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TDMS Study 05004-04 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                      FURAN                                         DATE: 09/03/94       
EXPERIMENT: 05004 TEST: 04                                                                                     TIME: 03:04:04       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1CP9565101          ROUTE: GAVAGE                                                                      NTP C#: 56202        
PATHOLOGIST: D. FARNELL                      S. EUSTIS                                                         CAS: 110-00-9        
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08    
LAB: Southern Research Inst                                      FURAN                                         DATE: 09/03/94      
EXPERIMENT: 05004 TEST: 04                                                                                     TIME: 03:04:04      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: NO1CP9565101          ROUTE: GAVAGE                                                                      NTP C#: 56202       
PATHOLOGIST: D. FARNELL                      S. EUSTIS                                                         CAS: 110-00-9       
 
 
 
 
 
                                                    MICE(B6C3F1)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
 
 
                                                    ----------------
 
                                                    Adrenal Gland
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Gallbladder
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                      FURAN                                         DATE: 09/03/94       
EXPERIMENT: 05004 TEST: 04                                                                                     TIME: 03:04:04       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1CP9565101          ROUTE: GAVAGE                                                                      NTP C#: 56202        
PATHOLOGIST: D. FARNELL                      S. EUSTIS                                                         CAS: 110-00-9        
 
 
 
 
 
                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                             IN THE ANALYSIS OF THE STUDY OF FURAN
 
              ====================================================================================================
 
                                                           MALE MICE
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Adrenal Cortex                Adenoma
                             Adrenal Medulla               Pheochromocytoma Benign
                             Liver                         Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma
                                                           Hepatocellular Carcinoma or Hepatoblastoma
                                                           Hepatocellular Carcinoma or Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
                             Lung                          Alveolar/Bronchiolar Adenoma
                                                           Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
                             Skin: Subcutaneous Tissue     Fibroma
                                                           Neurofibrosarcoma, Fibrosarcoma, or Sarcoma
                             Spleen                        Hemangiosarcoma
                             Stomach, Forestomach          Squamous Cell Papilloma
                             All Organs                    Malignant Lymphoma And Histiocytic Sarcoma
                                                           Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
                                                            NOS, or Undifferentiated Cell Type
                                                           Benign Tumors
                                                           Malignant Tumors
                                                           Malignant and Benign Tumors
 
              ====================================================================================================
 
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                      FURAN                                         DATE: 09/03/94       
EXPERIMENT: 05004 TEST: 04                                                                                     TIME: 03:04:04       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1CP9565101          ROUTE: GAVAGE                                                                      NTP C#: 56202        
PATHOLOGIST: D. FARNELL                      S. EUSTIS                                                         CAS: 110-00-9        
 
 
 
 
 
                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                             IN THE ANALYSIS OF THE STUDY OF FURAN
 
              ====================================================================================================
 
                                                           FEMALE MICE
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Adrenal Medulla               Pheochromocytoma Benign
                             Liver                         Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma
                                                           Hepatocellular Carcinoma or Hepatoblastoma
                                                           Hepatocellular Carcinoma or Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
                             Mammary Gland                 Carcinoma
                             Pituitary Gland: Pars Distalis or Unspecified Site
                                                           Adenoma
                                                           Carcinoma or Adenoma
                             Stomach, Forestomach          Squamous Cell Papilloma
                             All Organs                    Malignant Lymphoma And Histiocytic Sarcoma
                                                           Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
                                                            NOS, or Undifferentiated Cell Type
                                                           Benign Tumors
                                                           Malignant Tumors
                                                           Malignant and Benign Tumors
 
