National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2690

TDMS Study 05004-03 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                               FURAN


NTP Experiment-Test: 05004-03                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/02/94
Route: GAVAGE                                                                                                     Time: 23:55:48




       Facility:  Southern Research Institute

       Chemical CAS #:  110-00-9

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05004-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 23:55:48  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      2. MG/KG     4. MG/KG     8. MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund                                          12           17           17           19                                     
    Dead                                               4            1            5           10                                     
    Dosing Accident                                                                           2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           32           28           19                                     
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (49)         (50)         (50)         (49)                                   
      Parasite Metazoan                                3 (6%)       2 (4%)                    1 (2%)                                
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
      Parasite Metazoan                                2 (4%)       6 (12%)                   6 (12%)                               
   Intestine Large, Rectum                            (49)         (50)         (50)         (50)                                   
      Parasite Metazoan                                5 (10%)     12 (24%)      7 (14%)      4 (8%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Basophilic Focus                                43 (86%)     38 (76%)      1 (2%)                                             
      Clear Cell Focus                                 1 (2%)                                                                       
      Cyst Multilocular                                             6 (12%)      2 (4%)      12 (24%)                               
      Developmental Malformation                       9 (18%)      1 (2%)       3 (6%)       3 (6%)                                
      Eosinophilic Focus                              17 (34%)                                                                      
      Granuloma, Multiple                             10 (20%)     19 (38%)      8 (16%)                                            
      Hematopoietic Cell Proliferation, Multifocal                  7 (14%)      7 (14%)                                            
      Hemorrhage, Focal                                                          1 (2%)       2 (4%)                                
      Hemorrhage, Multifocal                                                     1 (2%)       3 (6%)                                
      Hyperplasia, Multifocal, Nodular                                                        1 (2%)                                
      Necrosis, Focal                                  1 (2%)                                                                       
      Neovascularization                                                         4 (8%)       8 (16%)                               
      Pigmentation, Hematoidin                                                   1 (2%)       1 (2%)                                
      Pigmentation, Hemosiderin, Multifocal                                      1 (2%)                                             
      Thrombosis                                                                 1 (2%)       1 (2%)                                
      Biliary Tract, Cyst, Multiple                                49 (98%)     50 (100%)    46 (92%)                               
      Biliary Tract, Fibrosis, Multifocal                          49 (98%)     50 (100%)    49 (98%)                               
      Biliary Tract, Hyperplasia, Multifocal                       49 (98%)     50 (100%)    49 (98%)                               
      Biliary Tract, Inflammation, Chronic,                                                                                         
          Multifocal                                               49 (98%)     50 (100%)    49 (98%)                               
      Biliary Tract, Metaplasia                                    49 (98%)     50 (100%)    49 (98%)                               
      Biliary Tract, Proliferation                    11 (22%)                                                                      
      Centrilobular, Necrosis                          8 (16%)      2 (4%)      10 (20%)      2 (4%)                                
      Hepatocyte, Cytomegaly                                       44 (88%)     50 (100%)    49 (98%)                               
      Hepatocyte, Degeneration, Multifocal                         35 (70%)     49 (98%)     47 (94%)                               
      Hepatocyte, Hyperplasia, Multifocal, Nodular                 32 (64%)     47 (94%)     46 (92%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05004-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 23:55:48  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      2. MG/KG     4. MG/KG     8. MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hepatocyte, Necrosis, Multifocal                             18 (36%)     46 (92%)     47 (94%)                               
      Hepatocyte, Vacuolization Cytoplasmic                        43 (86%)     49 (98%)     47 (94%)                               
      Kupffer Cell, Pigmentation, Multifocal                       49 (98%)     50 (100%)    48 (96%)                               
      Serosa, Inflammation, Chronic                    1 (2%)                                                                       
   Mesentery                                          (8)          (12)         (9)          (13)                                   
      Inflammation, Chronic, Diffuse                   1 (13%)                                                                      
      Mineralization, Focal                                                      1 (11%)      2 (15%)                               
      Fat, Necrosis, Focal                             6 (75%)     11 (92%)      5 (56%)      7 (54%)                               
      Fat, Necrosis, Multifocal                        2 (25%)      1 (8%)       1 (11%)      2 (15%)                               
   Pancreas                                           (50)         (49)         (50)         (50)                                   
      Atrophy, Focal                                   4 (8%)       6 (12%)      6 (12%)      2 (4%)                                
      Atrophy, Multifocal                              3 (6%)       5 (10%)      1 (2%)       1 (2%)                                
      Hyperplasia, Focal                               4 (8%)       1 (2%)       2 (4%)       2 (4%)                                
      Hyperplasia, Multifocal                          1 (2%)       1 (2%)       1 (2%)                                             
      Acinus, Atrophy                                  1 (2%)                                                                       
      Acinus, Hyperplasia                              1 (2%)                                                                       
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Atrophy, Multifocal                                                        1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Edema, Diffuse                                   1 (2%)                                                                       
      Erosion                                                       1 (2%)       1 (2%)       2 (4%)                                
      Hyperkeratosis                                                                          1 (2%)                                
      Hyperplasia                                                   2 (4%)       5 (10%)      5 (10%)                               
      Hyperplasia, Squamous                                                                   1 (2%)                                
