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TDMS Study 05002-05 Pathology Tables

NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97
Route: GAVAGE                                                                                                     Time: 07:03:43




       Facility:  Southern Research Institute

       Chemical CAS #:  96-48-0

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 6| 7| 7|             
                             DAY ON TEST   | 1| 9| 3| 3| 3| 5| 2| 3| 3| 3| 6| 3| 3| 3| 3| 6| 6| 0| 3| 3| 5| 7| 6| 3| 3|             
                                           | 6| 8| 0| 0| 0| 1| 6| 0| 0| 0| 3| 1| 1| 1| 1| 6| 7| 2| 1| 1| 6| 4| 8| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Inflammation, Chronic        | 3                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lipocyte      |                                                                          |             
      Parasite Metazoan                    |                            2     2                             2         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2                                                                  |             
      Basophilic Focus                     |                                                                          |             
      Basophilic Focus, Multiple           |       2  2  1        2  2  2  2  2  2  2  2           2  2  1  2  2  2  1|             
      Eosinophilic Focus                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                2         |             
      Hepatodiaphragmatic Nodule           |       3              2                                                   |             
      Hyperplasia, Nodular                 |                                                    4                     |             
      Inflammation, Granulomatous, Multiple|                            2                             1               |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Focal                      |       2                                                                  |             
      Vacuolization Cytoplasmic            |                2                             3                           |             
      Bile Duct, Hyperplasia               |          2                 2  1  2           1     2                     |             
      Centrilobular, Necrosis, Multiple    |                4                                                         |             
      Serosa, Hemorrhage                   |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                                  +                     |             
      Fat, Inflammation, Chronic           | 4                                                                        |             
      Fat, Necrosis, Focal                 | 3                                                                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinar Cell, Atrophy                 |             2                                                           2|             
      Acinar Cell, Hyperplasia             |                                     3                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Edema                   |                                                                          |             
      Forestomach, Inflammation, Chronic   |                                                                          |             
      Forestomach, Ulcer                   |                2                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     A  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    2  2     2     3  2  2  2  2  2  2  2  2           2     2     2  2  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 6| 7| 7|             
                             DAY ON TEST   | 1| 9| 3| 3| 3| 5| 2| 3| 3| 3| 6| 3| 3| 3| 3| 6| 6| 0| 3| 3| 5| 7| 6| 3| 3|             
                                           | 6| 8| 0| 0| 0| 1| 6| 0| 0| 0| 3| 1| 1| 1| 1| 6| 7| 2| 1| 1| 6| 4| 8| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                     2                                2   |             
      Angiectasis                          |    4                                                                     |             
      Degeneration, Cystic                 |    2                                                     2               |             
      Hematopoietic Cell Proliferation     |          2                                                               |             
      Hypertrophy, Focal                   |                                     2                                    |             
      Vacuolization Cytoplasmic            |       2  2                                                              1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                              2                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                      1   |             
      Cyst, Multiple                       |                                              1              1            |             
      Pars Distalis, Angiectasis           |                         3                                                |             
      Pars Distalis, Cyst                  |    2     1              2                          2                    2|             
      Pars Distalis, Cyst, Multiple        | 2                    2     1     3     2        3              2         |             
      Pars Distalis, Hyperplasia, Focal    |          3                       2              4           2            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |       2                                                           2      |             
      C-Cell, Hyperplasia                  |       2  3                          2                          2         |             
      Follicle, Cyst                       |                                     2                                    |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                              3                           |             
      Inflammation, Suppurative            |                      2                       4              3            |             
      Necrosis                             |                                                                          |             
      Duct, Cyst                           |                         3           3              3                 3  3|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                3                       3                                 |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Decidual Reaction                    |             2                                                            |             
      Dilatation                           |             2                                            2  3            |             
      Inflammation, Suppurative            |             2                                                            |             
      Cervix, Cyst                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 6| 7| 7|             
                             DAY ON TEST   | 1| 9| 3| 3| 3| 5| 2| 3| 3| 3| 6| 3| 3| 3| 3| 6| 6| 0| 3| 3| 5| 7| 6| 3| 3|             
                                           | 6| 8| 0| 0| 0| 1| 6| 0| 0| 0| 3| 1| 1| 1| 1| 6| 7| 2| 1| 1| 6| 4| 8| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Endometrium, Fibrosis, Focal         |                                                                          |             
      Endometrium, Fibrosis                |             3                                                            |             
      Endometrium, Hyperplasia, Cystic     |                                     2              2                     |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                              +                           |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |          +                                                               |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |    3     4                                                               |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |          2                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                             3            |             
      Hyperplasia, Lymphoid                |                                              3                           |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                3         |             
      Pigmentation                         |                3                          3           2                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lobular                 |                         2                                            3   |             
      Duct, Cyst                           |       2  2  3  3     2  2  2  2  1     2     3  3  3  3  2  3  2  2      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calvarium, Hyperostosis              |                                              2                           |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +                                                  +                     |             
      Diaphragm, Inflammation, Chronic     | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 6| 7| 7|             
                             DAY ON TEST   | 1| 9| 3| 3| 3| 5| 2| 3| 3| 3| 6| 3| 3| 3| 3| 6| 6| 0| 3| 3| 5| 7| 6| 3| 3|             
                                           | 6| 8| 0| 0| 0| 1| 6| 0| 0| 0| 3| 1| 1| 1| 1| 6| 7| 2| 1| 1| 6| 4| 8| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                               3                                          |             
      Hemorrhage                           |                4                                                         |             
      Alveolar Epithelium, Hyperplasia     |                      2                                                   |             
      Lymphatic, Foreign Body              |                                           2                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                           1                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract, Multiple                   |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Nephropathy, Chronic                 |             2  3                 1  2  2     1        2  2  2  3     1  2|             
      Cortex, Cyst                         |                                        3                                 |             
      Medulla, Cyst                        |                                                                X         |             
      Renal Tubule, Dilatation             |                                                                          |             
      Renal Tubule, Mineralization         |       1                          1                                2  1   |             
      Renal Tubule, Pigmentation           |                                                    2              2      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                                          |             
      Transitional Epithelium, Hyperplasia |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 1| 9| 3| 3| 3| 1| 5| 3| 3| 3| 4| 5| 6| 8| 3| 1| 3| 3| 3| 3| 6| 8| 3| 3| 3|            |
                                           | 2| 0| 2| 2| 2| 2| 9| 2| 2| 2| 2| 6| 7| 8| 2| 6| 2| 2| 2| 2| 7| 3| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Serosa, Inflammation, Chronic        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Infiltration Cellular, Lipocyte      |                                  2                                       |      1  2.0|
      Parasite Metazoan                    |                                  2                    2           2      |      6  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     |                                                                1         |      1  1.0|
      Basophilic Focus, Multiple           |       2  2  2  2     2  2  1     2        2     2  1  2  2  1     2  1  1|     35  1.8|
      Eosinophilic Focus                   |             2                                                            |      1  2.0|
      Hematopoietic Cell Proliferation     |                                              2                           |      2  2.0|
      Hepatodiaphragmatic Nodule           | 3                                      3                                 |      4  2.8|
      Hyperplasia, Nodular                 |                               3        2                    3            |      4  3.0|
      Inflammation, Granulomatous, Multiple|                                              2                    2  2   |      5  1.8|
      Mixed Cell Focus                     |                                                                3         |      1  3.0|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            | 2                 2                                                      |      4  2.3|
      Bile Duct, Hyperplasia               |    3  1           3  1                 2              2     3     1      |     14  1.9|
      Centrilobular, Necrosis, Multiple    |                                                                          |      1  4.0|
      Serosa, Hemorrhage                   |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                    +                    +               |   5        |
      Fat, Inflammation, Chronic           |                3                    3                                    |      3  3.3|
      Fat, Necrosis, Focal                 |                3                    2                    2               |      4  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinar Cell, Atrophy                 |                         2              2                          2      |      5  2.0|
      Acinar Cell, Hyperplasia             |                            2                                             |      2  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Forestomach, Edema                   | 4                                                                        |      1  4.0|
      Forestomach, Inflammation, Chronic   |                   2                                                      |      1  2.0|
      Forestomach, Ulcer                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 1| 9| 3| 3| 3| 1| 5| 3| 3| 3| 4| 5| 6| 8| 3| 1| 3| 3| 3| 3| 6| 8| 3| 3| 3|            |
                                           | 2| 0| 2| 2| 2| 2| 9| 2| 2| 2| 2| 6| 7| 8| 2| 6| 2| 2| 2| 2| 7| 3| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                | 2     2  2  2        2  2  2     3  2     2  2     2  2  2     2  2  2  2|     35  2.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |             X                                                           X|      4  2.0|
      Angiectasis                          |                                                                          |      1  4.0|
      Degeneration, Cystic                 |                                                 3              2         |      4  2.3|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hypertrophy, Focal                   |                                                 2                 2      |      3  2.0|
      Vacuolization Cytoplasmic            |                      2              2                                    |      5  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                 2                 2     2|      4  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1  1.0|
      Cyst, Multiple                       |                                                                          |      2  1.0|
      Pars Distalis, Angiectasis           |                         4     2                                   4      |      4  3.3|
      Pars Distalis, Cyst                  |       2  2              1                    2                           |      9  1.8|
      Pars Distalis, Cyst, Multiple        | 3  2        3                          3        2  2  1  1        2      |     16  2.1|
      Pars Distalis, Hyperplasia, Focal    |    2                    3                                   3            |      7  2.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                                                          |      2  2.0|
      C-Cell, Hyperplasia                  |                         2  2     3     2  2                    2         |     10  2.2|
      Follicle, Cyst                       |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia         |                                     3                                    |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
      Hemorrhage                           |                         3                                                |      1  3.0|
      Hyperplasia                          |                                                                   3      |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 1| 9| 3| 3| 3| 1| 5| 3| 3| 3| 4| 5| 6| 8| 3| 1| 3| 3| 3| 3| 6| 8| 3| 3| 3|            |
                                           | 2| 0| 2| 2| 2| 2| 9| 2| 2| 2| 2| 6| 7| 8| 2| 6| 2| 2| 2| 2| 7| 3| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                         3                                                |      4  3.0|
      Necrosis                             |                                                                4         |      1  4.0|
      Duct, Cyst                           |    3     3  3        3        3     3     3        3     3  3  4  3  4  3|     19  3.1|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                3              2                                2         |      5  2.6|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Decidual Reaction                    |                                                                          |      1  2.0|
      Dilatation                           |                                                       3                  |      4  2.5|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Cervix, Cyst                         |                                           3           3                  |      2  3.0|
      Endometrium, Fibrosis, Focal         |                            3                                             |      1  3.0|
      Endometrium, Fibrosis                |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |          3  2                          2           3                     |      6  2.3|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                  +                                       |   2        |
      Cyst                                 |                                  3                                       |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                 +                        |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Myelofibrosis                        |    4                                                                     |      3  3.7|
      Myeloid Cell, Hyperplasia            |                                  4                                       |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Depletion Lymphoid                   |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Pigmentation                         |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation     |                3                             4                           |      3  3.3|
      Pigmentation                         | 3        3                                                           3  3|      7  2.9|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Lymphoid                |                                                    3                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lobular                 |                3                    3  3                                2|      6  2.7|
      Duct, Cyst                           | 2  2  2  2  2  2  3  2  2  3  2     3  2  2  3  2  2  2  2  2  2  2  3  3|     42  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 1| 9| 3| 3| 3| 1| 5| 3| 3| 3| 4| 5| 6| 8| 3| 1| 3| 3| 3| 3| 6| 8| 3| 3| 3|            |
                                           | 2| 0| 2| 2| 2| 2| 9| 2| 2| 2| 2| 6| 7| 8| 2| 6| 2| 2| 2| 2| 7| 3| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Cyst Epithelial Inclusion            |                3                                                         |      1  3.0|
      Hemorrhage                           |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Calvarium, Hyperostosis              |             2                                                            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Diaphragm, Inflammation, Chronic     |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          | 3                                   4        3                 3         |      5  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                    2                     |      2  2.5|
      Hemorrhage                           |                                                                          |      1  4.0|
      Alveolar Epithelium, Hyperplasia     |                         2                                               3|      3  2.3|
      Lymphatic, Foreign Body              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                       2                  |      2  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                           +                              |   1        |
      Cataract, Multiple                   |                                           3                              |      1  3.0|
      Retina, Degeneration                 |                                           3                              |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosis, Focal                      |    3                                                                     |      1  3.0|
