National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3124

TDMS Study 05006-06 Pathology Tables

NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97
Route: GAVAGE                                                                                                     Time: 10:54:38




       Facility:  Southern Research Institute

       Chemical CAS #:  100-52-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 6| 7| 7| 4| 5| 7| 7| 7| 0| 5| 5| 6| 7|             
                             DAY ON TEST   | 4| 9| 2| 2| 2| 6| 0| 2| 2| 2| 4| 2| 3| 2| 2| 7| 2| 2| 2| 2| 0| 0| 6| 0| 3|             
                                           | 1| 7| 9| 9| 9| 7| 2| 9| 9| 9| 5| 4| 7| 9| 9| 8| 0| 9| 9| 9| 9| 4| 8| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    VEHICLE                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +|             
      Inflammation, Chronic                |                                  2                                       |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Hemorrhage, Multifocal               |             2                                                            |             
      Necrosis, Multifocal                 |                                                                   3      |             
      Vacuolization Cytoplasmic, Diffuse   |                   2                                                      |             
      Centrilobular, Necrosis              |                3                                                         |             
      Sinusoid, Infiltration Cellular,     |                                                                          |             
           Polymorphonuclear               | 3  3           3                                3                        |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +        +           +        +  +           +                 +      |             
      Abscess                              |                                                                          |             
      Inflammation, Acute, Suppurative     | 2  2                                            2                        |             
      Fat, Necrosis, Focal                 |                         3                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |       2  2        2                                                      |             
      Hyperplasia, Multifocal              |                                                                          |             
      Inflammation, Acute, Focal,          |                                                                          |             
          Suppurative                      |          2                                2                              |             
      Ulcer                                |       2           2                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Dysplasia                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 6| 7| 7| 4| 5| 7| 7| 7| 0| 5| 5| 6| 7|             
                             DAY ON TEST   | 4| 9| 2| 2| 2| 6| 0| 2| 2| 2| 4| 2| 3| 2| 2| 7| 2| 2| 2| 2| 0| 0| 6| 0| 3|             
                                           | 1| 7| 9| 9| 9| 7| 2| 9| 9| 9| 5| 4| 7| 9| 9| 8| 0| 9| 9| 9| 9| 4| 8| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    VEHICLE                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal                   |                      2                                                   |             
      Spindle Cell, Hyperplasia            |                            2                                             |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                        2                                 |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  M  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                    2                     |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                        2                                2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Abscess                              |    4           4                                                         |             
      Abscess, Multiple                    | 4                                               4                        |             
      Cyst                                 |                   X     X           X                 X        X         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |    2                                               3     3               |             
      Hyperplasia, Cystic                  |    3  4  4  3  4  4  2  3  4  2        4  4  4  1  4  4  4  1  4     3  4|             
      Inflammation, Acute, Suppurative     |    4     2     4                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |       +     +     +                                                      |             
      Polychromasia                        |             X     X                                                      |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                            2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Ectasia                       |                                                                          |             
      Mediastinal, Hyperplasia             |                                  2                                       |             
      Mediastinal, Inflammation, Acute,    |                                                                          |             
           Suppurative                     |    3                                                                     |             
      Renal, Hyperplasia                   | 2                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             1                                                            |             
      Hyperplasia                          | 1                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 6| 7| 7| 4| 5| 7| 7| 7| 0| 5| 5| 6| 7|             
                             DAY ON TEST   | 4| 9| 2| 2| 2| 6| 0| 2| 2| 2| 4| 2| 3| 2| 2| 7| 2| 2| 2| 2| 0| 0| 6| 0| 3|             
                                           | 1| 7| 9| 9| 9| 7| 2| 9| 9| 9| 5| 4| 7| 9| 9| 8| 0| 9| 9| 9| 9| 4| 8| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    VEHICLE                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |                                                                1         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3  3        4  4  4              2              3              3         |             
      Hyperplasia, Lymphoid                |          4                                                               |             
      Necrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                 4                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Duct, Cyst                           |                         X                          X                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Hemorrhage, Multifocal               |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                             4            |             
      Hemorrhage, Multifocal               |                                                                          |             
      Hyperplasia, Focal, Lymphoid         |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Mediastinum, Inflammation, Acute,    |                                                                          |             
           Suppurative                     |    3                                                                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |       2                                                                  |             
      Inflammation, Acute, Suppurative     |       2                                                                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |             3                    2                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 6| 7| 7| 4| 5| 7| 7| 7| 0| 5| 5| 6| 7|             
                             DAY ON TEST   | 4| 9| 2| 2| 2| 6| 0| 2| 2| 2| 4| 2| 3| 2| 2| 7| 2| 2| 2| 2| 0| 0| 6| 0| 3|             
                                           | 1| 7| 9| 9| 9| 7| 2| 9| 9| 9| 5| 4| 7| 9| 9| 8| 0| 9| 9| 9| 9| 4| 8| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    VEHICLE                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Glomerulus, Inflammation, Chronic    |                                                                          |             
      Papilla, Necrosis                    |             3                                                            |             
      Renal Tubule, Dilatation, Multifocal |                                  3                                       |             
      Renal Tubule, Regeneration,          |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 7| 1| 3| 3| 3| 3| 4| 3| 3| 3|            |
                                           | 8| 0| 0| 0| 0| 4| 1| 0| 0| 0| 1| 1| 1| 1| 1| 2| 4| 1| 1| 1| 1| 5| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    VEHICLE                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M|  45        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Focal Cellular Change                |                                                                      X   |      1     |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                3                                                        3|      2  3.0|
      Hemorrhage, Multifocal               |                                                 3                        |      2  2.5|
      Necrosis, Multifocal                 |                                                 4                       2|      3  3.0|
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      1  2.0|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|
      Sinusoid, Infiltration Cellular,     |                                                                          |            |
           Polymorphonuclear               |                   2                                                      |      5  2.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                    +        +  +         |  11        |
      Abscess                              |                                                             4            |      1  4.0|
      Inflammation, Acute, Suppurative     |                                                                2         |      4  2.0|
      Fat, Necrosis, Focal                 |                                                    3                     |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |          2                    2           3              1               |      7  2.0|
      Hyperplasia, Multifocal              |                   2                                                      |      1  2.0|
      Inflammation, Acute, Focal,          |                                                                          |            |
          Suppurative                      |                   2                       2                              |      4  2.0|
      Ulcer                                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                 1                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                 +                        |   1        |
      Dysplasia                            |                                                 2                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 7| 1| 3| 3| 3| 3| 4| 3| 3| 3|            |
                                           | 8| 0| 0| 0| 0| 4| 1| 0| 0| 0| 1| 1| 1| 1| 1| 2| 4| 1| 1| 1| 1| 5| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    VEHICLE                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |    X                                                                    X|      2     |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Spindle Cell, Hyperplasia            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                      2                                                   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  M  +  +  +  +  +  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  47        |
      Pars Distalis, Angiectasis           |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                         X                                                |      1     |
