Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/3128

TDMS Study 05006-05 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                            BENZALDEHYDE


NTP Experiment-Test: 05006-05                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/03/94
Route: GAVAGE                                                                                                     Time: 08:49:07




       Facility:  Southern Research Institute

       Chemical CAS #:  000100527

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          13           16           12                                                  
    Dead                                               4            1            9                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           33           29                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (49)         (1)          (50)                                                
      Parasite Metazoan                                1 (2%)                    5 (10%)                                            
   Intestine Large, Colon                             (49)         (1)          (50)                                                
      Parasite Metazoan                                3 (6%)                    1 (2%)                                             
   Intestine Large, Rectum                            (48)         (1)          (50)                                                
      Parasite Metazoan                                4 (8%)                    5 (10%)                                            
   Intestine Small, Duodenum                          (49)         (1)          (46)                                                
      Erosion                                                                    1 (2%)                                             
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis                                      1 (2%)       4 (8%)                                                          
      Basophilic Focus                                41 (82%)     43 (86%)     36 (72%)                                            
      Clear Cell Focus                                 2 (4%)       4 (8%)       3 (6%)                                             
      Developmental Malformation                       4 (8%)      10 (20%)      7 (14%)                                            
      Focal Cellular Change                            3 (6%)                    2 (4%)                                             
      Granuloma                                       13 (26%)     15 (30%)     21 (42%)                                            
      Hematopoietic Cell Proliferation                 2 (4%)       2 (4%)       1 (2%)                                             
      Inflammation, Chronic                            4 (8%)       9 (18%)      3 (6%)                                             
      Mixed Cell Focus                                 1 (2%)       1 (2%)                                                          
      Bile Duct, Cyst Multilocular                     1 (2%)                                                                       
      Bile Duct, Hyperplasia                          25 (50%)     19 (38%)     12 (24%)                                            
      Centrilobular, Atrophy                           1 (2%)       5 (10%)      4 (8%)                                             
      Hepatocyte, Hyperplasia, Nodular                 2 (4%)       5 (10%)      7 (14%)                                            
      Hepatocyte, Vacuolization Cytoplasmic            3 (6%)       4 (8%)       1 (2%)                                             
      Kupffer Cell, Hyperplasia                                     1 (2%)                                                          
      Kupffer Cell, Pigmentation                       2 (4%)                    3 (6%)                                             
      Lobules, Necrosis                                3 (6%)       6 (12%)      4 (8%)                                             
   Mesentery                                          (9)          (5)          (6)                                                 
      Accessory Spleen                                                           1 (17%)                                            
      Infiltration Cellular, Histiocyte                1 (11%)                                                                      
      Artery, Hypertrophy                                                        2 (33%)                                            
      Artery, Inflammation, Chronic Active                                       2 (33%)                                            
      Fat, Inflammation, Chronic                                    1 (20%)                                                         
      Fat, Inflammation, Granulomatous                 2 (22%)      2 (40%)      1 (17%)                                            
      Fat, Inflammation, Suppurative                                             1 (17%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fat, Mineralization                                           3 (60%)      1 (17%)                                            
      Fat, Necrosis                                    6 (67%)      5 (100%)     3 (50%)                                            
   Pancreas                                           (48)         (2)          (50)                                                
      Atrophy                                          4 (8%)       1 (50%)      2 (4%)                                             
      Ectopic Tissue                                   1 (2%)                                                                       
      Hyperplasia, Nodular                             5 (10%)                   5 (10%)                                            
      Inflammation, Chronic                                                      2 (4%)                                             
   Salivary Glands                                    (50)                      (50)                                                
      Ectasia                                                                    1 (2%)                                             
      Inflammation, Chronic                            2 (4%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Edema                                            2 (4%)                    1 (2%)                                             
      Fibrosis                                                                   1 (2%)                                             
      Inflammation, Chronic                            2 (4%)                    2 (4%)                                             
      Inflammation, Suppurative                        1 (2%)                                                                       
      Mineralization                                   1 (2%)                                                                       
      Ulcer                                            1 (2%)       1 (2%)       1 (2%)                                             
      Mucosa, Dysplasia                                             1 (2%)                                                          
      Mucosa, Hyperplasia                              5 (10%)      2 (4%)       3 (6%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)                                                
      Cyst                                                          1 (2%)                                                          
      Edema                                            1 (2%)                                                                       
