National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3136

TDMS Study 05006-05 Pathology Tables

NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97
Route: GAVAGE                                                                                                     Time: 09:26:06




       Facility:  Southern Research Institute

       Chemical CAS #:  000100527

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 7| 1| 3| 3| 1| 3| 3| 3| 3| 2| 9| 3| 3| 3| 6| 3| 3| 3| 3| 7| 0| 3| 3| 3|             
                                           | 2| 4| 1| 2| 2| 5| 1| 1| 1| 2| 0| 8| 1| 1| 2| 4| 2| 2| 2| 2| 4| 1| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                              X                           |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X     X  X  X  X     X     X  X     X  X  X  X|             
      Clear Cell Focus                     |                                                                          |             
      Developmental Malformation           |       X                                                                  |             
      Focal Cellular Change                |                                                                          |             
      Granuloma                            |       1        3     2                    2                       1  2   |             
      Hematopoietic Cell Proliferation     | 1                                2                                       |             
      Inflammation, Chronic                | 2     2                             1                                    |             
      Mixed Cell Focus                     |                                                             X            |             
      Bile Duct, Cyst Multilocular         |             X                                                            |             
      Bile Duct, Hyperplasia               | 1  1     1  1     1     1        1     1           2           1         |             
      Centrilobular, Atrophy               |                                                                          |             
      Hepatocyte, Hyperplasia, Nodular     |                                                    3                     |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
      Kupffer Cell, Pigmentation           |                2                                                         |             
      Lobules, Necrosis                    |                               2  1                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +              +                       +   |             
      Infiltration Cellular, Histiocyte    |                                                                      3   |             
      Fat, Inflammation, Granulomatous     |                                                                          |             
      Fat, Necrosis                        |                               4              2                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                            2                                         2   |             
      Ectopic Tissue                       |                         X                                                |             
      Hyperplasia, Nodular                 |                                     1                 3                 2|             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                            1                                1            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                3                                                         |             
      Inflammation, Chronic                |                3     3                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 7| 1| 3| 3| 1| 3| 3| 3| 3| 2| 9| 3| 3| 3| 6| 3| 3| 3| 3| 7| 0| 3| 3| 3|             
                                           | 2| 4| 1| 2| 2| 5| 1| 1| 1| 2| 0| 8| 1| 1| 2| 4| 2| 2| 2| 2| 4| 1| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                      3                                                   |             
      Mineralization                       |                                  2                                       |             
      Ulcer                                |                   3                                                      |             
      Mucosa, Hyperplasia                  |                   3  3     1                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                2                                                         |             
      Inflammation, Granulomatous          |                                                                          |             
      Mineralization                       |                                  2                             2         |             
      Ulcer                                |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2     3                          1     2     2        2     1  1     3|             
      Myocardium, Inflammation, Chronic    |                      1                                               1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |       X           X  X           X                                       |             
      Angiectasis                          |          2                                            2                 2|             
      Clear Cell Focus                     |             X                             X              X  X     X      |             
      Hyperplasia                          |          1                                                        3      |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                      X   |             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          |                                                       2                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |             3                                                            |             
      Pars Distalis, Cyst                  |       X                 X  X     X  X        X                       X   |             
      Pars Distalis, Hyperplasia           |             2           3  3                                             |             
      Pars Distalis, Pigmentation          |                                                                          |             
      Pars Nervosa, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |                      1                          3     1                  |             
      Follicle, Cyst                       |                                                             X            |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 7| 1| 3| 3| 1| 3| 3| 3| 3| 2| 9| 3| 3| 3| 6| 3| 3| 3| 3| 7| 0| 3| 3| 3|             
                                           | 2| 4| 1| 2| 2| 5| 1| 1| 1| 2| 0| 8| 1| 1| 2| 4| 2| 2| 2| 2| 4| 1| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Ectasia                              |                4                                                         |             
      Hyperplasia                          |                2                          3                              |             
      Inflammation, Chronic                |          2  2                 2           3                              |             
      Inflammation, Suppurative            |             2                             3                              |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                    X           X         |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                               4     2                                    |             
      Hyperplasia, Cystic                  |                                                 2  2                     |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |       +     +                                               +            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |             +                    +                                       |             
      Anemia                               |                                  3                                       |             
      Leukocytosis                         |             X                                                            |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Reticulum Cell          |                                        3                                 |             
      Myelofibrosis                        |                                                                          |             
      Proliferation                        |             3                    3                          3            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Lymphatic, Dilatation                |                                                                   3      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |                                                                          |             
      Hemorrhage                           |                                                                3         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                              3                           |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     | 2           4                 3  3                                       |             
      Hyperplasia, Re Cell                 |                                                                          |             
      Pigmentation, Hemosiderin            |                3                                                         |             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Cyst                                 |                         X                                                |             
      Fibrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 7| 1| 3| 3| 1| 3| 3| 3| 3| 2| 9| 3| 3| 3| 6| 3| 3| 3| 3| 7| 0| 3| 3| 3|             
                                           | 2| 4| 1| 2| 2| 5| 1| 1| 1| 2| 0| 8| 1| 1| 2| 4| 2| 2| 2| 2| 4| 1| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |    3  2  3     3  4  4  3  2  2  2  2  3  3     3  3  3  3  2  3  3  2  2|             
      Hyperplasia, Lobular                 |          3                 4                                      2  2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Fibrosis                             |                                                                          |             
      Inflammation, Suppurative            |                                                                      3   |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hyperostosis                |                      X                             X                     |             
      Femur, Hyperostosis                  |                      X                 X           X                     |             
      Sternum, Hyperostosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    X  X        X                                                         |             
      Hydrocephalus                        |                2                                                         |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |    1                                                                     |             
      Axon, White Matter, Degeneration     |                                                                          |             
      Gray Matter, Degeneration            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                              2                           |             
      Fibrosis                             |                               2                                          |             
      Infiltration Cellular, Histiocyte    |       1  1  1     1     1        1  1     1        1  1        1  2  1  1|             
      Inflammation, Chronic                |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                      3   |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
      Subpleura, Inflammation, Chronic     |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                        X                          X      |             
      Fungus                               |                                                                   X      |             
      Inflammation, Chronic                |                                                                   2      |             
      Mucosa, Metaplasia, Squamous         |                                                                   2      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 7| 1| 3| 3| 1| 3| 3| 3| 3| 2| 9| 3| 3| 3| 6| 3| 3| 3| 3| 7| 0| 3| 3| 3|             
                                           | 2| 4| 1| 2| 2| 5| 1| 1| 1| 2| 0| 8| 1| 1| 2| 4| 2| 2| 2| 2| 4| 1| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |    1  1        1  1  1  1                 1        1              1  2  1|             
      Retina, Atrophy                      | 2     3  3  3  2  3  3  3  3     2  3  1  3     2  3  2  2  3  2  3  3  3|             
      Sclera, Mineralization               |                1                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                        2                                 |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       | 2     2  2  2  2  2  2  1  1  3  2  2  2  1  2        3  2  1     1  2  3|             
      Nephropathy                          |       1     2  2  1  2  1  1     1           1  1  1           1  1     1|             
      Renal Tubule, Cytoplasmic Alteration |                                                                          |             
      Renal Tubule, Degeneration           |                                                                          |             
      Renal Tubule, Necrosis               |                               2                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 3| 1| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 9| 3| 3| 3| 7| 8| 3| 3| 3|            |
                                           | 4| 0| 2| 2| 2| 9| 2| 2| 2| 2| 3| 3| 3| 3| 3| 8| 5| 2| 2| 2| 9| 1| 2| 2| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                 X                        |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                   X                 X                 X                  |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
      Parasite Metazoan                    |                                                       X  X        X      |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                         3|      1  3.0|
      Basophilic Focus                     |       X  X  X  X  X  X  X  X     X  X  X  X     X  X  X  X     X  X  X  X|     41     |
      Clear Cell Focus                     |                         X                 X                              |      2     |
      Developmental Malformation           |    X                    X                                   X            |      4     |
      Focal Cellular Change                |    X                             X                    X                  |      3     |
      Granuloma                            |    4              3        3  2     1     2                    1         |     13  2.1|
      Hematopoietic Cell Proliferation     |                                                                          |      2  1.5|
      Inflammation, Chronic                |                                        1                                 |      4  1.5|
      Mixed Cell Focus                     |                                                                          |      1     |
      Bile Duct, Cyst Multilocular         |                                                                          |      1     |
      Bile Duct, Hyperplasia               |    1        1  2  1  1        1  1     1        1  1        1  1  1  1  1|     25  1.1|
      Centrilobular, Atrophy               | 2                                                                        |      1  2.0|
      Hepatocyte, Hyperplasia, Nodular     |                2                                                         |      2  2.5|
      Hepatocyte, Vacuolization Cytoplasmic|    2                          2              4                           |      3  2.7|
      Kupffer Cell, Pigmentation           |                                                             3            |      2  2.5|
      Lobules, Necrosis                    |                                                          1               |      3  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                 +  +                    +              +  +         |   9        |
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
      Fat, Inflammation, Granulomatous     |                         3                                      3         |      2  3.0|
      Fat, Necrosis                        |    3                 3  4                                      3         |      6  3.2|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                            1        1                                    |      4  1.5|
      Ectopic Tissue                       |                                                                          |      1     |
      Hyperplasia, Nodular                 |                1  2                                                      |      5  1.8|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                         +|   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 3| 1| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 9| 3| 3| 3| 7| 8| 3| 3| 3|            |
                                           | 4| 0| 2| 2| 2| 9| 2| 2| 2| 2| 3| 3| 3| 3| 3| 8| 5| 2| 2| 2| 9| 1| 2| 2| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                2         |      2  2.5|
      Inflammation, Chronic                |                                                                          |      2  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  3.0|
      Mucosa, Hyperplasia                  |                      1                             1                     |      5  1.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |       1                                                                  |      1  1.0|
      Mineralization                       |       2  2  1                                                            |      5  1.8|
      Ulcer                                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |       2     2        1  2  1           1  3        2     2     2        1|     20  1.8|
      Myocardium, Inflammation, Chronic    |                            1  1                 1        1           1   |      7  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                               X                    X     X  X            |      8     |
      Angiectasis                          |       2  2                                                               |      5  2.0|
      Clear Cell Focus                     |    X  X        X     X                                                   |      9     |
      Hyperplasia                          |    1              3                                      2           2   |      6  2.0|
      Vacuolization Cytoplasmic, Diffuse   |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1     |
      Fibrosis                             |                                                             2            |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |                4                    3                                    |      3  3.3|
      Pars Distalis, Cyst                  |                   X  X              X  X                 X           X  X|     14     |
      Pars Distalis, Hyperplasia           |                                     2                                    |      4  2.5|
      Pars Distalis, Pigmentation          |                3                                                         |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 3| 1| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 9| 3| 3| 3| 7| 8| 3| 3| 3|            |
                                           | 4| 0| 2| 2| 2| 9| 2| 2| 2| 2| 3| 3| 3| 3| 3| 8| 5| 2| 2| 2| 9| 1| 2| 2| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Nervosa, Hyperplasia            |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                X                                                         |      1     |
      C-Cell, Hyperplasia                  |       1                                               3     1  2         |      7  1.7|
      Follicle, Cyst                       |                                                                          |      1     |
      Follicular Cell, Hyperplasia         |                                                                         2|      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  M  +  +|  45        |
      Ectasia                              |    2     4     3                                               2        2|      6  2.8|
      Hyperplasia                          |                                                                         2|      3  2.3|
      Inflammation, Chronic                |                                                          2              2|      6  2.2|
      Inflammation, Suppurative            |    1     2              4                                   2            |      6  2.3|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                 3                        |      1  3.0|
      Cyst                                 |    X                       X                                             |      4     |
      Hemorrhage                           |                                                 3                        |      1  3.0|
      Inflammation, Chronic                |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hydrometra                           |                                                                          |      2  3.0|
      Hyperplasia, Cystic                  |                2     1                                                   |      4  1.8|
      Inflammation, Suppurative            |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                              +     +        +  +         |   7        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   2        |
      Anemia                               |                                                                          |      1  3.0|
      Leukocytosis                         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Reticulum Cell          |                   2              2                                       |      3  2.3|
      Myelofibrosis                        |                                                             2            |      1  2.0|
      Proliferation                        |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  I|  46        |
      Hyperplasia, Plasma Cell             |                                                             2            |      1  2.0|
      Lymphatic, Dilatation                | 2                                                                        |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 3| 1| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 9| 3| 3| 3| 7| 8| 3| 3| 3|            |
                                           | 4| 0| 2| 2| 2| 9| 2| 2| 2| 2| 3| 3| 3| 3| 3| 8| 5| 2| 2| 2| 9| 1| 2| 2| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Depletion Cellular                   |                                                             3            |      1  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  3.0|
      Fibrosis                             |                                                             2            |      1  2.0|
      Hematopoietic Cell Proliferation     |             2              2                                             |      6  2.7|
      Hyperplasia, Re Cell                 |             3                                                            |      1  3.0|
      Pigmentation, Hemosiderin            |                                                 3           2            |      3  2.7|
      Red Pulp, Atrophy                    |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +|  47        |
      Cyst                                 |                                                                          |      1     |
      Fibrosis                             |                                     2                                    |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  |    4  4  4  3  2  2  2  4  4  3  3  2  1  2     1  2  4  3     2     2  3|     43  2.7|