      Inflammation, Subacute                                        1 (2%)       5 (10%)      6 (12%)                               
      Perforation                                                                2 (4%)                                             
      Ulcer                                            2 (4%)                    2 (4%)       3 (6%)                                
      Ulcer, Multiple                                                            1 (2%)                                             
      Artery, Inflammation, Subacute                                1 (2%)                                                          
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Edema, Diffuse                                                             2 (4%)                                             
      Erosion                                                       1 (2%)       2 (4%)       1 (2%)                                
      Erosion, Multiple                                                          1 (2%)       1 (2%)                                
      Inflammation, Subacute                                        1 (2%)                                                          
      Mineralization                                   1 (2%)                                                                       
      Mineralization, Multifocal                                                              1 (2%)                                
      Ulcer                                                         1 (2%)       1 (2%)       1 (2%)                                
      Ulcer, Multiple                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                    (1)                                    
      Abdominal, Hypertrophy                                                                  1 (100%)                              
      Abdominal, Inflammation, Subacute                                                       1 (100%)                              
      Abdominal, Thrombosis                                                                   1 (100%)                              
      Aorta, Inflammation, Chronic                     1 (100%)                                                                     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05004-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 23:55:48  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      2. MG/KG     4. MG/KG     8. MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  17 (34%)     25 (50%)     11 (22%)     32 (64%)                               
      Granuloma                                                     1 (2%)                                                          
      Mineralization, Multifocal                                                              1 (2%)                                
      Thrombosis                                                                              1 (2%)                                
      Pericardium, Fibrosis                                         1 (2%)                                                          
      Pericardium, Necrosis, Focal                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)         (50)                                   
      Accessory Adrenal Cortical Nodule                1 (2%)       1 (2%)       1 (2%)       3 (6%)                                
      Angiectasis                                      3 (6%)                                                                       
      Focal Cellular Change                            9 (18%)      9 (18%)      7 (14%)      3 (6%)                                
      Hematopoietic Cell Proliferation                                           1 (2%)       1 (2%)                                
      Hemorrhage                                                                 1 (2%)                                             
      Hypertrophy, Focal                               1 (2%)                                                                       
      Necrosis, Diffuse                                1 (2%)                    1 (2%)                                             
      Necrosis, Multifocal                                                       2 (4%)                                             
      Thrombosis                                                    1 (2%)                                                          
      Vacuolization Cytoplasmic, Diffuse               1 (2%)                                 1 (2%)                                
      Vacuolization Cytoplasmic, Focal                 1 (2%)                                                                       
      Vacuolization Cytoplasmic, Multifocal            1 (2%)                                                                       
   Adrenal Gland, Medulla                             (50)         (49)         (50)         (49)                                   
      Cyst                                                          1 (2%)                                                          
      Hyperplasia, Focal                               1 (2%)                    1 (2%)       2 (4%)                                
      Hyperplasia, Multifocal                                       1 (2%)                    1 (2%)                                
      Necrosis, Diffuse                                1 (2%)                                                                       
   Parathyroid Gland                                  (48)         (50)         (49)         (46)                                   
      Hyperplasia                                                                2 (4%)       9 (20%)                               
   Pituitary Gland                                    (50)         (50)         (49)         (49)                                   
      Pars Distalis, Angiectasis                      31 (62%)     30 (60%)     29 (59%)     22 (45%)                               
      Pars Distalis, Cyst                             18 (36%)      9 (18%)     16 (33%)     20 (41%)                               
      Pars Distalis, Hyperplasia                       2 (4%)       2 (4%)       4 (8%)       2 (4%)                                
      Pars Distalis, Hyperplasia, Focal                9 (18%)     11 (22%)     12 (24%)     18 (37%)                               
      Pars Distalis, Pigmentation, Hemosiderin        11 (22%)     19 (38%)     17 (35%)     10 (20%)                               
   Thyroid Gland                                      (50)         (50)         (50)         (49)                                   
      Ultimobranchial Cyst                             1 (2%)                                                                       
      C-Cell, Hyperplasia                                           1 (2%)       2 (4%)                                             
      C-Cell, Hyperplasia, Focal                       7 (14%)      6 (12%)      4 (8%)       8 (16%)                               
      C-Cell, Hyperplasia, Multifocal                  5 (10%)      2 (4%)       4 (8%)                                             
      Follicle, Cyst                                                             1 (2%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05004-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 23:55:48  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      2. MG/KG     4. MG/KG     8. MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (43)         (48)         (50)         (47)                                   
      Hyperplasia                                      4 (9%)                                 2 (4%)                                
      Hyperplasia, Focal                                                         1 (2%)                                             
      Inflammation, Acute, Focal, Suppurative          2 (5%)       1 (2%)       1 (2%)       2 (4%)                                
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Focal, Subacute                                              1 (2%)                                             
      Duct, Cyst                                                    5 (10%)      5 (10%)      5 (11%)                               
