National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3144

TDMS Study 05007-05 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                           POLYSORBATE 80


NTP Experiment-Test: 05007-05                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/03/94
Route: DOSED FEED                                                                                                 Time: 11:32:42




       Facility:  Southern Research Institute

       Chemical CAS #:  9005-65-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05007-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 11:32:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     2.5%         5.0%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                  9           10           10                                                  
  Early Deaths                                                                                                                      
    Dead                                              13           15           15                                                  
    Moribund                                           8            7            9                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           28           26                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (22)         (49)                                                
   Gallbladder                                        (46)         (18)         (47)                                                
   Intestine Large, Rectum                            (48)         (17)         (47)                                                
      Leiomyoma                                                                  1 (2%)                                             
   Intestine Small, Ileum                             (47)         (18)         (45)                                                
   Intestine Small, Jejunum                           (48)         (19)         (47)                                                
      Fibrosarcoma, Metastatic, Mesentery                                        1 (2%)                                             
   Liver                                              (50)         (25)         (49)                                                
      Hepatocellular Carcinoma                         1 (2%)       1 (4%)                                                          
      Hepatocellular Adenoma                           2 (4%)       1 (4%)       2 (4%)                                             
   Mesentery                                          (10)         (5)          (13)                                                
      Fibrosarcoma                                                               1 (8%)                                             
      Fibrosarcoma, Metastatic, Skin                   1 (10%)                                                                      
   Pancreas                                           (47)         (22)         (48)                                                
      Fibrosarcoma, Metastatic, Mesentery                                        1 (2%)                                             
   Salivary Glands                                    (46)         (18)         (46)                                                
   Stomach, Forestomach                               (49)         (50)         (49)                                                
      Glandular, Fibrosarcoma, Metastatic,                                                                                          
          Mesentery                                                              1 (2%)                                             
   Stomach, Glandular                                 (49)         (49)         (48)                                                
   Tooth                                                                        (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (22)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05007-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 11:32:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     2.5%         5.0%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (22)         (50)                                                
   Adrenal Gland, Medulla                             (50)         (22)         (50)                                                
      Pheochromocytoma NOS                                                       2 (4%)                                             
   Islets, Pancreatic                                 (47)         (21)         (48)                                                
   Pituitary Gland                                    (46)         (20)         (48)                                                
      Pars Distalis, Adenoma                          11 (24%)      2 (10%)     15 (31%)                                            
   Thyroid Gland                                      (49)         (19)         (46)                                                
      Follicle, Adenoma                                1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (48)         (36)         (50)                                                
      Adenoma                                          1 (2%)                                                                       
      Granulosa Cell Tumor Benign                                   1 (3%)                                                          
      Luteoma                                                                    1 (2%)                                             
   Uterus                                             (50)         (42)         (50)                                                
      Leiomyoma                                                                  1 (2%)                                             
      Endometrium, Polyp Stromal                       3 (6%)                                                                       
      Endometrium, Sarcoma Stromal                     1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (22)         (50)                                                
      Hemangiosarcoma, Metastatic, Spleen                                        1 (2%)                                             
   Lymph Node                                         (49)         (26)         (49)                                                
   Lymph Node, Mandibular                             (46)         (16)         (46)                                                
   Lymph Node, Mesenteric                             (48)         (23)         (48)                                                
   Spleen                                             (49)         (25)         (49)                                                
      Hemangiosarcoma                                               1 (4%)       1 (2%)                                             
   Thymus                                             (48)         (20)         (48)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (19)         (48)                                                
      Adenocarcinoma                                                             1 (2%)                                             
   Skin                                               (50)         (38)         (50)                                                
      Sebaceous Gland, Carcinoma                                                 1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                4 (8%)                    2 (4%)                                             
                                                             Page   3                                                               
NTP Experiment-Test: 05007-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 11:32:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     2.5%         5.0%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Hemangioma                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (22)         (50)                                                
      Sternum, Osteosarcoma                            1 (2%)                                                                       
   Skeletal Muscle                                                              (2)                                                 
      Hemangiosarcoma, Metastatic, Spleen                                        1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (22)         (50)                                                
   Spinal Cord                                        (1)                       (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (22)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     3 (6%)       1 (5%)       2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma                                1 (5%)       1 (2%)                                             
   Nose                                               (49)         (22)         (50)                                                
   Trachea                                            (49)         (21)         (47)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)          (1)                                                 
   Harderian Gland                                                              (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (23)         (50)                                                
   Urinary Bladder                                    (49)         (18)         (48)                                                
      Hemangioma                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant Lymphocytic                   5 (10%)      3 (6%)       3 (6%)                                             
      Lymphoma Malignant Mixed                        12 (24%)      6 (12%)      8 (16%)                                            
      Lymphoma Malignant Undifferentiated Cell         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   4                                                               
NTP Experiment-Test: 05007-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 11:32:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     2.5%         5.0%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            30          16          29                                                   
     Total Primary Neoplasms                           47          18          44                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 17           5          19                                                   
     Total Benign Neoplasms                            22           5          24                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          11          17                                                   
     Total Malignant Neoplasms                         25          13          18                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1                       2                                                   