      Hyperplasia, Lobular                 |          3                          2        4        3                  |      8  2.9|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           | 4                                                                        |      1  4.0|
      Fibrosis                             | 4                                                                        |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Ulcer                                | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Hyperostosis                |          X        X     X                          X                     |      6     |
      Femur, Hyperostosis                  |          X        X                       X        X                     |      7     |
      Sternum, Hyperostosis                |                         X                                                |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |    X                          X                 X              X         |      7     |
      Hydrocephalus                        |                                                                2         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Chronic                |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Axon, White Matter, Degeneration     |    2                                                                     |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 3| 1| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 9| 3| 3| 3| 7| 8| 3| 3| 3|            |
                                           | 4| 0| 2| 2| 2| 9| 2| 2| 2| 2| 3| 3| 3| 3| 3| 8| 5| 2| 2| 2| 9| 1| 2| 2| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Gray Matter, Degeneration            |                      1                          1                        |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                 3                        |      2  2.5|
      Fibrosis                             |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |    1  1  1        1  1  1           1  1  1                       2  1  3|     26  1.2|
      Inflammation, Chronic                |                                                                         3|      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                   2                                                      |      2  2.5|
      Mediastinum, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                             4            |      1  4.0|
      Subpleura, Inflammation, Chronic     |                                                                          |            |
          Active                           |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Exudate                              |                                        X                       X         |      4     |
      Fungus                               |                                                                          |      1     |
      Inflammation, Chronic                |                                                       2                  |      2  2.0|
      Mucosa, Metaplasia, Squamous         |                                                       2                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cataract                             |       1  1  1  2  1  1                 1  1     1     1                  |     21  1.1|
      Retina, Atrophy                      | 2  2  3  3  2  3  3  3  2  3     3  3  2  1        3  2  3  1     3  3  3|     43  2.6|
      Sclera, Mineralization               |       1  1     1                       1                                 |      5  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |                                                                          |      1  2.0|
      Inflammation, Chronic                |                1                          1                             1|      3  1.0|
      Mineralization                       | 1  2  1  2  2     1  1  1  3  1     2     1  1  3  1  2  1  2  1  2  2  2|     43  1.7|
      Nephropathy                          | 1  1  1  1  1  1  1  1           1  1     2        1  1  1  1  2  1  1  1|     33  1.2|
      Renal Tubule, Cytoplasmic Alteration | 3                                                                        |      1  3.0|
      Renal Tubule, Degeneration           |                            3                          2                  |      2  2.5|
      Renal Tubule, Necrosis               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 2| 2| 7| 7| 7| 5| 5| 7| 7| 7| 1| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 6| 5| 7| 9| 3| 3| 5| 3| 3| 3| 2| 2| 3| 3| 3| 5| 3| 3| 3| 3|             
                                           | 9| 0| 0| 0| 0| 1| 2| 6| 5| 0| 1| 0| 0| 0| 0| 0| 1| 0| 0| 0| 9| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    400.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                        X           X  X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +     +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X  X  X  X     X  X     X        X  X  X  X  X  X  X  X        X  X   |             
      Clear Cell Focus                     |                                                                          |             
      Developmental Malformation           |                                     X              X                     |             
      Focal Cellular Change                |                            X                             X               |             
      Granuloma                            |          1                          4  3  2     1  2  1  3        3  2   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic                | 2           1                                         1                  |             
      Bile Duct, Hyperplasia               |    3  1                                      2     1     1     1        2|             
      Centrilobular, Atrophy               |    2           2        2                                                |             
      Hepatocyte, Hyperplasia, Nodular     |    2  2           2     2                    2                 2         |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
      Kupffer Cell, Pigmentation           |                         3                                               2|             
      Lobules, Necrosis                    |          1                    1     1                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                   +               |             
      Accessory Spleen                     |                                                                          |             
      Artery, Hypertrophy                  |                                                          4               |             
      Artery, Inflammation, Chronic Active |                                                          4               |             
      Fat, Inflammation, Granulomatous     |                      3                                                   |             
      Fat, Inflammation, Suppurative       |                      3                                                   |             
      Fat, Mineralization                  |                                                                          |             
      Fat, Necrosis                        |                      3                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                           1        1                     |             
      Hyperplasia, Nodular                 |          2                                2                          2   |             
      Inflammation, Chronic                |                                                    1           2         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                      2                                                   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 2| 2| 7| 7| 7| 5| 5| 7| 7| 7| 1| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 6| 5| 7| 9| 3| 3| 5| 3| 3| 3| 2| 2| 3| 3| 3| 5| 3| 3| 3| 3|             
                                           | 9| 0| 0| 0| 0| 1| 2| 6| 5| 0| 1| 0| 0| 0| 0| 0| 1| 0| 0| 0| 9| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    400.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |                                           2                              |             
      Inflammation, Chronic                |                                           2                              |             
      Ulcer                                |                   2                                                      |             
      Mucosa, Hyperplasia                  | 1                 2                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              | 2                             1                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       2     1           1  2        2  2           1     2     1  1     1|             
      Thrombosis                           |                         X                                                |             
      Epicardium, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                       2                  |             
      Myocardium, Inflammation, Chronic    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    | X                                                                 X      |             
      Angiectasis                          |                                        2                 3        2      |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     | X              X                    X                             X      |             
      Hemorrhage                           |                                              2              3            |             
      Hyperplasia                          |    1                          2                    2  2                  |             
      Necrosis                             | 3                    2                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         3                                                |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Pars Distalis, Angiectasis           | 2           2           3                             3                  |             
      Pars Distalis, Cyst                  | X     X                                            X  X                  |             
      Pars Distalis, Hyperplasia           | 2           2                                      2  1                  |             
      Pars Distalis, Pigmentation          |                                                                          |             
      Pars Intermedia, Cyst                |                                                    X                     |             
      Pars Intermedia, Hyperplasia         |                                                    2                     |             
      Pars Nervosa, Hyperplasia            |                                                       2                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                       X                  |             
      C-Cell, Hyperplasia                  |          1                          2                                   2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 2| 2| 7| 7| 7| 5| 5| 7| 7| 7| 1| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 6| 5| 7| 9| 3| 3| 5| 3| 3| 3| 2| 2| 3| 3| 3| 5| 3| 3| 3| 3|             
                                           | 9| 0| 0| 0| 0| 1| 2| 6| 5| 0| 1| 0| 0| 0| 0| 0| 1| 0| 0| 0| 9| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    400.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |          3                                         3              4     3|             
      Hyperplasia                          |                                              2        2        3        2|             
      Inflammation, Chronic                |       3                                               3                  |             
      Inflammation, Suppurative            |       3              3              2        4     3           4  4     2|             
      Metaplasia, Squamous                 |                      3                                                   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           X  X                       X  X|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                       3                  |             
      Cyst                                 |                                                       X                  |             
      Hemorrhage                           |             3                                                            |             
      Hydrometra                           |                         3                                                |             
      Hyperplasia, Cystic                  |       2     2                          3                                 |             
      Inflammation, Suppurative            |                                                                   4      |             
      Necrosis                             |             3                                                            |             
      Endometrium, Dysplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                         +                       M                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +                    +                                                |             
      Anemia                               |    3                    3                                                |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Reticulum Cell          |                                     3  2           1                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Lymphatic, Dilatation                |                                                                3         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                       2                  |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Re Cell                 |                                     4                                    |             
      Pigmentation, Hemosiderin            |                      4        3  3              3                        |             
      Lymphoid Follicle, Atrophy           |                                                                          |             
      Red Pulp, Atrophy                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 2| 2| 7| 7| 7| 5| 5| 7| 7| 7| 1| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 6| 5| 7| 9| 3| 3| 5| 3| 3| 3| 2| 2| 3| 3| 3| 5| 3| 3| 3| 3|             
                                           | 9| 0| 0| 0| 0| 1| 2| 6| 5| 0| 1| 0| 0| 0| 0| 0| 1| 0| 0| 0| 9| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    400.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 3  4  2     2     2  3  3  2              2  2  2  2     2     2  2  2  2|             
      Hyperplasia, Lobular                 |          1                                                               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Granulomatous                   |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hyperostosis                |                                                          X               |             
      Femur, Hyperostosis                  |                                                          X               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                      X                                                   |             
      Hemorrhage                           |                      3                                                   |             
      Hydrocephalus                        |                                                                          |             
      Inflammation, Chronic                |                                                       1                  |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                       1                  |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gray Matter, Degeneration            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                  4                          3            |             
      Infiltration Cellular, Histiocyte    |             1  1        1           1     1           1  1        1  1   |             
      Inflammation, Suppurative            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                      X  X                                                |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |          X                                                               |             
      Inflammation, Chronic                |          3                                                               |             
      Mucosa, Metaplasia, Squamous         |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 2| 2| 7| 7| 7| 5| 5| 7| 7| 7| 1| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 6| 5| 7| 9| 3| 3| 5| 3| 3| 3| 2| 2| 3| 3| 3| 5| 3| 3| 3| 3|             
                                           | 9| 0| 0| 0| 0| 1| 2| 6| 5| 0| 1| 0| 0| 0| 0| 0| 1| 0| 0| 0| 9| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    400.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |       3  2  2     1        1        1        4     1           1  1     1|             
      Cornea, Inflammation, Chronic        |                                                                          |             
      Cornea, Neovascularization           |                                                                          |             
      Retina, Atrophy                      | 1  3  3  2  3  2     3  3  3        2  3  3  1     3  3  2     3  3  3  3|             
      Sclera, Mineralization               |                                     1                          2         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                       2                  |             
      Hemorrhage                           |                                                 3                        |             
      Infarct                              |                                                       3                  |             
      Inflammation, Chronic                |                            1                                             |             
      Inflammation, Suppurative            |                         1                       3                        |             
      Mineralization                       | 2  2  2  1  2  1  2  1  1  2           2     1     3  2  2     3  1  2  1|             
      Nephropathy                          |    1  1  1  1        2  1  1           1  1           1  1        1  1  1|             
      Renal Tubule, Dilatation             |                                                 2                        |             
      Renal Tubule, Necrosis               |                                                 2                        |             
      Renal Tubule, Pigmentation           |                         2                    3                           |             
      Transitional Epithelium, Hyperplasia |                         1                                                |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                 3                        |             
      Inflammation, Suppurative            |                                                 3                        |             
      Mineralization                       |                      2                                                   |             
      Ulcer                                |                                                                          |             
      Mucosa, Hyperplasia                  |    1                                            3                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 7| 7| 7| 2| 7| 7| 7| 7| 5| 6| 5| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 5| 1| 3| 3| 7| 3| 3| 3| 3| 5| 1| 7| 5| 9| 8| 3| 3| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 8| 1| 1| 0| 0| 5| 1| 1| 1| 1| 4| 3| 0| 9| 2| 5| 1| 1| 1| 1| 8| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    400.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |          X                                            X                  |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                   X                                                      |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                            X                 X     X                 X  X|      5     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Erosion                              |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |          X  X     X  X  X  X     X  X     X  X  X  X  X  X  X  X  X  X  X|     36     |
      Clear Cell Focus                     |          X                 X                                   X         |      3     |
      Developmental Malformation           | X           X                       X                          X  X      |      7     |
      Focal Cellular Change                |                                                                          |      2     |
      Granuloma                            |          1  2           1  3  1  1                    2  3  1  1     1   |     21  1.9|
      Hematopoietic Cell Proliferation     |                                  1                                       |      1  1.0|
      Inflammation, Chronic                |                                                                          |      3  1.3|
      Bile Duct, Hyperplasia               |          1           1     1                    1              1         |     12  1.3|
      Centrilobular, Atrophy               |                                        2                                 |      4  2.0|
      Hepatocyte, Hyperplasia, Nodular     |                                        3                                 |      7  2.1|
      Hepatocyte, Vacuolization Cytoplasmic|                               2                                          |      1  2.0|
      Kupffer Cell, Pigmentation           |                                        2                                 |      3  2.3|
      Lobules, Necrosis                    |                                        2                                 |      4  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                             +           +  +               |   6        |
      Accessory Spleen                     |                                                       X                  |      1     |
      Artery, Hypertrophy                  |             2                                                            |      2  3.0|
      Artery, Inflammation, Chronic Active |             2                                                            |      2  3.0|
      Fat, Inflammation, Granulomatous     |                                                                          |      1  3.0|
      Fat, Inflammation, Suppurative       |                                                                          |      1  3.0|
      Fat, Mineralization                  |                                           4                              |      1  4.0|
      Fat, Necrosis                        |                                           4              3               |      3  3.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      2  1.0|
      Hyperplasia, Nodular                 |                   2                             2                        |      5  2.0|
      Inflammation, Chronic                |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 7| 7| 7| 2| 7| 7| 7| 7| 5| 6| 5| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 5| 1| 3| 3| 7| 3| 3| 3| 3| 5| 1| 7| 5| 9| 8| 3| 3| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 8| 1| 1| 0| 0| 5| 1| 1| 1| 1| 4| 3| 0| 9| 2| 5| 1| 1| 1| 1| 8| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    400.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Inflammation, Chronic                |                               2                                          |      2  2.0|
      Ulcer                                |                                                                          |      1  2.0|
      Mucosa, Hyperplasia                  |                               2                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                           2                              |      3  1.7|
      Inflammation, Granulomatous          |                                                                      1   |      1  1.0|
      Mineralization                       |                                        3                                 |      1  3.0|