      Pars Distalis, Hyperplasia, Focal    |       2                                                                  |      3  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia, Focal           |                                                                         2|      1  2.0|
      Follicular Cell, Hyperplasia, Focal  |                                                                      2   |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  47        |
      Abscess                              |                4                                               3         |      4  3.8|
      Abscess, Multiple                    |                   4                                         4            |      4  4.0|
      Cyst                                 |       X     X        X                                            X  X   |     10     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           |          2     2                                         3               |      6  2.5|
      Hyperplasia, Cystic                  | 4  4  4  4  4  3  2  4  4  2  2  4  4  4  3  2  4  4  3  3  2     3  4  4|     45  3.4|
      Inflammation, Acute, Suppurative     |                2                                2              2         |      6  2.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                 +                        |   4        |
      Polychromasia                        |                                                 X                        |      3     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myelofibrosis                        |                                        2                                 |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 7| 1| 3| 3| 3| 3| 4| 3| 3| 3|            |
                                           | 8| 0| 0| 0| 0| 4| 1| 0| 0| 0| 1| 1| 1| 1| 1| 2| 4| 1| 1| 1| 1| 5| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    VEHICLE                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Iliac, Ectasia                       |                2                                                         |      1  2.0|
      Mediastinal, Hyperplasia             |                                                                          |      1  2.0|
      Mediastinal, Inflammation, Acute,    |                                                                          |            |
           Suppurative                     |                                                                          |      1  3.0|
      Renal, Hyperplasia                   |                2  2                                         3            |      4  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                                                          |      1  1.0|
      Hyperplasia                          |                   2                             3           2            |      4  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +|  47        |
      Angiectasis                          |                                                 3                        |      1  3.0|
      Hyperplasia                          |                2                                                         |      2  1.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                3  3                             4           3  4         |     13  3.3|
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Necrosis, Focal                      |          4                                                               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Atrophy                              |                   4                                                      |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
      Duct, Cyst                           |                               X                                      X   |      4     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                               2                                          |      1  2.0|
      Hemorrhage, Multifocal               |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  4.0|
      Hemorrhage, Multifocal               | 3                                                                        |      1  3.0|
      Hyperplasia, Focal, Lymphoid         |                                                    2                     |      1  2.0|
      Pigmentation, Hemosiderin            |                      2                                                   |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 7| 1| 3| 3| 3| 3| 4| 3| 3| 3|            |
                                           | 8| 0| 0| 0| 0| 4| 1| 0| 0| 0| 1| 1| 1| 1| 1| 2| 4| 1| 1| 1| 1| 5| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    VEHICLE                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                      2  2|      2  2.0|
      Mediastinum, Inflammation, Acute,    |                                                                          |            |
           Suppurative                     |                   3                                         3            |      3  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Acute, Suppurative     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                      +                                +                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydronephrosis                       |                                                                          |      2  2.5|
      Glomerulus, Inflammation, Chronic    |                3  2                                                      |      2  2.5|
      Papilla, Necrosis                    |                                                                          |      1  3.0|
      Renal Tubule, Dilatation, Multifocal |                3  2                                                      |      3  2.7|
      Renal Tubule, Regeneration,          |                                                                          |            |
          Multifocal                       |                2  2                                                      |      2  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 9| 6| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    600.                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                               3              2                           |             
      Necrosis, Multifocal                 | 2                                                                        |             
      Sinusoid, Infiltration Cellular,     |                                                                          |             
           Polymorphonuclear               |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +                 +            |             
      Abscess                              |                                                                          |             
      Inflammation, Acute, Suppurative     |                                                                          |             
      Fat, Necrosis, Focal                 |                                           3                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal                   |          2  2           1  3           2                 2  2     2      |             
      Hyperplasia, Multifocal              | 2              2  2              2                 2  2                  |             
      Inflammation, Acute, Focal,          |                                                                          |             
          Suppurative                      |                            2                                             |             
      Inflammation, Acute, Multifocal,     |                                                                          |             
           Suppurative                     |                                                    2                     |             
      Ulcer                                |                                  3                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty, Focal           |                4                                                         |             
      Hypertrophy, Focal                   |                                                    2                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 9| 6| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    600.                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Bilateral, Infiltration Cellular,    |                                                                          |             
           Polymorphonuclear               |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 3                       2                                      2         |             
      Pars Distalis, Hyperplasia, Focal    |             2  2                                                         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |          X  X                 X                                          |             
      Follicle, Degeneration, Cystic       |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Abscess                              |                               4                                          |             
      Abscess, Multiple                    |                                              4                           |             
      Cyst                                 |          X                             X                 X               |             
      Inflammation, Chronic                |                            4                                             |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |          3                                                           3   |             
      Hyperplasia, Cystic                  | 2  3  2  2  2  3  4  3     3  3  3  3  2  4  3  4  4  3     4  4  4  3  4|             
      Inflammation, Acute, Suppurative     |                      1                       2                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                2                                                         |             
      Myeloid Cell, Hyperplasia            |                                              4                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchial, Inflammation, Acute,      |                                                                          |             
          Suppurative                      |                                                                          |             
      Deep Cervical, Hyperplasia           |                                                                          |             
      Iliac, Hyperplasia                   |                                                                          |             
      Mediastinal, Inflammation, Acute,    |                                                                          |             
           Suppurative                     |                                                                          |             
      Renal, Hyperplasia                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 9| 6| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    600.                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                   3                                                      |             
      Hematopoietic Cell Proliferation     |                               3              4                           |             
      Hemorrhage, Focal                    |                   3                                                      |             
      Hyperplasia, Lymphoid                |                                                          2               |             
      Necrosis, Focal                      |                   2                                                      |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Cyst                           | X                       X                                                |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Mediastinum, Inflammation, Acute,    |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Fungus                               |                                                                          |             
      Inflammation, Acute, Suppurative     |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Subacute                        |                                                       2                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Focal, Osseous           |                      2                                                   |             
