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TDMS Study 05004-03 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                               FURAN


NTP Experiment-Test: 05004-03                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/02/94
Route: GAVAGE                                                                                                     Time: 23:57:13




       Facility:  Southern Research Institute

       Chemical CAS #:  110-00-9

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05004-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               FURAN                                           Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 23:57:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      2. MG/KG     4. MG/KG     8. MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund                                          12           17           17           19                                     
    Dead                                               4            1            5           10                                     
    Dosing Accident                                                                           2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           32           28           19                                     
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (50)         (50)         (50)                                   
   Intestine Large, Rectum                            (49)         (50)         (50)         (50)                                   
   Intestine Small, Duodenum                          (49)         (50)         (50)         (50)                                   
      Serosa, Fibrous Histiocytoma                                                            1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Cholangiocarcinoma                                                         2 (4%)       2 (4%)                                
      Cholangiocarcinoma, Multiple                                 49 (98%)     48 (96%)     46 (92%)                               
      Fibrous Histiocytoma                                                                    1 (2%)                                
      Hepatocellular Carcinoma                                                                1 (2%)                                
      Hepatocellular Adenoma                                        1 (2%)       4 (8%)       6 (12%)                               
      Hepatocellular Adenoma, Multiple                              1 (2%)                    1 (2%)                                
      Sarcoma, Metastatic, Tissue NOS                  1 (2%)                                                                       
   Mesentery                                          (8)          (12)         (9)          (13)                                   
      Fibrous Histiocytoma, Multiple                                                          1 (8%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (8%)                                
   Pancreas                                           (50)         (49)         (50)         (50)                                   
      Adenoma                                                                    1 (2%)                                             
      Cholangiocarcinoma, Metastatic, Liver                                                   1 (2%)                                
      Fibrous Histiocytoma                                                                    1 (2%)                                
   Pharynx                                            (1)                                                                           
      Squamous Cell Carcinoma                          1 (100%)                                                                     
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Papilloma                                       1 (2%)                                                          
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
   Tongue                                                                       (1)          (1)                                    
      Squamous Cell Papilloma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05004-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               FURAN                                           Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 23:57:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      2. MG/KG     4. MG/KG     8. MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                    (1)                                    
      Abdominal, Cholangiocarcinoma, Metastatic,                                                                                    
           Liver                                                                              1 (100%)                              
   Heart                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)         (50)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
   Adrenal Gland, Medulla                             (50)         (49)         (50)         (49)                                   
      Pheochromocytoma Malignant                                    1 (2%)                    2 (4%)                                
      Pheochromocytoma Complex                         1 (2%)                                                                       
      Pheochromocytoma Benign                          1 (2%)       3 (6%)       1 (2%)       3 (6%)                                
      Pheochromocytoma Benign, Multiple                1 (2%)                                                                       
   Islets, Pancreatic                                 (49)         (49)         (49)         (50)                                   
      Adenoma                                          1 (2%)                                 1 (2%)                                
   Pituitary Gland                                    (50)         (50)         (49)         (49)                                   
      Pars Distalis, Adenoma                          26 (52%)     26 (52%)     25 (51%)     19 (39%)                               
      Pars Distalis, Adenoma, Multiple                 2 (4%)                                 1 (2%)                                
   Thyroid Gland                                      (50)         (50)         (50)         (49)                                   
      C-Cell, Adenoma                                  8 (16%)      4 (8%)       5 (10%)      2 (4%)                                
      C-Cell, Carcinoma                                1 (2%)       1 (2%)                                                          
      Follicular Cell, Adenocarcinoma                               1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
      Abdominal, Sarcoma                               1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (43)         (48)         (50)         (47)                                   
      Adenoma                                          3 (7%)       7 (15%)      5 (10%)      2 (4%)                                
      Carcinoma                                                                  2 (4%)       1 (2%)                                
      Squamous Cell Papilloma                                       1 (2%)                                                          
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma                                                                    1 (2%)                                
      Granulosa Cell Tumor Malignant                                2 (4%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Adenocarcinoma                                   1 (2%)                                 1 (2%)                                
      Adenoma                                                       1 (2%)                    2 (4%)                                
      Polyp Stromal                                    9 (18%)     12 (24%)     13 (26%)      7 (14%)                               
                                                             Page   3                                                               
