Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/3136

TDMS Study 05006-05 Pathology Tables

NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97
Route: GAVAGE                                                                                                     Time: 09:26:06




       Facility:  Southern Research Institute

       Chemical CAS #:  000100527

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 7| 1| 3| 3| 1| 3| 3| 3| 3| 2| 9| 3| 3| 3| 6| 3| 3| 3| 3| 7| 0| 3| 3| 3|             
                                           | 2| 4| 1| 2| 2| 5| 1| 1| 1| 2| 0| 8| 1| 1| 2| 4| 2| 2| 2| 2| 4| 1| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                              X                           |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X     X  X  X  X     X     X  X     X  X  X  X|             
      Clear Cell Focus                     |                                                                          |             
      Developmental Malformation           |       X                                                                  |             
      Focal Cellular Change                |                                                                          |             
      Granuloma                            |       1        3     2                    2                       1  2   |             
      Hematopoietic Cell Proliferation     | 1                                2                                       |             
      Inflammation, Chronic                | 2     2                             1                                    |             
      Mixed Cell Focus                     |                                                             X            |             
      Bile Duct, Cyst Multilocular         |             X                                                            |             
      Bile Duct, Hyperplasia               | 1  1     1  1     1     1        1     1           2           1         |             
      Centrilobular, Atrophy               |                                                                          |             
      Hepatocyte, Hyperplasia, Nodular     |                                                    3                     |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
      Kupffer Cell, Pigmentation           |                2                                                         |             
      Lobules, Necrosis                    |                               2  1                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +              +                       +   |             
      Infiltration Cellular, Histiocyte    |                                                                      3   |             
      Fat, Inflammation, Granulomatous     |                                                                          |             
      Fat, Necrosis                        |                               4              2                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                            2                                         2   |             
      Ectopic Tissue                       |                         X                                                |             
      Hyperplasia, Nodular                 |                                     1                 3                 2|             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                            1                                1            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                3                                                         |             
      Inflammation, Chronic                |                3     3                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 7| 1| 3| 3| 1| 3| 3| 3| 3| 2| 9| 3| 3| 3| 6| 3| 3| 3| 3| 7| 0| 3| 3| 3|             
                                           | 2| 4| 1| 2| 2| 5| 1| 1| 1| 2| 0| 8| 1| 1| 2| 4| 2| 2| 2| 2| 4| 1| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                      3                                                   |             
      Mineralization                       |                                  2                                       |             
      Ulcer                                |                   3                                                      |             
      Mucosa, Hyperplasia                  |                   3  3     1                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                2                                                         |             
      Inflammation, Granulomatous          |                                                                          |             
      Mineralization                       |                                  2                             2         |             
      Ulcer                                |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2     3                          1     2     2        2     1  1     3|             
      Myocardium, Inflammation, Chronic    |                      1                                               1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |       X           X  X           X                                       |             
      Angiectasis                          |          2                                            2                 2|             
      Clear Cell Focus                     |             X                             X              X  X     X      |             
      Hyperplasia                          |          1                                                        3      |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                      X   |             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          |                                                       2                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |             3                                                            |             
      Pars Distalis, Cyst                  |       X                 X  X     X  X        X                       X   |             
      Pars Distalis, Hyperplasia           |             2           3  3                                             |             
      Pars Distalis, Pigmentation          |                                                                          |             
      Pars Nervosa, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |                      1                          3     1                  |             
      Follicle, Cyst                       |                                                             X            |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 7| 1| 3| 3| 1| 3| 3| 3| 3| 2| 9| 3| 3| 3| 6| 3| 3| 3| 3| 7| 0| 3| 3| 3|             
                                           | 2| 4| 1| 2| 2| 5| 1| 1| 1| 2| 0| 8| 1| 1| 2| 4| 2| 2| 2| 2| 4| 1| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Ectasia                              |                4                                                         |             
      Hyperplasia                          |                2                          3                              |             
      Inflammation, Chronic                |          2  2                 2           3                              |             
      Inflammation, Suppurative            |             2                             3                              |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                    X           X         |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                               4     2                                    |             
      Hyperplasia, Cystic                  |                                                 2  2                     |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |       +     +                                               +            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |             +                    +                                       |             
      Anemia                               |                                  3                                       |             
      Leukocytosis                         |             X                                                            |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Reticulum Cell          |                                        3                                 |             
      Myelofibrosis                        |                                                                          |             
      Proliferation                        |             3                    3                          3            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Lymphatic, Dilatation                |                                                                   3      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |                                                                          |             
      Hemorrhage                           |                                                                3         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                              3                           |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     | 2           4                 3  3                                       |             
      Hyperplasia, Re Cell                 |                                                                          |             
      Pigmentation, Hemosiderin            |                3                                                         |             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Cyst                                 |                         X                                                |             
      Fibrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 7| 1| 3| 3| 1| 3| 3| 3| 3| 2| 9| 3| 3| 3| 6| 3| 3| 3| 3| 7| 0| 3| 3| 3|             
                                           | 2| 4| 1| 2| 2| 5| 1| 1| 1| 2| 0| 8| 1| 1| 2| 4| 2| 2| 2| 2| 4| 1| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |    3  2  3     3  4  4  3  2  2  2  2  3  3     3  3  3  3  2  3  3  2  2|             
      Hyperplasia, Lobular                 |          3                 4                                      2  2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Fibrosis                             |                                                                          |             
      Inflammation, Suppurative            |                                                                      3   |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hyperostosis                |                      X                             X                     |             
      Femur, Hyperostosis                  |                      X                 X           X                     |             
      Sternum, Hyperostosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    X  X        X                                                         |             
      Hydrocephalus                        |                2                                                         |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |    1                                                                     |             
      Axon, White Matter, Degeneration     |                                                                          |             
      Gray Matter, Degeneration            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                              2                           |             
      Fibrosis                             |                               2                                          |             
      Infiltration Cellular, Histiocyte    |       1  1  1     1     1        1  1     1        1  1        1  2  1  1|             
      Inflammation, Chronic                |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                      3   |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
      Subpleura, Inflammation, Chronic     |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                        X                          X      |             
      Fungus                               |                                                                   X      |             
      Inflammation, Chronic                |                                                                   2      |             
      Mucosa, Metaplasia, Squamous         |                                                                   2      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 7| 1| 3| 3| 1| 3| 3| 3| 3| 2| 9| 3| 3| 3| 6| 3| 3| 3| 3| 7| 0| 3| 3| 3|             
                                           | 2| 4| 1| 2| 2| 5| 1| 1| 1| 2| 0| 8| 1| 1| 2| 4| 2| 2| 2| 2| 4| 1| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |    1  1        1  1  1  1                 1        1              1  2  1|             
      Retina, Atrophy                      | 2     3  3  3  2  3  3  3  3     2  3  1  3     2  3  2  2  3  2  3  3  3|             
      Sclera, Mineralization               |                1                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                        2                                 |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       | 2     2  2  2  2  2  2  1  1  3  2  2  2  1  2        3  2  1     1  2  3|             
      Nephropathy                          |       1     2  2  1  2  1  1     1           1  1  1           1  1     1|             
      Renal Tubule, Cytoplasmic Alteration |                                                                          |             
      Renal Tubule, Degeneration           |                                                                          |             
      Renal Tubule, Necrosis               |                               2                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 3| 1| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 9| 3| 3| 3| 7| 8| 3| 3| 3|            |
                                           | 4| 0| 2| 2| 2| 9| 2| 2| 2| 2| 3| 3| 3| 3| 3| 8| 5| 2| 2| 2| 9| 1| 2| 2| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                 X                        |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                   X                 X                 X                  |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
      Parasite Metazoan                    |                                                       X  X        X      |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                         3|      1  3.0|
      Basophilic Focus                     |       X  X  X  X  X  X  X  X     X  X  X  X     X  X  X  X     X  X  X  X|     41     |
      Clear Cell Focus                     |                         X                 X                              |      2     |
      Developmental Malformation           |    X                    X                                   X            |      4     |
      Focal Cellular Change                |    X                             X                    X                  |      3     |
      Granuloma                            |    4              3        3  2     1     2                    1         |     13  2.1|
      Hematopoietic Cell Proliferation     |                                                                          |      2  1.5|
      Inflammation, Chronic                |                                        1                                 |      4  1.5|
      Mixed Cell Focus                     |                                                                          |      1     |
      Bile Duct, Cyst Multilocular         |                                                                          |      1     |
      Bile Duct, Hyperplasia               |    1        1  2  1  1        1  1     1        1  1        1  1  1  1  1|     25  1.1|
      Centrilobular, Atrophy               | 2                                                                        |      1  2.0|
      Hepatocyte, Hyperplasia, Nodular     |                2                                                         |      2  2.5|
      Hepatocyte, Vacuolization Cytoplasmic|    2                          2              4                           |      3  2.7|
      Kupffer Cell, Pigmentation           |                                                             3            |      2  2.5|
      Lobules, Necrosis                    |                                                          1               |      3  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                 +  +                    +              +  +         |   9        |
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
      Fat, Inflammation, Granulomatous     |                         3                                      3         |      2  3.0|
      Fat, Necrosis                        |    3                 3  4                                      3         |      6  3.2|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                            1        1                                    |      4  1.5|
      Ectopic Tissue                       |                                                                          |      1     |
      Hyperplasia, Nodular                 |                1  2                                                      |      5  1.8|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                         +|   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 3| 1| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 9| 3| 3| 3| 7| 8| 3| 3| 3|            |
                                           | 4| 0| 2| 2| 2| 9| 2| 2| 2| 2| 3| 3| 3| 3| 3| 8| 5| 2| 2| 2| 9| 1| 2| 2| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                2         |      2  2.5|
      Inflammation, Chronic                |                                                                          |      2  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  3.0|
      Mucosa, Hyperplasia                  |                      1                             1                     |      5  1.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |       1                                                                  |      1  1.0|
      Mineralization                       |       2  2  1                                                            |      5  1.8|
      Ulcer                                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |       2     2        1  2  1           1  3        2     2     2        1|     20  1.8|
      Myocardium, Inflammation, Chronic    |                            1  1                 1        1           1   |      7  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                               X                    X     X  X            |      8     |
      Angiectasis                          |       2  2                                                               |      5  2.0|
      Clear Cell Focus                     |    X  X        X     X                                                   |      9     |
      Hyperplasia                          |    1              3                                      2           2   |      6  2.0|
      Vacuolization Cytoplasmic, Diffuse   |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1     |
      Fibrosis                             |                                                             2            |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |                4                    3                                    |      3  3.3|
      Pars Distalis, Cyst                  |                   X  X              X  X                 X           X  X|     14     |
      Pars Distalis, Hyperplasia           |                                     2                                    |      4  2.5|
      Pars Distalis, Pigmentation          |                3                                                         |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 3| 1| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 9| 3| 3| 3| 7| 8| 3| 3| 3|            |
                                           | 4| 0| 2| 2| 2| 9| 2| 2| 2| 2| 3| 3| 3| 3| 3| 8| 5| 2| 2| 2| 9| 1| 2| 2| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Nervosa, Hyperplasia            |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                X                                                         |      1     |
      C-Cell, Hyperplasia                  |       1                                               3     1  2         |      7  1.7|
      Follicle, Cyst                       |                                                                          |      1     |
      Follicular Cell, Hyperplasia         |                                                                         2|      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  M  +  +|  45        |
      Ectasia                              |    2     4     3                                               2        2|      6  2.8|
      Hyperplasia                          |                                                                         2|      3  2.3|
      Inflammation, Chronic                |                                                          2              2|      6  2.2|
      Inflammation, Suppurative            |    1     2              4                                   2            |      6  2.3|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                 3                        |      1  3.0|
      Cyst                                 |    X                       X                                             |      4     |
      Hemorrhage                           |                                                 3                        |      1  3.0|
      Inflammation, Chronic                |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hydrometra                           |                                                                          |      2  3.0|
      Hyperplasia, Cystic                  |                2     1                                                   |      4  1.8|
      Inflammation, Suppurative            |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                              +     +        +  +         |   7        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   2        |
      Anemia                               |                                                                          |      1  3.0|
      Leukocytosis                         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Reticulum Cell          |                   2              2                                       |      3  2.3|
      Myelofibrosis                        |                                                             2            |      1  2.0|
      Proliferation                        |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  I|  46        |
      Hyperplasia, Plasma Cell             |                                                             2            |      1  2.0|
      Lymphatic, Dilatation                | 2                                                                        |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 3| 1| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 9| 3| 3| 3| 7| 8| 3| 3| 3|            |
                                           | 4| 0| 2| 2| 2| 9| 2| 2| 2| 2| 3| 3| 3| 3| 3| 8| 5| 2| 2| 2| 9| 1| 2| 2| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Depletion Cellular                   |                                                             3            |      1  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  3.0|
      Fibrosis                             |                                                             2            |      1  2.0|
      Hematopoietic Cell Proliferation     |             2              2                                             |      6  2.7|
      Hyperplasia, Re Cell                 |             3                                                            |      1  3.0|
      Pigmentation, Hemosiderin            |                                                 3           2            |      3  2.7|
      Red Pulp, Atrophy                    |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +|  47        |
      Cyst                                 |                                                                          |      1     |
      Fibrosis                             |                                     2                                    |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  |    4  4  4  3  2  2  2  4  4  3  3  2  1  2     1  2  4  3     2     2  3|     43  2.7|
