National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2373

TDMS Study 05002-06 Pathology Tables

NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97
Route: GAVAGE                                                                                                     Time: 12:54:45




       Facility:  Southern Research Institute

       Chemical CAS #:  96-48-0

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 3| 3| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 0| 7| 0| 0| 0| 0| 0| 0| 0| 3| 2| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                               X                                          |             
      Hepatocellular Adenoma               |                X                                                         |             
      Lymphoma Malignant Mixed             |       X     X  X                                                         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +           +                 +      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             |             X                                                            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |       X                                                                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |          X                                   X                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Spindle Cell, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                X         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X                                               X                     |             
      Pars Intermedia, Adenoma             |                X                                                         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 3| 3| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 0| 7| 0| 0| 0| 0| 0| 0| 0| 3| 2| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Cystadenoma                          | X                                                                        |             
      Granulosa-Theca Tumor Malignant      |                                                    X                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa-Theca Tumor Malignant,     |                                                                          |             
           Metastatic, Ovary               |                                                    X                     |             
      Hemangioma                           |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
      Polyp Stromal                        |                            X                                             |             
      Sarcoma Stromal                      |          X                                                               |             
                                            __________________________________________________________________________|             
   Vagina                                  |                +                                                         |             
      Leiomyosarcoma                       |                                                                          |             
      Polyp                                |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                      X   |             
      Bronchial, Lymphoma Malignant        |                                                                          |             
          Lymphocytic                      |                                                             X            |             
      Bronchial, Lymphoma Malignant Mixed  |             X                                                            |             
      Iliac, Lymphoma Malignant Lymphocytic|                                                                      X   |             
      Iliac, Lymphoma Malignant Mixed      |             X                                                            |             
      Lumbar, Lymphoma Malignant Mixed     |             X                                                            |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                      X   |             
      Mediastinal, Lymphoma Malignant Mixed|             X                                                            |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                      X   |             
      Renal, Lymphoma Malignant Mixed      |             X                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                             X        X   |             
      Lymphoma Malignant Mixed             |       X     X                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                      X   |             
      Lymphoma Malignant Mixed             |       X     X                                                            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                             X        X   |             
      Lymphoma Malignant Mixed             |       X     X  X                       X                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 3| 3| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 0| 7| 0| 0| 0| 0| 0| 0| 0| 3| 2| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                             X        X   |             
      Lymphoma Malignant Mixed             |             X  X                                                         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |             X                                                            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibrosarcoma    |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                    X                     |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                   X                                                      |             
      Lymphoma Malignant Mixed             |             X                                                            |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +        +                                             |             
      Adenoma                              |                            X                                             |             
      Carcinoma                            |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                             X        X   |             
      Lymphoma Malignant Mixed             |       X     X                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                      X   |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 3| 3| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 0| 7| 0| 0| 0| 0| 0| 0| 0| 3| 2| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                             X        X   |             
      Lymphoma Malignant Mixed             |       X     X  X                       X                                X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 7| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 1| 1| 3| 3| 8| 3| 5| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3| 3| 0| 3| 3| 3| 3| 3|            |
                                           | 4| 7| 1| 1| 1| 6| 1| 5| 1| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 9| 2| 2| 2| 2| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |                               X                                X        X|          4 |
      Hepatocellular Adenoma               |                                           X           X           X     X|          5 |
      Lymphoma Malignant Mixed             |          X                                                        X      |          5 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |          X                                                               |          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Squamous Cell Papilloma              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Spindle Cell, Adenoma                |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Adenoma               |                                                                      X   |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   6                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 7| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 1| 1| 3| 3| 8| 3| 5| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3| 3| 0| 3| 3| 3| 3| 3|            |
                                           | 4| 7| 1| 1| 1| 6| 1| 5| 1| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 9| 2| 2| 2| 2| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cystadenoma                          |                                                                          |          1 |
      Granulosa-Theca Tumor Malignant      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granulosa-Theca Tumor Malignant,     |                                                                          |            |