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Cyst                                            12 (24%)      3 (6%)       3 (6%)       6 (12%)                               
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Abscess                                          1 (2%)                                                                       
      Cyst                                             2 (4%)                                 2 (4%)                                
      Hemorrhage                                                                 2 (4%)       1 (2%)                                
      Hydrometra                                       2 (4%)       3 (6%)                                                          
      Hyperplasia, Cystic                              1 (2%)       4 (8%)       2 (4%)                                             
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Acute, Suppurative                 1 (2%)                                                                       
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Prolapse                                                      1 (2%)       1 (2%)                                             
      Cervix, Cyst                                     1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
      Cervix, Cyst, Multiple                           1 (2%)                                                                       
      Cervix, Hypertrophy                              1 (2%)                                                                       
   Vagina                                             (2)          (1)          (2)                                                 
      Inflammation, Acute, Suppurative                                           1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                   8 (16%)     11 (22%)     24 (48%)                               
      Infiltration Cellular, Histiocyte                             1 (2%)                                                          
      Myelofibrosis                                                 1 (2%)       2 (4%)                                             
   Lymph Node                                         (50)         (50)         (50)         (50)                                   
      Pancreatic, Ectasia                                           6 (12%)     16 (32%)     23 (46%)                               
      Pancreatic, Hyperplasia                                       2 (4%)       2 (4%)       1 (2%)                                
      Pancreatic, Inflammation, Granulomatous                                    1 (2%)                                             
      Pancreatic, Necrosis                                                                    1 (2%)                                
      Renal, Ectasia                                                             1 (2%)       1 (2%)                                
   Lymph Node, Bronchial                              (27)         (43)         (42)         (30)                                   
      Ectasia                                                       1 (2%)                    1 (3%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05004-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 23:55:48  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      2. MG/KG     4. MG/KG     8. MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Lymph Node, Mandibular                             (47)         (48)         (47)         (46)                                   
      Ectasia                                          3 (6%)       4 (8%)       3 (6%)       2 (4%)                                
      Hyperplasia                                      1 (2%)       1 (2%)       1 (2%)       3 (7%)                                
      Inflammation, Acute, Suppurative                 1 (2%)                                                                       
   Lymph Node, Mediastinal                            (48)         (48)         (49)         (49)                                   
      Congestion                                       1 (2%)                                 2 (4%)                                
      Ectasia                                                       3 (6%)       4 (8%)      10 (20%)                               
      Hyperplasia                                                                             1 (2%)                                
   Lymph Node, Mesenteric                             (48)         (50)         (50)         (48)                                   
      Ectasia                                                       1 (2%)       1 (2%)                                             
      Hyperplasia                                                                             2 (4%)                                
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Congestion                                       2 (4%)       6 (12%)     17 (34%)     23 (46%)                               
      Fibrosis, Focal                                  3 (6%)                    2 (4%)       1 (2%)                                
      Hematopoietic Cell Proliferation                 8 (16%)     14 (28%)     27 (54%)     25 (50%)                               
      Inflammation, Chronic, Focal                                                            1 (2%)                                
      Necrosis, Diffuse                                                                       1 (2%)                                
      Necrosis, Focal                                                            2 (4%)       2 (4%)                                
      Pigmentation, Hemosiderin                                                  1 (2%)                                             
      Thrombosis                                                                              1 (2%)                                
   Thymus                                             (47)         (46)         (47)         (43)                                   
      Cyst                                             1 (2%)       3 (7%)       1 (2%)                                             
      Hemorrhage                                                                              1 (2%)                                
      Fat, Mediastinum, Inflammation, Chronic          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (49)         (50)                                   
      Duct, Cyst                                      43 (86%)     44 (88%)     45 (92%)     43 (86%)                               
   Skin                                               (50)         (50)         (50)         (50)                                   
      Foreign Body                                     1 (2%)                                                                       
      Inflammation, Focal, Granulomatous               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Cranium, Hypertrophy, Focal                      2 (4%)       4 (8%)       6 (12%)      2 (4%)                                
      Femur, Hypertrophy, Focal                        1 (2%)       5 (10%)      2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05004-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 23:55:48  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      2. MG/KG     4. MG/KG     8. MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Compression                                      2 (4%)       3 (6%)       2 (4%)       2 (4%)                                
      Degeneration, Multifocal                         1 (2%)                                                                       
      Hemorrhage, Focal                                             1 (2%)                    1 (2%)                                
      Hemorrhage, Multifocal                           1 (2%)       1 (2%)                    3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Abscess                                                       1 (2%)                                                          
      Congestion                                       1 (2%)                                 4 (8%)                                
      Foreign Body                                     1 (2%)                                 2 (4%)                                