      Ulcer                                |                                     3                                    |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |       2     1        1                             1     2  2        2  2|     19  1.5|
      Thrombosis                           |                                                                          |      1     |
      Epicardium, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
      Myocardium, Inflammation, Chronic    |                                                                         3|      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                           X                              |      3     |
      Angiectasis                          |          2                       3                    2        3     2   |      8  2.4|
      Basophilic Focus                     |                                     X                                    |      1     |
      Clear Cell Focus                     |                         X              X                    X        X   |      8     |
      Hemorrhage                           |                                                                          |      2  2.5|
      Hyperplasia                          |                                                                         2|      5  1.8|
      Necrosis                             |    3                                                                     |      3  2.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 7| 7| 7| 2| 7| 7| 7| 7| 5| 6| 5| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 5| 1| 3| 3| 7| 3| 3| 3| 3| 5| 1| 7| 5| 9| 8| 3| 3| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 8| 1| 1| 0| 0| 5| 1| 1| 1| 1| 4| 3| 0| 9| 2| 5| 1| 1| 1| 1| 8| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    400.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Angiectasis           |             2                                   4  2                 2   |      8  2.5|
      Pars Distalis, Cyst                  |                                  X  X  X  X  X                           |      9     |
      Pars Distalis, Hyperplasia           |             2           2        2     3        2           2            |     10  2.0|
      Pars Distalis, Pigmentation          |                                        2           2                     |      2  2.0|
      Pars Intermedia, Cyst                |                                                                          |      1     |
      Pars Intermedia, Hyperplasia         |                                                                          |      1  2.0|
      Pars Nervosa, Hyperplasia            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                                                          |      1     |
      C-Cell, Hyperplasia                  |                               1           1                 1  2         |      7  1.4|
      Follicular Cell, Hyperplasia         |                                  2                                       |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
      Ectasia                              |                               3                          3              3|      7  3.1|
      Hyperplasia                          |                               3                                   2     2|      7  2.3|
      Inflammation, Chronic                |                         2                                               2|      4  2.5|
      Inflammation, Suppurative            |                                                          4        3  3  2|     12  3.1|
      Metaplasia, Squamous                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                               X                       X                 X|      7     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      1     |
      Hemorrhage                           |                               4                                          |      2  3.5|
      Hydrometra                           |                                                                          |      1  3.0|
      Hyperplasia, Cystic                  |                               3                                          |      4  2.5|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  3.0|
      Endometrium, Dysplasia               |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |       +                       M                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   2        |
      Anemia                               |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 7| 7| 7| 2| 7| 7| 7| 7| 5| 6| 5| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 5| 1| 3| 3| 7| 3| 3| 3| 3| 5| 1| 7| 5| 9| 8| 3| 3| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 8| 1| 1| 0| 0| 5| 1| 1| 1| 1| 4| 3| 0| 9| 2| 5| 1| 1| 1| 1| 8| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    400.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Reticulum Cell          |                                                       2        2         |      5  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Hyperplasia, Plasma Cell|                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +|  47        |
      Hyperplasia, Plasma Cell             |                                        3                          3      |      2  3.0|
      Lymphatic, Dilatation                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                3                                                         |      2  2.5|
      Pigmentation                         |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                  2  2                       2     2      |      4  2.0|
      Hyperplasia, Re Cell                 |                                                                          |      1  4.0|
      Pigmentation, Hemosiderin            |                3                    2     4                              |      7  3.1|
      Lymphoid Follicle, Atrophy           |                                           3                              |      1  3.0|
      Red Pulp, Atrophy                    |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  +  +  +  +  +  +|  46        |
      Cyst                                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  |       3  2  2  2     1  2  3  2     1  3  3     3     2        2  2      |     32  2.3|
      Hyperplasia, Lobular                 |                                                 3                    3   |      3  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Granulomatous                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Hyperostosis                |                                                                          |      1     |
      Femur, Hyperostosis                  |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |       X                       X                                          |      3     |
      Hemorrhage                           |                                           1                              |      2  2.0|
      Hydrocephalus                        |                               2                                          |      1  2.0|
      Inflammation, Chronic                |                                                 2                        |      2  1.5|
      Vacuolization Cytoplasmic            |                                                 2                        |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 7| 7| 7| 2| 7| 7| 7| 7| 5| 6| 5| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 5| 1| 3| 3| 7| 3| 3| 3| 3| 5| 1| 7| 5| 9| 8| 3| 3| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 8| 1| 1| 0| 0| 5| 1| 1| 1| 1| 4| 3| 0| 9| 2| 5| 1| 1| 1| 1| 8| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    400.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Gray Matter, Degeneration            |                                                       1                  |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           | 3  3                                                                     |      4  3.3|
      Infiltration Cellular, Histiocyte    |          1                       1           1     1                    1|     14  1.0|
      Inflammation, Suppurative            |                                        2                                 |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                        3                    4            |      2  3.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Exudate                              |                      X     X  X        X                                 |      6     |
      Mucosa, Hyperplasia                  |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Exudate                              |                                                                          |      1     |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Mucosa, Metaplasia, Squamous         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cataract                             |       1  2  1     1     2  4              1        1  3  1  1  1  1     1|     25  1.6|
      Cornea, Inflammation, Chronic        |                            2                                             |      1  2.0|
      Cornea, Neovascularization           |                            2                                             |      1  2.0|
      Retina, Atrophy                      |       3  3  3     3  2  3  4  2  2     3  2     3  3  3  3  3  3  3  3  3|     40  2.7|
      Sclera, Mineralization               |                         2              1     1     1                     |      6  1.3|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Infarct                              |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                                     2                                    |      3  2.0|
      Mineralization                       |       2  1  2     2  1  2  2  2  1  2  1  2  1  2  2  1  1  1  2  2  1  2|     41  1.7|
      Nephropathy                          |       1  1  1     1  1  1  1  3  1  2  1  1     1  1  1  1     1  1  1  1|     34  1.1|
      Renal Tubule, Dilatation             |                2                                                         |      2  2.0|
      Renal Tubule, Necrosis               |                                                                          |      1  2.0|
      Renal Tubule, Pigmentation           |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 7| 7| 7| 2| 7| 7| 7| 7| 5| 6| 5| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 5| 1| 3| 3| 7| 3| 3| 3| 3| 5| 1| 7| 5| 9| 8| 3| 3| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 8| 1| 1| 0| 0| 5| 1| 1| 1| 1| 4| 3| 0| 9| 2| 5| 1| 1| 1| 1| 8| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    400.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Transitional Epithelium, Hyperplasia |                                     3                                    |      2  2.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                     +                                    |   1        |
      Calculus Micro Observation Only      |                                     X                                    |      1     |
      Inflammation, Suppurative            |                                     4                                    |      1  4.0|
      Mucosa, Hyperplasia                  |                                     4                                    |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  2.0|
      Ulcer                                |                                     4                                    |      1  4.0|
      Mucosa, Hyperplasia                  |                                     4                                    |      3  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 8| 2| 3| 3| 3| 3| 3| 3| 3| 9| 9| 1| 3| 3| 2| 9| 3| 3| 3| 1| 9| 3| 3| 3|             
                                           | 1| 3| 0| 0| 0| 0| 0| 0| 0| 0| 5| 7| 8| 0| 0| 8| 7| 0| 0| 0| 3| 6| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                                                +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                                                +         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    3           3                                               3         |             
      Basophilic Focus                     |    X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X     X  X     X|             
      Clear Cell Focus                     |                      X                    X                              |             
      Developmental Malformation           |                               X                          X              X|             
      Granuloma                            |    1     1     2  1                 2                          1         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic                |       1  2        2           1                 1                        |             
      Mixed Cell Focus                     |                                                                          |             
      Bile Duct, Hyperplasia               |          1  1           1  2           3           3     2  2        3   |             
      Centrilobular, Atrophy               |                                  2     2                    3        2   |             
      Hepatocyte, Hyperplasia, Nodular     |                3                 3     3                             2   |             
      Hepatocyte, Vacuolization Cytoplasmic|       2                                1                                 |             
      Kupffer Cell, Hyperplasia            |                                                                          |             
      Lobules, Necrosis                    |                2     1                                   2               |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +  +                                +  +                    +   |             
      Fat, Inflammation, Chronic           |          3                                                               |             
      Fat, Inflammation, Granulomatous     |          2  2                                                            |             
      Fat, Mineralization                  |             1                                3                       2   |             
      Fat, Necrosis                        |          3  3                                3  3                    4   |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                                +         |             
      Atrophy                              |                                                                2         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
      Mucosa, Dysplasia                    |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Erosion                              | 3                                                                        |             
      Mineralization                       |             2     2                                      3           3  2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |          2                 1              1  1     1              1      |             
      Myocardium, Inflammation, Chronic    |    2           1                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 8| 2| 3| 3| 3| 3| 3| 3| 3| 9| 9| 1| 3| 3| 2| 9| 3| 3| 3| 1| 9| 3| 3| 3|             
                                           | 1| 3| 0| 0| 0| 0| 0| 0| 0| 0| 5| 7| 8| 0| 0| 8| 7| 0| 0| 0| 3| 6| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Myocardium, Mineralization           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                            X                                            X|             
      Angiectasis                          |          3  2        2                             2     2               |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                X           X                       X  X     X            |             
      Cyst Multilocular                    |                                                                          |             
      Hyperplasia                          |                      3                                                   |             
      Vacuolization Cytoplasmic, Diffuse   |                      3           2                                       |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             1                    2                       1               |             
      Inflammation, Chronic                |          1                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                                                +         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |    X     X  X  X                 X                    X     X     X  X   |             
      Pars Distalis, Hyperplasia           |    1                             2                                2      |             
      Pars Distalis, Pigmentation          |                                                                          |             
      Pars Intermedia, Angiectasis         |                                                                          |             
      Pars Intermedia, Cyst                |                                                                      X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                                                                      +   |             
      C-Cell, Hyperplasia                  |                                                                      2   |             
      Follicle, Cyst                       |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                         1                                                |             
      Inflammation, Suppurative            |                                                       2                  |             
                                            __________________________________________________________________________|             
   Ovary                                   |                                                       +                  |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +                                +              +                       +|             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hydrometra                           |                                                                          |             
      Hyperplasia, Cystic                  |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 8| 2| 3| 3| 3| 3| 3| 3| 3| 9| 9| 1| 3| 3| 2| 9| 3| 3| 3| 1| 9| 3| 3| 3|             
                                           | 1| 3| 0| 0| 0| 0| 0| 0| 0| 0| 5| 7| 8| 0| 0| 8| 7| 0| 0| 0| 3| 6| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                  +     +                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Anemia                               |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +                                                            |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Fibrosis                             |                                                    3                     |             
      Hematopoietic Cell Proliferation     | 4                    2                          3              2        2|             
      Necrosis                             |                                                             4        3   |             
      Pigmentation, Hemosiderin            |       3                             3                          3         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  1  2  1  2     3  4  2  2  1  2  3  2  3  2  3  3  1  2  2  2  1  2  4|             
      Hyperplasia, Lobular                 |                   3        3     2     4                 4  4  2         |             
                                            __________________________________________________________________________|             
   Skin                                    |          +  +     +  +  +  +           +  +  +  +     +        +        +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Chronic                |                   1                                                      |             
      Nipple, Hypertrophy                  |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hyperostosis                |          X                       X                 X                     |             
      Femur, Hyperostosis                  |       X  X                                                           X   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |       X              X              X  X        X  X           X         |             
      Hydrocephalus                        |       2                                                                  |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                          1               |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Gray Matter, Degeneration            |                                                                   1      |             
      Parenchyma, White Matter,            |                                                                          |             
          Degeneration, Multifocal         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 8| 2| 3| 3| 3| 3| 3| 3| 3| 9| 9| 1| 3| 3| 2| 9| 3| 3| 3| 1| 9| 3| 3| 3|             
                                           | 1| 3| 0| 0| 0| 0| 0| 0| 0| 0| 5| 7| 8| 0| 0| 8| 7| 0| 0| 0| 3| 6| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                         1           1        2     3        1  1        2|             
      Inflammation, Chronic                |                                                          1               |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |          1  1        1           3     1                 1     1        1|             
      Hemorrhage                           |                                                                          |             
      Retina, Atrophy                      |       2  3  3     2  2  2        4  2  2     1  2  3  1  3  2  3  3  3  3|             
      Sclera, Mineralization               |          1              2                                      1         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 | X                                                           X            |             
      Hydronephrosis                       | 2                                                                        |             
      Infarct                              |                                                                      2   |             
      Inflammation, Chronic                | 1              2  2     1                                         1      |             
      Inflammation, Suppurative            |             1                                                            |             
      Mineralization                       | 2     2  2  1     1  1  1  2  2  2  1  1  2  2  1  2  1  1  1  2  1  3  2|             
      Nephropathy                          |    2  2  1  1  1     2  1  1     1  1  2        1  1  1     1  1  1  1  2|             
      Papilla, Necrosis                    |                                                                          |             
      Renal Tubule, Degeneration           |                      3                          3                    4   |             
      Transitional Epithelium, Hyperplasia |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 4| 6| 3| 3| 3| 5| 8| 3| 3| 3| 6| 8| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 1| 1| 1| 1| 2| 9| 1| 1| 1| 2| 4| 1| 1| 1| 8| 2| 1| 1| 1| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    200.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                 +                        |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                 +                        |   2        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |       2                                                                  |      4  2.8|
      Basophilic Focus                     | X  X  X  X  X  X     X  X  X  X  X  X  X  X        X  X  X  X  X  X  X  X|     43     |
      Clear Cell Focus                     |             X                 X                                          |      4     |
      Developmental Malformation           |                X  X                       X  X     X     X  X            |     10     |
      Granuloma                            |          3                       2  1                 1     3  4  3  3  2|     15  2.0|
      Hematopoietic Cell Proliferation     |                   1                                1                     |      2  1.0|
      Inflammation, Chronic                |    1                    1                                1     2         |      9  1.3|