      Nephropathy, Chronic                 |    2  1                 1           2     1  2  2              2  2  1  2|     23  1.8|
      Cortex, Cyst                         |                                                                          |      1  3.0|
      Medulla, Cyst                        |                                                                          |      1     |
      Renal Tubule, Dilatation             |    2                                                                     |      1  2.0|
      Renal Tubule, Mineralization         |       1  1                 2     2                 2        2            |     10  1.5|
      Renal Tubule, Pigmentation           |                   2           3                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 5| 7| 7| 7| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 1| 9| 3| 3| 3| 1| 5| 3| 3| 3| 4| 5| 6| 8| 3| 1| 3| 3| 3| 3| 6| 8| 3| 3| 3|            |
                                           | 2| 0| 2| 2| 2| 2| 9| 2| 2| 2| 2| 6| 7| 8| 2| 6| 2| 2| 2| 2| 7| 3| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic, Focal         |                                                             3            |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 2| 5| 6| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 0| 8| 9| 3| 1| 3| 3| 3| 3| 8| 1| 5| 0| 3|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 2| 9| 0| 1| 6| 2| 2| 2| 2| 7| 1| 2| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    225                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +              +              +  +  +  +     +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +              +              +  +  +  +     +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +              A              +  +  +  +     +              +  +  +  A   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +              +              +  +  +  +     +              +  +  M  +   |             
      Parasite Metazoan                    |                2                             1                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +              A              +  +  +  +     +              +  +  +  A   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +              +              +  +  +  +     +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +              +              +  +  +  +     +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +              A              +  +  +  +     +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +              A              +  +  +  +     +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           |    2  2  2  2  2  2  2  2  2     2  2  2  2  2  2  2  2  2     1  2  2  2|             
      Cyst                                 |                                                          3               |             
      Eosinophilic Focus                   |                                                          2               |             
      Eosinophilic Focus, Multiple         |                X                                                         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |    X              3                    3                                 |             
      Hyperplasia, Nodular                 | 3                             3                                          |             
      Inflammation, Granulomatous, Multiple|    2     2                       2                                       |             
      Mixed Cell Focus                     |                   3                 2                                    |             
      Necrosis, Focal                      |                                                                          |             
      Vacuolization Cytoplasmic            | 3                                                                        |             
      Bile Duct, Dilatation                |                                                                          |             
      Bile Duct, Hyperplasia               | 2        1  1                 2  2        2     1                    2   |             
      Serosa, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +           +         |             
      Fat, Inflammation, Chronic           |                                                                3         |             
      Fat, Necrosis, Focal                 |                                                    2                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +              +              +  +  +  +     +              +  +  +  +   |             
      Polyarteritis, Multiple              |                                                                          |             
      Acinar Cell, Atrophy                 |                2                 1                                       |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                     +                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +              +              +  +  +  +     +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +              +              +  +  +  +     +              +  +  +  +   |             
      Forestomach, Edema                   |                                        3                                 |             
      Forestomach, Ulcer                   |                                        3                                 |             
      Glandular, Mineralization            |                                  2                                       |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +              +              +  +  +        +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +              +              +     +  +     +              +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Media, Hypertrophy            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +        +              +  +  +  +     +              +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 2| 5| 6| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 0| 8| 9| 3| 1| 3| 3| 3| 3| 8| 1| 5| 0| 3|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 2| 9| 0| 1| 6| 2| 2| 2| 2| 7| 1| 2| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    225                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Fibrosis, Focal                      |       3                                                                  |             
      Fibrosis, Multiple                   |                               3                                          |             
      Inflammation, Chronic                | 2              3                 1     1     2                 3  2  1   |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +              +           +  +  +  +  +     +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +              +           +  +  +  +  +     +              +  +  +  +   |             
      Accessory Adrenal Cortical Nodule    |                                  2                          X            |             
      Hypertrophy, Focal                   |                                              2                           |             
      Vacuolization Cytoplasmic            |                                     2        2                           |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +              +           +  +  +  +  +     +              +  +  +  +   |             
      Hyperplasia, Focal                   |                                     2                                    |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +              +              +  +  +  +     +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +              +              +  +  +  +     M              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +        +  +     +  M  +  +  +  +     +     +  +     +  +  +  +   |             
      Pars Distalis, Angiectasis           |                                                       4     4  4         |             
      Pars Distalis, Cyst                  |                   2                 3              3              3  2   |             
      Pars Distalis, Cyst, Multiple        | 2                                            2                           |             
      Pars Distalis, Hemorrhage            |                4                                                         |             
      Pars Distalis, Hyperplasia, Focal    |    3              2           3                    3                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +              +     +        +  +  +  +     +        +     +  +  +  +   |             
      Angiectasis                          |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicular Cell, Hyperplasia         |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +              +              M  +  +  +     +  +           +  M  +  +  +|             
      Atrophy                              |                                  2                                       |             
      Hyperplasia                          |                                                                   3      |             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Cyst                           |                                                                   2      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +              +              +  +  +  +     +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +        +  +     +        +  +  +  +     +           +  +  +  +  +  +|             
      Dilatation                           |                                                          3               |             
      Cervix, Cyst                         |                      X                                                   |             
      Endometrium, Hyperplasia, Cystic     |                                                                          |             
      Endometrium, Hyperplasia, Glandular  |                                                                      2   |             
                                            __________________________________________________________________________|             
   Vagina                                  |                      M                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 2| 5| 6| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 0| 8| 9| 3| 1| 3| 3| 3| 3| 8| 1| 5| 0| 3|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 2| 9| 0| 1| 6| 2| 2| 2| 2| 7| 1| 2| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    225                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +              +              +  +  +  +     +              +  +  +  +   |             
      Myeloid Cell, Hyperplasia            |                                              4                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +              +              +  +  +  +  +  +              +  +  +  +   |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +              +              +  +  +  +     +              +  +  +  +   |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +              +              +  +  +  +     +              +  +  +  +   |             
      Depletion Lymphoid                   |                                                                3         |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                2                       2                                 |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                            3        2        4                           |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                3     2           3     2                       3         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +              +              +  +  +  +     +              +  +  +  M   |             
      Atrophy                              |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lobular                 |                            2                                             |             
      Duct, Cyst                           | 2  2     3  2  3     2  2        2  3        3     2  2  2  2  3  3  2  2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +           +              +  +  +  +     +              +  +  +  +   |             
      Ulcer                                |                                                                          |             
      Subcutaneous Tissue, Thrombosis,     |                                                                          |             
           Multiple                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +        +           +  +  +  +  +  +  +              +  +  +  +   |             
      Calvarium, Hyperostosis              |       3                    3              2                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +              +              +  +  +  +     +              +  +  +  +   |             
      Compression                          |                                                             2            |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +        +  +           +  +  +  +  +  +  +  +        +  +  +  +   |             
      Congestion                           |                3                                                     3   |             
      Alveolus, Pigmentation               |                                                                          |             
      Lymphatic, Foreign Body              |                2                                                     2   |             
      Mediastinum, Foreign Body            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 2| 5| 6| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 0| 8| 9| 3| 1| 3| 3| 3| 3| 8| 1| 5| 0| 3|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 2| 9| 0| 1| 6| 2| 2| 2| 2| 7| 1| 2| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    225                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +              +              +  +  +  +     +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +              +              +  +  +  +     +              +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                        +                                 |             
      Inflammation, Suppurative            |                                        4                                 |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Edema                        |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                        +                                 |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +              +              +  +  +  +     +              +  +  +  +   |             
      Nephropathy, Chronic                 |                2                 1                                1      |             
      Renal Tubule, Degeneration           |                                                                          |             
      Renal Tubule, Mineralization         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +              +              +  +  +  +     +              +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 3| 7| 7| 7| 7| 3| 5| 6| 7| 7| 3| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 8| 3| 3| 3| 1| 8| 0| 3| 3| 3| 0| 1| 3| 3| 6| 0| 8| 3| 3| 7| 3| 3| 3| 3|            |
                                           | 8| 2| 2| 2| 2| 7| 2| 8| 2| 2| 7| 8| 0| 2| 2| 6| 1| 9| 2| 2| 6| 1| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    225                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +           +  +  +        +  +  +        +  +  +        +  +         |  24        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  A           M  +  +        +  +  +        +  +  +        +  +         |  22        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A           M  +  +        +  +  +        +  +  +        A  A         |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  A           M  M  +        +  +  +        +  +  +        +  +         |  20        |
      Parasite Metazoan                    |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A           M  +  +        +  +  +        +  +  +        +  +         |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +           +  +  +        +  +  +        +  +  +        +  +         |  24        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +           M  +  +        +  +  +        +  +  +        +  +         |  23        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A           +  A  +        +  +  +        +  +  +        +  A         |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A           M  +  +        +  +  +        +  +  +        +  A         |  20        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus, Multiple           |    2  2  2  2     2  2  2  3     2  2  2  2        2     2     2  2  2  2|     40  2.0|
      Cyst                                 |                                                                          |      1  3.0|
      Eosinophilic Focus                   |             2        2                                                   |      3  2.0|
      Eosinophilic Focus, Multiple         |                                                    2                     |      2  2.0|
      Hematopoietic Cell Proliferation     |                            2        1                                    |      2  1.5|
      Hepatodiaphragmatic Nodule           |                3     X                                                   |      5  3.0|
      Hyperplasia, Nodular                 |                   2                                   3                  |      4  2.8|
      Inflammation, Granulomatous, Multiple| 2        2                 2              1              1           2   |      9  1.8|
      Mixed Cell Focus                     |                                                                          |      2  2.5|
      Necrosis, Focal                      |    2                                                                     |      1  2.0|
      Vacuolization Cytoplasmic            |                      2                                                   |      2  2.5|
      Bile Duct, Dilatation                |                                           3                              |      1  3.0|
      Bile Duct, Hyperplasia               |             2     2     1           1     2           2        2         |     15  1.7|
      Serosa, Inflammation, Suppurative    |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                                                         |   3        |
      Fat, Inflammation, Chronic           |                                                                          |      1  3.0|
      Fat, Necrosis, Focal                 |                4                                                         |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +           +  +  +        +  +  +        +  +  +        +  +         |  24        |
      Polyarteritis, Multiple              |                4                                                         |      1  4.0|
      Acinar Cell, Atrophy                 |                      1                                         2         |      4  1.5|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                  +                                       |   2        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +           +  +  +        +  +  +        +  +  +        +  +         |  24        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +           +  +  +        +  +  +        +  +  +        +  +         |  24        |
      Forestomach, Edema                   |                      3                                                   |      2  3.0|
      Forestomach, Ulcer                   |                      3                                                   |      2  3.0|
      Glandular, Mineralization            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +              +           +  +  +        +  +  +        +  +         |  21        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +              +  +        +  +  +        +  +  +        +  +         |  22        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 3| 7| 7| 7| 7| 3| 5| 6| 7| 7| 3| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 8| 3| 3| 3| 1| 8| 0| 3| 3| 3| 0| 1| 3| 3| 6| 0| 8| 3| 3| 7| 3| 3| 3| 3|            |
                                           | 8| 2| 2| 2| 2| 7| 2| 8| 2| 2| 7| 8| 0| 2| 2| 6| 1| 9| 2| 2| 6| 1| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    225                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                +                                                         |   1        |
      Aorta, Media, Hypertrophy            |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +           +  +  +        +  +  +        +  +  +        +  +         |  25        |
      Fibrosis, Focal                      |                                                                          |      1  3.0|
      Fibrosis, Multiple                   |                                                                          |      1  3.0|
      Inflammation, Chronic                |    1              2  2                          3              2         |     13  1.9|
      Atrium, Thrombosis                   |                4                                                         |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +           +  +  +        +  +  +        +  +  +        +  +         |  25        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +           +  +  +        +  +  +        +  +  +        +  +         |  25        |
