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TDMS Study 05006-05 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                            BENZALDEHYDE


NTP Experiment-Test: 05006-05                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/03/94
Route: GAVAGE                                                                                                     Time: 08:49:08




       Facility:  Southern Research Institute

       Chemical CAS #:  000100527

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05006-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          13           16           12                                                  
    Dead                                               4            1            9                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           33           29                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (49)         (1)          (50)                                                
   Intestine Large, Colon                             (49)         (1)          (50)                                                
   Intestine Small, Duodenum                          (49)         (1)          (46)                                                
   Intestine Small, Ileum                             (48)         (1)          (44)                                                
   Intestine Small, Jejunum                           (48)         (2)          (47)                                                
      Schwannoma Malignant                                          1 (50%)                                                         
   Liver                                              (50)         (50)         (50)                                                
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Neoplastic Nodule                                5 (10%)                   1 (2%)                                             
      Schwannoma Malignant                             1 (2%)                                                                       
   Mesentery                                          (9)          (5)          (6)                                                 
      Sarcoma, Metastatic, Vagina                      1 (11%)                                                                      
   Pancreas                                           (48)         (2)          (50)                                                
      Adenoma                                                                    1 (2%)                                             
      Fibrous Histiocytoma                                          1 (50%)                                                         
   Pharynx                                            (1)                                                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
   Salivary Glands                                    (50)                      (50)                                                
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Squamous Cell Papilloma                                                    2 (4%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05006-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Adenoma                                                       2 (4%)       2 (4%)                                             
   Adrenal Gland, Medulla                             (49)         (49)         (47)                                                
      Pheochromocytoma Malignant                       2 (4%)                    2 (4%)                                             
      Pheochromocytoma Benign                          5 (10%)      2 (4%)       3 (6%)                                             
      Bilateral, Pheochromocytoma Benign                            1 (2%)                                                          
   Islets, Pancreatic                                 (48)         (2)          (50)                                                
      Adenoma                                          1 (2%)       2 (100%)                                                        
   Pituitary Gland                                    (49)         (49)         (49)                                                
      Adenoma                                         23 (47%)     31 (63%)     15 (31%)                                            
      Carcinoma                                        3 (6%)       2 (4%)       1 (2%)                                             
      Pars Intermedia, Adenoma                         1 (2%)                    1 (2%)                                             
   Thyroid Gland                                      (50)         (4)          (50)                                                
      C-Cell, Adenoma                                  2 (4%)       1 (25%)      3 (6%)                                             
      C-Cell, Carcinoma                                             1 (25%)                                                         
      Follicular Cell, Adenoma                                                   1 (2%)                                             
      Follicular Cell, Carcinoma                                    2 (50%)      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (45)         (50)         (48)                                                
      Adenoma                                          1 (2%)       3 (6%)       1 (2%)                                             
      Basosquamous Tumor Malignant                                               1 (2%)                                             
      Carcinoma                                        1 (2%)                    1 (2%)                                             
   Ovary                                              (49)         (3)          (50)                                                
   Uterus                                             (49)         (12)         (50)                                                
      Adenoma                                                                    1 (2%)                                             
      Polyp Stromal                                   12 (24%)      8 (67%)     14 (28%)                                            
      Sarcoma Stromal                                  1 (2%)                                                                       
   Vagina                                             (7)          (4)          (2)                                                 
      Sarcoma                                          1 (14%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (2)          (1)          (2)                                                 
   Bone Marrow                                        (50)         (5)          (50)                                                
      Fibrous Histiocytoma                                          1 (20%)                                                         
   Lymph Node                                         (50)         (1)          (50)                                                
      Mediastinal, Fibrous Histiocytoma                             1 (100%)                                                        
                                                             Page   3                                                               
NTP Experiment-Test: 05006-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Lymph Node, Mandibular                             (46)                      (47)                                                
   Lymph Node, Mesenteric                             (48)         (1)          (50)                                                
      Fibrous Histiocytoma                                          1 (100%)                                                        
   Spleen                                             (50)         (50)         (50)                                                
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Hemangiosarcoma                                  1 (2%)                                                                       
      Sarcoma                                                                    1 (2%)                                             
   Thymus                                             (47)                      (46)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)                                                
      Adenoma                                          1 (2%)       2 (4%)                                                          
      Carcinoma                                        1 (2%)                    2 (4%)                                             