      Erosion                                                       1 (2%)       3 (6%)                                             
      Inflammation, Granulomatous                      1 (2%)                    1 (2%)                                             
      Mineralization                                   5 (10%)      8 (16%)      1 (2%)                                             
      Ulcer                                            1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Cardiomyopathy                                  20 (40%)     15 (30%)     19 (38%)                                            
      Thrombosis                                                                 1 (2%)                                             
      Epicardium, Inflammation, Chronic Active                                   1 (2%)                                             
      Myocardium, Inflammation, Chronic                7 (14%)      8 (16%)      1 (2%)                                             
      Myocardium, Mineralization                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Accessory Adrenal Cortical Nodule                8 (16%)      8 (16%)      3 (6%)                                             
      Angiectasis                                      5 (10%)      7 (14%)      8 (16%)                                            
      Basophilic Focus                                              1 (2%)       1 (2%)                                             
      Clear Cell Focus                                 9 (18%)     10 (20%)      8 (16%)                                            
      Cyst Multilocular                                             1 (2%)                                                          
      Hemorrhage                                                                 2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                      6 (12%)      5 (10%)      5 (10%)                                            
      Necrosis                                                                   3 (6%)                                             
      Vacuolization Cytoplasmic, Diffuse               1 (2%)       3 (6%)                                                          
   Adrenal Gland, Medulla                             (49)         (49)         (47)                                                
      Cyst                                             1 (2%)                                                                       
      Fibrosis                                         1 (2%)                                                                       
      Hyperplasia                                      1 (2%)       4 (8%)       1 (2%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
   Islets, Pancreatic                                 (48)         (2)          (50)                                                
      Hyperplasia                                                                1 (2%)                                             
   Pituitary Gland                                    (49)         (49)         (49)                                                
      Pars Distalis, Angiectasis                       3 (6%)       4 (8%)       8 (16%)                                            
      Pars Distalis, Cyst                             14 (29%)     15 (31%)      9 (18%)                                            
      Pars Distalis, Hyperplasia                       4 (8%)       4 (8%)      10 (20%)                                            
      Pars Distalis, Pigmentation                      1 (2%)       1 (2%)       2 (4%)                                             
      Pars Intermedia, Angiectasis                                  1 (2%)                                                          
      Pars Intermedia, Cyst                                         2 (4%)       1 (2%)                                             
      Pars Intermedia, Hyperplasia                                               1 (2%)                                             
      Pars Nervosa, Hyperplasia                        1 (2%)                    1 (2%)                                             
   Thyroid Gland                                      (50)         (4)          (50)                                                
      Ultimobranchial Cyst                             1 (2%)                    1 (2%)                                             
      C-Cell, Hyperplasia                              7 (14%)      1 (25%)      7 (14%)                                            
      Follicle, Cyst                                   1 (2%)       1 (25%)                                                         
      Follicular Cell, Hyperplasia                     1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (45)         (50)         (48)                                                
      Ectasia                                          6 (13%)      2 (4%)       7 (15%)                                            
      Hyperplasia                                      3 (7%)       1 (2%)       7 (15%)                                            
      Inflammation, Chronic                            6 (13%)      6 (12%)      4 (8%)                                             
      Inflammation, Suppurative                        6 (13%)      2 (4%)      12 (25%)                                            
      Metaplasia, Squamous                                                       1 (2%)                                             
   Ovary                                              (49)         (3)          (50)                                                
      Atrophy                                          1 (2%)                                                                       
      Cyst                                             4 (8%)       2 (67%)      7 (14%)                                            
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
   Uterus                                             (49)         (12)         (50)                                                
      Angiectasis                                                                1 (2%)                                             
      Cyst                                                          3 (25%)      1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Hemorrhage                                                    1 (8%)       2 (4%)                                             
      Hydrometra                                       2 (4%)       1 (8%)       1 (2%)                                             
      Hyperplasia, Cystic                              4 (8%)       1 (8%)       4 (8%)                                             
      Inflammation, Suppurative                        1 (2%)       1 (8%)       1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
      Endometrium, Dysplasia                                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (2)          (1)          (2)                                                 
      Anemia                                           1 (50%)      1 (100%)     2 (100%)                                           
      Leukocytosis                                     1 (50%)                                                                      
   Bone Marrow                                        (50)         (5)          (50)                                                
      Hyperplasia, Reticulum Cell                      3 (6%)       1 (20%)      5 (10%)                                            
      Myelofibrosis                                    1 (2%)                                                                       
      Proliferation                                    3 (6%)                                                                       