      Granuloma, Multiple                             12 (24%)     14 (28%)     14 (28%)     11 (22%)                               
      Hemorrhage, Multifocal                                                     1 (2%)       3 (6%)                                
      Infiltration Cellular, Focal, Histiocyte         1 (2%)       5 (10%)      4 (8%)       2 (4%)                                
      Infiltration Cellular, Multifocal, Histiocyte    1 (2%)       4 (8%)       8 (16%)      3 (6%)                                
      Pigmentation, Focal, Cholesterol                 1 (2%)       3 (6%)       3 (6%)       3 (6%)                                
      Pigmentation, Multifocal, Cholesterol                         2 (4%)       2 (4%)       2 (4%)                                
      Alveolar Epithelium, Hyperplasia, Focal          4 (8%)       2 (4%)       1 (2%)       4 (8%)                                
      Alveolar Epithelium, Hyperplasia, Multifocal     1 (2%)       1 (2%)       1 (2%)                                             
      Fat, Mediastinum, Necrosis, Multifocal           2 (4%)      10 (20%)     11 (22%)      4 (8%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Foreign Body                                                  2 (4%)       2 (4%)       2 (4%)                                
      Fungus                                                        1 (2%)       3 (6%)       2 (4%)                                
      Inflammation, Acute, Suppurative                              4 (8%)       5 (10%)      2 (4%)                                
      Mucosa, Cyst                                                               1 (2%)                                             
      Nasolacrimal Duct, Foreign Body                               1 (2%)                                                          
      Nasolacrimal Duct, Hyperkeratosis                                          1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Acute,                                                                                       
          Suppurative                                  1 (2%)                    3 (6%)       1 (2%)                                
      Nasolacrimal Duct, Inflammation, Subacute        4 (8%)       3 (6%)      10 (20%)      3 (6%)                                
      Nasopharyngeal Duct, Foreign Body                             1 (2%)                                                          
      Nasopharyngeal Duct, Inflammation, Subacute                   2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (3)          (2)                                                 
      Cataract                                         1 (50%)      3 (100%)     1 (50%)                                            
      Hemorrhage                                                    1 (33%)      2 (100%)                                           
      Inflammation, Subacute                           1 (50%)                                                                      
      Retina, Degeneration                             1 (50%)      2 (67%)      1 (50%)                                            
   Harderian Gland                                    (2)                       (1)          (1)                                    
      Inflammation, Chronic, Focal                     2 (100%)                  1 (100%)                                           
   Lacrimal Gland                                     (1)                       (1)                                                 
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05004-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 23:55:48  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      2. MG/KG     4. MG/KG     8. MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - CONT                                                                                                        
      Inflammation, Chronic, Suppurative                                         1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Cyst Multilocular                                1 (2%)                                                                       
      Developmental Malformation                                                              1 (2%)                                
      Nephropathy, Chronic                            16 (32%)     47 (94%)     47 (94%)     46 (92%)                               
      Cortex, Fibrosis, Focal                                       1 (2%)       1 (2%)                                             
      Papilla, Necrosis                                                          1 (2%)                                             
      Pelvis, Inflammation, Acute, Suppurative                                   1 (2%)                                             
      Renal Tubule, Mineralization, Multifocal                                                1 (2%)                                
      Renal Tubule, Necrosis, Multifocal                                                      1 (2%)                                
      Transitional Epithelium, Hyperplasia                                       1 (2%)                                             
   Urinary Bladder                                    (49)         (50)         (49)         (50)                                   
      Calculus Gross Observation                                                 1 (2%)                                             
      Transitional Epithelium, Hyperplasia                                       1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05004-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 23:55:48  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      2. MG/KG     4. MG/KG     8. MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Dosing Accident                                    6            5            4            1                                     
    Dead                                               1            4            3            5                                     
    Moribund                                          10           13           17           28                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           28           26           16                                     
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (48)         (50)         (50)         (49)                                   
      Hemorrhage, Focal                                             1 (2%)                                                          
   Intestine Large, Cecum                             (49)         (50)         (50)         (50)                                   
      Parasite Metazoan                                2 (4%)       1 (2%)       4 (8%)                                             
      Ulcer, Multiple                                  1 (2%)                                                                       
   Intestine Large, Colon                             (49)         (49)         (50)         (50)                                   
      Diverticulum                                                  1 (2%)                                                          
      Parasite Metazoan                                4 (8%)       2 (4%)       3 (6%)       6 (12%)                               
   Intestine Large, Rectum                            (50)         (49)         (48)         (50)                                   
      Fibrosis, Focal                                                            1 (2%)                                             
      Parasite Metazoan                                5 (10%)      6 (12%)      6 (13%)      2 (4%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis, Focal                                                         1 (2%)                                             
      Basophilic Focus                                32 (64%)     20 (40%)      2 (4%)       1 (2%)                                
      Clear Cell Focus                                 8 (16%)                                                                      
      Cyst Multilocular                                             1 (2%)      17 (34%)     24 (48%)                               
      Degeneration, Cystic                             2 (4%)                                                                       