      Fibroadenoma                                    28 (56%)     28 (56%)     22 (44%)                                            
   Skin                                               (50)         (29)         (50)                                                
      Papilloma                                                                  2 (4%)                                             
      Subcutaneous Tissue, Fibroma                                  3 (10%)                                                         
      Subcutaneous Tissue, Lipoma                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (1)          (1)                                                 
      Fibrous Histiocytoma                                          1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)       1 (2%)                                                          
      Meningioma Malignant                             1 (2%)                                                                       
      Oligodendroglioma Malignant                      1 (2%)                                                                       
   Spinal Cord                                        (50)         (50)         (50)                                                
      Schwannoma Malignant                                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
      Fibrous Histiocytoma                                          1 (2%)                                                          
   Nose                                               (50)                      (50)                                                
   Trachea                                            (50)                      (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05006-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
   Urinary Bladder                                    (49)                      (49)                                                
      Sarcoma, Metastatic, Vagina                      1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            15 (30%)     20 (40%)     18 (36%)                                            
      Lymphoma Malignant Lymphocytic                   1 (2%)                    1 (2%)                                             
      Lymphoma Malignant Mixed                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05006-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            46          48          43                                                   
     Total Primary Neoplasms                          111         119          97                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 42          46          37                                                   
     Total Benign Neoplasms                            81          83          69                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              25          27          24                                                   
     Total Malignant Neoplasms                         30          36          28                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           2                                                               
     Total Metastatic Neoplasm                          3           2                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05006-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          10           12           17                                                  
    Dead                                               3            9           12                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           29           21                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (47)         (50)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
   Intestine Large, Cecum                             (49)         (48)         (47)                                                
      Fibrosarcoma                                     1 (2%)                                                                       
   Intestine Small, Jejunum                           (49)         (50)         (48)                                                
      Schwannoma Malignant                             1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Uncertain Primary Site                 1 (2%)                                                          
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Hepatocellular Carcinoma                                      1 (2%)                                                          
      Neoplastic Nodule                                2 (4%)                    1 (2%)                                             
   Mesentery                                          (16)         (22)         (19)                                                
      Carcinoma, Metastatic, Uncertain Primary Site                 1 (5%)                                                          
      Liposarcoma                                      1 (6%)                                                                       
   Pancreas                                           (49)         (49)         (48)                                                
      Adenoma                                          3 (6%)       2 (4%)       7 (15%)                                            
   Pharynx                                                                      (1)                                                 
      Squamous Cell Papilloma                                                    1 (100%)                                           
   Salivary Glands                                    (50)         (50)         (49)                                                
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                    1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)                                                
   Stomach, Glandular                                 (50)         (50)         (50)                                                
      Carcinoma                                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Squamous Cell Carcinoma, Metastatic,                                                                                          
          Zymbal's Gland                                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05006-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Adenoma                                          1 (2%)       1 (2%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
      Carcinoma                                                                  1 (2%)                                             
   Adrenal Gland, Medulla                             (49)         (50)         (49)                                                
      Pheochromocytoma Malignant                       2 (4%)       5 (10%)      5 (10%)                                            
      Pheochromocytoma Benign                         14 (29%)     16 (32%)     13 (27%)                                            
      Bilateral, Pheochromocytoma Benign               3 (6%)       3 (6%)       1 (2%)                                             
   Islets, Pancreatic                                 (49)         (48)         (48)                                                
      Adenoma                                          4 (8%)       8 (17%)      1 (2%)                                             
      Carcinoma                                        1 (2%)       1 (2%)       1 (2%)                                             
   Pituitary Gland                                    (49)         (50)         (49)                                                
      Adenoma                                         15 (31%)     22 (44%)     11 (22%)                                            
      Carcinoma                                        3 (6%)                    3 (6%)                                             
      Carcinoma, Metastatic, Preputial Gland                        1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (49)                                                
      C-Cell, Adenoma                                  4 (8%)       8 (16%)      7 (14%)                                            
      C-Cell, Carcinoma                                1 (2%)       2 (4%)       1 (2%)                                             
      Follicular Cell, Adenoma                                      2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (50)         (50)         (50)                                                
      Adenoma                                          1 (2%)       3 (6%)       3 (6%)                                             
      Carcinoma                                        1 (2%)       4 (8%)       4 (8%)                                             