           Metastatic, Ovary               |                                                                          |          1 |
      Hemangioma                           |                                                                         X|          1 |
      Hemangiosarcoma                      |    X                                                                     |          1 |
      Polyp Stromal                        |                                                                          |          1 |
      Sarcoma Stromal                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                               +                                          |   2        |
      Leiomyosarcoma                       |                               X                                          |          1 |
      Polyp                                |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Axillary, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Bronchial, Lymphoma Malignant        |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Bronchial, Lymphoma Malignant Mixed  |                                                                          |          1 |
      Iliac, Lymphoma Malignant Lymphocytic|                                                                          |          1 |
      Iliac, Lymphoma Malignant Mixed      |                                                                   X      |          2 |
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          1 |
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                   X      |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   7                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 7| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 1| 1| 3| 3| 8| 3| 5| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3| 3| 0| 3| 3| 3| 3| 3|            |
                                           | 4| 7| 1| 1| 1| 6| 1| 5| 1| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 9| 2| 2| 2| 2| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
      Lymphoma Malignant Histiocytic       |                                  X                                       |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                        X                          X      |          4 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |          X                             X                          X      |          7 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  47        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                X                                                         |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                        X                                 |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma                            |                                                                      X   |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteosarcoma                         | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                   +                                                      |   1        |
      Hemangiosarcoma                      |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |          X                          X              X        X            |          5 |
      Alveolar/Bronchiolar Carcinoma       |                X                                                  X      |          2 |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                   X      |          2 |
      Osteosarcoma, Metastatic, Bone       | X                                                                        |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 7| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 1| 1| 3| 3| 8| 3| 5| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3| 3| 0| 3| 3| 3| 3| 3|            |
                                           | 4| 7| 1| 1| 1| 6| 1| 5| 1| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 9| 2| 2| 2| 2| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |          X                                                        X      |          4 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |          X                                                               |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                  X                                       |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |          X                             X                          X      |          8 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   9                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 3| 2| 2| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 0| 0| 3| 4| 7| 0| 0| 0| 1| 0| 1| 1| 1| 1| 2| 3| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    262                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                                                      +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                                      +   |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                   +                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                   +                                                      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Hepatocellular Carcinoma             |       X     X                                                            |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |          X                 X  X     X                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                    +                                +         |             
      Hemangiosarcoma                      |                                                                X         |             
      Lymphoma Malignant Mixed             |          X                    X                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |          X                    X     X                                    |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                          X               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |          X                 X  X                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                      X                                                   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                                        X              X     X            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Lymphoma Malignant Mixed             |                               X                                          |             
      Follicular Cell, Adenoma             |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                               +                                          |             
      Lymphoma Malignant Mixed             |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                                                                      X   |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |          X                    X                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 3| 2| 2| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 0| 0| 3| 4| 7| 0| 0| 0| 1| 0| 1| 1| 1| 1| 2| 3| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    262                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +           +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            | X                                                                        |             
      Deciduoma Benign                     |    X                                                                     |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |          X                                                               |             
      Polyp Stromal                        |                                                                X         |             
      Sarcoma Stromal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +  +                 +                                      +   |             
      Iliac, Lymphoma Malignant Mixed      |          X                                                               |             
      Inguinal, Lymphoma Malignant Mixed   |                               X                                          |             
      Mediastinal, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |             X                                                            |             
      Mediastinal, Lymphoma Malignant Mixed|          X                    X                                          |             
      Renal, Lymphoma Malignant Mixed      |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |          +  M                                                            |             
