National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3116

TDMS Study 05006-06 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                            BENZALDEHYDE


NTP Experiment-Test: 05006-06                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/03/94
Route: GAVAGE                                                                                                     Time: 10:23:52




       Facility:  Southern Research Institute

       Chemical CAS #:  100-52-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05006-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 10:23:52  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      300.         600.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          11           13            7                                                  
    Dead                                               7            8            8                                                  
    Accidently Killed                                  1            1                                                               
    Accident                                           1            1                                                               
  Survivors                                                                                                                         
    Dead                                                                         1                                                  
    Terminal Sacrifice                                30           27           34                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (45)                      (49)                                                
      Inflammation, Chronic                            1 (2%)                                                                       
   Liver                                              (50)         (8)          (49)                                                
      Focal Cellular Change                            1 (2%)                                                                       
      Hematopoietic Cell Proliferation, Multifocal     2 (4%)                    4 (8%)                                             
      Hemorrhage, Multifocal                           2 (4%)                                                                       
      Necrosis, Multifocal                             3 (6%)                    2 (4%)                                             
      Vacuolization Cytoplasmic, Diffuse               1 (2%)       1 (13%)                                                         
      Vacuolization Cytoplasmic, Focal                              1 (13%)                                                         
      Centrilobular, Necrosis                          1 (2%)                                                                       
      Sinusoid, Infiltration Cellular,                                                                                              
          Polymorphonuclear                            5 (10%)                   1 (2%)                                             
   Mesentery                                          (11)         (5)          (6)                                                 
      Abscess                                          1 (9%)                    1 (17%)                                            
      Inflammation, Acute, Suppurative                 4 (36%)                   2 (33%)                                            
      Fat, Necrosis, Focal                             2 (18%)      3 (60%)      1 (17%)                                            
      Fat, Necrosis, Multifocal                                     1 (20%)                                                         
   Salivary Glands                                    (49)         (1)          (49)                                                
      Hemorrhage                                                    1 (100%)                                                        
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Cyst                                                                       1 (2%)                                             
      Hyperplasia, Focal                               7 (14%)     11 (22%)     13 (26%)                                            
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Hyperplasia, Multifocal                          1 (2%)       4 (8%)      11 (22%)                                            
      Inflammation, Acute, Focal, Suppurative          4 (8%)       7 (14%)      4 (8%)                                             
      Inflammation, Acute, Multifocal, Suppurative                  1 (2%)       3 (6%)                                             
      Inflammation, Focal, Subacute                                 1 (2%)                                                          
      Mineralization                                                1 (2%)                                                          
      Ulcer                                            2 (4%)       1 (2%)       3 (6%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)                                                
      Mineralization                                   1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05006-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 10:23:52  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      300.         600.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Tooth                                              (1)                                                                           
      Dysplasia                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)                      (50)                                                
      Cyst                                             2 (4%)                                                                       
      Degeneration, Fatty, Focal                                                 1 (2%)                                             
      Hyperplasia, Focal                               1 (2%)                                                                       
      Hypertrophy, Focal                                                         1 (2%)                                             
      Spindle Cell, Hyperplasia                        1 (2%)                                                                       
   Adrenal Gland, Medulla                             (50)                      (50)                                                
      Hyperplasia, Focal                               2 (4%)                    1 (2%)                                             
      Bilateral, Infiltration Cellular,                                                                                             
          Polymorphonuclear                                                      1 (2%)                                             
   Parathyroid Gland                                  (42)                      (47)                                                
      Cyst                                                                       1 (2%)                                             
   Pituitary Gland                                    (47)         (3)          (48)                                                
      Pars Distalis, Angiectasis                       1 (2%)                    4 (8%)                                             
      Pars Distalis, Cyst                              1 (2%)                                                                       
      Pars Distalis, Hyperplasia, Focal                3 (6%)       1 (33%)      4 (8%)                                             
   Thyroid Gland                                      (49)                      (49)                                                
      C-Cell, Hyperplasia, Focal                       1 (2%)                                                                       
      Follicle, Cyst                                                             3 (6%)                                             
      Follicle, Degeneration, Cystic                                             4 (8%)                                             
      Follicular Cell, Hyperplasia, Focal              2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (47)         (14)         (44)                                                
      Abscess                                          4 (9%)       6 (43%)      1 (2%)                                             
      Abscess, Multiple                                4 (9%)       2 (14%)      6 (14%)                                            
      Cyst                                            10 (21%)      6 (43%)      9 (20%)                                            
      Inflammation, Chronic                                                      1 (2%)                                             