   Prostate                                           (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
      Carcinoma, Metastatic, Uncertain Primary Site                 1 (2%)                                                          
   Seminal Vesicle                                                 (2)          (2)                                                 
      Carcinoma, Metastatic, Uncertain Primary Site                 1 (50%)                                                         
   Testes                                             (50)         (50)         (49)                                                
      Bilateral, Interstitial Cell, Adenoma           40 (80%)     38 (76%)     24 (49%)                                            
      Interstitial Cell, Adenoma                       6 (12%)      9 (18%)      7 (14%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05006-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (1)                                                                           
   Bone Marrow                                        (50)         (50)         (50)                                                
      Fibrous Histiocytoma                                          1 (2%)                                                          
   Lymph Node                                         (50)         (50)         (50)                                                
   Lymph Node, Mandibular                             (49)         (48)         (46)                                                
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)       1 (2%)                                             
   Lymph Node, Mesenteric                             (50)         (49)         (48)                                                
   Spleen                                             (50)         (50)         (50)                                                
      Hemangiosarcoma                                               1 (2%)                                                          
      Leiomyosarcoma                                   1 (2%)                                                                       
      Schwannoma Malignant                                          1 (2%)                                                          
   Thymus                                             (47)         (30)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (47)         (47)         (44)                                                
      Adenoma                                                       1 (2%)                                                          
      Carcinoma                                        1 (2%)                                                                       
      Fibroadenoma                                     3 (6%)       2 (4%)       1 (2%)                                             
   Skin                                               (50)         (49)         (50)                                                
      Basal Cell Carcinoma                                          2 (4%)                                                          
      Keratoacanthoma                                  1 (2%)                    4 (8%)                                             
      Papilloma                                                     1 (2%)       3 (6%)                                             
      Sebaceous Gland, Carcinoma                                    1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     5 (10%)      3 (6%)       3 (6%)                                             
      Subcutaneous Tissue, Fibrosarcoma                2 (4%)       1 (2%)       2 (4%)                                             
      Subcutaneous Tissue, Fibrous Histiocytoma                                  1 (2%)                                             
      Subcutaneous Tissue, Lipoma                                   1 (2%)                                                          
      Subcutaneous Tissue, Liposarcoma                              1 (2%)                                                          
      Subcutaneous Tissue, Myxosarcoma                              2 (4%)                                                          
      Subcutaneous Tissue, Sarcoma                                  1 (2%)                                                          
      Subcutaneous Tissue, Schwannoma Benign           1 (2%)                                                                       
      Subcutaneous Tissue, Schwannoma Malignant        1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Osteosarcoma                                                               1 (2%)                                             
   Skeletal Muscle                                    (1)          (4)          (3)                                                 
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (100%)                                                                     
      Carcinoma, Metastatic, Thyroid Gland                          1 (25%)                                                         
      Hemangiosarcoma                                                            1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                             Page   9                                                               
NTP Experiment-Test: 05006-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Preputial Gland                        1 (2%)                                                          
      Granular Cell Tumor Benign                       1 (2%)                    1 (2%)                                             
      Sarcoma, Metastatic, Skin                                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                                  1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma                   2 (4%)       1 (2%)                                                          
      Carcinoma, Metastatic, Preputial Gland                        1 (2%)                                                          
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)       1 (2%)                                             
      Carcinoma, Metastatic, Uncertain Primary Site                 1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic,                                                                                          
          Zymbal's Gland                                                         1 (2%)                                             
   Nose                                               (50)         (50)         (50)                                                
   Trachea                                            (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)                       (2)                                                 
      Squamous Cell Carcinoma                          1 (100%)                  2 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
   Urinary Bladder                                    (49)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            10 (20%)     17 (34%)     16 (32%)                                            
      Lymphoma Malignant Histiocytic                                             1 (2%)                                             
      Lymphoma Malignant Lymphocytic                                             1 (2%)                                             
      Mesothelioma Malignant                                        5 (10%)      2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05006-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 08:49:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      200.         400.                                                   
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          50          42                                                   
     Total Primary Neoplasms                          133         170         133                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 48          49          38                                                   
     Total Benign Neoplasms                           104         121          90                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              24          34          33                                                   
     Total Malignant Neoplasms                         29          49          43                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           4           4                                                   
     Total Metastatic Neoplasm                          5          12           7                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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