National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/13686

TDMS Study 96018-04 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Southern Research Inst           WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                          DATE: 03/31/03  
EXPERIMENT: 96018 TEST: 04                                                                                        TIME: 09:23:15    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED WATER                                            NTP:  C96018      
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: SOUTHERN RESEARCH INSTITUTE                      WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)        DATE: 03/31/03    
EXPERIMENT: 96018 TEST: 04                                                                                        TIME:  9:27:04    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: CHRONIC                                  ROUTE: DOSED WATER                                            NTP:  C96018      
CONT: N01-ES-85420                                                                                                CAS: 75-27-4      
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                      
                           CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                        
==================================================================================================================================  
           0 MG/L                     175 MG/L                           350 MG/L                           700 MG/L                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  4     3.0    21.7       2.2     20.8    0.73       19      1.7     20.1    0.57       29      1.9     20.1    0.63       66       
  8     3.4    26.4       2.3     24.2    0.68       17      2.5     24.6    0.74       36      2.1     24.4    0.62       61       
 12     2.9    32.1       2.5     27.2    0.86       16      2.6     28.2    0.90       32      2.3     27.3    0.79       59       
 16     2.2    37.9       2.0     31.8    0.91       11      1.6     33.3    0.73       17      2.2     31.7    1.00       48       
 20     2.6    42.6       2.5     34.8    0.96       12      2.2     37.2    0.85       21      2.5     35.5    0.96       50       
 24     2.7    45.9       2.4     37.8    0.89       11      2.3     38.5    0.85       21      2.8     37.3    1.04       53       
 28     1.9    50.0       2.2     40.1    1.16       10      2.2     41.4    1.16       18      1.9     40.4    1.00       33       
 32     2.4    51.8       2.2     43.8    0.92        9      2.2     45.4    0.92       17      2.3     43.7    0.96       37       
 36     2.4    54.8       2.2     46.6    0.92        8      2.3     48.2    0.96       17      2.2     47.4    0.92       32       
 40     2.5    58.1       2.5     50.6    1.00        9      2.3     52.8    0.92       15      2.4     51.3    0.96       33       
 44     2.6    59.4       2.4     54.6    0.92        8      2.3     55.7    0.88       14      2.4     54.3    0.92       31       
 48     2.7    60.2       2.5     57.0    0.93        8      2.2     58.4    0.81       13      2.2     56.4    0.81       27       
 52     2.7    61.2       2.5     58.1    0.93        7      2.4     58.1    0.89       14      2.5     55.6    0.93       31       
 56     2.6    62.3       2.1     57.3    0.81        6      2.1     58.8    0.81       12      2.1     56.3    0.81       27       
 60     2.5    64.4       2.3     58.3    0.92        7      2.0     61.2    0.80       12      2.2     58.3    0.88       27       
 64     2.7    64.7       2.2     60.0    0.81        6      2.1     60.5    0.78       12      2.2     59.9    0.81       26       
 68     2.7    65.4       2.1     60.8    0.78        6      2.2     61.4    0.81       12      2.2     60.3    0.81       25       
 72     2.9    66.6       2.1     62.2    0.72        6      2.2     62.7    0.76       12      2.2     61.4    0.76       25       
 76     2.6    66.6       2.0     61.3    0.77        6      2.0     61.7    0.77       11      2.3     60.1    0.88       26       
 80     2.9    65.1       2.3     59.2    0.79        7      2.1     60.1    0.72       12      2.2     59.1    0.76       27       
 84     2.9    65.4       2.2     59.9    0.76        6      2.2     60.7    0.76       13      2.4     59.3    0.83       28       
 88     3.3    66.1       2.2     61.2    0.67        6      2.4     60.9    0.73       14      2.3     60.9    0.70       26       
 92     3.7    64.0       2.4     59.8    0.65        7      2.3     59.4    0.62       13      2.4     59.6    0.65       28       
 96     3.6    62.2       3.2     56.5    0.89       10      2.5     55.8    0.69       16      2.4     57.3    0.67       29       
100     3.7    60.4       2.8     54.7    0.76        9      2.3     52.4    0.62       16      2.7     56.5    0.73       33       
104     3.8    56.9       3.0     53.8    0.79       10      3.4     51.8    0.89       23      2.8     55.3    0.74       35       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    3.1    26.7       2.4     24.1    0.76       17      2.3     24.3    0.73       33      2.1     23.9    0.68       62       
SD(D)   0.3               0.2             0.10        1      0.5             0.16        3      0.2             0.10        3       
CV(E)   8.5               6.6            12.6       7.8     22.0            22.5      10.6     10.3            14.2       5.3       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    2.5    52.2       2.3     45.5    0.95        9      2.2     46.9    0.90       17      2.3     45.4    0.95       38       
SD(D)   0.3               0.2             0.08        2      0.2             0.11        3      0.2             0.06        9       