      Hyperplasia, Lobular                 |          3                          2        4        3                  |      8  2.9|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           | 4                                                                        |      1  4.0|
      Fibrosis                             | 4                                                                        |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Ulcer                                | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Hyperostosis                |          X        X     X                          X                     |      6     |
      Femur, Hyperostosis                  |          X        X                       X        X                     |      7     |
      Sternum, Hyperostosis                |                         X                                                |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |    X                          X                 X              X         |      7     |
      Hydrocephalus                        |                                                                2         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Chronic                |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Axon, White Matter, Degeneration     |    2                                                                     |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 3| 1| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 9| 3| 3| 3| 7| 8| 3| 3| 3|            |
                                           | 4| 0| 2| 2| 2| 9| 2| 2| 2| 2| 3| 3| 3| 3| 3| 8| 5| 2| 2| 2| 9| 1| 2| 2| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Gray Matter, Degeneration            |                      1                          1                        |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                 3                        |      2  2.5|
      Fibrosis                             |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |    1  1  1        1  1  1           1  1  1                       2  1  3|     26  1.2|
      Inflammation, Chronic                |                                                                         3|      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                   2                                                      |      2  2.5|
      Mediastinum, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                             4            |      1  4.0|
      Subpleura, Inflammation, Chronic     |                                                                          |            |
          Active                           |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Exudate                              |                                        X                       X         |      4     |
      Fungus                               |                                                                          |      1     |
      Inflammation, Chronic                |                                                       2                  |      2  2.0|
      Mucosa, Metaplasia, Squamous         |                                                       2                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cataract                             |       1  1  1  2  1  1                 1  1     1     1                  |     21  1.1|
      Retina, Atrophy                      | 2  2  3  3  2  3  3  3  2  3     3  3  2  1        3  2  3  1     3  3  3|     43  2.6|
      Sclera, Mineralization               |       1  1     1                       1                                 |      5  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |                                                                          |      1  2.0|
      Inflammation, Chronic                |                1                          1                             1|      3  1.0|
      Mineralization                       | 1  2  1  2  2     1  1  1  3  1     2     1  1  3  1  2  1  2  1  2  2  2|     43  1.7|
      Nephropathy                          | 1  1  1  1  1  1  1  1           1  1     2        1  1  1  1  2  1  1  1|     33  1.2|
      Renal Tubule, Cytoplasmic Alteration | 3                                                                        |      1  3.0|
      Renal Tubule, Degeneration           |                            3                          2                  |      2  2.5|
      Renal Tubule, Necrosis               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 2| 2| 7| 7| 7| 5| 5| 7| 7| 7| 1| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 6| 5| 7| 9| 3| 3| 5| 3| 3| 3| 2| 2| 3| 3| 3| 5| 3| 3| 3| 3|             
                                           | 9| 0| 0| 0| 0| 1| 2| 6| 5| 0| 1| 0| 0| 0| 0| 0| 1| 0| 0| 0| 9| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    400.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                        X           X  X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +     +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X  X  X  X     X  X     X        X  X  X  X  X  X  X  X        X  X   |             
      Clear Cell Focus                     |                                                                          |             
      Developmental Malformation           |                                     X              X                     |             
      Focal Cellular Change                |                            X                             X               |             
      Granuloma                            |          1                          4  3  2     1  2  1  3        3  2   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic                | 2           1                                         1                  |             
      Bile Duct, Hyperplasia               |    3  1                                      2     1     1     1        2|             
      Centrilobular, Atrophy               |    2           2        2                                                |             
      Hepatocyte, Hyperplasia, Nodular     |    2  2           2     2                    2                 2         |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
      Kupffer Cell, Pigmentation           |                         3                                               2|             
      Lobules, Necrosis                    |          1                    1     1                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                   +               |             
      Accessory Spleen                     |                                                                          |             
      Artery, Hypertrophy                  |                                                          4               |             
      Artery, Inflammation, Chronic Active |                                                          4               |             
      Fat, Inflammation, Granulomatous     |                      3                                                   |             
      Fat, Inflammation, Suppurative       |                      3                                                   |             
      Fat, Mineralization                  |                                                                          |             
      Fat, Necrosis                        |                      3                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                           1        1                     |             
      Hyperplasia, Nodular                 |          2                                2                          2   |             
      Inflammation, Chronic                |                                                    1           2         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                      2                                                   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 2| 2| 7| 7| 7| 5| 5| 7| 7| 7| 1| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 6| 5| 7| 9| 3| 3| 5| 3| 3| 3| 2| 2| 3| 3| 3| 5| 3| 3| 3| 3|             
                                           | 9| 0| 0| 0| 0| 1| 2| 6| 5| 0| 1| 0| 0| 0| 0| 0| 1| 0| 0| 0| 9| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    400.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |                                           2                              |             
      Inflammation, Chronic                |                                           2                              |             
      Ulcer                                |                   2                                                      |             
      Mucosa, Hyperplasia                  | 1                 2                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              | 2                             1                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       2     1           1  2        2  2           1     2     1  1     1|             
      Thrombosis                           |                         X                                                |             
      Epicardium, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                       2                  |             
      Myocardium, Inflammation, Chronic    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    | X                                                                 X      |             
      Angiectasis                          |                                        2                 3        2      |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     | X              X                    X                             X      |             
      Hemorrhage                           |                                              2              3            |             
      Hyperplasia                          |    1                          2                    2  2                  |             
      Necrosis                             | 3                    2                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         3                                                |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Pars Distalis, Angiectasis           | 2           2           3                             3                  |             
      Pars Distalis, Cyst                  | X     X                                            X  X                  |             
      Pars Distalis, Hyperplasia           | 2           2                                      2  1                  |             
      Pars Distalis, Pigmentation          |                                                                          |             
      Pars Intermedia, Cyst                |                                                    X                     |             
      Pars Intermedia, Hyperplasia         |                                                    2                     |             
      Pars Nervosa, Hyperplasia            |                                                       2                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                       X                  |             
      C-Cell, Hyperplasia                  |          1                          2                                   2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 2| 2| 7| 7| 7| 5| 5| 7| 7| 7| 1| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 6| 5| 7| 9| 3| 3| 5| 3| 3| 3| 2| 2| 3| 3| 3| 5| 3| 3| 3| 3|             
                                           | 9| 0| 0| 0| 0| 1| 2| 6| 5| 0| 1| 0| 0| 0| 0| 0| 1| 0| 0| 0| 9| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    400.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |          3                                         3              4     3|             
      Hyperplasia                          |                                              2        2        3        2|             
      Inflammation, Chronic                |       3                                               3                  |             
      Inflammation, Suppurative            |       3              3              2        4     3           4  4     2|             
      Metaplasia, Squamous                 |                      3                                                   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           X  X                       X  X|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                       3                  |             
      Cyst                                 |                                                       X                  |             
      Hemorrhage                           |             3                                                            |             
      Hydrometra                           |                         3                                                |             
      Hyperplasia, Cystic                  |       2     2                          3                                 |             
      Inflammation, Suppurative            |                                                                   4      |             
      Necrosis                             |             3                                                            |             
      Endometrium, Dysplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                         +                       M                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +                    +                                                |             
      Anemia                               |    3                    3                                                |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Reticulum Cell          |                                     3  2           1                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Lymphatic, Dilatation                |                                                                3         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                       2                  |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Re Cell                 |                                     4                                    |             
      Pigmentation, Hemosiderin            |                      4        3  3              3                        |             
      Lymphoid Follicle, Atrophy           |                                                                          |             
      Red Pulp, Atrophy                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 2| 2| 7| 7| 7| 5| 5| 7| 7| 7| 1| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 6| 5| 7| 9| 3| 3| 5| 3| 3| 3| 2| 2| 3| 3| 3| 5| 3| 3| 3| 3|             
                                           | 9| 0| 0| 0| 0| 1| 2| 6| 5| 0| 1| 0| 0| 0| 0| 0| 1| 0| 0| 0| 9| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    400.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 3  4  2     2     2  3  3  2              2  2  2  2     2     2  2  2  2|             
      Hyperplasia, Lobular                 |          1                                                               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Granulomatous                   |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hyperostosis                |                                                          X               |             
      Femur, Hyperostosis                  |                                                          X               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                      X                                                   |             
      Hemorrhage                           |                      3                                                   |             
      Hydrocephalus                        |                                                                          |             
      Inflammation, Chronic                |                                                       1                  |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                       1                  |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gray Matter, Degeneration            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                  4                          3            |             
      Infiltration Cellular, Histiocyte    |             1  1        1           1     1           1  1        1  1   |             
      Inflammation, Suppurative            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                      X  X                                                |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |          X                                                               |             
      Inflammation, Chronic                |          3                                                               |             
      Mucosa, Metaplasia, Squamous         |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 2| 2| 7| 7| 7| 5| 5| 7| 7| 7| 1| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 6| 5| 7| 9| 3| 3| 5| 3| 3| 3| 2| 2| 3| 3| 3| 5| 3| 3| 3| 3|             
                                           | 9| 0| 0| 0| 0| 1| 2| 6| 5| 0| 1| 0| 0| 0| 0| 0| 1| 0| 0| 0| 9| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    400.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |       3  2  2     1        1        1        4     1           1  1     1|             
      Cornea, Inflammation, Chronic        |                                                                          |             
      Cornea, Neovascularization           |                                                                          |             
      Retina, Atrophy                      | 1  3  3  2  3  2     3  3  3        2  3  3  1     3  3  2     3  3  3  3|             
      Sclera, Mineralization               |                                     1                          2         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                       2                  |             
      Hemorrhage                           |                                                 3                        |             
      Infarct                              |                                                       3                  |             
      Inflammation, Chronic                |                            1                                             |             
      Inflammation, Suppurative            |                         1                       3                        |             
      Mineralization                       | 2  2  2  1  2  1  2  1  1  2           2     1     3  2  2     3  1  2  1|             
      Nephropathy                          |    1  1  1  1        2  1  1           1  1           1  1        1  1  1|             
      Renal Tubule, Dilatation             |                                                 2                        |             
      Renal Tubule, Necrosis               |                                                 2                        |             
      Renal Tubule, Pigmentation           |                         2                    3                           |             
      Transitional Epithelium, Hyperplasia |                         1                                                |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                 3                        |             
      Inflammation, Suppurative            |                                                 3                        |             
      Mineralization                       |                      2                                                   |             
      Ulcer                                |                                                                          |             
      Mucosa, Hyperplasia                  |    1                                            3                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 7| 7| 7| 2| 7| 7| 7| 7| 5| 6| 5| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 5| 1| 3| 3| 7| 3| 3| 3| 3| 5| 1| 7| 5| 9| 8| 3| 3| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 8| 1| 1| 0| 0| 5| 1| 1| 1| 1| 4| 3| 0| 9| 2| 5| 1| 1| 1| 1| 8| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    400.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |          X                                            X                  |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                   X                                                      |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                            X                 X     X                 X  X|      5     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Erosion                              |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |          X  X     X  X  X  X     X  X     X  X  X  X  X  X  X  X  X  X  X|     36     |
      Clear Cell Focus                     |          X                 X                                   X         |      3     |
      Developmental Malformation           | X           X                       X                          X  X      |      7     |
      Focal Cellular Change                |                                                                          |      2     |
      Granuloma                            |          1  2           1  3  1  1                    2  3  1  1     1   |     21  1.9|
      Hematopoietic Cell Proliferation     |                                  1                                       |      1  1.0|
      Inflammation, Chronic                |                                                                          |      3  1.3|
      Bile Duct, Hyperplasia               |          1           1     1                    1              1         |     12  1.3|
      Centrilobular, Atrophy               |                                        2                                 |      4  2.0|
      Hepatocyte, Hyperplasia, Nodular     |                                        3                                 |      7  2.1|
      Hepatocyte, Vacuolization Cytoplasmic|                               2                                          |      1  2.0|
      Kupffer Cell, Pigmentation           |                                        2                                 |      3  2.3|
      Lobules, Necrosis                    |                                        2                                 |      4  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                             +           +  +               |   6        |
      Accessory Spleen                     |                                                       X                  |      1     |
      Artery, Hypertrophy                  |             2                                                            |      2  3.0|
      Artery, Inflammation, Chronic Active |             2                                                            |      2  3.0|
      Fat, Inflammation, Granulomatous     |                                                                          |      1  3.0|
      Fat, Inflammation, Suppurative       |                                                                          |      1  3.0|
      Fat, Mineralization                  |                                           4                              |      1  4.0|
      Fat, Necrosis                        |                                           4              3               |      3  3.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      2  1.0|
      Hyperplasia, Nodular                 |                   2                             2                        |      5  2.0|
      Inflammation, Chronic                |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 7| 7| 7| 2| 7| 7| 7| 7| 5| 6| 5| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 5| 1| 3| 3| 7| 3| 3| 3| 3| 5| 1| 7| 5| 9| 8| 3| 3| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 8| 1| 1| 0| 0| 5| 1| 1| 1| 1| 4| 3| 0| 9| 2| 5| 1| 1| 1| 1| 8| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    400.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Inflammation, Chronic                |                               2                                          |      2  2.0|
      Ulcer                                |                                                                          |      1  2.0|
      Mucosa, Hyperplasia                  |                               2                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                           2                              |      3  1.7|
      Inflammation, Granulomatous          |                                                                      1   |      1  1.0|
      Mineralization                       |                                        3                                 |      1  3.0|