   Lymph Node                                         (50)         (1)          (50)                                                
      Mediastinal, Hyperplasia, Plasma Cell                                      1 (2%)                                             
   Lymph Node, Mandibular                             (46)                      (47)                                                
      Hyperplasia, Plasma Cell                         1 (2%)                    2 (4%)                                             
      Lymphatic, Dilatation                            2 (4%)                    1 (2%)                                             
   Lymph Node, Mesenteric                             (48)         (1)          (50)                                                
      Depletion Cellular                               1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                    2 (4%)                                             
      Pigmentation                                                               1 (2%)                                             
   Spleen                                             (50)         (50)         (50)                                                
      Congestion                                       1 (2%)       1 (2%)                                                          
      Fibrosis                                         1 (2%)       1 (2%)                                                          
      Hematopoietic Cell Proliferation                 6 (12%)     10 (20%)      4 (8%)                                             
      Hyperplasia, Re Cell                             1 (2%)                    1 (2%)                                             
      Necrosis                                                      2 (4%)                                                          
      Pigmentation, Hemosiderin                        3 (6%)       7 (14%)      7 (14%)                                            
      Lymphoid Follicle, Atrophy                                                 1 (2%)                                             
      Red Pulp, Atrophy                                1 (2%)                    1 (2%)                                             
   Thymus                                             (47)                      (46)                                                
      Cyst                                             1 (2%)                    1 (2%)                                             
      Fibrosis                                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)                                                
      Hyperplasia, Cystic                             43 (86%)     45 (90%)     32 (64%)                                            
      Hyperplasia, Lobular                             8 (16%)     10 (20%)      3 (6%)                                             
   Skin                                               (50)         (29)         (50)                                                
      Acanthosis                                       1 (2%)       1 (3%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Fibrosis                                         1 (2%)                                                                       
      Inflammation, Chronic                                         1 (3%)                                                          
      Inflammation, Suppurative                        1 (2%)                                                                       
      Ulcer                                            1 (2%)                                                                       
      Nipple, Hypertrophy                                           1 (3%)                                                          
      Subcutaneous Tissue, Inflammation,                                                                                            
          Granulomatous                                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Cranium, Hyperostosis                            6 (12%)      7 (14%)      1 (2%)                                             
      Femur, Hyperostosis                              7 (14%)      7 (14%)      1 (2%)                                             
      Sternum, Hyperostosis                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Compression                                      7 (14%)     16 (32%)      3 (6%)                                             
      Hemorrhage                                                                 2 (4%)                                             
      Hydrocephalus                                    2 (4%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic                                                      2 (4%)                                             
      Vacuolization Cytoplasmic                                                  1 (2%)                                             
   Peripheral Nerve                                   (47)         (50)         (49)                                                
      Inflammation, Chronic                            1 (2%)       1 (2%)       1 (2%)                                             
   Spinal Cord                                        (50)         (50)         (50)                                                
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Axon, White Matter, Degeneration                 1 (2%)                                                                       
      Gray Matter, Degeneration                        2 (4%)       1 (2%)       1 (2%)                                             
      Parenchyma, White Matter, Degeneration,                                                                                       
          Multifocal                                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Congestion                                       2 (4%)       2 (4%)       4 (8%)                                             
      Fibrosis                                         1 (2%)                                                                       
      Infiltration Cellular, Histiocyte               26 (52%)     14 (28%)     14 (28%)                                            
      Inflammation, Chronic                            1 (2%)       1 (2%)                                                          
      Inflammation, Suppurative                                                  1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 2 (4%)       2 (4%)       2 (4%)                                             
      Mediastinum, Inflammation, Chronic Active        1 (2%)                                                                       
      Subpleura, Inflammation, Chronic Active          1 (2%)                                                                       
   Nose                                               (50)                      (50)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Exudate                                          4 (8%)                    6 (12%)                                            
      Fungus                                           1 (2%)                                                                       
      Inflammation, Chronic                            2 (4%)                                                                       
      Mucosa, Hyperplasia                                                        1 (2%)                                             
      Mucosa, Metaplasia, Squamous                     2 (4%)                                                                       
   Trachea                                            (50)                      (50)                                                