      Capsule, Inflammation, Acute,        |                                                                          |             
          Suppurative                      |                                                                          |             
      Glomerulus, Inflammation, Chronic    |                                              3                           |             
      Renal Tubule, Atrophy, Multifocal    |                                                                          |             
      Renal Tubule, Degeneration,          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 9| 6| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    600.                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
          Multifocal                       |    2        2                                                            |             
      Renal Tubule, Dilatation, Multifocal |                                              3                           |             
      Renal Tubule, Nuclear Alteration,    |                                                                          |             
           Multifocal                      |    2        2                                                            |             
      Renal Tubule, Regeneration,          |                                                                          |             
          Multifocal                       |    2        2                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 3| 4| 7| 7| 7|            |
                             DAY ON TEST   | 5| 8| 3| 3| 3| 3| 2| 1| 3| 3| 0| 0| 3| 3| 3| 1| 0| 3| 3| 3| 4| 3| 1| 3| 3|            |
                                           | 6| 8| 1| 1| 1| 5| 3| 1| 1| 1| 0| 4| 1| 1| 1| 8| 2| 1| 1| 1| 4| 7| 8| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    600.                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                3              3                                          |      4  2.8|
      Necrosis, Multifocal                 |                                                                   2      |      2  2.0|
      Sinusoid, Infiltration Cellular,     |                                                                          |            |
           Polymorphonuclear               |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                     +           +           +  +         |   6        |
      Abscess                              |                                     3                                    |      1  3.0|
      Inflammation, Acute, Suppurative     |                                                             2  3         |      2  2.5|
      Fat, Necrosis, Focal                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |          X                                                               |      1     |
      Hyperplasia, Focal                   |          2           2                                   2  2        2   |     13  2.0|
      Hyperplasia, Multifocal              |             2                          2  2        2  2                  |     11  2.0|
      Inflammation, Acute, Focal,          |                                                                          |            |
          Suppurative                      |                      2                                2  2               |      4  2.0|
      Inflammation, Acute, Multifocal,     |                                                                          |            |
           Suppurative                     |                                           2        2                     |      3  2.0|
      Ulcer                                |                                        2                    3            |      3  2.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 3| 4| 7| 7| 7|            |
                             DAY ON TEST   | 5| 8| 3| 3| 3| 3| 2| 1| 3| 3| 0| 0| 3| 3| 3| 1| 0| 3| 3| 3| 4| 3| 1| 3| 3|            |
                                           | 6| 8| 1| 1| 1| 5| 3| 1| 1| 1| 0| 4| 1| 1| 1| 8| 2| 1| 1| 1| 4| 7| 8| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    600.                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Fatty, Focal           |                                                                          |      1  4.0|
      Hypertrophy, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Bilateral, Infiltration Cellular,    |                                                                          |            |
           Polymorphonuclear               |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                                                                X         |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Angiectasis           |                                                                   2      |      4  2.3|
      Pars Distalis, Hyperplasia, Focal    |    2                 2                                                   |      4  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicle, Cyst                       |                                                                          |      3     |
      Follicle, Degeneration, Cystic       |    2  2                                      2                           |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  44        |
      Abscess                              |                                                                          |      1  4.0|
      Abscess, Multiple                    | 4              4              4     4                          4         |      6  4.0|
      Cyst                                 |    X        X           X  X                 X                       X   |      9     |
      Inflammation, Chronic                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           |                                  4                                      3|      4  3.3|
      Hyperplasia, Cystic                  |    2  4  4  4        3  4  4        4  4  4        4  4  4  3        4  4|     39  3.4|
      Inflammation, Acute, Suppurative     | 4              3              3                                3         |      6  2.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                      +                          +                        |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myelofibrosis                        |                                           1                              |      2  1.5|
      Myeloid Cell, Hyperplasia            |    3                                                                     |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bronchial, Inflammation, Acute,      |                                                                          |            |
          Suppurative                      |                                     2                                    |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 3| 4| 7| 7| 7|            |
                             DAY ON TEST   | 5| 8| 3| 3| 3| 3| 2| 1| 3| 3| 0| 0| 3| 3| 3| 1| 0| 3| 3| 3| 4| 3| 1| 3| 3|            |
                                           | 6| 8| 1| 1| 1| 5| 3| 1| 1| 1| 0| 4| 1| 1| 1| 8| 2| 1| 1| 1| 4| 7| 8| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    600.                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Deep Cervical, Hyperplasia           |                               4                                          |      1  4.0|
      Iliac, Hyperplasia                   |                               4                                          |      1  4.0|
      Mediastinal, Inflammation, Acute,    |                                                                          |            |
           Suppurative                     |                                     2                                    |      1  2.0|
      Renal, Hyperplasia                   |                4              4                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +|  45        |
      Angiectasis                          |                                     2                                    |      1  2.0|
      Hyperplasia                          |                1                                                         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosis, Focal                      |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |    4           4              3     3                          3         |      7  3.4|
      Hemorrhage, Focal                    |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                           3              3               |      3  2.7|
      Necrosis, Focal                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Duct, Cyst                           |                                                                   X      |      3     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                                                          3               |      1  3.0|
      Mediastinum, Inflammation, Acute,    |                                                                          |            |
           Suppurative                     |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                         3           2                                    |      2  2.5|
      Fungus                               |                         2                                                |      1  2.0|
      Inflammation, Acute, Suppurative     |                         3                                                |      1  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 3| 4| 7| 7| 7|            |
                             DAY ON TEST   | 5| 8| 3| 3| 3| 3| 2| 1| 3| 3| 0| 0| 3| 3| 3| 1| 0| 3| 3| 3| 4| 3| 1| 3| 3|            |
                                           | 6| 8| 1| 1| 1| 5| 3| 1| 1| 1| 0| 4| 1| 1| 1| 8| 2| 1| 1| 1| 4| 7| 8| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    600.                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Subacute                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                         +|   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                 +                        |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Metaplasia, Focal, Osseous           |                                                                          |      1  2.0|
      Capsule, Inflammation, Acute,        |                                                                          |            |
          Suppurative                      |                               2                                          |      1  2.0|
      Glomerulus, Inflammation, Chronic    |                                                                          |      1  3.0|
      Renal Tubule, Atrophy, Multifocal    |                            2                                             |      1  2.0|
      Renal Tubule, Degeneration,          |                                                                          |            |
          Multifocal                       |                                                                          |      2  2.0|
      Renal Tubule, Dilatation, Multifocal |                                                                          |      1  3.0|
      Renal Tubule, Nuclear Alteration,    |                                                                          |            |
           Multifocal                      |                                                                          |      2  2.0|
      Renal Tubule, Regeneration,          |                                                                          |            |
          Multifocal                       |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 1| 7| 7| 7| 7| 3| 7| 7| 7| 5| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 1| 1| 2| 2| 7| 1| 2| 2| 2| 0| 0| 1| 2| 2| 9| 2| 2| 2| 5| 3| 3| 3| 3| 3|             
                                           | 4| 2| 7| 9| 9| 3| 2| 9| 9| 9| 5| 2| 1| 9| 9| 9| 9| 9| 9| 7| 5| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    300.                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                           +                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                           +                              |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +              +     +                       +                        |             
      Vacuolization Cytoplasmic, Diffuse   |    2                                                                     |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +  +                                                                  |             