      Degeneration, Cystic, Focal                      3 (6%)                                                                       
      Degeneration, Cystic, Multifocal                 1 (2%)                                                                       
      Developmental Malformation                       3 (6%)       3 (6%)       3 (6%)       1 (2%)                                
      Eosinophilic Focus                              14 (28%)                                                                      
      Granuloma, Multiple                              1 (2%)      21 (42%)     10 (20%)      1 (2%)                                
      Hematopoietic Cell Proliferation, Multifocal     1 (2%)       3 (6%)       3 (6%)                                             
      Hemorrhage, Multifocal                                        1 (2%)       1 (2%)       5 (10%)                               
      Leukocytosis                                                  1 (2%)                                                          
      Necrosis, Focal                                  1 (2%)                    1 (2%)                                             
      Neovascularization                                            6 (12%)     14 (28%)     15 (30%)                               
      Thrombosis                                                                 3 (6%)       4 (8%)                                
      Biliary Tract, Cyst, Multiple                                44 (88%)     47 (94%)     49 (98%)                               
      Biliary Tract, Ectasia, Focal                    1 (2%)                                                                       
      Biliary Tract, Fibrosis, Multifocal                          44 (88%)     48 (96%)     49 (98%)                               
      Biliary Tract, Hyperplasia, Multifocal                       44 (88%)     48 (96%)     49 (98%)                               
      Biliary Tract, Inflammation, Chronic,                                                                                         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05004-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 23:55:48  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      2. MG/KG     4. MG/KG     8. MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
          Multifocal                                               44 (88%)     48 (96%)     49 (98%)                               
      Biliary Tract, Metaplasia                                    44 (88%)     48 (96%)     49 (98%)                               
      Biliary Tract, Proliferation                    39 (78%)                                                                      
      Centrilobular, Necrosis                          5 (10%)      7 (14%)      5 (10%)      9 (18%)                               
      Hepatocyte, Cytomegaly                                       35 (70%)     46 (92%)     49 (98%)                               
      Hepatocyte, Degeneration, Multifocal                         33 (66%)     46 (92%)     49 (98%)                               
      Hepatocyte, Hyperplasia, Multifocal, Nodular                 30 (60%)     46 (92%)     49 (98%)                               
      Hepatocyte, Necrosis, Multifocal                             32 (64%)     46 (92%)     49 (98%)                               
      Hepatocyte, Vacuolization Cytoplasmic            1 (2%)      39 (78%)     45 (90%)     49 (98%)                               
      Kupffer Cell, Pigmentation, Multifocal                       44 (88%)     48 (96%)     49 (98%)                               
   Mesentery                                          (5)          (12)         (12)         (14)                                   
      Foreign Body                                                  1 (8%)                                                          
      Inflammation, Acute, Suppurative                              1 (8%)                                                          
      Pigmentation, Hemosiderin, Multifocal                                      1 (8%)       3 (21%)                               
      Fat, Hemorrhage                                                                         1 (7%)                                
      Fat, Necrosis, Focal                             3 (60%)      7 (58%)      9 (75%)      6 (43%)                               
      Fat, Necrosis, Multifocal                                                               1 (7%)                                
   Pancreas                                           (50)         (50)         (50)         (49)                                   
      Atrophy, Focal                                   9 (18%)      2 (4%)       1 (2%)       6 (12%)                               
      Atrophy, Multifocal                              6 (12%)      7 (14%)      3 (6%)       5 (10%)                               
      Cyst Multilocular                                                          1 (2%)                                             
      Hyperplasia                                      2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Hyperplasia, Focal                               8 (16%)     12 (24%)      9 (18%)     12 (24%)                               
      Hyperplasia, Multifocal                         13 (26%)      9 (18%)      6 (12%)     10 (20%)                               
      Inflammation, Chronic, Focal                     1 (2%)                    2 (4%)                                             
      Inflammation, Focal, Subacute                    1 (2%)                                                                       
      Pigmentation, Hemosiderin                                                  1 (2%)                                             
      Artery, Inflammation, Subacute                                1 (2%)                                                          
   Stomach, Forestomach                               (50)         (49)         (50)         (50)                                   
      Edema                                                                                   3 (6%)                                
      Hyperkeratosis                                                             1 (2%)                                             
      Hyperplasia                                      1 (2%)       4 (8%)       7 (14%)      6 (12%)                               
      Hyperplasia, Squamous                                                                   1 (2%)                                
      Inflammation, Subacute                           1 (2%)       2 (4%)       6 (12%)      2 (4%)                                
      Perforation                                                   1 (2%)       3 (6%)                                             
      Ulcer                                                         1 (2%)       3 (6%)       3 (6%)                                
      Ulcer, Multiple                                                            1 (2%)       3 (6%)                                
      Artery, Inflammation, Subacute                                2 (4%)                                                          
      Serosa, Fibrosis, Focal                                                                 1 (2%)                                
   Stomach, Glandular                                 (50)         (49)         (50)         (50)                                   
      Edema                                                                                   2 (4%)                                
      Erosion                                                                    2 (4%)       1 (2%)                                
      Erosion, Multiple                                1 (2%)                    1 (2%)       1 (2%)                                
      Inflammation, Subacute                                                     1 (2%)                                             
      Mineralization, Multifocal                                                 1 (2%)       2 (4%)                                
      Ulcer                                                                      1 (2%)       2 (4%)                                
   Tongue                                             (1)                       (2)                                                 