              ====================================================================================================
         DATE: 09/03/94                     EXPERIMENT: 05004 TEST: 04                                                 PAGE   1
                                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         8. MG/KG        15.           |      VEHICLE         8. MG/KG        15.           |
|                       |      CONTROL                         MG/KG         |      CONTROL                         MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     6/50 (12%)      3/50 (6%)       0/50 (0%)      |     0/50 (0%)       0/50 (0%)       1/50 (2%)      |
|ADJUSTED (b)           |     17.0%           13.2%            0.0%          |      0.0%            0.0%            4.8%          |
|TERMINAL (d)           |     5/33 (15%)      1/17 (6%)       0/16 (0%)      |     0/29 (0%)       0/25 (0%)       0/2 (0%)       |
|FIRST INCIDENCE (DAYS) |      550             719             ---           |      ---             ---             701           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.068N        P=0.540N        P=0.072N       |     P=0.221           (e)           P=0.398        |
|INCIDENTAL TUMOR       |     P=0.022N*       P=0.338N        P=0.033N*      |     P=0.413           (e)           P=0.662        |
|LOGISTIC REGRESSION    |     P=0.015N*       P=0.308N        P=0.018N*      |     P=0.254           (e)           P=0.440        |
|COCHRAN-ARMITAGE       |     P=0.011N*                                      |     P=0.293                                        |
|FISHER EXACT           |                     P=0.243N        P=0.013N*      |                       (e)           P=0.500        |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/49 (2%)       6/50 (12%)     10/50 (20%)     |     2/50 (4%)       1/50 (2%)       6/50 (12%)     |
|ADJUSTED (b)           |      2.6%           24.6%           32.9%          |      5.9%            4.0%           47.1%          |
|TERMINAL (d)           |     0/33 (0%)       2/17 (12%)      2/16 (13%)     |     1/29 (3%)       1/25 (4%)       0/2 (0%)       |
|FIRST INCIDENCE (DAYS) |      723             701             423           |      680             736 (T)         642           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P<0.001 **      P=0.016 *       P=0.001 **     |     P=0.003 **      P=0.537N        P=0.003 **     |
|INCIDENTAL TUMOR       |     P=0.012 *       P=0.091         P=0.026 *      |     P=0.146         P=0.501N        P=0.324        |
|LOGISTIC REGRESSION    |     P=0.004 **      P=0.032 *       P=0.009 **     |     P=0.028 *       P=0.499N        P=0.040 *      |
|COCHRAN-ARMITAGE       |     P=0.004 **                                     |     P=0.081                                        |
|FISHER EXACT           |                     P=0.059         P=0.004 **     |                     P=0.500N        P=0.134        |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05004 TEST: 04                                                 PAGE   2
                                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         8. MG/KG        15.           |      VEHICLE         8. MG/KG        15.           |
|                       |      CONTROL                         MG/KG         |      CONTROL                         MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       0/50 (0%)       1/50 (2%)      |     1/50 (2%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      4.7%            0.0%            2.3%          |      3.4%            0.0%            0.0%          |
|TERMINAL (d)           |     0/33 (0%)       0/17 (0%)       0/16 (0%)      |     1/29 (3%)       0/25 (0%)       0/2 (0%)       |
|FIRST INCIDENCE (DAYS) |      660             ---             610           |      736 (T)         ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.397N        P=0.290N        P=0.550N       |     P=0.490N        P=0.530N        P=0.962N       |
|INCIDENTAL TUMOR       |     P=0.145N        P=0.133N        P=0.205N       |     P=0.490N        P=0.530N        P=0.962N       |
|LOGISTIC REGRESSION    |     P=0.340N        P=0.238N        P=0.442N       |     P=0.490N        P=0.530N        P=0.962N       |
|COCHRAN-ARMITAGE       |     P=0.352N                                       |     P=0.274N                                       |
|FISHER EXACT           |                     P=0.247N        P=0.500N       |                     P=0.500N        P=0.500N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/50 (6%)       4/50 (8%)       0/50 (0%)      |     2/50 (4%)       4/50 (8%)       2/50 (4%)      |
|ADJUSTED (b)           |      7.9%           15.2%            0.0%          |      6.9%           14.2%           13.9%          |
|TERMINAL (d)           |     1/33 (3%)       1/17 (6%)       0/16 (0%)      |     2/29 (7%)       3/25 (12%)      0/2 (0%)       |
|FIRST INCIDENCE (DAYS) |      715             663             ---           |      736 (T)         673             685           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.273N        P=0.308         P=0.193N       |     P=0.083         P=0.281         P=0.150        |
|INCIDENTAL TUMOR       |     P=0.085N        P=0.600         P=0.084N       |     P=0.273         P=0.302         P=0.507        |
|LOGISTIC REGRESSION    |     P=0.159N        P=0.429         P=0.146N       |     P=0.357         P=0.332         P=0.482        |
|COCHRAN-ARMITAGE       |     P=0.132N                                       |     P=0.578                                        |
|FISHER EXACT           |                     P=0.500         P=0.121N       |                     P=0.339         P=0.691N       |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05004 TEST: 04                                                 PAGE   3
                                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         8. MG/KG        15.           |      VEHICLE         8. MG/KG        15.           |
|                       |      CONTROL                         MG/KG         |      CONTROL                         MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/50 (6%)       5/50 (10%)      0/50 (0%)      |     2/50 (4%)       4/50 (8%)       2/50 (4%)      |
|ADJUSTED (b)           |      7.9%           17.2%            0.0%          |      6.9%           14.2%           13.9%          |
|TERMINAL (d)           |     1/33 (3%)       1/17 (6%)       0/16 (0%)      |     2/29 (7%)       3/25 (12%)      0/2 (0%)       |
|FIRST INCIDENCE (DAYS) |      715             556             ---           |      736 (T)         673             685           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.291N        P=0.200         P=0.193N       |     P=0.083         P=0.281         P=0.150        |
|INCIDENTAL TUMOR       |     P=0.069N        P=0.526         P=0.084N       |     P=0.273         P=0.302         P=0.507        |
|LOGISTIC REGRESSION    |     P=0.159N        P=0.329         P=0.146N       |     P=0.357         P=0.332         P=0.482        |
|COCHRAN-ARMITAGE       |     P=0.152N                                       |     P=0.578                                        |
|FISHER EXACT           |                     P=0.357         P=0.121N       |                     P=0.339         P=0.691N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       4/50 (8%)       2/50 (4%)      |     0/50 (0%)       0/50 (0%)       1/50 (2%)      |
|ADJUSTED (b)           |      5.5%           15.2%            8.4%          |      0.0%            0.0%            7.1%          |