      Fat, Necrosis, Focal                 |                                                                          |             
      Fat, Necrosis, Multifocal            |    3                                                                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                               +                                          |             
      Hemorrhage                           |                               2                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                2                             1  2  2  2        2     2   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Multifocal              | 2           2                                                            |             
      Inflammation, Acute, Focal,          |                                                                          |             
          Suppurative                      | 2           2                             1                              |             
      Inflammation, Acute, Multifocal,     |                                                                          |             
           Suppurative                     |                                                                          |             
      Inflammation, Focal, Subacute        |                2                                                         |             
      Mineralization                       |                2                                                         |             
      Ulcer                                |                                              2                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                                                 +                        |             
      Pars Distalis, Hyperplasia, Focal    |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |          +  +                                            +  +           +|             
      Abscess                              |                                                          4               |             
      Abscess, Multiple                    |                                                             4            |             
      Cyst                                 |          X  X                                                           X|             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +        +     +     +  +  +  +  +  +  +           +     +   |             
      Hydrometra                           |                                           3                          2   |             
      Hyperplasia, Cystic                  |    3  2  4  4        4           4  4  4  3  3  4  4           4     4   |             
      Inflammation, Acute, Suppurative     |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 1| 7| 7| 7| 7| 3| 7| 7| 7| 5| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 1| 1| 2| 2| 7| 1| 2| 2| 2| 0| 0| 1| 2| 2| 9| 2| 2| 2| 5| 3| 3| 3| 3| 3|             
                                           | 4| 2| 7| 9| 9| 3| 2| 9| 9| 9| 5| 2| 1| 9| 9| 9| 9| 9| 9| 7| 5| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    300.                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                  +  +  +                                 |             
      Leukocytosis                         |                                        X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +           +                                         +        +   |             
      Iliac, Hyperplasia                   |                                                                          |             
      Iliac, Inflammation, Acute,          |                                                                          |             
          Suppurative                      |                                                                          |             
      Mediastinal, Hyperplasia             |                                                                          |             
      Renal, Hyperplasia                   |                                                             3            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +           +                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +           +                                                  +   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +           +           +     +  +  +     +           +        +   |             
      Atrophy                              |                               2                                          |             
      Hematopoietic Cell Proliferation     |                                     4  4  3                 4            |             
      Hyperplasia, Focal, Lymphoid         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                     +                                    |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Hemorrhage      |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +                                                                        |             
      Cranium, Hypertrophy, Focal          | 2                                                                        |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +                                                                        |             
      Compression                          | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +                                      +  +                        |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 6| 7| 7| 6| 6| 7| 7| 7| 4| 5| 6| 6| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7|            |
                             DAY ON TEST   | 8| 4| 1| 3| 3| 6| 7| 3| 3| 3| 3| 9| 2| 6| 3| 7| 3| 3| 3| 3| 5| 4| 3| 3| 3|            |
                                           | 6| 5| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 1| 1| 3| 1| 1| 1| 1| 6| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    300.                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Liver                                   |          +                          +                          +         |   8        |
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                       +                             +      |   5        |
      Fat, Necrosis, Focal                 |             2                       3                             2      |      3  2.3|
      Fat, Necrosis, Multifocal            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                      2     2              2  2                           |     11  1.9|
      Hyperplasia, Lymphoid                |                                                       3                  |      1  3.0|
      Hyperplasia, Multifocal              |                2                                      2                  |      4  2.0|
      Inflammation, Acute, Focal,          |                                                                          |            |
          Suppurative                      |                      2                    2  2           2               |      7  1.9|
      Inflammation, Acute, Multifocal,     |                                                                          |            |
           Suppurative                     |                                                       2                  |      1  2.0|
      Inflammation, Focal, Subacute        |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +                                                              +   |   3        |
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +        +           +              +           +     +         |  14        |
      Abscess                              | 4     4           4           4              4                           |      6  4.0|
      Abscess, Multiple                    |    4                                                                     |      2  4.0|
      Cyst                                 |          X                                               X     X         |      6     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 6| 7| 7| 6| 6| 7| 7| 7| 4| 5| 6| 6| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7|            |
                             DAY ON TEST   | 8| 4| 1| 3| 3| 6| 7| 3| 3| 3| 3| 9| 2| 6| 3| 7| 3| 3| 3| 3| 5| 4| 3| 3| 3|            |
                                           | 6| 5| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 1| 1| 3| 1| 1| 1| 1| 6| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    300.                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  |       +  +           +  +  +     +     +  +        +  +  +     +     +  +|  29        |
      Hydrometra                           |                                  2                    3        4        3|      6  2.8|
      Hyperplasia, Cystic                  |       3  4           4  3  4           4  3        4  4  3     4     4  4|     27  3.7|
      Inflammation, Acute, Suppurative     |                                                          4               |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                 +                        |   4        |
      Leukocytosis                         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +        +              +  +                       +               |  10        |
      Iliac, Hyperplasia                   |                               3  3                       2               |      3  2.7|
      Iliac, Inflammation, Acute,          |                                                                          |            |
          Suppurative                      |                                                          2               |      1  2.0|
      Mediastinal, Hyperplasia             |                               3                                          |      1  3.0|
      Renal, Hyperplasia                   |       2                                                                  |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                +                                                         |   5        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +     +  +     +        +              +           +           +   |  18        |
      Atrophy                              |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |       4                       4              4           4               |      8  3.9|
      Hyperplasia, Focal, Lymphoid         |                                                                      3   |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                 +                        |   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Subcutaneous Tissue, Hemorrhage      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |   1        |
      Cranium, Hypertrophy, Focal          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |   1        |
      Compression                          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |   4        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 6| 7| 7| 6| 6| 7| 7| 7| 4| 5| 6| 6| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7|            |
                             DAY ON TEST   | 8| 4| 1| 3| 3| 6| 7| 3| 3| 3| 3| 9| 2| 6| 3| 7| 3| 3| 3| 3| 5| 4| 3| 3| 3|            |
                                           | 6| 5| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 1| 1| 3| 1| 1| 1| 1| 6| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    300.                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                             +                                          |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 0| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 5| 3| 3| 3| 3| 4| 1| 3| 3| 3| 7| 3| 3| 3| 3| 0| 7| 3| 3| 3|             
                                           | 8| 7| 6| 6| 6| 1| 6| 6| 6| 6| 8| 3| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Muscularis, Degeneration             |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                  4                                       |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            X                                             |             
      Focal Cellular Change                |                         X                                                |             
      Necrosis, Focal                      |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +        +                                                   |             
