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TDMS Study 05006-05 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                            BENZALDEHYDE


NTP Experiment-Test: 05006-05                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/03/94
Route: GAVAGE                                                                                                     Time: 08:49:07




       Facility:  Southern Research Institute

       Chemical CAS #:  000100527

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          13           16           12                                                  
    Dead                                               4            1            9                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           33           29                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (49)         (1)          (50)                                                
      Parasite Metazoan                                1 (2%)                    5 (10%)                                            
   Intestine Large, Colon                             (49)         (1)          (50)                                                
      Parasite Metazoan                                3 (6%)                    1 (2%)                                             
   Intestine Large, Rectum                            (48)         (1)          (50)                                                
      Parasite Metazoan                                4 (8%)                    5 (10%)                                            
   Intestine Small, Duodenum                          (49)         (1)          (46)                                                
      Erosion                                                                    1 (2%)                                             
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis                                      1 (2%)       4 (8%)                                                          
      Basophilic Focus                                41 (82%)     43 (86%)     36 (72%)                                            
      Clear Cell Focus                                 2 (4%)       4 (8%)       3 (6%)                                             
      Developmental Malformation                       4 (8%)      10 (20%)      7 (14%)                                            
      Focal Cellular Change                            3 (6%)                    2 (4%)                                             
      Granuloma                                       13 (26%)     15 (30%)     21 (42%)                                            
      Hematopoietic Cell Proliferation                 2 (4%)       2 (4%)       1 (2%)                                             
      Inflammation, Chronic                            4 (8%)       9 (18%)      3 (6%)                                             
      Mixed Cell Focus                                 1 (2%)       1 (2%)                                                          
      Bile Duct, Cyst Multilocular                     1 (2%)                                                                       
      Bile Duct, Hyperplasia                          25 (50%)     19 (38%)     12 (24%)                                            
      Centrilobular, Atrophy                           1 (2%)       5 (10%)      4 (8%)                                             
      Hepatocyte, Hyperplasia, Nodular                 2 (4%)       5 (10%)      7 (14%)                                            
      Hepatocyte, Vacuolization Cytoplasmic            3 (6%)       4 (8%)       1 (2%)                                             
      Kupffer Cell, Hyperplasia                                     1 (2%)                                                          
      Kupffer Cell, Pigmentation                       2 (4%)                    3 (6%)                                             
      Lobules, Necrosis                                3 (6%)       6 (12%)      4 (8%)                                             
   Mesentery                                          (9)          (5)          (6)                                                 
      Accessory Spleen                                                           1 (17%)                                            
      Infiltration Cellular, Histiocyte                1 (11%)                                                                      
      Artery, Hypertrophy                                                        2 (33%)                                            
      Artery, Inflammation, Chronic Active                                       2 (33%)                                            
      Fat, Inflammation, Chronic                                    1 (20%)                                                         
      Fat, Inflammation, Granulomatous                 2 (22%)      2 (40%)      1 (17%)                                            
      Fat, Inflammation, Suppurative                                             1 (17%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fat, Mineralization                                           3 (60%)      1 (17%)                                            
      Fat, Necrosis                                    6 (67%)      5 (100%)     3 (50%)                                            
   Pancreas                                           (48)         (2)          (50)                                                
      Atrophy                                          4 (8%)       1 (50%)      2 (4%)                                             
      Ectopic Tissue                                   1 (2%)                                                                       
      Hyperplasia, Nodular                             5 (10%)                   5 (10%)                                            
      Inflammation, Chronic                                                      2 (4%)                                             
   Salivary Glands                                    (50)                      (50)                                                
      Ectasia                                                                    1 (2%)                                             
      Inflammation, Chronic                            2 (4%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Edema                                            2 (4%)                    1 (2%)                                             
      Fibrosis                                                                   1 (2%)                                             
      Inflammation, Chronic                            2 (4%)                    2 (4%)                                             
      Inflammation, Suppurative                        1 (2%)                                                                       
      Mineralization                                   1 (2%)                                                                       
      Ulcer                                            1 (2%)       1 (2%)       1 (2%)                                             
      Mucosa, Dysplasia                                             1 (2%)                                                          
      Mucosa, Hyperplasia                              5 (10%)      2 (4%)       3 (6%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)                                                
      Cyst                                                          1 (2%)                                                          
      Edema                                            1 (2%)                                                                       
      Erosion                                                       1 (2%)       3 (6%)                                             