NTP Experiment-Test: 05004-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               FURAN                                           Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 23:57:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      2. MG/KG     4. MG/KG     8. MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Polyp Stromal, Multiple                          1 (2%)                    1 (2%)       2 (4%)                                
      Sarcoma Stromal                                  1 (2%)       1 (2%)                                                          
      Cervix, Sarcoma                                                            1 (2%)                                             
   Vagina                                             (2)          (1)          (2)                                                 
      Polyp                                            2 (100%)                                                                     
      Sarcoma                                                       1 (100%)     1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (2)                       (2)                                                 
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma                                                                    1 (2%)                                
   Lymph Node                                         (50)         (50)         (50)         (50)                                   
      Axillary, Adenocarcinoma, Metastatic,                                                                                         
          Mammary Gland                                             1 (2%)                                                          
   Lymph Node, Bronchial                              (27)         (43)         (42)         (30)                                   
      Fibrous Histiocytoma                                                                    1 (3%)                                
   Lymph Node, Mandibular                             (47)         (48)         (47)         (46)                                   
      Fibrous Histiocytoma                                                                    1 (2%)                                
   Lymph Node, Mediastinal                            (48)         (48)         (49)         (49)                                   
      Fibrous Histiocytoma                                                                    1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
      Pancreatic, Cholangiocarcinoma, Metastatic,                                                                                   
           Liver                                                                              1 (2%)                                
   Lymph Node, Mesenteric                             (48)         (50)         (50)         (48)                                   
      Fibrous Histiocytoma                                                                    1 (2%)                                
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma                                                                    1 (2%)                                
   Thymus                                             (47)         (46)         (47)         (43)                                   
      Fibrous Histiocytoma                                                                    1 (2%)                                
      Mediastinum, Carcinoma, Metastatic, Zymbal's                                                                                  
          Gland                                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (49)         (50)                                   
      Adenocarcinoma                                   1 (2%)       2 (4%)       3 (6%)       1 (2%)                                
      Adenocarcinoma, Multiple                                      1 (2%)                                                          
      Adenoma                                                                    2 (4%)       1 (2%)                                
      Fibroadenoma                                    14 (28%)     13 (26%)     16 (33%)     12 (24%)                               
      Fibroadenoma, Multiple                           1 (2%)       4 (8%)       2 (4%)       2 (4%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Fibroma                                                       1 (2%)                                                          
      Keratoacanthoma                                                            1 (2%)                                             
      Squamous Cell Papilloma                                       1 (2%)                                                          
                                                             Page   4                                                               
NTP Experiment-Test: 05004-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               FURAN                                           Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 23:57:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      2. MG/KG     4. MG/KG     8. MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (1)                       (1)                                    
      Rhabdomyosarcoma                                              1 (100%)                                                        
      Diaphragm, Hepatocellular Carcinoma,                                                                                          
          Metastatic, Liver                                                                   1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Astrocytoma Malignant                                                                   1 (2%)                                
      Fibrous Histiocytoma                                                                    1 (2%)                                
      Glioma Malignant                                              1 (2%)                                                          
      Granular Cell Tumor Malignant                                              1 (2%)                                             
      Oligodendroglioma Malignant                                   1 (2%)                                                          
   Spinal Cord                                        (1)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Carcinoma, Metastatic, Zymbal's Gland                                      1 (2%)                                             
      Fibrous Histiocytoma                                                                    1 (2%)                                
      Sarcoma, Metastatic, Tissue NOS                  1 (2%)                                                                       
      Sarcoma Stromal, Metastatic, Uterus              1 (2%)                                                                       
      Mediastinum, Fibrous Histiocytoma                                                       1 (2%)                                
      Venule, Mediastinum, Cholangiocarcinoma,                                                                                      
           Metastatic, Liver                                                                  1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Squamous Cell Papilloma                                                    1 (2%)                                             
   Trachea                                            (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (2)                                                              
      Fibrosarcoma                                                  1 (50%)                                                         
      Pinna, Sarcoma                                                1 (50%)                                                         
   Harderian Gland                                    (2)                       (1)          (1)                                    
   Lacrimal Gland                                     (1)                       (1)                                                 
      Squamous Cell Carcinoma, Metastatic, Pharynx     1 (100%)                                                                     
   Zymbal's Gland                                     (1)                       (1)                                                 