|TERMINAL (d)           |     1/33 (3%)       0/17 (0%)       1/16 (6%)      |     0/29 (0%)       0/25 (0%)       0/2 (0%)       |
|FIRST INCIDENCE (DAYS) |      715             704             610           |      ---             ---             717           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.372         P=0.188         P=0.539        |     P=0.180           (e)           P=0.329        |
|INCIDENTAL TUMOR       |     P=0.460N        P=0.487         P=0.659N       |     P=0.413           (e)           P=0.662        |
|LOGISTIC REGRESSION    |     P=0.536         P=0.251         P=0.698        |     P=0.220           (e)           P=0.390        |
|COCHRAN-ARMITAGE       |     P=0.578                                        |     P=0.293                                        |
|FISHER EXACT           |                     P=0.339         P=0.691N       |                       (e)           P=0.500        |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05004 TEST: 04                                                 PAGE   4
                                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         8. MG/KG        15.           |      VEHICLE         8. MG/KG        15.           |
|                       |      CONTROL                         MG/KG         |      CONTROL                         MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    20/50 (40%)     33/50 (66%)     42/50 (84%)     |     5/50 (10%)     31/50 (62%)     48/50 (96%)     |
|ADJUSTED (b)           |     51.7%           86.4%          100.0%          |     17.2%           78.5%          100.0%          |
|TERMINAL (d)           |    15/33 (45%)     12/17 (71%)     16/16 (100%)    |     5/29 (17%)     17/25 (68%)      2/2 (100%)     |
|FIRST INCIDENCE (DAYS) |      550             444             498           |      736 (T)         446             360           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P<0.001 **      P<0.001 **      P<0.001 **     |     P<0.001 **      P<0.001 **      P<0.001 **     |
|INCIDENTAL TUMOR       |     P<0.001 **      P=0.002 **      P<0.001 **     |     P<0.001 **      P<0.001 **      P<0.001 **     |
|LOGISTIC REGRESSION    |     P<0.001 **      P=0.001 **      P<0.001 **     |     P<0.001 **      P<0.001 **      P<0.001 **     |
|COCHRAN-ARMITAGE       |     P<0.001 **                                     |     P<0.001 **                                     |
|FISHER EXACT           |                     P=0.008 **      P<0.001 **     |                     P<0.001 **      P<0.001 **     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     7/50 (14%)     33/50 (66%)     34/50 (68%)     |     2/50 (4%)       7/50 (14%)     27/50 (54%)     |
|ADJUSTED (b)           |     17.1%           77.4%           77.9%          |      5.8%           21.8%           94.7%          |
|TERMINAL (d)           |     0/33 (0%)       8/17 (47%)      7/16 (44%)     |     1/29 (3%)       3/25 (12%)      1/2 (50%)      |
|FIRST INCIDENCE (DAYS) |      514             444             423           |      646             499             475           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P<0.001 **      P<0.001 **      P<0.001 **     |     P<0.001 **      P=0.070         P<0.001 **     |
|INCIDENTAL TUMOR       |     P<0.001 **      P<0.001 **      P<0.001 **     |     P<0.001 **      P=0.082         P<0.001 **     |
|LOGISTIC REGRESSION    |     P<0.001 **      P<0.001 **      P<0.001 **     |     P<0.001 **      P=0.081         P<0.001 **     |
|COCHRAN-ARMITAGE       |     P<0.001 **                                     |     P<0.001 **                                     |
|FISHER EXACT           |                     P<0.001 **      P<0.001 **     |                     P=0.080         P<0.001 **     |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05004 TEST: 04                                                 PAGE   5
                                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         8. MG/KG        15.           |      VEHICLE         8. MG/KG        15.           |
|                       |      CONTROL                         MG/KG         |      CONTROL                         MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     7/50 (14%)     33/50 (66%)     34/50 (68%)     |     2/50 (4%)       7/50 (14%)     27/50 (54%)     |
|ADJUSTED (b)           |     17.1%           77.4%           77.9%          |      5.8%           21.8%           94.7%          |
|TERMINAL (d)           |     0/33 (0%)       8/17 (47%)      7/16 (44%)     |     1/29 (3%)       3/25 (12%)      1/2 (50%)      |
|FIRST INCIDENCE (DAYS) |      514             444             423           |      646             499             475           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P<0.001 **      P<0.001 **      P<0.001 **     |     P<0.001 **      P=0.070         P<0.001 **     |
|INCIDENTAL TUMOR       |     P<0.001 **      P<0.001 **      P<0.001 **     |     P<0.001 **      P=0.082         P<0.001 **     |
|LOGISTIC REGRESSION    |     P<0.001 **      P<0.001 **      P<0.001 **     |     P<0.001 **      P=0.081         P<0.001 **     |
|COCHRAN-ARMITAGE       |     P<0.001 **                                     |     P<0.001 **                                     |
|FISHER EXACT           |                     P<0.001 **      P<0.001 **     |                     P=0.080         P<0.001 **     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    26/50 (52%)     44/50 (88%)     50/50 (100%)    |     7/50 (14%)     35/50 (70%)     50/50 (100%)    |
|ADJUSTED (b)           |     58.9%           97.8%          100.0%          |     22.6%           82.7%          100.0%          |
|TERMINAL (d)           |    15/33 (45%)     16/17 (94%)     16/16 (100%)    |     6/29 (21%)     18/25 (72%)      2/2 (100%)     |
|FIRST INCIDENCE (DAYS) |      514             444             423           |      646             446             360           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P<0.001 **      P<0.001 **      P<0.001 **     |     P<0.001 **      P<0.001 **      P<0.001 **     |
|INCIDENTAL TUMOR       |     P<0.001 **      P<0.001 **      P<0.001 **     |     P<0.001 **      P<0.001 **      P<0.001 **     |
|LOGISTIC REGRESSION    |     P<0.001 **      P<0.001 **      P<0.001 **     |     P<0.001 **      P<0.001 **      P<0.001 **     |
|COCHRAN-ARMITAGE       |     P<0.001 **                                     |     P<0.001 **                                     |
|FISHER EXACT           |                     P<0.001 **      P<0.001 **     |                     P<0.001 **      P<0.001 **     |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05004 TEST: 04                                                 PAGE   6
                                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         8. MG/KG        15.           |      VEHICLE         8. MG/KG        15.           |
|                       |      CONTROL                         MG/KG         |      CONTROL                         MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    26/50 (52%)     44/50 (88%)     50/50 (100%)    |     7/50 (14%)     35/50 (70%)     50/50 (100%)    |
|ADJUSTED (b)           |     58.9%           97.8%          100.0%          |     22.6%           82.7%          100.0%          |
|TERMINAL (d)           |    15/33 (45%)     16/17 (94%)     16/16 (100%)    |     6/29 (21%)     18/25 (72%)      2/2 (100%)     |
|FIRST INCIDENCE (DAYS) |      514             444             423           |      646             446             360           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P<0.001 **      P<0.001 **      P<0.001 **     |     P<0.001 **      P<0.001 **      P<0.001 **     |
