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TDMS Study 05002-05 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                        GAMMA-BUTYROLACTONE


NTP Experiment-Test: 05002-05                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/02/94
Route: GAVAGE                                                                                                     Time: 17:53:00




       Facility:  Southern Research Institute

       Chemical CAS #:  96-48-0

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05002-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 17:53:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      225.         450.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          19           16           14                                                  
    Dead                                               3            7            6                                                  
    Dosing Accident                                                              2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           26           28                                                  
    Dead                                                            1                                                               
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (48)         (18)         (46)                                                
   Intestine Large, Colon                             (48)         (20)         (49)                                                
   Intestine Large, Rectum                            (48)         (20)         (43)                                                
      Mixed Tumor Malignant, Metastatic, Mammary                                                                                    
          Gland                                                     1 (5%)                                                          
   Intestine Small, Ileum                             (47)         (20)         (45)                                                
   Intestine Small, Jejunum                           (47)         (20)         (47)                                                
   Liver                                              (50)         (50)         (50)                                                
      Mixed Tumor Malignant, Metastatic, Mammary                                                                                    
          Gland                                                     1 (2%)                                                          
   Mesentery                                          (5)          (3)          (4)                                                 
   Pancreas                                           (49)         (24)         (50)                                                
      Acinar Cell, Adenoma                             2 (4%)                                                                       
   Pharynx                                                         (2)                                                              
      Palate, Squamous Cell Carcinoma                               1 (50%)                                                         
      Palate, Squamous Cell Papilloma                               1 (50%)                                                         
   Salivary Glands                                    (50)         (24)         (50)                                                
      Carcinoma, Metastatic                                                      1 (2%)                                             
   Stomach                                            (49)         (24)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (25)         (50)                                                
      Fibrosarcoma, Metastatic, Lung                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05002-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 17:53:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      225.         450.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (25)         (50)                                                
      Adenoma                                          1 (2%)                    2 (4%)                                             
   Adrenal Gland, Medulla                             (50)         (25)         (49)                                                
      Pheochromocytoma Malignant                                    1 (4%)                                                          
      Pheochromocytoma Benign                          1 (2%)                    4 (8%)                                             
   Islets, Pancreatic                                 (49)         (24)         (50)                                                
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                                                  1 (2%)                                             
   Parathyroid Gland                                  (48)         (23)         (47)                                                
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
   Pituitary Gland                                    (49)         (37)         (48)                                                
      Pars Distalis, Adenoma                          22 (45%)     24 (65%)     16 (33%)                                            
   Thyroid Gland                                      (50)         (27)         (50)                                                
      C-Cell, Adenoma                                  7 (14%)      2 (7%)       3 (6%)                                             
      C-Cell, Carcinoma                                1 (2%)       1 (4%)       1 (2%)                                             
      Follicular Cell, Carcinoma                       1 (2%)       1 (4%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (22)         (46)                                                
      Adenoma                                          5 (10%)      4 (18%)      5 (11%)                                            
      Carcinoma                                                                  1 (2%)                                             
      Bilateral, Adenoma                               1 (2%)       1 (5%)                                                          
   Ovary                                              (50)         (24)         (50)                                                
   Uterus                                             (50)         (32)         (50)                                                
      Adenocarcinoma                                                1 (3%)                                                          
      Adenoma                                                                    1 (2%)                                             
      Hemangiosarcoma                                                            1 (2%)                                             
      Polyp Stromal                                   10 (20%)      7 (22%)     12 (24%)                                            
      Polyp Stromal, Multiple                                       2 (6%)       1 (2%)                                             
      Sarcoma Stromal                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (2)                       (4)                                                 
   Bone Marrow                                        (49)         (24)         (50)                                                
   Lymph Node                                         (50)         (26)         (50)                                                
      Axillary, Mixed Tumor Malignant, Metastatic,                                                                                  
           Mammary Gland                                            1 (4%)                                                          
                                                             Page   3                                                               
NTP Experiment-Test: 05002-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 17:53:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      225.         450.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Lymph Node, Mandibular                             (49)         (23)         (50)                                                
      Carcinoma, Metastatic                                                      1 (2%)                                             
   Lymph Node, Mesenteric                             (49)         (24)         (49)                                                