CV(E)  11.1               7.5             8.2      18.9      9.7            12.5      15.4     10.5             6.4      24.5       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN    3.1    63.9       2.4     58.8    0.78        7      2.3     59.0    0.75       14      2.3     58.8    0.77       28       
SD(D)   0.5               0.4             0.08        1      0.4             0.08        3      0.2             0.08        3       
CV(E)  16.0              15.8             9.7      20.1     15.8            10.1      22.5      8.1             9.7      10.7       
==================================================================================================================================  
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
              DIAGNOSTIC TRAILER REPORT                                                                                             
              WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                                  
              CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                                     
=========================================================================================================                           
           0 MG/L                  175 MG/L                 350 MG/L                 700 MG/L                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM                              
WEEK WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS                             
==========================================================================================================                          
  B               18.6  50                 18.4  50                 18.6  50                 18.5  50                               
  1               18.6  50                 18.4  50                 18.6  50                 18.5  50                               
  4   3.0  8313   21.7  50     2.2  7836   20.8  50     1.7  8061   20.1  50     1.9  7704   20.1  50                               
  8   3.4  8018   26.4  50     2.3  6765   24.2  50     2.5  7922   24.6  50     2.1  7321   24.4  50                               
 12   2.9  7917   32.1  50     2.5  8035   27.2  50     2.6  7626   28.2  50     2.3  7939   27.3  50                               
 16   2.2  8258   37.9  50     2.0  4816   31.8  50     1.6  6386   33.3  50     2.2  5518   31.7  50                               
 20   2.6  8315   42.6  50     2.5  7334   34.8  50     2.2  7863   37.2  50     2.5  7326   35.5  50                               
 24   2.7  8206   45.9  50     2.4  6933   37.8  50     2.3  5411   38.5  50     2.8  5841   37.3  50                               
 28   1.9  8224   50.0  50     2.2  5756   40.1  50     2.2  7137   41.4  50     1.9  7989   40.4  50                               
 32   2.4  8280   51.8  50     2.2  8205   43.8  49     2.2  7427   45.4  50     2.3  8375   43.7  50                               
 36   2.4  7750   54.8  50     2.2  7951   46.6  49     2.3  7854   48.2  50     2.2  7355   47.4  50                               
 40   2.5  8205   58.1  50     2.5  8037   50.6  49     2.3  8195   52.8  50     2.4  8189   51.3  50                               
 44   2.6  8390   59.4  50     2.4  8212   54.6  49     2.3  8366   55.7  50     2.4  7748   54.3  50                               
 48   2.7  8257   60.2  50     2.5  7921   57.0  48     2.2  8095   58.4  49     2.2  8154   56.4  50                               
 52   2.7  7938   61.2  49     2.5  7875   58.1  48     2.4  8139   58.1  49     2.5  7799   55.6  50                               
 56   2.6  7848   62.3  49     2.1  6027   57.3  48     2.1  7319   58.8  49     2.1  6321   56.3  50                               
 60   2.5  7320   64.4  49     2.3  6680   58.3  48     2.0  7295   61.2  49     2.2  7354   58.3  50                               
 64   2.7  8035   64.7  48     2.2  8024   60.0  48     2.1  8182   60.5  49     2.2  7723   59.9  49                               
 68   2.7  8243   65.4  48     2.1  8234   60.8  48     2.2  8059   61.4  47     2.2  8298   60.3  49                               
 72   2.9  7559   66.6  48     2.1  7017   62.2  48     2.2  7636   62.7  46     2.2  7614   61.4  48                               
 76   2.6  7826   66.6  48     2.0  4372   61.3  46     2.0  7135   61.7  46     2.3  6124   60.1  47                               
 80   2.9  8074   65.1  48     2.3  6031   59.2  45     2.1  7423   60.1  45     2.2  5231   59.1  46                               
 84   2.9  7878   65.4  46     2.2  6495   59.9  44     2.2  7581   60.7  45     2.4  7842   59.3  46                               
 88   3.3  7186   66.1  44     2.2  6274   61.2  43     2.4  7016   60.9  43     2.3  6735   60.9  45                               
 92   3.7  7427   64.0  44     2.4  6921   59.8  42     2.3  6919   59.4  43     2.4  6929   59.6  44                               
 96   3.6  6993   62.2  43     3.2  4731   56.5  39     2.5  4491   55.8  38     2.4  5798   57.3  43                               
100   3.7  6321   60.4  41     2.8  4844   54.7  37     2.3  5162   52.4  36     2.7  5770   56.5  40                               
104   3.8  5740   56.9  38     3.0  5413   53.8  36     3.4  4692   51.8  33     2.8  5181   55.3  39                               
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           24.7                     22.7                     22.9                     22.6                                   
14 TO 52          52.2                     45.5                     46.9                     45.4                                   
 > 52             63.9                     58.8                     59.0                     58.8                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.