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TDMS Study 93021-04 Pathology Tables

NTP Experiment-Test: 93021-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                              DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97
Route: SKIN APPLICATION                                                                                           Time: 10:18:14

                                                       13 WEEK SUBCHRONIC




       Facility:  Microbiological Associates

       Chemical CAS #:  538-75-0

       Lock Date:  05/17/95

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 93021-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                              DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97  
Route: SKIN APPLICATION                                                                                           Time: 10:18:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0            1.5          3            6.0          12           24.0            
                                                   MG/KG        MG/KG        MG/KG        MG/KG        MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                                                                                 10           
  Survivors                                                                                                                         
    Terminal Sacrifice                                10            9           10           10           10                        
    Accidently Killed                                               1                                                               

  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)                                                (10)         (10)         
      Inflammation, Focal                              1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)                                                (10)         (10)         
      Bilateral, Capsule, Hyperplasia                  5 (50%)                                             7 (70%)                  
      Capsule, Hyperplasia                             2 (20%)                                             2 (20%)                  
   Pituitary Gland                                    (9)                                                 (9)          (8)          
      Pars Distalis, Cyst                                                                                               1 (13%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (8)          (7)          (5)          (9)          (7)          (10)         
      Bilateral, Atrophy                                                                                                1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 93021-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                              DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97  
Route: SKIN APPLICATION                                                                                           Time: 10:18:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0            1.5          3            6.0          12           24.0            
                                                   MG/KG        MG/KG        MG/KG        MG/KG        MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                                                                             (1)                       
      Inguinal, Hyperplasia                                                                                1 (100%)                 
   Spleen                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Hematopoietic Cell Proliferation                 2 (20%)      2 (20%)      7 (70%)      9 (90%)      5 (50%)      3 (30%)     
   Thymus                                             (10)         (10)         (10)         (9)          (10)         (8)          
      Atrophy                                                                                                           8 (100%)    
      Thymocyte, Necrosis                                                                                               1 (13%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Control, Inflammation                            1 (10%)                                                          1 (10%)     
      Control, Inflammation, Chronic Active            1 (10%)                   3 (30%)      5 (50%)      5 (50%)                  
      Epidermis, Control, Hyperplasia                                                                      3 (30%)                  
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia                                               5 (50%)      9 (90%)     10 (100%)    10 (100%)     3 (30%)     
      Epidermis, Skin, Site of Application,                                                                                         
          Necrosis                                                                            2 (20%)      3 (30%)     10 (100%)    
      Epidermis, Skin, Site of Application,                                                                                         
          Necrosis, Focal                                                                     1 (10%)                               
      Skin, Site of Application, Inflammation,                                                                                      
           Chronic Active                                           1 (10%)      9 (90%)     10 (100%)    10 (100%)    10 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Pons, Hemorrhage                                                                                                  6 (60%)     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 93021-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                              DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97  
Route: SKIN APPLICATION                                                                                           Time: 10:18:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0            1.5          3            6.0          12           24.0            
                                                   MG/KG        MG/KG        MG/KG        MG/KG        MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 93021-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                              DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97  
Route: SKIN APPLICATION                                                                                           Time: 10:18:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0            1.5          3            6.0          12           24.0            
                                                   MG/KG        MG/KG        MG/KG        MG/KG        MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                                                                                  9           
    Natural Death                                                                                                       1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                 9            9            8           10           10                        
    Accidently Killed                                  1            1            2                                                  

  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)                                                (10)         (10)         
      Inflammation, Focal                                                                                  1 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)                                                (10)         (9)          
      Bilateral, Capsule, Hyperplasia                  1 (10%)                                                                      
      Capsule, Hyperplasia                             1 (10%)                                             3 (30%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (9)          (10)         (10)         (10)         (10)         (10)         
      Atrophy                                                                                 1 (10%)                               
      Bilateral, Atrophy                                                                                                4 (40%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 93021-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                              DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97  
Route: SKIN APPLICATION                                                                                           Time: 10:18:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0            1.5          3            6.0          12           24.0            
                                                   MG/KG        MG/KG        MG/KG        MG/KG        MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Hematopoietic Cell Proliferation                              5 (50%)      2 (20%)      7 (70%)      6 (60%)      6 (60%)     
   Thymus                                             (9)          (10)         (9)          (9)          (10)         (8)          
      Atrophy                                                                                                           8 (100%)    
      Thymocyte, Necrosis                                                                                  1 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Hyperplasia                                                   1 (10%)                                                         
      Control, Inflammation                                                                                1 (10%)                  
      Control, Inflammation, Chronic Active                         1 (10%)      1 (10%)      1 (10%)      3 (30%)                  
      Epidermis, Control, Hyperplasia                                            1 (10%)                                            
      Epidermis, Control, Necrosis                                                                         2 (20%)                  
      Epidermis, Control, Necrosis, Diffuse                                                                1 (10%)                  
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia                                               7 (70%)     10 (100%)    10 (100%)    10 (100%)                 
      Epidermis, Skin, Site of Application,                                                                                         
          Necrosis                                     1 (10%)                                             2 (20%)     10 (100%)    
      Epidermis, Skin, Site of Application,                                                                                         
          Necrosis, Focal                                                                     2 (20%)                               
      Skin, Site of Application, Inflammation,                                                                                      
           Chronic Active                                           4 (40%)     10 (100%)    10 (100%)    10 (100%)    10 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Pons, Hemorrhage                                                                                                  2 (20%)     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 93021-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                              DICYCLOHEXYLCARBODIIMIDE                                 Date: 09/02/97  
Route: SKIN APPLICATION                                                                                           Time: 10:18:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0            1.5          3            6.0          12           24.0            
                                                   MG/KG        MG/KG        MG/KG        MG/KG        MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
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