     Total Metastatic Neoplasm                          1                       5                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                          2                                                   
     Total Uncertain Neoplasms                                                  2                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   5                                                               
NTP Experiment-Test: 05007-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 11:32:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     2.5%         5.0%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                  7            7           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                           9           11            9                                                  
    Dead                                               9            8            9                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           34           32                                                  
    Dead                                               1                                                                            
  Missing                                              1                                                                            
  Other                                                1                                                                            
  Animals Examined Microscopically                    49           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (47)         (16)         (50)                                                
   Intestine Small, Duodenum                          (46)         (16)         (49)                                                
   Intestine Small, Ileum                             (46)         (15)         (48)                                                
   Intestine Small, Jejunum                           (46)         (16)         (49)                                                
   Liver                                              (49)         (23)         (50)                                                
      Hemangiosarcoma                                               1 (4%)                                                          
      Hepatocellular Carcinoma                        11 (22%)      7 (30%)      5 (10%)                                            
      Hepatocellular Adenoma                           5 (10%)      7 (30%)      6 (12%)                                            
      Neoplasm NOS                                     1 (2%)                                                                       
   Mesentery                                          (1)          (5)          (3)                                                 
      Squamous Cell Carcinoma, Metastatic, Stomach                  1 (20%)                                                         
   Pancreas                                           (48)         (17)         (50)                                                
   Salivary Glands                                    (49)         (16)         (49)                                                
   Stomach, Forestomach                               (48)         (50)         (50)                                                
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Squamous Cell Papilloma                          1 (2%)                                                                       
   Stomach, Glandular                                 (48)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (16)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   6                                                               
NTP Experiment-Test: 05007-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 11:32:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     2.5%         5.0%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (16)         (50)                                                
      Adenoma                                                                    2 (4%)                                             
   Adrenal Gland, Medulla                             (49)         (16)         (50)                                                
      Pheochromocytoma NOS                             1 (2%)       1 (6%)       2 (4%)                                             
   Islets, Pancreatic                                 (48)         (17)         (50)                                                
   Pituitary Gland                                    (47)         (15)         (49)                                                
      Pars Intermedia, Adenoma                                      1 (7%)                                                          
   Thyroid Gland                                      (49)         (16)         (49)                                                
      Follicle, Adenoma                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (16)         (50)                                                
   Preputial Gland                                    (13)         (14)         (11)                                                
      Squamous Cell Carcinoma                                       2 (14%)                                                         
   Prostate                                           (49)         (17)         (50)                                                
   Seminal Vesicle                                    (49)         (16)         (49)                                                
   Testes                                             (49)         (17)         (50)                                                
      Interstitial Cell, Adenoma                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (17)         (50)                                                
   Lymph Node                                         (49)         (28)         (50)                                                
   Lymph Node, Mandibular                             (49)         (14)         (49)                                                
   Lymph Node, Mesenteric                             (48)         (28)         (46)                                                
   Spleen                                             (48)         (21)         (49)                                                
      Hemangioma                                                                 1 (2%)                                             
   Thymus                                             (47)         (16)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (49)         (42)         (50)                                                
      Squamous Cell Carcinoma                          1 (2%)       1 (2%)                                                          
      Squamous Cell Papilloma                                       1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     5 (10%)      5 (12%)      3 (6%)                                             
      Subcutaneous Tissue, Fibrosarcoma                4 (8%)       5 (12%)      5 (10%)                                            
      Subcutaneous Tissue, Fibrous Histiocytoma        1 (2%)       3 (7%)       2 (4%)                                             
                                                             Page   7                                                               
NTP Experiment-Test: 05007-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 11:32:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     2.5%         5.0%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Hemangioma                               1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Neurofibrosarcoma           1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                                  1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (1)          (2)                                                 
      Sarcoma                                                                    1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (16)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (21)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     5 (10%)      5 (24%)      5 (10%)                                            
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (5%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)       2 (10%)      2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (3)          (1)                                                 
      Adenoma                                                       3 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (16)         (50)                                                
   Urinary Bladder                                    (47)         (16)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(49)        *(50)        *(50)                                                
      Leukemia Granulocytic                                                      1 (2%)                                             
      Lymphoma Malignant Histiocytic                                             1 (2%)                                             
      Lymphoma Malignant Lymphocytic                                2 (4%)                                                          
      Lymphoma Malignant Mixed                         3 (6%)       2 (4%)       5 (10%)                                            
      Mesothelioma Malignant                                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   8                                                               
NTP Experiment-Test: 05007-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 11:32:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     2.5%         5.0%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            32          34          31                                                   
     Total Primary Neoplasms                           41          51          44                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 15          20          15                                                   
     Total Benign Neoplasms                            17          23          20                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          23          17                                                   
     Total Malignant Neoplasms                         22          27          22                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           3           2                                                   
     Total Metastatic Neoplasm                          1           3           2                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  2           1           2                                                   
     Total Uncertain Neoplasms                          2           1           2                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   9                                                               
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