      Accessory Adrenal Cortical Nodule    |                   2                 2                                    |      4  2.0|
      Hypertrophy, Focal                   |                4                                   2                     |      3  2.7|
      Vacuolization Cytoplasmic            |                      2                                                   |      3  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +           +  +  +        +  +  +        +  +  +        +  +         |  25        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +           +  +  +        +  +  +        +  +  +        +  +         |  24        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +           +  +  +        +  +  +        +  +  +        +  +         |  23        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +        M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +|  37        |
      Pars Distalis, Angiectasis           |                      4              2           4        3  4           4|      9  3.7|
      Pars Distalis, Cyst                  |                                  2                                       |      6  2.5|
      Pars Distalis, Cyst, Multiple        |                         2     2        2     1                 2         |      7  1.9|
      Pars Distalis, Hemorrhage            |                   4                                4                     |      3  4.0|
      Pars Distalis, Hyperplasia, Focal    |                                  2     2                       3         |      7  2.6|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +           +  +  +     +  +  +  +        +  +  +        +  +         |  27        |
      Angiectasis                          |                                     3                                    |      1  3.0|
      Degeneration, Cystic                 |                   2                                                      |      1  2.0|
      C-Cell, Hyperplasia                  |                      2     2                                             |      2  2.0|
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  +        M  +  +        +  +  +        +  +  +        M  +         |  22        |
      Atrophy                              |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 3| 7| 7| 7| 7| 3| 5| 6| 7| 7| 3| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 8| 3| 3| 3| 1| 8| 0| 3| 3| 3| 0| 1| 3| 3| 6| 0| 8| 3| 3| 7| 3| 3| 3| 3|            |
                                           | 8| 2| 2| 2| 2| 7| 2| 8| 2| 2| 7| 8| 0| 2| 2| 6| 1| 9| 2| 2| 6| 1| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    225                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |       2                          3                                       |      2  2.5|
      Duct, Cyst                           |       3                                            3           2         |      4  2.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +           +  +  +        +  +  +        +  +  +        +  +         |  24        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +           +  +  +        +  +  +        +  +  +  +     +  +  +     +|  32        |
      Dilatation                           |                                                                          |      1  3.0|
      Cervix, Cyst                         |                                                                          |      1     |
      Endometrium, Hyperplasia, Cystic     |                                     3              3                    3|      3  3.0|
      Endometrium, Hyperplasia, Glandular  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +           +  +  +        +  +  +        +  +  +        +  +         |  24        |
      Myeloid Cell, Hyperplasia            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +           +  +  +        +  +  +        +  +  +  +     +  +         |  26        |
      Mediastinal, Hyperplasia, Lymphoid   |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M           +  +  +        +  +  +        +  +  +        +  +         |  23        |
      Hyperplasia, Lymphoid                |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +           +  +  +        +  +  +        +  +  +        +  +         |  24        |
      Depletion Lymphoid                   |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                3                                                         |      1  3.0|
      Pigmentation                         | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      2  2.0|
      Fibrosis                             |                2                                                         |      1  2.0|
      Hematopoietic Cell Proliferation     |                2           2  3     4                             2      |      8  2.8|
      Necrosis                             |                3                                                         |      1  3.0|
      Pigmentation                         |    2                 3                          3  2                     |      9  2.6|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +           +  +  +        +  +  +        +  +  +        M  M         |  21        |
      Atrophy                              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lobular                 |          2     2        2                 2                       2  2   |      7  2.0|
      Duct, Cyst                           | 2  3  2  2        2  2     3     2  3     2        3  3  2     3  3  2  4|     35  2.4|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +        +  +  +  +     +  +  +  +     +  +  +        +  +         |  28        |
      Ulcer                                |                                                                4         |      1  4.0|
      Subcutaneous Tissue, Thrombosis,     |                                                                          |            |
           Multiple                        |                3                                                         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 3| 7| 7| 7| 7| 3| 5| 6| 7| 7| 3| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 8| 3| 3| 3| 1| 8| 0| 3| 3| 3| 0| 1| 3| 3| 6| 0| 8| 3| 3| 7| 3| 3| 3| 3|            |
                                           | 8| 2| 2| 2| 2| 7| 2| 8| 2| 2| 7| 8| 0| 2| 2| 6| 1| 9| 2| 2| 6| 1| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    225                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +           +  +  +        +  +  +        +  +  +     +  +  +         |  28        |
      Calvarium, Hyperostosis              |                                                          2               |      4  2.5|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +           +  +  +        +  +  +        +  +  +        +  +         |  24        |
      Compression                          | 4                 3  3                          3  3                     |      6  3.0|
      Hydrocephalus                        |                                                 4                        |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +           +  +  +        +  +  +        +  +  +        +  +  +      |  30        |
      Congestion                           |    2              3                             3                        |      5  2.8|
      Alveolus, Pigmentation               |                                     1                                    |      1  1.0|
      Lymphatic, Foreign Body              |                                                                          |      2  2.0|
      Mediastinum, Foreign Body            |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +           +  +  +        +  +  +        +  +  +        +  +         |  24        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +           +  +  +        +  +  +        +  +  +        +  +         |  24        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                +         |   1        |
      Cornea, Edema                        |                                                                3         |      1  3.0|
      Retina, Degeneration                 |                                                                3         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                               +                                          |   2        |
      Inflammation, Suppurative            |                               4                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +           +  +  +        +  +  +        +  +  +        +  +         |  24        |
      Nephropathy, Chronic                 | 1                 2  3                             2                     |      7  1.7|
      Renal Tubule, Degeneration           | 2                                                                        |      1  2.0|
      Renal Tubule, Mineralization         |    1                                                           2         |      2  1.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +           +  +  +        +  +  +        +  +  +        +  +         |  24        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 7| 7| 7| 2| 3| 5| 6| 7| 6| 6| 6| 7| 7| 4| 5| 6| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 3| 3| 3| 2| 2| 9| 5| 2| 6| 7| 8| 3| 3| 5| 9| 7| 3| 3| 8| 3| 3| 3| 3|             
                                           | 1| 6| 0| 0| 1| 0| 5| 6| 3| 6| 9| 0| 7| 1| 1| 2| 6| 0| 1| 1| 4| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    450                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | 2                    2                                   2               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  +  +  +  +  +  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                3         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                            1                                             |             
      Basophilic Focus, Multiple           |       1  2  1           1     2  2     2  2  1  2  3  2  2  2  2  2     2|             
      Clear Cell Focus                     |                   2                                                      |             
      Eosinophilic Focus                   |                                     3                                    |             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     |                                              2                           |             
      Hepatodiaphragmatic Nodule           | 2                 2                 3                       3            |             
      Hyperplasia, Nodular                 |    2                 2              3                                    |             
      Inflammation, Granulomatous, Multiple|                                  2        2           2        2         |             
      Mixed Cell Focus                     |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Bile Duct, Hyperplasia               |                         2  2        2                 2                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
      Fat, Inflammation, Focal,            |                                                                          |             
          Granulomatous                    |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinar Cell, Atrophy                 |       2                       3                    2  2                  |             
      Acinar Cell, Hyperplasia             |             2                          2     3        2                  |             
      Acinar Cell, Hyperplasia, Multiple   |                                                                          |             
      Duct, Cyst                           |                                                          4               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Edema                   |                   3                                                      |             
      Forestomach, Inflammation, Chronic   |    3                                                                     |             
      Forestomach, Ulcer                   |    3              2                                                      |             
      Forestomach, Ulcer, Multiple         |                                                                          |             
      Glandular, Cyst, Multiple            |    2                                                                     |             
      Glandular, Mineralization            |                                                                2  3      |             
      Glandular, Epithelium, Hyperplasia   |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 7| 7| 7| 2| 3| 5| 6| 7| 6| 6| 6| 7| 7| 4| 5| 6| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 3| 3| 3| 2| 2| 9| 5| 2| 6| 7| 8| 3| 3| 5| 9| 7| 3| 3| 8| 3| 3| 3| 3|             
                                           | 1| 6| 0| 0| 1| 0| 5| 6| 3| 6| 9| 0| 7| 1| 1| 2| 6| 0| 1| 1| 4| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    450                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +        +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                  +                                       |             
      Hyperplasia, Squamous                |                                  3                                       |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                      +   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                            4                                             |             
      Fibrosis, Multiple                   |                                     3                                    |             
      Inflammation, Chronic                |       2  3  2           2  2           2  3     2  2  2     2  2        2|             
      Atrium, Congestion                   |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                        2                                 |             
      Congestion                           |                                                                          |             
      Degeneration, Cystic                 |                                                                1         |             
      Hypertrophy, Focal                   |                                     2                          2         |             
      Vacuolization Cytoplasmic            |                                        2                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Congestion                           |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                   1                                                      |             
      Pars Distalis, Cyst                  |          3                                                               |             
      Pars Distalis, Cyst, Multiple        |                      2              2                       1            |             
      Pars Distalis, Hyperplasia, Focal    |                                  2                                       |             
      Pars Distalis, Inflammation, Focal,  |                                                                          |             
           Granulomatous                   |                                        1                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                               2                                2  2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                               +                    +                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  M  +  +  +|             
      Atrophy                              |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 7| 7| 7| 2| 3| 5| 6| 7| 6| 6| 6| 7| 7| 4| 5| 6| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 3| 3| 3| 2| 2| 9| 5| 2| 6| 7| 8| 3| 3| 5| 9| 7| 3| 3| 8| 3| 3| 3| 3|             
                                           | 1| 6| 0| 0| 1| 0| 5| 6| 3| 6| 9| 0| 7| 1| 1| 2| 6| 0| 1| 1| 4| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    450                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |                                                                          |             
      Inflammation, Suppurative            |    4                       4     4                                       |             
      Metaplasia, Squamous                 |                                  3                                       |             
      Duct, Cyst                           |          4           3     4              3                              |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    2                     |             
      Hyperplasia, Tubular                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Decidual Reaction                    |                                                                          |             
      Dilatation                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                     2     2           2  3               |             
      Endometrium, Hyperplasia, Glandular  |                                                                   2      |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +                                            +                    +   |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Reticulum Cell          |                                           3                              |             
      Myelofibrosis                        |                      3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pancreatic, Inflammation,            |                                                                          |             
          Granulomatous                    |                3                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Fibrosis                             |                            4                                             |             
      Hematopoietic Cell Proliferation     |                                  3           4                           |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Multiple                       |                                                                   2      |             
      Hemorrhage                           |                3                                                         |             
      Mediastinum, Hemorrhage              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lobular                 |                                                                2         |             
      Duct, Cyst                           |    3     2           2  4  2        3  2              2     2  2         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calvarium, Hyperostosis              |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 7| 7| 7| 2| 3| 5| 6| 7| 6| 6| 6| 7| 7| 4| 5| 6| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 3| 3| 3| 2| 2| 9| 5| 2| 6| 7| 8| 3| 3| 5| 9| 7| 3| 3| 8| 3| 3| 3| 3|             
                                           | 1| 6| 0| 0| 1| 0| 5| 6| 3| 6| 9| 0| 7| 1| 1| 2| 6| 0| 1| 1| 4| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    450                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Femur, Fracture                      |                                              4                           |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 3              3        2                                                |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Pigmentation               |          2                                                     2         |             
      Bronchus, Foreign Body               |                                                 2                        |             
      Lymphatic, Foreign Body              |                3                                                         |             
      Mediastinum, Edema                   |                                                                          |             
      Mediastinum, Foreign Body            | 2                                                                        |             
      Mediastinum, Hemorrhage              |                                                                          |             
      Peribronchial, Infiltration Cellular,|                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |          +                                   +                       +   |             
                                            __________________________________________________________________________|             
   Eye                                     |                   M                                                  +   |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct, Multiple                    |                                        3                                 |             
      Nephropathy, Chronic                 |    1                       1  2  1  1        1              3  1  1      |             
      Renal Tubule, Dilatation             |                                        3                                 |             
      Renal Tubule, Mineralization         |          1              1     2  1  2  2        1  2  2  1     2         |             
      Renal Tubule, Pigmentation           |                      2              3        2                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 5| 5| 6| 6| 1| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 7| 9| 6| 7| 4| 6| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 8| 9| 8| 7| 8| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    450                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    | 2                                   2     2           2                  |      7  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  A  +  +     A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