      Exudate                                                                    1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Mucosa, Metaplasia, Squamous                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (49)                                                
      Cataract                                        21 (42%)     19 (38%)     25 (51%)                                            
      Hemorrhage                                                    1 (2%)                                                          
      Cornea, Inflammation, Chronic                                              1 (2%)                                             
      Cornea, Neovascularization                                                 1 (2%)                                             
      Retina, Atrophy                                 43 (86%)     42 (84%)     40 (82%)                                            
      Sclera, Mineralization                           5 (10%)     11 (22%)      6 (12%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Angiectasis                                                   1 (2%)                                                          
      Cyst                                                          2 (4%)                                                          
      Fibrosis                                                                   1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Hydronephrosis                                                2 (4%)                                                          
      Infarct                                          1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic                            3 (6%)       7 (14%)      1 (2%)                                             
      Inflammation, Suppurative                                     1 (2%)       3 (6%)                                             
      Mineralization                                  43 (86%)     45 (90%)     41 (82%)                                            
      Nephropathy                                     33 (66%)     41 (82%)     34 (68%)                                            
      Papilla, Necrosis                                             1 (2%)                                                          
      Renal Tubule, Cytoplasmic Alteration             1 (2%)                                                                       
      Renal Tubule, Degeneration                       2 (4%)       3 (6%)                                                          
      Renal Tubule, Dilatation                                                   2 (4%)                                             
      Renal Tubule, Necrosis                           1 (2%)                    1 (2%)                                             
      Renal Tubule, Pigmentation                                                 2 (4%)                                             
      Transitional Epithelium, Hyperplasia                          2 (4%)       2 (4%)                                             
   Urethra                                                                      (1)                                                 
      Calculus Micro Observation Only                                            1 (100%)                                           
      Inflammation, Suppurative                                                  1 (100%)                                           
      Mucosa, Hyperplasia                                                        1 (100%)                                           
   Urinary Bladder                                    (49)                      (49)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Edema                                            1 (2%)                                                                       
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Suppurative                                                  1 (2%)                                             
      Mineralization                                                             1 (2%)                                             
      Ulcer                                                                      1 (2%)                                             
      Mucosa, Hyperplasia                                                        3 (6%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          10           12           17                                                  
    Dead                                               3            9           12                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           29           21                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (49)         (48)         (47)                                                
      Edema                                                         2 (4%)       1 (2%)                                             
      Inflammation, Suppurative                                     1 (2%)       1 (2%)                                             
      Parasite Metazoan                                5 (10%)      4 (8%)       3 (6%)                                             
   Intestine Large, Colon                             (50)         (49)         (48)                                                
      Inflammation, Granulomatous                                                1 (2%)                                             
      Parasite Metazoan                                5 (10%)      3 (6%)       3 (6%)                                             
   Intestine Large, Rectum                            (49)         (49)         (45)                                                
      Mineralization                                                1 (2%)                                                          
      Parasite Metazoan                                9 (18%)      7 (14%)      4 (9%)                                             
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis                                                   4 (8%)       4 (8%)                                             
      Basophilic Focus                                37 (74%)     31 (62%)     20 (40%)                                            
      Clear Cell Focus                                15 (30%)     11 (22%)      5 (10%)                                            
      Congestion                                                    2 (4%)       1 (2%)                                             
      Degeneration, Cystic                                          2 (4%)       1 (2%)                                             
      Developmental Malformation                       7 (14%)      6 (12%)      6 (12%)                                            
      Eosinophilic Focus                                            1 (2%)                                                          
      Focal Cellular Change                            4 (8%)                    4 (8%)                                             
      Granuloma                                       23 (46%)     12 (24%)      1 (2%)                                             
      Hematopoietic Cell Proliferation                              6 (12%)      3 (6%)                                             
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Inflammation, Chronic                            2 (4%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic Active                     3 (6%)                    1 (2%)                                             
      Bile Duct, Cyst Multilocular                     1 (2%)       1 (2%)                                                          
      Bile Duct, Hyperplasia                          47 (94%)     45 (90%)     37 (74%)                                            