      Ulcer                                |                                     3                                    |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |       2     1        1                             1     2  2        2  2|     19  1.5|
      Thrombosis                           |                                                                          |      1     |
      Epicardium, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
      Myocardium, Inflammation, Chronic    |                                                                         3|      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                           X                              |      3     |
      Angiectasis                          |          2                       3                    2        3     2   |      8  2.4|
      Basophilic Focus                     |                                     X                                    |      1     |
      Clear Cell Focus                     |                         X              X                    X        X   |      8     |
      Hemorrhage                           |                                                                          |      2  2.5|
      Hyperplasia                          |                                                                         2|      5  1.8|
      Necrosis                             |    3                                                                     |      3  2.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 7| 7| 7| 2| 7| 7| 7| 7| 5| 6| 5| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 5| 1| 3| 3| 7| 3| 3| 3| 3| 5| 1| 7| 5| 9| 8| 3| 3| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 8| 1| 1| 0| 0| 5| 1| 1| 1| 1| 4| 3| 0| 9| 2| 5| 1| 1| 1| 1| 8| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    400.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Angiectasis           |             2                                   4  2                 2   |      8  2.5|
      Pars Distalis, Cyst                  |                                  X  X  X  X  X                           |      9     |
      Pars Distalis, Hyperplasia           |             2           2        2     3        2           2            |     10  2.0|
      Pars Distalis, Pigmentation          |                                        2           2                     |      2  2.0|
      Pars Intermedia, Cyst                |                                                                          |      1     |
      Pars Intermedia, Hyperplasia         |                                                                          |      1  2.0|
      Pars Nervosa, Hyperplasia            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                                                          |      1     |
      C-Cell, Hyperplasia                  |                               1           1                 1  2         |      7  1.4|
      Follicular Cell, Hyperplasia         |                                  2                                       |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
      Ectasia                              |                               3                          3              3|      7  3.1|
      Hyperplasia                          |                               3                                   2     2|      7  2.3|
      Inflammation, Chronic                |                         2                                               2|      4  2.5|
      Inflammation, Suppurative            |                                                          4        3  3  2|     12  3.1|
      Metaplasia, Squamous                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                               X                       X                 X|      7     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      1     |
      Hemorrhage                           |                               4                                          |      2  3.5|
      Hydrometra                           |                                                                          |      1  3.0|
      Hyperplasia, Cystic                  |                               3                                          |      4  2.5|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  3.0|
      Endometrium, Dysplasia               |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |       +                       M                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   2        |
      Anemia                               |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 7| 7| 7| 2| 7| 7| 7| 7| 5| 6| 5| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 5| 1| 3| 3| 7| 3| 3| 3| 3| 5| 1| 7| 5| 9| 8| 3| 3| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 8| 1| 1| 0| 0| 5| 1| 1| 1| 1| 4| 3| 0| 9| 2| 5| 1| 1| 1| 1| 8| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    400.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Reticulum Cell          |                                                       2        2         |      5  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Hyperplasia, Plasma Cell|                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +|  47        |
      Hyperplasia, Plasma Cell             |                                        3                          3      |      2  3.0|
      Lymphatic, Dilatation                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                3                                                         |      2  2.5|
      Pigmentation                         |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                  2  2                       2     2      |      4  2.0|
      Hyperplasia, Re Cell                 |                                                                          |      1  4.0|
      Pigmentation, Hemosiderin            |                3                    2     4                              |      7  3.1|
      Lymphoid Follicle, Atrophy           |                                           3                              |      1  3.0|
      Red Pulp, Atrophy                    |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  +  +  +  +  +  +|  46        |
      Cyst                                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  |       3  2  2  2     1  2  3  2     1  3  3     3     2        2  2      |     32  2.3|
      Hyperplasia, Lobular                 |                                                 3                    3   |      3  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Granulomatous                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Hyperostosis                |                                                                          |      1     |
      Femur, Hyperostosis                  |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |       X                       X                                          |      3     |
      Hemorrhage                           |                                           1                              |      2  2.0|
      Hydrocephalus                        |                               2                                          |      1  2.0|
      Inflammation, Chronic                |                                                 2                        |      2  1.5|
      Vacuolization Cytoplasmic            |                                                 2                        |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 7| 7| 7| 2| 7| 7| 7| 7| 5| 6| 5| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 5| 1| 3| 3| 7| 3| 3| 3| 3| 5| 1| 7| 5| 9| 8| 3| 3| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 8| 1| 1| 0| 0| 5| 1| 1| 1| 1| 4| 3| 0| 9| 2| 5| 1| 1| 1| 1| 8| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    400.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Gray Matter, Degeneration            |                                                       1                  |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           | 3  3                                                                     |      4  3.3|
      Infiltration Cellular, Histiocyte    |          1                       1           1     1                    1|     14  1.0|
      Inflammation, Suppurative            |                                        2                                 |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                        3                    4            |      2  3.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Exudate                              |                      X     X  X        X                                 |      6     |
      Mucosa, Hyperplasia                  |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Exudate                              |                                                                          |      1     |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Mucosa, Metaplasia, Squamous         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cataract                             |       1  2  1     1     2  4              1        1  3  1  1  1  1     1|     25  1.6|
      Cornea, Inflammation, Chronic        |                            2                                             |      1  2.0|
      Cornea, Neovascularization           |                            2                                             |      1  2.0|
      Retina, Atrophy                      |       3  3  3     3  2  3  4  2  2     3  2     3  3  3  3  3  3  3  3  3|     40  2.7|
      Sclera, Mineralization               |                         2              1     1     1                     |      6  1.3|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Infarct                              |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                                     2                                    |      3  2.0|
      Mineralization                       |       2  1  2     2  1  2  2  2  1  2  1  2  1  2  2  1  1  1  2  2  1  2|     41  1.7|
      Nephropathy                          |       1  1  1     1  1  1  1  3  1  2  1  1     1  1  1  1     1  1  1  1|     34  1.1|
      Renal Tubule, Dilatation             |                2                                                         |      2  2.0|
      Renal Tubule, Necrosis               |                                                                          |      1  2.0|
      Renal Tubule, Pigmentation           |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 7| 7| 7| 2| 7| 7| 7| 7| 5| 6| 5| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 5| 1| 3| 3| 7| 3| 3| 3| 3| 5| 1| 7| 5| 9| 8| 3| 3| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 8| 1| 1| 0| 0| 5| 1| 1| 1| 1| 4| 3| 0| 9| 2| 5| 1| 1| 1| 1| 8| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    400.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Transitional Epithelium, Hyperplasia |                                     3                                    |      2  2.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                     +                                    |   1        |
      Calculus Micro Observation Only      |                                     X                                    |      1     |
      Inflammation, Suppurative            |                                     4                                    |      1  4.0|
      Mucosa, Hyperplasia                  |                                     4                                    |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  2.0|
      Ulcer                                |                                     4                                    |      1  4.0|
      Mucosa, Hyperplasia                  |                                     4                                    |      3  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 8| 2| 3| 3| 3| 3| 3| 3| 3| 9| 9| 1| 3| 3| 2| 9| 3| 3| 3| 1| 9| 3| 3| 3|             
                                           | 1| 3| 0| 0| 0| 0| 0| 0| 0| 0| 5| 7| 8| 0| 0| 8| 7| 0| 0| 0| 3| 6| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                                                +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                                                +         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    3           3                                               3         |             
      Basophilic Focus                     |    X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X     X  X     X|             
      Clear Cell Focus                     |                      X                    X                              |             
      Developmental Malformation           |                               X                          X              X|             
      Granuloma                            |    1     1     2  1                 2                          1         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic                |       1  2        2           1                 1                        |             
      Mixed Cell Focus                     |                                                                          |             
      Bile Duct, Hyperplasia               |          1  1           1  2           3           3     2  2        3   |             
      Centrilobular, Atrophy               |                                  2     2                    3        2   |             
      Hepatocyte, Hyperplasia, Nodular     |                3                 3     3                             2   |             
      Hepatocyte, Vacuolization Cytoplasmic|       2                                1                                 |             
      Kupffer Cell, Hyperplasia            |                                                                          |             
      Lobules, Necrosis                    |                2     1                                   2               |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +  +                                +  +                    +   |             
      Fat, Inflammation, Chronic           |          3                                                               |             
      Fat, Inflammation, Granulomatous     |          2  2                                                            |             
      Fat, Mineralization                  |             1                                3                       2   |             
      Fat, Necrosis                        |          3  3                                3  3                    4   |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                                +         |             
      Atrophy                              |                                                                2         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
      Mucosa, Dysplasia                    |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Erosion                              | 3                                                                        |             
      Mineralization                       |             2     2                                      3           3  2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |          2                 1              1  1     1              1      |             
      Myocardium, Inflammation, Chronic    |    2           1                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 8| 2| 3| 3| 3| 3| 3| 3| 3| 9| 9| 1| 3| 3| 2| 9| 3| 3| 3| 1| 9| 3| 3| 3|             
                                           | 1| 3| 0| 0| 0| 0| 0| 0| 0| 0| 5| 7| 8| 0| 0| 8| 7| 0| 0| 0| 3| 6| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Myocardium, Mineralization           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                            X                                            X|             
      Angiectasis                          |          3  2        2                             2     2               |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                X           X                       X  X     X            |             
      Cyst Multilocular                    |                                                                          |             
      Hyperplasia                          |                      3                                                   |             
      Vacuolization Cytoplasmic, Diffuse   |                      3           2                                       |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             1                    2                       1               |             
      Inflammation, Chronic                |          1                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                                                +         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |    X     X  X  X                 X                    X     X     X  X   |             
      Pars Distalis, Hyperplasia           |    1                             2                                2      |             
      Pars Distalis, Pigmentation          |                                                                          |             
      Pars Intermedia, Angiectasis         |                                                                          |             
      Pars Intermedia, Cyst                |                                                                      X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                                                                      +   |             
      C-Cell, Hyperplasia                  |                                                                      2   |             
      Follicle, Cyst                       |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                         1                                                |             
      Inflammation, Suppurative            |                                                       2                  |             
                                            __________________________________________________________________________|             
   Ovary                                   |                                                       +                  |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +                                +              +                       +|             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hydrometra                           |                                                                          |             
      Hyperplasia, Cystic                  |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 8| 2| 3| 3| 3| 3| 3| 3| 3| 9| 9| 1| 3| 3| 2| 9| 3| 3| 3| 1| 9| 3| 3| 3|             
                                           | 1| 3| 0| 0| 0| 0| 0| 0| 0| 0| 5| 7| 8| 0| 0| 8| 7| 0| 0| 0| 3| 6| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                  +     +                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Anemia                               |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +                                                            |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Fibrosis                             |                                                    3                     |             
      Hematopoietic Cell Proliferation     | 4                    2                          3              2        2|             
      Necrosis                             |                                                             4        3   |             
      Pigmentation, Hemosiderin            |       3                             3                          3         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  1  2  1  2     3  4  2  2  1  2  3  2  3  2  3  3  1  2  2  2  1  2  4|             
      Hyperplasia, Lobular                 |                   3        3     2     4                 4  4  2         |             
                                            __________________________________________________________________________|             
   Skin                                    |          +  +     +  +  +  +           +  +  +  +     +        +        +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Chronic                |                   1                                                      |             
      Nipple, Hypertrophy                  |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hyperostosis                |          X                       X                 X                     |             
      Femur, Hyperostosis                  |       X  X                                                           X   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |       X              X              X  X        X  X           X         |             
      Hydrocephalus                        |       2                                                                  |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                          1               |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Gray Matter, Degeneration            |                                                                   1      |             
      Parenchyma, White Matter,            |                                                                          |             
          Degeneration, Multifocal         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 8| 2| 3| 3| 3| 3| 3| 3| 3| 9| 9| 1| 3| 3| 2| 9| 3| 3| 3| 1| 9| 3| 3| 3|             
                                           | 1| 3| 0| 0| 0| 0| 0| 0| 0| 0| 5| 7| 8| 0| 0| 8| 7| 0| 0| 0| 3| 6| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                         1           1        2     3        1  1        2|             
      Inflammation, Chronic                |                                                          1               |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |          1  1        1           3     1                 1     1        1|             
      Hemorrhage                           |                                                                          |             
      Retina, Atrophy                      |       2  3  3     2  2  2        4  2  2     1  2  3  1  3  2  3  3  3  3|             
      Sclera, Mineralization               |          1              2                                      1         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 | X                                                           X            |             
      Hydronephrosis                       | 2                                                                        |             
      Infarct                              |                                                                      2   |             
      Inflammation, Chronic                | 1              2  2     1                                         1      |             
      Inflammation, Suppurative            |             1                                                            |             
      Mineralization                       | 2     2  2  1     1  1  1  2  2  2  1  1  2  2  1  2  1  1  1  2  1  3  2|             
      Nephropathy                          |    2  2  1  1  1     2  1  1     1  1  2        1  1  1     1  1  1  1  2|             
      Papilla, Necrosis                    |                                                                          |             
      Renal Tubule, Degeneration           |                      3                          3                    4   |             
      Transitional Epithelium, Hyperplasia |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 4| 6| 3| 3| 3| 5| 8| 3| 3| 3| 6| 8| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 1| 1| 1| 1| 2| 9| 1| 1| 1| 2| 4| 1| 1| 1| 8| 2| 1| 1| 1| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    200.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                 +                        |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                 +                        |   2        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |       2                                                                  |      4  2.8|
      Basophilic Focus                     | X  X  X  X  X  X     X  X  X  X  X  X  X  X        X  X  X  X  X  X  X  X|     43     |
      Clear Cell Focus                     |             X                 X                                          |      4     |
      Developmental Malformation           |                X  X                       X  X     X     X  X            |     10     |
      Granuloma                            |          3                       2  1                 1     3  4  3  3  2|     15  2.0|
      Hematopoietic Cell Proliferation     |                   1                                1                     |      2  1.0|