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05004-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 23:55:48  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      2. MG/KG     4. MG/KG     8. MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Foreign Body                                     1 (100%)                                                                     
      Hemorrhage                                                                 1 (50%)                                            
      Inflammation, Granulomatous                      1 (100%)                                                                     
   Tooth                                              (1)          (1)          (1)                                                 
      Dysplasia                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (1)                                                              
      Aorta, Mineralization                                         1 (100%)                                                        
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  29 (58%)     30 (60%)     38 (76%)     39 (78%)                               
      Fibrosis, Focal                                                            1 (2%)                                             
      Inflammation, Acute, Multifocal, Suppurative     1 (2%)                                                                       
      Mineralization, Multifocal                                    1 (2%)                    1 (2%)                                
      Thrombosis                                       1 (2%)       1 (2%)                    1 (2%)                                
      Valve, Embolus Bacterial                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)         (50)                                   
      Accessory Adrenal Cortical Nodule                                                       2 (4%)                                
      Focal Cellular Change                            2 (4%)       7 (14%)      7 (14%)      2 (4%)                                
      Hematopoietic Cell Proliferation, Multifocal                  2 (4%)                                                          
      Hemorrhage                                                    1 (2%)       1 (2%)                                             
      Necrosis, Diffuse                                                          1 (2%)                                             
      Vacuolization Cytoplasmic, Diffuse               1 (2%)                                                                       
      Capsule, Fibrosis, Focal                                                                1 (2%)                                
      Left, Atrophy                                                              1 (2%)                                             
   Adrenal Gland, Medulla                             (50)         (47)         (48)         (49)                                   
      Hyperplasia                                                                1 (2%)                                             
      Hyperplasia, Focal                               2 (4%)       7 (15%)      1 (2%)       3 (6%)                                
      Hyperplasia, Multifocal                                                    1 (2%)       1 (2%)                                
      Necrosis, Diffuse                                             1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (50)         (50)         (49)                                   
      Hyperplasia                                      1 (2%)       1 (2%)       1 (2%)                                             
   Parathyroid Gland                                  (46)         (47)         (49)         (43)                                   
      Hyperplasia                                                   2 (4%)      10 (20%)      6 (14%)                               
   Pituitary Gland                                    (49)         (50)         (49)         (49)                                   
      Pars Distalis, Angiectasis                      10 (20%)     18 (36%)     18 (37%)      8 (16%)                               
      Pars Distalis, Cyst                              2 (4%)       2 (4%)       4 (8%)       4 (8%)                                
      Pars Distalis, Hyperplasia                       1 (2%)                    2 (4%)       2 (4%)                                
      Pars Distalis, Hyperplasia, Focal               10 (20%)     12 (24%)      5 (10%)      6 (12%)                               
      Pars Distalis, Necrosis                                       1 (2%)                                                          
      Pars Distalis, Pigmentation, Hemosiderin         7 (14%)     10 (20%)      3 (6%)       6 (12%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05004-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 23:55:48  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      2. MG/KG     4. MG/KG     8. MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Intermedia, Cyst                                                                   1 (2%)                                
   Thyroid Gland                                      (48)         (50)         (50)         (48)                                   
      Ultimobranchial Cyst                             1 (2%)                                                                       
      C-Cell, Hyperplasia                              2 (4%)       1 (2%)                    1 (2%)                                
      C-Cell, Hyperplasia, Focal                       3 (6%)       2 (4%)       1 (2%)       1 (2%)                                
      C-Cell, Hyperplasia, Multifocal                  1 (2%)       1 (2%)       1 (2%)                                             
      Follicle, Cyst                                   2 (4%)                    4 (8%)       6 (13%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (49)         (50)         (46)         (48)                                   
      Foreign Body                                     1 (2%)                                                                       
      Granuloma                                        1 (2%)                                                                       
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Acute, Focal, Suppurative          3 (6%)       2 (4%)       1 (2%)       3 (6%)                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Focal, Subacute                    1 (2%)       1 (2%)       1 (2%)                                             
      Duct, Cyst                                       1 (2%)       5 (10%)                   4 (8%)                                
   Prostate                                           (50)         (50)         (50)         (49)                                   
      Inflammation, Acute, Suppurative                                                        1 (2%)                                
      Inflammation, Subacute                           8 (16%)     22 (44%)     26 (52%)     11 (22%)                               
   Seminal Vesicle                                    (1)                       (4)          (1)                                    
      Inflammation, Acute, Suppurative                                                        1 (100%)                              
      Inflammation, Subacute                                                     3 (75%)                                            
   Testes                                             (50)         (50)         (50)         (50)                                   
      Atrophy                                          2 (4%)       5 (10%)      4 (8%)       3 (6%)                                
      Interstitial Cell, Hyperplasia                                4 (8%)       3 (6%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                                                        (1)          (1)                                    
      Polychromasia                                                                           1 (100%)                              
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                   8 (16%)      9 (18%)     28 (56%)                               
