Hepatocyte, Hyperplasia, Regenerative                                                   1 [1.0]                               
      Hepatocyte, Hypertrophy                                       1 [3.0]                                                         
      Hepatocyte, Vacuolization Cytoplasmic           11 [2.0]     10 [2.0]     19 [1.5]     18 [1.4]                               
      Hepatocyte, Centrilobular, Necrosis              1 [3.0]      1 [2.0]      1 [3.0]      4 [2.5]                               
      Serosa, Bile Duct, Inflammation, Chronic,                                                                                     
         Focal                                                                                1 [2.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96018-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 05/24/04    
Route: DOSED WATER                           WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                 Time: 10:03:04    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Mesentery                                          (15)         (13)         (14)         (15)                                   
      Hemorrhage, Focal                                                                       1 [3.0]                               
      Inflammation, Chronic                            1 [3.0]                   1 [2.0]                                            
      Fat, Necrosis, Focal                             8 [2.6]      4 [3.0]      9 [2.7]      7 [2.9]                               
   Pancreas                                           (49)         (50)         (50)         (49)                                   
      Cyst                                                                       1 [3.0]                                            
      Hyperplasia, Focal, Histiocytic                                                         1 [1.0]                               
      Acinus, Atrophy, Focal                          31 [1.8]     20 [1.8]     23 [1.8]     21 [2.0]                               
      Acinus, Hyperplasia, Focal                       1 [2.0]                                                                      
      Duct, Cyst                                       1 [2.0]                                                                      
      Duct, Cyst, Focal, Multiple                     16 [1.8]     14 [1.4]     17 [1.5]     11 [1.5]                               
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Edema                                            2 [2.5]      2 [3.0]      3 [3.0]      4 [2.8]                               
      Erosion                                                                                 1 [1.0]                               
      Inflammation, Chronic, Diffuse                                             1 [3.0]                                            
      Inflammation, Diffuse                                                      2 [2.0]                                            
      Inflammation, Focal                              1 [2.0]      2 [2.5]      2 [2.5]      1 [2.0]                               
      Ulcer                                            1 [3.0]      4 [2.8]      4 [2.0]      4 [2.3]                               
      Epithelium, Hyperplasia                          2 [2.0]      5 [2.4]      4 [2.8]      6 [1.8]                               
   Stomach, Glandular                                 (49)         (50)         (50)         (50)                                   
      Atypia Cellular, Focal                                                     1 [2.0]                                            
      Edema                                                         1 [2.0]                                                         
      Erosion                                          2 [1.5]      4 [2.0]      1 [3.0]      4 [2.0]                               
      Fibrosis, Focal                                                                         1 [3.0]                               
      Infarct                                                       1 [2.0]                                                         
      Inflammation, Focal                                           1 [3.0]                                                         
      Pigmentation, Focal                                           1 [3.0]                   1 [2.0]                               
      Ulcer                                            1 [1.0]                                                                      
      Artery, Inflammation, Chronic                                 1 [3.0]                                                         
      Epithelium, Hyperplasia                                                                 2 [2.0]                               
      Epithelium, Hyperplasia, Focal                   1 [2.0]                                                                      
      Glands, Ectasia, Focal                                        1 [1.0]                   1 [3.0]                               
      Glands, Necrosis, Focal                                       1 [2.0]                                                         
   Tongue                                             (1)          (1)          (1)          (1)                                    
      Infiltration Cellular, Focal, Mixed Cell                      1 [2.0]                                                         
      Epithelium, Hyperplasia, Focal                                             1 [2.0]                                            
   Tooth                                                           (1)                                                              
      Epithelium Alveolus, Hyperplasia                              1 [3.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96018-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 05/24/04    
Route: DOSED WATER                           WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                 Time: 10:03:04    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Cardiomyopathy                                  16 [1.8]     18 [1.8]     21 [1.7]     14 [1.9]                               