      Mixed Cell Focus                     |                                                                      X   |      1     |
      Bile Duct, Hyperplasia               |    1           1        2  1        2  1  1     2     1                 1|     19  1.6|
      Centrilobular, Atrophy               |                                                 3                        |      5  2.4|
      Hepatocyte, Hyperplasia, Nodular     |                                     2                                    |      5  2.6|
      Hepatocyte, Vacuolization Cytoplasmic|                                              1  4                        |      4  2.0|
      Kupffer Cell, Hyperplasia            |                                              2                           |      1  2.0|
      Lobules, Necrosis                    |                   2                    1                       1         |      6  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
      Fat, Inflammation, Chronic           |                                                                          |      1  3.0|
      Fat, Inflammation, Granulomatous     |                                                                          |      2  2.0|
      Fat, Mineralization                  |                                                                          |      3  2.0|
      Fat, Necrosis                        |                                                                          |      5  3.2|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                   +                                                      |   2        |
      Atrophy                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                   2                                                      |      1  2.0|
      Mucosa, Dysplasia                    |          4                                                               |      1  4.0|
      Mucosa, Hyperplasia                  |          4        4                                                      |      2  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                     X                                    |      1     |
      Erosion                              |                                                                          |      1  3.0|
      Mineralization                       | 2                    1     2                                             |      8  2.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 4| 6| 3| 3| 3| 5| 8| 3| 3| 3| 6| 8| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 1| 1| 1| 1| 2| 9| 1| 1| 1| 2| 4| 1| 1| 1| 8| 2| 1| 1| 1| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    200.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    1           1        2  1     1  1     2                          1  2|     15  1.3|
      Myocardium, Inflammation, Chronic    |          1     1                    1                       1  1     1   |      8  1.1|
      Myocardium, Mineralization           |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |    X           X     X              X        X  X                        |      8     |
      Angiectasis                          |                               2  3                                       |      7  2.3|
      Basophilic Focus                     |             X                                                            |      1     |
      Clear Cell Focus                     |                   X                          X  X  X     X               |     10     |
      Cyst Multilocular                    |                                                                         X|      1     |
      Hyperplasia                          |       2                    3        2           3                        |      5  2.6|
      Vacuolization Cytoplasmic, Diffuse   |                               3                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |       1                                                                  |      4  1.3|
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                 +                        |   2        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |    3                                3  4                                3|      4  3.3|
      Pars Distalis, Cyst                  |                      X     X        X  X  X              X               |     15     |
      Pars Distalis, Hyperplasia           |                                                 2                        |      4  1.8|
      Pars Distalis, Pigmentation          |                                                 3                        |      1  3.0|
      Pars Intermedia, Angiectasis         |                                                 2                        |      1  2.0|
      Pars Intermedia, Cyst                |                                                 X                        |      2     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                               +     +                                +   |   4        |
      C-Cell, Hyperplasia                  |                                                                          |      1  2.0|
      Follicle, Cyst                       |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                               3                       2                  |      2  2.5|
      Hyperplasia                          |                                  2                                       |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 4| 6| 3| 3| 3| 5| 8| 3| 3| 3| 6| 8| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 1| 1| 1| 1| 2| 9| 1| 1| 1| 2| 4| 1| 1| 1| 8| 2| 1| 1| 1| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    200.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |          1                       2        1     2     3                  |      6  1.7|
      Inflammation, Suppurative            |                                  2                                       |      2  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |                      +  +                                                |   3        |
      Cyst                                 |                      X  X                                                |      2     |
                                            __________________________________________________________________________|____________|
   Uterus                                  |          +           +           +     +              +  +     +  +      |  12        |
      Cyst                                 |                                        X                 X        X      |      3     |
      Hemorrhage                           |          4                                                               |      1  4.0|
      Hydrometra                           |                      4                                                   |      1  4.0|
      Hyperplasia, Cystic                  |                      3                                                   |      1  3.0|
      Inflammation, Suppurative            |                                        4                                 |      1  4.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                              +  +                        |   4        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                    +                     |   1        |
      Anemia                               |                                                    X                     |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                   +           +                 +           +            |   5        |
      Hyperplasia, Reticulum Cell          |                                                 4                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                           2                              |      1  2.0|
      Fibrosis                             |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     | 2        2        3                          2     3                     |     10  2.5|
      Necrosis                             |                                                                          |      2  3.5|
      Pigmentation, Hemosiderin            |                3     2           3           3                           |      7  2.9|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  |    3  3  3  2  2  2  2  3     3  3     1  2  3  3  4  3  1  2  3  1     2|     45  2.3|
      Hyperplasia, Lobular                 |          3                                         3        2            |     10  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +        +  +  +  +  +  +  +     +  +  +  +     +  +            |  29        |
      Acanthosis                           |                                                    2                     |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Nipple, Hypertrophy                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Hyperostosis                |       X                                X              X                 X|      7     |
      Femur, Hyperostosis                  |                X                       X              X                 X|      7     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 4| 6| 3| 3| 3| 5| 8| 3| 3| 3| 6| 8| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 1| 1| 1| 1| 2| 9| 1| 1| 1| 2| 4| 1| 1| 1| 8| 2| 1| 1| 1| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    200.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |       X     X  X  X           X  X           X  X  X                     |     16     |
      Hydrocephalus                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                              1                           |      1  1.0|
      Gray Matter, Degeneration            |                                                                          |      1  1.0|
      Parenchyma, White Matter,            |                                                                          |            |
          Degeneration, Multifocal         |                                                 2                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                  3        2                              |      2  2.5|
      Infiltration Cellular, Histiocyte    |    1              3        1     1  1                          1        1|     14  1.4|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     | 3                                                                 2      |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cataract                             |          2           3  1     3     3  1                 1  1  2  1     2|     19  1.6|
      Hemorrhage                           |                                  2                                       |      1  2.0|
      Retina, Atrophy                      | 3  2  3  3  1  1     3  3  3  4     3  3  3  2  3  3  2  3  3  3  3  3  3|     42  2.6|
      Sclera, Mineralization               | 1                    1  2                          1  3  3     2  1      |     11  1.6|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                        1                                 |      1  1.0|
      Cyst                                 |                                                                          |      2     |
      Hydronephrosis                       |                   3                                                      |      2  2.5|
      Infarct                              |                                                                          |      1  2.0|
      Inflammation, Chronic                |       2                 2                                                |      7  1.6|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Mineralization                       | 2  2  2  2  2  1  1     1  3  2  2  1  1  2  1     2  2  2  2  2  1  2   |     45  1.6|
      Nephropathy                          | 1  2  3  1  1  1  1  1  3  1  1     1  1  1  2  1  1  2  1     1     1  1|     41  1.3|
      Papilla, Necrosis                    |                   3                                                      |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 4| 6| 3| 3| 3| 5| 8| 3| 3| 3| 6| 8| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 1| 1| 1| 1| 2| 9| 1| 1| 1| 2| 4| 1| 1| 1| 8| 2| 1| 1| 1| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    200.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Degeneration           |                                                                          |      3  3.3|
      Transitional Epithelium, Hyperplasia |                               1                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 1| 2| 3| 3|             
                                           | 1| 1| 1| 1| 2| 2| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 5| 0| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Parasite Metazoan                    |    X                             X     X                 X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X  X                                X                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                            X           X  X        X              X      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X     X  X  X  X  X     X  X  X  X     X  X  X     X     X  X  X|             
      Clear Cell Focus                     |       X  X           X     X     X  X     X        X                 X   |             
      Developmental Malformation           |             X  X        X              X                             X   |             
      Focal Cellular Change                |    X                                X  X        X                        |             
      Granuloma                            | 2  2  2  2  2     2     1  3     2     2           2              1      |             
      Hemorrhage                           |                                                 2                        |             
      Inflammation, Chronic                |                      2                                                   |             
      Inflammation, Chronic Active         |                                                                          |             
      Bile Duct, Cyst Multilocular         |                                                                          |             
      Bile Duct, Hyperplasia               | 2  2  2  2  2  2  3  1  2  3  3  3  2  2  3  2  1  2  2  4  2  2  1  2  2|             
      Centrilobular, Atrophy               |                               3                                          |             
      Hepatocyte, Hyperplasia, Nodular     |                                                          3               |             
      Hepatocyte, Vacuolization Cytoplasmic| 3  2           2           3        2  2        2           2           2|             
      Lobules, Necrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +  +     +        +           +  +|             
      Artery, Hypertrophy                  |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                         3|             
      Fat, Inflammation, Granulomatous     |                                        3                                 |             
      Fat, Mineralization                  |                                                 3        3           2   |             
      Fat, Necrosis                        |                                        3  2     3        4           4   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Atrophy                              |                         1  2  1     1     1                              |             
      Hyperplasia, Nodular                 |                                                                   1      |             
      Inflammation, Chronic                |                      1     1                                      1      |             
      Inflammation, Granulomatous          |                                                                         3|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 1| 2| 3| 3|             
                                           | 1| 1| 1| 1| 2| 2| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 5| 0| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Perforation                          |                                                                          |             
      Mucosa, Dysplasia                    |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion                              |                                                             3            |             
      Inflammation, Chronic Active         |    2                                                                     |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                2         |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3     2  3  2  3  2     1  2  2  1  2  2  3     3     3        2  2  2  2|             
      Thrombosis                           |                                                                          |             
      Epicardium, Inflammation, Chronic    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                   X                       X                 X            |             
      Angiectasis                          |                                  2                 3                     |             
      Basophilic Focus                     |                                                             X            |             
      Clear Cell Focus                     | X                       X                                                |             
      Hyperplasia                          |                      3                          3                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2                                               1      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia                          |                            4                                             |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |    2                                                                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                2                 2                                       |             
      Pars Distalis, Cyst                  |                                        X                                 |             
      Pars Distalis, Hyperplasia           |                            2     1                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         | 2  1  1  2        2  1  1              1                       1     1   |             
      C-Cell, Hyperplasia                  |    2                          1                 1  2  2              1   |             
      Follicle, Cyst                       |                X     X                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 1| 2| 3| 3|             
                                           | 1| 1| 1| 1| 2| 2| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 5| 0| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |       3                                                                  |             
      Inflammation, Chronic                |    3     3  2  2  2  2  2  3  2  3     2  2     2  2  2  3     3         |             
      Inflammation, Suppurative            |                                                                3         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Corpora Amylacea                     |                1                                                         |             
      Ectasia                              |                                                                          |             
      Fibrosis                             |                         2                                                |             
      Inflammation, Chronic                | 1              1              1                    1     2               |             
      Inflammation, Suppurative            | 2     1     1           2     2  2           3           3     2         |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 2           2  1  2              2  3     2     3     2                 1|             
      Spermatocele                         |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                                2         |             
      Seminiferous Tubule, Atrophy         |                                                                      4   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Anemia                               |                                                                          |             
      Leukocytosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                      4   |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mediastinal, Erythrophagocytosis     |                                                                   3      |             
      Mediastinal, Hemorrhage              |                         3                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythrophagocytosis                  |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Lymphatic, Dilatation                |                               4  3                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Pigmentation                         | 2  2  2  2  2        1  1  2     2  2  2  2  2  2     1  1  2  3  2  1   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |       3                                                                  |             
      Hematopoietic Cell Proliferation     |                2                                            2     3      |             
      Hyperplasia, Re Cell                 |       3                                                                  |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             X              X                                             |             
      Epithelial Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 1| 2| 3| 3|             
                                           | 1| 1| 1| 1| 2| 2| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 5| 0| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 1     4     1  1              2              2           2               |             
      Hyperplasia, Lobular                 |       2           3                                                      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Sebaceous Gland, Ectasia             |                                                                          |             
      Subcutaneous Tissue, Fibrosis        |          3                                                           3   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                X         |             
      Hydrocephalus                        |                                              2                 3         |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                     1                                    |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gray Matter, Degeneration            |                                                                          |             
      Gray Matter, Necrosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomatosis                         |                                                                          |             
      Congestion                           |                                                                          |             
      Foreign Body                         |                                                    1                     |             
      Hemorrhage                           |          2                                                               |             
      Infiltration Cellular, Histiocyte    |    1  1     1  1        1           1  1        1  1        1            |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                  1                                       |             
      Alveolar Epithelium, Hyperplasia     |                                           2                              |             
      Alveolus, Edema                      |                                                                          |             
      Artery, Mediastinum, Hypertrophy     |                                                                          |             
      Artery, Mediastinum, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              | X        X     X              X                                         X|             
      Foreign Body                         |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 1| 2| 3| 3|             