   Spleen                                             (48)         (49)         (50)                                                
      Sarcoma                                                       1 (2%)                                                          
   Thymus                                             (48)         (21)         (47)                                                
      Fibrosarcoma, Metastatic, Lung                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)                                                
      Adenocarcinoma                                   4 (8%)                                                                       
      Adenoma                                                                    1 (2%)                                             
      Fibroadenoma                                    16 (32%)     10 (20%)      5 (10%)                                            
      Fibroadenoma, Multiple                           6 (12%)      4 (8%)       1 (2%)                                             
      Mixed Tumor Malignant                                         1 (2%)                                                          
   Skin                                               (50)         (28)         (50)                                                
      Lip, Squamous Cell Papilloma                     1 (2%)                                                                       
      Subcutaneous Tissue, Carcinoma, Metastatic                                 1 (2%)                                             
      Subcutaneous Tissue, Fibroma                                  1 (4%)                                                          
      Subcutaneous Tissue, Fibroma, Multiple           1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                             1 (4%)       1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (2%)                                             
      Subcutaneous Tissue, Myxosarcoma                 1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                                  1 (4%)       1 (2%)                                             
      Subcutaneous Tissue, Squamous Cell Carcinoma,                                                                                 
           Multiple                                                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (28)         (50)                                                
      Vertebra, Osteosarcoma                                        1 (4%)                                                          
   Skeletal Muscle                                    (2)                       (1)                                                 
      Hindlimb, Hemangiosarcoma, Extension                                       1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (24)         (50)                                                
      Astrocytoma Malignant                                                      1 (2%)                                             
      Meninges, Carcinoma, Metastatic, Zymbal's                                                                                     
          Gland                                                     1 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05002-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 17:53:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      225.         450.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (30)         (50)                                                
      Alveolar/Bronchiolar Adenoma                                  1 (3%)       2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Carcinoma, Metastatic                                                      1 (2%)                                             
      Mixed Tumor Malignant, Metastatic, Mammary                                                                                    
          Gland                                                     1 (3%)                                                          
      Mediastinum, Fibrosarcoma                        1 (2%)                                                                       
      Mediastinum, Mixed Tumor Malignant,                                                                                           
          Metastatic, Mammary Gland                                 1 (3%)                                                          
      Mediastinum, Squamous Cell Carcinoma             1 (2%)                                                                       
   Trachea                                            (50)         (24)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (2)          (1)                                                 
      Carcinoma                                                     2 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (24)         (49)                                                
   Urinary Bladder                                    (50)         (24)         (50)                                                
      Transitional Epithelium, Papilloma, Multiple     1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            13 (26%)      9 (18%)     11 (22%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05002-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 17:53:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      225.         450.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            46          46          41                                                   
     Total Primary Neoplasms                           99          78          77                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 38          42          33                                                   
     Total Benign Neoplasms                            75          57          53                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          19          19                                                   
     Total Malignant Neoplasms                         24          21          24                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           2           1                                                   
     Total Metastatic Neoplasm                          3           6           4                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05002-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 17:53:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      112.         225.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               6            7            3                                                  
    Moribund                                          19           13           12                                                  
    Dosing Accident                                    1            3            3                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                24           27           32                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (48)         (17)         (49)                                                
   Intestine Large, Colon                             (47)         (21)         (50)                                                
      Polyp Adenomatous                                             1 (5%)                                                          
   Intestine Large, Rectum                            (47)         (19)         (49)                                                
   Intestine Small, Ileum                             (46)         (18)         (49)                                                
   Intestine Small, Jejunum                           (46)         (17)         (50)                                                
      Adenocarcinoma                                   1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)                                                
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                                           1 (2%)                                             
      Hepatocellular Carcinoma                                      1 (2%)                                                          
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (2%)                                                                       
   Mesentery                                          (11)         (10)         (19)                                                
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                                           1 (5%)                                             
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (9%)                                                                       