      Centrilobular, Atrophy                           2 (4%)       1 (2%)       4 (8%)                                             
      Centrilobular, Necrosis                                       4 (8%)       3 (6%)                                             
      Hepatocyte, Hyperplasia, Nodular                 3 (6%)       3 (6%)       5 (10%)                                            
      Hepatocyte, Vacuolization Cytoplasmic           15 (30%)     14 (28%)      2 (4%)                                             
      Kupffer Cell, Hyperplasia                                     4 (8%)       1 (2%)                                             
      Kupffer Cell, Pigmentation                                    2 (4%)                                                          
      Lobules, Necrosis                                1 (2%)       3 (6%)       2 (4%)                                             
   Mesentery                                          (16)         (22)         (19)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Accessory Spleen                                                           1 (5%)                                             
      Artery, Hypertrophy                              2 (13%)                   3 (16%)                                            
      Artery, Inflammation, Chronic Active             3 (19%)      1 (5%)       6 (32%)                                            
      Artery, Mineralization                                        1 (5%)                                                          
      Fat, Inflammation, Granulomatous                 3 (19%)     10 (45%)      3 (16%)                                            
      Fat, Mineralization                              8 (50%)     13 (59%)      9 (47%)                                            
      Fat, Necrosis                                   12 (75%)     15 (68%)     12 (63%)                                            
      Fat, Pigmentation                                             1 (5%)                                                          
   Pancreas                                           (49)         (49)         (48)                                                
      Atrophy                                         10 (20%)      9 (18%)      5 (10%)                                            
      Basophilic Focus                                                           2 (4%)                                             
      Hyperplasia, Nodular                             6 (12%)      6 (12%)     12 (25%)                                            
      Inflammation, Chronic                            4 (8%)                    1 (2%)                                             
      Inflammation, Granulomatous                      1 (2%)                                                                       
   Salivary Glands                                    (50)         (50)         (49)                                                
      Atrophy                                                       2 (4%)                                                          
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Inflammation, Suppurative                                                  1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Edema                                            1 (2%)       3 (6%)                                                          
      Erosion                                                                    1 (2%)                                             
      Inflammation, Chronic                            1 (2%)       1 (2%)       1 (2%)                                             
      Mineralization                                                2 (4%)       1 (2%)                                             
      Perforation                                      1 (2%)                                                                       
      Ulcer                                                         3 (6%)       1 (2%)                                             
      Mucosa, Dysplasia                                1 (2%)                                                                       
      Mucosa, Hyperplasia                              2 (4%)       3 (6%)       3 (6%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)                                                
      Edema                                            1 (2%)       1 (2%)                                                          
      Erosion                                          1 (2%)       2 (4%)       3 (6%)                                             
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Inflammation, Chronic                                         2 (4%)                                                          
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
      Mineralization                                   1 (2%)       6 (12%)      3 (6%)                                             
      Ulcer                                            2 (4%)                    2 (4%)                                             
      Mucosa, Dysplasia                                                          1 (2%)                                             
   Tongue                                             (1)                                                                           
      Hyperkeratosis                                   1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (1)          (1)                                                 
      Aorta, Fibrosis                                                            1 (100%)                                           
      Aorta, Hemorrhage                                                          1 (100%)                                           
      Aorta, Inflammation, Chronic                                               1 (100%)                                           
      Aorta, Mineralization                                         1 (100%)                                                        
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
   Heart                                              (50)         (50)         (50)                                                
      Cardiomyopathy                                  37 (74%)     42 (84%)     40 (80%)                                            
      Thrombosis                                       2 (4%)       4 (8%)       1 (2%)                                             
      Epicardium, Fibrosis                                                       1 (2%)                                             
      Epicardium, Inflammation, Chronic                1 (2%)                    1 (2%)                                             
      Myocardium, Inflammation, Chronic                             2 (4%)       5 (10%)                                            
      Myocardium, Mineralization                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Accessory Adrenal Cortical Nodule                4 (8%)      10 (20%)      8 (16%)                                            
      Angiectasis                                      5 (10%)      6 (12%)      1 (2%)                                             
      Basophilic Focus                                 2 (4%)                                                                       
      Clear Cell Focus                                 7 (14%)      6 (12%)      7 (14%)                                            
      Cyst                                                                       1 (2%)                                             
      Fibrosis                                                                   1 (2%)                                             