      Inflammation, Chronic                |    1                    1                                1     2         |      9  1.3|
      Mixed Cell Focus                     |                                                                      X   |      1     |
      Bile Duct, Hyperplasia               |    1           1        2  1        2  1  1     2     1                 1|     19  1.6|
      Centrilobular, Atrophy               |                                                 3                        |      5  2.4|
      Hepatocyte, Hyperplasia, Nodular     |                                     2                                    |      5  2.6|
      Hepatocyte, Vacuolization Cytoplasmic|                                              1  4                        |      4  2.0|
      Kupffer Cell, Hyperplasia            |                                              2                           |      1  2.0|
      Lobules, Necrosis                    |                   2                    1                       1         |      6  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
      Fat, Inflammation, Chronic           |                                                                          |      1  3.0|
      Fat, Inflammation, Granulomatous     |                                                                          |      2  2.0|
      Fat, Mineralization                  |                                                                          |      3  2.0|
      Fat, Necrosis                        |                                                                          |      5  3.2|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                   +                                                      |   2        |
      Atrophy                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                   2                                                      |      1  2.0|
      Mucosa, Dysplasia                    |          4                                                               |      1  4.0|
      Mucosa, Hyperplasia                  |          4        4                                                      |      2  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                     X                                    |      1     |
      Erosion                              |                                                                          |      1  3.0|
      Mineralization                       | 2                    1     2                                             |      8  2.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 4| 6| 3| 3| 3| 5| 8| 3| 3| 3| 6| 8| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 1| 1| 1| 1| 2| 9| 1| 1| 1| 2| 4| 1| 1| 1| 8| 2| 1| 1| 1| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    200.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    1           1        2  1     1  1     2                          1  2|     15  1.3|
      Myocardium, Inflammation, Chronic    |          1     1                    1                       1  1     1   |      8  1.1|
      Myocardium, Mineralization           |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |    X           X     X              X        X  X                        |      8     |
      Angiectasis                          |                               2  3                                       |      7  2.3|
      Basophilic Focus                     |             X                                                            |      1     |
      Clear Cell Focus                     |                   X                          X  X  X     X               |     10     |
      Cyst Multilocular                    |                                                                         X|      1     |
      Hyperplasia                          |       2                    3        2           3                        |      5  2.6|
      Vacuolization Cytoplasmic, Diffuse   |                               3                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |       1                                                                  |      4  1.3|
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                 +                        |   2        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |    3                                3  4                                3|      4  3.3|
      Pars Distalis, Cyst                  |                      X     X        X  X  X              X               |     15     |
      Pars Distalis, Hyperplasia           |                                                 2                        |      4  1.8|
      Pars Distalis, Pigmentation          |                                                 3                        |      1  3.0|
      Pars Intermedia, Angiectasis         |                                                 2                        |      1  2.0|
      Pars Intermedia, Cyst                |                                                 X                        |      2     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                               +     +                                +   |   4        |
      C-Cell, Hyperplasia                  |                                                                          |      1  2.0|
      Follicle, Cyst                       |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                               3                       2                  |      2  2.5|
      Hyperplasia                          |                                  2                                       |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 4| 6| 3| 3| 3| 5| 8| 3| 3| 3| 6| 8| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 1| 1| 1| 1| 2| 9| 1| 1| 1| 2| 4| 1| 1| 1| 8| 2| 1| 1| 1| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    200.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |          1                       2        1     2     3                  |      6  1.7|
      Inflammation, Suppurative            |                                  2                                       |      2  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |                      +  +                                                |   3        |
      Cyst                                 |                      X  X                                                |      2     |
                                            __________________________________________________________________________|____________|
   Uterus                                  |          +           +           +     +              +  +     +  +      |  12        |
      Cyst                                 |                                        X                 X        X      |      3     |
      Hemorrhage                           |          4                                                               |      1  4.0|
      Hydrometra                           |                      4                                                   |      1  4.0|
      Hyperplasia, Cystic                  |                      3                                                   |      1  3.0|
      Inflammation, Suppurative            |                                        4                                 |      1  4.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                              +  +                        |   4        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                    +                     |   1        |
      Anemia                               |                                                    X                     |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                   +           +                 +           +            |   5        |
      Hyperplasia, Reticulum Cell          |                                                 4                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                           2                              |      1  2.0|
      Fibrosis                             |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     | 2        2        3                          2     3                     |     10  2.5|
      Necrosis                             |                                                                          |      2  3.5|
      Pigmentation, Hemosiderin            |                3     2           3           3                           |      7  2.9|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  |    3  3  3  2  2  2  2  3     3  3     1  2  3  3  4  3  1  2  3  1     2|     45  2.3|
      Hyperplasia, Lobular                 |          3                                         3        2            |     10  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +        +  +  +  +  +  +  +     +  +  +  +     +  +            |  29        |
      Acanthosis                           |                                                    2                     |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Nipple, Hypertrophy                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Hyperostosis                |       X                                X              X                 X|      7     |
      Femur, Hyperostosis                  |                X                       X              X                 X|      7     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 4| 6| 3| 3| 3| 5| 8| 3| 3| 3| 6| 8| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 1| 1| 1| 1| 2| 9| 1| 1| 1| 2| 4| 1| 1| 1| 8| 2| 1| 1| 1| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    200.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |       X     X  X  X           X  X           X  X  X                     |     16     |
      Hydrocephalus                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                              1                           |      1  1.0|
      Gray Matter, Degeneration            |                                                                          |      1  1.0|
      Parenchyma, White Matter,            |                                                                          |            |
          Degeneration, Multifocal         |                                                 2                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                  3        2                              |      2  2.5|
      Infiltration Cellular, Histiocyte    |    1              3        1     1  1                          1        1|     14  1.4|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     | 3                                                                 2      |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cataract                             |          2           3  1     3     3  1                 1  1  2  1     2|     19  1.6|
      Hemorrhage                           |                                  2                                       |      1  2.0|
      Retina, Atrophy                      | 3  2  3  3  1  1     3  3  3  4     3  3  3  2  3  3  2  3  3  3  3  3  3|     42  2.6|
      Sclera, Mineralization               | 1                    1  2                          1  3  3     2  1      |     11  1.6|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                        1                                 |      1  1.0|
      Cyst                                 |                                                                          |      2     |
      Hydronephrosis                       |                   3                                                      |      2  2.5|
      Infarct                              |                                                                          |      1  2.0|
      Inflammation, Chronic                |       2                 2                                                |      7  1.6|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Mineralization                       | 2  2  2  2  2  1  1     1  3  2  2  1  1  2  1     2  2  2  2  2  1  2   |     45  1.6|
      Nephropathy                          | 1  2  3  1  1  1  1  1  3  1  1     1  1  1  2  1  1  2  1     1     1  1|     41  1.3|
      Papilla, Necrosis                    |                   3                                                      |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 4| 6| 3| 3| 3| 5| 8| 3| 3| 3| 6| 8| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 1| 1| 1| 1| 2| 9| 1| 1| 1| 2| 4| 1| 1| 1| 8| 2| 1| 1| 1| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    200.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Degeneration           |                                                                          |      3  3.3|
      Transitional Epithelium, Hyperplasia |                               1                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 1| 2| 3| 3|             
                                           | 1| 1| 1| 1| 2| 2| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 5| 0| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Parasite Metazoan                    |    X                             X     X                 X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X  X                                X                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                            X           X  X        X              X      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X     X  X  X  X  X     X  X  X  X     X  X  X     X     X  X  X|             
      Clear Cell Focus                     |       X  X           X     X     X  X     X        X                 X   |             
      Developmental Malformation           |             X  X        X              X                             X   |             
      Focal Cellular Change                |    X                                X  X        X                        |             
      Granuloma                            | 2  2  2  2  2     2     1  3     2     2           2              1      |             
      Hemorrhage                           |                                                 2                        |             
      Inflammation, Chronic                |                      2                                                   |             
      Inflammation, Chronic Active         |                                                                          |             
      Bile Duct, Cyst Multilocular         |                                                                          |             
      Bile Duct, Hyperplasia               | 2  2  2  2  2  2  3  1  2  3  3  3  2  2  3  2  1  2  2  4  2  2  1  2  2|             
      Centrilobular, Atrophy               |                               3                                          |             
      Hepatocyte, Hyperplasia, Nodular     |                                                          3               |             
      Hepatocyte, Vacuolization Cytoplasmic| 3  2           2           3        2  2        2           2           2|             
      Lobules, Necrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +  +     +        +           +  +|             
      Artery, Hypertrophy                  |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                         3|             
      Fat, Inflammation, Granulomatous     |                                        3                                 |             
      Fat, Mineralization                  |                                                 3        3           2   |             
      Fat, Necrosis                        |                                        3  2     3        4           4   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Atrophy                              |                         1  2  1     1     1                              |             
      Hyperplasia, Nodular                 |                                                                   1      |             
      Inflammation, Chronic                |                      1     1                                      1      |             
      Inflammation, Granulomatous          |                                                                         3|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 1| 2| 3| 3|             
                                           | 1| 1| 1| 1| 2| 2| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 5| 0| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Perforation                          |                                                                          |             
      Mucosa, Dysplasia                    |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion                              |                                                             3            |             
      Inflammation, Chronic Active         |    2                                                                     |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                2         |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3     2  3  2  3  2     1  2  2  1  2  2  3     3     3        2  2  2  2|             
      Thrombosis                           |                                                                          |             
      Epicardium, Inflammation, Chronic    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                   X                       X                 X            |             
      Angiectasis                          |                                  2                 3                     |             
      Basophilic Focus                     |                                                             X            |             
      Clear Cell Focus                     | X                       X                                                |             
      Hyperplasia                          |                      3                          3                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2                                               1      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia                          |                            4                                             |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |    2                                                                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                2                 2                                       |             
      Pars Distalis, Cyst                  |                                        X                                 |             
      Pars Distalis, Hyperplasia           |                            2     1                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         | 2  1  1  2        2  1  1              1                       1     1   |             
      C-Cell, Hyperplasia                  |    2                          1                 1  2  2              1   |             
      Follicle, Cyst                       |                X     X                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 1| 2| 3| 3|             
                                           | 1| 1| 1| 1| 2| 2| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 5| 0| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |       3                                                                  |             
      Inflammation, Chronic                |    3     3  2  2  2  2  2  3  2  3     2  2     2  2  2  3     3         |             
      Inflammation, Suppurative            |                                                                3         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Corpora Amylacea                     |                1                                                         |             
      Ectasia                              |                                                                          |             
      Fibrosis                             |                         2                                                |             
      Inflammation, Chronic                | 1              1              1                    1     2               |             
      Inflammation, Suppurative            | 2     1     1           2     2  2           3           3     2         |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 2           2  1  2              2  3     2     3     2                 1|             
      Spermatocele                         |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                                2         |             
      Seminiferous Tubule, Atrophy         |                                                                      4   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Anemia                               |                                                                          |             
      Leukocytosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                      4   |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mediastinal, Erythrophagocytosis     |                                                                   3      |             
      Mediastinal, Hemorrhage              |                         3                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythrophagocytosis                  |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Lymphatic, Dilatation                |                               4  3                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Pigmentation                         | 2  2  2  2  2        1  1  2     2  2  2  2  2  2     1  1  2  3  2  1   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |       3                                                                  |             
      Hematopoietic Cell Proliferation     |                2                                            2     3      |             
      Hyperplasia, Re Cell                 |       3                                                                  |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             X              X                                             |             
      Epithelial Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 1| 2| 3| 3|             
                                           | 1| 1| 1| 1| 2| 2| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 5| 0| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 1     4     1  1              2              2           2               |             
      Hyperplasia, Lobular                 |       2           3                                                      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Sebaceous Gland, Ectasia             |                                                                          |             
      Subcutaneous Tissue, Fibrosis        |          3                                                           3   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                X         |             
      Hydrocephalus                        |                                              2                 3         |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                     1                                    |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gray Matter, Degeneration            |                                                                          |             
      Gray Matter, Necrosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomatosis                         |                                                                          |             
      Congestion                           |                                                                          |             
      Foreign Body                         |                                                    1                     |             
      Hemorrhage                           |          2                                                               |             
      Infiltration Cellular, Histiocyte    |    1  1     1  1        1           1  1        1  1        1            |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                  1                                       |             
      Alveolar Epithelium, Hyperplasia     |                                           2                              |             
      Alveolus, Edema                      |                                                                          |             
      Artery, Mediastinum, Hypertrophy     |                                                                          |             
      Artery, Mediastinum, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              | X        X     X              X                                         X|             
      Foreign Body                         |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 1| 2| 3| 3|             