      Inflammation, Granulomatous                      1 (2%)                    1 (2%)                                             
      Mineralization                                   5 (10%)      8 (16%)      1 (2%)                                             
      Ulcer                                            1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Cardiomyopathy                                  20 (40%)     15 (30%)     19 (38%)                                            
      Thrombosis                                                                 1 (2%)                                             
      Epicardium, Inflammation, Chronic Active                                   1 (2%)                                             
      Myocardium, Inflammation, Chronic                7 (14%)      8 (16%)      1 (2%)                                             
      Myocardium, Mineralization                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Accessory Adrenal Cortical Nodule                8 (16%)      8 (16%)      3 (6%)                                             
      Angiectasis                                      5 (10%)      7 (14%)      8 (16%)                                            
      Basophilic Focus                                              1 (2%)       1 (2%)                                             
      Clear Cell Focus                                 9 (18%)     10 (20%)      8 (16%)                                            
      Cyst Multilocular                                             1 (2%)                                                          
      Hemorrhage                                                                 2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                      6 (12%)      5 (10%)      5 (10%)                                            
      Necrosis                                                                   3 (6%)                                             
      Vacuolization Cytoplasmic, Diffuse               1 (2%)       3 (6%)                                                          
   Adrenal Gland, Medulla                             (49)         (49)         (47)                                                
      Cyst                                             1 (2%)                                                                       
      Fibrosis                                         1 (2%)                                                                       
      Hyperplasia                                      1 (2%)       4 (8%)       1 (2%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
   Islets, Pancreatic                                 (48)         (2)          (50)                                                
      Hyperplasia                                                                1 (2%)                                             
   Pituitary Gland                                    (49)         (49)         (49)                                                
      Pars Distalis, Angiectasis                       3 (6%)       4 (8%)       8 (16%)                                            
      Pars Distalis, Cyst                             14 (29%)     15 (31%)      9 (18%)                                            
      Pars Distalis, Hyperplasia                       4 (8%)       4 (8%)      10 (20%)                                            
      Pars Distalis, Pigmentation                      1 (2%)       1 (2%)       2 (4%)                                             
      Pars Intermedia, Angiectasis                                  1 (2%)                                                          
      Pars Intermedia, Cyst                                         2 (4%)       1 (2%)                                             
      Pars Intermedia, Hyperplasia                                               1 (2%)                                             
      Pars Nervosa, Hyperplasia                        1 (2%)                    1 (2%)                                             
   Thyroid Gland                                      (50)         (4)          (50)                                                
      Ultimobranchial Cyst                             1 (2%)                    1 (2%)                                             
      C-Cell, Hyperplasia                              7 (14%)      1 (25%)      7 (14%)                                            
      Follicle, Cyst                                   1 (2%)       1 (25%)                                                         
      Follicular Cell, Hyperplasia                     1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (45)         (50)         (48)                                                
      Ectasia                                          6 (13%)      2 (4%)       7 (15%)                                            
      Hyperplasia                                      3 (7%)       1 (2%)       7 (15%)                                            
      Inflammation, Chronic                            6 (13%)      6 (12%)      4 (8%)                                             
      Inflammation, Suppurative                        6 (13%)      2 (4%)      12 (25%)                                            
      Metaplasia, Squamous                                                       1 (2%)                                             
   Ovary                                              (49)         (3)          (50)                                                
      Atrophy                                          1 (2%)                                                                       
      Cyst                                             4 (8%)       2 (67%)      7 (14%)                                            
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
   Uterus                                             (49)         (12)         (50)                                                
      Angiectasis                                                                1 (2%)                                             
      Cyst                                                          3 (25%)      1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Hemorrhage                                                    1 (8%)       2 (4%)                                             
      Hydrometra                                       2 (4%)       1 (8%)       1 (2%)                                             
      Hyperplasia, Cystic                              4 (8%)       1 (8%)       4 (8%)                                             
      Inflammation, Suppurative                        1 (2%)       1 (8%)       1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
      Endometrium, Dysplasia                                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (2)          (1)          (2)                                                 
      Anemia                                           1 (50%)      1 (100%)     2 (100%)                                           
      Leukocytosis                                     1 (50%)                                                                      
   Bone Marrow                                        (50)         (5)          (50)                                                
      Hyperplasia, Reticulum Cell                      3 (6%)       1 (20%)      5 (10%)                                            
      Myelofibrosis                                    1 (2%)                                                                       
      Proliferation                                    3 (6%)                                                                       