                                           | 1| 1| 1| 1| 2| 2| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 5| 0| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Fungus                               | X              X              X                                          |             
      Inflammation, Chronic                | 3        3                                                     2         |             
      Mucosa, Hyperplasia                  |                               3                                          |             
      Mucosa, Metaplasia, Squamous         |          2     2                                               2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |          1                 1        3                             4      |             
      Cornea, Mineralization               |                                        1                                 |             
      Retina, Atrophy                      | 2        2  1        2  3  1  3  2  3  2  3           2  2        3      |             
      Sclera, Mineralization               |                         3        1                 1  2  2     2         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          X               |             
      Inflammation, Chronic                | 2  2  3  2  2  2  1     1        1  2              2  1        1     1   |             
      Inflammation, Suppurative            |             1  1                                                     1   |             
      Mineralization                       |          1           1           1        1                              |             
      Nephropathy                          | 2  2  3  2  3  2  2  1  2  2  2  1  2  1  2  2  1  1  1  1  2  2  1  1  1|             
      Capsule, Fibrosis                    |                                                                      2   |             
      Renal Tubule, Cytoplasmic Alteration |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 7| 0| 3| 3| 3| 0| 3| 3| 3| 3| 8| 9| 3| 3| 3| 2| 3| 3| 3| 3| 0| 9| 3| 3| 3|            |
                                           | 9| 0| 2| 2| 3| 7| 2| 3| 3| 3| 8| 3| 2| 3| 3| 6| 2| 3| 3| 3| 8| 6| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                               X                                          |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |             X                                                           X|      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                      X  X                                X           X   |      9     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |       X  X  X     X  X  X  X           X  X     X  X  X  X     X  X  X  X|     37     |
      Clear Cell Focus                     |          X                                X        X  X  X           X   |     15     |
      Developmental Malformation           |                                                                      X  X|      7     |
      Focal Cellular Change                |                                                                          |      4     |
      Granuloma                            |       1           1  2     1        1     1     1        1        2  2  4|     23  1.7|
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                1         |      2  1.5|
      Inflammation, Chronic Active         |          3                    2  1                                       |      3  2.0|
      Bile Duct, Cyst Multilocular         |                                                 X                        |      1     |
      Bile Duct, Hyperplasia               | 1  1  2     2  1  2  3  3  2  2  1  1  3     1  1  1  1  1  2  2     1  1|     47  1.9|
      Centrilobular, Atrophy               |                         2                                                |      2  2.5|
      Hepatocyte, Hyperplasia, Nodular     |                         2              2                                 |      3  2.3|
      Hepatocyte, Vacuolization Cytoplasmic|                      2        3           2     2     2     3            |     15  2.3|
      Lobules, Necrosis                    |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +        +        +           +  +           +  +           +  +     +|  16        |
      Artery, Hypertrophy                  |                                                                   3     2|      2  2.5|
      Artery, Inflammation, Chronic Active |                                                                   3     2|      3  2.7|
      Fat, Inflammation, Granulomatous     |                      3                             3                     |      3  3.0|
      Fat, Mineralization                  |             2        4           3              3              3         |      8  2.9|
      Fat, Necrosis                        |             4        4           4  1           4  4           3         |     12  3.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |             1  1                       1        2                       1|     10  1.2|
      Hyperplasia, Nodular                 |       2                                   3           3  2           2   |      6  2.2|
      Inflammation, Chronic                |             1                                                            |      4  1.0|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 7| 0| 3| 3| 3| 0| 3| 3| 3| 3| 8| 9| 3| 3| 3| 2| 3| 3| 3| 3| 0| 9| 3| 3| 3|            |
                                           | 9| 0| 2| 2| 3| 7| 2| 3| 3| 3| 8| 3| 2| 3| 3| 6| 2| 3| 3| 3| 8| 6| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                               3                                          |      1  3.0|
      Inflammation, Chronic                |                                                                      3   |      1  3.0|
      Perforation                          |                               X                                          |      1     |
      Mucosa, Dysplasia                    |                                                                      3   |      1  3.0|
      Mucosa, Hyperplasia                  |                               4                                      3   |      2  3.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                               4                                          |      1  4.0|
      Erosion                              |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Mineralization                       |                      2                                                   |      1  2.0|
      Ulcer                                |    3                                                                     |      2  2.5|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                  +                                       |   1        |
      Hyperkeratosis                       |                                  2                                       |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |       2  2  3     1  2  1  3  2  1        3  3  2  2     1  2  2  2  1   |     37  2.1|
      Thrombosis                           |                   X                                X                     |      2     |
      Epicardium, Inflammation, Chronic    |                                  3                                       |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                         X                                                |      4     |
      Angiectasis                          |                                                       2  2        3      |      5  2.4|
      Basophilic Focus                     |                                                          X               |      2     |
      Clear Cell Focus                     |    X                                         X  X              X  X      |      7     |
      Hyperplasia                          |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |             3                    2                                       |      3  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |                                           3                             3|      4  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 7| 0| 3| 3| 3| 0| 3| 3| 3| 3| 8| 9| 3| 3| 3| 2| 3| 3| 3| 3| 0| 9| 3| 3| 3|            |
                                           | 9| 0| 2| 2| 3| 7| 2| 3| 3| 3| 8| 3| 2| 3| 3| 6| 2| 3| 3| 3| 8| 6| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |                                                                   1     2|      4  1.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pigmentation                         |             1        1     1              1              1  2  1  1      |     18  1.2|
      C-Cell, Hyperplasia                  |                                                       1                  |      7  1.4|
      Follicle, Cyst                       |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                                          |      1  3.0|
      Inflammation, Chronic                |       2  2  3  2     3  3  2     2  2        2     2  2  3  2  3  2  3  2|     35  2.3|
      Inflammation, Suppurative            |             2           3                                            2   |      4  2.5|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Corpora Amylacea                     |       2                                                                  |      2  1.5|
      Ectasia                              |                                                                         3|      1  3.0|
      Fibrosis                             |                                                    1           2        3|      4  2.0|
      Inflammation, Chronic                |          1                    1     2           1                       2|     10  1.3|
      Inflammation, Suppurative            | 1     2  2  1  2              3     3        1  2  2           2         |     20  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |    2     3  2  1           2  3  1  2  2     2     2     1        1  3   |     24  2.0|
      Spermatocele                         |                               X                                          |      1     |
      Interstitial Cell, Hyperplasia       |                                                                          |      1  2.0|
      Seminiferous Tubule, Atrophy         |                               4                                          |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                         +                                                |   1        |
      Anemia                               |                         X                                                |      1     |
      Leukocytosis                         |                         X                                                |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  4.0|
      Hyperplasia, Reticulum Cell          |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Hyperplasia, Lymphoid      |                3                                                         |      1  3.0|
      Mediastinal, Erythrophagocytosis     |                                                    3                     |      2  3.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 7| 0| 3| 3| 3| 0| 3| 3| 3| 3| 8| 9| 3| 3| 3| 2| 3| 3| 3| 3| 0| 9| 3| 3| 3|            |
                                           | 9| 0| 2| 2| 3| 7| 2| 3| 3| 3| 8| 3| 2| 3| 3| 6| 2| 3| 3| 3| 8| 6| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
      Erythrophagocytosis                  |                                                                3         |      1  3.0|
      Hyperplasia, Plasma Cell             |                3              3                                   2      |      3  2.7|
      Lymphatic, Dilatation                |                3           3           3                                 |      5  3.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                    2                     |      1  2.0|
      Pigmentation                         | 3        1  1     1     1  1     2  2     2  2  1     3  2  3  1  2  1  1|     38  1.7|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                         2                                                |      2  2.5|
      Hematopoietic Cell Proliferation     |    3                                         2                       2   |      6  2.3|
      Hyperplasia, Re Cell                 |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                                                                          |      2     |
      Epithelial Cell, Hyperplasia         |             3                                                            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  47        |
      Hyperplasia, Cystic                  |             1        1  1  3  4     4     1     2              2         |     16  2.0|
      Hyperplasia, Lobular                 |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |          X                                                               |      1     |
      Fibrosis                             | 4              3                                                         |      2  3.5|
      Hemorrhage                           |                4                                                         |      1  4.0|
      Inflammation, Suppurative            | 4                                                                        |      1  4.0|
      Sebaceous Gland, Ectasia             |                      3                                                   |      1  3.0|
      Subcutaneous Tissue, Fibrosis        |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                  +                                       |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                               X                                          |      2     |
      Hydrocephalus                        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 7| 0| 3| 3| 3| 0| 3| 3| 3| 3| 8| 9| 3| 3| 3| 2| 3| 3| 3| 3| 0| 9| 3| 3| 3|            |
                                           | 9| 0| 2| 2| 3| 7| 2| 3| 3| 3| 8| 3| 2| 3| 3| 6| 2| 3| 3| 3| 8| 6| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Gray Matter, Degeneration            |                                                                         1|      1  1.0|
      Gray Matter, Necrosis                |       1                                                                  |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenomatosis                         |             3                                                            |      1  3.0|
      Congestion                           |                               3                                          |      1  3.0|
      Foreign Body                         |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |       1                       1        1              1  1        2  1  1|     18  1.1|
      Inflammation, Chronic                |       1                                                                  |      1  1.0|
      Mineralization                       |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                      2   |      2  2.0|
      Alveolus, Edema                      |                               2                                          |      1  2.0|
      Artery, Mediastinum, Hypertrophy     |             3                                                            |      1  3.0|
      Artery, Mediastinum, Inflammation,   |                                                                          |            |
           Chronic Active                  |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Exudate                              | X           X  X                       X     X  X        X     X  X      |     14     |
      Foreign Body                         |                                                                          |      1  2.0|
      Fungus                               | X              X                       X     X  X              X  X      |     10     |
      Inflammation, Chronic                |                2                       2     2                    3      |      7  2.4|
      Mucosa, Hyperplasia                  |                2                                2                        |      3  2.3|
      Mucosa, Metaplasia, Squamous         |                2                                                  3      |      5  2.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                             M            |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cataract                             |          3              2              2                       3  1      |      9  2.2|
      Cornea, Mineralization               |                                                                          |      1  1.0|
      Retina, Atrophy                      |       1  3  2  1  2  3  3  3     1  1  2  3  2     2           3  2  1   |     31  2.1|
      Sclera, Mineralization               |    2  2  3  2  2  2  2  2  2     1  2  2  1     2  1  1           3  2  1|     25  1.8|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1     |
      Inflammation, Chronic                |    2  2  2  2     2        2        2        3     2  1  3     2  2  2  2|     29  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 7| 0| 3| 3| 3| 0| 3| 3| 3| 3| 8| 9| 3| 3| 3| 2| 3| 3| 3| 3| 0| 9| 3| 3| 3|            |
                                           | 9| 0| 2| 2| 3| 7| 2| 3| 3| 3| 8| 3| 2| 3| 3| 6| 2| 3| 3| 3| 8| 6| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |       1  1        1                    1     1                 1         |      9  1.0|
      Mineralization                       |          1  1                       1                             1      |      8  1.0|
      Nephropathy                          | 1  2  2  2  2  1  3  1  2  2  3  1  2  2  2  2  1  2  2  2  1  3  2  2  2|     50  1.8|
      Capsule, Fibrosis                    |                                                                          |      1  2.0|
      Renal Tubule, Cytoplasmic Alteration |                                  3                                       |      1  3.0|
      Renal Tubule, Hyperplasia            |                            1                                             |      1  1.0|
      Transitional Epithelium, Hyperplasia |       1                                                                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 5| 7| 7| 7| 3| 5| 7| 7| 7| 4| 5| 6| 6| 6| 5| 5| 7| 7| 7| 4| 6| 7| 2| 7|             
                             DAY ON TEST   | 9| 5| 2| 2| 2| 8| 5| 2| 2| 2| 2| 0| 0| 8| 8| 7| 9| 1| 1| 2| 9| 2| 2| 0| 2|             
                                           | 9| 8| 9| 9| 9| 8| 8| 9| 9| 9| 7| 6| 5| 0| 0| 3| 3| 5| 8| 9| 9| 6| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    400.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  M  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                4         |             
      Inflammation, Suppurative            |                                                                3         |             
      Parasite Metazoan                    |                                              X                          X|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  M  +     +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                          2        1      |             
      Basophilic Focus                     |       X  X           X  X  X                       X  X  X        X     X|             
      Clear Cell Focus                     |       X     X                                                            |             
      Congestion                           |                                                    2                     |             
      Degeneration, Cystic                 |                                                                          |             
      Developmental Malformation           |          X  X  X  X                       X                              |             
      Focal Cellular Change                |                         X                                         X      |             
      Granuloma                            |                                                                          |             
      Hematopoietic Cell Proliferation     |                   1           2                 2                        |             
      Inflammation, Chronic                |                                                       1                  |             
      Inflammation, Chronic Active         |                                           1                              |             
      Bile Duct, Hyperplasia               |    2  2  2  2  2  1  2  3  2     2  2  3  1           2  2  3  3  2     1|             
      Centrilobular, Atrophy               |    2                          2                    2           2         |             
      Centrilobular, Necrosis              |                               2                                          |             
      Hepatocyte, Hyperplasia, Nodular     |    2                                                                    2|             
      Hepatocyte, Vacuolization Cytoplasmic|                4                                                         |             
      Kupffer Cell, Hyperplasia            |                                                                          |             
      Lobules, Necrosis                    |                         1                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +  +  +  +     +  +  +  +                    +     +        +      |             
      Accessory Spleen                     |                                                                          |             
      Artery, Hypertrophy                  |                                                                   2      |             
      Artery, Inflammation, Chronic Active |             2        2     2                                      3      |             
      Fat, Inflammation, Granulomatous     |                         4                                3               |             
      Fat, Mineralization                  |          3                 3  2                    3     3               |             
      Fat, Necrosis                        |       4  4     3        3  3  4                    4     3               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       3              4                             2                     |             
      Basophilic Focus                     |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 5| 7| 7| 7| 3| 5| 7| 7| 7| 4| 5| 6| 6| 6| 5| 5| 7| 7| 7| 4| 6| 7| 2| 7|             
                             DAY ON TEST   | 9| 5| 2| 2| 2| 8| 5| 2| 2| 2| 2| 0| 0| 8| 8| 7| 9| 1| 1| 2| 9| 2| 2| 0| 2|             
                                           | 9| 8| 9| 9| 9| 8| 8| 9| 9| 9| 7| 6| 5| 0| 0| 3| 3| 5| 8| 9| 9| 6| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    400.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Nodular                 |       2     3        3  2                       3        2               |             
      Inflammation, Chronic                |                      4                                                   |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                           3                              |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                          |             
      Mucosa, Hyperplasia                  |                                           3                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                          |             
      Mucosa, Dysplasia                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Fibrosis                      |                                                                          |             
      Aorta, Hemorrhage                    |                                                                          |             
      Aorta, Inflammation, Chronic         |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1     2  2  2     2  2  3     2     2  2     2  1  2  3  1  1  1  3     3|             
      Thrombosis                           |                                                                          |             
      Epicardium, Fibrosis                 |                                                                          |             
      Epicardium, Inflammation, Chronic    |                                                                          |             
      Myocardium, Inflammation, Chronic    |             3        2                                         3         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |       X                 X                       X                        |             