      Lymphoma Malignant Mixed             |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |          +  +                 +                                      +   |             
      Lymphoma Malignant Mixed             |          X                    X                                      X   |             
                                            __________________________________________________________________________|             
   Spleen                                  |          +              +     +     +        +           +     +     +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |          X                    X     X                                X   |             
                                            __________________________________________________________________________|             
   Thymus                                  |                               +                                          |             
      Lymphoma Malignant Mixed             |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                               X                                          |             
      Lymphoma Malignant Mixed             |                               X                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                               X                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Benign                           |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 3| 2| 2| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 0| 0| 3| 4| 7| 0| 0| 0| 1| 0| 1| 1| 1| 1| 2| 3| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    262                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |             X                                                            |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |       X                                                                 X|             
      Alveolar/Bronchiolar Carcinoma       |             X                                                            |             
      Carcinoma, Metastatic, Uterus        | X                                                                        |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |          X                    X                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  I  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M|             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Lymphoma Malignant Mixed             |          X                    X                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +                                                                        |             
      Carcinoma, Metastatic, Uterus        | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |          X                 X  X     X                                X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 9| 3| 1| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 4| 7| 9| 3| 9| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 1| 7| 1| 1| 4| 1| 1| 1| 1| 1| 2| 2| 0| 1| 7| 1| 2| 0| 2| 2| 2| 2| 2| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    262                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |   1        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosarcoma, Metastatic, Skin       |                                           X                              |          1 |
      Hepatocellular Carcinoma             |                                                                          |          2 |
      Lymphoma Malignant Histiocytic       |                X                                                         |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                               +  +                                       |   5        |
      Hemangiosarcoma                      |                                  X                                       |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Squamous Cell Papilloma              |    X              X                 X                          X         |          5 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|  49        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
      Pars Distalis, Adenoma               |          X                                                  X            |          5 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Follicular Cell, Adenoma             |       X                                                           X      |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  13                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 9| 3| 1| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 4| 7| 9| 3| 9| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 1| 7| 1| 1| 4| 1| 1| 1| 1| 1| 2| 2| 0| 1| 7| 1| 2| 0| 2| 2| 2| 2| 2| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    262                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Cystadenoma                          |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                X                                                         |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +     +  +     +     +  +     +  +  +     +  +|  41        |
      Adenoma                              |                                                    X                     |          1 |
      Carcinoma                            |                                                                      X   |          2 |
      Deciduoma Benign                     |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                X                                                         |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Polyp Stromal                        |                                                                          |          1 |
      Sarcoma Stromal                      |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                              +                           |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                    +  +                  |   6        |
      Iliac, Lymphoma Malignant Mixed      |                                                                          |          1 |
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Mediastinal, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          2 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |   1        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                    +                     |   5        |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |          +                             +     +        +     +     +      |  14        |
      Lymphoma Malignant Lymphocytic       |          X                                                               |          1 |
      Lymphoma Malignant Mixed             |                                                             X     X      |          6 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                          +               |   2        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Carcinoma                            |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  14                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 9| 3| 1| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 4| 7| 9| 3| 9| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 1| 7| 1| 1| 4| 1| 1| 1| 1| 1| 2| 2| 0| 1| 7| 1| 2| 0| 2| 2| 2| 2| 2| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    262                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                           X  X                       X   |          3 |
      Subcutaneous Tissue, Hemangiosarcoma |                      X                                                   |          1 |
      Subcutaneous Tissue, Schwannoma      |                                                                          |            |
          Benign                           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                      M           +        +           +                  |   4        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Fibrosarcoma, Metastatic, Skin       |                                           X                              |          1 |
      Hemangiosarcoma                      |                                  X                                       |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                      X                                                   |          3 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Carcinoma, Metastatic, Uterus        |                                                                          |          1 |
      Fibrosarcoma, Metastatic, Skin       |                                           X                              |          1 |
      Lymphoma Malignant Histiocytic       |                X                                                         |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                      +   |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  43        |