                                           | 1| 1| 1| 1| 2| 2| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 5| 0| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Fungus                               | X              X              X                                          |             
      Inflammation, Chronic                | 3        3                                                     2         |             
      Mucosa, Hyperplasia                  |                               3                                          |             
      Mucosa, Metaplasia, Squamous         |          2     2                                               2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |          1                 1        3                             4      |             
      Cornea, Mineralization               |                                        1                                 |             
      Retina, Atrophy                      | 2        2  1        2  3  1  3  2  3  2  3           2  2        3      |             
      Sclera, Mineralization               |                         3        1                 1  2  2     2         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          X               |             
      Inflammation, Chronic                | 2  2  3  2  2  2  1     1        1  2              2  1        1     1   |             
      Inflammation, Suppurative            |             1  1                                                     1   |             
      Mineralization                       |          1           1           1        1                              |             
      Nephropathy                          | 2  2  3  2  3  2  2  1  2  2  2  1  2  1  2  2  1  1  1  1  2  2  1  1  1|             
      Capsule, Fibrosis                    |                                                                      2   |             
      Renal Tubule, Cytoplasmic Alteration |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 7| 0| 3| 3| 3| 0| 3| 3| 3| 3| 8| 9| 3| 3| 3| 2| 3| 3| 3| 3| 0| 9| 3| 3| 3|            |
                                           | 9| 0| 2| 2| 3| 7| 2| 3| 3| 3| 8| 3| 2| 3| 3| 6| 2| 3| 3| 3| 8| 6| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                               X                                          |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |             X                                                           X|      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                      X  X                                X           X   |      9     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |       X  X  X     X  X  X  X           X  X     X  X  X  X     X  X  X  X|     37     |
      Clear Cell Focus                     |          X                                X        X  X  X           X   |     15     |
      Developmental Malformation           |                                                                      X  X|      7     |
      Focal Cellular Change                |                                                                          |      4     |
      Granuloma                            |       1           1  2     1        1     1     1        1        2  2  4|     23  1.7|
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                1         |      2  1.5|
      Inflammation, Chronic Active         |          3                    2  1                                       |      3  2.0|
      Bile Duct, Cyst Multilocular         |                                                 X                        |      1     |
      Bile Duct, Hyperplasia               | 1  1  2     2  1  2  3  3  2  2  1  1  3     1  1  1  1  1  2  2     1  1|     47  1.9|
      Centrilobular, Atrophy               |                         2                                                |      2  2.5|
      Hepatocyte, Hyperplasia, Nodular     |                         2              2                                 |      3  2.3|
      Hepatocyte, Vacuolization Cytoplasmic|                      2        3           2     2     2     3            |     15  2.3|
      Lobules, Necrosis                    |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +        +        +           +  +           +  +           +  +     +|  16        |
      Artery, Hypertrophy                  |                                                                   3     2|      2  2.5|
      Artery, Inflammation, Chronic Active |                                                                   3     2|      3  2.7|
      Fat, Inflammation, Granulomatous     |                      3                             3                     |      3  3.0|
      Fat, Mineralization                  |             2        4           3              3              3         |      8  2.9|
      Fat, Necrosis                        |             4        4           4  1           4  4           3         |     12  3.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |             1  1                       1        2                       1|     10  1.2|
      Hyperplasia, Nodular                 |       2                                   3           3  2           2   |      6  2.2|
      Inflammation, Chronic                |             1                                                            |      4  1.0|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 7| 0| 3| 3| 3| 0| 3| 3| 3| 3| 8| 9| 3| 3| 3| 2| 3| 3| 3| 3| 0| 9| 3| 3| 3|            |
                                           | 9| 0| 2| 2| 3| 7| 2| 3| 3| 3| 8| 3| 2| 3| 3| 6| 2| 3| 3| 3| 8| 6| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                               3                                          |      1  3.0|
      Inflammation, Chronic                |                                                                      3   |      1  3.0|
      Perforation                          |                               X                                          |      1     |
      Mucosa, Dysplasia                    |                                                                      3   |      1  3.0|
      Mucosa, Hyperplasia                  |                               4                                      3   |      2  3.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                               4                                          |      1  4.0|
      Erosion                              |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Mineralization                       |                      2                                                   |      1  2.0|
      Ulcer                                |    3                                                                     |      2  2.5|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                  +                                       |   1        |
      Hyperkeratosis                       |                                  2                                       |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |       2  2  3     1  2  1  3  2  1        3  3  2  2     1  2  2  2  1   |     37  2.1|
      Thrombosis                           |                   X                                X                     |      2     |
      Epicardium, Inflammation, Chronic    |                                  3                                       |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                         X                                                |      4     |
      Angiectasis                          |                                                       2  2        3      |      5  2.4|
      Basophilic Focus                     |                                                          X               |      2     |
      Clear Cell Focus                     |    X                                         X  X              X  X      |      7     |
      Hyperplasia                          |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |             3                    2                                       |      3  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |                                           3                             3|      4  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 7| 0| 3| 3| 3| 0| 3| 3| 3| 3| 8| 9| 3| 3| 3| 2| 3| 3| 3| 3| 0| 9| 3| 3| 3|            |
                                           | 9| 0| 2| 2| 3| 7| 2| 3| 3| 3| 8| 3| 2| 3| 3| 6| 2| 3| 3| 3| 8| 6| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |                                                                   1     2|      4  1.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pigmentation                         |             1        1     1              1              1  2  1  1      |     18  1.2|
      C-Cell, Hyperplasia                  |                                                       1                  |      7  1.4|
      Follicle, Cyst                       |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                                          |      1  3.0|
      Inflammation, Chronic                |       2  2  3  2     3  3  2     2  2        2     2  2  3  2  3  2  3  2|     35  2.3|
      Inflammation, Suppurative            |             2           3                                            2   |      4  2.5|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Corpora Amylacea                     |       2                                                                  |      2  1.5|
      Ectasia                              |                                                                         3|      1  3.0|
      Fibrosis                             |                                                    1           2        3|      4  2.0|
      Inflammation, Chronic                |          1                    1     2           1                       2|     10  1.3|
      Inflammation, Suppurative            | 1     2  2  1  2              3     3        1  2  2           2         |     20  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |    2     3  2  1           2  3  1  2  2     2     2     1        1  3   |     24  2.0|
      Spermatocele                         |                               X                                          |      1     |
      Interstitial Cell, Hyperplasia       |                                                                          |      1  2.0|
      Seminiferous Tubule, Atrophy         |                               4                                          |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                         +                                                |   1        |
      Anemia                               |                         X                                                |      1     |
      Leukocytosis                         |                         X                                                |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  4.0|
      Hyperplasia, Reticulum Cell          |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Hyperplasia, Lymphoid      |                3                                                         |      1  3.0|
      Mediastinal, Erythrophagocytosis     |                                                    3                     |      2  3.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 7| 0| 3| 3| 3| 0| 3| 3| 3| 3| 8| 9| 3| 3| 3| 2| 3| 3| 3| 3| 0| 9| 3| 3| 3|            |
                                           | 9| 0| 2| 2| 3| 7| 2| 3| 3| 3| 8| 3| 2| 3| 3| 6| 2| 3| 3| 3| 8| 6| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
      Erythrophagocytosis                  |                                                                3         |      1  3.0|
      Hyperplasia, Plasma Cell             |                3              3                                   2      |      3  2.7|
      Lymphatic, Dilatation                |                3           3           3                                 |      5  3.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                    2                     |      1  2.0|
      Pigmentation                         | 3        1  1     1     1  1     2  2     2  2  1     3  2  3  1  2  1  1|     38  1.7|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                         2                                                |      2  2.5|
      Hematopoietic Cell Proliferation     |    3                                         2                       2   |      6  2.3|
      Hyperplasia, Re Cell                 |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                                                                          |      2     |
      Epithelial Cell, Hyperplasia         |             3                                                            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  47        |
      Hyperplasia, Cystic                  |             1        1  1  3  4     4     1     2              2         |     16  2.0|
      Hyperplasia, Lobular                 |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |          X                                                               |      1     |
      Fibrosis                             | 4              3                                                         |      2  3.5|
      Hemorrhage                           |                4                                                         |      1  4.0|
      Inflammation, Suppurative            | 4                                                                        |      1  4.0|
      Sebaceous Gland, Ectasia             |                      3                                                   |      1  3.0|
      Subcutaneous Tissue, Fibrosis        |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                  +                                       |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                               X                                          |      2     |
      Hydrocephalus                        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 7| 0| 3| 3| 3| 0| 3| 3| 3| 3| 8| 9| 3| 3| 3| 2| 3| 3| 3| 3| 0| 9| 3| 3| 3|            |
                                           | 9| 0| 2| 2| 3| 7| 2| 3| 3| 3| 8| 3| 2| 3| 3| 6| 2| 3| 3| 3| 8| 6| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Gray Matter, Degeneration            |                                                                         1|      1  1.0|
      Gray Matter, Necrosis                |       1                                                                  |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenomatosis                         |             3                                                            |      1  3.0|
      Congestion                           |                               3                                          |      1  3.0|
      Foreign Body                         |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |       1                       1        1              1  1        2  1  1|     18  1.1|
      Inflammation, Chronic                |       1                                                                  |      1  1.0|
      Mineralization                       |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                      2   |      2  2.0|
      Alveolus, Edema                      |                               2                                          |      1  2.0|
      Artery, Mediastinum, Hypertrophy     |             3                                                            |      1  3.0|
      Artery, Mediastinum, Inflammation,   |                                                                          |            |
           Chronic Active                  |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Exudate                              | X           X  X                       X     X  X        X     X  X      |     14     |
      Foreign Body                         |                                                                          |      1  2.0|
      Fungus                               | X              X                       X     X  X              X  X      |     10     |
      Inflammation, Chronic                |                2                       2     2                    3      |      7  2.4|
      Mucosa, Hyperplasia                  |                2                                2                        |      3  2.3|
      Mucosa, Metaplasia, Squamous         |                2                                                  3      |      5  2.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                             M            |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cataract                             |          3              2              2                       3  1      |      9  2.2|
      Cornea, Mineralization               |                                                                          |      1  1.0|
      Retina, Atrophy                      |       1  3  2  1  2  3  3  3     1  1  2  3  2     2           3  2  1   |     31  2.1|
      Sclera, Mineralization               |    2  2  3  2  2  2  2  2  2     1  2  2  1     2  1  1           3  2  1|     25  1.8|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1     |
      Inflammation, Chronic                |    2  2  2  2     2        2        2        3     2  1  3     2  2  2  2|     29  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 7| 0| 3| 3| 3| 0| 3| 3| 3| 3| 8| 9| 3| 3| 3| 2| 3| 3| 3| 3| 0| 9| 3| 3| 3|            |
                                           | 9| 0| 2| 2| 3| 7| 2| 3| 3| 3| 8| 3| 2| 3| 3| 6| 2| 3| 3| 3| 8| 6| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |       1  1        1                    1     1                 1         |      9  1.0|
      Mineralization                       |          1  1                       1                             1      |      8  1.0|
      Nephropathy                          | 1  2  2  2  2  1  3  1  2  2  3  1  2  2  2  2  1  2  2  2  1  3  2  2  2|     50  1.8|
      Capsule, Fibrosis                    |                                                                          |      1  2.0|
      Renal Tubule, Cytoplasmic Alteration |                                  3                                       |      1  3.0|
      Renal Tubule, Hyperplasia            |                            1                                             |      1  1.0|
      Transitional Epithelium, Hyperplasia |       1                                                                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 5| 7| 7| 7| 3| 5| 7| 7| 7| 4| 5| 6| 6| 6| 5| 5| 7| 7| 7| 4| 6| 7| 2| 7|             
                             DAY ON TEST   | 9| 5| 2| 2| 2| 8| 5| 2| 2| 2| 2| 0| 0| 8| 8| 7| 9| 1| 1| 2| 9| 2| 2| 0| 2|             
                                           | 9| 8| 9| 9| 9| 8| 8| 9| 9| 9| 7| 6| 5| 0| 0| 3| 3| 5| 8| 9| 9| 6| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    400.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  M  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                4         |             
      Inflammation, Suppurative            |                                                                3         |             
      Parasite Metazoan                    |                                              X                          X|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  M  +     +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                          2        1      |             
      Basophilic Focus                     |       X  X           X  X  X                       X  X  X        X     X|             
      Clear Cell Focus                     |       X     X                                                            |             
      Congestion                           |                                                    2                     |             
      Degeneration, Cystic                 |                                                                          |             
      Developmental Malformation           |          X  X  X  X                       X                              |             
      Focal Cellular Change                |                         X                                         X      |             
      Granuloma                            |                                                                          |             
      Hematopoietic Cell Proliferation     |                   1           2                 2                        |             
      Inflammation, Chronic                |                                                       1                  |             
      Inflammation, Chronic Active         |                                           1                              |             
      Bile Duct, Hyperplasia               |    2  2  2  2  2  1  2  3  2     2  2  3  1           2  2  3  3  2     1|             
      Centrilobular, Atrophy               |    2                          2                    2           2         |             
      Centrilobular, Necrosis              |                               2                                          |             
      Hepatocyte, Hyperplasia, Nodular     |    2                                                                    2|             
      Hepatocyte, Vacuolization Cytoplasmic|                4                                                         |             
      Kupffer Cell, Hyperplasia            |                                                                          |             
      Lobules, Necrosis                    |                         1                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +  +  +  +     +  +  +  +                    +     +        +      |             
      Accessory Spleen                     |                                                                          |             
      Artery, Hypertrophy                  |                                                                   2      |             
      Artery, Inflammation, Chronic Active |             2        2     2                                      3      |             
      Fat, Inflammation, Granulomatous     |                         4                                3               |             
      Fat, Mineralization                  |          3                 3  2                    3     3               |             
      Fat, Necrosis                        |       4  4     3        3  3  4                    4     3               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       3              4                             2                     |             
      Basophilic Focus                     |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 5| 7| 7| 7| 3| 5| 7| 7| 7| 4| 5| 6| 6| 6| 5| 5| 7| 7| 7| 4| 6| 7| 2| 7|             
                             DAY ON TEST   | 9| 5| 2| 2| 2| 8| 5| 2| 2| 2| 2| 0| 0| 8| 8| 7| 9| 1| 1| 2| 9| 2| 2| 0| 2|             
                                           | 9| 8| 9| 9| 9| 8| 8| 9| 9| 9| 7| 6| 5| 0| 0| 3| 3| 5| 8| 9| 9| 6| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    400.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Nodular                 |       2     3        3  2                       3        2               |             
      Inflammation, Chronic                |                      4                                                   |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                           3                              |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                          |             
      Mucosa, Hyperplasia                  |                                           3                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                          |             
      Mucosa, Dysplasia                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Fibrosis                      |                                                                          |             
      Aorta, Hemorrhage                    |                                                                          |             
      Aorta, Inflammation, Chronic         |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1     2  2  2     2  2  3     2     2  2     2  1  2  3  1  1  1  3     3|             
      Thrombosis                           |                                                                          |             
      Epicardium, Fibrosis                 |                                                                          |             
      Epicardium, Inflammation, Chronic    |                                                                          |             