      Hematopoietic Cell Proliferation                              4 (8%)                                                          
      Hyperplasia                                      2 (4%)       9 (18%)      3 (6%)                                             
      Necrosis                                                                   1 (2%)                                             
      Vacuolization Cytoplasmic, Diffuse                            6 (12%)      4 (8%)                                             
   Adrenal Gland, Medulla                             (49)         (50)         (49)                                                
      Hyperplasia                                      2 (4%)       6 (12%)      3 (6%)                                             
      Infiltration Cellular, Mononuclear Cell                       1 (2%)                                                          
   Islets, Pancreatic                                 (49)         (48)         (48)                                                
      Hyperplasia                                      3 (6%)                                                                       
   Parathyroid Gland                                  (48)         (46)         (46)                                                
      Hyperplasia                                      1 (2%)                                                                       
   Pituitary Gland                                    (49)         (50)         (49)                                                
      Pars Distalis, Angiectasis                       4 (8%)       1 (2%)                                                          
      Pars Distalis, Cyst                              1 (2%)       6 (12%)      2 (4%)                                             
      Pars Distalis, Hyperplasia                       4 (8%)      10 (20%)      8 (16%)                                            
      Pars Intermedia, Angiectasis                                  1 (2%)                                                          
      Pars Intermedia, Cyst                                         2 (4%)       1 (2%)                                             
      Pars Nervosa, Hyperplasia                                                  1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (49)                                                
      Concretion                                                    1 (2%)                                                          
      Mineralization                                                1 (2%)                                                          
      Pigmentation                                    18 (36%)     19 (38%)     10 (20%)                                            
      Ultimobranchial Cyst                                          1 (2%)       1 (2%)                                             
      C-Cell, Hyperplasia                              7 (14%)     15 (30%)      4 (8%)                                             
      Follicle, Cyst                                   2 (4%)       2 (4%)       1 (2%)                                             
      Follicular Cell, Hyperplasia                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)                                                              
      Hemorrhage                                                    1 (100%)                                                        
      Infiltration Cellular, Mononuclear Cell                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (50)         (49)                                                
      Fibrosis                                                      1 (2%)                                                          
      Pigmentation                                                  1 (2%)                                                          
   Preputial Gland                                    (50)         (50)         (50)                                                
      Ectasia                                          1 (2%)       4 (8%)       5 (10%)                                            
      Hyperplasia                                                   1 (2%)       1 (2%)                                             
      Inflammation, Chronic                           35 (70%)     25 (50%)     25 (50%)                                            
      Inflammation, Suppurative                        4 (8%)       9 (18%)      6 (12%)                                            
      Metaplasia, Squamous                                          2 (4%)                                                          
      Mineralization                                                             1 (2%)                                             
      Necrosis                                                      1 (2%)                                                          
   Prostate                                           (50)         (50)         (50)                                                
      Corpora Amylacea                                 2 (4%)       6 (12%)      1 (2%)                                             
      Ectasia                                          1 (2%)                                                                       
      Fibrosis                                         4 (8%)       4 (8%)                                                          
      Inflammation, Chronic                           10 (20%)     21 (42%)      5 (10%)                                            
      Inflammation, Suppurative                       20 (40%)     27 (54%)      6 (12%)                                            
   Testes                                             (50)         (50)         (49)                                                
      Mineralization                                  24 (48%)     23 (46%)     11 (22%)                                            
      Spermatocele                                     1 (2%)                                                                       
      Interstitial Cell, Hyperplasia                   1 (2%)                    2 (4%)                                             
      Seminiferous Tubule, Atrophy                     2 (4%)       7 (14%)      7 (14%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (1)                                                                           
      Anemia                                           1 (100%)                                                                     
      Leukocytosis                                     1 (100%)                                                                     
   Bone Marrow                                        (50)         (50)         (50)                                                
      Angiectasis                                      1 (2%)       1 (2%)       1 (2%)                                             
      Depletion Cellular                                            1 (2%)                                                          
      Hyperplasia, Reticulum Cell                      1 (2%)                    1 (2%)                                             
      Myelofibrosis                                                              1 (2%)                                             
      Proliferation                                                 9 (18%)      3 (6%)                                             
   Lymph Node                                         (50)         (50)         (50)                                                
      Inguinal, Hyperplasia, Lymphoid                  1 (2%)                                                                       
      Mediastinal, Erythrophagocytosis                 2 (4%)       1 (2%)                                                          