|INCIDENTAL TUMOR       |     P<0.001 **      P<0.001 **      P<0.001 **     |     P<0.001 **      P<0.001 **      P<0.001 **     |
|LOGISTIC REGRESSION    |     P<0.001 **      P<0.001 **      P<0.001 **     |     P<0.001 **      P<0.001 **      P<0.001 **     |
|COCHRAN-ARMITAGE       |     P<0.001 **                                     |     P<0.001 **                                     |
|FISHER EXACT           |                     P<0.001 **      P<0.001 **     |                     P<0.001 **      P<0.001 **     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocholangiocarcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       2/50 (4%)       0/50 (0%)      |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            5.6%            0.0%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/33 (0%)       0/17 (0%)       0/16 (0%)      |     0/29 (0%)       0/25 (0%)       0/2 (0%)       |
|FIRST INCIDENCE (DAYS) |      ---             557             ---           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.613         P=0.204           (e)          |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.505N        P=0.439           (e)          |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.669         P=0.261           (e)          |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.650                                        |       (e)                                          |
|FISHER EXACT           |                     P=0.247           (e)          |                       (e)             (e)          |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05004 TEST: 04                                                 PAGE   7
                                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         8. MG/KG        15.           |      VEHICLE         8. MG/KG        15.           |
|                       |      CONTROL                         MG/KG         |      CONTROL                         MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     9/50 (18%)      7/50 (14%)     16/50 (32%)     |     3/50 (6%)       4/50 (8%)       3/50 (6%)      |
|ADJUSTED (b)           |     23.8%           30.3%           58.4%          |      8.7%           13.6%           37.0%          |
|TERMINAL (d)           |     6/33 (18%)      4/17 (24%)      6/16 (38%)     |     1/29 (3%)       2/25 (8%)       0/2 (0%)       |
|FIRST INCIDENCE (DAYS) |      638             556             577           |      690             673             668           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.003 **      P=0.410         P=0.004 **     |     P=0.104         P=0.454         P=0.159        |
|INCIDENTAL TUMOR       |     P=0.056         P=0.475N        P=0.097        |     P=0.520N        P=0.555         P=0.490N       |
|LOGISTIC REGRESSION    |     P=0.041 *       P=0.478N        P=0.044 *      |     P=0.391         P=0.502         P=0.474        |
|COCHRAN-ARMITAGE       |     P=0.065                                        |     P=0.578                                        |
|FISHER EXACT           |                     P=0.393N        P=0.083        |                     P=0.500         P=0.661N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     4/50 (8%)       3/50 (6%)       0/50 (0%)      |     2/50 (4%)       2/50 (4%)       1/50 (2%)      |
|ADJUSTED (b)           |     11.0%           11.6%            0.0%          |      6.0%            4.9%            2.7%          |
|TERMINAL (d)           |     3/33 (9%)       1/17 (6%)       0/16 (0%)      |     1/29 (3%)       0/25 (0%)       0/2 (0%)       |
|FIRST INCIDENCE (DAYS) |      542             584             ---           |      690             627             586           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.151N        P=0.571         P=0.148N       |     P=0.612N        P=0.685         P=0.704        |
|INCIDENTAL TUMOR       |     P=0.083N        P=0.577N        P=0.173N       |     P=0.223N        P=0.635N        P=0.496N       |
|LOGISTIC REGRESSION    |     P=0.052N        P=0.507N        P=0.053N       |     P=0.388N        P=0.695         P=0.511N       |
|COCHRAN-ARMITAGE       |     P=0.053N                                       |     P=0.402N                                       |
|FISHER EXACT           |                     P=0.500N        P=0.059N       |                     P=0.691N        P=0.500N       |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05004 TEST: 04                                                 PAGE   8
                                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         8. MG/KG        15.           |      VEHICLE         8. MG/KG        15.           |
|                       |      CONTROL                         MG/KG         |      CONTROL                         MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    13/50 (26%)     10/50 (20%)     16/50 (32%)     |     4/50 (8%)       6/50 (12%)      4/50 (8%)      |
|ADJUSTED (b)           |     33.7%           39.5%           58.4%          |     11.9%           17.9%           38.7%          |
|TERMINAL (d)           |     9/33 (27%)      5/17 (29%)      6/16 (38%)     |     2/29 (7%)       2/25 (8%)       0/2 (0%)       |
|FIRST INCIDENCE (DAYS) |      542             556             577           |      690             627             586           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.028 *       P=0.373         P=0.029 *      |     P=0.089         P=0.336         P=0.099        |
|INCIDENTAL TUMOR       |     P=0.250         P=0.425N        P=0.282        |     P=0.441N        P=0.437         P=0.557N       |
|LOGISTIC REGRESSION    |     P=0.241         P=0.387N        P=0.248        |     P=0.445         P=0.372         P=0.507        |
|COCHRAN-ARMITAGE       |     P=0.303                                        |     P=0.561                                        |
|FISHER EXACT           |                     P=0.318N        P=0.330        |                     P=0.370         P=0.643N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |     3/50 (6%)       1/50 (2%)       3/50 (6%)      |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |     10.3%            2.9%           28.3%          |
|TERMINAL (d)           |     0/33 (0%)       0/17 (0%)       0/16 (0%)      |     3/29 (10%)      0/25 (0%)       0/2 (0%)       |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      736 (T)         702             685           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.168         P=0.346N        P=0.046 *      |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.560         P=0.319N        P=0.397        |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.415         P=0.310N        P=0.342        |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.583N                                       |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.309N        P=0.661N       |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05004 TEST: 04                                                 PAGE   9
                                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         8. MG/KG        15.           |      VEHICLE         8. MG/KG        15.           |
|                       |      CONTROL                         MG/KG         |      CONTROL                         MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/44 (0%)       1/48 (2%)      |    25/49 (51%)     19/47 (40%)      9/46 (20%)     |