      Carcinoma                                        1 (100%)                  1 (100%)                                           
                                                             Page   5                                                               
NTP Experiment-Test: 05004-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               FURAN                                           Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 23:57:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      2. MG/KG     4. MG/KG     8. MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma                                                                    1 (2%)                                
      Sarcoma                                                                    1 (2%)                                             
   Urinary Bladder                                    (49)         (50)         (49)         (50)                                   
      Transitional Epithelium, Papilloma                                                      3 (6%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                             8 (16%)      9 (18%)     17 (34%)     21 (42%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   6                                                               
NTP Experiment-Test: 05004-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               FURAN                                           Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 23:57:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      2. MG/KG     4. MG/KG     8. MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            45          50          50          50                                       
     Total Primary Neoplasms                           86         149         157         156                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 42          41          41          37                                       
     Total Benign Neoplasms                            69          76          78          64                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              16          50          50          50                                       
     Total Malignant Neoplasms                         17          73          79          92                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           1           1           3                                       
     Total Metastatic Neoplasm                          4           1           2           9                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 05004-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               FURAN                                           Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 23:57:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      2. MG/KG     4. MG/KG     8. MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Dosing Accident                                    6            5            4            1                                     
    Dead                                               1            4            3            5                                     
    Moribund                                          10           13           17           28                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           28           26           16                                     
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (49)         (50)         (50)         (50)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Cholangiocarcinoma, Multiple                                 43 (86%)     48 (96%)     49 (98%)                               
      Hepatocellular Carcinoma                                      1 (2%)       6 (12%)     17 (34%)                               
      Hepatocellular Carcinoma, Multiple                                                      1 (2%)                                
      Hepatocellular Adenoma                           1 (2%)       3 (6%)      16 (32%)     17 (34%)                               
      Hepatocellular Adenoma, Multiple                              1 (2%)       2 (4%)      10 (20%)                               
   Mesentery                                          (5)          (12)         (12)         (14)                                   
      Cholangiocarcinoma, Metastatic, Liver                                                   2 (14%)                               
   Pancreas                                           (50)         (50)         (50)         (49)                                   
      Adenocarcinoma                                                             1 (2%)                                             
      Adenoma                                          4 (8%)       6 (12%)      9 (18%)      4 (8%)                                
      Adenoma, Multiple                                2 (4%)       3 (6%)       1 (2%)       2 (4%)                                
      Mixed Tumor Benign                                            1 (2%)                                                          
   Pharynx                                                         (1)          (1)                                                 
      Squamous Cell Papilloma                                       1 (100%)                                                        
   Salivary Glands                                    (49)         (50)         (50)         (49)                                   
   Stomach, Forestomach                               (50)         (49)         (50)         (50)                                   
   Stomach, Glandular                                 (50)         (49)         (50)         (50)                                   
   Tongue                                             (1)                       (2)                                                 
      Squamous Cell Papilloma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05004-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               FURAN                                           Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 23:57:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      2. MG/KG     4. MG/KG     8. MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)         (50)                                   
      Adenoma                                                       1 (2%)                                                          
   Adrenal Gland, Medulla                             (50)         (47)         (48)         (49)                                   
      Pheochromocytoma Malignant                       1 (2%)                    3 (6%)                                             
      Pheochromocytoma Benign                          7 (14%)      4 (9%)       8 (17%)      8 (16%)                               
      Pheochromocytoma Benign, Multiple                1 (2%)                    1 (2%)       2 (4%)                                
   Islets, Pancreatic                                 (50)         (50)         (50)         (49)                                   
      Adenoma                                          3 (6%)       2 (4%)       1 (2%)       1 (2%)                                
      Adenoma, Multiple                                3 (6%)                                                                       
      Carcinoma                                        1 (2%)                                                                       
   Parathyroid Gland                                  (46)         (47)         (49)         (43)                                   
      Adenoma                                                                                 1 (2%)                                
   Pituitary Gland                                    (49)         (50)         (49)         (49)                                   
      Pars Distalis, Adenoma                          11 (22%)     11 (22%)     17 (35%)     11 (22%)                               
      Pars Distalis, Carcinoma                                                                1 (2%)                                
   Thyroid Gland                                      (48)         (50)         (50)         (48)                                   