   Uterus                                             (50)         (29)         (50)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05006-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 10:23:52  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      300.         600.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Hydrometra                                       6 (12%)      6 (21%)      4 (8%)                                             
      Hyperplasia, Cystic                             45 (90%)     27 (93%)     39 (78%)                                            
      Inflammation, Acute, Suppurative                 6 (12%)      2 (7%)       6 (12%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (4)          (4)          (2)                                                 
      Leukocytosis                                                  1 (25%)                                                         
      Polychromasia                                    3 (75%)                                                                      
   Bone Marrow                                        (50)                      (50)                                                
      Myelofibrosis                                    2 (4%)                    2 (4%)                                             
      Myeloid Cell, Hyperplasia                                                  2 (4%)                                             
   Lymph Node                                         (50)         (10)         (50)                                                
      Bronchial, Inflammation, Acute, Suppurative                                1 (2%)                                             
      Deep Cervical, Hyperplasia                                                 1 (2%)                                             
      Iliac, Ectasia                                   1 (2%)                                                                       
      Iliac, Hyperplasia                                            3 (30%)      1 (2%)                                             
      Iliac, Inflammation, Acute, Suppurative                       1 (10%)                                                         
      Mediastinal, Hyperplasia                         1 (2%)       1 (10%)                                                         
      Mediastinal, Inflammation, Acute, Suppurative    1 (2%)                    1 (2%)                                             
      Renal, Hyperplasia                               4 (8%)       2 (20%)      2 (4%)                                             
   Lymph Node, Mandibular                             (48)         (3)          (47)                                                
      Angiectasis                                      1 (2%)                                                                       
      Hyperplasia                                      4 (8%)                    1 (2%)                                             
   Lymph Node, Mesenteric                             (47)         (5)          (45)                                                
      Angiectasis                                      1 (2%)                    1 (2%)                                             
      Hyperplasia                                      2 (4%)                    2 (4%)                                             
   Spleen                                             (50)         (18)         (49)                                                
      Atrophy                                                       1 (6%)                                                          
      Fibrosis, Focal                                                            1 (2%)                                             
      Hematopoietic Cell Proliferation                13 (26%)      8 (44%)      7 (14%)                                            
      Hemorrhage, Focal                                                          1 (2%)                                             
      Hyperplasia, Focal, Lymphoid                                  1 (6%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)                    3 (6%)                                             
      Necrosis, Focal                                  1 (2%)                    1 (2%)                                             
   Thymus                                             (47)                      (47)                                                
      Atrophy                                          2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (2)          (49)                                                
      Duct, Cyst                                       4 (8%)                    3 (6%)                                             
   Skin                                               (50)         (48)         (50)                                                
      Subcutaneous Tissue, Hemorrhage                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05006-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 10:23:52  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      300.         600.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (1)          (50)                                                
      Cranium, Hypertrophy, Focal                                   1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (1)          (50)                                                
      Compression                                      1 (2%)       1 (100%)                                                        
      Hemorrhage, Multifocal                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (4)          (50)                                                
      Congestion                                       1 (2%)                                                                       
      Hemorrhage, Multifocal                           1 (2%)                                                                       
      Hyperplasia, Focal, Lymphoid                     1 (2%)                                                                       
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia, Focal          2 (4%)                                                                       
      Mediastinum, Inflammation, Acute, Suppurative    3 (6%)                    1 (2%)                                             
   Nose                                               (50)                      (50)                                                
      Foreign Body                                     1 (2%)                    2 (4%)                                             
      Fungus                                                                     1 (2%)                                             
      Inflammation, Acute, Suppurative                 1 (2%)                    1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Subacute                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (2)          (49)                                                
      Hydronephrosis                                   2 (4%)                                                                       
      Metaplasia, Focal, Osseous                                                 1 (2%)                                             
      Capsule, Inflammation, Acute, Suppurative                                  1 (2%)                                             
      Glomerulus, Inflammation, Chronic                2 (4%)                    1 (2%)                                             
      Papilla, Necrosis                                1 (2%)                                                                       
      Renal Tubule, Atrophy, Multifocal                                          1 (2%)                                             
      Renal Tubule, Degeneration, Multifocal                                     2 (4%)                                             
      Renal Tubule, Dilatation, Multifocal             3 (6%)                    1 (2%)                                             
      Renal Tubule, Nuclear Alteration, Multifocal                               2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05006-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 10:23:52  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      300.         600.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Renal Tubule, Regeneration, Multifocal           2 (4%)                    2 (4%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05006-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 10:23:52  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               5            4            3                                                  
    Moribund                                           9           11           13                                                  
    Gavage Death                                       3            2            1                                                  
    Dosing Accident                                    1                         1                                                  