|ADJUSTED (b)           |      0.0%            0.0%            2.5%          |     68.7%           58.2%           35.9%          |
|TERMINAL (d)           |     0/33 (0%)       0/17 (0%)       0/16 (0%)      |    18/29 (62%)     11/24 (46%)      0/2 (0%)       |
|FIRST INCIDENCE (DAYS) |      ---             ---             641           |      557             646             549           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.280           (e)           P=0.477        |     P=0.284         P=0.357N        P=0.215        |
|INCIDENTAL TUMOR       |     P=0.514           (e)           P=0.814        |     P=0.017N*       P=0.225N        P=0.044N*      |
|LOGISTIC REGRESSION    |     P=0.292           (e)           P=0.541        |     P=0.009N**      P=0.204N        P=0.008N**     |
|COCHRAN-ARMITAGE       |     P=0.290                                        |     P=0.001N**                                     |
|FISHER EXACT           |                       (e)           P=0.490        |                     P=0.201N        P=0.001N**     |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/44 (0%)       1/48 (2%)      |    26/49 (53%)     19/47 (40%)      9/46 (20%)     |
|ADJUSTED (b)           |      0.0%            0.0%            2.5%          |     71.5%           58.2%           35.9%          |
|TERMINAL (d)           |     0/33 (0%)       0/17 (0%)       0/16 (0%)      |    19/29 (66%)     11/24 (46%)      0/2 (0%)       |
|FIRST INCIDENCE (DAYS) |      ---             ---             641           |      557             646             549           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.280           (e)           P=0.477        |     P=0.328         P=0.295N        P=0.225        |
|INCIDENTAL TUMOR       |     P=0.514           (e)           P=0.814        |     P=0.012N*       P=0.170N        P=0.040N*      |
|LOGISTIC REGRESSION    |     P=0.292           (e)           P=0.541        |     P=0.005N**      P=0.149N        P=0.005N**     |
|COCHRAN-ARMITAGE       |     P=0.290                                        |     P<0.001N**                                     |
|FISHER EXACT           |                       (e)           P=0.490        |                     P=0.150N        P<0.001N**     |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05004 TEST: 04                                                 PAGE  10
                                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         8. MG/KG        15.           |      VEHICLE         8. MG/KG        15.           |
|                       |      CONTROL                         MG/KG         |      CONTROL                         MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/50 (6%)       0/50 (0%)       0/50 (0%)      |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      9.1%            0.0%            0.0%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     3/33 (9%)       0/17 (0%)       0/16 (0%)      |     0/29 (0%)       0/25 (0%)       0/2 (0%)       |
|FIRST INCIDENCE (DAYS) |      736 (T)         ---             ---           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.108N        P=0.259N        P=0.273N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.108N        P=0.259N        P=0.273N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.108N        P=0.259N        P=0.273N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.035N*                                      |       (e)                                          |
|FISHER EXACT           |                     P=0.121N        P=0.121N       |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       3/50 (6%)       1/50 (2%)      |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%           11.4%            3.6%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/33 (0%)       0/17 (0%)       0/16 (0%)      |     0/29 (0%)       0/25 (0%)       0/2 (0%)       |
|FIRST INCIDENCE (DAYS) |      ---             698             722           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.245         P=0.071         P=0.439        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.546         P=0.220         P=0.621        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.315         P=0.092         P=0.468        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.360                                        |       (e)                                          |
|FISHER EXACT           |                     P=0.121         P=0.500        |                       (e)             (e)          |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05004 TEST: 04                                                 PAGE  11
                                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         8. MG/KG        15.           |      VEHICLE         8. MG/KG        15.           |
|                       |      CONTROL                         MG/KG         |      CONTROL                         MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Neurofibroma or Fibroma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/50 (6%)       1/50 (2%)       0/50 (0%)      |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      9.1%            5.9%            0.0%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     3/33 (9%)       1/17 (6%)       0/16 (0%)      |     0/29 (0%)       0/25 (0%)       0/2 (0%)       |
|FIRST INCIDENCE (DAYS) |      736 (T)         736 (T)         ---           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.187N        P=0.561N        P=0.273N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.187N        P=0.561N        P=0.273N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.187N        P=0.561N        P=0.273N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.061N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.309N        P=0.121N       |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Neurofibrosarcoma, Fibrosarcoma, Sarcoma,                                                                                   |
|     Neurofibroma, or Fibroma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     4/50 (8%)       6/50 (12%)      3/50 (6%)      |     0/50 (0%)       2/50 (4%)       0/50 (0%)      |
|ADJUSTED (b)           |     11.2%           23.8%            8.4%          |      0.0%            5.4%            0.0%          |
|TERMINAL (d)           |     3/33 (9%)       2/17 (12%)      0/16 (0%)      |     0/29 (0%)       0/25 (0%)       0/2 (0%)       |
|FIRST INCIDENCE (DAYS) |      697             600             556           |      ---             638             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.419         P=0.138         P=0.597        |     P=0.538         P=0.238           (e)          |
|INCIDENTAL TUMOR       |     P=0.353N        P=0.358         P=0.415N       |     P=0.493N        P=0.297           (e)          |
|LOGISTIC REGRESSION    |     P=0.481N        P=0.287         P=0.502N       |     P=0.650         P=0.237           (e)          |
|COCHRAN-ARMITAGE       |     P=0.450N                                       |     P=0.650                                        |
|FISHER EXACT           |                     P=0.370         P=0.500N       |                     P=0.247           (e)          |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05004 TEST: 04                                                 PAGE  12
                                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         8. MG/KG        15.           |      VEHICLE         8. MG/KG        15.           |