      Parasite Metazoan                    |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                         3|      1  3.0|
      Basophilic Focus                     |                                                                          |      1  1.0|
      Basophilic Focus, Multiple           |    2     2  2     2     2  2  2  2           1  2  2  2     2  2     2   |     32  1.9|
      Clear Cell Focus                     |                                  3                                       |      2  2.5|
      Eosinophilic Focus                   |                                                                          |      1  3.0|
      Fibrosis, Focal                      |                                                                         3|      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                        2                             3   |      6  2.5|
      Hyperplasia, Nodular                 |                                                                          |      3  2.3|
      Inflammation, Granulomatous, Multiple|                         2  2        2                 2              2  3|     10  2.1|
      Mixed Cell Focus                     |                                        2  2        1                 2   |      4  1.8|
      Vacuolization Cytoplasmic            |                                              2                           |      1  2.0|
      Bile Duct, Hyperplasia               |          1  2        1     2        2                             1      |     10  1.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                           +                    +        +|   4        |
      Fat, Inflammation, Focal,            |                                                                          |            |
          Granulomatous                    |                                                                         3|      1  3.0|
      Fat, Necrosis, Focal                 |                                           3                    2         |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinar Cell, Atrophy                 |                         2                                   2            |      6  2.2|
      Acinar Cell, Hyperplasia             |                            2                                             |      5  2.2|
      Acinar Cell, Hyperplasia, Multiple   |                               2                                          |      1  2.0|
      Duct, Cyst                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Forestomach, Edema                   | 3                                                                        |      2  3.0|
      Forestomach, Inflammation, Chronic   |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 5| 5| 6| 6| 1| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 7| 9| 6| 7| 4| 6| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 8| 9| 8| 7| 8| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    450                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Forestomach, Ulcer                   |                2                                                         |      3  2.3|
      Forestomach, Ulcer, Multiple         | 2     3                                                                  |      2  2.5|
      Glandular, Cyst, Multiple            |                                                                          |      1  2.0|
      Glandular, Mineralization            |                            2                    2                        |      4  2.3|
      Glandular, Epithelium, Hyperplasia   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Hyperplasia, Squamous                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                              +                           |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  4.0|
      Fibrosis, Multiple                   |                                                                          |      1  3.0|
      Inflammation, Chronic                |    2  3     2     2  2     2     2  2           2  2  2  2  2  2     2  2|     29  2.1|
      Atrium, Congestion                   |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                        X                                 |      2  2.0|
      Congestion                           | 2                                                                        |      1  2.0|
      Degeneration, Cystic                 |                                     3                                    |      2  2.0|
      Hypertrophy, Focal                   |                      2                                         2  2     3|      6  2.2|
      Vacuolization Cytoplasmic            |             3                       2                                    |      3  2.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                           4                              |      1  4.0|
      Congestion                           | 2                                                                        |      1  2.0|
      Hyperplasia, Focal                   |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  48        |
      Pars Distalis, Angiectasis           |                                           2              4           4   |      4  2.8|
      Pars Distalis, Cyst                  |                      1           2        2     3                        |      5  2.2|
      Pars Distalis, Cyst, Multiple        |                                     2                                3  2|      6  2.0|
      Pars Distalis, Hyperplasia, Focal    |                2                 2     3              3  3               |      6  2.5|
      Pars Distalis, Inflammation, Focal,  |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 5| 5| 6| 6| 1| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 7| 9| 6| 7| 4| 6| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 8| 9| 8| 7| 8| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    450                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
           Granulomatous                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |                                                                          |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Atrophy                              |                                                                          |      1  2.0|
      Fibrosis                             |    3                                                                     |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      3  4.0|
      Metaplasia, Squamous                 |                                                                          |      1  3.0|
      Duct, Cyst                           |          4                    4  3     2                          2  3  4|     11  3.3|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                      3  3|      3  2.7|
      Hyperplasia, Tubular                 |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Decidual Reaction                    |                                     3                                    |      1  3.0|
      Dilatation                           |                      2  3                                                |      2  2.5|
      Endometrium, Hyperplasia, Cystic     |                         2           3                    2               |      7  2.3|
      Endometrium, Hyperplasia, Glandular  |                                                    3                     |      2  2.5|
                                            __________________________________________________________________________|____________|
   Vagina                                  |    +              +                          +                           |   4        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |       +                                                                  |   4        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Reticulum Cell          |                                                                      3   |      2  3.0|
      Myelofibrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pancreatic, Inflammation,            |                                                                          |            |
          Granulomatous                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                2                                                         |      1  2.0|
      Fibrosis                             |                                                                          |      1  4.0|
      Hematopoietic Cell Proliferation     |       3                                                                  |      3  3.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 5| 5| 6| 6| 1| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 7| 9| 6| 7| 4| 6| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 8| 9| 8| 7| 8| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    450                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pigmentation                         |             3  2                             3                           |      3  2.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst, Multiple                       |                                                          2               |      2  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Mediastinum, Hemorrhage              | 4                                                                        |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lobular                 |                                  2        2                              |      3  2.0|
      Duct, Cyst                           |          4  3     3  2        2     X  3        2     2  2  2        3  2|     23  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Calvarium, Hyperostosis              |                                                       3                  |      2  2.5|
      Femur, Fracture                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           | 3           3     3                                                      |      6  2.8|
      Alveolar Epithelium, Hyperplasia     |                                                                   3      |      1  3.0|
      Alveolus, Pigmentation               |                                                                          |      2  2.0|
      Bronchus, Foreign Body               |                                                                          |      1  2.0|
      Lymphatic, Foreign Body              |                                                                          |      1  3.0|
      Mediastinum, Edema                   |                3                                                         |      1  3.0|
      Mediastinum, Foreign Body            | 3                                                                        |      2  2.5|
      Mediastinum, Hemorrhage              | 3              2                                                         |      2  2.5|
      Peribronchial, Infiltration Cellular,|                                                                          |            |
           Lymphocyte                      |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 5| 5| 6| 6| 1| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 7| 9| 6| 7| 4| 6| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 8| 9| 8| 7| 8| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    450                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                              +  +                        |   5        |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                   +                        |   3        |
      Cataract                             |             3                                   3                        |      2  3.0|
      Retina, Degeneration                 |             3                                   3                        |      2  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                              +                           |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infarct, Multiple                    |                                                                          |      1  3.0|
      Nephropathy, Chronic                 |                         1           2  1  2     1     1     1     1  1  1|     19  1.3|
      Renal Tubule, Dilatation             |                                                                          |      1  3.0|
      Renal Tubule, Mineralization         |       2                    2  1  1                    2        2     1  2|     19  1.6|
      Renal Tubule, Pigmentation           |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 6| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 7| 8| 7| 2| 2| 6| 1| 0| 2| 2| 4| 2| 2| 2| 2| 2| 7| 8| 2| 2| 7| 6| 2| 2| 2|             
                                           | 5| 0| 4| 9| 9| 5| 8| 0| 9| 9| 3| 9| 9| 9| 9| 9| 4| 1| 9| 9| 0| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          2                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                            X                    2        2               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                            1        1                                    |             
      Basophilic Focus, Multiple           |          1  2           2     2                       2  1           2  1|             
      Clear Cell Focus                     |                   1        2                                      1      |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |          2                                               2               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |                   2           2           2                              |             
      Hyperplasia, Nodular                 |                      3                    2  2              3            |             
      Inflammation, Granulomatous, Multiple|          1                                                               |             
      Mixed Cell Focus                     |             2                                                            |             
      Mixed Cell Focus, Multiple           |                                                                          |             
      Vacuolization Cytoplasmic            |    2  3           2  2        2                                          |             
      Bile Duct, Hyperplasia               | 1  1  1  1  1  1  1  1  1  2  1  1  2  1  2  2  3  2  1  2  2  4  1  2  1|             
      Centrilobular, Degeneration          |                                                    2                     |             
      Centrilobular, Necrosis              |                                                                3         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +  +                    +     +           +         |             
      Metaplasia, Osseous                  |                                                                3         |             
      Fat, Mineralization, Focal           |                                                                          |             
      Fat, Necrosis, Focal                 |                      3  3                    3     3                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyarteritis                        |                                     3                                    |             
      Acinar Cell, Atrophy                 |       2           2           3  2  2  2                    2  4        1|             
      Acinar Cell, Hyperplasia             |                                                                   2      |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Palate, Hyperplasia, Squamous        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Forestomach, Edema                   |       4                                                                  |             
      Forestomach, Inflammation, Chronic   |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 6| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 7| 8| 7| 2| 2| 6| 1| 0| 2| 2| 4| 2| 2| 2| 2| 2| 7| 8| 2| 2| 7| 6| 2| 2| 2|             
                                           | 5| 0| 4| 9| 9| 5| 8| 0| 9| 9| 3| 9| 9| 9| 9| 9| 4| 1| 9| 9| 0| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Forestomach, Mineralization          |                                                                          |             
      Forestomach, Polyarteritis           |                                                                          |             
      Forestomach, Ulcer                   |                                                                          |             
      Forestomach, Epithelium, Hyperplasia |       3                                                                  |             
      Glandular, Mineralization            |                                  2                                       |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                       +                  |             
      Inflammation, Focal                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Mesenteric Artery, Polyarteritis     |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 3  2  3  2  3     2  2  2  3  3     2  2  2  2  3     2  1  2  1  2  2   |             
      Valve, Bacterium                     |                                                                          |             
      Valve, Thrombosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |       2  3                                               2               |             
      Hypertrophy, Focal                   |                                                       2  2               |             
      Vacuolization Cytoplasmic            |       2        2  4                                2           2  2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                   2  2                                                   |             
      Vacuolization Cytoplasmic            |                   4                                                      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hyperplasia                          |                         2                                                |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 4                                3                    2                  |             
      Pars Distalis, Cyst                  |                                                       2  2               |             
      Pars Distalis, Cyst, Multiple        |    2                                                                     |             
      Pars Distalis, Hyperplasia, Focal    |    2                                                  2              2  2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
      C-Cell, Hyperplasia                  |                         2              2           2  2        2  2  2  1|             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 6| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 7| 8| 7| 2| 2| 6| 1| 0| 2| 2| 4| 2| 2| 2| 2| 2| 7| 8| 2| 2| 7| 6| 2| 2| 2|             
                                           | 5| 0| 4| 9| 9| 5| 8| 0| 9| 9| 3| 9| 9| 9| 9| 9| 4| 1| 9| 9| 0| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2                             3  2  3        2  2        3  3      |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic                |                                        3  2              3               |             
      Inflammation, Suppurative            | 3              3        3        3                                       |             
      Duct, Cyst                           |                   3  3           4  3     2        3           4         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 3     3                       3        3     2           1  2        1   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                2                 3  4     3                    2  3  3   |             
      Necrosis                             |                                                                          |             
      Bilateral, Interstitial Cell,        |                                                                          |             
          Hyperplasia                      |    2                          3                             2            |             
      Interstitial Cell, Atrophy           |                                                                         3|             
      Interstitial Cell, Hyperplasia       |       2                          2        2        2                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                    +                     |             
      Leukocytosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                   3      |             
      Myelofibrosis                        |                                                    2                     |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Lymphoid      |                                  2                                       |             
      Mediastinal, Hyperplasia, Lymphoid   |                                           3                              |             
      Pancreatic, Hyperplasia, Lymphoid    |                            2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                  3        3                       3  3   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst, Multiple                       |                                                                          |             