      Adenoma                              |                                  X                                   X   |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosarcoma, Metastatic, Skin       |                                           X                              |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |   1        |
      Carcinoma, Metastatic, Uterus        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  15                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 9| 3| 1| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 4| 7| 9| 3| 9| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 1| 7| 1| 1| 4| 1| 1| 1| 1| 1| 2| 2| 0| 1| 7| 1| 2| 0| 2| 2| 2| 2| 2| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    262                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Histiocytic       |                X                                                         |          1 |
      Lymphoma Malignant Lymphocytic       |          X                                                               |          1 |
      Lymphoma Malignant Mixed             |                                                             X     X      |          7 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  16                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 4| 3| 4| 5| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| 0| 1| 1| 3| 1| 1| 6| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    525                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Leiomyosarcoma, Metastatic, Mesentery|                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyosarcoma, Metastatic, Mesentery|                                                                          |             
      Polyp                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                X                 X                                       |             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
      Lymphoma Malignant Mixed             |    X                    X              X                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                                                        |             
      Hemangiosarcoma                      |                                                                          |             
      Leiomyosarcoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyosarcoma, Metastatic, Mesentery|                                                                          |             
      Lymphoma Malignant Mixed             |    X                                               X                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |    X                          X                    X                     |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyosarcoma, Metastatic, Mesentery|                                                                          |             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
      Squamous Cell Papilloma              | X                                X                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                              +                           |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 4| 3| 4| 5| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| 0| 1| 1| 3| 1| 1| 6| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    525                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |    X                                                                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Adenoma                              |                                              X                 X         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  M  +  +  +  +  M|             
      Pars Distalis, Adenoma               |                                                             X  X     X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                    X                     |             
      Follicular Cell, Adenoma             |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                                     X                             X      |             
      Granulosa-Theca Tumor Malignant      |                                              X                           |             
      Leiomyosarcoma, Metastatic, Mesentery|                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Polyp Stromal                        |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                    X                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Bronchial, Leiomyosarcoma,           |                                                                          |             
          Metastatic, Mesentery            |                                                                          |             
      Iliac, Lymphoma Malignant Mixed      |    X                                                                     |             
      Inguinal, Lymphoma Malignant Mixed   |                                        X                                 |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      | X                                                                        |             
      Mediastinal, Lymphoma Malignant Mixed|                                                    X                     |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |    X                                               X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 4| 3| 4| 5| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| 0| 1| 1| 3| 1| 1| 6| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    525                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |    X                          X        X           X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  I  M  +|             
      Lymphoma Malignant Mixed             |    X                                   X           X                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
      Lymphoma Malignant Mixed             |    X                    X     X        X           X                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  I  I  +  +  M  +|             
      Lymphoma Malignant Mixed             |    X                    X     X                    X                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibroma         |                                                                         X|             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Malignant                        |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                             X           X|             
      Alveolar/Bronchiolar Carcinoma       |                               X                                          |             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                                                                          |             
      Granulosa-Theca Tumor Malignant,     |                                                                          |             
           Metastatic, Ovary               |                                              X                           |             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                         +|             
                                            __________________________________________________________________________|             
   Eye                                     |       +                                                                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +     +                                                            |             
      Adenoma                              |       X     X                                                            |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 4| 3| 4| 5| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| 0| 1| 1| 3| 1| 1| 6| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    525                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Leiomyosarcoma, Metastatic, Mesentery|                                                                          |             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
      Lymphoma Malignant Mixed             |                         X                          X                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
      Lymphoma Malignant Mixed             |                                        X           X                     |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
      Lymphoma Malignant Mixed             |    X                    X     X        X           X                 X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 9| 0| 3| 3| 3| 7| 3| 3| 3| 3| 3| 5| 3| 9| 3| 1| 1| 3| 3| 5| 3| 3| 3| 3| 3|            |