      Myocardium, Inflammation, Chronic    |             3        2                                         3         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |       X                 X                       X                        |             
      Angiectasis                          |                                                                          |             
      Clear Cell Focus                     |                         X                       X                        |             
      Cyst                                 |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          |                                     1                                    |             
      Necrosis                             |                                                                      2   |             
      Vacuolization Cytoplasmic, Diffuse   |    3                                               3        3            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 5| 7| 7| 7| 3| 5| 7| 7| 7| 4| 5| 6| 6| 6| 5| 5| 7| 7| 7| 4| 6| 7| 2| 7|             
                             DAY ON TEST   | 9| 5| 2| 2| 2| 8| 5| 2| 2| 2| 2| 0| 0| 8| 8| 7| 9| 1| 1| 2| 9| 2| 2| 0| 2|             
                                           | 9| 8| 9| 9| 9| 8| 8| 9| 9| 9| 7| 6| 5| 0| 0| 3| 3| 5| 8| 9| 9| 6| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    400.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                X         |             
      Pars Distalis, Hyperplasia           |                                        1                       2  1      |             
      Pars Intermedia, Cyst                |                                                                          |             
      Pars Nervosa, Hyperplasia            |                                                             2            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |                      2                 1                 1     1  2      |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |    1              1                       1                              |             
      Follicle, Cyst                       |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                     +                                    |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                 4     2                 3|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |    2     2  3        2     2     2     3  2        2  2  3  2  2  2     2|             
      Inflammation, Suppurative            |             2                                                            |             
      Mineralization                       |          2                                                               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Corpora Amylacea                     |                                                                          |             
      Inflammation, Chronic                |                                                                   1     1|             
      Inflammation, Suppurative            |                         3        2                             1         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                            2              2  3                 2  2      |             
      Interstitial Cell, Hyperplasia       |                                  2                          2            |             
      Seminiferous Tubule, Atrophy         |                                              4     4     4               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
      Myelofibrosis                        |                                                                2         |             
      Proliferation                        |                   3                             3                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 5| 7| 7| 7| 3| 5| 7| 7| 7| 4| 5| 6| 6| 6| 5| 5| 7| 7| 7| 4| 6| 7| 2| 7|             
                             DAY ON TEST   | 9| 5| 2| 2| 2| 8| 5| 2| 2| 2| 2| 0| 0| 8| 8| 7| 9| 1| 1| 2| 9| 2| 2| 0| 2|             
                                           | 9| 8| 9| 9| 9| 8| 8| 9| 9| 9| 7| 6| 5| 0| 0| 3| 3| 5| 8| 9| 9| 6| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    400.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                                           3     3                        |             
      Lymphatic, Dilatation                |             3                    2              3                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                     2                                    |             
      Infiltration Cellular, Mast Cell     |                                                                          |             
      Pigmentation                         | 1  2  1  1  1        2  2  1        3        1  1        2  1  1         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                   3           4                 4                        |             
      Necrosis                             |    3                                                                     |             
      Pigmentation, Hemosiderin            | 3                                                                        |             
      Lymphoid Follicle, Atrophy           | 2                                                                        |             
      Red Pulp, Atrophy                    |                                                                      2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +|             
      Hyperplasia, Cystic                  |          2                                                              2|             
      Hyperplasia, Lobular                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |       X                                                                  |             
      Inflammation, Suppurative            |                         2                                                |             
      Mineralization                       |                         4  2                                             |             
      Ulcer                                |    3                                            4                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                            +                    +                        |             
      Hemorrhage                           |                                                 4                        |             
      Inflammation, Chronic                |                                                 4                        |             
      Mineralization                       |                            2                                             |             
      Necrosis                             |                                                 4                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                       X                  |             
      Corpora Amylacea                     |                                                                          |             
      Hemorrhage                           |                                                       3                  |             
      Inflammation, Chronic                |                                                                2         |             
      Necrosis                             |                                                                2         |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | M  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 5| 7| 7| 7| 3| 5| 7| 7| 7| 4| 5| 6| 6| 6| 5| 5| 7| 7| 7| 4| 6| 7| 2| 7|             
                             DAY ON TEST   | 9| 5| 2| 2| 2| 8| 5| 2| 2| 2| 2| 0| 0| 8| 8| 7| 9| 1| 1| 2| 9| 2| 2| 0| 2|             
                                           | 9| 8| 9| 9| 9| 8| 8| 9| 9| 9| 7| 6| 5| 0| 0| 3| 3| 5| 8| 9| 9| 6| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    400.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gray Matter, Degeneration            |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomatosis                         |                                                                          |             
      Congestion                           | 4              3                    3                                4   |             
      Infiltration Cellular, Histiocyte    |                   1     1                       4        1        1      |             
      Inflammation, Chronic                |             1                                                     2      |             
      Leukocytosis                         |                               2                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                       3                  |             
      Alveolus, Edema                      | 3                                                                    3   |             
      Artery, Mediastinum, Hypertrophy     |                                                                          |             
      Artery, Mediastinum, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                  X  X           X  X           X  X      |             
      Foreign Body                         |                                     2           2                        |             
      Fungus                               |                                                 X              X         |             
      Inflammation, Chronic                |                                                 2              2  2      |             
      Mucosa, Hyperplasia                  |                                                 2                 3      |             
      Mucosa, Metaplasia, Squamous         |                                                                2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |    +                                                                     |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  M  +  +  +  +  I  +  +  A  +  +  +  +  +  +  +  +  +|             
      Cataract                             |          2  2           2  1              1              1               |             
      Retina, Atrophy                      |    2  3  2  3     2     3  3     1     3  3     1  3  2  3  1  2  2     3|             
      Sclera, Mineralization               |             1              2     3     2           2  1  1  1  2        1|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                    2                     |             
      Infarct                              |             2     2                                            2         |             
      Inflammation, Chronic                |       4  2  4        2  2  3     2  2     3     2  3     3     2  4     4|             
      Inflammation, Suppurative            |       1     1                             1                       1      |             
      Mineralization                       |                                     1           1                        |             
      Nephropathy                          |    1  3  2  3  2  1  2  2  2  2  3  2  2  3  1  2  2  1  3  3  3  3     3|             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Necrosis               |                                                                3         |             
      Renal Tubule, Pigmentation           |                                                 2                        |             
      Transitional Epithelium, Hyperplasia |       2                                                                 3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 5| 7| 7| 7| 3| 5| 7| 7| 7| 4| 5| 6| 6| 6| 5| 5| 7| 7| 7| 4| 6| 7| 2| 7|             
                             DAY ON TEST   | 9| 5| 2| 2| 2| 8| 5| 2| 2| 2| 2| 0| 0| 8| 8| 7| 9| 1| 1| 2| 9| 2| 2| 0| 2|             
                                           | 9| 8| 9| 9| 9| 8| 8| 9| 9| 9| 7| 6| 5| 0| 0| 3| 3| 5| 8| 9| 9| 6| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    400.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 3| 3| 4| 5| 7| 1| 3| 7| 7| 7|            |
                             DAY ON TEST   | 6| 0| 2| 2| 2| 8| 9| 1| 2| 2| 1| 2| 2| 2| 2| 7| 7| 4| 5| 3| 5| 7| 1| 3| 3|            |
                                           | 4| 5| 9| 9| 9| 5| 7| 8| 9| 9| 2| 9| 9| 9| 9| 3| 5| 6| 8| 0| 4| 3| 2| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    400.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
      Edema                                |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Parasite Metazoan                    |                   X                                                      |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Inflammation, Granulomatous          |       1                                                                  |      1  1.0|
      Parasite Metazoan                    |                   X                                                  X  X|      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  45        |
      Parasite Metazoan                    |             X  X                                                     X   |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  M  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                            3                                         2   |      4  2.0|
      Basophilic Focus                     |       X     X        X  X        X  X  X                 X           X  X|     20     |
      Clear Cell Focus                     |                                     X     X              X               |      5     |
      Congestion                           |                                                                          |      1  2.0|
      Degeneration, Cystic                 |             2                                                            |      1  2.0|
      Developmental Malformation           |                      X                                                   |      6     |
      Focal Cellular Change                |                            X        X                                    |      4     |
      Granuloma                            |                                     1                                    |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      3  1.7|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               | 1           1     2  3  2  3     2  2  3  3  2  1  2  1  2        2  2  3|     37  2.1|
      Centrilobular, Atrophy               |                                                                          |      4  2.0|
      Centrilobular, Necrosis              |                               4                                   3      |      3  3.0|
      Hepatocyte, Hyperplasia, Nodular     |                      2     2                                            2|      5  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|       2                                                                  |      2  3.0|
      Kupffer Cell, Hyperplasia            |                                                                   2      |      1  2.0|
      Lobules, Necrosis                    |                                              3                           |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +           +              +  +        +  +  +           +   |  19        |
      Accessory Spleen                     |                                           X                              |      1     |
      Artery, Hypertrophy                  |             3                          3                                 |      3  2.7|
      Artery, Inflammation, Chronic Active |             3                          3                                 |      6  2.5|
      Fat, Inflammation, Granulomatous     |                                                          3               |      3  3.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 3| 3| 4| 5| 7| 1| 3| 7| 7| 7|            |
                             DAY ON TEST   | 6| 0| 2| 2| 2| 8| 9| 1| 2| 2| 1| 2| 2| 2| 2| 7| 7| 4| 5| 3| 5| 7| 1| 3| 3|            |
                                           | 4| 5| 9| 9| 9| 5| 7| 8| 9| 9| 2| 9| 9| 9| 9| 3| 5| 6| 8| 0| 4| 3| 2| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    400.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Fat, Mineralization                  |                         2                          3     2           3   |      9  2.7|
      Fat, Necrosis                        |                         2                          3     4           3   |     12  3.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Atrophy                              |       1                                                              2   |      5  2.4|
      Basophilic Focus                     |                                                                         X|      2     |
      Hyperplasia, Nodular                 |    3                       3           3                       2     3  3|     12  2.7|
      Inflammation, Chronic                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                           +                              |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                     2                                    |      1  2.0|
      Inflammation, Suppurative            |    4                                                                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      1  3.0|
      Inflammation, Chronic                |    3                                                                     |      1  3.0|
      Mineralization                       |                                                    1                     |      1  1.0|
      Ulcer                                |    4                                                                     |      1  4.0|
      Mucosa, Hyperplasia                  |    4                                               1                     |      3  2.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                               3                    3  3                  |      3  3.0|
      Hyperplasia, Lymphoid                |                                     3                                    |      1  3.0|
      Inflammation, Chronic Active         |       2                                                                  |      1  2.0|
      Mineralization                       |                      3                             3                 3   |      3  3.0|
      Ulcer                                |    3                                                           2         |      2  2.5|
      Mucosa, Dysplasia                    |                                     3                                    |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                       +                  |   1        |
      Aorta, Fibrosis                      |                                                       3                  |      1  3.0|
      Aorta, Hemorrhage                    |                                                       2                  |      1  2.0|
      Aorta, Inflammation, Chronic         |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    3  2  1  3  2  3  2  2     1  3  1  3  2  3  1  1  2  3        2  2  3|     40  2.1|
      Thrombosis                           |                                                                   X      |      1     |
      Epicardium, Fibrosis                 |                                                       2                  |      1  2.0|
      Epicardium, Inflammation, Chronic    |                                                       3                  |      1  3.0|
      Myocardium, Inflammation, Chronic    |                   1                                   2                  |      5  2.2|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 3| 3| 4| 5| 7| 1| 3| 7| 7| 7|            |
                             DAY ON TEST   | 6| 0| 2| 2| 2| 8| 9| 1| 2| 2| 1| 2| 2| 2| 2| 7| 7| 4| 5| 3| 5| 7| 1| 3| 3|            |
                                           | 4| 5| 9| 9| 9| 5| 7| 8| 9| 9| 2| 9| 9| 9| 9| 3| 5| 6| 8| 0| 4| 3| 2| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    400.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |          X  X                 X                       X              X   |      8     |
      Angiectasis                          |    4                                                                     |      1  4.0|
      Clear Cell Focus                     |                   X                    X              X           X     X|      7     |
      Cyst                                 |                                  X                                       |      1     |
      Fibrosis                             |    3                                                                     |      1  3.0|
      Hyperplasia                          |    2                                                                 2   |      3  1.7|
      Necrosis                             |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Diffuse   |    3                                                                     |      4  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|  49        |
      Hyperplasia                          |             1                          1  2                              |      3  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Cyst                  |                      X                                                   |      2     |
      Pars Distalis, Hyperplasia           |          1           2                             2  2              2   |      8  1.6|
      Pars Intermedia, Cyst                |                      X                                                   |      1     |
      Pars Nervosa, Hyperplasia            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pigmentation                         | 1                    1  1  2                                            1|     10  1.3|
      Ultimobranchial Cyst                 |                                                                         X|      1     |
      C-Cell, Hyperplasia                  |                                                       2                  |      4  1.3|
      Follicle, Cyst                       |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                      3     2                                             |      5  2.8|
      Hyperplasia                          |                         3                                                |      1  3.0|
      Inflammation, Chronic                |    2  2  3  2                    2     2              2  2     2     4   |     25  2.2|
      Inflammation, Suppurative            | 2                       4  3                          2           2      |      6  2.5|
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Corpora Amylacea                     |                                           2                              |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 3| 3| 4| 5| 7| 1| 3| 7| 7| 7|            |
                             DAY ON TEST   | 6| 0| 2| 2| 2| 8| 9| 1| 2| 2| 1| 2| 2| 2| 2| 7| 7| 4| 5| 3| 5| 7| 1| 3| 3|            |
                                           | 4| 5| 9| 9| 9| 5| 7| 8| 9| 9| 2| 9| 9| 9| 9| 3| 5| 6| 8| 0| 4| 3| 2| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    400.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |    3              2                                               1      |      5  1.6|
      Inflammation, Suppurative            |                   2                    2                          2      |      6  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +              +                                                      |   2        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |                      2     2     3  3  1                       1         |     11  2.1|
      Interstitial Cell, Hyperplasia       |                                                                          |      2  2.0|
      Seminiferous Tubule, Atrophy         |                               3     4        2        2                  |      7  3.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                  3                                       |      1  3.0|
      Hyperplasia, Reticulum Cell          |          2                                                               |      1  2.0|
      Myelofibrosis                        |                                                                          |      1  2.0|
      Proliferation                        |                   2                                                      |      3  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Hyperplasia, Plasma Cell|                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +     +  +  +  +|  46        |