      Hyperplasia, Lymphoid                |                                           3                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                    3                     |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                  3                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  M  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 6| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 7| 8| 7| 2| 2| 6| 1| 0| 2| 2| 4| 2| 2| 2| 2| 2| 7| 8| 2| 2| 7| 6| 2| 2| 2|             
                                           | 5| 0| 4| 9| 9| 5| 8| 0| 9| 9| 3| 9| 9| 9| 9| 9| 4| 1| 9| 9| 0| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +|             
      Hyperplasia, Lobular                 |                                                                          |             
      Duct, Cyst                           |       3     3                          2                       2         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                         X                                                |             
      Fibrosis                             |                                        2                                 |             
      Ulcer                                |                                                                          |             
      Epidermis, Hyperplasia, Focal        |                                                                          |             
      Epidermis, Hyperplasia               |                                        2                                 |             
      Subcutaneous Tissue, Hemorrhage,     |                                                                          |             
           Chronic                         |                                                                          |             
      Subcutaneous Tissue, Necrosis        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +         |             
      Abdominal, Metaplasia, Osseous       |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |       4                                                                  |             
      Hemorrhage                           | 2              3                                                         |             
      Hippocampus, Vacuolization           |                                                                          |             
          Cytoplasmic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 4           2              2  4                                          |             
      Edema                                |                               2                                          |             
      Foreign Body                         |                         2  2                                             |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                         3                                                |             
      Alveolar Epithelium, Hyperplasia     |                      3                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Foreign Body                  |                                           2                              |             
      Lumen, Fungus                        |                            2                       2           2     2  3|             
      Lumen, Inflammation, Suppurative     |                2           2                       2           2     2  2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 6| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 7| 8| 7| 2| 2| 6| 1| 0| 2| 2| 4| 2| 2| 2| 2| 2| 7| 8| 2| 2| 7| 6| 2| 2| 2|             
                                           | 5| 0| 4| 9| 9| 5| 8| 0| 9| 9| 3| 9| 9| 9| 9| 9| 4| 1| 9| 9| 0| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +              +        +                          +                     |             
      Cataract                             |                                                    3                     |             
      Hemorrhage                           |                4                                                         |             
      Inflammation, Suppurative            |                4                                                         |             
      Retina, Degeneration                 | 2              4                                   4                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                                         |             
      Pigmentation                         |                4                                                         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Infarct                              |    3                                                                     |             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy, Chronic                 | 2  3  3  3  2  2        2  2  2  2  2  2  2  2     2  2  2  2  3  2  2  2|             
      Renal Tubule, Mineralization         |                                                                          |             
      Renal Tubule, Pigmentation           |                                              2                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 5| 6| 7| 6| 6| 6| 7| 7| 4| 4| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 8| 7| 9| 5| 2| 2| 6| 6| 2| 2| 8| 9| 1| 0| 2| 6| 4| 3| 3| 3| 2| 6| 3| 3| 3|            |
                                           | 1| 7| 6| 1| 9| 4| 3| 8| 9| 9| 1| 8| 4| 8| 9| 9| 1| 0| 0| 0| 9| 4| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  47        |
      Parasite Metazoan                    |             2              2                       2        2            |      7  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia, Lymphoid                |             3                                            3               |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia, Lymphoid                |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | 1           1                       3  2                          1      |      7  1.4|
      Basophilic Focus, Multiple           |                                                    2  1  2  2        2   |     13  1.7|
      Clear Cell Focus                     |                                                          1               |      4  1.3|
      Degeneration, Cystic                 |                                           2                              |      1  2.0|
      Eosinophilic Focus                   |                                                    3                 1   |      4  2.0|
      Hematopoietic Cell Proliferation     |                                     2                                    |      1  2.0|
      Hemorrhage                           |    2                                                                     |      1  2.0|
      Hepatodiaphragmatic Nodule           |          2                 3                                             |      5  2.2|
      Hyperplasia, Nodular                 |                                                                          |      4  2.5|
      Inflammation, Granulomatous, Multiple|                                                                          |      1  1.0|
      Mixed Cell Focus                     |             1              2                                             |      3  1.7|
      Mixed Cell Focus, Multiple           |                                                                         2|      1  2.0|
      Vacuolization Cytoplasmic            |                3                                                         |      6  2.3|
      Bile Duct, Hyperplasia               | 2  2  2  2  2  2  2     1  2  2     1  2  2     2  2        2  2  2  2  1|     45  1.7|
      Centrilobular, Degeneration          | 3                                                                        |      2  2.5|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +     +     +        +     +                 +                     |  11        |
      Metaplasia, Osseous                  |                                                                          |      1  3.0|
      Fat, Mineralization, Focal           |                                  2                                       |      1  2.0|
      Fat, Necrosis, Focal                 |       3     3              2     3                 3                     |      9  2.9|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Polyarteritis                        |                            3                                4            |      3  3.3|
      Acinar Cell, Atrophy                 | 2  2  2     2  2                                            2     2  2  2|     18  2.1|
      Acinar Cell, Hyperplasia             |                         2                                                |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                +                                                         |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 5| 6| 7| 6| 6| 6| 7| 7| 4| 4| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 8| 7| 9| 5| 2| 2| 6| 6| 2| 2| 8| 9| 1| 0| 2| 6| 4| 3| 3| 3| 2| 6| 3| 3| 3|            |
                                           | 1| 7| 6| 1| 9| 4| 3| 8| 9| 9| 1| 8| 4| 8| 9| 9| 1| 0| 0| 0| 9| 4| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Palate, Hyperplasia, Squamous        |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Forestomach, Edema                   |                                                                          |      1  4.0|
      Forestomach, Inflammation, Chronic   |                                                                3         |      2  3.0|
      Forestomach, Mineralization          |    2                                                                     |      1  2.0|
      Forestomach, Polyarteritis           |                                                             3            |      1  3.0|
      Forestomach, Ulcer                   |                                                                4         |      1  4.0|
      Forestomach, Epithelium, Hyperplasia |                                                                          |      1  3.0|
      Glandular, Mineralization            |    2                                                                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +        +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |             +           +                                                |   3        |
      Inflammation, Focal                  |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                            +                                             |   1        |
      Mesenteric Artery, Polyarteritis     |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                | 3  2  2  2  2  3  3  2  2  2  3  3  3  2  2  3  2  2  2  2  2  2  2  3  2|     46  2.3|
      Valve, Bacterium                     |                4                                                         |      1  4.0|
      Valve, Thrombosis                    |                4                                                         |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Focal                   |                                  3                                      3|      5  2.6|
      Hypertrophy, Focal                   |                                                                          |      2  2.0|
      Vacuolization Cytoplasmic            |          2  2        1                                      2  3         |     11  2.2|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Focal                   |                                           2                 2        2   |      5  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  46        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Angiectasis           |                                                                          |      3  3.0|
      Pars Distalis, Cyst                  |          2                 2                                             |      4  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 5| 6| 7| 6| 6| 6| 7| 7| 4| 4| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 8| 7| 9| 5| 2| 2| 6| 6| 2| 2| 8| 9| 1| 0| 2| 6| 4| 3| 3| 3| 2| 6| 3| 3| 3|            |
                                           | 1| 7| 6| 1| 9| 4| 3| 8| 9| 9| 1| 8| 4| 8| 9| 9| 1| 0| 0| 0| 9| 4| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Cyst, Multiple        |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia, Focal    |       2                                               2  2              1|      8  1.9|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  |                         3                                                |      1  3.0|
      C-Cell, Hyperplasia                  |                                                          2               |      9  1.9|
      Follicle, Cyst                       |                                                             2     2      |      2  2.0|
      Follicular Cell, Hyperplasia         |                                                             2            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                +         |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              | 3        2              2     3                                          |     12  2.5|
      Fibrosis                             | 4                                                                        |      1  4.0|
      Inflammation, Chronic                |                               3                                          |      4  2.8|
      Inflammation, Suppurative            | 3                    3              4                                2   |      8  3.0|
      Duct, Cyst                           |          3                 2                                         2   |     10  2.9|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |    2              2                             3        2  2  3  2  2   |     16  2.3|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       3           2  4  2              2           4  4           2      |     15  2.9|
      Necrosis                             |                4                                                         |      1  4.0|
      Bilateral, Interstitial Cell,        |                                                                          |            |
          Hyperplasia                      |    2                                2  2                       2        2|      8  2.1|
      Interstitial Cell, Atrophy           |          4                                                               |      2  3.5|
      Interstitial Cell, Hyperplasia       |          2                    2           2                              |      7  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                     +                                    |   2        |
      Leukocytosis                         |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Myelofibrosis                        |                                                                          |      1  2.0|
      Myeloid Cell, Hyperplasia            |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 5| 6| 7| 6| 6| 6| 7| 7| 4| 4| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 8| 7| 9| 5| 2| 2| 6| 6| 2| 2| 8| 9| 1| 0| 2| 6| 4| 3| 3| 3| 2| 6| 3| 3| 3|            |
                                           | 1| 7| 6| 1| 9| 4| 3| 8| 9| 9| 1| 8| 4| 8| 9| 9| 1| 0| 0| 0| 9| 4| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Lymphoid                |                   3                                                      |      5  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                      4                                                   |      1  4.0|
      Cyst, Multiple                       |                      3                                                   |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     | 4                                   3                                    |      2  3.5|
      Hyperplasia, Lymphoid                |                                     3                                    |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  M  M  +  +  +  M  +  +  +  +  +  +  +  +  +|  43        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  M  M  +  +  +  I  +  +  +  +  +  +  +  +  +|  44        |
      Hyperplasia, Lobular                 |                                                                2         |      1  2.0|
      Duct, Cyst                           |                   2                    2                                 |      6  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1     |
      Fibrosis                             |                                                                          |      1  2.0|
      Ulcer                                |                                     4                                    |      1  4.0|
      Epidermis, Hyperplasia, Focal        |                                                    3                     |      1  3.0|
      Epidermis, Hyperplasia               |                                                                          |      1  2.0|
      Subcutaneous Tissue, Hemorrhage,     |                                                                          |            |
           Chronic                         |                                        2                                 |      1  2.0|
      Subcutaneous Tissue, Necrosis        |                                  4                                       |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Abdominal, Metaplasia, Osseous       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      1  4.0|
      Hemorrhage                           |    4                          3              4                           |      5  3.2|
      Hippocampus, Vacuolization           |                                                                          |            |
          Cytoplasmic                      |                                  3                                       |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 5| 6| 7| 6| 6| 6| 7| 7| 4| 4| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 8| 7| 9| 5| 2| 2| 6| 6| 2| 2| 8| 9| 1| 0| 2| 6| 4| 3| 3| 3| 2| 6| 3| 3| 3|            |
                                           | 1| 7| 6| 1| 9| 4| 3| 8| 9| 9| 1| 8| 4| 8| 9| 9| 1| 0| 0| 0| 9| 4| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |          +                                                               |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                3  3                                                      |      6  3.0|
      Edema                                |                                                                          |      1  2.0|
      Foreign Body                         |                                                                          |      2  2.0|
      Hemorrhage                           |    3                                                                     |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumen, Foreign Body                  |                                                                          |      1  2.0|
      Lumen, Fungus                        |          3                       X                                       |      7  2.3|
      Lumen, Inflammation, Suppurative     |          3                       3                                       |      8  2.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |    2                                                        2            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                        +                                 |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                             +  +                              |   7        |
      Cataract                             |          3                             3                                 |      3  3.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Retina, Degeneration                 |                                        3                                 |      4  3.3|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Pigmentation                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bacterium                            |                3                                                         |      1  3.0|
      Infarct                              |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                4                                                         |      1  4.0|
      Nephropathy, Chronic                 |    2  3  2  3        1  2  1        2  2  2     2  2  3  2  3  3  3  3  3|     41  2.2|
      Renal Tubule, Mineralization         |                                                                2         |      1  2.0|
      Renal Tubule, Pigmentation           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 9| 1| 2| 2| 4| 4| 5| 2| 2| 2| 2| 2| 2| 2| 9| 8| 1| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 7| 9| 9| 0| 5| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    112                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +        +  +  +                       +  +  +        +            |             
                                            __________________________________________________________________________|             
   Intestine Large                         | A  +  +        +  A  +                       A  +  +        +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +        +  A  +                       A  +  A        M            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +        +  A  +                       A  +  +        +            |             
      Parasite Metazoan                    |                                                    3                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +        +  A  +                       A  +  A        +            |             
