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TDMS Study 92012-04 Pathology Tables

NTP Experiment-Test: 92012-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                 2-METHYLIMIDAZOLE                                     Date: 08/06/96
Route: DOSED FEED                                                                                                 Time: 20:32:14

                                                             90-DAY




       Facility:  Microbiological Associates

       Chemical CAS #:  693-98-1

       Lock Date:  08/31/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 92012-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                 2-METHYLIMIDAZOLE                                     Date: 08/06/96  
Route: DOSED FEED                                                                                                 Time: 20:32:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        UNTREAT      625          1250         2500         5000         10000           
                                                   CONTROL      PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10            9           10           10            8           
    Accidently Killed                                                            1                                      2           

  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)                      (1)                                    (10)         
      Infiltration Cellular, Lymphocyte                1 (10%)                                                                      
      Necrosis, Acute                                                                                                   1 (10%)     
      Vacuolization Cytoplasmic, Diffuse               1 (10%)                                                                      
      Periportal, Vacuolization Cytoplasmic            6 (60%)                                                          8 (80%)     
   Stomach, Glandular                                 (10)                      (1)                                    (10)         
      Infiltration Cellular, Mixed Cell                                                                                 1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Thyroid Gland                                      (10)         (9)          (8)          (9)          (10)         (10)         
      Follicular Cell, Hypertrophy                                                            7 (78%)     10 (100%)    10 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (9)                       (1)                                    (6)          
      Cyst                                             6 (67%)                                                          2 (33%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 92012-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                 2-METHYLIMIDAZOLE                                     Date: 08/06/96  
Route: DOSED FEED                                                                                                 Time: 20:32:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        UNTREAT      625          1250         2500         5000         10000           
                                                   CONTROL      PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Hematopoietic Cell Proliferation                 2 (20%)      1 (10%)      1 (10%)     10 (100%)    10 (100%)    10 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)                      (1)                                    (10)         
      Perivascular, Inflammation, Chronic Active       1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Pelvis, Infiltration Cellular, Lymphocyte        1 (10%)                                                                      
      Renal Tubule, Pigmentation, Hemosiderin                                                 3 (30%)      9 (90%)     10 (100%)    
   Urinary Bladder                                    (10)                      (1)                                    (10)         
      Infiltration Cellular, Lymphocyte                2 (20%)                                                                      
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 92012-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                 2-METHYLIMIDAZOLE                                     Date: 08/06/96  
Route: DOSED FEED                                                                                                 Time: 20:32:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          UNTREAT      625          1250         2500         5000         10000           
                                                   CONTROL      PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10            9            9           10           10            9           
    Accidently Killed                                               1            1                                      1           

  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (1)          (1)                                    (10)         
      Necrosis, Acute                                                                                                   1 (10%)     
      Periportal, Vacuolization Cytoplasmic            9 (90%)                   1 (100%)                              10 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Thyroid Gland                                      (10)         (9)          (10)         (9)          (10)         (10)         
      Follicular Cell, Hypertrophy                                                            9 (100%)    10 (100%)    10 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (10)         (1)          (1)                                    (10)         
      Cyst                                             7 (70%)                                                          3 (30%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Hematopoietic Cell Proliferation                              1 (10%)     10 (100%)    10 (100%)    10 (100%)    10 (100%)    
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 92012-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                 2-METHYLIMIDAZOLE                                     Date: 08/06/96  
Route: DOSED FEED                                                                                                 Time: 20:32:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          UNTREAT      625          1250         2500         5000         10000           
                                                   CONTROL      PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Nose                                               (10)         (1)          (1)                                    (10)         
      Respiratory Epithelium, Infiltration                                                                                          
          Cellular, Mixed Cell                                                                                          1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Cyst                                             1 (10%)                                                                      
      Renal Tubule, Pigmentation, Hemosiderin                                   10 (100%)    10 (100%)    10 (100%)    10 (100%)    
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
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