                                           | 2| 8| 1| 1| 1| 1| 1| 1| 1| 2| 2| 6| 2| 3| 2| 1| 1| 2| 2| 5| 2| 2| 2| 2| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    525                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +|  47        |
      Leiomyosarcoma, Metastatic, Mesentery|    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
      Leiomyosarcoma, Metastatic, Mesentery|    X                                                                     |          1 |
      Polyp                                |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
      Carcinoma                            |                                     X                                    |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |                            X                                             |          1 |
      Hepatocellular Adenoma               |                                                             X            |          3 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |             X                    X                                       |          5 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +           +                       +        +                        |   5        |
      Hemangiosarcoma                      |                                        X                                 |          1 |
      Leiomyosarcoma                       |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  48        |
      Leiomyosarcoma, Metastatic, Mesentery|    X                                                                     |          1 |
      Lymphoma Malignant Mixed             |                                  X                                       |          3 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leiomyosarcoma, Metastatic, Mesentery|    X                                                                     |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Squamous Cell Papilloma              |                                        X              X                  |          4 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |       +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  21                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 9| 0| 3| 3| 3| 7| 3| 3| 3| 3| 3| 5| 3| 9| 3| 1| 1| 3| 3| 5| 3| 3| 3| 3| 3|            |
                                           | 2| 8| 1| 1| 1| 1| 1| 1| 1| 2| 2| 6| 2| 3| 2| 1| 1| 2| 2| 5| 2| 2| 2| 2| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    525                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pheochromocytoma Malignant           | X                                                                        |          1 |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  47        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  I  +  +  +  +  +  +  +|  43        |
      Pars Distalis, Adenoma               |       X                    X  X           X                              |          7 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                            +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  M  +  +  +  +|  46        |
      Cystadenoma                          |                               X                          X               |          4 |
      Granulosa-Theca Tumor Malignant      |                                                                          |          1 |
      Leiomyosarcoma, Metastatic, Mesentery|    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                        X                                 |          1 |
      Polyp Stromal                        |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                     +                                    |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                  X                                       |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Bronchial, Leiomyosarcoma,           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  22                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 9| 0| 3| 3| 3| 7| 3| 3| 3| 3| 3| 5| 3| 9| 3| 1| 1| 3| 3| 5| 3| 3| 3| 3| 3|            |
                                           | 2| 8| 1| 1| 1| 1| 1| 1| 1| 2| 2| 6| 2| 3| 2| 1| 1| 2| 2| 5| 2| 2| 2| 2| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    525                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Metastatic, Mesentery            |    X                                                                     |          1 |
      Iliac, Lymphoma Malignant Mixed      |                                                                          |          1 |
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                  X                                       |          2 |
      Pancreatic, Lymphoma Malignant Mixed |                                  X                                       |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +|  45        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  M|  43        |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |             X                    X                                       |          7 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +|  44        |
      Lymphoma Malignant Mixed             |                                                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma                            |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Schwannoma      |                                                                          |            |
          Malignant                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                   X      |          3 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                                                X         |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  23                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 9| 0| 3| 3| 3| 7| 3| 3| 3| 3| 3| 5| 3| 9| 3| 1| 1| 3| 3| 5| 3| 3| 3| 3| 3|            |
                                           | 2| 8| 1| 1| 1| 1| 1| 1| 1| 2| 2| 6| 2| 3| 2| 1| 1| 2| 2| 5| 2| 2| 2| 2| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    525                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Granulosa-Theca Tumor Malignant,     |                                                                          |            |
           Metastatic, Ovary               |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                            +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                +         |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                        +                       +         |   4        |
      Adenoma                              |                                        X                                 |          3 |
      Carcinoma                            |                                                                X         |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leiomyosarcoma, Metastatic, Mesentery|    X                                                                     |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |             X                    X                                       |          8 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  24                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 7| 3| 4| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 7| 7| 2| 2| 2| 8| 4| 2| 0| 2| 3| 2| 2| 2| 7| 8| 2| 2| 2| 2| 2| 2| 2| 2| 1|             
                                           | 3| 3| 9| 9| 9| 5| 1| 9| 3| 9| 3| 9| 9| 9| 8| 8| 9| 9| 9| 9| 9| 1| 9| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  M  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             | X  X  X        X        X     X  X                          X  X         |             
      Hepatocellular Adenoma               |                      X     X           X        X  X  X           X      |             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
      Lymphoma Malignant Mixed             |                            X                                             |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                +         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                           X                              |             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
      Squamous Cell Papilloma              | X                    X           X     X                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                            +        +              +  +     +     +     +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |             X                                   X                        |             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
      Pheochromocytoma Malignant           |                                              X                           |             