   Pancreas                                           (50)         (22)         (50)                                                
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                                           1 (2%)                                             
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (2%)                                                                       
      Acinar Cell, Adenoma                             4 (8%)                    4 (8%)                                             
      Acinar Cell, Adenoma, Multiple                   3 (6%)                    1 (2%)                                             
   Salivary Glands                                    (49)         (23)         (50)                                                
      Schwannoma Malignant                                          1 (4%)                                                          
   Stomach                                            (50)         (29)         (50)                                                
      Forestomach, Squamous Cell Papilloma             1 (2%)                    1 (2%)                                             
   Tongue                                             (3)          (4)                                                              
      Squamous Cell Papilloma                                       1 (25%)                                                         
____________________________________________________________________________________________________________________________________
                                                             Page   7                                                               
NTP Experiment-Test: 05002-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 17:53:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      112.         225.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (25)         (50)                                                
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                                           1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (48)         (24)         (49)                                                
      Adenoma                                          1 (2%)                    1 (2%)                                             
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                                           1 (2%)                                             
   Adrenal Gland, Medulla                             (48)         (23)         (49)                                                
      Pheochromocytoma Malignant                                    1 (4%)       5 (10%)                                            
      Pheochromocytoma Benign                         10 (21%)      6 (26%)      7 (14%)                                            
      Bilateral, Pheochromocytoma Benign               5 (10%)      4 (17%)      7 (14%)                                            
   Islets, Pancreatic                                 (49)         (22)         (50)                                                
      Adenoma                                          3 (6%)                    2 (4%)                                             
      Adenoma, Multiple                                                          1 (2%)                                             
      Carcinoma                                        2 (4%)       1 (5%)                                                          
   Parathyroid Gland                                  (46)         (22)         (48)                                                
      Adenoma                                                                    1 (2%)                                             
   Pituitary Gland                                    (48)         (28)         (49)                                                
      Pars Distalis, Adenoma                          11 (23%)     11 (39%)     16 (33%)                                            
      Pars Distalis, Carcinoma                         1 (2%)       1 (4%)                                                          
   Thyroid Gland                                      (50)         (25)         (50)                                                
      Bilateral, C-Cell, Adenoma                       1 (2%)                                                                       
      C-Cell, Adenoma                                  6 (12%)      1 (4%)       5 (10%)                                            
      C-Cell, Carcinoma                                4 (8%)       1 (4%)       2 (4%)                                             
      Follicular Cell, Adenoma                         1 (2%)                                                                       
      Follicular Cell, Carcinoma                       1 (2%)       1 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (23)         (50)                                                
   Preputial Gland                                    (48)         (24)         (50)                                                
      Adenoma                                          6 (13%)      1 (4%)       2 (4%)                                             
      Carcinoma                                        1 (2%)       3 (13%)      3 (6%)                                             
      Bilateral, Carcinoma                                          1 (4%)                                                          
   Prostate                                           (49)         (24)         (49)                                                
                                                             Page   8                                                               
NTP Experiment-Test: 05002-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 17:53:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      112.         225.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
   Seminal Vesicle                                    (50)         (25)         (50)                                                
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                                           1 (2%)                                             
   Testes                                             (50)         (50)         (50)                                                
      Bilateral, Interstitial Cell, Adenoma           37 (74%)     36 (72%)     35 (70%)                                            
      Interstitial Cell, Adenoma                       7 (14%)     10 (20%)      9 (18%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (2)          (2)                                                              
   Bone Marrow                                        (50)         (23)         (50)                                                
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                                           1 (2%)                                             
   Lymph Node                                         (50)         (25)         (50)                                                
      Inguinal, Fibrous Histiocytoma, Metastatic,                                                                                   
           Uncertain Primary Site                                                1 (2%)                                             
      Mediastinal, Fibrous Histiocytoma,                                                                                            
          Metastatic, Uncertain Primary Site                                     1 (2%)                                             
   Lymph Node, Mandibular                             (48)         (21)         (49)                                                
   Lymph Node, Mesenteric                             (48)         (23)         (50)                                                
   Spleen                                             (50)         (45)         (50)                                                
      Fibrosarcoma                                     1 (2%)                                                                       
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                                           1 (2%)                                             
      Hemangiosarcoma                                  1 (2%)                                                                       
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (2%)                                                                       
   Thymus                                             (43)         (20)         (49)                                                
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                                           1 (2%)                                             