    Natural Death                                                                1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           33           31                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (2)          (50)                                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Muscularis, Degeneration                         1 (2%)                                                                       
   Gallbladder                                        (45)                      (46)                                                
      Epithelium, Hyperplasia, Focal                                             1 (2%)                                             
   Intestine Small, Jejunum                           (50)         (2)          (49)                                                
      Diverticulum                                     1 (2%)                                                                       
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
      Epithelium, Hyperplasia, Focal                   1 (2%)                                                                       
   Liver                                              (50)         (18)         (50)                                                
      Angiectasis, Focal                                                         1 (2%)                                             
      Cyst                                             2 (4%)                                                                       
      Focal Cellular Change                            1 (2%)                    1 (2%)                                             
      Hematopoietic Cell Proliferation, Multifocal                               1 (2%)                                             
      Hemorrhage, Focal                                                          1 (2%)                                             
      Hepatodiaphragmatic Nodule                                    1 (6%)                                                          
      Hyperplasia, Focal, Lymphoid                                  1 (6%)                                                          
      Necrosis, Focal                                  1 (2%)                    2 (4%)                                             
      Necrosis, Multifocal                             1 (2%)                    2 (4%)                                             
      Vacuolization Cytoplasmic, Diffuse                            1 (6%)                                                          
      Vacuolization Cytoplasmic, Focal                              3 (17%)                                                         
   Mesentery                                          (5)          (5)          (2)                                                 
      Hemorrhage, Focal                                                          1 (50%)                                            
      Fat, Necrosis, Focal                             4 (80%)      3 (60%)      1 (50%)                                            
      Fat, Necrosis, Multifocal                                     1 (20%)                                                         
   Pancreas                                           (50)         (2)          (49)                                                
      Atrophy, Focal                                   2 (4%)                    1 (2%)                                             
      Cyst                                             2 (4%)                                                                       
   Stomach, Forestomach                               (50)         (49)         (50)                                                
      Cyst                                                          2 (4%)       4 (8%)                                             
      Hyperplasia, Focal                               7 (14%)      6 (12%)     15 (30%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05006-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 10:23:52  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hyperplasia, Multifocal                                       2 (4%)       1 (2%)                                             
      Infiltration Cellular, Mast Cell                                           1 (2%)                                             
      Inflammation, Acute, Focal, Suppurative          3 (6%)       5 (10%)      7 (14%)                                            
      Inflammation, Chronic, Focal                                  1 (2%)                                                          
      Ulcer                                            1 (2%)                    4 (8%)                                             
   Stomach, Glandular                                 (50)         (49)         (50)                                                
      Inflammation, Acute, Focal, Suppurative                       1 (2%)                                                          
   Tongue                                                          (1)                                                              
      Ectopic Tissue                                                1 (100%)                                                        
   Tooth                                              (20)         (1)          (14)                                                
      Dysplasia                                       20 (100%)     1 (100%)    14 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (1)          (50)                                                
      Artery, Inflammation, Subacute                                             1 (2%)                                             
      Valve, Inflammation, Subacute                                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)                      (50)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia, Focal                               2 (4%)                    3 (6%)                                             
      Necrosis                                                                   1 (2%)                                             
      Spindle Cell, Hyperplasia                                                  1 (2%)                                             
   Adrenal Gland, Medulla                             (49)                      (50)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia, Focal                                                         2 (4%)                                             
      Necrosis                                                                   1 (2%)                                             
   Pituitary Gland                                    (44)                      (47)                                                
      Pars Distalis, Cyst                                                        1 (2%)                                             
   Thyroid Gland                                      (49)                      (49)                                                
      Follicle, Cyst                                   1 (2%)                                                                       
      Follicle, Degeneration, Cystic                   3 (6%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05006-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 10:23:52  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                               (1)                                                              
      Dilatation                                                    1 (100%)                                                        
   Epididymis                                         (50)                      (50)                                                
      Inflammation, Chronic, Focal                                               1 (2%)                                             
   Penis                                                           (1)                                                              
      Hemorrhage                                                    1 (100%)                                                        
      Inflammation, Acute, Suppurative                              1 (100%)                                                        
      Necrosis                                                      1 (100%)                                                        
   Preputial Gland                                    (2)          (5)          (7)                                                 
      Inflammation, Acute, Suppurative                              2 (40%)      4 (57%)                                            
      Duct, Cyst                                       2 (100%)     4 (80%)      4 (57%)                                            
   Seminal Vesicle                                    (2)          (5)          (5)                                                 
      Dilatation                                       2 (100%)     5 (100%)     3 (60%)                                            
      Inflammation, Chronic                                                      1 (20%)                                            