      Pheochromocytoma Benign              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 7| 3| 4| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 7| 7| 2| 2| 2| 8| 4| 2| 0| 2| 3| 2| 2| 2| 7| 8| 2| 2| 2| 2| 2| 2| 2| 2| 1|             
                                           | 3| 3| 9| 9| 9| 5| 1| 9| 3| 9| 3| 9| 9| 9| 8| 8| 9| 9| 9| 9| 9| 1| 9| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  M  +  +  +  M  +  M  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
      Follicular Cell, Adenoma             |                                                 X                        |             
      Follicular Cell, Carcinoma           |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                   +                                                      |             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
                                            __________________________________________________________________________|             
   Penis                                   |             +                                                            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +  +        +  +  +     +  +  +        +  +     +               |             
                                            __________________________________________________________________________|             
   Prostate                                | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                   +        +                       +                     |             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Adenoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |          +        +  +     +                       +  +           +      |             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
      Lymphoma Malignant Mixed             |                            X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hemangiosarcoma            |          X                                                               |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                   X                                                      |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                   X                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 7| 3| 4| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 7| 7| 2| 2| 2| 8| 4| 2| 0| 2| 3| 2| 2| 2| 7| 8| 2| 2| 2| 2| 2| 2| 2| 2| 1|             
                                           | 3| 3| 9| 9| 9| 5| 1| 9| 3| 9| 3| 9| 9| 9| 8| 8| 9| 9| 9| 9| 9| 1| 9| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |          X                                                               |             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
      Lymphoma Malignant Mixed             |                            X                                             |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |          X              X     X           X                       X      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                   +                                                      |             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |          X              X              X              X           X      |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |       X                                                                  |             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +  +           +                                       |             
      Adenoma                              |                      X           X                                       |             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 7| 3| 4| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 7| 7| 2| 2| 2| 8| 4| 2| 0| 2| 3| 2| 2| 2| 7| 8| 2| 2| 2| 2| 2| 2| 2| 2| 1|             
                                           | 3| 3| 9| 9| 9| 5| 1| 9| 3| 9| 3| 9| 9| 9| 8| 8| 9| 9| 9| 9| 9| 1| 9| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
      Lymphoma Malignant Mixed             |                            X                                             |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 5| 7| 5| 7| 7| 7| 5|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 4| 2| 8| 2| 2| 2| 8|            |
                                           | 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 9| 9| 5| 9| 9| 0| 9| 2| 9| 9| 9| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  I  M|  46        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  I  +  M  +  M  +  +  +  M|  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                 X     X                  |          2 |
      Hepatocellular Carcinoma             |          X                             X        X           X  X  X  X   |         16 |
      Hepatocellular Adenoma               |                                                                         X|          8 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +                                   +         |   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Squamous Cell Papilloma              |                         X           X     X                              |          7 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |       +                                                     +  +         |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Adenoma                              |                               X                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  29                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 5| 7| 5| 7| 7| 7| 5|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 4| 2| 8| 2| 2| 2| 8|            |
                                           | 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 9| 9| 5| 9| 9| 0| 9| 2| 9| 9| 9| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                                      X   |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +        +     +     +              +                          +     +|  18        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                +                    +        +                    +  +   |   8        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Interstitial Cell, Adenoma           |                                                    X                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   7        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Hemangiosarcoma            |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  30                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 5| 7| 5| 7| 7| 7| 5|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 4| 2| 8| 2| 2| 2| 8|            |
                                           | 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 9| 9| 5| 9| 9| 0| 9| 2| 9| 9| 9| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Undifferentiated Cell Type       |                                                    X                     |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  45        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |    X                                                                     |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +|  42        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Fibroma         |                                                    X                     |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |             X                    X  X           X                        |          9 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |       X        X                    X              X                 X   |         10 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  31                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 5| 7| 5| 7| 7| 7| 5|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 4| 2| 8| 2| 2| 2| 8|            |
                                           | 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 9| 9| 5| 9| 9| 0| 9| 2| 9| 9| 9| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Liver                           |                                                                      X   |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +                 +              +                                 |   3        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |       +  +  +           +              +                                +|   9        |