      Angiectasis                          |                                                                          |             
      Clear Cell Focus                     |                         X                       X                        |             
      Cyst                                 |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          |                                     1                                    |             
      Necrosis                             |                                                                      2   |             
      Vacuolization Cytoplasmic, Diffuse   |    3                                               3        3            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 5| 7| 7| 7| 3| 5| 7| 7| 7| 4| 5| 6| 6| 6| 5| 5| 7| 7| 7| 4| 6| 7| 2| 7|             
                             DAY ON TEST   | 9| 5| 2| 2| 2| 8| 5| 2| 2| 2| 2| 0| 0| 8| 8| 7| 9| 1| 1| 2| 9| 2| 2| 0| 2|             
                                           | 9| 8| 9| 9| 9| 8| 8| 9| 9| 9| 7| 6| 5| 0| 0| 3| 3| 5| 8| 9| 9| 6| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    400.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                X         |             
      Pars Distalis, Hyperplasia           |                                        1                       2  1      |             
      Pars Intermedia, Cyst                |                                                                          |             
      Pars Nervosa, Hyperplasia            |                                                             2            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |                      2                 1                 1     1  2      |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |    1              1                       1                              |             
      Follicle, Cyst                       |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                     +                                    |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                 4     2                 3|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |    2     2  3        2     2     2     3  2        2  2  3  2  2  2     2|             
      Inflammation, Suppurative            |             2                                                            |             
      Mineralization                       |          2                                                               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Corpora Amylacea                     |                                                                          |             
      Inflammation, Chronic                |                                                                   1     1|             
      Inflammation, Suppurative            |                         3        2                             1         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                            2              2  3                 2  2      |             
      Interstitial Cell, Hyperplasia       |                                  2                          2            |             
      Seminiferous Tubule, Atrophy         |                                              4     4     4               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
      Myelofibrosis                        |                                                                2         |             
      Proliferation                        |                   3                             3                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 5| 7| 7| 7| 3| 5| 7| 7| 7| 4| 5| 6| 6| 6| 5| 5| 7| 7| 7| 4| 6| 7| 2| 7|             
                             DAY ON TEST   | 9| 5| 2| 2| 2| 8| 5| 2| 2| 2| 2| 0| 0| 8| 8| 7| 9| 1| 1| 2| 9| 2| 2| 0| 2|             
                                           | 9| 8| 9| 9| 9| 8| 8| 9| 9| 9| 7| 6| 5| 0| 0| 3| 3| 5| 8| 9| 9| 6| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    400.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                                           3     3                        |             
      Lymphatic, Dilatation                |             3                    2              3                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                     2                                    |             
      Infiltration Cellular, Mast Cell     |                                                                          |             
      Pigmentation                         | 1  2  1  1  1        2  2  1        3        1  1        2  1  1         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                   3           4                 4                        |             
      Necrosis                             |    3                                                                     |             
      Pigmentation, Hemosiderin            | 3                                                                        |             
      Lymphoid Follicle, Atrophy           | 2                                                                        |             
      Red Pulp, Atrophy                    |                                                                      2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +|             
      Hyperplasia, Cystic                  |          2                                                              2|             
      Hyperplasia, Lobular                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |       X                                                                  |             
      Inflammation, Suppurative            |                         2                                                |             
      Mineralization                       |                         4  2                                             |             
      Ulcer                                |    3                                            4                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                            +                    +                        |             
      Hemorrhage                           |                                                 4                        |             
      Inflammation, Chronic                |                                                 4                        |             
      Mineralization                       |                            2                                             |             
      Necrosis                             |                                                 4                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                       X                  |             
      Corpora Amylacea                     |                                                                          |             
      Hemorrhage                           |                                                       3                  |             
      Inflammation, Chronic                |                                                                2         |             
      Necrosis                             |                                                                2         |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | M  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 5| 7| 7| 7| 3| 5| 7| 7| 7| 4| 5| 6| 6| 6| 5| 5| 7| 7| 7| 4| 6| 7| 2| 7|             
                             DAY ON TEST   | 9| 5| 2| 2| 2| 8| 5| 2| 2| 2| 2| 0| 0| 8| 8| 7| 9| 1| 1| 2| 9| 2| 2| 0| 2|             
                                           | 9| 8| 9| 9| 9| 8| 8| 9| 9| 9| 7| 6| 5| 0| 0| 3| 3| 5| 8| 9| 9| 6| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    400.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gray Matter, Degeneration            |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomatosis                         |                                                                          |             
      Congestion                           | 4              3                    3                                4   |             
      Infiltration Cellular, Histiocyte    |                   1     1                       4        1        1      |             
      Inflammation, Chronic                |             1                                                     2      |             
      Leukocytosis                         |                               2                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                       3                  |             
      Alveolus, Edema                      | 3                                                                    3   |             
      Artery, Mediastinum, Hypertrophy     |                                                                          |             
      Artery, Mediastinum, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                  X  X           X  X           X  X      |             
      Foreign Body                         |                                     2           2                        |             
      Fungus                               |                                                 X              X         |             
      Inflammation, Chronic                |                                                 2              2  2      |             
      Mucosa, Hyperplasia                  |                                                 2                 3      |             
      Mucosa, Metaplasia, Squamous         |                                                                2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |    +                                                                     |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  M  +  +  +  +  I  +  +  A  +  +  +  +  +  +  +  +  +|             
      Cataract                             |          2  2           2  1              1              1               |             
      Retina, Atrophy                      |    2  3  2  3     2     3  3     1     3  3     1  3  2  3  1  2  2     3|             
      Sclera, Mineralization               |             1              2     3     2           2  1  1  1  2        1|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                    2                     |             
      Infarct                              |             2     2                                            2         |             
      Inflammation, Chronic                |       4  2  4        2  2  3     2  2     3     2  3     3     2  4     4|             
      Inflammation, Suppurative            |       1     1                             1                       1      |             
      Mineralization                       |                                     1           1                        |             
      Nephropathy                          |    1  3  2  3  2  1  2  2  2  2  3  2  2  3  1  2  2  1  3  3  3  3     3|             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Necrosis               |                                                                3         |             
      Renal Tubule, Pigmentation           |                                                 2                        |             
      Transitional Epithelium, Hyperplasia |       2                                                                 3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 5| 7| 7| 7| 3| 5| 7| 7| 7| 4| 5| 6| 6| 6| 5| 5| 7| 7| 7| 4| 6| 7| 2| 7|             
                             DAY ON TEST   | 9| 5| 2| 2| 2| 8| 5| 2| 2| 2| 2| 0| 0| 8| 8| 7| 9| 1| 1| 2| 9| 2| 2| 0| 2|             
                                           | 9| 8| 9| 9| 9| 8| 8| 9| 9| 9| 7| 6| 5| 0| 0| 3| 3| 5| 8| 9| 9| 6| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    400.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 3| 3| 4| 5| 7| 1| 3| 7| 7| 7|            |
                             DAY ON TEST   | 6| 0| 2| 2| 2| 8| 9| 1| 2| 2| 1| 2| 2| 2| 2| 7| 7| 4| 5| 3| 5| 7| 1| 3| 3|            |
                                           | 4| 5| 9| 9| 9| 5| 7| 8| 9| 9| 2| 9| 9| 9| 9| 3| 5| 6| 8| 0| 4| 3| 2| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    400.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
      Edema                                |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Parasite Metazoan                    |                   X                                                      |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Inflammation, Granulomatous          |       1                                                                  |      1  1.0|
      Parasite Metazoan                    |                   X                                                  X  X|      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  45        |
      Parasite Metazoan                    |             X  X                                                     X   |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  M  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                            3                                         2   |      4  2.0|
      Basophilic Focus                     |       X     X        X  X        X  X  X                 X           X  X|     20     |
      Clear Cell Focus                     |                                     X     X              X               |      5     |
      Congestion                           |                                                                          |      1  2.0|
      Degeneration, Cystic                 |             2                                                            |      1  2.0|
      Developmental Malformation           |                      X                                                   |      6     |
      Focal Cellular Change                |                            X        X                                    |      4     |
      Granuloma                            |                                     1                                    |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      3  1.7|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               | 1           1     2  3  2  3     2  2  3  3  2  1  2  1  2        2  2  3|     37  2.1|
      Centrilobular, Atrophy               |                                                                          |      4  2.0|
      Centrilobular, Necrosis              |                               4                                   3      |      3  3.0|
      Hepatocyte, Hyperplasia, Nodular     |                      2     2                                            2|      5  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|       2                                                                  |      2  3.0|
      Kupffer Cell, Hyperplasia            |                                                                   2      |      1  2.0|
      Lobules, Necrosis                    |                                              3                           |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +           +              +  +        +  +  +           +   |  19        |
      Accessory Spleen                     |                                           X                              |      1     |
      Artery, Hypertrophy                  |             3                          3                                 |      3  2.7|
      Artery, Inflammation, Chronic Active |             3                          3                                 |      6  2.5|
      Fat, Inflammation, Granulomatous     |                                                          3               |      3  3.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 3| 3| 4| 5| 7| 1| 3| 7| 7| 7|            |
                             DAY ON TEST   | 6| 0| 2| 2| 2| 8| 9| 1| 2| 2| 1| 2| 2| 2| 2| 7| 7| 4| 5| 3| 5| 7| 1| 3| 3|            |
                                           | 4| 5| 9| 9| 9| 5| 7| 8| 9| 9| 2| 9| 9| 9| 9| 3| 5| 6| 8| 0| 4| 3| 2| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    400.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Fat, Mineralization                  |                         2                          3     2           3   |      9  2.7|
      Fat, Necrosis                        |                         2                          3     4           3   |     12  3.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Atrophy                              |       1                                                              2   |      5  2.4|
      Basophilic Focus                     |                                                                         X|      2     |
      Hyperplasia, Nodular                 |    3                       3           3                       2     3  3|     12  2.7|
      Inflammation, Chronic                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                           +                              |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                     2                                    |      1  2.0|
      Inflammation, Suppurative            |    4                                                                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      1  3.0|
      Inflammation, Chronic                |    3                                                                     |      1  3.0|
      Mineralization                       |                                                    1                     |      1  1.0|
      Ulcer                                |    4                                                                     |      1  4.0|
      Mucosa, Hyperplasia                  |    4                                               1                     |      3  2.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                               3                    3  3                  |      3  3.0|
      Hyperplasia, Lymphoid                |                                     3                                    |      1  3.0|
      Inflammation, Chronic Active         |       2                                                                  |      1  2.0|
      Mineralization                       |                      3                             3                 3   |      3  3.0|
      Ulcer                                |    3                                                           2         |      2  2.5|
      Mucosa, Dysplasia                    |                                     3                                    |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                       +                  |   1        |
      Aorta, Fibrosis                      |                                                       3                  |      1  3.0|
      Aorta, Hemorrhage                    |                                                       2                  |      1  2.0|
      Aorta, Inflammation, Chronic         |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    3  2  1  3  2  3  2  2     1  3  1  3  2  3  1  1  2  3        2  2  3|     40  2.1|
      Thrombosis                           |                                                                   X      |      1     |
      Epicardium, Fibrosis                 |                                                       2                  |      1  2.0|
      Epicardium, Inflammation, Chronic    |                                                       3                  |      1  3.0|
      Myocardium, Inflammation, Chronic    |                   1                                   2                  |      5  2.2|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 3| 3| 4| 5| 7| 1| 3| 7| 7| 7|            |
                             DAY ON TEST   | 6| 0| 2| 2| 2| 8| 9| 1| 2| 2| 1| 2| 2| 2| 2| 7| 7| 4| 5| 3| 5| 7| 1| 3| 3|            |
                                           | 4| 5| 9| 9| 9| 5| 7| 8| 9| 9| 2| 9| 9| 9| 9| 3| 5| 6| 8| 0| 4| 3| 2| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    400.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |          X  X                 X                       X              X   |      8     |
      Angiectasis                          |    4                                                                     |      1  4.0|
      Clear Cell Focus                     |                   X                    X              X           X     X|      7     |
      Cyst                                 |                                  X                                       |      1     |
      Fibrosis                             |    3                                                                     |      1  3.0|
      Hyperplasia                          |    2                                                                 2   |      3  1.7|
      Necrosis                             |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Diffuse   |    3                                                                     |      4  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|  49        |
      Hyperplasia                          |             1                          1  2                              |      3  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Cyst                  |                      X                                                   |      2     |
      Pars Distalis, Hyperplasia           |          1           2                             2  2              2   |      8  1.6|
      Pars Intermedia, Cyst                |                      X                                                   |      1     |
      Pars Nervosa, Hyperplasia            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pigmentation                         | 1                    1  1  2                                            1|     10  1.3|
      Ultimobranchial Cyst                 |                                                                         X|      1     |
      C-Cell, Hyperplasia                  |                                                       2                  |      4  1.3|
      Follicle, Cyst                       |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                      3     2                                             |      5  2.8|
      Hyperplasia                          |                         3                                                |      1  3.0|
      Inflammation, Chronic                |    2  2  3  2                    2     2              2  2     2     4   |     25  2.2|
      Inflammation, Suppurative            | 2                       4  3                          2           2      |      6  2.5|
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Corpora Amylacea                     |                                           2                              |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 3| 3| 4| 5| 7| 1| 3| 7| 7| 7|            |
                             DAY ON TEST   | 6| 0| 2| 2| 2| 8| 9| 1| 2| 2| 1| 2| 2| 2| 2| 7| 7| 4| 5| 3| 5| 7| 1| 3| 3|            |
                                           | 4| 5| 9| 9| 9| 5| 7| 8| 9| 9| 2| 9| 9| 9| 9| 3| 5| 6| 8| 0| 4| 3| 2| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    400.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |    3              2                                               1      |      5  1.6|
      Inflammation, Suppurative            |                   2                    2                          2      |      6  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +              +                                                      |   2        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |                      2     2     3  3  1                       1         |     11  2.1|
      Interstitial Cell, Hyperplasia       |                                                                          |      2  2.0|
      Seminiferous Tubule, Atrophy         |                               3     4        2        2                  |      7  3.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                  3                                       |      1  3.0|
      Hyperplasia, Reticulum Cell          |          2                                                               |      1  2.0|
      Myelofibrosis                        |                                                                          |      1  2.0|
      Proliferation                        |                   2                                                      |      3  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Hyperplasia, Plasma Cell|                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +     +  +  +  +|  46        |
      Hyperplasia, Plasma Cell             |                            2                                      3     2|      5  2.6|
      Lymphatic, Dilatation                |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  48        |