      Fat, Necrosis, Focal                 |             2        3                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                  2        2           2  2               |             
      Inflammation, Acute, Focal,          |                                                                          |             
          Suppurative                      |                                           2              2               |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |    +                 +  +  +              +           +  +        +  +   |             
      Dysplasia                            |    4                 2  3  3              2           2  4        2  4   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |             2                             2                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 0| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 5| 3| 3| 3| 3| 4| 1| 3| 3| 3| 7| 3| 3| 3| 3| 0| 7| 3| 3| 3|             
                                           | 8| 7| 6| 6| 6| 1| 6| 6| 6| 6| 8| 3| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  M  M  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                                          |             
      Follicle, Degeneration, Cystic       |                      2  2                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                           +                              |             
      Duct, Cyst                           |                                           X                              |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                               +                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Angiectasis                          |                                        3  2              2               |             
      Hyperplasia                          |                      2                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     |    3                 3        3                                3         |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +|             
      Cyst                                 |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema, Focal                         |                                                                          |             
      Fibrosis, Focal                      |    2                                                                     |             
      Foreign Body, Focal                  |                                                                          |             
      Inflammation, Focal, Subacute        |                      3                                                   |             
      Mineralization, Focal                |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 0| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 5| 3| 3| 3| 3| 4| 1| 3| 3| 3| 7| 3| 3| 3| 3| 0| 7| 3| 3| 3|             
                                           | 8| 7| 6| 6| 6| 1| 6| 6| 6| 6| 8| 3| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                             3            |             
      Infiltration Cellular, Histiocyte    |                                     4                                    |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Fat, Mediastinum, Necrosis, Focal    |                                                                3         |             
      Mediastinum, Foreign Body            |                                                             2            |             
      Mediastinum, Hemorrhage              |                                                             2            |             
      Mediastinum, Inflammation, Acute,    |                                                                          |             
           Suppurative                     |                                                             2            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                   3  2  2                          2                    2|             
      Fungus                               |                   2                                                      |             
      Inflammation, Acute, Suppurative     |                   2  2  2                          2     2              2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute, Suppurative              | 2                                                                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                    2                     |             
      Metaplasia, Focal, Osseous           |                                                                          |             
      Glomerulus, Amyloid Deposition       |    4                                                                     |             
      Renal Tubule, Degeneration,          |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 7| 0| 7| 6| 7| 7| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 1| 3| 3| 3| 1| 3| 0| 3| 3| 5| 5| 6| 3| 3| 7| 3| 3| 3| 3| 0| 3| 3| 3| 3|            |
                                           | 0| 5| 6| 6| 6| 1| 7| 9| 7| 7| 6| 9| 1| 7| 7| 6| 4| 7| 7| 7| 2| 7| 7| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                | 2                                                                        |      1  2.0|
      Muscularis, Degeneration             |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  M  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Diverticulum                         |                                                                          |      1  4.0|
      Inflammation, Chronic, Focal         |                      2                                                   |      1  2.0|
      Epithelium, Hyperplasia, Focal       |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                          X               |      2     |
      Focal Cellular Change                |                                                                          |      1     |
      Necrosis, Focal                      |                                     4                                    |      1  4.0|
      Necrosis, Multifocal                 |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +  +              +                           |   5        |
      Fat, Necrosis, Focal                 |                            3                 3                           |      4  2.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Focal                       |          3        4                                                      |      2  3.5|
      Cyst                                 |          X        X                                                      |      2     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                     2           2              2         |      7  2.0|
      Inflammation, Acute, Focal,          |                                                                          |            |
          Suppurative                      |                                                                2         |      3  2.0|
      Ulcer                                |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |       +  +  +     +        +  +        +  +        +  +                 +|  20        |
      Dysplasia                            |       4  2  4     2        4  3        4  3        4  2                 4|     20  3.1|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 7| 0| 7| 6| 7| 7| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 1| 3| 3| 3| 1| 3| 0| 3| 3| 5| 5| 6| 3| 3| 7| 3| 3| 3| 3| 0| 3| 3| 3| 3|            |
                                           | 0| 5| 6| 6| 6| 1| 7| 9| 7| 7| 6| 9| 1| 7| 7| 6| 4| 7| 7| 7| 2| 7| 7| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  M  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicle, Cyst                       |                                                    X                     |      1     |
      Follicle, Degeneration, Cystic       |                               2                                          |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                 +                        |   2        |
      Duct, Cyst                           |                                                 X                        |      2     |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                        +           +                     |   2        |
      Dilatation                           |                                        3           3                     |      2  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  46        |
      Angiectasis                          |             3                       3           2                        |      6  2.5|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                     3                                    |      1  3.0|
      Hematopoietic Cell Proliferation     |    3                 3        3              3                 3         |      9  3.0|
      Hyperplasia, Lymphoid                |                                                          3               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  M  M  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +|  41        |
      Cyst                                 |                                           X                              |      2     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 7| 0| 7| 6| 7| 7| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 1| 3| 3| 3| 1| 3| 0| 3| 3| 5| 5| 6| 3| 3| 7| 3| 3| 3| 3| 0| 3| 3| 3| 3|            |
                                           | 0| 5| 6| 6| 6| 1| 7| 9| 7| 7| 6| 9| 1| 7| 7| 6| 4| 7| 7| 7| 2| 7| 7| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema, Focal                         |                                                             2            |      1  2.0|
      Fibrosis, Focal                      |                         2                                                |      2  2.0|
      Foreign Body, Focal                  |                                                             2            |      1  2.0|
      Inflammation, Focal, Subacute        |                                                                          |      1  3.0|
      Mineralization, Focal                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                               +                 +                        |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                3                                                         |      2  3.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  4.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                           2                              |      1  2.0|
      Fat, Mediastinum, Necrosis, Focal    |                                                                          |      1  3.0|
      Mediastinum, Foreign Body            | 2              2                                            2            |      4  2.0|
      Mediastinum, Hemorrhage              |                                                                          |      1  2.0|
      Mediastinum, Inflammation, Acute,    |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |    2                    2  2                 2           2               |     10  2.1|
      Fungus                               |                                                                          |      1  2.0|
      Inflammation, Acute, Suppurative     |    2                    2  2                 2           2               |     11  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute, Suppurative              |                      2                          2                        |      3  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                              +                           |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +                                         +                       +   |   3        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 7| 0| 7| 6| 7| 7| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7| 0| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 1| 3| 3| 3| 1| 3| 0| 3| 3| 5| 5| 6| 3| 3| 7| 3| 3| 3| 3| 0| 3| 3| 3| 3|            |
                                           | 0| 5| 6| 6| 6| 1| 7| 9| 7| 7| 6| 9| 1| 7| 7| 6| 4| 7| 7| 7| 2| 7| 7| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
      Metaplasia, Focal, Osseous           |                                                                      2   |      1  2.0|