|                       |      CONTROL                         MG/KG         |      CONTROL                         MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Neurofibrosarcoma, Fibrosarcoma, or Sarcoma                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       5/50 (10%)      3/50 (6%)      |     0/50 (0%)       2/50 (4%)       0/50 (0%)      |
|ADJUSTED (b)           |      2.3%           18.7%            8.4%          |      0.0%            5.4%            0.0%          |
|TERMINAL (d)           |     0/33 (0%)       1/17 (6%)       0/16 (0%)      |     0/29 (0%)       0/25 (0%)       0/2 (0%)       |
|FIRST INCIDENCE (DAYS) |      697             600             556           |      ---             638             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.150         P=0.048 *       P=0.251        |     P=0.538         P=0.238           (e)          |
|INCIDENTAL TUMOR       |     P=0.520         P=0.214         P=0.622        |     P=0.493N        P=0.297           (e)          |
|LOGISTIC REGRESSION    |     P=0.247         P=0.085         P=0.346        |     P=0.650         P=0.237           (e)          |
|COCHRAN-ARMITAGE       |     P=0.250                                        |     P=0.650                                        |
|FISHER EXACT           |                     P=0.102         P=0.309        |                     P=0.247           (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Sarcoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       2/50 (4%)       2/50 (4%)      |     0/50 (0%)       2/50 (4%)       0/50 (0%)      |
|ADJUSTED (b)           |      2.3%            8.2%            5.1%          |      0.0%            5.4%            0.0%          |
|TERMINAL (d)           |     0/33 (0%)       1/17 (6%)       0/16 (0%)      |     0/29 (0%)       0/25 (0%)       0/2 (0%)       |
|FIRST INCIDENCE (DAYS) |      697             600             556           |      ---             638             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.314         P=0.386         P=0.458        |     P=0.538         P=0.238           (e)          |
|INCIDENTAL TUMOR       |     P=0.614         P=0.620         P=0.687N       |     P=0.493N        P=0.297           (e)          |
|LOGISTIC REGRESSION    |     P=0.404         P=0.505         P=0.565        |     P=0.650         P=0.237           (e)          |
|COCHRAN-ARMITAGE       |     P=0.393                                        |     P=0.650                                        |
|FISHER EXACT           |                     P=0.500         P=0.500        |                     P=0.247           (e)          |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05004 TEST: 04                                                 PAGE  13
                                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         8. MG/KG        15.           |      VEHICLE         8. MG/KG        15.           |
|                       |      CONTROL                         MG/KG         |      CONTROL                         MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/50 (6%)       0/50 (0%)       2/49 (4%)      |     1/50 (2%)       0/50 (0%)       2/50 (4%)      |
|ADJUSTED (b)           |      7.4%            0.0%            8.5%          |      3.4%            0.0%           15.6%          |
|TERMINAL (d)           |     0/33 (0%)       0/17 (0%)       1/16 (6%)      |     1/29 (3%)       0/25 (0%)       0/2 (0%)       |
|FIRST INCIDENCE (DAYS) |      660             ---             621           |      736 (T)         ---             716           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.508N        P=0.183N        P=0.649N       |     P=0.125         P=0.530N        P=0.100        |
|INCIDENTAL TUMOR       |     P=0.224N        P=0.045N*       P=0.280N       |     P=0.395         P=0.530N        P=0.471        |
|LOGISTIC REGRESSION    |     P=0.386N        P=0.130N        P=0.491N       |     P=0.228         P=0.530N        P=0.253        |
|COCHRAN-ARMITAGE       |     P=0.380N                                       |     P=0.388                                        |
|FISHER EXACT           |                     P=0.121N        P=0.510N       |                     P=0.500N        P=0.500        |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       1/50 (2%)       3/50 (6%)      |     2/50 (4%)       6/50 (12%)      3/50 (6%)      |
|ADJUSTED (b)           |      0.0%            3.3%           15.2%          |      6.9%           19.7%           26.9%          |
|TERMINAL (d)           |     0/33 (0%)       0/17 (0%)       2/16 (13%)     |     2/29 (7%)       3/25 (12%)      0/2 (0%)       |
|FIRST INCIDENCE (DAYS) |      ---             719             716           |      736 (T)         638             709           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.029 *       P=0.453         P=0.047 *      |     P=0.018 *       P=0.108         P=0.025 *      |
|INCIDENTAL TUMOR       |     P=0.051         P=0.602         P=0.070        |     P=0.287         P=0.138         P=0.365        |
|LOGISTIC REGRESSION    |     P=0.045 *       P=0.467         P=0.077        |     P=0.172         P=0.133         P=0.178        |
|COCHRAN-ARMITAGE       |     P=0.065                                        |     P=0.406                                        |
|FISHER EXACT           |                     P=0.500         P=0.121        |                     P=0.134         P=0.500        |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05004 TEST: 04                                                 PAGE  14
                                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         8. MG/KG        15.           |      VEHICLE         8. MG/KG        15.           |
|                       |      CONTROL                         MG/KG         |      CONTROL                         MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       0/50 (0%)       0/50 (0%)      |     2/50 (4%)       3/50 (6%)       2/50 (4%)      |
|ADJUSTED (b)           |      3.0%            0.0%            0.0%          |      6.9%           12.0%            6.5%          |
|TERMINAL (d)           |     1/33 (3%)       0/17 (0%)       0/16 (0%)      |     2/29 (7%)       3/25 (12%)      0/2 (0%)       |
|FIRST INCIDENCE (DAYS) |      736 (T)         ---             ---           |      736 (T)         736 (T)         601           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.392N        P=0.632N        P=0.644N       |     P=0.112         P=0.431         P=0.252        |
|INCIDENTAL TUMOR       |     P=0.392N        P=0.632N        P=0.644N       |     P=0.232         P=0.431         P=0.540        |
|LOGISTIC REGRESSION    |     P=0.392N        P=0.632N        P=0.644N       |     P=0.481         P=0.431         P=0.659        |
|COCHRAN-ARMITAGE       |     P=0.274N                                       |     P=0.592                                        |
|FISHER EXACT           |                     P=0.500N        P=0.500N       |                     P=0.500         P=0.691N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       0/50 (0%)       1/50 (2%)      |     2/50 (4%)       3/50 (6%)       2/50 (4%)      |
|ADJUSTED (b)           |      3.0%            0.0%            6.3%          |      6.9%           12.0%            6.5%          |
|TERMINAL (d)           |     1/33 (3%)       0/17 (0%)       1/16 (6%)      |     2/29 (7%)       3/25 (12%)      0/2 (0%)       |
|FIRST INCIDENCE (DAYS) |      736 (T)         ---             736 (T)       |      736 (T)         736 (T)         601           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.518         P=0.632N        P=0.592        |     P=0.112         P=0.431         P=0.252        |