   Lymph Node                                         (50)         (1)          (50)                                                
      Mediastinal, Hyperplasia, Plasma Cell                                      1 (2%)                                             
   Lymph Node, Mandibular                             (46)                      (47)                                                
      Hyperplasia, Plasma Cell                         1 (2%)                    2 (4%)                                             
      Lymphatic, Dilatation                            2 (4%)                    1 (2%)                                             
   Lymph Node, Mesenteric                             (48)         (1)          (50)                                                
      Depletion Cellular                               1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                    2 (4%)                                             
      Pigmentation                                                               1 (2%)                                             
   Spleen                                             (50)         (50)         (50)                                                
      Congestion                                       1 (2%)       1 (2%)                                                          
      Fibrosis                                         1 (2%)       1 (2%)                                                          
      Hematopoietic Cell Proliferation                 6 (12%)     10 (20%)      4 (8%)                                             
      Hyperplasia, Re Cell                             1 (2%)                    1 (2%)                                             
      Necrosis                                                      2 (4%)                                                          
      Pigmentation, Hemosiderin                        3 (6%)       7 (14%)      7 (14%)                                            
      Lymphoid Follicle, Atrophy                                                 1 (2%)                                             
      Red Pulp, Atrophy                                1 (2%)                    1 (2%)                                             
   Thymus                                             (47)                      (46)                                                
      Cyst                                             1 (2%)                    1 (2%)                                             
      Fibrosis                                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)                                                
      Hyperplasia, Cystic                             43 (86%)     45 (90%)     32 (64%)                                            
      Hyperplasia, Lobular                             8 (16%)     10 (20%)      3 (6%)                                             
   Skin                                               (50)         (29)         (50)                                                
      Acanthosis                                       1 (2%)       1 (3%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Fibrosis                                         1 (2%)                                                                       
      Inflammation, Chronic                                         1 (3%)                                                          
      Inflammation, Suppurative                        1 (2%)                                                                       
      Ulcer                                            1 (2%)                                                                       
      Nipple, Hypertrophy                                           1 (3%)                                                          
      Subcutaneous Tissue, Inflammation,                                                                                            
          Granulomatous                                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Cranium, Hyperostosis                            6 (12%)      7 (14%)      1 (2%)                                             
      Femur, Hyperostosis                              7 (14%)      7 (14%)      1 (2%)                                             
      Sternum, Hyperostosis                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Compression                                      7 (14%)     16 (32%)      3 (6%)                                             
      Hemorrhage                                                                 2 (4%)                                             
      Hydrocephalus                                    2 (4%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic                                                      2 (4%)                                             
      Vacuolization Cytoplasmic                                                  1 (2%)                                             
   Peripheral Nerve                                   (47)         (50)         (49)                                                
      Inflammation, Chronic                            1 (2%)       1 (2%)       1 (2%)                                             
   Spinal Cord                                        (50)         (50)         (50)                                                
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Axon, White Matter, Degeneration                 1 (2%)                                                                       
      Gray Matter, Degeneration                        2 (4%)       1 (2%)       1 (2%)                                             
      Parenchyma, White Matter, Degeneration,                                                                                       
          Multifocal                                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Congestion                                       2 (4%)       2 (4%)       4 (8%)                                             
      Fibrosis                                         1 (2%)                                                                       
      Infiltration Cellular, Histiocyte               26 (52%)     14 (28%)     14 (28%)                                            
      Inflammation, Chronic                            1 (2%)       1 (2%)                                                          
      Inflammation, Suppurative                                                  1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 2 (4%)       2 (4%)       2 (4%)                                             
      Mediastinum, Inflammation, Chronic Active        1 (2%)                                                                       
      Subpleura, Inflammation, Chronic Active          1 (2%)                                                                       
   Nose                                               (50)                      (50)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Exudate                                          4 (8%)                    6 (12%)                                            
      Fungus                                           1 (2%)                                                                       
      Inflammation, Chronic                            2 (4%)                                                                       
      Mucosa, Hyperplasia                                                        1 (2%)                                             
      Mucosa, Metaplasia, Squamous                     2 (4%)                                                                       
   Trachea                                            (50)                      (50)                                                