      Glomerulus, Amyloid Deposition       |                                                                          |      1  4.0|
      Renal Tubule, Degeneration,          |                                                                          |            |
          Multifocal                       |                                     2        2                 3         |      3  2.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 0| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 4| 7| 7| 7|             
                             DAY ON TEST   | 6| 8| 3| 3| 3| 1| 5| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 7| 1| 3| 3|             
                                           | 8| 2| 6| 6| 6| 4| 9| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 1| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    400.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Epithelium, Hyperplasia, Focal       |          2                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                        2                                 |             
      Focal Cellular Change                |                                                          X               |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Hemorrhage, Focal                    |                                                                3         |             
      Necrosis, Focal                      |                                                                3         |             
      Necrosis, Multifocal                 | 3                                                                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                +         |             
      Hemorrhage, Focal                    |                                                                4         |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                              2                           |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                              X                           |             
      Hyperplasia, Focal                   | 2     2  2              2        2                    2  2        2      |             
      Hyperplasia, Multifocal              |                                        2                                 |             
      Infiltration Cellular, Mast Cell     |                                                                          |             
      Inflammation, Acute, Focal,          |                                                                          |             
          Suppurative                      | 2     2                                1                 2               |             
      Ulcer                                |                                                       2           2      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |       +  +  +        +  +  +           +           +     +        +      |             
      Dysplasia                            |       2  4  4        4  4  4           3           3     4        3      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Subacute       |                                                             3            |             
      Valve, Inflammation, Subacute        |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 0| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 4| 7| 7| 7|             
                             DAY ON TEST   | 6| 8| 3| 3| 3| 1| 5| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 7| 1| 3| 3|             
                                           | 8| 2| 6| 6| 6| 4| 9| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 1| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    400.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                4         |             
      Hyperplasia, Focal                   |                         2  2                       2                     |             
      Necrosis                             |                                                                4         |             
      Spindle Cell, Hyperplasia            |                                  3                                       |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                4         |             
      Hyperplasia, Focal                   |                                                                         2|             
      Necrosis                             |                                                                4         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |             X                                                            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                          2               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +           +                                   +  +              +      |             
      Inflammation, Acute, Suppurative     | 3           4                                   3                        |             
      Duct, Cyst                           |                                                    X              X      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |             +        +                                                   |             
      Dilatation                           |             4        2                                                   |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                              2        2  2           2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                      +   |             
      Polychromasia                        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             3        2  2              2                 2               |             
      Hemorrhage                           |                                                                   4      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 0| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 4| 7| 7| 7|             
                             DAY ON TEST   | 6| 8| 3| 3| 3| 1| 5| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 7| 1| 3| 3|             
                                           | 8| 2| 6| 6| 6| 4| 9| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 1| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    400.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Developmental Malformation           |                                                                          |             
      Hematopoietic Cell Proliferation     | 4                 3                                            3     4   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  M  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  +  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  +  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                 3                        |             
      Alopecia                             |                                                                          |             
      Developmental Malformation           |                                                                          |             
      Fibrosis, Focal                      |                                                 2  2                     |             
      Fibrosis, Multifocal                 |                                              2                           |             
      Inflammation, Focal, Subacute        |                                                                          |             
      Mineralization, Focal                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                             +            |             
      Artery, Inflammation, Subacute       |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |    2                                                                     |             
      Infiltration Cellular, Histiocyte    |                                                       2                  |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Mediastinum, Foreign Body            |                3                                                         |             
      Mediastinum, Inflammation, Acute,    |                                                                          |             
           Suppurative                     |                3                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |       2  2                                2              2               |             
      Inflammation, Acute, Suppurative     |       2  2                                2              2               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                             +            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 0| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 4| 7| 7| 7|             
                             DAY ON TEST   | 6| 8| 3| 3| 3| 1| 5| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 7| 1| 3| 3|             
                                           | 8| 2| 6| 6| 6| 4| 9| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 1| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    400.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Metaplasia, Focal, Osseous           |       2              2                                            2      |             
      Mineralization, Multifocal           |             2                                                            |             
      Cortex, Cyst                         |                                                                          |             
      Papilla, Necrosis                    |                                                                          |             
      Renal Tubule, Degeneration,          |                                                                          |             
          Multifocal                       |                                                    2           2         |             
      Renal Tubule, Dilatation, Multifocal |                                                    2                     |             
      Renal Tubule, Necrosis, Multifocal   |                                                                          |             
      Renal Tubule, Regeneration,          |                                                                          |             
          Multifocal                       |                                                    2                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 5| 7| 7| 5| 5| 6| 7| 7| 7| 5| 7| 7| 7| 4| 5| 6| 7| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 9| 3| 7| 3| 3| 2| 7| 5| 3| 3| 3| 3| 3| 3| 3| 7| 6| 9| 3| 3| 7| 1| 3| 3| 3|            |
                                           | 3| 6| 5| 6| 6| 9| 1| 4| 6| 6| 7| 5| 7| 7| 7| 7| 9| 3| 7| 7| 6| 7| 7| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    400.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                                                          |      1  2.0|
      Focal Cellular Change                |                                                                          |      1     |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                3                                                         |      1  3.0|
      Hemorrhage, Focal                    |                                                                          |      1  3.0|
      Necrosis, Focal                      | 2                                                                        |      2  2.5|
      Necrosis, Multifocal                 |                                                    2                     |      2  2.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +                                             |   2        |
      Hemorrhage, Focal                    |                                                                          |      1  4.0|
      Fat, Necrosis, Focal                 |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy, Focal                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |       2              1                    2                              |      4  1.7|
      Hyperplasia, Focal                   |                      2        2        2        2        3        2  2   |     15  2.1|
      Hyperplasia, Multifocal              |                                                                          |      1  2.0|
      Infiltration Cellular, Mast Cell     |                               2                                          |      1  2.0|
      Inflammation, Acute, Focal,          |                                                                          |            |
