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TDMS Study 05006-06 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                            BENZALDEHYDE


NTP Experiment-Test: 05006-06                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/03/94
Route: GAVAGE                                                                                                     Time: 10:23:53




       Facility:  Southern Research Institute

       Chemical CAS #:  100-52-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05006-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 10:23:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      300.         600.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          11           13            7                                                  
    Dead                                               7            8            8                                                  
    Accidently Killed                                  1            1                                                               
    Accident                                           1            1                                                               
  Survivors                                                                                                                         
    Dead                                                                         1                                                  
    Terminal Sacrifice                                30           27           34                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (45)                      (49)                                                
      Adenocarcinoma, Metastatic, Uterus               1 (2%)                                                                       
   Intestine Small, Jejunum                           (48)         (1)          (49)                                                
      Polyp Adenomatous                                             1 (100%)                                                        
   Liver                                              (50)         (8)          (49)                                                
      Hepatocellular Carcinoma                         1 (2%)       2 (25%)      1 (2%)                                             
      Hepatocellular Adenoma                           1 (2%)       1 (13%)      4 (8%)                                             
      Hepatocellular Adenoma, Multiple                              1 (13%)                                                         
      Histiocytic Sarcoma                              2 (4%)                                                                       
   Mesentery                                          (11)         (5)          (6)                                                 
      Adenocarcinoma, Metastatic, Uterus               1 (9%)                                                                       
      Histiocytic Sarcoma                              1 (9%)                                                                       
   Pancreas                                           (48)                      (48)                                                
   Salivary Glands                                    (49)         (1)          (49)                                                
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Squamous Cell Papilloma                                       5 (10%)      4 (8%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)                      (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05006-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 10:23:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      300.         600.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)                      (50)                                                
      Adenoma                                          1 (2%)                                                                       
   Adrenal Gland, Medulla                             (50)                      (50)                                                
      Pheochromocytoma Benign                          1 (2%)                                                                       
   Pituitary Gland                                    (47)         (3)          (48)                                                
      Pars Distalis, Adenoma                           5 (11%)      1 (33%)      2 (4%)                                             
   Thyroid Gland                                      (49)                      (49)                                                
      Follicular Cell, Adenoma                         1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (47)         (14)         (44)                                                
      Adenoma                                          1 (2%)                                                                       
   Uterus                                             (50)         (29)         (50)                                                
      Adenocarcinoma                                   1 (2%)                    1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Leiomyoma                                                     1 (3%)                                                          
      Polyp Stromal                                    1 (2%)                    1 (2%)                                             
      Sarcoma Stromal                                               2 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (4)          (4)          (2)                                                 
   Bone Marrow                                        (50)                      (50)                                                
      Hemangiosarcoma                                  1 (2%)                                                                       
   Lymph Node                                         (50)         (10)         (50)                                                
      Axillary, Adenocarcinoma, Metastatic,                                                                                         
          Mammary Gland                                1 (2%)                                                                       
      Iliac, Histiocytic Sarcoma                       1 (2%)                                                                       
      Mediastinal, Adenocarcinoma, Metastatic,                                                                                      
           Uterus                                      1 (2%)                                                                       
      Mediastinal, Histiocytic Sarcoma                 1 (2%)                                                                       
      Renal, Histiocytic Sarcoma                       1 (2%)                                                                       
   Lymph Node, Mandibular                             (48)         (3)          (47)                                                
   Lymph Node, Mesenteric                             (47)         (5)          (45)                                                
      Histiocytic Sarcoma                              2 (4%)                                                                       
   Spleen                                             (50)         (18)         (49)                                                
      Hemangiosarcoma                                  1 (2%)                    1 (2%)                                             
      Hemangiosarcoma, Metastatic, Skin                                          1 (2%)                                             
                                                             Page   3                                                               
NTP Experiment-Test: 05006-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 10:23:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      300.         600.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Thymus                                             (47)                      (47)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (2)          (49)                                                
      Adenocarcinoma                                   2 (4%)       2 (100%)     2 (4%)                                             
   Skin                                               (50)         (48)         (50)                                                
      Squamous Cell Papilloma                                       1 (2%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                                                          
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)          (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (1)          (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (4)          (50)                                                
      Adenocarcinoma, Metastatic, Mammary Gland        1 (2%)                    1 (2%)                                             
      Adenocarcinoma, Metastatic, Uterus               1 (2%)                                                                       
      Alveolar/Bronchiolar Adenoma                                  1 (25%)                                                         
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Histiocytic Sarcoma                              2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (2)          (1)          (2)                                                 
      Adenoma                                          1 (50%)      1 (100%)     1 (50%)                                            
      Carcinoma                                        1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (2)          (49)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Urinary Bladder                                    (50)                      (48)                                                
      Leiomyosarcoma, Metastatic, Uterus               1 (2%)                                                                       
                                                             Page   4                                                               
NTP Experiment-Test: 05006-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 10:23:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      300.         600.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                              2 (4%)                                                                       
      Lymphoma Malignant                                                         1 (2%)                                             
      Lymphoma Malignant Histiocytic                   1 (2%)                    1 (2%)                                             
      Lymphoma Malignant Lymphocytic                   4 (8%)       2 (4%)       6 (12%)                                            
      Lymphoma Malignant Mixed                         8 (16%)      7 (14%)      8 (16%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05006-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 10:23:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      300.         600.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            29          23          27                                                   