      Hemorrhage                           |                               2                       2                  |      3  2.0|
      Infiltration Cellular, Mast Cell     |                                                       3                  |      1  3.0|
      Pigmentation                         |       2  2        3     2     3  1  2  2        1  1  3                 2|     26  1.7|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                            3     3  1                                    |      3  2.3|
      Hematopoietic Cell Proliferation     |                   2           2  2                                       |      6  2.8|
      Necrosis                             |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            | 3                                                                        |      2  3.0|
      Lymphoid Follicle, Atrophy           | 2                                                                        |      2  2.0|
      Red Pulp, Atrophy                    | 2                                3  2                                    |      4  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  M|  44        |
      Hyperplasia, Cystic                  |       2  1        2  2                                            2      |      7  1.9|
      Hyperplasia, Lobular                 |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                       X                  |      2     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 3| 3| 4| 5| 7| 1| 3| 7| 7| 7|            |
                             DAY ON TEST   | 6| 0| 2| 2| 2| 8| 9| 1| 2| 2| 1| 2| 2| 2| 2| 7| 7| 4| 5| 3| 5| 7| 1| 3| 3|            |
                                           | 4| 5| 9| 9| 9| 5| 7| 8| 9| 9| 2| 9| 9| 9| 9| 3| 5| 6| 8| 0| 4| 3| 2| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    400.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                       3                  |      2  2.5|
      Mineralization                       |                                                                          |      2  3.0|
      Ulcer                                |                                                                          |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                            +                                             |   3        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      1     |
      Corpora Amylacea                     |                                                                         2|      1  2.0|
      Hemorrhage                           |                                                                         1|      2  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Gray Matter, Degeneration            |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenomatosis                         |          3                                                               |      1  3.0|
      Congestion                           | 3                                                  2        4  2         |      8  3.1|
      Infiltration Cellular, Histiocyte    |                                  1                    3  1           1   |      9  1.6|
      Inflammation, Chronic                |                                                                          |      2  1.5|
      Leukocytosis                         |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |       2                          1     2                                 |      4  2.0|
      Alveolus, Edema                      | 2                                                                        |      3  2.7|
      Artery, Mediastinum, Hypertrophy     |          2                                                               |      1  2.0|
      Artery, Mediastinum, Inflammation,   |                                                                          |            |
           Chronic Active                  |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Exudate                              |                            X                                         X   |      8     |
      Foreign Body                         |                            2                                             |      3  2.0|
      Fungus                               |                                                                          |      2     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 3| 3| 4| 5| 7| 1| 3| 7| 7| 7|            |
                             DAY ON TEST   | 6| 0| 2| 2| 2| 8| 9| 1| 2| 2| 1| 2| 2| 2| 2| 7| 7| 4| 5| 3| 5| 7| 1| 3| 3|            |
                                           | 4| 5| 9| 9| 9| 5| 7| 8| 9| 9| 2| 9| 9| 9| 9| 3| 5| 6| 8| 0| 4| 3| 2| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    400.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                            2                                             |      4  2.0|
      Mucosa, Hyperplasia                  |                                                                          |      2  2.5|
      Mucosa, Metaplasia, Squamous         |                            2                                             |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|  45        |
      Cataract                             |          2                 2        1     2                              |     10  1.6|
      Retina, Atrophy                      |       3  3  3  2  3  3  3  3     3  3  3  3           1  3        3  3  3|     35  2.6|
      Sclera, Mineralization               |       3     2     1     2        2  2     3              2           2  2|     20  1.9|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                   +      |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydronephrosis                       |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      3  2.0|
      Inflammation, Chronic                |    3  2  2  3  2  3  2  4  4     4  4  3  4              4        4  4  4|     32  3.1|
      Inflammation, Suppurative            |          1              1  1     1  1     1              1           1  1|     13  1.0|
      Mineralization                       |       1  1  1  1        2                          1  3              1   |     10  1.3|
      Nephropathy                          |    4  2  2  3  2  2  3  3  3  1  3  3  2  3     1     3  3     2  4  3  3|     44  2.4|
      Renal Tubule, Hyperplasia            |                   2                                                      |      1  2.0|
      Renal Tubule, Necrosis               |                               2                                          |      2  2.5|
      Renal Tubule, Pigmentation           |                      3                                2                  |      3  2.3|
      Transitional Epithelium, Hyperplasia |                   2     2                                2               |      5  2.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 9| 2| 2| 2| 6| 7| 1| 2| 2| 6| 5| 2| 2| 2| 3| 2| 2| 2| 2| 8| 1| 2| 2| 2|             
                                           | 8| 7| 9| 9| 9| 1| 6| 9| 8| 9| 4| 2| 9| 9| 9| 5| 9| 9| 9| 9| 2| 0| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                      2        2                                          |             
      Inflammation, Suppurative            |                               2                                          |             
      Parasite Metazoan                    |                            X                          X                 X|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                    X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                         2                                                |             
      Parasite Metazoan                    |                                     X           X                        |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       3                                            1                     |             
      Basophilic Focus                     |    X  X     X        X     X     X     X  X     X  X  X  X        X  X  X|             
      Clear Cell Focus                     |             X        X                 X              X  X              X|             
      Congestion                           |                                                                          |             
      Degeneration, Cystic                 |                                                 2  1                     |             
      Developmental Malformation           | X           X                                            X  X            |             
      Eosinophilic Focus                   |                                                                          |             
      Granuloma                            |                                  1  2     3              1        2  2  2|             
      Hematopoietic Cell Proliferation     |    2     2        2  3  3                                                |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                          2               |             
      Bile Duct, Cyst Multilocular         |                                                                   X      |             
      Bile Duct, Hyperplasia               | 1  2  3  2  2  2     2  2  3  2  3  2  2  3     3  2  2  3  1     2  1  2|             
      Centrilobular, Atrophy               |                                                                          |             
      Centrilobular, Necrosis              |    1              2     2                                                |             
      Hepatocyte, Hyperplasia, Nodular     |                2                                                         |             
      Hepatocyte, Vacuolization Cytoplasmic|       2           3  2           2           2              2     3  2   |             
      Kupffer Cell, Hyperplasia            | 2                             3                                          |             
      Kupffer Cell, Pigmentation           |                                                                3         |             
      Lobules, Necrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    M  +        +  +           +                 +  +     +        +     +|             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Artery, Mineralization               |                                                                          |             
      Fat, Inflammation, Granulomatous     |       2        2                                2  2                     |             
      Fat, Mineralization                  |       2        3              2                 3  2                     |             
      Fat, Necrosis                        |       4        4              4                 3  4                     |             
      Fat, Pigmentation                    |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 9| 2| 2| 2| 6| 7| 1| 2| 2| 6| 5| 2| 2| 2| 3| 2| 2| 2| 2| 8| 1| 2| 2| 2|             
                                           | 8| 7| 9| 9| 9| 1| 6| 9| 8| 9| 4| 2| 9| 9| 9| 5| 9| 9| 9| 9| 2| 0| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                   2                             3  2  1  1  1            |             
      Hyperplasia, Nodular                 |                                           3              2               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |          4                       2           2                           |             
      Inflammation, Chronic                |                                     2                                    |             
      Mineralization                       |                                                                          |             
      Ulcer                                |          4                                                               |             
      Mucosa, Hyperplasia                  |          3                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |          3                                                               |             
      Erosion                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       | 4                       3  3                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3  2  2  2  3     2  2  2  2  3  3  3  3           3  3  2  1  3     3  1|             
      Thrombosis                           |    X                    X     X                                          |             
      Myocardium, Inflammation, Chronic    | 3                                                                        |             
      Myocardium, Mineralization           | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                      X  X                 X                              |             
      Angiectasis                          |             2                                         2     2        2   |             
      Clear Cell Focus                     |          X                                X                 X            |             
      Hematopoietic Cell Proliferation     |    2              3  3  2                                                |             
      Hyperplasia                          | 4                    2                                   2        2      |             
      Vacuolization Cytoplasmic, Diffuse   | 3                                                                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2  1                                                   |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |       2                                                                  |             
      Pars Distalis, Cyst                  |                                                    X              X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 9| 2| 2| 2| 6| 7| 1| 2| 2| 6| 5| 2| 2| 2| 3| 2| 2| 2| 2| 8| 1| 2| 2| 2|             
                                           | 8| 7| 9| 9| 9| 1| 6| 9| 8| 9| 4| 2| 9| 9| 9| 5| 9| 9| 9| 9| 2| 0| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Hyperplasia           |    2  2     1     3              3     1                    3            |             
      Pars Intermedia, Angiectasis         |                                                          3               |             
      Pars Intermedia, Cyst                |                                                    X                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Concretion                           |                                                                      2   |             
      Mineralization                       | 2                                                                        |             
      Pigmentation                         |       1     1     1              1  1  2  1        1  1  1        1      |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |       3                       2  1     2              2  1           2  2|             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                          3               |             
      Pigmentation                         |                                                          2               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |    4                                   2                                 |             
      Hyperplasia                          |    3                                                                     |             
      Inflammation, Chronic                |          2        2  2  2  2        2  2  2        3  3           2      |             
      Inflammation, Suppurative            |                      2                 2              2           2      |             
      Metaplasia, Squamous                 |    4                    2                                                |             
      Necrosis                             |    3                                                                     |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Corpora Amylacea                     |                         2                                                |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic                |    2     2              2  1                    1     1  1              2|             
      Inflammation, Suppurative            |    2     3     2           3  2                 2     1     1  2        2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 2     1           3        3  3        2  3     2  2  2  3  2  1     1   |             
      Seminiferous Tubule, Atrophy         | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Depletion Cellular                   |                                                                          |             
      Proliferation                        | 2  3              3     3     3              2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 9| 2| 2| 2| 6| 7| 1| 2| 2| 6| 5| 2| 2| 2| 3| 2| 2| 2| 2| 8| 1| 2| 2| 2|             
                                           | 8| 7| 9| 9| 9| 1| 6| 9| 8| 9| 4| 2| 9| 9| 9| 5| 9| 9| 9| 9| 2| 0| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Erythrophagocytosis     |                                                                   3      |             
      Mediastinal, Hemorrhage              |                               3                                          |             
      Mediastinal, Hyperplasia, Reticulum  |                                                                          |             
          Cell                             |                               3                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Mast Cell                       |                               3                                          |             
      Mediastinal, Pigmentation            |                3  3                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |                                                                          |             
      Erythrophagocytosis                  |                   2                                                      |             
      Hemorrhage                           |                               2                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                      3                                                   |             
      Hyperplasia, Reticulum Cell          |                               3                                          |             
      Lymphatic, Dilatation                | 3                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |                                                                          |             
      Erythrophagocytosis                  |                                                             2            |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Mast Cell     |                3                                                         |             
      Pigmentation                         | 1     2     2  1  1  3  2  1     3     3  2     1     2  1  3     3  2  2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                             1            |             
      Fibrosis                             |                                                                         3|             
      Hematopoietic Cell Proliferation     | 2  3              4  3  4  2  3     2        3                           |             
      Hyperplasia, Re Cell                 |                                                                          |             
      Pigmentation, Hemosiderin            | 2        3     3                                            3            |             
      Lymphoid Follicle, Atrophy           | 3                                                                        |             
      Red Pulp, Atrophy                    |                                                                      2  3|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  M  M  M  +  M  M  +  M  +  M  M  M  +  M  +  M  +  M  +  +  M  M|             
      Epithelial Cell, Hyperplasia         |                                                    2     2               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia, Cystic                  |          4           2  2  3        1                          3         |             
      Hyperplasia, Lobular                 |                            2                                             |             
      Inflammation, Granulomatous          |                                                                   2      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Cyst Epithelial Inclusion            |                                     X              X                     |             
      Cyst Multilocular                    |                                                                          |             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 9| 2| 2| 2| 6| 7| 1| 2| 2| 6| 5| 2| 2| 2| 3| 2| 2| 2| 2| 8| 1| 2| 2| 2|             
                                           | 8| 7| 9| 9| 9| 1| 6| 9| 8| 9| 4| 2| 9| 9| 9| 5| 9| 9| 9| 9| 2| 0| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Hair Follicle, Atrophy               |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
      Subcutaneous Tissue, Granuloma       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hyperostosis                | 3                                                                        |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                   +  +                          +                        |             
      Edema                                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |          X     2                                                         |             
      Developmental Malformation           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                2                                                         |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mast Cell     |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Axon, Hypertrophy                    |    3                                                                     |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gray Matter, Cytoplasmic Alteration  |                                        2                                 |             
      Gray Matter, Degeneration            |       1                                                                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomatosis                         |       2                                                                  |             
      Congestion                           |                         2                                                |             
      Foreign Body                         |          2                                                               |             
      Infiltration Cellular, Histiocyte    |          2                 1              1           1  1  1        2   |             
      Inflammation, Chronic                |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                           1           2                  |             
      Alveolus, Edema                      |                                                                          |             
      Lymphatic, Dilatation                |                                                    3                     |             
      Mediastinum, Edema                   |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              | X                                                     X              X  X|             
      Foreign Body                         |                                                                          |             
      Fungus                               | X                                                                    X   |             
      Inflammation, Chronic                |                                                                      3   |             
      Mucosa, Hyperplasia                  |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 9| 2| 2| 2| 6| 7| 1| 2| 2| 6| 5| 2| 2| 2| 3| 2| 2| 2| 2| 8| 1| 2| 2| 2|             
                                           | 8| 7| 9| 9| 9| 1| 6| 9| 8| 9| 4| 2| 9| 9| 9| 5| 9| 9| 9| 9| 2| 0| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    200.                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mucosa, Metaplasia, Squamous         | 2                                                                    2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2                                                                        |             
      Mineralization                       | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |    3                                                                     |             