      Hyperplasia, Plasma Cell             |                            2                                      3     2|      5  2.6|
      Lymphatic, Dilatation                |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  48        |
      Hemorrhage                           |                               2                       2                  |      3  2.0|
      Infiltration Cellular, Mast Cell     |                                                       3                  |      1  3.0|
      Pigmentation                         |       2  2        3     2     3  1  2  2        1  1  3                 2|     26  1.7|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                            3     3  1                                    |      3  2.3|
      Hematopoietic Cell Proliferation     |                   2           2  2                                       |      6  2.8|
      Necrosis                             |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            | 3                                                                        |      2  3.0|
      Lymphoid Follicle, Atrophy           | 2                                                                        |      2  2.0|
      Red Pulp, Atrophy                    | 2                                3  2                                    |      4  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  M|  44        |
      Hyperplasia, Cystic                  |       2  1        2  2                                            2      |      7  1.9|
      Hyperplasia, Lobular                 |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                       X                  |      2     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 3| 3| 4| 5| 7| 1| 3| 7| 7| 7|            |
                             DAY ON TEST   | 6| 0| 2| 2| 2| 8| 9| 1| 2| 2| 1| 2| 2| 2| 2| 7| 7| 4| 5| 3| 5| 7| 1| 3| 3|            |
                                           | 4| 5| 9| 9| 9| 5| 7| 8| 9| 9| 2| 9| 9| 9| 9| 3| 5| 6| 8| 0| 4| 3| 2| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    400.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                       3                  |      2  2.5|
      Mineralization                       |                                                                          |      2  3.0|
      Ulcer                                |                                                                          |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                            +                                             |   3        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      1     |
      Corpora Amylacea                     |                                                                         2|      1  2.0|
      Hemorrhage                           |                                                                         1|      2  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Gray Matter, Degeneration            |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenomatosis                         |          3                                                               |      1  3.0|
      Congestion                           | 3                                                  2        4  2         |      8  3.1|
      Infiltration Cellular, Histiocyte    |                                  1                    3  1           1   |      9  1.6|
      Inflammation, Chronic                |                                                                          |      2  1.5|
      Leukocytosis                         |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |       2                          1     2                                 |      4  2.0|
      Alveolus, Edema                      | 2                                                                        |      3  2.7|
      Artery, Mediastinum, Hypertrophy     |          2                                                               |      1  2.0|
      Artery, Mediastinum, Inflammation,   |                                                                          |            |
           Chronic Active                  |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Exudate                              |                            X                                         X   |      8     |
      Foreign Body                         |                            2                                             |      3  2.0|
      Fungus                               |                                                                          |      2     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 3| 3| 4| 5| 7| 1| 3| 7| 7| 7|            |
                             DAY ON TEST   | 6| 0| 2| 2| 2| 8| 9| 1| 2| 2| 1| 2| 2| 2| 2| 7| 7| 4| 5| 3| 5| 7| 1| 3| 3|            |
                                           | 4| 5| 9| 9| 9| 5| 7| 8| 9| 9| 2| 9| 9| 9| 9| 3| 5| 6| 8| 0| 4| 3| 2| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    400.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                            2                                             |      4  2.0|
      Mucosa, Hyperplasia                  |                                                                          |      2  2.5|
      Mucosa, Metaplasia, Squamous         |                            2                                             |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|  45        |
      Cataract                             |          2                 2        1     2                              |     10  1.6|
      Retina, Atrophy                      |       3  3  3  2  3  3  3  3     3  3  3  3           1  3        3  3  3|     35  2.6|
      Sclera, Mineralization               |       3     2     1     2        2  2     3              2           2  2|     20  1.9|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                   +      |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydronephrosis                       |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      3  2.0|
      Inflammation, Chronic                |    3  2  2  3  2  3  2  4  4     4  4  3  4              4        4  4  4|     32  3.1|
      Inflammation, Suppurative            |          1              1  1     1  1     1              1           1  1|     13  1.0|
      Mineralization                       |       1  1  1  1        2                          1  3              1   |     10  1.3|
      Nephropathy                          |    4  2  2  3  2  2  3  3  3  1  3  3  2  3     1     3  3     2  4  3  3|     44  2.4|
      Renal Tubule, Hyperplasia            |                   2                                                      |      1  2.0|
      Renal Tubule, Necrosis               |                               2                                          |      2  2.5|
      Renal Tubule, Pigmentation           |                      3                                2                  |      3  2.3|
      Transitional Epithelium, Hyperplasia |                   2     2                                2               |      5  2.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 9| 2| 2| 2| 6| 7| 1| 2| 2| 6| 5| 2| 2| 2| 3| 2| 2| 2| 2| 8| 1| 2| 2| 2|             
                                           | 8| 7| 9| 9| 9| 1| 6| 9| 8| 9| 4| 2| 9| 9| 9| 5| 9| 9| 9| 9| 2| 0| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                      2        2                                          |             
      Inflammation, Suppurative            |                               2                                          |             
      Parasite Metazoan                    |                            X                          X                 X|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                    X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                         2                                                |             
      Parasite Metazoan                    |                                     X           X                        |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       3                                            1                     |             
      Basophilic Focus                     |    X  X     X        X     X     X     X  X     X  X  X  X        X  X  X|             
      Clear Cell Focus                     |             X        X                 X              X  X              X|             
      Congestion                           |                                                                          |             
      Degeneration, Cystic                 |                                                 2  1                     |             
      Developmental Malformation           | X           X                                            X  X            |             
      Eosinophilic Focus                   |                                                                          |             
      Granuloma                            |                                  1  2     3              1        2  2  2|             
      Hematopoietic Cell Proliferation     |    2     2        2  3  3                                                |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                          2               |             
      Bile Duct, Cyst Multilocular         |                                                                   X      |             
      Bile Duct, Hyperplasia               | 1  2  3  2  2  2     2  2  3  2  3  2  2  3     3  2  2  3  1     2  1  2|             
      Centrilobular, Atrophy               |                                                                          |             
      Centrilobular, Necrosis              |    1              2     2                                                |             
      Hepatocyte, Hyperplasia, Nodular     |                2                                                         |             
      Hepatocyte, Vacuolization Cytoplasmic|       2           3  2           2           2              2     3  2   |             
      Kupffer Cell, Hyperplasia            | 2                             3                                          |             
      Kupffer Cell, Pigmentation           |                                                                3         |             
      Lobules, Necrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    M  +        +  +           +                 +  +     +        +     +|             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Artery, Mineralization               |                                                                          |             
      Fat, Inflammation, Granulomatous     |       2        2                                2  2                     |             
      Fat, Mineralization                  |       2        3              2                 3  2                     |             
      Fat, Necrosis                        |       4        4              4                 3  4                     |             
      Fat, Pigmentation                    |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 9| 2| 2| 2| 6| 7| 1| 2| 2| 6| 5| 2| 2| 2| 3| 2| 2| 2| 2| 8| 1| 2| 2| 2|             
                                           | 8| 7| 9| 9| 9| 1| 6| 9| 8| 9| 4| 2| 9| 9| 9| 5| 9| 9| 9| 9| 2| 0| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                   2                             3  2  1  1  1            |             
      Hyperplasia, Nodular                 |                                           3              2               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |          4                       2           2                           |             
      Inflammation, Chronic                |                                     2                                    |             
      Mineralization                       |                                                                          |             
      Ulcer                                |          4                                                               |             
      Mucosa, Hyperplasia                  |          3                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |          3                                                               |             
      Erosion                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       | 4                       3  3                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3  2  2  2  3     2  2  2  2  3  3  3  3           3  3  2  1  3     3  1|             
      Thrombosis                           |    X                    X     X                                          |             
      Myocardium, Inflammation, Chronic    | 3                                                                        |             
      Myocardium, Mineralization           | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                      X  X                 X                              |             
      Angiectasis                          |             2                                         2     2        2   |             
      Clear Cell Focus                     |          X                                X                 X            |             
      Hematopoietic Cell Proliferation     |    2              3  3  2                                                |             
      Hyperplasia                          | 4                    2                                   2        2      |             
      Vacuolization Cytoplasmic, Diffuse   | 3                                                                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2  1                                                   |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |       2                                                                  |             
      Pars Distalis, Cyst                  |                                                    X              X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 9| 2| 2| 2| 6| 7| 1| 2| 2| 6| 5| 2| 2| 2| 3| 2| 2| 2| 2| 8| 1| 2| 2| 2|             
                                           | 8| 7| 9| 9| 9| 1| 6| 9| 8| 9| 4| 2| 9| 9| 9| 5| 9| 9| 9| 9| 2| 0| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Hyperplasia           |    2  2     1     3              3     1                    3            |             
      Pars Intermedia, Angiectasis         |                                                          3               |             
      Pars Intermedia, Cyst                |                                                    X                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Concretion                           |                                                                      2   |             
      Mineralization                       | 2                                                                        |             
      Pigmentation                         |       1     1     1              1  1  2  1        1  1  1        1      |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |       3                       2  1     2              2  1           2  2|             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                          3               |             
      Pigmentation                         |                                                          2               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |    4                                   2                                 |             
      Hyperplasia                          |    3                                                                     |             
      Inflammation, Chronic                |          2        2  2  2  2        2  2  2        3  3           2      |             
      Inflammation, Suppurative            |                      2                 2              2           2      |             
      Metaplasia, Squamous                 |    4                    2                                                |             
      Necrosis                             |    3                                                                     |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Corpora Amylacea                     |                         2                                                |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic                |    2     2              2  1                    1     1  1              2|             
      Inflammation, Suppurative            |    2     3     2           3  2                 2     1     1  2        2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 2     1           3        3  3        2  3     2  2  2  3  2  1     1   |             
      Seminiferous Tubule, Atrophy         | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Depletion Cellular                   |                                                                          |             
      Proliferation                        | 2  3              3     3     3              2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 9| 2| 2| 2| 6| 7| 1| 2| 2| 6| 5| 2| 2| 2| 3| 2| 2| 2| 2| 8| 1| 2| 2| 2|             
                                           | 8| 7| 9| 9| 9| 1| 6| 9| 8| 9| 4| 2| 9| 9| 9| 5| 9| 9| 9| 9| 2| 0| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Erythrophagocytosis     |                                                                   3      |             
      Mediastinal, Hemorrhage              |                               3                                          |             
      Mediastinal, Hyperplasia, Reticulum  |                                                                          |             
          Cell                             |                               3                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Mast Cell                       |                               3                                          |             
      Mediastinal, Pigmentation            |                3  3                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |                                                                          |             
      Erythrophagocytosis                  |                   2                                                      |             
      Hemorrhage                           |                               2                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                      3                                                   |             
      Hyperplasia, Reticulum Cell          |                               3                                          |             
      Lymphatic, Dilatation                | 3                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |                                                                          |             
      Erythrophagocytosis                  |                                                             2            |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Mast Cell     |                3                                                         |             
      Pigmentation                         | 1     2     2  1  1  3  2  1     3     3  2     1     2  1  3     3  2  2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                             1            |             
      Fibrosis                             |                                                                         3|             
      Hematopoietic Cell Proliferation     | 2  3              4  3  4  2  3     2        3                           |             
      Hyperplasia, Re Cell                 |                                                                          |             
      Pigmentation, Hemosiderin            | 2        3     3                                            3            |             
      Lymphoid Follicle, Atrophy           | 3                                                                        |             
      Red Pulp, Atrophy                    |                                                                      2  3|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  M  M  M  +  M  M  +  M  +  M  M  M  +  M  +  M  +  M  +  +  M  M|             
      Epithelial Cell, Hyperplasia         |                                                    2     2               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia, Cystic                  |          4           2  2  3        1                          3         |             
      Hyperplasia, Lobular                 |                            2                                             |             
      Inflammation, Granulomatous          |                                                                   2      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Cyst Epithelial Inclusion            |                                     X              X                     |             
      Cyst Multilocular                    |                                                                          |             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 9| 2| 2| 2| 6| 7| 1| 2| 2| 6| 5| 2| 2| 2| 3| 2| 2| 2| 2| 8| 1| 2| 2| 2|             
                                           | 8| 7| 9| 9| 9| 1| 6| 9| 8| 9| 4| 2| 9| 9| 9| 5| 9| 9| 9| 9| 2| 0| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Hair Follicle, Atrophy               |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
      Subcutaneous Tissue, Granuloma       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hyperostosis                | 3                                                                        |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                   +  +                          +                        |             
      Edema                                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |          X     2                                                         |             
      Developmental Malformation           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                2                                                         |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mast Cell     |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Axon, Hypertrophy                    |    3                                                                     |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gray Matter, Cytoplasmic Alteration  |                                        2                                 |             
      Gray Matter, Degeneration            |       1                                                                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomatosis                         |       2                                                                  |             
      Congestion                           |                         2                                                |             
      Foreign Body                         |          2                                                               |             
      Infiltration Cellular, Histiocyte    |          2                 1              1           1  1  1        2   |             
      Inflammation, Chronic                |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                           1           2                  |             
      Alveolus, Edema                      |                                                                          |             
      Lymphatic, Dilatation                |                                                    3                     |             
      Mediastinum, Edema                   |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              | X                                                     X              X  X|             
      Foreign Body                         |                                                                          |             
      Fungus                               | X                                                                    X   |             
      Inflammation, Chronic                |                                                                      3   |             
      Mucosa, Hyperplasia                  |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 9| 2| 2| 2| 6| 7| 1| 2| 2| 6| 5| 2| 2| 2| 3| 2| 2| 2| 2| 8| 1| 2| 2| 2|             
                                           | 8| 7| 9| 9| 9| 1| 6| 9| 8| 9| 4| 2| 9| 9| 9| 5| 9| 9| 9| 9| 2| 0| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mucosa, Metaplasia, Squamous         | 2                                                                    2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2                                                                        |             