      Mediastinal, Hemorrhage                          1 (2%)       2 (4%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Mediastinal, Hyperplasia, Plasma Cell                                      1 (2%)                                             
      Mediastinal, Hyperplasia, Reticulum Cell                      1 (2%)                                                          
      Mediastinal, Infiltration Cellular, Mast Cell                 1 (2%)                                                          
      Mediastinal, Pigmentation                                     3 (6%)                                                          
   Lymph Node, Mandibular                             (49)         (48)         (46)                                                
      Depletion Cellular                                            1 (2%)                                                          
      Erythrophagocytosis                              1 (2%)       1 (2%)                                                          
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Hyperplasia, Plasma Cell                         3 (6%)       2 (4%)       5 (11%)                                            
      Hyperplasia, Reticulum Cell                                   1 (2%)                                                          
      Lymphatic, Dilatation                            5 (10%)      1 (2%)       3 (7%)                                             
   Lymph Node, Mesenteric                             (50)         (49)         (48)                                                
      Depletion Cellular                                            1 (2%)                                                          
      Erythrophagocytosis                                           2 (4%)                                                          
      Hemorrhage                                       1 (2%)       1 (2%)       3 (6%)                                             
      Infiltration Cellular, Mast Cell                              2 (4%)       1 (2%)                                             
      Pigmentation                                    38 (76%)     33 (67%)     26 (54%)                                            
   Spleen                                             (50)         (50)         (50)                                                
      Congestion                                                    1 (2%)                                                          
      Fibrosis                                         2 (4%)       1 (2%)       3 (6%)                                             
      Hematopoietic Cell Proliferation                 6 (12%)     11 (22%)      6 (12%)                                            
      Hyperplasia, Re Cell                             1 (2%)       1 (2%)                                                          
      Necrosis                                                                   1 (2%)                                             
      Pigmentation, Hemosiderin                        1 (2%)       5 (10%)      2 (4%)                                             
      Lymphoid Follicle, Atrophy                                    2 (4%)       2 (4%)                                             
      Red Pulp, Atrophy                                             3 (6%)       4 (8%)                                             
   Thymus                                             (47)         (30)         (49)                                                
      Cyst                                             2 (4%)                                                                       
      Hemorrhage                                                                 1 (2%)                                             
      Epithelial Cell, Hyperplasia                     1 (2%)       2 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (47)         (47)         (44)                                                
      Hyperplasia, Cystic                             16 (34%)     16 (34%)      7 (16%)                                            
      Hyperplasia, Lobular                             2 (4%)       5 (11%)      1 (2%)                                             
      Inflammation, Granulomatous                                   1 (2%)                                                          
   Skin                                               (50)         (49)         (50)                                                
      Acanthosis                                                    1 (2%)                                                          
      Cyst Epithelial Inclusion                        1 (2%)       6 (12%)      2 (4%)                                             
      Cyst Multilocular                                             1 (2%)                                                          
      Fibrosis                                         2 (4%)                                                                       
      Foreign Body                                                  1 (2%)                                                          
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Chronic                                         1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Inflammation, Suppurative                        1 (2%)       1 (2%)       2 (4%)                                             
      Mineralization                                                             2 (4%)                                             
      Ulcer                                                                      2 (4%)                                             
      Hair Follicle, Atrophy                                        1 (2%)                                                          
      Sebaceous Gland, Ectasia                         1 (2%)                                                                       
      Subcutaneous Tissue, Edema                                    1 (2%)                                                          
      Subcutaneous Tissue, Fibrosis                    2 (4%)                                                                       
      Subcutaneous Tissue, Granuloma                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Cranium, Hyperostosis                                         1 (2%)                                                          
   Skeletal Muscle                                    (1)          (4)          (3)                                                 
      Edema                                                         1 (25%)                                                         
      Hemorrhage                                                                 1 (33%)                                            
      Inflammation, Chronic                                                      1 (33%)                                            
      Inflammation, Chronic Active                                  1 (25%)                                                         
      Mineralization                                                             1 (33%)                                            
      Necrosis                                                                   1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Compression                                      2 (4%)       2 (4%)       1 (2%)                                             
      Corpora Amylacea                                                           1 (2%)                                             
      Developmental Malformation                                    1 (2%)                                                          
      Hemorrhage                                                    2 (4%)       2 (4%)                                             