      Hemorrhage                           | 3                                                                        |             
      Cornea, Inflammation, Chronic        | 2                                                                        |             
      Retina, Atrophy                      |    2  3  1  1        1     1        1     3        2        2        3  2|             
      Sclera, Mineralization               |          2           2  3  1        1  2        1  2     3     1     2  2|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                  3                                       |             
      Fibrosis                             |                         2                                                |             
      Glomerulosclerosis                   |                         2                                                |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Chronic                |       2  2  2              1     2  3  3  3           2  2        3  2  2|             
      Inflammation, Suppurative            |                                     1           1  1  1           1  1   |             
      Mineralization                       | 4                 1     2     2     1                       1            |             
      Nephropathy                          | 3  1  2  3  2  2  1  2  1  2  2  3  3  2  3     3  3  2  2  2  1  3  3  2|             
      Renal Tubule, Degeneration           |                                                                          |             
      Renal Tubule, Pigmentation           |                2  3                                                      |             
      Venule, Infiltration Cellular,       |                                                                          |             
          Histiocyte                       |                                                             2            |             
      Venule, Pigmentation                 |                                                             2            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 1| 2| 2| 2| 9| 2| 2| 2| 2| 1| 0| 2| 3| 3| 1| 3| 1| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 8| 4| 9| 9| 9| 5| 9| 9| 9| 9| 7| 8| 2| 0| 0| 4| 2| 1| 0| 0| 2| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    200.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Edema                                |                                                                          |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Parasite Metazoan                    |                            X                                             |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                               X                       X                  |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |                                                                          |      1  2.0|
      Parasite Metazoan                    |             X     X     X                                      X        X|      7     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |    2              2                                                      |      4  2.0|
      Basophilic Focus                     |       X  X  X        X     X        X  X     X     X  X  X  X  X  X  X  X|     31     |
      Clear Cell Focus                     |          X                                X              X  X           X|     11     |
      Congestion                           |                                  3                 3                     |      2  3.0|
      Degeneration, Cystic                 |                                                                          |      2  1.5|
      Developmental Malformation           |                                     X                    X               |      6     |
      Eosinophilic Focus                   |             X                                                            |      1     |
      Granuloma                            |          1                 1              1                          1  2|     12  1.6|
      Hematopoietic Cell Proliferation     |                3                                                         |      6  2.5|
      Hemorrhage                           | 3                                                                        |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Bile Duct, Cyst Multilocular         |                                                                          |      1     |
      Bile Duct, Hyperplasia               | 2     3  2  2  2  2  3  4  2  1     3  1  2  1  3  2  2  2  1  2  2  2  3|     45  2.1|
      Centrilobular, Atrophy               |                                     2                                    |      1  2.0|
      Centrilobular, Necrosis              |                1                                                         |      4  1.5|
      Hepatocyte, Hyperplasia, Nodular     |                         3                       2                        |      3  2.3|
      Hepatocyte, Vacuolization Cytoplasmic|    3              2                       2     2        2              3|     14  2.3|
      Kupffer Cell, Hyperplasia            | 2                                            2                           |      4  2.3|
      Kupffer Cell, Pigmentation           |    3                                                                     |      2  3.0|
      Lobules, Necrosis                    | 2  2                             3                                       |      3  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +  +        +  +     +     +  +     +     +        +        +  +     +|  22        |
      Artery, Inflammation, Chronic Active |                   2                                                      |      1  2.0|
      Artery, Mineralization               |                                              3                           |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 1| 2| 2| 2| 9| 2| 2| 2| 2| 1| 0| 2| 3| 3| 1| 3| 1| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 8| 4| 9| 9| 9| 5| 9| 9| 9| 9| 7| 8| 2| 0| 0| 4| 2| 1| 0| 0| 2| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    200.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Fat, Inflammation, Granulomatous     |       2                       3        3              4        3        2|     10  2.5|
      Fat, Mineralization                  |    3           2        3        3     2              3        2        3|     13  2.5|
      Fat, Necrosis                        |    4  3        4        4     4  4     3              4        4        4|     15  3.8|
      Fat, Pigmentation                    |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                1                                                     1  2|      9  1.6|
      Hyperplasia, Nodular                 |                      2     2                                   3        3|      6  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          2                             2                                 |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      3  2.7|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Mineralization                       |                                           4  3                           |      2  3.5|
      Ulcer                                |                                  4        4                              |      3  4.0|
      Mucosa, Hyperplasia                  |                                  3        4                              |      3  3.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  3.0|
      Erosion                              |    2                                               2                     |      2  2.0|
      Inflammation, Chronic                |                               3                                      3   |      2  3.0|
      Mineralization                       |                                           3  4                 3         |      6  3.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                              +                           |   1        |
      Aorta, Mineralization                |                                              4                           |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 3  3  2     3  2  2  2  2  2  2  3     2  2  2  3     3  1  3  1  2  3  2|     42  2.3|
      Thrombosis                           | X                                                                        |      4     |
      Myocardium, Inflammation, Chronic    |                                                                         1|      2  2.0|
      Myocardium, Mineralization           |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                     X  X  X     X           X     X     X|     10     |
      Angiectasis                          |                   2                                3                     |      6  2.2|
      Clear Cell Focus                     |             X              X              X                              |      6     |
      Hematopoietic Cell Proliferation     |                                                                          |      4  2.5|
      Hyperplasia                          |    4  2                    1        2                    2               |      9  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 1| 2| 2| 2| 9| 2| 2| 2| 2| 1| 0| 2| 3| 3| 1| 3| 1| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 8| 4| 9| 9| 9| 5| 9| 9| 9| 9| 7| 8| 2| 0| 0| 4| 2| 1| 0| 0| 2| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    200.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Vacuolization Cytoplasmic, Diffuse   |    4                                3        2  3           3            |      6  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2           2     2        1                                             |      6  1.7|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  | X                    X     X                                X            |      6     |
      Pars Distalis, Hyperplasia           | 3                       1                                2               |     10  2.1|
      Pars Intermedia, Angiectasis         |                                                                          |      1  3.0|
      Pars Intermedia, Cyst                |                         X                                                |      2     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Concretion                           |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Pigmentation                         | 2        1        1        1        1           1        1              1|     19  1.1|
      Ultimobranchial Cyst                 |                                                                         X|      1     |
      C-Cell, Hyperplasia                  |                         2  3           3        1  1     2              2|     15  1.9|
      Follicle, Cyst                       |                               X                                X         |      2     |
      Follicular Cell, Hyperplasia         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              | +                                                                        |   1        |
      Hemorrhage                           | 2                                                                        |      1  2.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                   3                 2                                    |      4  2.8|
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Chronic                |       2     2        2     2  2     2  2  3        2  2  2  2        2  2|     25  2.1|
      Inflammation, Suppurative            |          4           2     1                          1              2   |      9  2.0|
      Metaplasia, Squamous                 |                                                                          |      2  3.0|
      Necrosis                             |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 1| 2| 2| 2| 9| 2| 2| 2| 2| 1| 0| 2| 3| 3| 1| 3| 1| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 8| 4| 9| 9| 9| 5| 9| 9| 9| 9| 7| 8| 2| 0| 0| 4| 2| 1| 0| 0| 2| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    200.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Corpora Amylacea                     |    2     2                    2        2        2                        |      6  2.0|
      Fibrosis                             |          3              2              2              2                  |      4  2.3|
      Inflammation, Chronic                | 2        2        2     2        3  1  1        1  1  2        1     3  1|     21  1.6|
      Inflammation, Suppurative            | 2  2     3  2  1  2  2     2  2  3  2  3           3  2  1     2        1|     27  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +                                         +                           |   2        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                      3     1     1  1     1                 2     3  2  1|     23  2.0|
      Seminiferous Tubule, Atrophy         | 1  4  4                             3  2     4                           |      7  3.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                   3      |      1  3.0|
      Depletion Cellular                   |    3                                                                     |      1  3.0|
      Proliferation                        |                2                             3                 3         |      9  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Erythrophagocytosis     |                                                                          |      1  3.0|
      Mediastinal, Hemorrhage              |                                                             4            |      2  3.5|
      Mediastinal, Hyperplasia, Reticulum  |                                                                          |            |
          Cell                             |                                                                          |      1  3.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Mast Cell                       |                                                                          |      1  3.0|
      Mediastinal, Pigmentation            |                                                                   3      |      3  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +|  48        |
      Depletion Cellular                   | 3                                                                        |      1  3.0|
      Erythrophagocytosis                  |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                    3                     |      1  3.0|
      Hyperplasia, Plasma Cell             |                                                    2                     |      2  2.5|
      Hyperplasia, Reticulum Cell          |                                                                          |      1  3.0|
      Lymphatic, Dilatation                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Depletion Cellular                   | 3                                                                        |      1  3.0|
      Erythrophagocytosis                  | 3                                                                        |      2  2.5|
      Hemorrhage                           |                                                             4            |      1  4.0|
      Infiltration Cellular, Mast Cell     |                               3                                          |      2  3.0|
      Pigmentation                         | 1           2     2     2  2  1     1        1  2     2  2  3  2  2     2|     33  1.9|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 1| 2| 2| 2| 9| 2| 2| 2| 2| 1| 0| 2| 3| 3| 1| 3| 1| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 8| 4| 9| 9| 9| 5| 9| 9| 9| 9| 7| 8| 2| 0| 0| 4| 2| 1| 0| 0| 2| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    200.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis                             |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                4                       2                                 |     11  2.9|
      Hyperplasia, Re Cell                 |                                           4                              |      1  4.0|
      Pigmentation, Hemosiderin            |    3                                                                     |      5  2.8|
      Lymphoid Follicle, Atrophy           | 2                                                                        |      2  2.5|
      Red Pulp, Atrophy                    | 2                                                                        |      3  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +|  30        |
      Epithelial Cell, Hyperplasia         |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Cystic                  |    2     4           1  2        2  3  2     4                 2     1   |     16  2.4|
      Hyperplasia, Lobular                 |       2        1                 3     2                                 |      5  2.0|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  49        |
      Acanthosis                           |                                                    2                     |      1  2.0|
      Cyst Epithelial Inclusion            |             X     X              X  X                                    |      6     |
      Cyst Multilocular                    |             X                                                            |      1     |
      Foreign Body                         |             3                                                            |      1  3.0|
      Inflammation, Chronic                |                                                    2                     |      1  2.0|
      Inflammation, Granulomatous          |             4                                                            |      1  4.0|
      Inflammation, Suppurative            |                                                 4                        |      1  4.0|
      Hair Follicle, Atrophy               |                                                    3                     |      1  3.0|
      Subcutaneous Tissue, Edema           | 3                                                                        |      1  3.0|
      Subcutaneous Tissue, Granuloma       |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Hyperostosis                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +                                                                        |   4        |
      Edema                                | 3                                                                        |      1  3.0|
      Inflammation, Chronic Active         | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      2  2.0|
      Developmental Malformation           |                            X                                             |      1     |
      Hemorrhage                           |                               4                 1                        |      2  2.5|
      Hydrocephalus                        |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 1| 2| 2| 2| 9| 2| 2| 2| 2| 1| 0| 2| 3| 3| 1| 3| 1| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 8| 4| 9| 9| 9| 5| 9| 9| 9| 9| 7| 8| 2| 0| 0| 4| 2| 1| 0| 0| 2| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    200.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Mast Cell     |                                                    3                     |      1  3.0|
      Inflammation, Chronic                |                                                                   3      |      1  3.0|
      Axon, Hypertrophy                    |                                                    1                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Gray Matter, Cytoplasmic Alteration  |                                                                          |      1  2.0|
      Gray Matter, Degeneration            |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenomatosis                         |                                                                          |      1  2.0|
      Congestion                           |    3                                               3        3            |      4  2.8|
      Foreign Body                         |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |    4     1     1  1           2                 2                    1   |     14  1.5|
      Inflammation, Chronic                |          1                                                               |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                               2                                          |      3  1.7|
      Alveolus, Edema                      |    4                                                                     |      1  4.0|
      Lymphatic, Dilatation                |                                                                          |      1  3.0|
      Mediastinum, Edema                   | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Exudate                              |          X  X                       X        X           X               |      9     |
      Foreign Body                         |             2                                3           2               |      3  2.3|
      Fungus                               |             X                                X                           |      4     |
      Inflammation, Chronic                |             3                                            3               |      3  3.0|
      Mucosa, Hyperplasia                  |                                              3                           |      2  3.0|
      Mucosa, Metaplasia, Squamous         |             2                       3        2                           |      5  2.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |             2                                                            |      2  2.0|
      Mineralization                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cataract                             |                         1           1                                    |      3  1.7|
      Hemorrhage                           |                                                                          |      1  3.0|
      Cornea, Inflammation, Chronic        |                                                                          |      1  2.0|
      Retina, Atrophy                      | 2     1  2  1     3  1  1  2        3     3  2  2        1     1  1  2   |     28  1.8|
      Sclera, Mineralization               |    2  1  3           2     1        2     2     1  1     1     2  3  2  1|     26  1.8|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05006-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            BENZALDEHYDE                                       Date: 04/30/97  
Route: GAVAGE                                                                                                     Time: 09:26:06  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 1| 2| 2| 2| 9| 2| 2| 2| 2| 1| 0| 2| 3| 3| 1| 3| 1| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 8| 4| 9| 9| 9| 5| 9| 9| 9| 9| 7| 8| 2| 0| 0| 4| 2| 1| 0| 0| 2| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    200.                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Glomerulosclerosis                   |                                                                          |      1  2.0|
      Hydronephrosis                       |                                              4                           |      1  4.0|
      Inflammation, Chronic                |          2  2     3  3     3  2  2  2  2  3  2        3  3     1  2  3  2|     30  2.3|
      Inflammation, Suppurative            |                   2  1     1              1           1  1           2   |     13  1.2|
      Mineralization                       | 3     1                    1           1     3        1  1     1     1   |     15  1.6|
      Nephropathy                          | 2  4  3  3  3  1  3  3  1  3  2  2  3  3  3  4  2  2  3  3  3  1  2  3  2|     49  2.4|
      Renal Tubule, Degeneration           |                         4                                                |      1  4.0|
      Renal Tubule, Pigmentation           |                                                                          |      2  2.5|
      Venule, Infiltration Cellular,       |                                                                          |            |
          Histiocyte                       |                                                                          |      1  2.0|
      Venule, Pigmentation                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.