      Exudate                                                                    1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Mucosa, Metaplasia, Squamous                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (49)                                                
      Cataract                                        21 (42%)     19 (38%)     25 (51%)                                            
      Hemorrhage                                                    1 (2%)                                                          
      Cornea, Inflammation, Chronic                                              1 (2%)                                             
      Cornea, Neovascularization                                                 1 (2%)                                             
      Retina, Atrophy                                 43 (86%)     42 (84%)     40 (82%)                                            
      Sclera, Mineralization                           5 (10%)     11 (22%)      6 (12%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Angiectasis                                                   1 (2%)                                                          
      Cyst                                                          2 (4%)                                                          
      Fibrosis                                                                   1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Hydronephrosis                                                2 (4%)                                                          
      Infarct                                          1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic                            3 (6%)       7 (14%)      1 (2%)                                             
      Inflammation, Suppurative                                     1 (2%)       3 (6%)                                             
      Mineralization                                  43 (86%)     45 (90%)     41 (82%)                                            
      Nephropathy                                     33 (66%)     41 (82%)     34 (68%)                                            
      Papilla, Necrosis                                             1 (2%)                                                          
      Renal Tubule, Cytoplasmic Alteration             1 (2%)                                                                       
      Renal Tubule, Degeneration                       2 (4%)       3 (6%)                                                          
      Renal Tubule, Dilatation                                                   2 (4%)                                             
      Renal Tubule, Necrosis                           1 (2%)                    1 (2%)                                             
      Renal Tubule, Pigmentation                                                 2 (4%)                                             
      Transitional Epithelium, Hyperplasia                          2 (4%)       2 (4%)                                             
   Urethra                                                                      (1)                                                 
      Calculus Micro Observation Only                                            1 (100%)                                           
      Inflammation, Suppurative                                                  1 (100%)                                           
      Mucosa, Hyperplasia                                                        1 (100%)                                           
   Urinary Bladder                                    (49)                      (49)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Edema                                            1 (2%)                                                                       
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Suppurative                                                  1 (2%)                                             
      Mineralization                                                             1 (2%)                                             
      Ulcer                                                                      1 (2%)                                             
      Mucosa, Hyperplasia                                                        3 (6%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          10           12           17                                                  
    Dead                                               3            9           12                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           29           21                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (49)         (48)         (47)                                                
      Edema                                                         2 (4%)       1 (2%)                                             
      Inflammation, Suppurative                                     1 (2%)       1 (2%)                                             
      Parasite Metazoan                                5 (10%)      4 (8%)       3 (6%)                                             
   Intestine Large, Colon                             (50)         (49)         (48)                                                
      Inflammation, Granulomatous                                                1 (2%)                                             
      Parasite Metazoan                                5 (10%)      3 (6%)       3 (6%)                                             
   Intestine Large, Rectum                            (49)         (49)         (45)                                                
      Mineralization                                                1 (2%)                                                          
      Parasite Metazoan                                9 (18%)      7 (14%)      4 (9%)                                             
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis                                                   4 (8%)       4 (8%)                                             
      Basophilic Focus                                37 (74%)     31 (62%)     20 (40%)                                            
      Clear Cell Focus                                15 (30%)     11 (22%)      5 (10%)                                            
      Congestion                                                    2 (4%)       1 (2%)                                             
      Degeneration, Cystic                                          2 (4%)       1 (2%)                                             
      Developmental Malformation                       7 (14%)      6 (12%)      6 (12%)                                            
      Eosinophilic Focus                                            1 (2%)                                                          
      Focal Cellular Change                            4 (8%)                    4 (8%)                                             
      Granuloma                                       23 (46%)     12 (24%)      1 (2%)                                             
      Hematopoietic Cell Proliferation                              6 (12%)      3 (6%)                                             
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Inflammation, Chronic                            2 (4%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic Active                     3 (6%)                    1 (2%)                                             
      Bile Duct, Cyst Multilocular                     1 (2%)       1 (2%)                                                          
      Bile Duct, Hyperplasia                          47 (94%)     45 (90%)     37 (74%)                                            
