National Toxicology Program

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TDMS Study 05006-06 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Southern Research Inst                                    DATE: 09/03/94   
EXP: 05006                      BENZALDEHYDE                   TIME: 10:32:53   
TEST: 06              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 56133    
CONT: NO1CP9565101                                             CAS: 100-52-7    
PATHOLOGIST: H. GILES                        S.EUSTIS                           
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
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REMOVAL DATE RANGE:                                                             


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NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Southern Research Inst                                    DATE: 09/03/94  
EXP: 05006                      BENZALDEHYDE                   TIME: 10:32:53  
TEST: 06              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 56133   
CONT: NO1CP9565101                                             CAS: 100-52-7   
PATHOLOGIST: H. GILES                        S.EUSTIS                          

                                   BENZALDEHYDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 736 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = VEHICLE CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 14     CENSORED DEATHS 4    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      448   451   556   576   576   609   638   659   661   675                 |
 |      697   713   715   734                                                     |
 |  CENSORED DEATHS                                                               |
 |      2     5     10    11                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 200.    MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 15     CENSORED DEATHS 2    TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      219   313   498   504   527   541   571   577   577   627                 |
 |      697   697   700   717   727                                               |
 |  CENSORED DEATHS                                                               |
 |      2     3                                                                   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 400.    MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 17     CENSORED DEATHS 2    TERMINAL 31        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      293   345   471   477   529   535   568   569   571   575                 |
 |      576   640   654   659   693   717   718                                   |
 |  CENSORED DEATHS                                                               |
 |      14    682                                                                 |
 |                                                                                |
 ==================================================================================

                                   BENZALDEHYDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 736 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   736 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |   100.0 100.0 100.0 100.0 100.0  95.7  95.7  89.1  80.4  69.6      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |200.       |   100.0 100.0  97.9  95.8  95.8  95.8  87.5  81.3  79.2  68.8      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 |400.       |   100.0 100.0 100.0  95.9  95.9  91.8  87.8  77.6  71.4  65.1      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                VEHICLE          200.             400.          |
 |                                CONTROL          MG/KG            MG/KG         |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       69.6%            68.8%            65.1%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.592          P=1.000          P=0.654       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       622.0            566.1            564.1         |
 |NATURAL DEATHS (C)      |       (24.5)           (37.8)           (28.9)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       645.8            655.7            662.0         |
 |(STANDARD ERROR)        |       (28.6)           (24.6)           (20.0)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                   BENZALDEHYDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = VEHICLE CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 2    TERMINAL 30        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      445   478   504   504   520   521   531   541   568   603                 |
 |      624   637   645   667   672   697   702   714                             |
 |  CENSORED DEATHS                                                               |
 |      9     638                                                                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 300.    MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 21     CENSORED DEATHS 2    TERMINAL 27        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      399   431   473   486   535   545   557   591   612   614                 |
 |      624   624   641   661   661   671   673   702   711   712                 |
 |      717                                                                       |
 |  CENSORED DEATHS                                                               |
 |      105   456                                                                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 600.    MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 15     CENSORED DEATHS 0    TERMINAL 35        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      344   437   456   486   500   526   535   604   618   623                 |
 |      684   688   702   711   718                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                   BENZALDEHYDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |   100.0 100.0 100.0 100.0 100.0  95.9  83.7  79.6  73.4  62.9      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |300.       |   100.0 100.0 100.0 100.0  98.0  93.8  87.6  83.4  68.8  56.3      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 |600.       |   100.0 100.0 100.0  98.0  98.0  94.0  86.0  84.0  80.0  70.0      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                VEHICLE          300.             600.          |
 |                                CONTROL          MG/KG            MG/KG         |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       62.9%            56.3%            70.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.521N         P=0.695          P=0.589N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       587.4            601.9            575.5         |
 |NATURAL DEATHS (C)      |       (20.0)           (20.5)           (30.0)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       661.8            657.7            682.9         |
 |(STANDARD ERROR)        |       (17.9)           (17.2)           (13.3)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                            BENZALDEHYDE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE CONTROL  = 1
                                                        200.    MG/KG    = 2
                                                        400.    MG/KG    = 3

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                  2          3                       1
      |
      |                                    2          3   2    3              1 1
      |                                                   2    3                1  3   2        1
   95 +
      |                                                                            33           1  1
P     |
E     |                                                                             3  2    2
R  90 +                                                                                     232
C     |                                                                                            1    1
E     |                                                                                      32   2     1    1
N     |
T  85 +                                                                                           22         1   1
      |
S     |
U     |                                                                                           32       2
R  80 +                                                                                                          1 1
V     |                                                                                                    2       1  1
I     |                                                                                            3         3
V     |                                                                                                               1 1
A  75 +                                                                                                      3 3
L     |                                                                                                        3 3      11
      |                                                                                                               2  2
      |                                                                                                          3   3   12 1
   70 +                                                                                                                     11
      |                                                                                                              3   32  2
      |
      |
   65 +                                                                                                                  3   3
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 8 obs hidden.

                                                            BENZALDEHYDE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE CONTROL  = 1
                                                        300.    MG/KG    = 2
                                                        600.    MG/KG    = 3

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                      3       2      1
      |
      |                                                        3       2    231     1
      |                                                                     23   3 21  1
   95 +
      |                                                                          3 2 2
      |                                                                              3 3
      |                                                                              2 1   1 2
   90 +                                                                                3    322
      |
P     |                                                                                    1132 2
E     |                                                                                     131         3
R  85 +                                                                                         2     2
C     |                                                                                       1   1   2 323
E     |
N     |                                                                                           1     1
T  80 +                                                                                                 1 31        3
      |                                                                                                  2 2
S     |                                                                                                    11       33
U     |                                                                                                              3 3
R  75 +                                                                                                    2121
V     |                                                                                                       1   1    33
I     |                                                                                                      2   2      33
V     |
A  70 +                                                                                                                  3  3
L     |                                                                                                          21   1
      |                                                                                                               11
      |                                                                                                           22
   65 +                                                                                                            2   11
      |
      |                                                                                                                21   1
      |
   60 +
      |                                                                                                                 22
      |
      |                                                                                                                  2  2
   55 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 7 obs hidden.

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