      Fibrosis, Focal                                                            1 [2.0]                                            
      Infiltration Cellular, Mixed Cell                1 [1.0]                                                                      
      Thrombosis                                                    2 [3.5]                   2 [2.5]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (49)                                   
      Accessory Adrenal Cortical Nodule               14 [1.0]      8 [1.1]      8 [1.4]     14 [1.1]                               
      Angiectasis                                                                1 [2.0]                                            
      Cytoplasmic Alteration, Focal                    1 [2.0]      3 [1.7]      3 [1.7]      2 [1.0]                               
      Infiltration Cellular, Mixed Cell                             1 [2.0]                                                         
      Necrosis, Focal                                  2 [2.0]                   1 [3.0]      1 [2.0]                               
      Vacuolization Cytoplasmic, Focal                 9 [1.2]      5 [1.0]      8 [1.4]     12 [1.2]                               
   Adrenal Medulla                                    (50)         (50)         (50)         (49)                                   
      Cytoplasmic Alteration, Focal                                                           1 [1.0]                               
      Hemorrhage                                                                 1 [4.0]                                            
      Hyperplasia                                                                             1 [1.0]                               
      Hyperplasia, Focal                              11 [1.2]     17 [1.7]     15 [1.3]     13 [1.5]                               
      Necrosis, Focal                                  1 [3.0]                   1 [2.0]                                            
      Thrombosis                                                                              1 [3.0]                               
      Bilateral, Hyperplasia, Focal                                 1 [4.0]                                                         
   Islets, Pancreatic                                 (49)         (50)         (50)         (49)                                   
      Hyperplasia                                                   1 [2.0]      1 [2.0]      1 [2.0]                               
      Hyperplasia, Focal                               2 [2.0]                                                                      
   Parathyroid Gland                                  (48)         (49)         (50)         (50)                                   
      Cyst                                                                                    1 [3.0]                               
      Hyperplasia, Focal                                                         1 [2.0]                                            
   Pituitary Gland                                    (49)         (50)         (50)         (48)                                   
      Angiectasis                                      2 [2.0]      2 [2.0]                   1 [2.0]                               
      Craniopharyngeal Duct, Cyst                      1 [2.0]                                                                      
      Pars Distalis, Cyst                              2 [2.0]      2 [2.5]      2 [1.5]      2 [1.5]                               
      Pars Distalis, Cytoplasmic Alteration, Focal     7 [1.4]      6 [1.2]      1 [2.0]      6 [1.0]                               
      Pars Distalis, Degeneration, Cystic, Focal       1 [1.0]                                3 [2.0]                               
      Pars Distalis, Hemorrhage, Focal                 3 [2.3]      5 [2.0]      1 [3.0]      3 [2.7]                               
      Pars Distalis, Hyperplasia, Focal                3 [2.0]      2 [2.0]      2 [2.0]      7 [2.1]                               
      Pars Distalis, Necrosis, Focal                   1 [3.0]                                                                      
      Pars Intermedia, Cyst                                         1 [1.0]                                                         
      Rathke's Cleft, Cyst                             2 [2.0]      2 [2.5]                                                         
      Rathke's Cleft, Hemorrhage                                                 1 [2.0]                                            
   Thyroid Gland                                      (46)         (48)         (44)         (42)                                   
      Hemorrhage                                                                 1 [2.0]                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96018-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 05/24/04    
Route: DOSED WATER                           WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                 Time: 10:03:04    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      C-Cell, Hyperplasia                             44 [1.9]     46 [1.6]     40 [1.6]     41 [1.7]                               
      Follicle, Degeneration, Cystic, Focal                         2 [2.0]                                                         
      Follicular Cell, Hyperplasia                                                            2 [1.0]                               
      Follicular Cell, Hyperplasia, Cystic, Focal      5 [1.4]      4 [1.8]      4 [1.5]      3 [2.3]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (50)         (50)         (50)                                   
      Inflammation, Chronic                            1 [3.0]                                                                      
   Preputial Gland                                    (50)         (50)         (50)         (49)                                   
      Degeneration, Cystic                             1 [3.0]                   1 [3.0]      2 [2.5]                               