      Parasite Metazoan                    |                                                             1            |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +        +  A  +                       A  +  A        +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +        +  A  +                       A  +  A        A            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +        +  A  +                       A  +  A        +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +        +  A  +                       A  +  A        A            |             
      Metaplasia, Osseous                  |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Basophilic Focus, Multiple           |          2     1        2           2  2  2                       2     2|             
      Congestion                           |                                                                          |             
      Degeneration, Cystic                 |                                                                         2|             
      Fibrosis                             |                               2                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |       3                                                                  |             
      Hepatodiaphragmatic Nodule           |       3                                   3                              |             
      Hyperplasia, Nodular                 |                      3                          3                    3   |             
      Inflammation, Granulomatous, Multiple|                                        2                                 |             
      Mixed Cell Focus, Multiple           |                                                                2         |             
      Necrosis, Focal                      |       4                                                                  |             
      Vacuolization Cytoplasmic            |       4        2     2                                2                  |             
      Bile Duct, Hyperplasia               |          2  1  1  2  3  1  2  2  2  2  2  2     2     2  2     1  2  3  3|             
      Centrilobular, Degeneration          |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +  +        +     +     +              +                              |             
      Inflammation, Chronic                |    3                 4                                                   |             
      Fat, Inflammation, Focal,            |                                                                          |             
          Granulomatous                    |                                           3                              |             
      Fat, Mineralization, Focal           |                                                                          |             
      Fat, Necrosis, Focal                 |       3        2     2     3              2                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +        +  +  +        +              A  +  A        +            |             
      Acinar Cell, Atrophy                 | 2     3              3                          3                        |             
      Acinar Cell, Hyperplasia             |                      2                                                   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +        +  +  +  +                    +  +  M        +            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +              +  +  +        +            |             
      Forestomach, Cyst                    |                                              2                           |             
      Forestomach, Edema                   |                2                                                         |             
      Forestomach, Fibrosis, Chronic       |                                                                          |             
      Forestomach, Hyperkeratosis          |                                                                          |             
      Forestomach, Inflammation, Chronic   |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 9| 1| 2| 2| 4| 4| 5| 2| 2| 2| 2| 2| 2| 2| 9| 8| 1| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 7| 9| 9| 0| 5| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    112                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Forestomach, Ulcer                   |                                                    3                     |             
      Forestomach, Epithelium, Hyperplasia |                                                    3                     |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +  +  +                 +           +            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +              +  +  +        +            |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                          +              +|             
      Hemorrhage, Focal                    |                                                                          |             
      Hyperkeratosis                       |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +        +  +  +        +              +  +  +        +            |             
      Congestion                           |                                                                          |             
      Inflammation, Chronic                | 2  2  3        3  3  3                       2  3  3        3            |             
      Mineralization                       |                   3                                                      |             
      Atrium, Congestion                   |                               4                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +        +  +  +                       +  +  +        +            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +        +  +  +                       +  +  +        +            |             
      Hypertrophy, Focal                   |                                                 2                        |             
      Vacuolization Cytoplasmic            |       4              2                             2                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +        +  +  +                       +  +  +        +            |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Focal                   |                                                 2                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +        +  +  +                       A  +  +        +            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +        +  +  +                       M  +  +        +            |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +              +     +  +  +  +        M           +|             
      Pars Distalis, Angiectasis           |                                                    4                     |             
      Pars Distalis, Cyst                  |             2                                                            |             
      Pars Distalis, Cyst, Multiple        |                                           2                              |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                2                                                         |             
      Pars Intermedia, Hemorrhage          |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +        +  +  +                       A  +  +     +  +            |             
      C-Cell, Hyperplasia                  |       2        2     2                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +        +  +  +                       +  +  +        +            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +        +  +  +                       +  +  +        +     +      |             
      Atrophy                              |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 9| 1| 2| 2| 4| 4| 5| 2| 2| 2| 2| 2| 2| 2| 9| 8| 1| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 7| 9| 9| 0| 5| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    112                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |                                                             2            |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                                 2                        |             
      Duct, Cyst                           |       3           2                                                      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +        +  +  +                       +  +  +        +            |             
      Cyst                                 |                                                 3                        |             
      Cyst, Multiple                       |                                                                          |             
      Inflammation, Chronic                |                   3                                                      |             
      Inflammation, Suppurative            | 2     2        2  3                          3     3        2            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +     +  +  +  +                       +  +  +        +            |             
      Atrophy                              |             3                                                            |             
      Dilatation                           |                   3                                                      |             
      Inflammation, Chronic                |    3                                                                     |             
      Epithelium, Hyperplasia              |    3                                                                     |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          2  2     2  4  2  2  3  2        1     3     2        1  2  3   |             
      Bilateral, Interstitial Cell,        |                                                                          |             
          Hyperplasia                      |                                                                          |             
      Interstitial Cell, Hyperplasia       |       2                                2  2     2                    2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                      +   |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +        +  +  +                       +  +  +        +            |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +                    +  +  +  +        +            |             
      Inguinal, Cyst                       |                                                                          |             
      Mediastinal, Hemorrhage              |                      3                                                   |             
      Mediastinal, Hyperplasia, Histiocytic|                      3                                                   |             
      Mediastinal, Hyperplasia, Lymphoid   |          2                                                               |             
      Mediastinal, Necrosis                |                      2                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +        M  +  +                       +  +  +        +            |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +        +  +  +                    +  A  +  +        +            |             
      Angiectasis                          |                                           3                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +|             
      Atrophy                              |                                                    3                     |             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                      3                                                   |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                      2                                                   |             
      Pigmentation                         |                                                    2                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +        +  +  +                       M  +  +        +            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 9| 1| 2| 2| 4| 4| 5| 2| 2| 2| 2| 2| 2| 2| 9| 8| 1| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 7| 9| 9| 0| 5| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    112                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +        +  +  +        +     +        +  +  +        +            |             
      Hyperplasia, Lobular                 |    2                                                                     |             
      Duct, Cyst                           |                2  2                 3        2     2                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +  +     +  +     +  +  +  +  +  +     +           +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Fibrosis                             |                                                                         3|             
      Epidermis, Hyperplasia, Focal        |       3                 3                             3                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +        +  +  +                       +  +  +        +            |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +        +  +  +                       +  +  +        +            |             
      Compression                          |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +              +        +  +  +        +            |             
      Congestion                           | 3           2                                3                           |             
      Hemorrhage                           |                   3                                                      |             
      Inflammation, Granulomatous          |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Edema                      | 3                                                                        |             
      Alveolus, Foreign Body               | 2                                                                        |             
      Alveolus, Pigmentation               |                                     2                                    |             
      Artery, Embolus Tumor, Multiple      |                                                                          |             
      Artery, Mineralization, Multiple     |                   3                                                      |             
      Lymphatic, Foreign Body              |                                              2     2                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +        +  +  +                       +  +  +        +            |             
      Lumen, Fungus                        |                2                                                         |             
      Lumen, Inflammation, Suppurative     |                2                                                         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +        +  +  +        +              +  +  +        +            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                                                  +   |             
      Cataract                             |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +        +  +  +                       +  +  +        +            |             
      Hydronephrosis                       |                   3                                         4            |             
      Hydronephrosis, Multiple             |    2                                                                     |             
      Nephropathy, Chronic                 |       2        2     3                          2  4                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 9| 1| 2| 2| 4| 4| 5| 2| 2| 2| 2| 2| 2| 2| 9| 8| 1| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 7| 9| 9| 0| 5| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    112                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Medulla, Necrosis                    |    3                                                                     |             
      Pelvis, Hemorrhage                   |    3                                                                     |             
      Pelvis, Necrosis                     |                   4                                                      |             
      Renal Tubule, Mineralization         |                   2                                                      |             
      Renal Tubule, Pigmentation           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +        +  +  +                       +  +  +        +            |             
      Inflammation, Chronic                |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 6| 7| 5| 7| 6| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 7| 8| 1| 2| 9| 0| 9| 3| 3| 8| 9| 3| 3| 3| 7| 1| 3| 3| 3| 3| 2| 3| 3| 3|            |
                                           | 5| 1| 8| 8| 9| 0| 8| 0| 0| 0| 9| 3| 0| 0| 0| 4| 8| 0| 0| 0| 3| 1| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    112                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +        +  +           +  +           +  +         |  23        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +     +  +  +        +  +        +  +  +           +  +         |  21        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +  +     +  +  +        +  +           +  +           +  +         |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +     +  +  +        +  +        +  +  +           +  +         |  21        |
      Parasite Metazoan                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +     +  +  +        +  +           +  +           +  +         |  19        |
      Parasite Metazoan                    |    2                                                                     |      2  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +     +  +  +        +  +           +  +           +  +         |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +     +  +  +        +  +           +  +           +  +         |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +     +  +  +        +  +           +  +           +  A         |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  +     +  +  +        +  +           +  +           +  +         |  17        |
      Metaplasia, Osseous                  |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |    1     2                                                               |      2  1.5|
      Basophilic Focus, Multiple           |                         2  2     2  2  2  2        2  2  2     1  1  2   |     20  1.9|
      Congestion                           |                4                                                         |      1  4.0|
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                   1                                                      |      1  1.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hepatodiaphragmatic Nodule           |                                                    X              X      |      4  3.0|
      Hyperplasia, Nodular                 |                                                 4                        |      4  3.3|
      Inflammation, Granulomatous, Multiple|                                                                          |      1  2.0|
      Mixed Cell Focus, Multiple           |             2                                                            |      2  2.0|
      Necrosis, Focal                      |                                                                          |      1  4.0|
      Vacuolization Cytoplasmic            |       4  2        1                                                     2|      8  2.4|
      Bile Duct, Hyperplasia               |             2        1  2  2     1     2  1  2  2  1  2  2     2  2  2  1|     35  1.8|
      Centrilobular, Degeneration          |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +     +                    +  +                                    |  10        |
      Inflammation, Chronic                |                                                                          |      2  3.5|
      Fat, Inflammation, Focal,            |                                                                          |            |
          Granulomatous                    |                                                                          |      1  3.0|
      Fat, Mineralization, Focal           |       2                                                                  |      1  2.0|
      Fat, Necrosis, Focal                 |       3     3                    4  3                                    |      9  2.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +  +  +        +  +           +  +           +  +         |  22        |
      Acinar Cell, Atrophy                 |                3  4                          2                           |      7  2.9|
      Acinar Cell, Hyperplasia             |                      2                                                   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +     +  +  +        +  +           +  +           +  +         |  23        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  +  +        +  +           +  +  +        +  +         |  29        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 6| 7| 5| 7| 6| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 7| 8| 1| 2| 9| 0| 9| 3| 3| 8| 9| 3| 3| 3| 7| 1| 3| 3| 3| 3| 2| 3| 3| 3|            |