      Hydrocephalus                                    2 (4%)       1 (2%)                                                          
      Inflammation, Chronic                                                      1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
   Peripheral Nerve                                   (49)         (49)         (46)                                                
      Infiltration Cellular, Mast Cell                              1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)       1 (2%)                                                          
      Axon, Hypertrophy                                             2 (4%)                                                          
   Spinal Cord                                        (50)         (50)         (50)                                                
      Gray Matter, Cytoplasmic Alteration                           1 (2%)                                                          
      Gray Matter, Degeneration                        1 (2%)       1 (2%)       1 (2%)                                             
      Gray Matter, Necrosis                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Adenomatosis                                     1 (2%)       1 (2%)       1 (2%)                                             
      Congestion                                       1 (2%)       4 (8%)       8 (16%)                                            
      Foreign Body                                     1 (2%)       1 (2%)                                                          
      Hemorrhage                                       1 (2%)                                                                       
      Infiltration Cellular, Histiocyte               18 (36%)     14 (28%)      9 (18%)                                            
      Inflammation, Chronic                            1 (2%)       1 (2%)       2 (4%)                                             
      Leukocytosis                                                               1 (2%)                                             
      Mineralization                                   1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 2 (4%)       3 (6%)       4 (8%)                                             
      Alveolus, Edema                                  1 (2%)       1 (2%)       3 (6%)                                             
      Artery, Mediastinum, Hypertrophy                 1 (2%)                    1 (2%)                                             
      Artery, Mediastinum, Inflammation, Chronic                                                                                    
          Active                                       1 (2%)                    1 (2%)                                             
      Lymphatic, Dilatation                                         1 (2%)                                                          
      Mediastinum, Edema                                            1 (2%)                                                          
   Nose                                               (50)         (50)         (50)                                                
      Exudate                                         14 (28%)      9 (18%)      8 (16%)                                            
      Foreign Body                                     1 (2%)       3 (6%)       3 (6%)                                             
      Fungus                                          10 (20%)      4 (8%)       2 (4%)                                             
      Inflammation, Chronic                            7 (14%)      3 (6%)       4 (8%)                                             
      Mucosa, Hyperplasia                              3 (6%)       2 (4%)       2 (4%)                                             
      Mucosa, Metaplasia, Squamous                     5 (10%)      5 (10%)      2 (4%)                                             
   Trachea                                            (50)         (50)         (50)                                                
      Inflammation, Chronic                                         2 (4%)                                                          
      Mineralization                                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (45)                                                
      Cataract                                         9 (18%)      3 (6%)      10 (22%)                                            
      Hemorrhage                                                    1 (2%)                                                          
      Cornea, Inflammation, Chronic                                 1 (2%)                                                          
      Cornea, Mineralization                           1 (2%)                                                                       
      Retina, Atrophy                                 31 (62%)     28 (56%)     35 (78%)                                            
      Sclera, Mineralization                          25 (50%)     26 (52%)     20 (44%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Angiectasis                                                   1 (2%)                                                          
      Cyst                                             1 (2%)                                                                       
      Fibrosis                                                      1 (2%)                                                          
      Glomerulosclerosis                                            1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05006-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Hydronephrosis                                                1 (2%)       1 (2%)                                             
      Infarct                                                                    3 (6%)                                             
      Inflammation, Chronic                           29 (58%)     30 (60%)     32 (64%)                                            
      Inflammation, Suppurative                        9 (18%)     13 (26%)     13 (26%)                                            
      Mineralization                                   8 (16%)     15 (30%)     10 (20%)                                            
      Nephropathy                                     50 (100%)    49 (98%)     44 (88%)                                            
      Capsule, Fibrosis                                1 (2%)                                                                       
      Renal Tubule, Cytoplasmic Alteration             1 (2%)                                                                       
      Renal Tubule, Degeneration                                    1 (2%)                                                          
      Renal Tubule, Hyperplasia                        1 (2%)                    1 (2%)                                             
      Renal Tubule, Necrosis                                                     2 (4%)                                             
      Renal Tubule, Pigmentation                                    2 (4%)       3 (6%)                                             
      Transitional Epithelium, Hyperplasia             1 (2%)                    5 (10%)                                            
      Venule, Infiltration Cellular, Histiocyte                     1 (2%)                                                          
      Venule, Pigmentation                                          1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           

--multipart-boundary
Content-type: text/plain
Range: bytes 106347-106347/106347


--multipart-boundary--