          Suppurative                      |                                        2                 2           2   |      7  1.9|
      Ulcer                                |                                                                   2  2   |      4  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |    +        +              +                                            +|  14        |
      Dysplasia                            |    4        4              3                                            3|     14  3.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 5| 7| 7| 5| 5| 6| 7| 7| 7| 5| 7| 7| 7| 4| 5| 6| 7| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 9| 3| 7| 3| 3| 2| 7| 5| 3| 3| 3| 3| 3| 3| 3| 7| 6| 9| 3| 3| 7| 1| 3| 3| 3|            |
                                           | 3| 6| 5| 6| 6| 9| 1| 4| 6| 6| 7| 5| 7| 7| 7| 7| 9| 3| 7| 7| 6| 7| 7| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    400.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Artery, Inflammation, Subacute       |                                                                          |      1  3.0|
      Valve, Inflammation, Subacute        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Focal                   |                                                                          |      3  2.0|
      Necrosis                             |                                                                          |      1  4.0|
      Spindle Cell, Hyperplasia            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Focal                   |                                                                   2      |      2  2.0|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +                    +                                                   |   7        |
      Inflammation, Acute, Suppurative     |                      3                                                   |      4  3.3|
      Duct, Cyst                           | X                    X                                                   |      4     |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +                                                           +        +|   5        |
      Dilatation                           |    3                                                                     |      3  3.0|
      Inflammation, Chronic                |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                            +                                             |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 5| 7| 7| 5| 5| 6| 7| 7| 7| 5| 7| 7| 7| 4| 5| 6| 7| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 9| 3| 7| 3| 3| 2| 7| 5| 3| 3| 3| 3| 3| 3| 3| 7| 6| 9| 3| 3| 7| 1| 3| 3| 3|            |
                                           | 3| 6| 5| 6| 6| 9| 1| 4| 6| 6| 7| 5| 7| 7| 7| 7| 9| 3| 7| 7| 6| 7| 7| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    400.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Polychromasia                        |                            X                                             |      2     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myeloid Cell, Hyperplasia            |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |             2                                                            |      6  2.2|
      Hemorrhage                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                              3                           |      2  3.0|
      Developmental Malformation           |                                     2                                    |      1  2.0|
      Hematopoietic Cell Proliferation     |                3  3        4     4                 4                 3   |     10  3.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  45        |
      Hyperplasia                          |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  +  M  M  M  M  +  +  +  M  M  M  +  M  +  M  M  +  +  M  M  M  +|  12        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                                                                          |      1  3.0|
      Alopecia                             | X                                                                        |      1     |
      Developmental Malformation           |                         2                                         2      |      2  2.0|
      Fibrosis, Focal                      |       2                    2                             2  2        2   |      7  2.0|
      Fibrosis, Multifocal                 |                                                                          |      1  2.0|
      Inflammation, Focal, Subacute        | 2                       2                                                |      2  2.0|
      Mineralization, Focal                |                      3                                                   |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +                                                                        |   2        |
      Artery, Inflammation, Subacute       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                      3              2                                    |      3  2.3|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 5| 7| 7| 5| 5| 6| 7| 7| 7| 5| 7| 7| 7| 4| 5| 6| 7| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 9| 3| 7| 3| 3| 2| 7| 5| 3| 3| 3| 3| 3| 3| 3| 7| 6| 9| 3| 3| 7| 1| 3| 3| 3|            |
                                           | 3| 6| 5| 6| 6| 9| 1| 4| 6| 6| 7| 5| 7| 7| 7| 7| 9| 3| 7| 7| 6| 7| 7| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    400.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Focal                           |             2                       3              2           2         |      4  2.3|
      Mediastinum, Foreign Body            |                                                                          |      1  3.0|
      Mediastinum, Inflammation, Acute,    |                                                                          |            |
           Suppurative                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |             2     2  2     2     2     2  2  3                       2   |     13  2.1|
      Inflammation, Acute, Suppurative     |    2        2        2     2     3  2  2  2  3                       2   |     14  2.1|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                      +                                                   |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                               +                                +         |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Focal                      |          2                                                               |      1  2.0|
      Metaplasia, Focal, Osseous           |                                                                          |      3  2.0|
      Mineralization, Multifocal           |                                                                          |      1  2.0|
      Cortex, Cyst                         |                         X                             X  X               |      3     |
      Papilla, Necrosis                    |                3                                                         |      1  3.0|
      Renal Tubule, Degeneration,          |                                                                          |            |
          Multifocal                       | 3              2                                                         |      4  2.3|
      Renal Tubule, Dilatation, Multifocal |                3                                                         |      2  2.5|
      Renal Tubule, Necrosis, Multifocal   | 2                                                                        |      1  2.0|
      Renal Tubule, Regeneration,          |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 0| 6| 7| 7| 7| 7| 5| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 9| 1| 3| 3| 3| 7| 3| 3| 3| 1| 4| 3| 3| 3| 2| 3| 3| 3| 3|             
                                           | 6| 6| 6| 6| 6| 2| 7| 7| 6| 6| 7| 1| 6| 6| 6| 3| 1| 7| 7| 7| 7| 7| 7| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +                                                         |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                   +                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                   M                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                   +                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                   +                                                      |             
                                            __________________________________________________________________________|             
   Liver                                   | +        +        +     +     +  +  +           +     +  +  +        +   |             
      Hepatodiaphragmatic Nodule           |                                                          2               |             
      Hyperplasia, Focal, Lymphoid         |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                   3                                                      |             
      Vacuolization Cytoplasmic, Focal     |                                                 2     4                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                               +      |             
      Fat, Necrosis, Focal                 |                                                                   4      |             
      Fat, Necrosis, Multifocal            |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                   +                                                      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                      X   |             
      Hyperplasia, Focal                   |                                  1              2     3                  |             
      Hyperplasia, Multifocal              |                                                          2               |             
      Inflammation, Acute, Focal,          |                                                                          |             
          Suppurative                      |          1                       1              2     2  2               |             
      Inflammation, Chronic, Focal         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Focal,          |                                                                          |             
          Suppurative                      |                2                                                         |             
                                            __________________________________________________________________________|             
   Tongue                                  |                      +                                                   |             
      Ectopic Tissue                       |                      2                                                   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Dysplasia                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 0| 6| 7| 7| 7| 7| 5| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 9| 1| 3| 3| 3| 7| 3| 3| 3| 1| 4| 3| 3| 3| 2| 3| 3| 3| 3|             
                                           | 6| 6| 6| 6| 6| 2| 7| 7| 6| 6| 7| 1| 6| 6| 6| 3| 1| 7| 7| 7| 7| 7| 7| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute, Suppurative     |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +                                      +                       M   |             
      Inflammation, Acute, Suppurative     |       2                                                                  |             
      Duct, Cyst                           |                                              X                           |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                        +  +                              |             
      Dilatation                           |                                        2  3                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                               +                                          |             
      Leukocytosis                         |                               2                                          |             
      Polychromasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +                                +        +            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                   +                                +        +            |             