      C-Cell, Adenoma                                  6 (13%)      6 (12%)      1 (2%)       4 (8%)                                
      C-Cell, Carcinoma                                1 (2%)       1 (2%)       2 (4%)                                             
      Follicular Cell, Carcinoma                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
   Preputial Gland                                    (49)         (50)         (46)         (48)                                   
      Adenoma                                          1 (2%)       2 (4%)       4 (9%)       3 (6%)                                
      Carcinoma                                                     4 (8%)                                                          
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Bilateral, Adenoma                                                                      1 (2%)                                
   Prostate                                           (50)         (50)         (50)         (49)                                   
   Seminal Vesicle                                    (1)                       (4)          (1)                                    
   Testes                                             (50)         (50)         (50)         (50)                                   
      Interstitial Cell, Adenoma                       3 (6%)       2 (4%)       1 (2%)       2 (4%)                                
      Interstitial Cell, Adenoma, Multiple            41 (82%)     36 (72%)     39 (78%)     43 (86%)                               
      Interstitial Tissue, Adenoma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05004-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               FURAN                                           Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 23:57:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      2. MG/KG     4. MG/KG     8. MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                                                        (1)          (1)                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
   Lymph Node                                         (50)         (50)         (50)         (50)                                   
   Lymph Node, Bronchial                              (34)         (40)         (35)         (27)                                   
   Lymph Node, Mandibular                             (48)         (45)         (48)         (48)                                   
   Lymph Node, Mediastinal                            (48)         (45)         (48)         (45)                                   
   Lymph Node, Mesenteric                             (46)         (50)         (49)         (49)                                   
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Sarcoma                                                                                 2 (4%)                                
   Thymus                                             (48)         (49)         (46)         (42)                                   
      Mediastinum, Schwannoma Malignant                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (50)         (50)         (50)                                   
      Adenocarcinoma                                                1 (2%)                                                          
      Fibroadenoma                                     4 (8%)       3 (6%)       1 (2%)       1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basal Cell Adenoma                               1 (2%)                                                                       
      Basal Cell Carcinoma                                          1 (2%)                    1 (2%)                                
      Fibroma                                                                    1 (2%)                                             
      Keratoacanthoma                                               3 (6%)       5 (10%)      2 (4%)                                
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Squamous Cell Papilloma                          1 (2%)       2 (4%)                    1 (2%)                                
      Subcutaneous Tissue, Fibroma                                  3 (6%)       4 (8%)       3 (6%)                                
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                    2 (4%)                                             
      Subcutaneous Tissue, Fibrous Histiocytoma                     1 (2%)                                                          
      Subcutaneous Tissue, Lipoma                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (1)                       (1)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Pituitary Gland                                                  1 (2%)                                
      Glioma Malignant                                                           1 (2%)                                             
      Granular Cell Tumor Benign                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  10                                                               
NTP Experiment-Test: 05004-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               FURAN                                           Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 23:57:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      2. MG/KG     4. MG/KG     8. MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma                                             2 (4%)                                             
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                                          1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic,                                                                                          
          Preputial Gland                              1 (2%)                                                                       
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      1 (2%)                                             
   Nose                                               (50)         (50)         (50)         (50)                                   
      Nasolacrimal Duct, Squamous Cell Carcinoma                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                               (1)          (1)                                    
      Carcinoma                                                                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                             8 (16%)     11 (22%)     17 (34%)     25 (50%)                               
      Mesothelioma Malignant                           1 (2%)       1 (2%)       3 (6%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  11                                                               
NTP Experiment-Test: 05004-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               FURAN                                           Date: 09/02/94  
Route: GAVAGE                                                                                                     Time: 23:57:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      2. MG/KG     4. MG/KG     8. MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            46          45          48          49                                       
     Total Primary Neoplasms                          108         156         198         217                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 46          42          46          47                                       
     Total Benign Neoplasms                            94          90         112         116                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              14          44          48          49                                       
     Total Malignant Neoplasms                         14          66          86         101                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1                       3           3                                       
     Total Metastatic Neoplasm                          1                       3           3                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  12                                                               
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