      Necrosis                                         1 (2%)                                                                       
   Lymph Node                                         (50)         (50)         (50)         (50)                                   
      Inguinal, Ectasia                                             1 (2%)                                                          
      Inguinal, Hyperplasia                                         1 (2%)                                                          
      Inguinal, Inflammation, Granulomatous                                      1 (2%)                                             
      Pancreatic, Ectasia                                           4 (8%)      12 (24%)     24 (48%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05004-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 23:55:48  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      2. MG/KG     4. MG/KG     8. MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Pancreatic, Hyperplasia                                       3 (6%)       2 (4%)      10 (20%)                               
      Pancreatic, Inflammation, Granulomatous                                    1 (2%)                                             
      Renal, Ectasia                                                                          3 (6%)                                
      Renal, Hyperplasia                                                                      1 (2%)                                
   Lymph Node, Bronchial                              (34)         (40)         (35)         (27)                                   
      Congestion                                                                              1 (4%)                                
      Ectasia                                          1 (3%)                    2 (6%)                                             
      Hyperplasia                                                                             2 (7%)                                
      Inflammation, Granulomatous                                                1 (3%)                                             
   Lymph Node, Mandibular                             (48)         (45)         (48)         (48)                                   
      Congestion                                                                              1 (2%)                                
      Ectasia                                         10 (21%)      6 (13%)      7 (15%)     13 (27%)                               
      Hyperplasia                                      1 (2%)       2 (4%)       1 (2%)       6 (13%)                               
      Hyperplasia, Lymphoid                                         1 (2%)       1 (2%)                                             
      Inflammation, Granulomatous                                                1 (2%)                                             
   Lymph Node, Mediastinal                            (48)         (45)         (48)         (45)                                   
      Congestion                                       1 (2%)                                 2 (4%)                                
      Ectasia                                                       5 (11%)      7 (15%)     16 (36%)                               
      Hyperplasia                                                   1 (2%)                    9 (20%)                               
      Inflammation, Granulomatous                                                1 (2%)                                             
      Pigmentation, Hemosiderin                                                  2 (4%)       1 (2%)                                
   Lymph Node, Mesenteric                             (46)         (50)         (49)         (49)                                   
      Congestion                                                    1 (2%)                                                          
      Ectasia                                          2 (4%)                    2 (4%)       7 (14%)                               
      Hyperplasia                                                   1 (2%)                    2 (4%)                                
      Inflammation, Granulomatous                                                1 (2%)                                             
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Atrophy                                                       1 (2%)                                                          
      Congestion                                       5 (10%)     16 (32%)     25 (50%)     25 (50%)                               
      Degeneration, Fatty, Multifocal                                                         1 (2%)                                
      Fibrosis, Focal                                  4 (8%)       4 (8%)       7 (14%)      7 (14%)                               
      Hematopoietic Cell Proliferation                 9 (18%)     23 (46%)     27 (54%)     30 (60%)                               
      Inflammation, Granulomatous                                                1 (2%)                                             
      Necrosis, Focal                                  1 (2%)                                 1 (2%)                                
      Capsule, Fibrosis, Multifocal                                              1 (2%)                                             
      Capsule, Pigmentation, Hemosiderin                                         1 (2%)                                             
   Thymus                                             (48)         (49)         (46)         (42)                                   
      Cyst                                                          2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (50)         (50)         (50)                                   
      Duct, Cyst                                      20 (42%)     24 (48%)     29 (58%)     20 (40%)                               
      Duct, Hemorrhage, Focal                                                                 1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Bacterium                                                                  1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05004-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 23:55:48  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      2. MG/KG     4. MG/KG     8. MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Foreign Body                                                               1 (2%)                                             
      Inflammation, Focal, Subacute                                              1 (2%)                                             
      Inflammation, Multifocal, Subacute               1 (2%)                                                                       
      Subcutaneous Tissue, Edema, Focal                             1 (2%)                    3 (6%)                                
      Subcutaneous Tissue, Inflammation, Focal,                                                                                     
           Subacute                                                 1 (2%)                    2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrous Osteodystrophy                                        1 (2%)       1 (2%)       4 (8%)                                
   Skeletal Muscle                                                 (1)                       (1)                                    
      Inflammation, Acute, Suppurative                              1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Compression                                                   1 (2%)       2 (4%)       1 (2%)                                
      Cyst                                             1 (2%)                                                                       
      Hemorrhage, Multifocal                           1 (2%)       1 (2%)       3 (6%)                                             
      Hydrocephalus                                                 1 (2%)                                                          
      Inflammation, Acute, Multifocal, Suppurative     1 (2%)                                                                       
   Spinal Cord                                        (1)                                                                           