   Testes                                             (50)                      (50)                                                
      Atrophy                                                                    4 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (1)          (2)          (2)                                                 
      Leukocytosis                                                  1 (50%)                                                         
      Polychromasia                                                 1 (50%)      2 (100%)                                           
   Bone Marrow                                        (50)                      (50)                                                
      Myeloid Cell, Hyperplasia                                                  1 (2%)                                             
   Lymph Node, Mesenteric                             (46)         (5)          (48)                                                
      Angiectasis                                      6 (13%)      2 (40%)      6 (13%)                                            
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia                                      1 (2%)       1 (20%)                                                         
   Spleen                                             (50)         (7)          (50)                                                
      Atrophy                                          1 (2%)       1 (14%)      2 (4%)                                             
      Congestion                                                    1 (14%)                                                         
      Developmental Malformation                                                 1 (2%)                                             
      Hematopoietic Cell Proliferation                 9 (18%)      2 (29%)     10 (20%)                                            
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Thymus                                             (41)                      (45)                                                
      Cyst                                             2 (5%)                                                                       
      Hyperplasia                                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (26)         (50)                                                
      Abscess                                                                    1 (2%)                                             
      Alopecia                                                                   1 (2%)                                             
      Cyst Epithelial Inclusion                                     1 (4%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05006-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 10:23:52  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Developmental Malformation                                                 2 (4%)                                             
      Edema, Focal                                     1 (2%)                                                                       
      Fibrosis, Focal                                  2 (4%)       2 (8%)       7 (14%)                                            
      Fibrosis, Multifocal                                                       1 (2%)                                             
      Foreign Body, Focal                              1 (2%)                                                                       
      Inflammation, Acute, Focal, Suppurative                       1 (4%)                                                          
      Inflammation, Focal, Subacute                    1 (2%)                    2 (4%)                                             
      Mineralization, Focal                            1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (2)          (1)          (2)                                                 
      Hemorrhage                                                    1 (100%)                                                        
      Artery, Inflammation, Subacute                                             1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)                      (50)                                                
      Compression                                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (14)         (50)                                                
      Congestion                                       2 (4%)                                                                       
      Foreign Body                                                  1 (7%)       1 (2%)                                             
      Hemorrhage, Focal                                             1 (7%)                                                          
      Hemorrhage, Multifocal                                        1 (7%)                                                          
      Infiltration Cellular, Histiocyte                1 (2%)       2 (14%)      3 (6%)                                             
      Alveolar Epithelium, Hyperplasia, Focal          1 (2%)       3 (21%)      4 (8%)                                             
      Fat, Mediastinum, Necrosis, Focal                1 (2%)                                                                       
      Mediastinum, Foreign Body                        4 (8%)                    1 (2%)                                             
      Mediastinum, Hemorrhage                          1 (2%)                                                                       
      Mediastinum, Inflammation, Acute, Suppurative    1 (2%)                    1 (2%)                                             
   Nose                                               (50)                      (50)                                                
      Foreign Body                                    10 (20%)                  13 (26%)                                            
      Fungus                                           1 (2%)                                                                       
      Inflammation, Acute, Suppurative                11 (22%)                  14 (28%)                                            
      Nasolacrimal Duct, Inflammation, Acute,                                                                                       
          Suppurative                                  3 (6%)                                                                       
   Trachea                                            (50)         (1)          (50)                                                
      Perforation                                                   1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05006-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 10:23:52  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (2)                                                              
      Cornea, Fibrosis                                              1 (50%)                                                         
      Cornea, Inflammation, Chronic                                 1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (2)          (50)                                                
      Fibrosis, Focal                                                            1 (2%)                                             
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
      Metaplasia, Focal, Osseous                       1 (2%)                    3 (6%)                                             
      Mineralization, Multifocal                                                 1 (2%)                                             
      Cortex, Cyst                                                               3 (6%)                                             
      Glomerulus, Amyloid Deposition                   1 (2%)                                                                       
      Papilla, Necrosis                                                          1 (2%)                                             
      Renal Tubule, Degeneration, Multifocal           3 (6%)                    4 (8%)                                             
      Renal Tubule, Dilatation, Multifocal                          1 (50%)      2 (4%)                                             
      Renal Tubule, Necrosis, Multifocal                            1 (50%)      1 (2%)                                             
      Renal Tubule, Regeneration, Multifocal                        1 (50%)      1 (2%)                                             
   Urinary Bladder                                    (50)         (2)          (50)                                                
      Hemorrhage, Focal                                             1 (50%)                                                         
      Inflammation, Subacute                                        1 (50%)                                                         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
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