      Centrilobular, Atrophy                           2 (4%)       1 (2%)       4 (8%)                                             
      Centrilobular, Necrosis                                       4 (8%)       3 (6%)                                             
      Hepatocyte, Hyperplasia, Nodular                 3 (6%)       3 (6%)       5 (10%)                                            
      Hepatocyte, Vacuolization Cytoplasmic           15 (30%)     14 (28%)      2 (4%)                                             
      Kupffer Cell, Hyperplasia                                     4 (8%)       1 (2%)                                             
      Kupffer Cell, Pigmentation                                    2 (4%)                                                          
      Lobules, Necrosis                                1 (2%)       3 (6%)       2 (4%)                                             
   Mesentery                                          (16)         (22)         (19)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Accessory Spleen                                                           1 (5%)                                             
      Artery, Hypertrophy                              2 (13%)                   3 (16%)                                            
      Artery, Inflammation, Chronic Active             3 (19%)      1 (5%)       6 (32%)                                            
      Artery, Mineralization                                        1 (5%)                                                          
      Fat, Inflammation, Granulomatous                 3 (19%)     10 (45%)      3 (16%)                                            
      Fat, Mineralization                              8 (50%)     13 (59%)      9 (47%)                                            
      Fat, Necrosis                                   12 (75%)     15 (68%)     12 (63%)                                            
      Fat, Pigmentation                                             1 (5%)                                                          
   Pancreas                                           (49)         (49)         (48)                                                
      Atrophy                                         10 (20%)      9 (18%)      5 (10%)                                            
      Basophilic Focus                                                           2 (4%)                                             
      Hyperplasia, Nodular                             6 (12%)      6 (12%)     12 (25%)                                            
      Inflammation, Chronic                            4 (8%)                    1 (2%)                                             
      Inflammation, Granulomatous                      1 (2%)                                                                       
   Salivary Glands                                    (50)         (50)         (49)                                                
      Atrophy                                                       2 (4%)                                                          
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Inflammation, Suppurative                                                  1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Edema                                            1 (2%)       3 (6%)                                                          
      Erosion                                                                    1 (2%)                                             
      Inflammation, Chronic                            1 (2%)       1 (2%)       1 (2%)                                             
      Mineralization                                                2 (4%)       1 (2%)                                             
      Perforation                                      1 (2%)                                                                       
      Ulcer                                                         3 (6%)       1 (2%)                                             
      Mucosa, Dysplasia                                1 (2%)                                                                       
      Mucosa, Hyperplasia                              2 (4%)       3 (6%)       3 (6%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)                                                
      Edema                                            1 (2%)       1 (2%)                                                          
      Erosion                                          1 (2%)       2 (4%)       3 (6%)                                             
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Inflammation, Chronic                                         2 (4%)                                                          
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
      Mineralization                                   1 (2%)       6 (12%)      3 (6%)                                             
      Ulcer                                            2 (4%)                    2 (4%)                                             
      Mucosa, Dysplasia                                                          1 (2%)                                             
   Tongue                                             (1)                                                                           
      Hyperkeratosis                                   1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (1)          (1)                                                 
      Aorta, Fibrosis                                                            1 (100%)                                           
      Aorta, Hemorrhage                                                          1 (100%)                                           
      Aorta, Inflammation, Chronic                                               1 (100%)                                           
      Aorta, Mineralization                                         1 (100%)                                                        
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
   Heart                                              (50)         (50)         (50)                                                
      Cardiomyopathy                                  37 (74%)     42 (84%)     40 (80%)                                            
      Thrombosis                                       2 (4%)       4 (8%)       1 (2%)                                             
      Epicardium, Fibrosis                                                       1 (2%)                                             
      Epicardium, Inflammation, Chronic                1 (2%)                    1 (2%)                                             
      Myocardium, Inflammation, Chronic                             2 (4%)       5 (10%)                                            
      Myocardium, Mineralization                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Accessory Adrenal Cortical Nodule                4 (8%)      10 (20%)      8 (16%)                                            
      Angiectasis                                      5 (10%)      6 (12%)      1 (2%)                                             
      Basophilic Focus                                 2 (4%)                                                                       
      Clear Cell Focus                                 7 (14%)      6 (12%)      7 (14%)                                            
      Cyst                                                                       1 (2%)                                             
      Fibrosis                                                                   1 (2%)                                             
      Hematopoietic Cell Proliferation                              4 (8%)                                                          