      Mineralization                       | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |    3                                                                     |             
      Hemorrhage                           | 3                                                                        |             
      Cornea, Inflammation, Chronic        | 2                                                                        |             
      Retina, Atrophy                      |    2  3  1  1        1     1        1     3        2        2        3  2|             
      Sclera, Mineralization               |          2           2  3  1        1  2        1  2     3     1     2  2|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                  3                                       |             
      Fibrosis                             |                         2                                                |             
      Glomerulosclerosis                   |                         2                                                |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Chronic                |       2  2  2              1     2  3  3  3           2  2        3  2  2|             
      Inflammation, Suppurative            |                                     1           1  1  1           1  1   |             
      Mineralization                       | 4                 1     2     2     1                       1            |             
      Nephropathy                          | 3  1  2  3  2  2  1  2  1  2  2  3  3  2  3     3  3  2  2  2  1  3  3  2|             
      Renal Tubule, Degeneration           |                                                                          |             
      Renal Tubule, Pigmentation           |                2  3                                                      |             
      Venule, Infiltration Cellular,       |                                                                          |             
          Histiocyte                       |                                                             2            |             
      Venule, Pigmentation                 |                                                             2            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 1| 2| 2| 2| 9| 2| 2| 2| 2| 1| 0| 2| 3| 3| 1| 3| 1| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 8| 4| 9| 9| 9| 5| 9| 9| 9| 9| 7| 8| 2| 0| 0| 4| 2| 1| 0| 0| 2| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    200.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Edema                                |                                                                          |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Parasite Metazoan                    |                            X                                             |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                               X                       X                  |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |                                                                          |      1  2.0|
      Parasite Metazoan                    |             X     X     X                                      X        X|      7     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |    2              2                                                      |      4  2.0|
      Basophilic Focus                     |       X  X  X        X     X        X  X     X     X  X  X  X  X  X  X  X|     31     |
      Clear Cell Focus                     |          X                                X              X  X           X|     11     |
      Congestion                           |                                  3                 3                     |      2  3.0|
      Degeneration, Cystic                 |                                                                          |      2  1.5|
      Developmental Malformation           |                                     X                    X               |      6     |
      Eosinophilic Focus                   |             X                                                            |      1     |
      Granuloma                            |          1                 1              1                          1  2|     12  1.6|
      Hematopoietic Cell Proliferation     |                3                                                         |      6  2.5|
      Hemorrhage                           | 3                                                                        |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Bile Duct, Cyst Multilocular         |                                                                          |      1     |
      Bile Duct, Hyperplasia               | 2     3  2  2  2  2  3  4  2  1     3  1  2  1  3  2  2  2  1  2  2  2  3|     45  2.1|
      Centrilobular, Atrophy               |                                     2                                    |      1  2.0|
      Centrilobular, Necrosis              |                1                                                         |      4  1.5|
      Hepatocyte, Hyperplasia, Nodular     |                         3                       2                        |      3  2.3|
      Hepatocyte, Vacuolization Cytoplasmic|    3              2                       2     2        2              3|     14  2.3|
      Kupffer Cell, Hyperplasia            | 2                                            2                           |      4  2.3|
      Kupffer Cell, Pigmentation           |    3                                                                     |      2  3.0|
      Lobules, Necrosis                    | 2  2                             3                                       |      3  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +  +        +  +     +     +  +     +     +        +        +  +     +|  22        |
      Artery, Inflammation, Chronic Active |                   2                                                      |      1  2.0|
      Artery, Mineralization               |                                              3                           |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 1| 2| 2| 2| 9| 2| 2| 2| 2| 1| 0| 2| 3| 3| 1| 3| 1| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 8| 4| 9| 9| 9| 5| 9| 9| 9| 9| 7| 8| 2| 0| 0| 4| 2| 1| 0| 0| 2| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    200.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Fat, Inflammation, Granulomatous     |       2                       3        3              4        3        2|     10  2.5|
      Fat, Mineralization                  |    3           2        3        3     2              3        2        3|     13  2.5|
      Fat, Necrosis                        |    4  3        4        4     4  4     3              4        4        4|     15  3.8|
      Fat, Pigmentation                    |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                1                                                     1  2|      9  1.6|
      Hyperplasia, Nodular                 |                      2     2                                   3        3|      6  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          2                             2                                 |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      3  2.7|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Mineralization                       |                                           4  3                           |      2  3.5|
      Ulcer                                |                                  4        4                              |      3  4.0|
      Mucosa, Hyperplasia                  |                                  3        4                              |      3  3.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  3.0|
      Erosion                              |    2                                               2                     |      2  2.0|
      Inflammation, Chronic                |                               3                                      3   |      2  3.0|
      Mineralization                       |                                           3  4                 3         |      6  3.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                              +                           |   1        |
      Aorta, Mineralization                |                                              4                           |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 3  3  2     3  2  2  2  2  2  2  3     2  2  2  3     3  1  3  1  2  3  2|     42  2.3|
      Thrombosis                           | X                                                                        |      4     |
      Myocardium, Inflammation, Chronic    |                                                                         1|      2  2.0|
      Myocardium, Mineralization           |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                     X  X  X     X           X     X     X|     10     |
      Angiectasis                          |                   2                                3                     |      6  2.2|
      Clear Cell Focus                     |             X              X              X                              |      6     |
      Hematopoietic Cell Proliferation     |                                                                          |      4  2.5|
      Hyperplasia                          |    4  2                    1        2                    2               |      9  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 1| 2| 2| 2| 9| 2| 2| 2| 2| 1| 0| 2| 3| 3| 1| 3| 1| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 8| 4| 9| 9| 9| 5| 9| 9| 9| 9| 7| 8| 2| 0| 0| 4| 2| 1| 0| 0| 2| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    200.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Vacuolization Cytoplasmic, Diffuse   |    4                                3        2  3           3            |      6  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2           2     2        1                                             |      6  1.7|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  | X                    X     X                                X            |      6     |
      Pars Distalis, Hyperplasia           | 3                       1                                2               |     10  2.1|
      Pars Intermedia, Angiectasis         |                                                                          |      1  3.0|
      Pars Intermedia, Cyst                |                         X                                                |      2     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Concretion                           |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Pigmentation                         | 2        1        1        1        1           1        1              1|     19  1.1|
      Ultimobranchial Cyst                 |                                                                         X|      1     |
      C-Cell, Hyperplasia                  |                         2  3           3        1  1     2              2|     15  1.9|
      Follicle, Cyst                       |                               X                                X         |      2     |
      Follicular Cell, Hyperplasia         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              | +                                                                        |   1        |
      Hemorrhage                           | 2                                                                        |      1  2.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                   3                 2                                    |      4  2.8|
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Chronic                |       2     2        2     2  2     2  2  3        2  2  2  2        2  2|     25  2.1|
      Inflammation, Suppurative            |          4           2     1                          1              2   |      9  2.0|
      Metaplasia, Squamous                 |                                                                          |      2  3.0|
      Necrosis                             |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 1| 2| 2| 2| 9| 2| 2| 2| 2| 1| 0| 2| 3| 3| 1| 3| 1| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 8| 4| 9| 9| 9| 5| 9| 9| 9| 9| 7| 8| 2| 0| 0| 4| 2| 1| 0| 0| 2| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    200.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Corpora Amylacea                     |    2     2                    2        2        2                        |      6  2.0|
      Fibrosis                             |          3              2              2              2                  |      4  2.3|
      Inflammation, Chronic                | 2        2        2     2        3  1  1        1  1  2        1     3  1|     21  1.6|
      Inflammation, Suppurative            | 2  2     3  2  1  2  2     2  2  3  2  3           3  2  1     2        1|     27  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +                                         +                           |   2        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                      3     1     1  1     1                 2     3  2  1|     23  2.0|
      Seminiferous Tubule, Atrophy         | 1  4  4                             3  2     4                           |      7  3.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                   3      |      1  3.0|
      Depletion Cellular                   |    3                                                                     |      1  3.0|
      Proliferation                        |                2                             3                 3         |      9  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Erythrophagocytosis     |                                                                          |      1  3.0|
      Mediastinal, Hemorrhage              |                                                             4            |      2  3.5|
      Mediastinal, Hyperplasia, Reticulum  |                                                                          |            |
          Cell                             |                                                                          |      1  3.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Mast Cell                       |                                                                          |      1  3.0|
      Mediastinal, Pigmentation            |                                                                   3      |      3  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +|  48        |
      Depletion Cellular                   | 3                                                                        |      1  3.0|
      Erythrophagocytosis                  |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                    3                     |      1  3.0|
      Hyperplasia, Plasma Cell             |                                                    2                     |      2  2.5|
      Hyperplasia, Reticulum Cell          |                                                                          |      1  3.0|
      Lymphatic, Dilatation                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Depletion Cellular                   | 3                                                                        |      1  3.0|
      Erythrophagocytosis                  | 3                                                                        |      2  2.5|
      Hemorrhage                           |                                                             4            |      1  4.0|
      Infiltration Cellular, Mast Cell     |                               3                                          |      2  3.0|
      Pigmentation                         | 1           2     2     2  2  1     1        1  2     2  2  3  2  2     2|     33  1.9|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 1| 2| 2| 2| 9| 2| 2| 2| 2| 1| 0| 2| 3| 3| 1| 3| 1| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 8| 4| 9| 9| 9| 5| 9| 9| 9| 9| 7| 8| 2| 0| 0| 4| 2| 1| 0| 0| 2| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    200.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis                             |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                4                       2                                 |     11  2.9|
      Hyperplasia, Re Cell                 |                                           4                              |      1  4.0|
      Pigmentation, Hemosiderin            |    3                                                                     |      5  2.8|
      Lymphoid Follicle, Atrophy           | 2                                                                        |      2  2.5|
      Red Pulp, Atrophy                    | 2                                                                        |      3  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +|  30        |
      Epithelial Cell, Hyperplasia         |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Cystic                  |    2     4           1  2        2  3  2     4                 2     1   |     16  2.4|
      Hyperplasia, Lobular                 |       2        1                 3     2                                 |      5  2.0|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  49        |
      Acanthosis                           |                                                    2                     |      1  2.0|
      Cyst Epithelial Inclusion            |             X     X              X  X                                    |      6     |
      Cyst Multilocular                    |             X                                                            |      1     |
      Foreign Body                         |             3                                                            |      1  3.0|
      Inflammation, Chronic                |                                                    2                     |      1  2.0|
      Inflammation, Granulomatous          |             4                                                            |      1  4.0|
      Inflammation, Suppurative            |                                                 4                        |      1  4.0|
      Hair Follicle, Atrophy               |                                                    3                     |      1  3.0|
      Subcutaneous Tissue, Edema           | 3                                                                        |      1  3.0|
      Subcutaneous Tissue, Granuloma       |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Hyperostosis                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +                                                                        |   4        |
      Edema                                | 3                                                                        |      1  3.0|
      Inflammation, Chronic Active         | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      2  2.0|
      Developmental Malformation           |                            X                                             |      1     |
      Hemorrhage                           |                               4                 1                        |      2  2.5|
      Hydrocephalus                        |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 1| 2| 2| 2| 9| 2| 2| 2| 2| 1| 0| 2| 3| 3| 1| 3| 1| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 8| 4| 9| 9| 9| 5| 9| 9| 9| 9| 7| 8| 2| 0| 0| 4| 2| 1| 0| 0| 2| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    200.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Mast Cell     |                                                    3                     |      1  3.0|
      Inflammation, Chronic                |                                                                   3      |      1  3.0|
      Axon, Hypertrophy                    |                                                    1                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Gray Matter, Cytoplasmic Alteration  |                                                                          |      1  2.0|
      Gray Matter, Degeneration            |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenomatosis                         |                                                                          |      1  2.0|
      Congestion                           |    3                                               3        3            |      4  2.8|
      Foreign Body                         |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |    4     1     1  1           2                 2                    1   |     14  1.5|
      Inflammation, Chronic                |          1                                                               |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                               2                                          |      3  1.7|
      Alveolus, Edema                      |    4                                                                     |      1  4.0|
      Lymphatic, Dilatation                |                                                                          |      1  3.0|
      Mediastinum, Edema                   | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Exudate                              |          X  X                       X        X           X               |      9     |
      Foreign Body                         |             2                                3           2               |      3  2.3|
      Fungus                               |             X                                X                           |      4     |
      Inflammation, Chronic                |             3                                            3               |      3  3.0|
      Mucosa, Hyperplasia                  |                                              3                           |      2  3.0|
      Mucosa, Metaplasia, Squamous         |             2                       3        2                           |      5  2.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |             2                                                            |      2  2.0|
      Mineralization                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cataract                             |                         1           1                                    |      3  1.7|
      Hemorrhage                           |                                                                          |      1  3.0|
      Cornea, Inflammation, Chronic        |                                                                          |      1  2.0|
      Retina, Atrophy                      | 2     1  2  1     3  1  1  2        3     3  2  2        1     1  1  2   |     28  1.8|
      Sclera, Mineralization               |    2  1  3           2     1        2     2     1  1     1     2  3  2  1|     26  1.8|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 1| 2| 2| 2| 9| 2| 2| 2| 2| 1| 0| 2| 3| 3| 1| 3| 1| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 8| 4| 9| 9| 9| 5| 9| 9| 9| 9| 7| 8| 2| 0| 0| 4| 2| 1| 0| 0| 2| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    200.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Glomerulosclerosis                   |                                                                          |      1  2.0|
      Hydronephrosis                       |                                              4                           |      1  4.0|
      Inflammation, Chronic                |          2  2     3  3     3  2  2  2  2  3  2        3  3     1  2  3  2|     30  2.3|
      Inflammation, Suppurative            |                   2  1     1              1           1  1           2   |     13  1.2|
      Mineralization                       | 3     1                    1           1     3        1  1     1     1   |     15  1.6|
      Nephropathy                          | 2  4  3  3  3  1  3  3  1  3  2  2  3  3  3  4  2  2  3  3  3  1  2  3  2|     49  2.4|
      Renal Tubule, Degeneration           |                         4                                                |      1  4.0|
      Renal Tubule, Pigmentation           |                                                                          |      2  2.5|
      Venule, Infiltration Cellular,       |                                                                          |            |
          Histiocyte                       |                                                                          |      1  2.0|
      Venule, Pigmentation                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           

--multipart-boundary
Content-type: text/plain
Range: bytes 608694-608694/608694


--multipart-boundary--