|INCIDENTAL TUMOR       |     P=0.518         P=0.632N        P=0.592        |     P=0.232         P=0.431         P=0.540        |
|LOGISTIC REGRESSION    |     P=0.518         P=0.632N        P=0.592        |     P=0.481         P=0.431         P=0.659        |
|COCHRAN-ARMITAGE       |     P=0.665N                                       |     P=0.592                                        |
|FISHER EXACT           |                     P=0.500N        P=0.753N       |                     P=0.500         P=0.691N       |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05004 TEST: 04                                                 PAGE  15
                                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         8. MG/KG        15.           |      VEHICLE         8. MG/KG        15.           |
|                       |      CONTROL                         MG/KG         |      CONTROL                         MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |     2/50 (4%)       0/50 (0%)       4/50 (8%)      |
|ADJUSTED (b)           |                                                    |      6.4%            0.0%           14.0%          |
|TERMINAL (d)           |                                                    |     1/29 (3%)       0/25 (0%)       0/2 (0%)       |
|FIRST INCIDENCE (DAYS) |                                                    |      718             ---             549           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.085         P=0.267N        P=0.082        |
|INCIDENTAL TUMOR       |                                                    |     P=0.468         P=0.223N        P=0.580        |
|LOGISTIC REGRESSION    |                                                    |     P=0.270         P=0.240N        P=0.345        |
|COCHRAN-ARMITAGE       |                                                    |     P=0.249                                        |
|FISHER EXACT           |                                                    |                     P=0.247N        P=0.339        |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |     2/50 (4%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |                                                    |      5.5%            0.0%            0.0%          |
|TERMINAL (d)           |                                                    |     1/29 (3%)       0/25 (0%)       0/2 (0%)       |
|FIRST INCIDENCE (DAYS) |                                                    |      494             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.152N        P=0.256N        P=0.454N       |
|INCIDENTAL TUMOR       |                                                    |     P=0.126N        P=0.313N        P=0.371N       |
|LOGISTIC REGRESSION    |                                                    |     P=0.072N        P=0.234N        P=0.184N       |
|COCHRAN-ARMITAGE       |                                                    |     P=0.094N                                       |
|FISHER EXACT           |                                                    |                     P=0.247N        P=0.247N       |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05004 TEST: 04                                                 PAGE  16
                                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         8. MG/KG        15.           |      VEHICLE         8. MG/KG        15.           |
|                       |      CONTROL                         MG/KG         |      CONTROL                         MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |     4/50 (8%)       0/50 (0%)       4/50 (8%)      |
|ADJUSTED (b)           |                                                    |     11.6%            0.0%           14.0%          |
|TERMINAL (d)           |                                                    |     2/29 (7%)       0/25 (0%)       0/2 (0%)       |
|FIRST INCIDENCE (DAYS) |                                                    |      494             ---             549           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.327         P=0.079N        P=0.217        |
|INCIDENTAL TUMOR       |                                                    |     P=0.398N        P=0.081N        P=0.543N       |
|LOGISTIC REGRESSION    |                                                    |     P=0.503N        P=0.063N        P=0.597N       |
|COCHRAN-ARMITAGE       |                                                    |     P=0.563N                                       |
|FISHER EXACT           |                                                    |                     P=0.059N        P=0.643N       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     5/50 (10%)      5/50 (10%)      5/50 (10%)     |     2/50 (4%)       2/50 (4%)       3/50 (6%)      |
|ADJUSTED (b)           |     12.2%           19.0%           19.1%          |      5.4%            8.0%           21.7%          |
|TERMINAL (d)           |     1/33 (3%)       0/17 (0%)       2/16 (13%)     |     1/29 (3%)       2/25 (8%)       0/2 (0%)       |
|FIRST INCIDENCE (DAYS) |      660             704             610           |      430             736 (T)         716           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.315         P=0.405         P=0.403        |     P=0.076         P=0.654         P=0.132        |
|INCIDENTAL TUMOR       |     P=0.307N        P=0.364N        P=0.391N       |     P=0.321         P=0.607         P=0.607        |
|LOGISTIC REGRESSION    |     P=0.533         P=0.546         P=0.614N       |     P=0.386         P=0.694         P=0.506        |
|COCHRAN-ARMITAGE       |     P=0.571                                        |     P=0.417                                        |
|FISHER EXACT           |                     P=0.630N        P=0.630N       |                     P=0.691N        P=0.500        |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05004 TEST: 04                                                 PAGE  17
                                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         8. MG/KG        15.           |      VEHICLE         8. MG/KG        15.           |
|                       |      CONTROL                         MG/KG         |      CONTROL                         MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     5/50 (10%)      5/50 (10%)      5/50 (10%)     |     3/50 (6%)       2/50 (4%)       3/50 (6%)      |
|ADJUSTED (b)           |     12.2%           19.0%           19.1%          |      8.8%            8.0%           21.7%          |
|TERMINAL (d)           |     1/33 (3%)       0/17 (0%)       2/16 (13%)     |     2/29 (7%)       2/25 (8%)       0/2 (0%)       |
|FIRST INCIDENCE (DAYS) |      660             704             610           |      430             736 (T)         716           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.315         P=0.405         P=0.403        |     P=0.139         P=0.554N        P=0.154        |
|INCIDENTAL TUMOR       |     P=0.307N        P=0.364N        P=0.391N       |     P=0.433         P=0.600N        P=0.629        |
|LOGISTIC REGRESSION    |     P=0.533         P=0.546         P=0.614N       |     P=0.552         P=0.501N        P=0.639        |
|COCHRAN-ARMITAGE       |     P=0.571                                        |     P=0.586N                                       |
|FISHER EXACT           |                     P=0.630N        P=0.630N       |                     P=0.500N        P=0.661N       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma And Histiocytic Sarcoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     5/50 (10%)     12/50 (24%)      1/50 (2%)      |    20/50 (40%)     14/50 (28%)      7/50 (14%)     |