                                           | 5| 1| 8| 8| 9| 0| 8| 0| 0| 0| 9| 3| 0| 0| 0| 4| 8| 0| 0| 0| 3| 1| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    112                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Forestomach, Cyst                    |                                                                          |      1  2.0|
      Forestomach, Edema                   |          3                                                  3            |      3  2.7|
      Forestomach, Fibrosis, Chronic       |       4                                                                  |      1  4.0|
      Forestomach, Hyperkeratosis          |                                                 4                        |      1  4.0|
      Forestomach, Inflammation, Chronic   |                                                 3           3            |      3  3.0|
      Forestomach, Ulcer                   |       4                                                                  |      2  3.5|
      Forestomach, Epithelium, Hyperplasia |       4                                         3                        |      3  3.3|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +           +  +  +        +  +           +     +           +         |  22        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +  +  +        +  +           +  +           +  +         |  28        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                     +  +                                 |   4        |
      Hemorrhage, Focal                    |                                     2                                    |      1  2.0|
      Hyperkeratosis                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +     +  +  +           +  +           +  +         |  25        |
      Congestion                           |                            4                                             |      1  4.0|
      Inflammation, Chronic                | 2  2     3     3  2  3        2              2  3           3  3         |     21  2.6|
      Mineralization                       |                                                                          |      1  3.0|
      Atrium, Congestion                   |                                                                          |      1  4.0|
      Atrium, Thrombosis                   |                                              3                           |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +        +  +           +  +           +  +         |  24        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +        +  +           +  +           +  +         |  24        |
      Hypertrophy, Focal                   |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |       2  2                                                               |      5  2.4|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  M  +  +  +  +  +        +  +           +  +           +  +         |  23        |
      Hemorrhage                           |                                  4                                       |      1  4.0|
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +     +  +  +        +  +           +  +           +  +         |  22        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +     +  +  +        +  +           +  +        +  +  +         |  22        |
      Hyperplasia                          |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +  +  +        +  +           +  +  +  +     +  +         |  28        |
      Pars Distalis, Angiectasis           |                                                                          |      1  4.0|
      Pars Distalis, Cyst                  |                                              1                           |      2  1.5|
      Pars Distalis, Cyst, Multiple        |                                                                          |      1  2.0|
      Pars Distalis, Hemorrhage            |                                                                4         |      1  4.0|
      Pars Distalis, Hyperplasia, Focal    |                   3                          2  2                        |      4  2.3|
      Pars Intermedia, Hemorrhage          |                                                    4                     |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 6| 7| 5| 7| 6| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 7| 8| 1| 2| 9| 0| 9| 3| 3| 8| 9| 3| 3| 3| 7| 1| 3| 3| 3| 3| 2| 3| 3| 3|            |
                                           | 5| 1| 8| 8| 9| 0| 8| 0| 0| 0| 9| 3| 0| 0| 0| 4| 8| 0| 0| 0| 3| 1| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    112                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +        +  +  +     +  +  +           +  +         |  25        |
      C-Cell, Hyperplasia                  |       2              2                                                   |      5  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +     +  +  +        +  +           +  +           +  +         |  23        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +     M  +  +     +  +  +           +  +           +  +         |  24        |
      Atrophy                              | 3     3                                                                  |      3  3.0|
      Fibrosis                             |    3                                                                     |      2  2.5|
      Hyperplasia                          |                                                 4                        |      1  4.0|
      Inflammation, Suppurative            |          4        3        3     3           2  4           2  2         |      9  2.8|
      Duct, Cyst                           |       3  3                                                  3            |      5  2.8|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +     +  +  +        +  +           +  +           +  +        +|  24        |
      Cyst                                 |                                                                          |      1  3.0|
      Cyst, Multiple                       |                                                 3                       3|      2  3.0|
      Inflammation, Chronic                |                                                 3                        |      2  3.0|
      Inflammation, Suppurative            |       2              3        3                                3         |     11  2.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +     +  +  +  +     +  +           +  +           +  +         |  25        |
      Atrophy                              |                                                                          |      1  3.0|
      Dilatation                           |                         3                                                |      2  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       4                    2        2  3     4                           |     19  2.4|
      Bilateral, Interstitial Cell,        |                                                                          |            |
          Hyperplasia                      |          2        2                                                      |      2  2.0|
      Interstitial Cell, Hyperplasia       |    2           2                                               2         |      8  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                            +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +     +  +  +        +  +           +  +           +  +         |  23        |
      Myeloid Cell, Hyperplasia            |                   4                                                      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +  +        +  +           +  +           +  +         |  25        |
      Inguinal, Cyst                       |                   3                                                      |      1  3.0|
      Mediastinal, Hemorrhage              |                                                             3            |      2  3.0|
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 6| 7| 5| 7| 6| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 7| 8| 1| 2| 9| 0| 9| 3| 3| 8| 9| 3| 3| 3| 7| 1| 3| 3| 3| 3| 2| 3| 3| 3|            |
                                           | 5| 1| 8| 8| 9| 0| 8| 0| 0| 0| 9| 3| 0| 0| 0| 4| 8| 0| 0| 0| 3| 1| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    112                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Necrosis                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +        +  +           +  +           +  +         |  21        |
      Cyst                                 |                                              2                           |      1  2.0|
      Hyperplasia, Lymphoid                |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +        +  +           +  +           +  +         |  23        |
      Angiectasis                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Atrophy                              |                                                                          |      1  3.0|
      Congestion                           |                4                                                         |      1  4.0|
      Hematopoietic Cell Proliferation     |                   3                                                      |      2  3.0|
      Hemorrhage                           |                                                             4            |      1  4.0|
      Necrosis                             |                                                             4            |      2  3.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +     +  M  +        +  +           +  +           +  +         |  20        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M     +  +  +        M  +           +  M           +  +  +      |  23        |
      Hyperplasia, Lobular                 |                                                                          |      1  2.0|
      Duct, Cyst                           |       3              3                                         2         |      8  2.4|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +        +  +  +           +  +  +  +   |  37        |
      Cyst Epithelial Inclusion            |                            3                                             |      1  3.0|
      Fibrosis                             |                                                                          |      1  3.0|
      Epidermis, Hyperplasia, Focal        |                                                                          |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +     +  +  +        +  +           +  +           +  +         |  23        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +        +  +           +  +     +     +  +         |  24        |
      Compression                          |       4              4                                                   |      2  4.0|
      Hemorrhage                           |                               2                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +           +  +  +  +     +  +         |  29        |
      Congestion                           | 3              3              4                    3  2        3         |      9  2.9|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Granulomatous          |                   2                                                      |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                    2                     |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 6| 7| 5| 7| 6| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 7| 8| 1| 2| 9| 0| 9| 3| 3| 8| 9| 3| 3| 3| 7| 1| 3| 3| 3| 3| 2| 3| 3| 3|            |
                                           | 5| 1| 8| 8| 9| 0| 8| 0| 0| 0| 9| 3| 0| 0| 0| 4| 8| 0| 0| 0| 3| 1| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    112                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolus, Edema                      |                                                                          |      1  3.0|
      Alveolus, Foreign Body               |                                                                          |      1  2.0|
      Alveolus, Pigmentation               |                         2                                                |      2  2.0|
      Artery, Embolus Tumor, Multiple      |    X                                                                     |      1     |
      Artery, Mineralization, Multiple     |                                                                          |      1  3.0|
      Lymphatic, Foreign Body              |                                                                2         |      3  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +     +  +  +        +  +           +  +           +  +         |  23        |
      Lumen, Fungus                        |    2                                                                     |      2  2.0|
      Lumen, Inflammation, Suppurative     |    2                                                                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +  +        +  +           +  +           +  +         |  24        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                +                             +         |   5        |
      Cataract                             | 4                                                              3         |      3  3.3|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +        +  +           +  +           +  +         |  23        |
      Hydronephrosis                       |                                                                          |      2  3.5|
      Hydronephrosis, Multiple             |                                                                          |      1  2.0|
      Nephropathy, Chronic                 |    2  3  3     3  2  3        2  1              2              2         |     15  2.4|
      Medulla, Necrosis                    |                                                                          |      1  3.0|
      Pelvis, Hemorrhage                   |                                                                          |      1  3.0|
      Pelvis, Necrosis                     |                                                                          |      1  4.0|
      Renal Tubule, Mineralization         |                                                                          |      1  2.0|
      Renal Tubule, Pigmentation           |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     M  +  +        +  +           +  +           +  +         |  22        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 6| 7| 7| 4| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 6| 2| 2| 2| 2| 0| 6| 2| 2| 1| 7| 9| 2| 2| 2|             
                                           | 9| 9| 9| 9| 9| 3| 7| 9| 9| 9| 5| 9| 9| 9| 9| 9| 1| 9| 9| 4| 7| 5| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    225                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Parasite Metazoan                    |    2                                2                 1                  |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                      2                                                  2|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                              4                           |             
      Basophilic Focus, Multiple           | 2        2  2  1  2  2  2  2        2                          2     2  2|             
      Clear Cell Focus                     |    1                                                                     |             
      Clear Cell Focus, Multiple           |             1                       1                                    |             
      Congestion                           |                                                                          |             
      Degeneration, Cystic                 |             1     2                             3                        |             
      Eosinophilic Focus                   |                                                    2                     |             
      Eosinophilic Focus, Multiple         |       2                                                                  |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                         3|             
      Hyperplasia, Nodular                 |                   2                    2        3           3            |             
      Inflammation, Granulomatous, Multiple|    2                    2                                               1|             
      Mixed Cell Focus                     |                         2                                                |             
      Vacuolization Cytoplasmic            | 1     2                       2  2           4           4               |             
      Bile Duct, Hyperplasia               | 2  2  2  2  2  1  2  1     2     2  2  2  1     3  2  2     4  2  2  1   |             
      Centrilobular, Degeneration          |                                                                   4      |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +        +  +  +  +  +              +                          +  +      |             
      Polyarteritis                        |             3                                                            |             
      Fat, Inflammation, Focal,            |                                                                          |             
          Granulomatous                    |                                                                3         |             
      Fat, Necrosis, Focal                 | 4        3     3     3              3                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyarteritis                        |             4     2     4                                               3|             
      Acinar Cell, Atrophy                 | 2  2  2  2                       2  3                 2              2  3|             
      Acinar Cell, Hyperplasia             |                                                       3        2         |             
      Acinar Cell, Hyperplasia, Multiple   |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 6| 7| 7| 4| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 6| 2| 2| 2| 2| 0| 6| 2| 2| 1| 7| 9| 2| 2| 2|             
                                           | 9| 9| 9| 9| 9| 3| 7| 9| 9| 9| 5| 9| 9| 9| 9| 9| 1| 9| 9| 4| 7| 5| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    225                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Forestomach, Edema                   |                                                          4               |             
      Forestomach, Inflammation, Chronic   |                                              4                           |             
      Forestomach, Polyarteritis           |                         4                                                |             
      Forestomach, Ulcer                   |                                                          3               |             
      Forestomach, Epithelium, Hyperplasia |                                              4                           |             
      Glandular, Polyarteritis             |                                                                         2|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                        3                                 |             
      Inflammation, Chronic                | 3  2  2        2  3  2  2  3  2  2  2  3  2  3  2  3  3  2  2     2  3  2|             
      Atrium, Congestion                   |                                                                3         |             
      Atrium, Fibrosis                     | 4                                                                        |             
      Atrium, Thrombosis                   |                                                                   4  4   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                            2                                             |             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia, Focal                   |                         2  2                                             |             
      Vacuolization Cytoplasmic            |          2                          2        2  2                 2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |       2                                                                  |             
      Hyperplasia, Focal, Multiple         |                                                 2                        |             
      Mineralization                       |             4                                                            |             
      Thrombosis                           |             4                                                            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                 2        4               |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hemorrhage            |                                                                4         |             
      Pars Distalis, Hyperplasia, Focal    |                      1                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                              2                           |             
      C-Cell, Hyperplasia                  | 2        3                             2  2        1  2                  |             
      Follicle, Cyst                       |       4                                                                  |             
      Follicle, Hyperplasia, Cystic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                +                                               +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 6| 7| 7| 4| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 6| 2| 2| 2| 2| 0| 6| 2| 2| 1| 7| 9| 2| 2| 2|             