      Thymoma Benign                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (44)         (23)         (48)                                                
      Adenocarcinoma                                                1 (4%)                                                          
      Fibroadenoma                                     4 (9%)       1 (4%)       3 (6%)                                             
   Skin                                               (50)         (37)         (50)                                                
      Basal Cell Adenoma                                            4 (11%)                                                         
      Basal Cell Carcinoma                                                       1 (2%)                                             
      Keratoacanthoma                                  1 (2%)       4 (11%)      5 (10%)                                            
      Keratoacanthoma, Multiple                                                  1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     3 (6%)       4 (11%)      4 (8%)                                             
      Subcutaneous Tissue, Fibroma, Multiple                        2 (5%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                4 (8%)                                                                       
                                                             Page   9                                                               
NTP Experiment-Test: 05002-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 17:53:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      112.         225.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Lipoma                                                2 (4%)                                             
      Subcutaneous Tissue, Myxosarcoma                              1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (23)         (50)                                                
      Cranium, Carcinoma, Metastatic, Zymbal's                                                                                      
          Gland                                        1 (2%)                                                                       
   Skeletal Muscle                                    (1)          (1)          (3)                                                 
      Fibroma                                                       1 (100%)                                                        
      Abdominal, Osteosarcoma, Metastatic,                                                                                          
          Uncertain Primary Site                       1 (100%)                                                                     
      Back, Fibrous Histiocytoma, Metastatic,                                                                                       
          Uncertain Primary Site                                                 1 (33%)                                            
      Diaphragm, Osteosarcoma, Metastatic,                                                                                          
          Uncertain Primary Site                       1 (100%)                                                                     
      Neck, Carcinoma, Extension, Metastatic,                                                                                       
          Thyroid Gland                                                          1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (24)         (50)                                                
      Astrocytoma Malignant                                         1 (4%)                                                          
      Meningioma Malignant                             1 (2%)                                                                       
      Meninges, Carcinoma, Metastatic, Zymbal's                                                                                     
          Gland                                        1 (2%)                                                                       
      Nerve, Carcinoma, Metastatic, Zymbal's Gland     1 (2%)                                                                       
   Spinal Cord                                        (2)                       (1)                                                 
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                                           1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (29)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     2 (4%)       1 (3%)       3 (6%)                                             
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                             
      Carcinoma, Multiple, Metastatic, Thyroid                                                                                      
          Gland                                                                  1 (2%)                                             
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                                           1 (2%)                                             
      Osteosarcoma, Metastatic                                      1 (3%)                                                          
      Artery, Pheochromocytoma Malignant,                                                                                           
          Metastatic, Adrenal Gland                                              1 (2%)                                             
      Mediastinum, Osteosarcoma, Metastatic,                                                                                        
                                                             Page  10                                                               
NTP Experiment-Test: 05002-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 17:53:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      112.         225.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
          Uncertain Primary Site                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (2)                       (2)                                                 
      Schwannoma Malignant                                                       1 (50%)                                            
   Zymbal's Gland                                     (1)                       (1)                                                 
      Carcinoma                                        1 (100%)                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (23)         (50)                                                
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                                           1 (2%)                                             
      Lipoma                                                        1 (4%)                                                          
      Transitional Epithelium, Carcinoma               1 (2%)       1 (4%)                                                          
   Urinary Bladder                                    (48)         (22)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            16 (32%)     15 (30%)      9 (18%)                                            
      Mesothelioma Malignant                                        1 (2%)       4 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  11                                                               
NTP Experiment-Test: 05002-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 17:53:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      112.         225.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          49          50                                                   
     Total Primary Neoplasms                          141         120         138                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 46          48          50                                                   
     Total Benign Neoplasms                           106          89         111                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              29          29          22                                                   
     Total Malignant Neoplasms                         35          31          27                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           1           3                                                   
     Total Metastatic Neoplasm                         10           1          18                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  12                                                               
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