|ADJUSTED (b)           |     13.5%           44.2%            2.3%          |     55.9%           41.8%           50.1%          |
|TERMINAL (d)           |     3/33 (9%)       5/17 (29%)      0/16 (0%)      |    14/29 (48%)      7/25 (28%)      0/2 (0%)       |
|FIRST INCIDENCE (DAYS) |      676             600             612           |      414             446             652           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.493N        P=0.006 **      P=0.242N       |     P=0.438         P=0.266N        P=0.217        |
|INCIDENTAL TUMOR       |     P=0.145N        P=0.046 *       P=0.072N       |     P=0.019N*       P=0.170N        P=0.071N       |
|LOGISTIC REGRESSION    |     P=0.218N        P=0.025 *       P=0.105N       |     P=0.011N*       P=0.141N        P=0.023N*      |
|COCHRAN-ARMITAGE       |     P=0.173N                                       |     P=0.003N**                                     |
|FISHER EXACT           |                     P=0.054         P=0.102N       |                     P=0.146N        P=0.003N**     |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05004 TEST: 04                                                 PAGE  18
                                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         8. MG/KG        15.           |      VEHICLE         8. MG/KG        15.           |
|                       |      CONTROL                         MG/KG         |      CONTROL                         MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        |
|     NOS, or Undifferentiated Cell Type                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     5/50 (10%)     12/50 (24%)      1/50 (2%)      |    20/50 (40%)     14/50 (28%)      7/50 (14%)     |
|ADJUSTED (b)           |     13.5%           44.2%            2.3%          |     55.9%           41.8%           50.1%          |
|TERMINAL (d)           |     3/33 (9%)       5/17 (29%)      0/16 (0%)      |    14/29 (48%)      7/25 (28%)      0/2 (0%)       |
|FIRST INCIDENCE (DAYS) |      676             600             612           |      414             446             652           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.493N        P=0.006 **      P=0.242N       |     P=0.438         P=0.266N        P=0.217        |
|INCIDENTAL TUMOR       |     P=0.145N        P=0.046 *       P=0.072N       |     P=0.019N*       P=0.170N        P=0.071N       |
|LOGISTIC REGRESSION    |     P=0.218N        P=0.025 *       P=0.105N       |     P=0.011N*       P=0.141N        P=0.023N*      |
|COCHRAN-ARMITAGE       |     P=0.173N                                       |     P=0.003N**                                     |
|FISHER EXACT           |                     P=0.054         P=0.102N       |                     P=0.146N        P=0.003N**     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    32/50 (64%)     38/50 (76%)     46/50 (92%)     |    34/50 (68%)     38/50 (76%)     48/50 (96%)     |
|ADJUSTED (b)           |     77.6%           94.9%          100.0%          |     86.9%           88.1%          100.0%          |
|TERMINAL (d)           |    24/33 (73%)     15/17 (88%)     16/16 (100%)    |    24/29 (83%)     20/25 (80%)      2/2 (100%)     |
|FIRST INCIDENCE (DAYS) |      550             444             423           |      557             446             360           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P<0.001 **      P<0.001 **      P<0.001 **     |     P<0.001 **      P=0.136         P<0.001 **     |
|INCIDENTAL TUMOR       |     P<0.001 **      P=0.017 *       P<0.001 **     |     P<0.001 **      P=0.244         P<0.001 **     |
|LOGISTIC REGRESSION    |     P<0.001 **      P=0.017 *       P<0.001 **     |     P<0.001 **      P=0.264         P<0.001 **     |
|COCHRAN-ARMITAGE       |     P<0.001 **                                     |     P<0.001 **                                     |
|FISHER EXACT           |                     P=0.138         P<0.001 **     |                     P=0.252         P<0.001 **     |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05004 TEST: 04                                                 PAGE  19
                                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         8. MG/KG        15.           |      VEHICLE         8. MG/KG        15.           |
|                       |      CONTROL                         MG/KG         |      CONTROL                         MG/KG         |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    19/50 (38%)     41/50 (82%)     39/50 (78%)     |    30/50 (60%)     24/50 (48%)     32/50 (64%)     |
|ADJUSTED (b)           |     41.7%           89.1%           86.1%          |     73.9%           59.7%           95.9%          |
|TERMINAL (d)           |     7/33 (21%)     12/17 (71%)     10/16 (63%)     |    19/29 (66%)     10/25 (40%)      1/2 (50%)      |
|FIRST INCIDENCE (DAYS) |      514             444             423           |      414             446             475           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P<0.001 **      P<0.001 **      P<0.001 **     |     P<0.001 **      P=0.336N        P<0.001 **     |
|INCIDENTAL TUMOR       |     P<0.001 **      P<0.001 **      P=0.002 **     |     P=0.503         P=0.193N        P=0.281        |
|LOGISTIC REGRESSION    |     P<0.001 **      P<0.001 **      P<0.001 **     |     P=0.289         P=0.158N        P=0.224        |
|COCHRAN-ARMITAGE       |     P<0.001 **                                     |     P=0.408                                        |
|FISHER EXACT           |                     P<0.001 **      P<0.001 **     |                     P=0.158N        P=0.418        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    43/50 (86%)     45/50 (90%)     50/50 (100%)    |    43/50 (86%)     43/50 (86%)     50/50 (100%)    |
|ADJUSTED (b)           |     87.8%           97.8%          100.0%          |     97.7%           93.4%          100.0%          |
|TERMINAL (d)           |    27/33 (82%)     16/17 (94%)     16/16 (100%)    |    28/29 (97%)     22/25 (88%)      2/2 (100%)     |
|FIRST INCIDENCE (DAYS) |      514             444             423           |      414             446             360           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P<0.001 **      P=0.002 **      P<0.001 **     |     P<0.001 **      P=0.315         P<0.001 **     |
|INCIDENTAL TUMOR       |     P=0.028 *       P=0.255         P=0.059        |     P=0.003 **      P=0.530         P<0.001 **     |
|LOGISTIC REGRESSION    |     P=0.002 **      P=0.050 *       P=0.009 **     |     P=0.006 **      P=0.606N        P=0.005 **     |
|COCHRAN-ARMITAGE       |     P=0.009 **                                     |     P=0.015 *                                      |
|FISHER EXACT           |                     P=0.380         P=0.006 **     |                     P=0.613N        P=0.006 **     |
|=================================================================================================================================|
 
         DATE: 09/03/94                     EXPERIMENT: 05004 TEST: 04                                                 PAGE  20
                                    STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN
 
                                                 TERMINAL SACRIFICE AT 106 WEEKS
 
 
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
 
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).

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