      Adenoma                              |       X  X  X           X              X                                X|          8 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                              +                           |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |    X                                                                     |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                    X                     |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  32                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 1| 3| 7| 7| 7| 7| 7| 7| 7| 7| 3| 4| 6| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 4| 0| 1| 3| 5|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 1| 0| 0| 0| 0| 0| 0| 0| 0| 4| 1| 3| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    262                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  M  +  +  +  A  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  M  +  +  +|             
      Lymphoma Malignant Mixed             |             X                                                            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                 X                        |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                X  X                                         X           X|             
      Lymphoma Malignant Histiocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |             X  X                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                +         |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                              +     +     +               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |          X                                                           X   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Malignant           | X                                                                        |             
      Pheochromocytoma Benign              |                      X                                                   |             
      Bilateral, Pheochromocytoma Benign   |                                     X                                    |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |       X                                      X                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 1| 3| 7| 7| 7| 7| 7| 7| 7| 7| 3| 4| 6| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 4| 0| 1| 3| 5|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 1| 0| 0| 0| 0| 0| 0| 0| 0| 4| 1| 3| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    262                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                  M                                       |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +     +     +     +  +        +     +     +     +        +     +   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                               +  +                                       |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |          +                                                               |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                   X      |             
      Lymphoma Malignant Mixed             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  M  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  I  M  M  M  M  M  M  M  M  M  +  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basosquamous Tumor Benign            |                                                    X                     |             
      Subcutaneous Tissue, Fibroma         |                   X                                                      |             
      Subcutaneous Tissue, Fibrosarcoma    |          X              X                                         X      |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Malignant                        |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
      Schwannoma Malignant                 |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         | X                          X              X     X                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 1| 3| 7| 7| 7| 7| 7| 7| 7| 7| 3| 4| 6| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 4| 0| 1| 3| 5|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 1| 0| 0| 0| 0| 0| 0| 0| 0| 4| 1| 3| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    262                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Adenoma                              |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                   X      |             
      Lymphoma Malignant Mixed             |             X                                   X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 7| 5| 3| 4| 7| 7| 7| 5| 7| 7| 6| 5| 1| 7| 1| 1| 7| 2| 4| 7| 5| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 9| 1| 3| 3| 3| 8| 3| 3| 0| 1| 5| 3| 4| 8| 3| 7| 3| 3| 8| 3|            |
                                           | 0| 0| 0| 0| 2| 1| 2| 0| 0| 0| 4| 0| 0| 5| 9| 1| 0| 6| 7| 0| 0| 6| 0| 4| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    262                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  M  M  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  A  +  +  M  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  M  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatocellular Carcinoma             |                               X                                      X   |          2 |
      Hepatocellular Adenoma               |                         X              X                                 |          6 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                            +                        |   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Squamous Cell Papilloma              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |       +                          +                                       |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                                   X      |          3 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |                                     X           X                       X|          4 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  36                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 7| 5| 3| 4| 7| 7| 7| 5| 7| 7| 6| 5| 1| 7| 1| 1| 7| 2| 4| 7| 5| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 9| 1| 3| 3| 3| 8| 3| 3| 0| 1| 5| 3| 4| 8| 3| 7| 3| 3| 8| 3|            |
                                           | 0| 0| 0| 0| 2| 1| 2| 0| 0| 0| 4| 0| 0| 5| 9| 1| 0| 6| 7| 0| 0| 6| 0| 4| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    262                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Adenoma             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                           +                              |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +        M        +  +  +  +  +  +                    +               |  20        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                     +        +                 +         |   5        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                            +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  46        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  M  +  +  +  +  +  +  M  +     +  +  +  +  +  +  M  +  +  +  +  +|  39        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M|   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basosquamous Tumor Benign            |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                            X           X        X                        |          6 |
      Subcutaneous Tissue, Schwannoma      |                                                                          |            |
          Malignant                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  37                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 7| 5| 3| 4| 7| 7| 7| 5| 7| 7| 6| 5| 1| 7| 1| 1| 7| 2| 4| 7| 5| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 9| 1| 3| 3| 3| 8| 3| 3| 0| 1| 5| 3| 4| 8| 3| 7| 3| 3| 8| 3|            |
                                           | 0| 0| 0| 0| 2| 1| 2| 0| 0| 0| 4| 0| 0| 5| 9| 1| 0| 6| 7| 0| 0| 6| 0| 4| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    262                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +                                                              +  +      |   4        |
      Schwannoma Malignant                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |       X                          X                    X           X     X|          9 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                     M                                    |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Urethra                                 | +                          +                       +           +         |   4        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  38                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 6| 6| 6| 3| 4| 4| 7| 5| 1| 1| 6| 7| 5| 1| 4| 5| 7| 7| 7| 5| 0| 6| 1|             
                             DAY ON TEST   | 9| 0| 9| 5| 5| 8| 3| 4| 2| 6| 8| 8| 0| 2| 1| 9| 2| 4| 2| 2| 2| 6| 6| 5| 5|             