      Fibrosis                                                                                1 [3.0]                               
      Hyperplasia, Cystic                              2 [3.5]      1 [3.0]      1 [2.0]      2 [2.0]                               
      Inflammation, Chronic                           32 [1.7]     30 [1.4]     31 [1.5]     37 [1.7]                               
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic                           29 [2.2]     33 [2.0]     35 [2.2]     38 [2.2]                               
      Mineralization, Focal                                                                   2 [2.0]                               
      Epithelium, Hyperplasia, Focal                  25 [1.4]     21 [1.6]     24 [1.5]     23 [1.6]                               
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Dilatation                                                                 1 [3.0]                                            
      Inflammation, Chronic                                                      1 [3.0]                                            
   Testes                                             (50)         (50)         (50)         (50)                                   
      Atrophy                                          5 [3.0]      8 [2.8]      8 [3.0]      8 [3.0]                               
      Necrosis                                         1 [4.0]                                                                      
      Artery, Thrombosis, Focal                        1 [3.0]                                                                      
      Bilateral, Atrophy                               1 [2.0]                   1 [3.0]      1 [4.0]                               
      Bilateral, Interstitial Cell, Hyperplasia,                                                                                    
         Focal                                                      1 [1.0]                                                         
      Interstitial Cell, Hyperplasia                                             1 [1.0]                                            
      Interstitial Cell, Hyperplasia, Focal            3 [1.7]      1 [1.0]      3 [1.7]      3 [2.0]                               
      Tunic, Inflammation, Chronic                     1 [3.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (45)         (49)         (49)                                   
      Hyperplasia                                      2 [3.5]      2 [3.5]      5 [3.2]      2 [3.5]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96018-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 05/24/04    
Route: DOSED WATER                           WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                 Time: 10:03:04    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Focal, Histiocytic                               1 [1.0]                   1 [1.0]                               
      Hyperplasia, Histiocytic                                      1 [4.0]                                                         
      Myeloid Cell, Hyperplasia                        2 [2.5]                   3 [2.7]      1 [3.0]                               
      Myeloid Cell, Erythroid Cell, Hyperplasia        1 [3.0]      5 [2.8]                   5 [2.8]                               
   Lymph Node                                         (25)         (28)         (26)         (26)                                   
      Bronchial, Hyperplasia, Plasma Cell                           1 [3.0]                                                         
      Deep Cervical, Ectasia                                                                  1 [3.0]                               
      Mediastinal, Angiectasis                         2 [3.5]                                1 [3.0]                               
      Mediastinal, Ectasia                             3 [3.0]      1 [3.0]      3 [3.0]      4 [3.0]                               
      Mediastinal, Hemorrhage                                                    1 [3.0]      2 [2.5]                               
      Mediastinal, Hyperplasia                                      1 [3.0]                                                         
      Mediastinal, Hyperplasia, Histiocytic            2 [3.0]                   1 [3.0]      2 [3.0]                               
      Mediastinal, Hyperplasia, Lymphoid               1 [3.0]      1 [3.0]      1 [3.0]                                            
      Mediastinal, Hyperplasia, Plasma Cell            1 [3.0]      3 [3.3]      6 [3.2]      1 [3.0]                               
      Mediastinal, Inflammation                        1 [4.0]                                                                      
      Pancreatic, Angiectasis                                                                 1 [3.0]                               
      Pancreatic, Ectasia                              3 [3.0]      5 [3.0]      3 [3.0]      5 [3.0]                               
      Pancreatic, Hemorrhage                           1 [3.0]                   2 [2.5]      1 [3.0]                               
      Pancreatic, Hyperplasia, Histiocytic             3 [3.0]      7 [2.7]                   5 [3.0]                               
      Pancreatic, Pigmentation                         1 [3.0]                   1 [2.0]      1 [2.0]                               
   Lymph Node, Mesenteric                             (50)         (49)         (50)         (50)                                   
      Ectasia                                                       1 [3.0]                                                         
      Hemorrhage                                       2 [2.5]                                1 [3.0]                               
      Hyperplasia, Histiocytic                                      2 [3.0]                   1 [3.0]                               
   Spleen                                             (48)         (49)         (49)         (50)                                   
      Accessory Spleen                                 1                         1            1                                     
      Angiectasis, Focal                               1 [2.0]      2 [3.0]                                                         