     Total Primary Neoplasms                           35          29          36                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 12          10          10                                                   
     Total Benign Neoplasms                            12          13          13                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          16          21                                                   
     Total Malignant Neoplasms                         23          16          23                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4                       2                                                   
     Total Metastatic Neoplasm                          8                       2                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05006-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 10:23:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               5            4            3                                                  
    Moribund                                           9           11           13                                                  
    Gavage Death                                       3            2            1                                                  
    Dosing Accident                                    1                         1                                                  
    Natural Death                                                                1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           33           31                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (50)         (2)          (49)                                                
      Adenocarcinoma                                   1 (2%)       1 (50%)      1 (2%)                                             
      Polyp Adenomatous                                                          1 (2%)                                             
   Liver                                              (50)         (18)         (50)                                                
      Fibrosarcoma, Metastatic, Spleen                              1 (6%)                                                          
      Hemangioma                                       1 (2%)                                                                       
      Hemangiosarcoma                                                            1 (2%)                                             
      Hepatocellular Carcinoma                        12 (24%)      6 (33%)      7 (14%)                                            
      Hepatocellular Adenoma                           8 (16%)      6 (33%)     13 (26%)                                            
      Hepatocellular Adenoma, Multiple                                           1 (2%)                                             
      Histiocytic Sarcoma                                           1 (6%)                                                          
   Mesentery                                          (5)          (5)          (2)                                                 
      Fibrosarcoma, Metastatic, Spleen                              1 (20%)                                                         
      Hemangiosarcoma                                  1 (20%)                                                                      
   Pancreas                                           (50)         (2)          (49)                                                
      Fibrosarcoma, Metastatic, Spleen                              1 (50%)                                                         
   Stomach, Forestomach                               (50)         (49)         (50)                                                
      Squamous Cell Papilloma                          1 (2%)       2 (4%)       5 (10%)                                            
   Stomach, Glandular                                 (50)         (49)         (50)                                                
      Sarcoma                                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05006-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 10:23:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)                      (50)                                                
      Spindle Cell, Adenoma                                                      2 (4%)                                             
   Adrenal Gland, Medulla                             (49)                      (50)                                                
      Pheochromocytoma Benign                          2 (4%)                    2 (4%)                                             
   Islets, Pancreatic                                 (50)                      (49)                                                
      Adenoma                                          1 (2%)                    1 (2%)                                             
   Pituitary Gland                                    (44)                      (47)                                                
      Pars Distalis, Adenoma                           1 (2%)                    1 (2%)                                             
   Thyroid Gland                                      (49)                      (49)                                                
      Follicular Cell, Adenoma                         2 (4%)                    1 (2%)                                             
      Follicular Cell, Carcinoma                                                 2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Prostate                                           (49)                      (50)                                                
   Testes                                             (50)                      (50)                                                
      Interstitial Cell, Adenoma                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (50)         (5)          (50)                                                
   Lymph Node, Mandibular                             (46)                      (47)                                                
   Lymph Node, Mesenteric                             (46)         (5)          (48)                                                
      Fibrosarcoma, Metastatic, Spleen                              1 (20%)                                                         
      Histiocytic Sarcoma                                           1 (20%)                                                         
   Spleen                                             (50)         (7)          (50)                                                
      Fibrosarcoma                                                  1 (14%)                                                         
      Hemangiosarcoma                                               1 (14%)      1 (2%)                                             
      Hemangiosarcoma, Metastatic, Mesentery           1 (2%)                                                                       
   Thymus                                             (41)                      (45)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (26)         (50)                                                
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     2 (4%)       1 (4%)       3 (6%)                                             
      Subcutaneous Tissue, Fibrosarcoma                3 (6%)       3 (12%)      4 (8%)                                             
      Subcutaneous Tissue, Sarcoma                                               1 (2%)                                             
                                                             Page   8                                                               
NTP Experiment-Test: 05006-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 10:23:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Sarcoma, Multiple                        1 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (2)          (1)          (2)                                                 
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (50%)                                                                      
      Hemangiosarcoma, Metastatic, Mesentery           1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (14)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     6 (12%)      2 (14%)      1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   3 (6%)       2 (14%)      5 (10%)                                            
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Skin                                             2 (4%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)                    1 (2%)                                             
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                            1 (2%)                                                                       
      Mediastinum, Fibrosarcoma, Metastatic, Spleen                 1 (7%)                                                          
   Nose                                               (50)                      (50)                                                
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (2)          (2)                                                 
      Adenoma                                          2 (67%)      2 (100%)     2 (100%)                                           
      Carcinoma                                        1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Urinary Bladder                                    (50)         (2)          (50)                                                
      Papilloma                                                                  1 (2%)                                             
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05006-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 10:23:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Lymphoma Malignant Histiocytic                                             2 (4%)                                             
      Lymphoma Malignant Lymphocytic                                2 (4%)                                                          
      Lymphoma Malignant Mixed                         1 (2%)                    3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05006-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 10:23:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            36          26          40                                                   
     Total Primary Neoplasms                           50          31          62                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 21          13          28                                                   
     Total Benign Neoplasms                            27          13          35                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              20          17          25                                                   
     Total Malignant Neoplasms                         23          18          27                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           1           3                                                   
     Total Metastatic Neoplasm                          8           5           3                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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