                                           | 3| 3| 0| 7| 2| 5| 1| 5| 9| 8| 5| 8| 1| 9| 2| 2| 7| 5| 9| 9| 9| 8| 7| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    525                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                            X        X              X  X        X     X   |             
      Hepatocellular Adenoma               |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                 X                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |    X                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |          +  +                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Spindle Cell, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  I  M  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Follicular Cell, Adenoma             |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 6| 6| 6| 3| 4| 4| 7| 5| 1| 1| 6| 7| 5| 1| 4| 5| 7| 7| 7| 5| 0| 6| 1|             
                             DAY ON TEST   | 9| 0| 9| 5| 5| 8| 3| 4| 2| 6| 8| 8| 0| 2| 1| 9| 2| 4| 2| 2| 2| 6| 6| 5| 5|             
                                           | 3| 3| 0| 7| 2| 5| 1| 5| 9| 8| 5| 8| 1| 9| 2| 2| 7| 5| 9| 9| 9| 8| 7| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    525                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |          +                                                           +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +        +  +              +  +  +     +  +           +     +        +   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |       X                                                                  |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                   +     +           +           +     +              +  A|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Adenoma           |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  M|             
      Lymphoma Malignant Histiocytic       |                                                 X                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  M  +  M  M  +  +  +  M  +  M  +  +  M  +  +  I  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                      X   |             
      Carcinoma                            |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |       X     X                                      X                     |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                         X                                                |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Malignant                        |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                            X        X                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 6| 6| 6| 3| 4| 4| 7| 5| 1| 1| 6| 7| 5| 1| 4| 5| 7| 7| 7| 5| 0| 6| 1|             
                             DAY ON TEST   | 9| 0| 9| 5| 5| 8| 3| 4| 2| 6| 8| 8| 0| 2| 1| 9| 2| 4| 2| 2| 2| 6| 6| 5| 5|             
                                           | 3| 3| 0| 7| 2| 5| 1| 5| 9| 8| 5| 8| 1| 9| 2| 2| 7| 5| 9| 9| 9| 8| 7| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    525                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                X         |             
      Lymphoma Malignant Histiocytic       |                                                 X                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                   +                                                      |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Urethra                                 |                               +                    +                    +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 5| 6| 5| 5| 1| 1| 1| 7| 5| 1| 3| 7| 7| 5| 7| 5| 6| 7| 7| 1| 1| 1| 1| 7|            |
                             DAY ON TEST   | 8| 8| 4| 8| 6| 0| 1| 1| 2| 8| 1| 2| 2| 2| 1| 2| 9| 5| 2| 3| 6| 6| 7| 7| 3|            |
                                           | 1| 5| 0| 3| 8| 8| 9| 9| 9| 5| 9| 9| 9| 9| 4| 9| 7| 6| 9| 0| 9| 9| 0| 1| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    525                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  A  +  +  M  M  M  +  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  M  +  +  +  +  A  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  A  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |                                           X        X                     |          8 |
      Hepatocellular Adenoma               |                         X                                                |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +           +              +        +                       +           +|   7        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                   +  +                                                   |   2        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                    +                     |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Spindle Cell, Adenoma                |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pheochromocytoma Benign              |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +  M  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Follicular Cell, Adenoma             |                                                    X                     |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  42                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 5| 6| 5| 5| 1| 1| 1| 7| 5| 1| 3| 7| 7| 5| 7| 5| 6| 7| 7| 1| 1| 1| 1| 7|            |
                             DAY ON TEST   | 8| 8| 4| 8| 6| 0| 1| 1| 2| 8| 1| 2| 2| 2| 1| 2| 9| 5| 2| 3| 6| 6| 7| 7| 3|            |
                                           | 1| 5| 0| 3| 8| 8| 9| 9| 9| 5| 9| 9| 9| 9| 4| 9| 7| 6| 9| 0| 9| 9| 0| 1| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    525                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                        +                                 |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +     +  +                          +                                +|  17        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                              +           +              +|   9        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Interstitial Cell, Adenoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  M  +  +  M  A  +  +  +  +  +  +  +  +  M  +  +  +  +|  41        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  M  +  +  I  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  38        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                           X                              |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |             X                                X  X                        |          6 |
      Subcutaneous Tissue, Hemangiosarcoma |                                                          X               |          1 |
      Subcutaneous Tissue, Lipoma          |                                                                          |          1 |
      Subcutaneous Tissue, Schwannoma      |                                                                          |            |
          Malignant                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  43                                                               
NTP Experiment-Test: 05002-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/09/97  
Route: GAVAGE                                                                                                     Time: 12:54:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 5| 6| 5| 5| 1| 1| 1| 7| 5| 1| 3| 7| 7| 5| 7| 5| 6| 7| 7| 1| 1| 1| 1| 7|            |
                             DAY ON TEST   | 8| 8| 4| 8| 6| 0| 1| 1| 2| 8| 1| 2| 2| 2| 1| 2| 9| 5| 2| 3| 6| 6| 7| 7| 3|            |
                                           | 1| 5| 0| 3| 8| 8| 9| 9| 9| 5| 9| 9| 9| 9| 4| 9| 7| 6| 9| 0| 9| 9| 0| 1| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    525                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                            +                                             |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |          +                                                               |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |    X                       X           X           X                     |          6 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |          +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  44                                                               
                                  ------------------------------------------------------------                                      
                                  ----------              END OF REPORT             ----------                                      
                                  ------------------------------------------------------------                                      
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.