      Congestion                                                    1 [3.0]      1 [2.0]                                            
      Fibrosis, Focal                                  4 [2.5]      3 [2.7]      1 [3.0]      1 [2.0]                               
      Hematopoietic Cell Proliferation                 6 [2.2]      7 [2.3]      5 [2.2]     11 [2.3]                               
      Hemorrhage                                                                              2 [3.0]                               
      Hemorrhage, Chronic                              1 [3.0]                                                                      
      Hyperplasia, Focal, Histiocytic                               1 [4.0]                                                         
      Hyperplasia, Lymphoid                            1 [2.0]                                                                      
      Infarct                                          2 [3.0]      1 [3.0]      1 [3.0]                                            
      Necrosis, Focal                                                                         1 [3.0]                               
      Pigmentation                                                               1 [4.0]                                            
      Artery, Thrombosis                               1 [4.0]                                                                      
      Capsule, Fibrosis, Focal                         1 [2.0]                                                                      
   Thymus                                             (48)         (48)         (50)         (47)                                   
      Hemorrhage                                                                 1 [2.0]                                            
      Hyperplasia, Lymphoid                                                      1 [3.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96018-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 05/24/04    
Route: DOSED WATER                           WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                 Time: 10:03:04    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (44)         (45)         (47)         (42)                                   
      Atypia Cellular, Focal                                                     1 [2.0]                                            
      Dilatation                                       8 [2.4]     18 [2.4]     16 [2.4]     12 [2.3]                               
      Ectasia                                                                    1 [2.0]      1 [2.0]                               
      Fibrosis                                                      1 [2.0]                                                         
      Fibrosis, Focal                                                                         1 [3.0]                               
      Hyperplasia                                      2 [2.0]      3 [2.7]      2 [2.0]      1 [3.0]                               
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                                                               2                                     
      Hyperkeratosis, Focal                                                                   1 [2.0]                               
      Inflammation, Chronic, Focal                                               1 [3.0]                                            
      Mineralization, Focal                                                      1 [3.0]                                            
      Subcutaneous Tissue, Angiectasis, Focal          1 [2.0]      1 [2.0]                                                         
      Subcutaneous Tissue, Cyst, Chronic               1 [4.0]                                                                      
      Subcutaneous Tissue, Cyst Epithelial                                                                                          
        Inclusion                                                                1 [2.0]                                            
      Subcutaneous Tissue, Edema                       1 [3.0]                                                                      
      Subcutaneous Tissue, Hemorrhage, Focal           1 [2.0]                   1 [3.0]      1 [3.0]                               
      Subcutaneous Tissue, Inflammation, Focal,                                                                                     
         Granulomatous                                                           1 [2.0]                                            
      Subcutaneous Tissue, Metaplasia, Focal,                                                                                       
        Osseous                                        1 [2.0]                                                                      
      Subcutaneous Tissue, Necrosis, Fatty, Focal                                             1 [2.0]                               
      Subcutaneous Tissue, Epidermis, Hyperplasia,                                                                                  
         Focal                                                                   1 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Hyperostosis                                                  1 [2.0]                                                         
   Skeletal Muscle                                    (3)                                    (2)                                    
      Hemorrhage, Focal                                                                       1 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Compression, Focal                               6 [2.5]      8 [2.9]     14 [3.1]     14 [2.8]                               
      Hemorrhage, Focal                                2 [1.5]      4 [2.8]      1 [3.0]      3 [2.7]                               
      Hydrocephalus                                                              2 [3.0]                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 96018-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 05/24/04    