      Hyperplasia                                      2 (4%)       9 (18%)      3 (6%)                                             
      Necrosis                                                                   1 (2%)                                             
      Vacuolization Cytoplasmic, Diffuse                            6 (12%)      4 (8%)                                             
   Adrenal Gland, Medulla                             (49)         (50)         (49)                                                
      Hyperplasia                                      2 (4%)       6 (12%)      3 (6%)                                             
      Infiltration Cellular, Mononuclear Cell                       1 (2%)                                                          
   Islets, Pancreatic                                 (49)         (48)         (48)                                                
      Hyperplasia                                      3 (6%)                                                                       
   Parathyroid Gland                                  (48)         (46)         (46)                                                
      Hyperplasia                                      1 (2%)                                                                       
   Pituitary Gland                                    (49)         (50)         (49)                                                
      Pars Distalis, Angiectasis                       4 (8%)       1 (2%)                                                          
      Pars Distalis, Cyst                              1 (2%)       6 (12%)      2 (4%)                                             
      Pars Distalis, Hyperplasia                       4 (8%)      10 (20%)      8 (16%)                                            
      Pars Intermedia, Angiectasis                                  1 (2%)                                                          
      Pars Intermedia, Cyst                                         2 (4%)       1 (2%)                                             
      Pars Nervosa, Hyperplasia                                                  1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (49)                                                
      Concretion                                                    1 (2%)                                                          
      Mineralization                                                1 (2%)                                                          
      Pigmentation                                    18 (36%)     19 (38%)     10 (20%)                                            
      Ultimobranchial Cyst                                          1 (2%)       1 (2%)                                             
      C-Cell, Hyperplasia                              7 (14%)     15 (30%)      4 (8%)                                             
      Follicle, Cyst                                   2 (4%)       2 (4%)       1 (2%)                                             
      Follicular Cell, Hyperplasia                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)                                                              
      Hemorrhage                                                    1 (100%)                                                        
      Infiltration Cellular, Mononuclear Cell                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (50)         (49)                                                
      Fibrosis                                                      1 (2%)                                                          
      Pigmentation                                                  1 (2%)                                                          
   Preputial Gland                                    (50)         (50)         (50)                                                
      Ectasia                                          1 (2%)       4 (8%)       5 (10%)                                            
      Hyperplasia                                                   1 (2%)       1 (2%)                                             
      Inflammation, Chronic                           35 (70%)     25 (50%)     25 (50%)                                            
      Inflammation, Suppurative                        4 (8%)       9 (18%)      6 (12%)                                            
      Metaplasia, Squamous                                          2 (4%)                                                          
      Mineralization                                                             1 (2%)                                             
      Necrosis                                                      1 (2%)                                                          
   Prostate                                           (50)         (50)         (50)                                                
      Corpora Amylacea                                 2 (4%)       6 (12%)      1 (2%)                                             
      Ectasia                                          1 (2%)                                                                       
      Fibrosis                                         4 (8%)       4 (8%)                                                          
      Inflammation, Chronic                           10 (20%)     21 (42%)      5 (10%)                                            
      Inflammation, Suppurative                       20 (40%)     27 (54%)      6 (12%)                                            
   Testes                                             (50)         (50)         (49)                                                
      Mineralization                                  24 (48%)     23 (46%)     11 (22%)                                            
      Spermatocele                                     1 (2%)                                                                       
      Interstitial Cell, Hyperplasia                   1 (2%)                    2 (4%)                                             
      Seminiferous Tubule, Atrophy                     2 (4%)       7 (14%)      7 (14%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (1)                                                                           
      Anemia                                           1 (100%)                                                                     
      Leukocytosis                                     1 (100%)                                                                     
   Bone Marrow                                        (50)         (50)         (50)                                                
      Angiectasis                                      1 (2%)       1 (2%)       1 (2%)                                             
      Depletion Cellular                                            1 (2%)                                                          
      Hyperplasia, Reticulum Cell                      1 (2%)                    1 (2%)                                             
      Myelofibrosis                                                              1 (2%)                                             
      Proliferation                                                 9 (18%)      3 (6%)                                             
   Lymph Node                                         (50)         (50)         (50)                                                
      Inguinal, Hyperplasia, Lymphoid                  1 (2%)                                                                       
      Mediastinal, Erythrophagocytosis                 2 (4%)       1 (2%)                                                          