                                           | 9| 9| 9| 9| 9| 3| 7| 9| 9| 9| 5| 9| 9| 9| 9| 9| 1| 9| 9| 4| 7| 5| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    225                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          3  2                                      3  3              3  2|             
      Hyperplasia                          |                      2                                                   |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis                             |                                                                          |             
      Duct, Cyst                           |                      3     2                                3            |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |          3                                                               |             
      Inflammation, Chronic                |                            3                                         2   |             
      Inflammation, Suppurative            |    1  2     2  3                 3           3  2     2  2               |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  2  3           4  4                       3                 3     3  2|             
      Mineralization                       |                                                                2         |             
      Bilateral, Atrophy                   |                                                                          |             
      Bilateral, Interstitial Cell,        |                                                                          |             
          Hyperplasia                      |                                  2                                       |             
      Interstitial Cell, Hyperplasia       | 2  2  2                                2     2  2                    2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Hyperplasia, Lymphoid      |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  2                                       |             
      Cyst, Multiple                       |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                2        3|             
      Lymphocyte, Necrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                               3                                          |             
      Lymphocyte, Necrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
      Atrophy                              | 3                                                                        |             
      Developmental Malformation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 6| 7| 7| 4| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 6| 2| 2| 2| 2| 0| 6| 2| 2| 1| 7| 9| 2| 2| 2|             
                                           | 9| 9| 9| 9| 9| 3| 7| 9| 9| 9| 5| 9| 9| 9| 9| 9| 1| 9| 9| 4| 7| 5| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    225                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lobular                 |                                                       3                  |             
      Duct, Cyst                           |             2     2                          3        2  4           3   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                   3                                3                     |             
      Epidermis, Hyperplasia, Focal        |                                              3                           |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Granulomatous                   |                                                       3                  |             
      Subcutaneous Tissue, Necrosis        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                       3                  |             
      Hemorrhage                           |                                                                3         |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 2     1                                                        2         |             
      Hemorrhage                           |                3                                3                        |             
      Alveolar Epithelium, Hyperplasia     |       2                                                                  |             
      Alveolus, Foreign Body               |                3              2                                          |             
      Artery, Embolus Tumor                |                                                                          |             
      Lymphatic, Foreign Body              |                      2                                                   |             
      Perivascular, Foreign Body           |                                                                          |             
      Subpleura, Hemorrhage                |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Fungus                        |                            2              3              3              2|             
      Lumen, Inflammation, Suppurative     |                            2              3              2              2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                            3     2                                       |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 6| 7| 7| 4| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 6| 2| 2| 2| 2| 0| 6| 2| 2| 1| 7| 9| 2| 2| 2|             
                                           | 9| 9| 9| 9| 9| 3| 7| 9| 9| 9| 5| 9| 9| 9| 9| 9| 1| 9| 9| 4| 7| 5| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    225                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                                 |             
      Cataract                             |                                        3                                 |             
      Retina, Degeneration                 |                                        3                                 |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 3  2  2  1  3  2  2  1  2  2     3  2  2  2  4  2  2  2  2        2  3  2|             
      Renal Tubule, Mineralization         |                                                                          |             
      Renal Tubule, Pigmentation           |                                                 3           3     3      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 6| 3| 3| 3| 2| 6| 0| 3| 3| 8| 3| 3| 3| 3| 5| 6| 6| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 8| 0| 0| 0| 9| 7| 4| 0| 0| 1| 0| 0| 0| 0| 0| 3| 9| 0| 0| 0| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    225                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Focal                      |                               3                                          |      1  3.0|
      Parasite Metazoan                    |       2  2                          1                             2     2|      8  1.8|
      Ulcer                                |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                  1                                       |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |       3                          3        3                              |      5  2.6|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |          2              1     2                             1            |      5  2.0|
      Basophilic Focus, Multiple           |       2                    2     2        1        2     2               |     18  1.9|
      Clear Cell Focus                     |       2                                                                  |      2  1.5|
      Clear Cell Focus, Multiple           |                         2                                                |      3  1.3|
      Congestion                           |                      3                                                   |      1  3.0|
      Degeneration, Cystic                 |                                           2                              |      4  2.0|
      Eosinophilic Focus                   |                                                                          |      1  2.0|
      Eosinophilic Focus, Multiple         |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                   2                                                      |      1  2.0|
      Hepatodiaphragmatic Nodule           |    3     2                             2        3                    2  3|      7  2.6|
      Hyperplasia, Nodular                 |    3        2                                                            |      6  2.5|
      Inflammation, Granulomatous, Multiple|                                                                          |      3  1.7|
      Mixed Cell Focus                     |          2                       1                                   2   |      4  1.8|
      Vacuolization Cytoplasmic            |                2                 2        1        2                 2   |     11  2.2|
      Bile Duct, Hyperplasia               |       2  2  2     1  2  2  1     2  2  1  2        2  1  2  1     2  2  2|     38  1.8|
      Centrilobular, Degeneration          |                               2              2                           |      3  2.7|
      Centrilobular, Necrosis              |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +  +        +  +     +        +              +     +                 +|  19        |
      Polyarteritis                        |                                                                          |      1  3.0|
      Fat, Inflammation, Focal,            |                                                                          |            |
          Granulomatous                    |                                  3                                       |      2  3.0|
      Fat, Necrosis, Focal                 | 2  3  2           3     2                       3     2                 2|     13  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Polyarteritis                        |                      3                                   3               |      6  3.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 6| 3| 3| 3| 2| 6| 0| 3| 3| 8| 3| 3| 3| 3| 5| 6| 6| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 8| 0| 0| 0| 9| 7| 4| 0| 0| 1| 0| 0| 0| 0| 0| 3| 9| 0| 0| 0| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    225                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Acinar Cell, Atrophy                 |    3  2  2  3           2           3  2  2  2        2        2     3   |     21  2.3|
      Acinar Cell, Hyperplasia             |                                                             2           3|      4  2.5|
      Acinar Cell, Hyperplasia, Multiple   |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Forestomach, Edema                   |                                                                          |      1  4.0|
      Forestomach, Inflammation, Chronic   |                                                                          |      1  4.0|
      Forestomach, Polyarteritis           |                                                                          |      1  4.0|
      Forestomach, Ulcer                   |                                                                          |      1  3.0|
      Forestomach, Epithelium, Hyperplasia |                                        2                                 |      2  3.0|
      Glandular, Polyarteritis             |                      3                                                   |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Focal                      |                                                                          |      1  3.0|
      Inflammation, Chronic                |    2  2  2  3  2     2  2  2  3  3  3  2  2  3  3  3  2  3  3     2     2|     43  2.4|
      Atrium, Congestion                   |                      4  3  3                                             |      4  3.3|
      Atrium, Fibrosis                     |                                                                          |      1  4.0|
      Atrium, Thrombosis                   |                   4                 2                                    |      4  3.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Accessory Adrenal Cortical Nodule    |                                                                      2   |      2  2.0|
      Degeneration, Cystic                 |       2           4           2                                2         |      4  2.5|
      Hyperplasia, Focal                   |                                                          2               |      3  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      5  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Hyperplasia, Focal, Multiple         |                               3                                          |      2  2.5|
      Mineralization                       |                                                                          |      1  4.0|
      Thrombosis                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |                                                                          |      2  3.0|
      Pars Distalis, Cyst                  |       2                                                                  |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 6| 3| 3| 3| 2| 6| 0| 3| 3| 8| 3| 3| 3| 3| 5| 6| 6| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 8| 0| 0| 0| 9| 7| 4| 0| 0| 1| 0| 0| 0| 0| 0| 3| 9| 0| 0| 0| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    225                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Hemorrhage            |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia, Focal    | 1        3                                                               |      3  1.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                                                          |      1  2.0|
      C-Cell, Hyperplasia                  |          2        2  2        3                 2        2           2   |     13  2.1|
      Follicle, Cyst                       |                                                                          |      1  4.0|
      Follicle, Hyperplasia, Cystic        | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 2        3     3                 3                          3  2     3   |     13  2.7|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic                |                               3                                          |      1  3.0|
      Inflammation, Suppurative            |                                     2              3                     |      2  2.5|
      Necrosis                             |                               4                                          |      1  4.0|
      Duct, Cyst                           |    3                          4     3     2                              |      7  2.9|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Fibrosis                             |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      2  2.5|
      Inflammation, Suppurative            | 4  3  2                    3  2                    2  2           3      |     17  2.4|
      Epithelium, Hyperplasia              |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          2  3  4  4  1     4           2              2  3  1  2     2  3|     22  2.7|
      Mineralization                       |                                                                          |      1  2.0|
      Bilateral, Atrophy                   |       3                                                                  |      1  3.0|
      Bilateral, Interstitial Cell,        |                                                                          |            |
          Hyperplasia                      |                                              2                           |      2  2.0|
      Interstitial Cell, Hyperplasia       |    2                                      2        2  2           2  2  2|     14  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myeloid Cell, Hyperplasia            |                   4                                                      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 6| 3| 3| 3| 2| 6| 0| 3| 3| 8| 3| 3| 3| 3| 5| 6| 6| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 8| 0| 0| 0| 9| 7| 4| 0| 0| 1| 0| 0| 0| 0| 0| 3| 9| 0| 0| 0| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    225                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Axillary, Hyperplasia, Lymphoid      |                                                             3            |      1  3.0|
      Inguinal, Hyperplasia, Lymphoid      |                   2                                                      |      1  2.0|
      Mediastinal, Pigmentation            |                4                                                         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1  2.0|
      Cyst, Multiple                       |                                        3                 4               |      2  3.5|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
      Lymphocyte, Necrosis                 |    4                                                                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Lymphocyte, Necrosis                 |    4                                                                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Focal                       |                                  3                                       |      1  3.0|
      Atrophy                              |                                                                          |      1  3.0|
      Developmental Malformation           |          2                                                               |      1  2.0|
      Hematopoietic Cell Proliferation     |                   4                                                      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Lobular                 |                                                                          |      1  3.0|
      Duct, Cyst                           |                      3     3                    2                 2      |     10  2.6|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                      3                                            3      |      4  3.0|
      Epidermis, Hyperplasia, Focal        |                                                                          |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Granulomatous                   |                                                                          |      1  3.0|
      Subcutaneous Tissue, Necrosis        |                                                    4                     |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +              +                                               +         |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +                                                                        |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05002-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        GAMMA-BUTYROLACTONE                                    Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 07:03:43  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 6| 3| 3| 3| 2| 6| 0| 3| 3| 8| 3| 3| 3| 3| 5| 6| 6| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 8| 0| 0| 0| 9| 7| 4| 0| 0| 1| 0| 0| 0| 0| 0| 3| 9| 0| 0| 0| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    225                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                      3                                                  2|      5  2.0|
      Hemorrhage                           |                                                                          |      2  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Alveolus, Foreign Body               |                                                                          |      2  2.5|
      Artery, Embolus Tumor                |                                                                   X      |      1     |
      Lymphatic, Foreign Body              |       2              2                                                   |      3  2.0|
      Perivascular, Foreign Body           |                            2                                             |      1  2.0|
      Subpleura, Hemorrhage                |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lumen, Fungus                        |    3           2              2        3                 3               |      9  2.6|
      Lumen, Inflammation, Suppurative     |                2              2        3                 3               |      8  2.4|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                            3                                             |      3  2.7|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                   +                                                      |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +  +                                                                  |   3        |
      Cataract                             |    3  3                                                                  |      3  3.0|
      Retina, Degeneration                 |    3  3                                                                  |      3  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 2  2  2  2  1     2  3  2  3  2  2  2  2  2  2  2  1  2  2  2  2  2  2  4|     46  2.1|
      Renal Tubule, Mineralization         |                               1     1                                    |      2  1.0|
      Renal Tubule, Pigmentation           |                4                                                         |      4  3.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
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