Route: DOSED WATER                           WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                 Time: 10:03:04    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - CONT                                                                                                               
      Necrosis, Focal                                  1 [2.0]      2 [3.0]                                                         
      Cerebellum, Hemorrhage, Focal                                              1 [1.0]                                            
      Cerebrum, Ventricle, Hydrocephalus                            1 [3.0]                                                         
      Pineal Gland, Vacuolization Cytoplasmic                                    1 [3.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                       4 [2.8]      1 [2.0]      3 [3.0]      5 [2.4]                               
      Fibrosis, Focal                                                                         1 [2.0]                               
      Hemorrhage                                       1 [2.0]      1 [3.0]                   1 [3.0]                               
      Hemorrhage, Focal                                3 [1.7]      1 [2.0]      2 [1.5]      2 [2.0]                               
      Hyperplasia, Focal, Histiocytic                  1 [3.0]      1 [1.0]                                                         
      Hyperplasia, Histiocytic                         1 [1.0]      1 [1.0]                   2 [1.0]                               
      Infiltration Cellular, Mixed Cell                2 [1.5]                                1 [2.0]                               
      Inflammation, Chronic, Focal                                  2 [1.5]      3 [1.7]      2 [1.0]                               
      Metaplasia, Squamous                                          1 [4.0]                                                         
      Alveolar Epithelium, Hyperplasia, Focal          7 [1.7]      6 [1.7]      9 [1.4]      5 [2.2]                               
      Interstitium, Edema                              1 [3.0]                                                                      
      Mediastinum, Angiectasis, Focal                                                         1 [2.0]                               
   Nose                                               (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                    1 [3.0]                                                         
      Inflammation, Suppurative                        2 [2.0]      3 [2.0]      3 [1.7]      3 [1.3]                               
      Nasolacrimal Duct, Inflammation                                            3 [2.3]      1 [1.0]                               
      Olfactory Epithelium, Mineralization, Focal                                             1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (49)         (49)         (48)         (47)                                   
      Cataract                                         2 [3.0]      1 [3.0]      7 [2.9]                                            
      Inflammation, Chronic                                                      1 [3.0]                                            
      Retina, Degeneration                             3 [3.0]      1 [3.0]      8 [2.8]      1 [3.0]                               
   Harderian Gland                                    (50)         (50)         (50)         (48)                                   
      Hyperplasia, Focal, Histiocytic                                            1 [2.0]                                            
      Hyperplasia, Focal, Lymphoid                                               1 [2.0]                                            
      Hyperplasia, Lymphoid                            1 [2.0]                                                                      
      Inflammation, Chronic, Focal                     1 [1.0]                   1 [2.0]                                            
      Epithelium, Hyperplasia, Focal                                             1 [1.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 96018-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 05/24/04    
Route: DOSED WATER                           WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                 Time: 10:03:04    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)         (49)                                   
      Cyst                                                                                    1 [2.0]                               
      Infarct                                                       3 [3.3]      1 [3.0]                                            
      Metaplasia, Focal, Osseous                                                 1 [2.0]                                            
      Nephropathy                                     49 [2.1]     50 [1.8]     49 [2.0]     46 [1.8]                               
      Artery, Thrombosis                                            1 [3.0]                                                         
      Cortex, Necrosis, Focal                                                                 1 [2.0]                               
      Pelvis, Dilatation                                                         1 [3.0]                                            
      Pelvis, Transitional Epithelium, Hyperplasia                                            1 [2.0]                               
      Renal Tubule, Hyperplasia, Atypical, Focal                                              1 [1.0]                               
      Renal Tubule, Pigmentation                      10 [2.1]     13 [2.2]      7 [2.3]      3 [2.3]                               
   Urinary Bladder                                    (49)         (50)         (50)         (49)                                   
      Hemorrhage                                                    1 [3.0]      1 [3.0]                                            
      Inflammation, Chronic                                                      1 [3.0]                                            
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.