      Mediastinal, Hemorrhage                          1 (2%)       2 (4%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Mediastinal, Hyperplasia, Plasma Cell                                      1 (2%)                                             
      Mediastinal, Hyperplasia, Reticulum Cell                      1 (2%)                                                          
      Mediastinal, Infiltration Cellular, Mast Cell                 1 (2%)                                                          
      Mediastinal, Pigmentation                                     3 (6%)                                                          
   Lymph Node, Mandibular                             (49)         (48)         (46)                                                
      Depletion Cellular                                            1 (2%)                                                          
      Erythrophagocytosis                              1 (2%)       1 (2%)                                                          
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Hyperplasia, Plasma Cell                         3 (6%)       2 (4%)       5 (11%)                                            
      Hyperplasia, Reticulum Cell                                   1 (2%)                                                          
      Lymphatic, Dilatation                            5 (10%)      1 (2%)       3 (7%)                                             
   Lymph Node, Mesenteric                             (50)         (49)         (48)                                                
      Depletion Cellular                                            1 (2%)                                                          
      Erythrophagocytosis                                           2 (4%)                                                          
      Hemorrhage                                       1 (2%)       1 (2%)       3 (6%)                                             
      Infiltration Cellular, Mast Cell                              2 (4%)       1 (2%)                                             
      Pigmentation                                    38 (76%)     33 (67%)     26 (54%)                                            
   Spleen                                             (50)         (50)         (50)                                                
      Congestion                                                    1 (2%)                                                          
      Fibrosis                                         2 (4%)       1 (2%)       3 (6%)                                             
      Hematopoietic Cell Proliferation                 6 (12%)     11 (22%)      6 (12%)                                            
      Hyperplasia, Re Cell                             1 (2%)       1 (2%)                                                          
      Necrosis                                                                   1 (2%)                                             
      Pigmentation, Hemosiderin                        1 (2%)       5 (10%)      2 (4%)                                             
      Lymphoid Follicle, Atrophy                                    2 (4%)       2 (4%)                                             
      Red Pulp, Atrophy                                             3 (6%)       4 (8%)                                             
   Thymus                                             (47)         (30)         (49)                                                
      Cyst                                             2 (4%)                                                                       
      Hemorrhage                                                                 1 (2%)                                             
      Epithelial Cell, Hyperplasia                     1 (2%)       2 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (47)         (47)         (44)                                                
      Hyperplasia, Cystic                             16 (34%)     16 (34%)      7 (16%)                                            
      Hyperplasia, Lobular                             2 (4%)       5 (11%)      1 (2%)                                             
      Inflammation, Granulomatous                                   1 (2%)                                                          
   Skin                                               (50)         (49)         (50)                                                
      Acanthosis                                                    1 (2%)                                                          
      Cyst Epithelial Inclusion                        1 (2%)       6 (12%)      2 (4%)                                             
      Cyst Multilocular                                             1 (2%)                                                          
      Fibrosis                                         2 (4%)                                                                       
      Foreign Body                                                  1 (2%)                                                          
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Chronic                                         1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Inflammation, Suppurative                        1 (2%)       1 (2%)       2 (4%)                                             
      Mineralization                                                             2 (4%)                                             
      Ulcer                                                                      2 (4%)                                             
      Hair Follicle, Atrophy                                        1 (2%)                                                          
      Sebaceous Gland, Ectasia                         1 (2%)                                                                       
      Subcutaneous Tissue, Edema                                    1 (2%)                                                          
      Subcutaneous Tissue, Fibrosis                    2 (4%)                                                                       
      Subcutaneous Tissue, Granuloma                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Cranium, Hyperostosis                                         1 (2%)                                                          
   Skeletal Muscle                                    (1)          (4)          (3)                                                 
      Edema                                                         1 (25%)                                                         
      Hemorrhage                                                                 1 (33%)                                            
      Inflammation, Chronic                                                      1 (33%)                                            
      Inflammation, Chronic Active                                  1 (25%)                                                         
      Mineralization                                                             1 (33%)                                            
      Necrosis                                                                   1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Compression                                      2 (4%)       2 (4%)       1 (2%)                                             
      Corpora Amylacea                                                           1 (2%)                                             
      Developmental Malformation                                    1 (2%)                                                          
      Hemorrhage                                                    2 (4%)       2 (4%)                                             