      Angiectasis                          |                                                    2                     |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |                   +  +                    +              +  +            |             
      Atrophy                              |                                                                          |             
      Congestion                           |                                           3                              |             
      Hematopoietic Cell Proliferation     |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +     +  +  +  +        +  +                    +      |             
      Cyst Epithelial Inclusion            |                            X                                             |             
      Fibrosis, Focal                      |                                                                   2      |             
      Inflammation, Acute, Focal,          |                                                                          |             
          Suppurative                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
      Hemorrhage                           |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +        +  +  +                 +                 +           +   |             
      Foreign Body                         |                2                                                         |             
      Hemorrhage, Focal                    |                                                                          |             
      Hemorrhage, Multifocal               |                2                                                         |             
      Infiltration Cellular, Histiocyte    |       1                                                                  |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                        1                                 |             
                                            __________________________________________________________________________|             
   Trachea                                 |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 0| 6| 7| 7| 7| 7| 5| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 9| 1| 3| 3| 3| 7| 3| 3| 3| 1| 4| 3| 3| 3| 2| 3| 3| 3| 3|             
                                           | 6| 6| 6| 6| 6| 2| 7| 7| 6| 6| 7| 1| 6| 6| 6| 3| 1| 7| 7| 7| 7| 7| 7| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Perforation                          |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Fibrosis                     |                                                                          |             
      Cornea, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                               +  +                                       |             
      Renal Tubule, Dilatation, Multifocal |                                  3                                       |             
      Renal Tubule, Necrosis, Multifocal   |                                  3                                       |             
      Renal Tubule, Regeneration,          |                                                                          |             
          Multifocal                       |                                  3                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +                                                                        |             
      Hemorrhage, Focal                    |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 5| 7| 7| 7| 2| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 5| 7| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 2| 3| 3| 3| 1| 7| 3| 3| 3| 9| 3| 3| 3| 3| 2| 9| 0| 0| 3| 7| 3| 3| 3| 3|            |
                                           | 3| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 4| 0| 8| 7| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    200.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                                                        |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                +         |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                +         |   2        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +           +        +     +        +                              |  18        |
      Hepatodiaphragmatic Nodule           |                                                                          |      1  2.0|
      Hyperplasia, Focal, Lymphoid         |                            2                                             |      1  2.0|
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic, Focal     |                                           3                              |      3  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +  +                          +                                    |   5        |
      Fat, Necrosis, Focal                 |       4  3                                                               |      3  3.7|
      Fat, Necrosis, Multifocal            |                                     4                                    |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                     +                                    |   2        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                            1                                             |      2  1.0|
      Hyperplasia, Focal                   |                            1        1                       2            |      6  1.7|
      Hyperplasia, Multifocal              |                               2                                          |      2  2.0|
      Inflammation, Acute, Focal,          |                                                                          |            |
          Suppurative                      |                                                                          |      5  1.6|
      Inflammation, Chronic, Focal         |                      1                                                   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute, Focal,          |                                                                          |            |
          Suppurative                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Ectopic Tissue                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                            +                                             |   1        |
      Dysplasia                            |                            4                                             |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 5| 7| 7| 7| 2| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 5| 7| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 2| 3| 3| 3| 1| 7| 3| 3| 3| 9| 3| 3| 3| 3| 2| 9| 0| 0| 3| 7| 3| 3| 3| 3|            |
                                           | 3| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 4| 0| 8| 7| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    200.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                        +                                 |   1        |
      Dilatation                           |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                    +                     |   1        |
      Hemorrhage                           |                                                    3                     |      1  3.0|
      Inflammation, Acute, Suppurative     |                                                    4                     |      1  4.0|
      Necrosis                             |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                   +                                   +        +         |   5        |
      Inflammation, Acute, Suppurative     |                                                       3                  |      2  2.5|
      Duct, Cyst                           |                   X                                   X        X         |      4     |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                         +           +                             +      |   5        |
      Dilatation                           |                         2           2                             3      |      5  2.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                +         |   2        |
      Leukocytosis                         |                                                                          |      1  2.0|
      Polychromasia                        |                                                                X         |      1     |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                      +                                +                  |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                      +                                +                  |   5        |
      Angiectasis                          |                      2                                                   |      2  2.0|
      Hyperplasia                          |                                                       4                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                               +                       +                  |   7        |
      Atrophy                              |                               4                                          |      1  4.0|
      Congestion                           |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                       4                  |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |                +  +  +  +  +     +           +     +  +  +  +  +     +   |  26        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Fibrosis, Focal                      |                                                          2               |      2  2.0|
      Inflammation, Acute, Focal,          |                                                                          |            |
          Suppurative                      |                                                    3                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05006-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 10:54:38  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 5| 7| 7| 7| 2| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 5| 7| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 2| 3| 3| 3| 1| 7| 3| 3| 3| 9| 3| 3| 3| 3| 2| 9| 0| 0| 3| 7| 3| 3| 3| 3|            |
                                           | 3| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 4| 0| 8| 7| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    200.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |             +  +  +     +     +              +                    +      |  14        |
      Foreign Body                         |                                                                          |      1  2.0|
      Hemorrhage, Focal                    |                2                                                         |      1  2.0|
      Hemorrhage, Multifocal               |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                                   2      |      2  1.5|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |             1     3                                                      |      3  1.7|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |   1        |
      Perforation                          |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                          +                                 |   2        |
      Cornea, Fibrosis                     |             4                                                            |      1  4.0|
      Cornea, Inflammation, Chronic        |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +                          +                                 |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |   2        |
      Renal Tubule, Dilatation, Multifocal |                                                                          |      1  3.0|
      Renal Tubule, Necrosis, Multifocal   |                                                                          |      1  3.0|
      Renal Tubule, Regeneration,          |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                    +                     |   2        |
      Hemorrhage, Focal                    |                                                    3                     |      1  3.0|
      Inflammation, Subacute               |                                                    4                     |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.