      Degeneration                                     1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                       6 (12%)      6 (12%)      3 (6%)       4 (8%)                                
      Foreign Body                                     5 (10%)      6 (12%)      4 (8%)       2 (4%)                                
      Fungus                                                                                  1 (2%)                                
      Granuloma, Multiple                              9 (18%)      8 (16%)      4 (8%)       9 (18%)                               
      Hemorrhage, Focal                                                                       2 (4%)                                
      Hemorrhage, Multifocal                                        1 (2%)                    1 (2%)                                
      Hyperplasia                                      1 (2%)                                                                       
      Infiltration Cellular, Focal, Histiocyte                                   1 (2%)       3 (6%)                                
      Infiltration Cellular, Multifocal, Histiocyte                 2 (4%)                    4 (8%)                                
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
      Inflammation, Focal, Granulomatous                                                      1 (2%)                                
      Inflammation, Subacute                           1 (2%)                                                                       
      Pigmentation, Focal, Cholesterol                                           1 (2%)       1 (2%)                                
      Pigmentation, Multifocal, Cholesterol                                                   1 (2%)                                
      Thrombosis                                                                              1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 2 (4%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05004-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 23:55:48  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      2. MG/KG     4. MG/KG     8. MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Alveolar Epithelium, Hyperplasia, Focal          2 (4%)       1 (2%)       3 (6%)       3 (6%)                                
      Alveolar Epithelium, Hyperplasia, Multifocal                  1 (2%)                    1 (2%)                                
      Fat, Mediastinum, Necrosis, Multifocal           1 (2%)       1 (2%)       1 (2%)       5 (10%)                               
      Mediastinum, Foreign Body                                                               1 (2%)                                
      Mediastinum, Inflammation, Chronic                                                      1 (2%)                                
      Mediastinum, Inflammation, Chronic,                                                                                           
          Multifocal                                   1 (2%)                                                                       
      Pleura, Fibrosis, Focal                          1 (2%)                                                                       
      Smooth Muscle, Hyperplasia, Focal                             1 (2%)                                                          
   Nose                                               (50)         (50)         (50)         (50)                                   
      Foreign Body                                    16 (32%)      2 (4%)       6 (12%)      5 (10%)                               
      Fungus                                           5 (10%)      5 (10%)      6 (12%)      4 (8%)                                
      Hyperkeratosis, Focal                                         1 (2%)                                                          
      Hyperplasia, Squamous                                         1 (2%)                                                          
      Inflammation, Acute, Suppurative                11 (22%)      7 (14%)      8 (16%)      7 (14%)                               
      Nasolacrimal Duct, Inflammation, Acute,                                                                                       
          Suppurative                                  4 (8%)       1 (2%)       1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Subacute        1 (2%)       9 (18%)      2 (4%)       3 (6%)                                
      Nasopharyngeal Duct, Cyst                        1 (2%)                    1 (2%)                                             
      Nasopharyngeal Duct, Foreign Body                1 (2%)                                                                       
      Nasopharyngeal Duct, Fungus                                   1 (2%)                                                          
      Nasopharyngeal Duct, Hyperplasia                              1 (2%)                                                          
      Nasopharyngeal Duct, Inflammation, Acute,                                                                                     
           Suppurative                                              1 (2%)                                                          
      Nasopharyngeal Duct, Inflammation, Subacute      1 (2%)                                                                       
      Submucosa, Foreign Body                                                                 1 (2%)                                
      Submucosa, Inflammation, Chronic, Focal                                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (3)          (1)          (2)                                    
      Cataract                                         1 (100%)     2 (67%)                   1 (50%)                               
      Anterior Chamber, Inflammation, Acute,                                                                                        
          Suppurative                                               1 (33%)                                                         
      Cornea, Cyst                                                                            1 (50%)                               
      Retina, Degeneration                             1 (100%)     2 (67%)                   2 (100%)                              
   Harderian Gland                                                                           (1)                                    
      Inflammation, Chronic, Focal                                                            1 (100%)                              
   Zymbal's Gland                                                               (1)          (1)                                    
      Inflammation, Subacute                                                                  1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05004-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 23:55:48  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      2. MG/KG     4. MG/KG     8. MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Nephropathy, Chronic                            45 (90%)     44 (88%)     48 (96%)     48 (96%)                               
      Cortex, Cyst                                     1 (2%)       1 (2%)       2 (4%)                                             
      Cortex, Cyst, Multiple                                                                  1 (2%)                                
      Cortex, Embolus Bacterial                        1 (2%)                                                                       
      Cortex, Fibrosis, Focal                          1 (2%)                                 1 (2%)                                
      Cortex, Inflammation, Acute, Multifocal,                                                                                      
           Suppurative                                 1 (2%)                                                                       
      Renal Tubule, Mineralization, Multifocal                      1 (2%)                                                          
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Transitional Epithelium, Hyperplasia, Focal                                1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.