      Hydrocephalus                                    2 (4%)       1 (2%)                                                          
      Inflammation, Chronic                                                      1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
   Peripheral Nerve                                   (49)         (49)         (46)                                                
      Infiltration Cellular, Mast Cell                              1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)       1 (2%)                                                          
      Axon, Hypertrophy                                             2 (4%)                                                          
   Spinal Cord                                        (50)         (50)         (50)                                                
      Gray Matter, Cytoplasmic Alteration                           1 (2%)                                                          
      Gray Matter, Degeneration                        1 (2%)       1 (2%)       1 (2%)                                             
      Gray Matter, Necrosis                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Adenomatosis                                     1 (2%)       1 (2%)       1 (2%)                                             
      Congestion                                       1 (2%)       4 (8%)       8 (16%)                                            
      Foreign Body                                     1 (2%)       1 (2%)                                                          
      Hemorrhage                                       1 (2%)                                                                       
      Infiltration Cellular, Histiocyte               18 (36%)     14 (28%)      9 (18%)                                            
      Inflammation, Chronic                            1 (2%)       1 (2%)       2 (4%)                                             
      Leukocytosis                                                               1 (2%)                                             
      Mineralization                                   1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 2 (4%)       3 (6%)       4 (8%)                                             
      Alveolus, Edema                                  1 (2%)       1 (2%)       3 (6%)                                             
      Artery, Mediastinum, Hypertrophy                 1 (2%)                    1 (2%)                                             
      Artery, Mediastinum, Inflammation, Chronic                                                                                    
          Active                                       1 (2%)                    1 (2%)                                             
      Lymphatic, Dilatation                                         1 (2%)                                                          
      Mediastinum, Edema                                            1 (2%)                                                          
   Nose                                               (50)         (50)         (50)                                                
      Exudate                                         14 (28%)      9 (18%)      8 (16%)                                            
      Foreign Body                                     1 (2%)       3 (6%)       3 (6%)                                             
      Fungus                                          10 (20%)      4 (8%)       2 (4%)                                             
      Inflammation, Chronic                            7 (14%)      3 (6%)       4 (8%)                                             
      Mucosa, Hyperplasia                              3 (6%)       2 (4%)       2 (4%)                                             
      Mucosa, Metaplasia, Squamous                     5 (10%)      5 (10%)      2 (4%)                                             
   Trachea                                            (50)         (50)         (50)                                                
      Inflammation, Chronic                                         2 (4%)                                                          
      Mineralization                                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (45)                                                
      Cataract                                         9 (18%)      3 (6%)      10 (22%)                                            
      Hemorrhage                                                    1 (2%)                                                          
      Cornea, Inflammation, Chronic                                 1 (2%)                                                          
      Cornea, Mineralization                           1 (2%)                                                                       
      Retina, Atrophy                                 31 (62%)     28 (56%)     35 (78%)                                            
      Sclera, Mineralization                          25 (50%)     26 (52%)     20 (44%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Angiectasis                                                   1 (2%)                                                          
      Cyst                                             1 (2%)                                                                       
      Fibrosis                                                      1 (2%)                                                          
      Glomerulosclerosis                                            1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Hydronephrosis                                                1 (2%)       1 (2%)                                             
      Infarct                                                                    3 (6%)                                             
      Inflammation, Chronic                           29 (58%)     30 (60%)     32 (64%)                                            
      Inflammation, Suppurative                        9 (18%)     13 (26%)     13 (26%)                                            
      Mineralization                                   8 (16%)     15 (30%)     10 (20%)                                            
      Nephropathy                                     50 (100%)    49 (98%)     44 (88%)                                            
      Capsule, Fibrosis                                1 (2%)                                                                       
      Renal Tubule, Cytoplasmic Alteration             1 (2%)                                                                       
      Renal Tubule, Degeneration                                    1 (2%)                                                          
      Renal Tubule, Hyperplasia                        1 (2%)                    1 (2%)                                             
      Renal Tubule, Necrosis                                                     2 (4%)                                             
      Renal Tubule, Pigmentation                                    2 (4%)       3 (6%)                                             
      Transitional Epithelium, Hyperplasia             1 (2%)                    5 (10%)                                            
      Venule, Infiltration Cellular, Histiocyte                     1 (2%)                                                          
      Venule, Pigmentation                                          1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
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                             ----------              END OF REPORT             ----------                                           
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